SAKURAI Toshiharu 桜井敏晴

Researcher Number	20101933
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2007 – 2014: Keio University, School of Medicine, Instructor 2009: 医学部, 助教 1998 – 2006: 慶應義塾大学, 医学部, 助手 2000: School of Medicine, Keio University Instructor, 医学部, 助手
Review Section/Research Field	Principal Investigator Dermatology / Dermatology / Digestive surgery / Experimental pathology Except Principal Investigator Digestive surgery / Biological Sciences / Dermatology / Tumor immunology / Digestive surgery
Keywords	Principal Investigator TIL / 免疫抑制 / Snail / HLA-A2.6 / HLA-A2.1V / HLA tetramer / HLA-A24 / HLA-A2 / HLAテトラマー / 悪性黒色腫 … More / immunosuppression / gastroenterogic cancer / epithelial-mesenchymal transition / 免疫応答 / コルポスコピー / 細胞診 / 子宮頸癌 / ラマン分光 / 消化器癌 / 上皮-間葉転換 / novel antoantogens / cDNA expression cloning analysis / Human IgG antibody / SCID mice / salivary and lacrimal glands biopsy tissue / Sjogren's syndrome (SS) / 新規自己抗原 / cDNA発現クローニング / ヒトIgG抗体 / SCIDマウス / 病巣涙腺・唾液腺 / シェーグレン症候群(SS) / CMV-antigen peptide / melanoma-antigen peptide / HLA-A2.1 / CTL / HLA-A^2402 / HLA-A^0201 / CMV抗原ペプチド / HLA-A2.6V / メラノーマ抗原ペプチド / Tumor infiltration lymphocyte (TIL) / Human Leukocyte Antigen (HLA) / Desmoglein 3 (Dsg 3) / T lymphocyte / Pemphigus vulgaris (PV) / HLA / デスモグレイン3 / T細胞 / 尋常性天疱瘡 / 細胞分子機構 / 免疫病態 / TGF-β / がん免疫療法 / TGF-b1 / 免疫抑制機構 / センチネルリンパ節 / シグナル伝達 / 樹状細胞 / シグナル伝達異常 / 免疫療法 / 皮膚腫瘍学 … More Except Principal Investigator 免疫療法 / 腫瘍抗原 / 樹状細胞 / 大腸癌 / 免疫抑制 / SAGE / DNAチップ / T細胞 / Immunotherapy / Microsatellite instability / CDX2 / マイクロサテライト不安定性 / 癌精巣抗原 / 膵癌 / 免疫回避 / RNA干渉 / 悪性黒色腫 / 上皮間葉転換 / 色素細胞 / SEREX / DNAクローニング / 網羅的遺伝子解析 / Immune escape / Tumor markers / DNA chip / Pancreas cancer / Colon cancer / Tumor antigens / RDA / K-ras / SCID / MSI / 潰瘍性大腸炎 / p53 / 免疫不全マウス / 癌幹細胞 / 腫瘍マーカー / 膵臓癌 / T lymphocyte / Antibody / Frameshift / Tumor antigen / Colorectal cancer / 遺伝子診断 / 腫瘍特異的変異ペプチド / SEREX法 / cDNAクローニング / フレイムシフト / 抗体 / フレームシフト / DNA cloning / EST databases / cDNA profile / melanocyte / melanoma / メラノソーム蛋白 / mRNAプロファイル / SAGE法 / EST / cDNAプロファイル / ESTデータベース / 生体内腫瘍破壊法 / エフェクター細胞 / 免疫抑制制御 / 免疫チェックポイント阻害 / がん免疫療法 / 癌遺伝子 / 消化器癌 / シグナル伝達阻害 / HLA遺伝子導入マウス / 転移 / 制御性T細胞 / 免疫抵抗性 / がん幹細胞 / ペプチド / 慢性骨髄性白血病 / 癌抗原 / レンチウイルス / siRNA / メラノーマ Less

Elucidation of the condition of construction mechanisms of immunity on sentinel lymph nodes of patients with melanoma and development of novel immunotherapyPrincipal Investigator
- Principal Investigator
  
  SAKURAI TOSHIHARU
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
Development of effective immunotherapy by combining interventions on key points in the anti-tumor immune network
- Principal Investigator
  
  KAWAKAMI Yutaka
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Tumor immunology
- Research Institution
  Keio University
Elucidation of the resistance mechanisms of immunotherapy by the abnormal signal transduction in melanoma and development of methods to overcome itPrincipal Investigator
- Principal Investigator
  
  SAKURAI Toshiharu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
Development of effective immunotherapy by combining methods to restore immunocompetence of cancer patients
- Principal Investigator
  
  KAWAKAMI Yutaka
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Keio University
The study of immunosuppressive mechanisms induced by gastrointestinal cancer during epithelial-mesnchymal transition and clinical application of this target therapyPrincipal Investigator
- Principal Investigator
  
  SAKURAI Toshiharu
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Keio University
Development of immunotherapy based on the identification of tumor antigens
- Principal Investigator
  
  KAWAKAMI Yutaka
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
Identification of novel autoantigens using human IgG in SCID mice implanted with lacrimal and salivary grands from patients with Sjogren's SyndromePrincipal Investigator
- Principal Investigator
  
  SAKURAI Toshiharu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Keio University
Development of new diagnostic and immunotherapeutic methods for patients with cancer
- Principal Investigator
  
  KAWAKAMI Yutaka
- Project Period (FY)
  2002 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Digestive surgery
- Research Institution
  KEIO UNIVERSITY
Using soluble HLA-peptide tetramer, the studies on the cloning and immune-response monitoring of melanoma antigen-specific cytotoxic lymphocytePrincipal Investigator
- Principal Investigator
  
  SAKURAI Toshiharu
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
メラノーマに対する新しい免疫療法の開発
- Principal Investigator
  
  KAWAKAMI Yutaka
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
Systematic isolation of genes encoding candidate proteins for human melanoma antigens using serial analysis of gene expression (SAGE) and EST database
- Principal Investigator
  
  KAWAKAMI Yutaka
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
Development of diagnositic and therapeutic methods using frameshift mutated peptides for colorectal cancers with microsatellite instability
- Principal Investigator
  
  KAWAKAMI Yutaka
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Keio University
Using solubel peptide-MHC tetramer, the trial of staining and cloning the melanoma antigen-specific cytotoxic lymphocytesPrincipal Investigator
- Principal Investigator
  
  SAKURAI Toshiharu, 池田英之
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
Development and Characterization of Desmoglein-3 Specific T cells from Japanese Patients with Pemphigus VulgarisPrincipal Investigator
- Principal Investigator
  
  SAKURAI Toshiharu
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Keio University

All 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004

All Journal Article Presentation Book

[Book] Gene Therapy(Development of individualized immunotherapy based on the analysis on anti-tumor immune responses to the human tumor antigens identified using immunological and genetic methods)2009
- Author(s)
  Kawakami Y, Fujita T, Kudo C, Sakurai T, Udagawa M, Hasegawa G, Ishida A, Kitagawa Y, Tanabe M, Saito M, Izumi Y, Kawamura M, Yaguchi T, Ueda Y, Hayashi E, Wang Q, Tsukamoto N, Matsuzaki Y, Sumimoto H,Takeuchi H, Tanikawa A, Handa M, Amagai M, Kobayashi K, Ikeda Y, Azuma I, Kitajima M
- Data Source
  KAKENHI-PROJECT-17016070
[Journal Article] TGF-β1 in tumor microenvironments induces immunosuppression in the tumors and sentinel lymph nodes and promotes tumor progression2014
- Author(s)
  Nakamura S, Yaguchi T, Kawamura N, Kobayashi A, Sakurai T, Higuchi H, Takaishi H, Hibi T, Kawakami Y
- Journal Title
  
  J Immunother
  
  Volume: 37(2) Issue: 2 Pages: 63-72
- DOI
  10.1097/cji.0000000000000011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23240128, KAKENHI-PROJECT-24249046, KAKENHI-PROJECT-24591635, KAKENHI-PROJECT-25830122
[Journal Article] Biomarkers for cancer immunotherapy2012
- Author(s)
  Kawakami Y, Kawase Y, Ohizumi A, Noji S, Sakurai T, Fujita T.
- Journal Title
  
  Nihon Rinsho.
  
  Volume: 70 Pages: 759-66
- NAID
  40019297634
- Data Source
  KAKENHI-PROJECT-24591635
[Journal Article] Immune suppression and resistance mediated by constitutive activation of Wnt/β-catenin signaling in human melanoma cells2012
- Author(s)
  Yaguchi T.
- Journal Title
  
  J Immunol.
  
  Volume: 189 Issue: 5 Pages: 2110-2117
- DOI
  10.4049/jimmunol.1102282
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501025, KAKENHI-PROJECT-23240128, KAKENHI-PROJECT-23659554, KAKENHI-PROJECT-23791293, KAKENHI-PROJECT-24501358, KAKENHI-PROJECT-24591635, KAKENHI-PROJECT-24592532
[Journal Article] 【がん免疫学と免疫療法の新展開】がん免疫病態と免疫動態の評価2012
- Author(s)
  河上裕, 谷口智憲, 中村公子, 川瀬芳恵, 野路しのぶ, 大泉梓, 南雲春菜, 長谷川舞, 徐明利, 岡本正人, 桜井敏晴, 藤田知信
- Journal Title
  
  血液フロンティア
  
  Volume: 22 Pages: 1183-1190
- Data Source
  KAKENHI-PROJECT-24591635
[Journal Article] 癌微小環境におけるPD-L1/PD-1による免疫抑制病態とその是正2011
- Author(s)
  川村直、谷口智憲、桜井敏晴、河上裕
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: Vol.56, No.1 Pages: 1-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591445
[Journal Article] 癌微小環境におけるPD-L1/PD-1による免疫抑制病態とその是正2011
- Author(s)
  川村直、谷口智憲、桜井敏晴、河上裕
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 56 Pages: 1-6
- Data Source
  KAKENHI-PROJECT-23240128
[Journal Article] 腫瘍免疫制御機構とその克服2009
- Author(s)
  河上裕、住本秀敏、工藤千恵、塚本信夫、桜井敏晴、植田良、谷口智憲、川村直、梶原知子
- Journal Title
  
  最新医学
  
  Volume: Vol.64、No.11
- Data Source
  KAKENHI-PROJECT-21591445
[Journal Article] Dendritic cell based personalized immunotherapy based on cancer antigen research2008
- Author(s)
  Kawakami Y, Fujita T, Kudo C, Sakurai T, Udagawa M, Yaguchi T, Hasegawa G, Hayashi E, Ueda Y, Iwata T, Wang Q, Okada S, Tsukamoto N, Matsuzaki Y, Sumimoto H.
- Journal Title
  
  Frontier in Bioscience 13
  
  Pages: 1952-1958
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390355
[Journal Article] Development of individualized immunotherapy based on the analysis on anti-tumor immune responses to the human tumor antigens identified using immunological and genetic methods.2007
- Author(s)
  Kawakami Y, Fujita T, Kudo C, Sakurai T, Udagawa M, Hasegawa G, Ishida A, Kitagawa Y, Tanabe M, Saito M, Izumi Y, Kawamura M, Yaguchi T, Ueda Y, Hayashi E, Wang Q, Tsukamoto N, Matsuzaki Y, Sumimoto H, Takeuchi H, Tanikawa A, H, a M, Amagai M, Kobayashi K, Ikeda Y, Azuma I, Kitajima M.
- Journal Title
  
  Gene Therapy
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104013
[Journal Article] Development of individualized immunotherapy based on the analysis on anti-tumor immune responses to the human tumor antigens identified using immunological and genetic methods2007
- Author(s)
  Kawakami Y, Fujita T, Kudo C, Sakurai T, Udagawa M, Hasegawa G, Ishida A, Kitagawa Y, Tanabe M, Saito M, Izumi Y, Kawamura M, Yaguchi T, Ueda Y, Hayashi E, Wang Q, Tsukamoto N, Matsuzaki Y, Sumimoto H, Takeuchi H, Tanikawa A, Handa M, Amagai M, Kobayashi K, Ikeda Y, Azuma I, and Kitajima M.
- Journal Title
  
  Gene Therapy
  
  Pages: 240-248
- Data Source
  KAKENHI-PROJECT-19390355
[Journal Article] Frequent immune response to a melanocyte specific protein KU-MEL-1 in patients with Vogt-Koyanagi-Harada disease.2006
- Author(s)
  Otani S, Sakurai T, Kawakami Y
- Journal Title
  
  British Journal of Ophthalmology volume 90, number 6
  
  Pages: 773-777
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590324
[Journal Article] Frequent immune response to a melanocyte specific protein KU-MEl-1 in patients with Vogt-Koyanagi-Harada disease.2006
- Author(s)
  Otani S, Sakurai T, Kawakami Y
- Journal Title
  
  British Journal of Ophthalmology 90巻、6号
  
  Pages: 773-777
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590324
[Journal Article] Systematic identification of human melanoma antigens using serial analysis of gene expression (SAGE).2005
- Author(s)
  Matsuzaki Y, Hashimoto S, Fujita T, Suzuki T, Sakurai T, Matsushima K, Kawakami Y
- Journal Title
  
  J Immunother 28(1)
  
  Pages: 10-19
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016070
[Journal Article] Systematic identification of human melanoma antigens using serial analysis of gene expression(SAGE)2005
- Author(s)
  Matsuzaki Y, Hashimoto S, Fujita T, Suzuki T, Sakurai T, Matsushima K, Kawakami Y.
- Journal Title
  
  J. Immunother. 28
  
  Pages: 10-19
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104013
[Journal Article] Identification of human tumor antigens and its implication for diagnosis and treatment of cancer.2004
- Author(s)
  Kawakami Y, Fujita T, Matsuzaki Y, Sakurai T, Tsukamoto M, Toda M, Sumimoto H.
- Journal Title
  
  Cancer Sci. 95
  
  Pages: 784-791
- NAID
  10014170333
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104013
[Presentation] 腫瘍浸潤T細胞は大腸癌の予後マーカーとなる2014
- Author(s)
  藤田知信、徐明利、ポピバノバボリヤナ、岡本正人、桜井敏晴、鳥越俊彦、古畑智久、杉浦史哲、奥野清隆、硲彰一、岡正朗、河上裕
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜(横浜）
- Year and Date
  2014-09-27
- Data Source
  KAKENHI-PROJECT-24591635
[Presentation] Cancer-induced differential immune-status among patients and it'smodification for effective cancer treatment2014
- Author(s)
  Kawakami Y, Popivanova B, Nagumo H, Muramatsu R, Shinobu Noji, Xu M, Fujita T, Okamoto M, Sakurai T, Sugiyama J, Hayakawa T, Satomi R, Nishio H, Yaguchi T
- Organizer
  Cold Spring Harbor Asia, Frontiers of Immunology in Health and Diseases
- Place of Presentation
  Suzhou, China　(中国）
- Year and Date
  2014-09-04
- Invited
- Data Source
  KAKENHI-PROJECT-24591635
[Presentation] 局所性Renin-Angiotensin systemの阻害による、がん関連線維芽細胞や骨髄系免疫細胞の制御を介したPD-1/PD-L1免疫チェックポイント阻害療法の効果増強2014
- Author(s)
  中村謙太、谷口智憲、大村学、小林明日香、川村直、杉山重里、桜井敏晴、木庭幸子、奥山隆平、河上裕
- Organizer
  第18回日本がん免疫学会総会
- Place of Presentation
  ひめぎんホール (愛媛)
- Year and Date
  2014-08-01
- Data Source
  KAKENHI-PROJECT-24591635
[Presentation] 局所性Renin-Angiotensin systemの阻害による、がん関連線維芽細胞や骨髄系免疫細胞の制御を介したPD-1/PD-L1免疫チェックポイント阻害療法の効果増強2014
- Author(s)
  中村謙太、谷口智憲、大村学、小林明日香、川村直、杉山重里、桜井敏晴、木庭幸子、奥山隆平、河上裕
- Organizer
  第42回日本臨床免疫学会
- Place of Presentation
  京王プラザホテル（東京）
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-24591635
[Presentation] The high plasma IL6 and IL8 are biomarkers for predicting poor clinical outcome of cancer patients treated with peptide cancer vaccines2013
- Author(s)
  Fujita Tomonobu, Noji Shinobu, Nagumo Haruna, Okamoto Masato, Sakurai Toshiharu, Noguchi Masanori, Matsueda Satoko, Itoh Kyogo, Hazama Shoichi, Oka Masaaki, Kawakami Yutaka
- Organizer
  第42回日本免疫学会総会
- Place of Presentation
  幕張メッセ　（千葉）
- Data Source
  KAKENHI-PROJECT-24591635
[Presentation] Strong correlation of tumor-infiltrating CD8+ and Foxp3+ T cells with favorable prognosis of patients with colon cancer2013
- Author(s)
  Xu Mingli, Noji Shinobu, Okamoto Masato, Sakurai Toshiharu, Fujita Tomonobu, Torigoe Toshihiko, Sato Noriyuki, Sugiura Fumiaki, Okuno Kiyotaka, Hazama Shoichi, Oka Masaaki, Kawakami Yutaka
- Organizer
  第42回日本免疫学会総会
- Place of Presentation
  幕張メッセ　（千葉）
- Data Source
  KAKENHI-PROJECT-24591635
[Presentation] Different immunoenvironments among cancer patients-Possible Biomarkers and modification for effective cancer treatments2013
- Author(s)
  Kawakami Y, Xu M, Nagumo H, Fujita T, Okamoto M, Sakurai T, Noji S, Sugiyama J, Hayakawa T, Nishio H, Yaguchi T
- Organizer
  Cold Spring Harbor Conferences Asia, Tumor Immunolgy & Immunotherapy
- Place of Presentation
  Suzhou Dushu Lake Conference Center Suzhou, China
- Year and Date
  2013-10-29
- Data Source
  KAKENHI-PROJECT-23240128
[Presentation] 切除不能進行膵癌に対するgemcitabine併用WT1ペプチドパルス樹状細胞ワクチン療法第I相試験2013
- Author(s)
  真柳修平、北郷実、竹内裕也、松田達雄、樋口肇、浜本康夫、高石官均、田口淳一、砂村真琴、藤田知信、桜井敏晴、河上裕、北川雄光
- Organizer
  第11回日本臨床腫瘍学会学術集会
- Place of Presentation
  仙台国際センター、東北大学百周年記念会館川内萩ホール、宮城県
- Data Source
  KAKENHI-PROJECT-23240128
[Presentation] Tumor immunology Different tumor immunoenvironments among patients: Biomarkers and their modification for cancer treatments2013
- Author(s)
  Kawakami Yutaka, Xu Mingli, Nagumo Haruna, Fujita Tomonobu, Okamoto Masato, Sakurai Toshiharu, Noji Shinobu, Sugiyama Juri, Hayakawa Taeko, Nishio Hiroshi, Yaguchi Tomonori
- Organizer
  第42回日本免疫学会総会
- Place of Presentation
  幕張メッセ　（千葉）
- Data Source
  KAKENHI-PROJECT-24591635
[Presentation] 局所性Renin-Angiotensin systemは免疫抑制的がん微小環境の構築に関与する2013
- Author(s)
  中村謙太、谷口智憲、大村学、小林明日香、川村直、杉山重里、桜井敏晴、木庭幸子、奥山隆平、河上裕
- Organizer
  第17回日本がん免疫学会
- Place of Presentation
  ANAクラウンプラザホテル宇部、山口県
- Data Source
  KAKENHI-PROJECT-23240128
[Presentation] ヒトがん免疫病態の解明と免疫バイオマーカーの同定2013
- Author(s)
  河上裕、徐明利、谷口智憲、野路しのぶ、南雲春菜、岡本正人、桜井敏晴、藤田知信、鳥越俊彦、佐藤昇志、中面哲也、垣見和宏、池田裕明、珠玖洋、奥野清隆、杉浦史哲、中山睿一、硲彰一、岡正朗、伊東恭悟
- Organizer
  第17回日本がん免疫学会
- Place of Presentation
  ANAクラウンプラザホテル宇部、山口県
- Data Source
  KAKENHI-PROJECT-23240128
[Presentation] ifferent tumor immunoenvironments among patients: Biomarkers and their modification for cancer treatment.2013
- Author(s)
  Kawakami Yutaka, Xu Mingli, Nagumo Haruna, Fujita Tomonobu , Okamoto Masato, Sakurai Toshiharu, Noji Shinobu, Sugiyama Juri, Hakawa Taeko, Nishio Hiroshi, Yaguchi Tomonori,
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ、千葉県
- Data Source
  KAKENHI-PROJECT-23240128
[Presentation] Different immunoenvironments among cancer patients-Possible Biomarkers and modification for effective cancer treatments.2013
- Author(s)
  Yutaka Kawaami, Mingli Xu, haruna Nagumo, Tomonobu Fujita, Masato Okamoto, Toshiharu Sakurai, Shinobu Noji, Juri Sugiyama, Taeko Hayakawa, Hiroshi Nishio, Tomonori Yaguchi,
- Organizer
  2013Cold Spring Harbor Conferences Asia, Tumor Immunolgy & Immunotherapy,
- Place of Presentation
  Suzhou Dushu Lake Conference Center　蘇州、中国
- Invited
- Data Source
  KAKENHI-PROJECT-23240128
[Presentation] Immunosuppresive roles of local renin angiotensin system (RAS) in cancer microenvironments.2013
- Author(s)
  Nakamura Kenta, Tomonori Yaguchi, Gaku Ohmura, Asuka Kobayasi, Naosi Kawamura, Juri Sugiyama, Toshiharu Sakurai, Yukiko Kiniwa, Ryuhei Okuyama, Yutaka Kawakami
- Organizer
  第72回日本癌学会総会
- Place of Presentation
  パシフィコ横浜　（横浜）
- Data Source
  KAKENHI-PROJECT-24591635
[Presentation] 癌微小環境におけるレニン・アンジオテンシンシステムの免疫抑制性の役割2013
- Author(s)
  中村謙太、谷口智憲、大村学、小林明日香、川村直、杉山重里、桜井敏晴、木庭幸子、奥山隆平、河上裕
- Organizer
  第72回日本癌学会
- Place of Presentation
  パシフィコ横浜、神奈川県
- Data Source
  KAKENHI-PROJECT-23240128
[Presentation] 能動免疫療法における免疫誘導・抗腫瘍効果を規定するバイオマーカーの検索2012
- Author(s)
  川瀬芳恵、藤田知信、大泉梓、野路しのぶ、桜井敏晴、南雲春菜、徐明利、中山睿一、垣見和宏、鳥越俊彦、池田裕明、珠玖洋、岡本正人、河上裕
- Organizer
  第16回日本がん免疫学会
- Place of Presentation
  北海道大学学術交流会館
- Data Source
  KAKENHI-PROJECT-24591635
[Presentation] Poor responses to dendritic cell immunotherapy in patients with high serum cytokines related to chronic inflammation2011
- Author(s)
  Kawase Y, Sakurai T, Fujita T, Kawakami Y, その他
- Organizer
  第70回日本癌学会総会
- Place of Presentation
  名古屋国際会議場、名古屋
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-21591445
[Presentation] Role of IL6/IL8-NF-KB AXIS in the Immunosuppression and resistance to immunotherapy2011
- Author(s)
  Kawakami Y, Nishio H, Yaguchi T, Kawase Y, Ohizumi A, Noji S, Sakurai T, Umezawa K, Fujita T
- Organizer
  26th Annual Meeting Society for Immunotherapy of Cancer
- Place of Presentation
  North Bethesda, MD, USA
- Year and Date
  2011-11-04
- Data Source
  KAKENHI-PROJECT-23240128
[Presentation] Poor responses to dendritic cell immunotherapy in patients with high serum cytokines related to chronic inflammation2011
- Author(s)
  Kawase Y、Sakurai T、Kawakami Y, その他
- Organizer
  第70回日本癌学会
- Place of Presentation
  愛知県・名古屋国際会議場
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-21591445
[Presentation] 悪性黒色腫および樹状細胞でのWnt/β-cateninシグナル亢進はがん微小環境での免疫抑制に関与する2010
- Author(s)
  谷口智憲、桜井敏晴、塚本信夫、藤田知信、河上裕
- Organizer
  第14回日本がん免疫学会総会
- Place of Presentation
  KKRホテル熊本、熊本
- Year and Date
  2010-07-23
- Data Source
  KAKENHI-PROJECT-21591445
[Presentation] Possible improvement of cancer immunotherapy based on the analyses of anti-tumor immune responses in human2010
- Author(s)
  Yutaka Kawakami, Nobuo Tsukamoto, Tomonobu Fujita, Toshiharu Sakurai, Tomonori Yaguchi
- Organizer
  金沢国際がん生物学シンポジュウム
- Place of Presentation
  KKRホテル金沢、金沢
- Year and Date
  2010-08-29
- Data Source
  KAKENHI-PROJECT-21591445
[Presentation] 消化器癌に対する樹状細胞を腫瘍内投与による免疫療法の第I相臨床試験2008
- Author(s)
  藤田知信、田邉稔、北川雄光、石田明、桜井敏晴、半田誠、北島政樹、河上裕
- Organizer
  第38回日本免疫学会
- Place of Presentation
  京都
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-19390355
[Presentation] 培養樹状細胞を用いた免疫療法2008
- Author(s)
  河上裕, 住本秀敏, 工藤千恵, 塚本信夫, 藤田知信, 桜井敏晴, 谷口智憲, 岩田知子, 川村直
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-19390355
[Presentation] 癌細胞におけるMAPKシグナル亢進による腫瘍免疫逃避機構の解明2008
- Author(s)
  谷口智憲、木藤健治、塚本信夫、桜井敏晴、藤田知信、持丸博史、丸山正太郎、里見良輔、井田陽介、住本秀敏、河上裕
- Organizer
  第38回日本免疫学会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-17016070
[Presentation] 癌細胞におけるMAPKシグナル亢進による腫瘍免疫逃避機構の解明2008
- Author(s)
  谷口智憲、木藤健治、塚本信夫、桜井敏晴、藤田知信、持丸博史、丸山正太郎、里見良輔、井田陽介、住本秀敏、河上裕
- Organizer
  第38回日本免疫学会
- Place of Presentation
  京都
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-19390355
[Presentation] Phase I/II clinical trial of immunotherapy by intratumoral administration of dendritic cells for patients with melanoma2008
- Author(s)
  Saito M, Fujita T, Tanikawa A, Ishida A, Sakurai T, Handa M, Amagai M, Kawakami Y
- Organizer
  20th International Pigment Cell Conference & 5th International Melanoma Research Congress
- Place of Presentation
  Royton Sapporo(Japan)
- Year and Date
  2008-05-10
- Data Source
  KAKENHI-PROJECT-17016070
[Presentation] Wnt/β-cateninシグナル亢進による悪性黒色腫の免疫逃避機構の解明2008
- Author(s)
  谷口智憲、木藤健治、塚本信夫、桜井敏晴、持丸博史、丸山正太郎、里見良輔、井田陽介、住本秀敏、河上裕
- Organizer
  第12回基盤的癌免疫研究会総会
- Place of Presentation
  大宮ソニックシティ
- Year and Date
  2008-07-03
- Data Source
  KAKENHI-PROJECT-17016070
[Presentation] Wnt/beta-cateninシグナル亢進による悪性黒色種の免疫逃避機構の解明2008
- Author(s)
  谷口智憲、木藤健治、塚本信夫、桜井敏晴、持丸博史、丸山正太郎、里見良輔、井田陽介、住本秀敏、河上裕
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-17016070
[Presentation] 培養樹状細胞を用いた免疫療法2008
- Author(s)
  河上裕、住本秀敏、工藤千恵、塚本信夫、藤田知信、桜井敏晴、谷口智憲、岩田知子、川村直
- Organizer
  第67回日本癌学会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-19390355
[Presentation] 癌細胞におけるMAPKシグナル亢進による腫瘍免疫逃避機構の解明2008
- Author(s)
  谷口智憲, 木藤健治, 塚本信夫, 桜井敏晴, 藤田知信, 持丸博史, 丸山正太郎, 里見良輔, 井田陽介, 住本秀敏, 河上裕
- Organizer
  第38回日本免疫学会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-19390355
[Presentation] 消化器癌に対する樹状細胞を腫瘍内投与による免疫療法の第1相臨床試験2008
- Author(s)
  藤田知信, 田邉稔, 北川雄光, 石田明, 桜井敏晴, 半田誠, 北島政樹, 河上裕
- Organizer
  第38回日本免疫学会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-19390355
[Presentation] 培養樹状細胞を用いた免疫療法2008
- Author(s)
  河上裕、住本秀敏、工藤千恵、塚本信夫、藤田知信、桜井敏晴、谷口智憲、岩田知子、川村直
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-17016070
[Presentation] 悪性黒色腫に対するBCG-CWS感作樹状細胞の腫瘍内投与による臨床試験2008
- Author(s)
  藤田知信、斉藤昌孝、石田明、桜井敏晴、谷川瑛子、半田誠、天谷雅行、河上裕
- Organizer
  第12回基盤的癌免疫研究会総会
- Place of Presentation
  大宮ソニックシティ
- Year and Date
  2008-07-03
- Data Source
  KAKENHI-PROJECT-17016070
[Presentation] Immunotherapy by intratumoral administration of dendritic cells2007
- Author(s)
  Kawakami Y, Fujita T, Kudo C, Udagawa M, Sakurai T, Ueda Y, Yaguchi T, Sumimoto H
- Organizer
  第66回日本癌学会
- Place of Presentation
  横浜
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-19390355
[Presentation] Development of invidualized immunotherapy by intratumoral injection of dendritc cells based on the immunological analysis of the malanoma antigens identified by various methods2005
- Author(s)
  Kawakami Y, Fujita T, Matsuzaki Y, Sakurai T, Tsukamoto M, Sumimoto H, Hasegawa G, Udagawa M
- Organizer
  19th International Pigment cell Conference
- Place of Presentation
  Reston VA, USA
- Year and Date
  2005-09-21
- Data Source
  KAKENHI-PROJECT-17016070

1. KAWAKAMI Yutaka (50161287)

# of Collaborated Projects: 14 results

# of Collaborated Products: 50 results
2. FUJITA Tomonobu (20199334)

# of Collaborated Projects: 10 results

# of Collaborated Products: 28 results
3. MATSUZAKI Yuriko (40255435)

# of Collaborated Projects: 7 results

# of Collaborated Products: 6 results
4. KUDO Chie (90424126)

# of Collaborated Projects: 5 results

# of Collaborated Products: 8 results
5. TSUKAMOTO Nobuo (20407117)

# of Collaborated Projects: 5 results

# of Collaborated Products: 15 results
6. SUMIMOTO Hidetoshi (00306838)

# of Collaborated Projects: 4 results

# of Collaborated Products: 15 results
7. TSUKAMOTO Makoto (50365441)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
8. YAGUCHI Tomonori (40424163)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
9. UEDA Ryo (30317143)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. KITAGAWA Yuukou (20204878)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. KAWAMURA Naoshi (30570246)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. OHTA Shigeki (20365406)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. NAKAMURA Shoko (20528228)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
14. NISHIKAWA Takeji (50051579)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. AMAGAI Masayuki (90212563)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. TOMITA Masato (90296608)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. SHIMADA Shinji (10114505)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. SAIDA Toshiaki (10010381)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. IWAI Takehisa (90111591)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. KITAJIMA Masaki (90112672)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. KUWANA Masataka (50245479)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 千葉滋 (60212049)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 池田英之 (40301494)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 長谷川豪 (80383751)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SAKURAI Toshiharu 桜井 敏晴

Research Projects

Research Products

Co-Researchers

Elucidation of the condition of construction mechanisms of immunity on sentinel lymph nodes of patients with melanoma and development of novel immunotherapyPrincipal Investigator

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Development of effective immunotherapy by combining interventions on key points in the anti-tumor immune network

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Elucidation of the resistance mechanisms of immunotherapy by the abnormal signal transduction in melanoma and development of methods to overcome itPrincipal Investigator

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Development of effective immunotherapy by combining methods to restore immunocompetence of cancer patients

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The study of immunosuppressive mechanisms induced by gastrointestinal cancer during epithelial-mesnchymal transition and clinical application of this target therapyPrincipal Investigator

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Development of immunotherapy based on the identification of tumor antigens

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Identification of novel autoantigens using human IgG in SCID mice implanted with lacrimal and salivary grands from patients with Sjogren's SyndromePrincipal Investigator

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Development of new diagnostic and immunotherapeutic methods for patients with cancer

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Using soluble HLA-peptide tetramer, the studies on the cloning and immune-response monitoring of melanoma antigen-specific cytotoxic lymphocytePrincipal Investigator

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メラノーマに対する新しい免疫療法の開発

Principal Investigator

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Systematic isolation of genes encoding candidate proteins for human melanoma antigens using serial analysis of gene expression (SAGE) and EST database

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Development of diagnositic and therapeutic methods using frameshift mutated peptides for colorectal cancers with microsatellite instability

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Using solubel peptide-MHC tetramer, the trial of staining and cloning the melanoma antigen-specific cytotoxic lymphocytesPrincipal Investigator

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SAKURAI Toshiharu 桜井敏晴

[Journal Article] 【がん免疫学と免疫療法の新展開】がん免疫病態と免疫動態の評価2012