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Otaka Akira  大高 章

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OTAKA Akira  大高 章

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Researcher Number 20201973
Other IDs
External Links
Affiliation (Current) 2025: 徳島大学, 大学院医歯薬学研究部(薬学域), 教授
Affiliation (based on the past Project Information) *help 2023 – 2024: 徳島大学, 大学院医歯薬学研究部(薬学域), 教授
2017 – 2021: 徳島大学, 大学院医歯薬学研究部(薬学域), 教授
2016 – 2018: 徳島大学, 大学院医歯薬学研究部(薬学系), 教授
2015 – 2016: 徳島大学, 大学院医歯薬学研究部, 教授
2011 – 2014: 徳島大学, ヘルスバイオサイエンス研究部, 教授 … More
2005 – 2013: The University of Tokushima, Institute of Health Biosciences, Professor, 大学院・ヘルスバイオサイエンス研究部, 教授
2007: The University of Tokushima, 大学院・ヘルスバイオサイエンス研究院, 教授
2007: The University of Tokushima, 大学院・ヘルスバイオサイエン研究部, 教授
2005 – 2006: 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授
1997 – 2004: Kyoto University, Graduated School of Pharmaceutical Sciences, Asociate Professo, 薬学研究科, 助教授
2001: Graduate School of Pharmaceutical Sciences, Kyoto University, Asoc. Professor, 薬学研究科(研究院), 助教授
1999: 京都大学, 大学院・薬学研究科, 助教授
1997: 京都大学, 大学院・薬学研究科, 助教授
1995 – 1996: 京都大学, 薬学部, 助教授
1993 – 1994: 京都大学, 薬学部, 助手
1990 – 1991: 京都大学, 薬学部, 助手 Less
Review Section/Research Field
Principal Investigator
Drug development chemistry / Chemical pharmacy / Science and Engineering / Medium-sized Section 47:Pharmaceutical sciences and related fields / Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related / Basic Section 47050:Environmental and natural pharmaceutical resources-related / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Pharmaceutical Sciences and related fields / Science and Engineering / Living organism molecular science / Chemical pharmacy / Biological Sciences … More
Except Principal Investigator
… More 医薬分子機能学 / Biological Sciences / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Chemical pharmacy / Basic Section 47040:Pharmacology-related / Basic Section 54040:Metabolism and endocrinology-related / Medium-sized Section 47:Pharmaceutical sciences and related fields / Tumor biology and related fields / Pathological medical chemistry / Chemical pharmacy / Physical pharmacy / Drug development chemistry / Digestive surgery Less
Keywords
Principal Investigator
ペプチド合成 / ペプチド / リン酸化ペプチド / チオエステル / 最終脱保護 / リン酸化 / タンパク質 / アシル転移 / インテイン / 標的タンパク質 … More / 蛋白質 / スプライシング / ペプチドミメティック / ホスファターゼ抵抗性 / 細胞内情報伝達 / ホスファターゼ / 配列選択的反応 / SARS-CoV / α-helix / HIV-1 / Avidin-biotin / ジスルフィド結合 / N-Sアシル転移 / タンパク質化学合成 / NCL / 速度論的反応 / Native Chemical Ligation / 刺激応答型アミノ酸 / エクステイン / 膜融合 / 生体分子 / 有機化学 / 感染症 / ウイルス / ペプチドチオエステル / 非水解性リン酸化アミノ酸 / 有機銅試薬 / ジメチルホスフェートアミノ酸 / アルファー修飾ペプチド / イミン / 分子内Redox反応 / ロッセン転位 / グリオキシリルペプチド / サクチペプチド / グリシルヒドロキサム酸 / チロシン / トリプトファン / 側鎖修飾 / 保護システインスルホキシド / スルフェニル化 / スルホキシド / 保護システイン / 修飾反応 / S-アデノシルホモシステイン / 蛍光プローブ / アデノシルホモシステイン / 生体反応可視化 / 蛍光プローブ分子 / 生体内メチル化 / 配列特異的反応 / タンパク質ヒドラジド / タンパク質チオエステル / プロテアーゼ / タンパク質半合成 / タンパク性医薬品 / カルボキシペプチダーゼ / タンパク質修飾 / タンパク性医薬 / ペプチドヒドラジド / 抗体医薬 / アシル基転移反応 / peptide / anti-viral agents / membrane fusion / SARS / a-helix / 抗ウイルス剤 / samarium dienolate / one-electron reducing agent / samarium diiodide / dipeptide isosteres / fluoroalkene / organocopper reagents / ヨウ価サマリウム / ジペプチドイスター / Sm-ジエノラート / 一電子還元剤 / ヨウ化サマリウム / ジペプチドイソスター / フルオロアルケン / 不斉補助基 / クロスカップリング反応 / dimethylphosphono amino acids / final deprotection / peptide synthesis / phosphopeptides / phosphoamino acid / フラグメント結合 / Affinity purification / Defensin / Protegrin / Self-defense peptide / Disulfide bond / Solid-phase synthesis / アフィニティークロマト / デフェンシン / プロテグリン / 生体防御ペプチド / 固相合成 / ケミカルバイオロジー / タンパク質ラベル化 / ラベル化 / アミド結合切断 / ビオチン / アビジン / 速度論支配 / タンパク質合成 / 速度論的支配 / デグロン / ペプチド等価体 / タンパク濃縮 / ホスファターゼ抵抗性リン酸化アミノ酸 / ペプチド結合切断 / 外部刺激応答型アミノ酸 / タンパク質機能 / アミド結合 / アシル転位 / 不溶性膜タンパク質 / 膜蛋白質 / イシテイン / 光切断型保護基 / 膜タンパク質 / 不溶性蛋白質 / 細胞周期 / リン酸化アミノ酸 / パラジウム触媒 / 還元的アルキル化 / ボンベシン / GRP / (E)-アルケン型ジペプチドイソスター / ペプチドリード医薬品 / GRP拮抗剤 / アルケン / ペプチドイソスター … More
Except Principal Investigator
膜融合阻害剤 / ペプチド化学 / 癌 / 環状ペプチド / T140 / CXCR4アンタゴニスト / tumor suppressor / breast cancer / タンパク質 / drug discovery / プロテオーム / ゲノム / Constitutively Active Receptor Technology / CXCR4拮抗剤 / HIVプロテアーゼ阻害剤 / エイズ / 立体配座固定 / ペプチドイソスター / Bombesin Antagonist / 抗腫瘍活性 / ボンベシンアンタゴニスト / 有機銅試薬 / 創薬 / 低分子化 / de novo設計 / T細胞指向性HIV-1 / HIV侵入阻害剤 / 脂質膜 / gp41 / CXCR4 / ペプチドチオエステル / 基質遷移状態模倣型酵素阻害剤 / aza-Payne転位反応 / Plasmepsin II / マラリア / アポトーシス / 阻害剤 / MAPキナーゼ・キナーゼ / MAPキナーゼ / ヒトがん細胞 / 細胞がん化 / 大腸癌制御メカニズム解明 / 大腸がん / EP4受容体 / GIP / GLP-1 / インクレチン / タンパク質間相互作用 / プロテオミクス解析 / クロスリンク質量分析法 / タンパク質ラベル化 / Native Chemical Ligation / タンパク質ライブラリ / タンパク質化学合成 / 翻訳後修飾 / タンパク質化学 / ネイティブケミカルライゲーション / タンパク質半合成 / HER2 / がん特異的発現亢進因子 / がん抑制因子 / ミトコンドリア / 乳がん / タンパク相互作用阻害 / multistep carcinogenesis / 生体機能利用 / mitochondrial regulation / oncogenic signaling / dephosphorylation / phosphorylation / estrogen signaling / 刺激応答型アミノ酸 / 活性制御 / ペプチド結合切断 / アミド結合切断 / ラクトン化 / 刺激応答 / ペプチド / 機能制御 / トリメチルロック / ABCトランスポーター / アミロイドーシス / 脂質異常症 / コレステロール代謝 / HDL / 糖鎖 / アミロイド / 抗体 / コンフォメーション / HDL / アポリポタンパク質 / G-protein coupled receptor / chemical ligation / CXCR4 antagonist / Peptide Chemistry / peptide-isosteres / genome science / ユニバーサル創薬テンプレート / αVβ3-integrin / 7TM-GPCR / SARS Corona Virus / リウマチ / Germinal Center / HIV感染 / 7回膜貫通型レセプター / 創薬テンプレート / 蛋白質化学 / ゲノム情報 / 7回膜貫通型GPCR / Chemical Ligation / 創薬研究 / ゲノム科学 / de novo design / HIV-cell fusion inhibitors / low molecular weight CXCR4 antagonists / T-cell line-tropic HIV / chemokine receptor / anti-HIV agents / 有用金属試薬 / コンビナトリアル合成 / エイス / 逆転写酵素阻害 / T140立体構造 / CXCR4ケモカイン受容体 / HIV第二受容体拮抗剤 / 二価官能性抗HIV剤 / 多剤耐性克服型抗HIV剤 / HIV-cell融合阻害剤 / spring8 / SC34EK / gp41-標的型HIV-Cell膜融合阻害剤 / FC131 / T140-CXCR4ドッキング解析 / 機能性CXCR4変異体 / ホモロジーモデリング / 環状ペンタペプチドライブラリー / de novo分子設計 / 多剤耐性HIV / T細胞指向性HIV / CXCR4ケモカインレセプター / HIV進入阻害剤 / Alkene-type tipeptide isostere / Organocopper Reagent / HIV-protease / β-Secretase / aza-Payne Rearrangement / Substrate Transition State Mimic / Aspartyl Protease / Stereoselective Synthesis / ケモカインアンタゴニスト / 遷移金属触媒 / 基質遷移状態ミミック構造 / 非天然型アミノ酸誘導体 / (E)-Alkcnc型dipcptidcisostcrc / オレフィンメタセシス閉環反応 / 多剤耐性HIV型プロテアーゼ / β-secretase / グローバル配座固定 / Ru-触媒メタセシス閉環反応 / ペプチドリード医薬品 / 有機亜鉛-銅複合試薬 / アルツハイマー型痴呆症 / αVβ3インテグリン拮抗剤剤 / ゲノム情報集約型ライブラリー / アルケン型ジペプチドイソスター / HIVプロテアーゼ / β-セクレターゼ / aza-Payne転位 / 基質遷移状態模倣型阻害剤 / アスパルチルプロテアーゼ / 立体的選択的合成反応 / Allylpalladium Complex / Organopalladium Compound / Vinylaziridine / Aziridinylenoate / Alkene Isostere / SN2-type Ring-Opening / Organocopper Compound / トリプトフアン・イソスター / トリプトファン・イソスター / アリルパラジウム錯体 / 有機パラジウム化合物 / ビニルアジリジン / アジリジニル・エノエイト / アルケンイソスター / SN2型開環反応 / ボンベシン・アンタゴニスト / 有機銅化合物 / Stereocontrolled Synthetic Route / Anti-Cancer Activity / Inhibition of Amylase Release / (E)-Alkene Dipeptide Isosters / Palladium(0) / Activated Aziridinyl Enoates / Organocopper Reagents / 膵癌細胞増殖抑制 / 遷移金属触媒による異性化反応 / (E)-アルケン型ジペプチドイソスター / 立体特異的1,3-不斉転移 / キラルプール / 立体制御合成プロセス / アミラーゼ分泌抑制 / (E)-アルケンジペプチドイソスター / 0価パラジウム / 活性化アジリジンエノエ-ト / Fmoc-Based Solid Phase Synthesis / Trans olefin type isostere / organocopper-Lewis Acid Complex / Inhibitor / Aspartyl protease / AIDS Virus / アルパルチルプロテア-ゼ / Fmoc型固相法 / トランスオレフィン型イソスタ- / 有機銅ールイス酸複合剤 / アスパルチルプロテア-ゼ / エイズウイルス / 標的タンパク同定 / クリックケミストリー / 光親和性標識 / ビオチン / 細胞毒性 / アスパーギライド / プルダウンアッセイ / 細胞接着 / 標的タンパク質 / プロテオミクス / プルダウン法 / ベイト分子 / ケミカルバイオロジー / 標的タンパク / 不斉合成 / 天然物 / 非ペプチド化 / リポソーム / HIV / タンパク質合成 / 脂質二重膜 / 膜タンパク質 / 受容体 / ケモカインレセプター / X線結晶解析 / 人工設計 / SC34 / 6 helical bundle構造 / de novoデザイン / 薬剤耐性型抗HIV剤 / 6-helical bundle構造 / HIV外皮蛋白質gp41 / 膵癌 / 遺伝子治療 / アンチセンス・オリゴヌクレオチド / Bcl-X遺伝子 / p16 / トロージャンペプチド / マラリアワクチン / Duffy-結合様ドメイン / ChondroitinsulfateA / Plasmodium falciparum / pp125^<FAK> / 増殖阻害 / MEK阻害剤 / フラボン / Ras Less
  • Research Projects

    (51 results)
  • Research Products

    (392 results)
  • Co-Researchers

    (47 People)
  •  コンディショナルプロテオミクスの課題を克服するラジカル再結合型ラベル化試薬の創出

    • Principal Investigator
      重永 章
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
    • Research Institution
      Fukuyama University
  •  相互作用タンパク質の同定・トポロジー解析を指向した光活性型クロスリンカーの開発

    • Principal Investigator
      傳田 将也
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
    • Research Institution
      The University of Tokushima
  •  GIP/GLP-1受容体共刺激による血糖降下・体重減少作用増強メカニズムの解明

    • Principal Investigator
      稲垣 暢也
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      The Tazuke Kofukai
  •  Development of a method for modifying peptides using cation-generating sulfoxidesPrincipal Investigator

    • Principal Investigator
      大高 章
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
      Basic Section 47050:Environmental and natural pharmaceutical resources-related
      Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related
    • Research Institution
      The University of Tokushima
  •  Innovation of synthesizing alpha-oxidized peptide enabled by Lossen rearrangementPrincipal Investigator

    • Principal Investigator
      大高 章
    • Project Period (FY)
      2023 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 47:Pharmaceutical sciences and related fields
    • Research Institution
      The University of Tokushima
  •  プロスタノイドEP4受容体の恒常的活性による細胞増殖速度調整メカニズムの解明

    • Principal Investigator
      藤野 裕道
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47040:Pharmacology-related
    • Research Institution
      The University of Tokushima
  •  Protein semi-synthesis-based construction of protein library with diversity in post-translational modification

    • Principal Investigator
      Shigenaga Akira
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 47:Pharmaceutical sciences and related fields
    • Research Institution
      Fukuyama University
  •  Development of fluorescence probe for visualization of in-cell methylation eventsPrincipal Investigator

    • Principal Investigator
      OTAKA Akira
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Research Field
      Pharmaceutical Sciences and related fields
    • Research Institution
      The University of Tokushima
  •  Drug discovery in breast cancer utilizing reactivation of tumor suppressors

    • Principal Investigator
      KATAGIRI Toyomasa
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Research Field
      Tumor biology and related fields
    • Research Institution
      The University of Tokushima
  •  Development of methods for modification of proteins with its application to protein drugsPrincipal Investigator

    • Principal Investigator
      OTAKA Akira
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Drug development chemistry
    • Research Institution
      The University of Tokushima
  •  Clarification of novel pathophysiological roles of BIG3 in breast cancer cells

    • Principal Investigator
      KATAGIRI Toyomasa
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      The University of Tokushima
  •  Synthetic Study on Semi-synthetic AntibodyPrincipal Investigator

    • Principal Investigator
      OTAKA Akira
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Drug development chemistry
    • Research Institution
      The University of Tokushima
  •  Development of a stimulus-responsive amino acid that enables functional control of peptides and proteins

    • Principal Investigator
      SHIGENAGA Akira
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      The University of Tokushima
  •  Development of highly efficient labelling reagents for proteinPrincipal Investigator

    • Principal Investigator
      OTAKA Akira
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Drug development chemistry
    • Research Institution
      The University of Tokushima
  •  Physicochemical mechanism on formation and metabolism of HDL particles by apolipoproteins

    • Principal Investigator
      Saito Hiroyuki
    • Project Period (FY)
      2013 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Physical pharmacy
    • Research Institution
      Kyoto Pharmaceutical University
      The University of Tokushima
  •  分子標的探索のための化学選択的修飾部位内在型リンカーの開発Principal Investigator

    • Principal Investigator
      大高 章
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Science and Engineering
    • Research Institution
      The University of Tokushima
  •  Development of synthetic platoform of proteinsPrincipal Investigator

    • Principal Investigator
      OTAKA Akira
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      The University of Tokushima
  •  Development and application of efficient identification method for drugable proteins based on natural products and bioorganic chemistries

    • Principal Investigator
      SHISHIDO Kozo
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      The University of Tokushima
  •  Development of methodology forchemical synthesis of proteins based on kinetically controlled peptide bond formationPrincipal Investigator

    • Principal Investigator
      OTAKA Akira
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Drug development chemistry
    • Research Institution
      The University of Tokushima
  •  Development of methodologies for catalytic decomposition of proteinsPrincipal Investigator

    • Principal Investigator
      OTAKA Akira
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      The University of Tokushima
  •  化学的アミド結合切断を基盤とする時空間制御型タンパク質機能発現調節法の開発Principal Investigator

    • Principal Investigator
      大高 章
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Living organism molecular science
    • Research Institution
      The University of Tokushima
  •  ウイルスの共通分子機構を標的とする抗ウイルスペプチドの開発戦略の創製Principal Investigator

    • Principal Investigator
      大高 章
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Science and Engineering
    • Research Institution
      The University of Tokushima
  •  Davelopment of methodology for the preparation of membrane proteinsPrincipal Investigator

    • Principal Investigator
      OTAKA Akira
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Chemical pharmacy
    • Research Institution
      The University of Tokushima
  •  ウイルスの共通分子機構を標的とする抗ウイルスペプチドの開発戦略の創製Principal Investigator

    • Principal Investigator
      大高 章
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Science and Engineering
    • Research Institution
      The University of Tokushima
  •  CXCR4とgp41をダブルターゲットとした人工設計型HIV侵入阻害剤の創製研究

    • Principal Investigator
      玉村 啓和
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  人工スプライシングシステムの構築と不溶性蛋白質合成への展開Principal Investigator

    • Principal Investigator
      大高 章
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Drug development chemistry
    • Research Institution
      Kyoto University
  •  Development of anti-HIV-1 peptides based on the concept of the discrimination of helical surfacesPrincipal Investigator

    • Principal Investigator
      OTAKA Akira
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      The University of Tokushima
      Kyoto University
  •  HIV外皮蛋白断片gp41-C34を基にした人工設計型細胞融合阻害剤の創製研究

    • Principal Investigator
      玉村 啓和
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  ケミカルレセプトームの開発と応用

    • Principal Investigator
      藤井 信孝
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      医薬分子機能学
    • Research Institution
      Kyoto University
  •  Genome/Proteome-lead Drug Discovery Based on Peptide/Protein Chemistry

    • Principal Investigator
      FUJII Nobutaka
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      医薬分子機能学
    • Research Institution
      Kyoto University
  •  HIV外皮蛋白断片gp41-C34を基にした人工設計型細胞融合阻害剤の創製研究

    • Principal Investigator
      TAMAMURA Hirokazu
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  Synthesis of Fluoroalkene Dipeptide Isosteres Using Organocopper ReagentsPrincipal Investigator

    • Principal Investigator
      OTAKA Akira
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      KYOTO UNIVERSITY
  •  細胞周期調節機能を有するペプチドの創製と抗がん剤への展開研究Principal Investigator

    • Principal Investigator
      大高 章
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  非ウイルス性ベクターによる膵癌治療法の開発

    • Principal Investigator
      HOSOTANI Ryo
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Digestive surgery
    • Research Institution
      Kyoto University
  •  DEVELOPMENT OF NOVEL ANTI -HIV AGENTS BASED ON HIGHLY' SELECTIVE CHEMOKINE RECEPTOR CXCR$ ANTAGONISTS

    • Principal Investigator
      FUJII Nobutaka
    • Project Period (FY)
      2000 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      医薬分子機能学
    • Research Institution
      KYOTO UNIVERSITY
  •  マラリア原虫の増殖機構をターゲットとする新規マラリア治療薬の開発研究

    • Principal Investigator
      藤井 信孝
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Kyoto University
  •  (E)-アルケンペプチドイソスターを探索子とする高活性GRP拮抗剤の創製Principal Investigator

    • Principal Investigator
      大高 章
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Kyoto University
  •  Studies on Practical Strategy for Peptide-lead Drug Discovery and Development

    • Principal Investigator
      FUJII Nobutaka
    • Project Period (FY)
      1998 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      医薬分子機能学
    • Research Institution
      KYOTO UNIVERSITY
  •  Synthesis of secondary difluoromethylphosphonate-contaning amino acid and its biological examinationPrincipal Investigator

    • Principal Investigator
      OTAKA Akira
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      KYOTO UNIVERSITY
  •  生体内情報伝達機構解明を指向したホスファターゼ抵抗性リン酸化ペプチドの合成Principal Investigator

    • Principal Investigator
      大高 章
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto University
  •  ヒトがん細胞におけるMAPキナーゼカスケードの異常-細胞がん化との相関

    • Principal Investigator
      河野 通明
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Nagasaki University
  •  (E)-アルケンペプチドイソスターを探索子とする高活性GRP拮抗剤の創製Principal Investigator

    • Principal Investigator
      大高 章
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto University
  •  Development of highly efficient, selective, and practical synthetic method of pseudo-peptides possessing anti-tumour activity.

    • Principal Investigator
      FUJII Nobutaka, 井深 俊郎
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Chemical pharmacy
    • Research Institution
      KYOTO UNIVERSITY
  •  生体内情報伝達機構解明を指向したホスファターゼ抵抗性リン酸化ペプチドの合成Principal Investigator

    • Principal Investigator
      大高 章
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto University
  •  MAPキナーゼカスケードを構成するシグナル分子を標的とした細胞増殖阻害物質の検索

    • Principal Investigator
      河野 通明
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Gifu Pharmaceutical University
  •  Synthesis of Peptide Isosteres with Strong Bombesin Antagonist Activity and Its Development to Anti-Cancer Agents

    • Principal Investigator
      FUJII Nobutaka
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      医薬分子機能学
    • Research Institution
      KYOTO UNIVERSITY
  •  Development of Practical Synthetic Method for Phosphopeptides using Two-step Deprotecting ProceduresPrincipal Investigator

    • Principal Investigator
      OTAKA Akira
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      KYOTO UNIVERSITY
  •  生体内情報伝達機構解明を指向したホスファターゼ抵抗性リン酸化ペプチドの合成Principal Investigator

    • Principal Investigator
      大高 章
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto University
  •  新規最終脱保護系を用いた高効率リン酸化ペプチドの合成法の開発に関する研究Principal Investigator

    • Principal Investigator
      大高 章
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Kyoto University
  •  Development of efficient synthetic methods for peptides and syntheses of self-defense peptides possessing anti-virus activityPrincipal Investigator

    • Principal Investigator
      OTAKA Akira
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      KYOTO UNIVERSITY
  •  Deveropment of the Anti-AIDS Drug Based on the Aspartyl Protease Inhbitor

    • Principal Investigator
      FUNAKOSHI Susumu
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Kyoto University

All 2024 2023 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2004 2003 Other

All Journal Article Presentation Book

  • [Book] 医療・診断をささえるペプチド科学―再生医療・DDS・診断への応用―2017

    • Author(s)
      大高 章、重永 章
    • Total Pages
      7
    • Publisher
      株式会社 シーエムシー出版
    • ISBN
      9784781312675
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Book] 「生物活性小分子の結合パートナータンパク質を知りたい -リンカー分子を用いたタンパク質精製法-」実験医学増刊号 驚愕の代謝システム~メタボロームの階層から解き明かす疾患研究の新たなステージ~2014

    • Author(s)
      重永 章、山本 純、大高 章
    • Total Pages
      204
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-24390026
  • [Book] 「生物活性小分子の結合パートナータンパク質を知りたい -リンカー分子を用いたタンパク質精製法-」実験医学増刊号 驚愕の代謝システム~メタボロームの階層から解き明かす疾患研究の新たなステージ~2014

    • Author(s)
      重永 章、山本 純、大高 章
    • Total Pages
      204
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-25670058
  • [Book] 生体有機化学・12章 生理活性ペプチドホルモン2012

    • Author(s)
      大高 章
    • Publisher
      東京化学同人
    • Data Source
      KAKENHI-PROJECT-23390026
  • [Book] 刺激応答型アミノ酸の開発と生命科学分野への応用」遺伝子医学 MOOK 21 号 最新ペプチド合成技術とその創薬研究への応用2012

    • Author(s)
      重永 章、山本 純、大高 章
    • Publisher
      メディカルドゥ
    • Data Source
      KAKENHI-PROJECT-23659055
  • [Book] 生体有機化学・12章 生理活性ペプチドホルモン2012

    • Author(s)
      大高 章
    • Publisher
      東京化学同人
    • Data Source
      KAKENHI-PUBLICLY-24102521
  • [Book] 「第12 章 生理活性ペプチドホルモン」生体有機化学2012

    • Author(s)
      大高 章
    • Publisher
      東京化学同人
    • Data Source
      KAKENHI-PROJECT-23659055
  • [Book] 生体有機化学・12章 生理活性ペプチドホルモン2012

    • Author(s)
      大高 章
    • Publisher
      東京化学同人
    • Data Source
      KAKENHI-PROJECT-24390026
  • [Book] 生体有機化学・12章 生理活性ペプチドホルモン2012

    • Author(s)
      大高 章
    • Publisher
      東京化学同人
    • Data Source
      KAKENHI-PROJECT-23659055
  • [Book] 刺激応答型アミノ酸の開発と生命科学分野への応用2012

    • Author(s)
      重永章、山本純、大高章
    • Publisher
      メディカルドゥ
    • Data Source
      KAKENHI-PROJECT-21390031
  • [Book] 刺激応答型アミノ酸の開発と生命科学分野への応用, 遺伝子医学MOOK 21 号 最新ペプチド合成技術とその創薬研究への応用(木曽良明 編)2012

    • Author(s)
      重永 章, 山本 純, 大高 章
    • Publisher
      メディカルドゥ
    • Data Source
      KAKENHI-PROJECT-23390026
  • [Book] 第10章最近のペプチド・タンパク質の化学合成について2010

    • Author(s)
      大高章、重永章
    • Publisher
      建帛社
    • Data Source
      KAKENHI-PROJECT-21390031
  • [Book] 機能性タンパク質・ペプチドの生体利用(第10章 最近のペプチド・タンパク質の化学合成について)2010

    • Author(s)
      大高章
    • Total Pages
      27
    • Publisher
      建帛社
    • Data Source
      KAKENHI-PROJECT-21390031
  • [Book] 新しい薬をどう創るか(ブルーバックス)2008

    • Author(s)
      大高 章, 他京都大学大学院薬学研究科編
    • Publisher
      講談社
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Book] 新しい薬をどう創るか(ブルーバックス)2008

    • Author(s)
      大高 章, 他京都大学大学院薬学研究科編
    • Publisher
      講談社
    • Data Source
      KAKENHI-PROJECT-19651096
  • [Journal Article] Advanced Insulin Synthesis by One-pot/Stepwise Disulfide Bond Formation Enabled by S-Protected Cysteine Sulfoxide.2024

    • Author(s)
      Hidaka, K.; Kobayashi, D.; Hayashi, J.; Denda, M.; Otaka, A.
    • Journal Title

      Chemistry European Journal

      Volume: - Issue: 39

    • DOI

      10.1002/chem.202401003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23K18187, KAKENHI-PROJECT-23K27300
  • [Journal Article] Residue‐Selective C-H Sulfenylation Enabled by Acid‐Activated‐Acetamidomethyl Cysteine Sulfoxide with Application to One‐Pot Stapling and Lipidation Sequence2023

    • Author(s)
      Ohkawachi Kento、Anzaki Kaito、Kobayashi Daishiro、Kyan Ryuji、Yasuda Takuma、Denda Masaya、Harada Norio、Shigenaga Akira、Inagaki Nobuya、Otaka Akira
    • Journal Title

      Chemistry A European Journal

      Volume: - Issue: 26

    • DOI

      10.1002/chem.202300799

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21J14744, KAKENHI-PROJECT-23K18187, KAKENHI-PROJECT-22K15253, KAKENHI-PROJECT-23K27300
  • [Journal Article] Copper-mediated deprotection of thiazolidine and selenazolidine derivatives applied to native chemical ligation2020

    • Author(s)
      Naoto Naruse, Daishiroh Kobayashi, Kento Ohkawachi, Akira Shigenaga and Akira Otaka
    • Journal Title

      The Journal of Organic Chemistry

      Volume: 85 Issue: 3 Pages: 1425-1433

    • DOI

      10.1021/acs.joc.9b02388

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-17J03475
  • [Journal Article] Development of a 1,3a,6a-Triazapentalene Derivative as a Compact and Thiol-specific Fluorescent Labeling Reagent2020

    • Author(s)
      Atsushi Nakayama, Akira Otani, Tsubasa Inokuma, Daisuke Tsuji, Haruka Mukaiyama, Akira Nakayama, Kohji Itoh, Akira Otaka, Keiji Tanino, and Kosuke Namba
    • Journal Title

      Communications Chemistry

      Volume: 3 Issue: 1 Pages: 1-9

    • DOI

      10.1038/s42004-019-0250-0

    • NAID

      120006877882

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-15H05842, KAKENHI-PUBLICLY-18H04416, KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-17H04102, KAKENHI-PROJECT-18H01970, KAKENHI-PROJECT-19H02851, KAKENHI-PROJECT-17K08365, KAKENHI-PROJECT-18K14869, KAKENHI-PROJECT-18K06658
  • [Journal Article] Sequence-Independent Traceless Method for Preparation of Peptide/Protein Thioesters Using CPaseY-Mediated Hydrazinolysis2020

    • Author(s)
      Ueda Masahiro、Komiya Chiaki、Arii Sayuki、Kusumoto Kohshi、Denda Masaya、Okuhira Keiichiro、Shigenaga Akira、Otaka Akira
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 68 Issue: 12 Pages: 1226-1232

    • DOI

      10.1248/cpb.c20-00674

    • NAID

      130007948412

    • ISSN
      0009-2363, 1347-5223
    • Year and Date
      2020-12-01
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K21483, KAKENHI-PROJECT-20H04124
  • [Journal Article] Deprotection of S-acetamidomethyl cysteine with copper(ii) and 1,2-aminothiols under aerobic conditions2020

    • Author(s)
      Kobayashi Daishiro、Naruse Naoto、Denda Masaya、Shigenaga Akira、Otaka Akira
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 18 Issue: 42 Pages: 8638-8645

    • DOI

      10.1039/d0ob01475c

    • NAID

      120007132278

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K21483
  • [Journal Article] Development of a Turn-On Fluorescent Traceable Linker Employing <i>N</i>-Sulfanylethylcoumarinyl Amide for the Enrichment and Visualization of Target Proteins2020

    • Author(s)
      Takuya Morisaki, Akira Shigenaga and Akira Otaka
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 68 Issue: 3 Pages: 216-219

    • DOI

      10.1248/cpb.c19-00726

    • NAID

      130007804108

    • ISSN
      0009-2363, 1347-5223
    • Year and Date
      2020-03-01
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Journal Article] A Photo-Activatable Peptide Mimicking Functions of Apolipoprotein A-I2019

    • Author(s)
      Haruka Kawahara, Naoki Miyashita, Kohki Tachibana, Yusuke Tsuda, Kyohei Morimoto, Kouhei Tsuji, Akira Shigenaga, Akira Otaka, Tatsuhiro Ishida and Keiichiro Okuhira
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 42 Issue: 6 Pages: 1019-1024

    • DOI

      10.1248/bpb.b19-00114

    • NAID

      130007657697

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2019-06-01
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-16K08236
  • [Journal Article] Traceless synthesis of protein thioesters using enzyme-mediated hydrazinolysis and subsequent self-editing of cysteinyl prolyl sequence2019

    • Author(s)
      Chiaki Komiya, Akira Shigenaga, Jun Tsukimoto, Masahiro Ueda, Takuya Morisaki, Tsubasa Inokuma, Kouji Itou and Akira Otaka
    • Journal Title

      Chemical Communications

      Volume: 55 Issue: 49 Pages: 7029-7032

    • DOI

      10.1039/c9cc03583d

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-17H04102
  • [Journal Article] Asymmetric Synthesis of α-Amino Phosphonic Acids Using Stable Imino Phosphonate as a Universal Precursor.2019

    • Author(s)
      Inokuma, T.; Sakakibara, T.; Someno, T.; Masui, K.; Shigenaga, A.; Otaka, A.; Yamada, K.
    • Journal Title

      Chem. Eur. J.

      Volume: 25 Issue: 60 Pages: 13829-13832

    • DOI

      10.1002/chem.201903572

    • NAID

      120006886354

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06579, KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-18K14869
  • [Journal Article] A Recyclable Hydrophobic Anchor-Tagged Asymmetric Amino Thiourea Catalyst2018

    • Author(s)
      Jichu Takahisa、Inokuma Tsubasa、Aihara Keisuke、Kohiki Taiki、Nishida Kodai、Shigenaga Akira、Yamada Ken-ichi、Otaka Akira
    • Journal Title

      ChemCatChem

      Volume: 10 Issue: 16 Pages: 3402-3405

    • DOI

      10.1002/cctc.201800714

    • NAID

      120006652009

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06579, KAKENHI-PROJECT-18K14869, KAKENHI-PROJECT-17K19492
  • [Journal Article] Direct Enantioselective Indolylation of Peptidyl Imine for the Synthesis of Indolyl Glycine-Containing Peptides2018

    • Author(s)
      Inokuma, T.; Nishida, K.; Shigenaga, A.; Yamada, K.; Otaka, A.
    • Journal Title

      HETEROCYCLES

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Journal Article] Resin-bound crypto thioester for native chemical ligation2018

    • Author(s)
      Naruse, N.; Ohakawachi, K.; Inokuma, T.; Shigenaga, A.; Otaka, A.
    • Journal Title

      Organic Letters

      Volume: 20 Issue: 8 Pages: 2449-2453

    • DOI

      10.1021/acs.orglett.8b00795

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17J03475, KAKENHI-PROJECT-16H02611
  • [Journal Article] Light-induced propulsion of a giant liposome driven by peptide nanofibre growth2018

    • Author(s)
      Inaba Hiroshi、Uemura Akihito、Morishita Kazushi、Kohiki Taiki、Shigenaga Akira、Otaka Akira、Matsuura Kazunori
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 6243-6243

    • DOI

      10.1038/s41598-018-24675-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Journal Article] Protein Synthetic Chemistry Inspired by Intein-mediated Protein Splicing2018

    • Author(s)
      Otaka Akira、Shigenaga Akira
    • Journal Title

      Journal of Synthetic Organic Chemistry, Japan

      Volume: 76 Issue: 1 Pages: 45-54

    • DOI

      10.5059/yukigoseikyokaishi.76.45

    • NAID

      130006313519

    • ISSN
      0037-9980, 1883-6526
    • Language
      Japanese
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Journal Article] Direct Enantioselective Indolylation of Peptidyl Imine for the Synthesis of Indolyl Glycine-Containing Peptides2018

    • Author(s)
      Otaka Akira、Yamada Ken-ichi、Inokuma Tsubasa、Nishida Kodai
    • Journal Title

      HETEROCYCLES

      Volume: 97 Issue: 2 Pages: 1269-1269

    • DOI

      10.3987/com-18-s(t)86

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06579, KAKENHI-PROJECT-17K19492
  • [Journal Article] ピンサー型錯体 有機カルコゲン化合物 曲面π共役分子 Native Chemical Ligation法2018

    • Author(s)
      大髙 章、重永 章
    • Journal Title

      Journal of Synthetic Organic Chemistry, Japan

      Volume: 76 Issue: 1 Pages: 66-66

    • DOI

      10.5059/yukigoseikyokaishi.76.66

    • NAID

      130006313514

    • ISSN
      0037-9980, 1883-6526
    • Language
      Japanese
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Journal Article] Effect of Phosphatidylserine and Cholesterol on Membrane-mediated Fibril Formation by the N-terminal Amyloidogenic Fragment of Apolipoprotein A-I2018

    • Author(s)
      Mizuguchi Chiharu、Nakamura Mitsuki、Kurimitsu Naoko、Ohgita Takashi、Nishitsuji Kazuchika、Baba Teruhiko、Shigenaga Akira、Shimanouchi Toshinori、Okuhira Keiichiro、Otaka Akira、Saito Hiroyuki
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 5497-5497

    • DOI

      10.1038/s41598-018-23920-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-16J01828, KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-17H03979, KAKENHI-PROJECT-17K19492, KAKENHI-PROJECT-17K16123
  • [Journal Article] ProteoFind: A script for finding proteins that are suitable for chemical synthesis2018

    • Author(s)
      Shigenaga, A.; Naruse, N.; Otaka, A.
    • Journal Title

      Tetrahedron

      Volume: 74 Issue: 19 Pages: 2291-2297

    • DOI

      10.1016/j.tet.2018.03.030

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17J03475, KAKENHI-PROJECT-15K07858, KAKENHI-PROJECT-16H02611
  • [Journal Article] CXCL14 Acts as a Specific Carrier of CpG DNA into Dendritic Cells and Activates Toll-like Receptor 9-mediated Adaptive Immunity2017

    • Author(s)
      Tanegashima Kosuke、Takahashi Rena、Nuriya Hideko、Iwase Rina、Naruse Naoto、Tsuji Kohei、Shigenaga Akira、Otaka Akira、Hara Takahiko
    • Journal Title

      EBioMedicine

      Volume: 24 Pages: 247-256

    • DOI

      10.1016/j.ebiom.2017.09.012

    • NAID

      120006941113

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-16H04728, KAKENHI-PROJECT-17J03475
  • [Journal Article] An aromatic amino acid within intracellular loop 2 of the prostaglandin EP2 receptor is a prerequisite for selective association and activation of Gαs.2017

    • Author(s)
      Yano A, Takahashi Y, Moriguchi H, Inazumi T, Koga T, Otaka A, Sugimoto Y.
    • Journal Title

      Biochim Biophys Acta Mol Cell Biol Lipids

      Volume: 1862 Issue: 6 Pages: 615-622

    • DOI

      10.1016/j.bbalip.2017.03.006

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-ORGANIZER-15H05897, KAKENHI-PROJECT-15K19032, KAKENHI-PROJECT-15K18875, KAKENHI-PLANNED-15H05905, KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-17H03990, KAKENHI-PROJECT-26670030
  • [Journal Article] Stapled BIG3 helical peptide ERAP potentiates antitumour activity for breast cancer therapeutics.2017

    • Author(s)
      Yoshimaru T, Aihara K, Komatsu M, Matsushita Y, Okazaki Y, Toyokuni S, Honda J, Sasa M, Miyoshi Y, Otaka A, Katagiri T
    • Journal Title

      Scientific Reports

      Volume: 印刷中 Issue: 1 Pages: 1821-1821

    • DOI

      10.1038/s41598-017-01951-6

    • NAID

      120006535017

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26461948, KAKENHI-PROJECT-17K19492, KAKENHI-PUBLICLY-16H01575, KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-16H05153
  • [Journal Article] 第3章第3節 ペプチドの不安定性を解決するペプチド結合の置換技術2017

    • Author(s)
      大髙 章、鳴海 哲夫
    • Journal Title

      ペプチド医薬品のスクリーニング・安定化・製剤化技術(株式会社技術情報協会)

      Volume: - Pages: 130-140

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Journal Article] Elucidation of inhibitor-binding pocket of D-amino acid oxidase using docking simulation and N-sulfanylethylanilide-based labeling technology2017

    • Author(s)
      Taiki Kohiki, Yusuke Kato, Yusuke Nishikawa, Kazuko Yorita, Ikuko Sagawa, Masaya Denda, Tsubasa Inokuma, Akira Shigenaga*, Kiyoshi Fukui*, Akira Otaka*
    • Journal Title

      Org. Biomol. Chem. (Inside Front Cover)

      Volume: 15 Issue: 25 Pages: 5289-5297

    • DOI

      10.1039/c7ob90109g

    • NAID

      120006493365

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K07858
  • [Journal Article] Chemical Synthetic Platform for Chlorpromazine Oligomers That Were Reported as Photo-degradation Products of Chlorpromazine2017

    • Author(s)
      Kohiki Taiki、Nishikawa Yusuke、Inokuma Tsubasa、Shigenaga Akira、Otaka Akira
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 65 Issue: 12 Pages: 1161-1166

    • DOI

      10.1248/cpb.c17-00692

    • NAID

      130006235035

    • ISSN
      0009-2363, 1347-5223
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K19492, KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-15K07858
  • [Journal Article] Elucidation of inhibitor-binding pocket of D-amino acid oxidase using docking simulation and N-sulfanylethylanilide-based labeling technology2017

    • Author(s)
      Kohiki, T.; Kato, Y.; Nishikawa, Y.;Yorita, K.; Sagawa, I.; Denda, M.; Inokuma, T.; Shigenaga, A.; Fukui, K.; Otaka, A.
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 15 Issue: 25 Pages: 5289-5297

    • DOI

      10.1039/c7ob00633k

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K19492, KAKENHI-PROJECT-16H02611
  • [Journal Article] Invention of stimulus-responsive peptide-bond-cleaving residue (Spr) and its application to chemical biology tools2017

    • Author(s)
      Akira Shigenaga*, Jun Yamamoto, Taiki Kohiki, Tsubasa Inokuma, Akira Otaka*
    • Journal Title

      J. Pept. Sci. (Akabori Special Issue, Review)

      Volume: 23 Issue: 7-8 Pages: 505-513

    • DOI

      10.1002/psc.2961

    • NAID

      120006493367

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K07858
  • [Journal Article] A Convenient Method for Preparation of α-Imino Carboxylic Acid Derivatives and Application to the Asymmetric Synthesis of Unnatural α-Amino Acid Derivative2017

    • Author(s)
      Inokuma Tsubasa、Jichu Takahisa、Nishida Kodai、Shigenaga Akira、Otaka Akira
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 65 Issue: 6 Pages: 573-581

    • DOI

      10.1248/cpb.c17-00158

    • NAID

      130005686014

    • ISSN
      0009-2363, 1347-5223
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Journal Article] Stapled BIG3 helical peptide ERAP extends potent antitumor activity for breast cancer therapeutics2017

    • Author(s)
      Yoshimaru T*, Aihara K, Komatsu M, Matsushita Y, Okazaki Y, Toyokuni S, Honda J, Sasa M, Miyoshi Y, Otaka A, Katagiri T*
    • Journal Title

      Scientific Reports

      Volume: 印刷中

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05153
  • [Journal Article] Cysteine-Free Intramolecular Ligation of N-Sulfanylethylanilide Peptide Using 4-Mercaptobenzylphosphonic Acid: Synthesis of Cyclic Peptide Trichamide2017

    • Author(s)
      Otaka Akira、Aihara Keisuke、Inokuma Tsubasa、Jichu Takahisa、Lin Zhenjian、Fu Feixue、Yamaoka Kosuke、Shigenaga Akira、Hutchins David、Schmidt Eric
    • Journal Title

      Synlett

      Volume: 28 Issue: 15 Pages: 1944-1949

    • DOI

      10.1055/s-0036-1589055

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Journal Article] An N-Sulfanylethylanilide-based traceable linker for enrichment and selective labelling of target proteins2016

    • Author(s)
      Takuya Morisaki, Masaya Denda, Jun Yamamoto, Daisuke Tsuji, Kohji Itoh, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka
    • Journal Title

      Chemical Communications

      Volume: 52 Issue: 42 Pages: 6911-6913

    • DOI

      10.1039/c6cc01229a

    • NAID

      120006493363

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26293120, KAKENHI-PROJECT-15K07858, KAKENHI-PROJECT-15KK0309
  • [Journal Article] Labelling of endogenous target protein via N-S acyl transfer-mediated activation of N-sulfanylethylanilide2016

    • Author(s)
      Denda, M.; Morisaki, T.; Kohiki, T.; Yamamoto, J.; Sato, K.; Sagawa, I.; Inokuma, T.; Sato, Y.; Yamauchi, A.; Shigenaga, A.*; Otaka, A.*
    • Journal Title

      Org. Biomol. Chem.

      Volume: 14 Issue: 26 Pages: 6244-6251

    • DOI

      10.1039/c6ob01014h

    • NAID

      120006489009

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K07858, KAKENHI-PROJECT-16K21077
  • [Journal Article] Heparin promotes fibril formation by the N-terminal fragment of amyloidogenic apolipoprotein A-I2016

    • Author(s)
      Mikawa, S., Mizuguchi, C., Nishitsuji, K., Baba, T., Shigenaga,A., Shimanouchi, T., Sakashita, N., Otaka, A., Akaji, K., Saito, H.
    • Journal Title

      FEBS Letters

      Volume: 590(20) Issue: 20 Pages: 3492-3500

    • DOI

      10.1002/1873-3468.12426

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16J01828, KAKENHI-PROJECT-25293006, KAKENHI-PROJECT-15K19488, KAKENHI-PROJECT-16K08712
  • [Journal Article] Tailored synthesis of 162-residue S-monoglycosylated GM2-activator protein (GM2AP) analogues that allows access to protein library.2016

    • Author(s)
      Nakamura, T.; Sato, K.; Naruse, N.; Kitakaze, K.; Inokuma, T.; Hirokawa, T.; Shigenaga, A.; Itoh, K.; Otaka, A.
    • Journal Title

      ChemBioChem.

      Volume: 17 Issue: 20 Pages: 1986-1992

    • DOI

      10.1002/cbic.201600400

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-16J08106, KAKENHI-PROJECT-26293120, KAKENHI-PROJECT-15K14979, KAKENHI-PROJECT-16K21077
  • [Journal Article] N-Sulfanylethylaminooxybutyramide (SEAoxy): A Crypto-Thioester Compatible with Fmoc Solid-Phase Peptide Synthesis.2016

    • Author(s)
      Tsuda, S.; Mochizuki, M.; Sakamoto, K.; Denda, M.; Nishio, H.; Otaka, A.; Yoshiya, T.
    • Journal Title

      Org. Lett.

      Volume: 18 Issue: 22 Pages: 5940-5943

    • DOI

      10.1021/acs.orglett.6b03055

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-15K14979
  • [Journal Article] 天然アミノ酸配列に適用可能な新規タンパク質チオエステル合成法の開発2016

    • Author(s)
      津田雄介、重永 章、佐藤浩平、中村太寛、北風圭介、猪熊 翼、伊藤孝司、大髙 章
    • Journal Title

      ケミカルバイオロジー

      Volume: 9 Pages: 7-10

    • NAID

      40021146446

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K14979
  • [Journal Article] Facile Preparation of Peptides with C-Terminal <i>N</i>-Alkylamide <i>via</i> Radical-Initiated Dethiocarboxylation2016

    • Author(s)
      Shimizu, T.; Miyajima, R.; Naruse, N.; Yamaoka, K.; Aihara, K.; Shigenaga, A.*; Otaka, A.*
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 64 Issue: 4 Pages: 375-378

    • DOI

      10.1248/cpb.c15-01025

    • NAID

      130005141024

    • ISSN
      0009-2363, 1347-5223
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K07858, KAKENHI-PROJECT-14J07568, KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-15K14979
  • [Journal Article] One-pot/sequential native chemical ligation using photo-caged crypto-thioester2016

    • Author(s)
      Keisuke Aihara, Kosuke Yamaoka, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka
    • Journal Title

      Organic Letters

      Volume: 18 Issue: 3 Pages: 596-599

    • DOI

      10.1021/acs.orglett.5b03661

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K14979, KAKENHI-PROJECT-14J07568, KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-15K07858
  • [Journal Article] Development of an intein-inspired amide cleavage chemical device2016

    • Author(s)
      Komiya, C.; Aihara, K.; Morishita, K.; Ding, H.; Inokuma, T.; Shigenaga, A.; Otaka, A.*
    • Journal Title

      J. Org. Chem.

      Volume: 81 Issue: 2 Pages: 699-707

    • DOI

      10.1021/acs.joc.5b02399

    • NAID

      120006493349

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K07858, KAKENHI-PROJECT-15K14979, KAKENHI-PROJECT-14J07568, KAKENHI-PROJECT-16H02611
  • [Journal Article] Facile synthesis of C-terminal peptide thioacids under mild conditions from N-sulfanylethylanilide peptides2016

    • Author(s)
      Shimizu, T.; Miyajima, R.; Sato, K.; Sakamoto, K.; Naruse, N.; Kita, M.; Shigenaga, A.*; Otaka, A.*
    • Journal Title

      Tetrahedron

      Volume: 72 Issue: 7 Pages: 992-998

    • DOI

      10.1016/j.tet.2015.12.070

    • NAID

      120006493362

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K07858, KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-15K14979
  • [Journal Article] Formation of stable nanodiscs by bihelical apolipoprotein A-I mimetic peptide2016

    • Author(s)
      Kariyazono, H., Nadai, R., Miyajima, R., Takechi-Haraya, Y., Baba, T., Shigenaga, A., Okuhira, K., Otaka, A., and Saito, H.
    • Journal Title

      J. Peptide Sci.

      Volume: 22 Issue: 2 Pages: 116-122

    • DOI

      10.1002/psc.2847

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25293006, KAKENHI-PROJECT-16K08236
  • [Journal Article] Development of an anilide type scaffold for the thioester precursor N-sulfanylethylcoumarynyl amide.2016

    • Author(s)
      Eto, M.; Naruse, N.; Morimoto, K.; Yamaoka, K.; Sato, K.; Tsuji, K.; Inokuma, T.; Shigenaga, A.; Otaka, A.
    • Journal Title

      Org. Lett.

      Volume: 18 Issue: 17 Pages: 4416-4419

    • DOI

      10.1021/acs.orglett.6b02207

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-15K14979, KAKENHI-PROJECT-15K07858, KAKENHI-PROJECT-16K21077
  • [Journal Article] Preparation of peptide thioesters from naturally occurring sequences using reaction sequence consisting of regioselective S-cyanylation and hydrazinolysis2016

    • Author(s)
      Rin Miyajima, Yusuke Tsuda, Tsubasa Inokuma, Akira Shigenaga, Miki Imanishi, Shiro Futaki and Akira Otaka
    • Journal Title

      Biopolymers

      Volume: - Issue: 4 Pages: 531-546

    • DOI

      10.1002/bip.22757

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K14979, KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-15K07858
  • [Journal Article] 天然アミノ酸配列に適用可能な新規タンパク質チオエステル合成法の開発2016

    • Author(s)
      津田雄介、重永 章、佐藤浩平、中村太寛、北風圭介、猪熊 翼、伊藤孝司、大髙 章
    • Journal Title

      ケミカルバイオロジー

      Volume: 9 Pages: 7-10

    • NAID

      40021146446

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Journal Article] Enthalpy-driven interactions with sulfated glycosaminoglycans promote cell membrane penetration of arginine peptides2016

    • Author(s)
      Takechi-Haraya, Y., Nadai, R., Kimura, H., Nishitsuji, K., Uchimura, K., Sakai-Kato, K., Kawakami, K. Shigenaga, A., Kawakami, T., Otaka, A., Hojo, H., Sakashita, N., and Saito, H.
    • Journal Title

      BBA - Biomembranes

      Volume: 1858 Pages: 1339-1349

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25293006
  • [Journal Article] Chemical synthesis of proteins using N-sulfanylethylanilide peptides, based on N-S acyl transfer chemistry2015

    • Author(s)
      A. Otaka, K. Sato, A. Shigenaga
    • Journal Title

      Topics Current Chem

      Volume: in press Pages: 33-56

    • DOI

      10.1007/128_2014_586

    • ISBN
      9783319191881, 9783319191898
    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390026, KAKENHI-PROJECT-25670058
  • [Journal Article] Development of chemical methodology for preparation of peptide thioesters applicable to naturally occurring peptides using a sequential quadruple acyl transfer system2015

    • Author(s)
      Yusuke Tsuda, Akira Shigenaga, Masaya Denda, Kohei Sato, Keisuke Kitakaze, Takahiro Nakamura, Tsubasa Inokuma, Kouji Itou and Akira Otaka
    • Journal Title

      ChemistryOpen

      Volume: 4 Issue: 4 Pages: 448-452

    • DOI

      10.1002/open.201500086

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K14979, KAKENHI-PROJECT-15J09928, KAKENHI-PROJECT-26670269, KAKENHI-PROJECT-26293120
  • [Journal Article] Efficient one-pot synthesis of CXCL14 and its derivative using an N-sulfanylethylanilide peptide as a peptide thioester equivalent and their biological evaluation2015

    • Author(s)
      Kohei Tsuji, Kosuke Tanegashima, Kohei Sato, Ken Sakamoto, Akira Shigenaga, Tsubasa Inokuma, Takahiko Hara and Akira Otaka
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 23 Issue: 17 Pages: 5909-5914

    • DOI

      10.1016/j.bmc.2015.06.064

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K14979, KAKENHI-PROJECT-25860304
  • [Journal Article] Amyloidogenic Mutation Promotes Fibril Formation of the N-terminal Apolipoprotein A-I on Lipid Membranes.2015

    • Author(s)
      Mizuguchi, C., Ogata, F., Mikawa, S., Tsuji, K., Baba, T., Shigenaga, A., Shimanouchi, T., Okuhira, K., Otaka, A., and Saito, H.
    • Journal Title

      J. Biol. Chem.

      Volume: 290 Issue: 34 Pages: 20947-20959

    • DOI

      10.1074/jbc.m115.664227

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25293006
  • [Journal Article] Liquid-phase synthesis of bridged peptides using olefin metathesis of protected peptide with long aliphatic chain anchor2015

    • Author(s)
      K. Aihara, C. Komiya, A. Shigenaga, T. Inokuma, D. Takahashi and A. Otaka
    • Journal Title

      Organic Letters

      Volume: 17 Issue: 3 Pages: 696-699

    • DOI

      10.1021/ol503718j

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-14J07568, KAKENHI-PROJECT-24390026, KAKENHI-PROJECT-24590010, KAKENHI-PROJECT-25670058
  • [Journal Article] Design and synthesis of a hydrogen peroxide-responsive amino acid that induces peptide bond cleavage after exposure to hydrogen peroxide2015

    • Author(s)
      Kita, M.; Yamamoto, J.; Morisaki, T.; Komiya, C.; Inokuma, T.; Miyamoto, L.; Tsuchiya, K.; Shigenaga, A.*; Otaka, A.*
    • Journal Title

      Tetrahedron Lett.

      Volume: 56 Issue: 28 Pages: 4228-4231

    • DOI

      10.1016/j.tetlet.2015.05.060

    • NAID

      120006493359

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K07858
  • [Journal Article] The total chemical synthesis of the monoglycosylated GM2 ganglioside activator using a novel cysteine surrogate2015

    • Author(s)
      Kohei Sato, Keisuke Kitakaze, Takahiro Nakamura, Naoto Naruse, Keisuke Aihara, Akira Shigenaga, Tsubasa Inokuma, Daisuke Tsuji, Kouji Itou and Akira Otaka
    • Journal Title

      Chemical Communications

      Volume: 49 Issue: 49 Pages: 9946-9948

    • DOI

      10.1039/c5cc02967h

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K14979, KAKENHI-PROJECT-25460389, KAKENHI-PROJECT-26670269, KAKENHI-PROJECT-26293120
  • [Journal Article] Molecular complex composed of β-cyclodextrin-grafted chitosan and pH-sensitive amphipathic peptide for enhancing cellular cholesterol efflux under acidic pH.2015

    • Author(s)
      Takechi-Haraya, Y., Tanaka, K., Tsuji, K., Asami, Y., Izawa, H., Shigenaga, A., Otaka, A., Saito, H., and Kawakami, K.
    • Journal Title

      Bioconjugate Chem.

      Volume: 26 Issue: 3 Pages: 572-581

    • DOI

      10.1021/acs.bioconjchem.5b00037

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293006
  • [Journal Article] ペプチド・タンパク質を基盤とする創薬展開への化学基盤の開拓2014

    • Author(s)
      佐藤浩平、大高 章
    • Journal Title

      化学工業

      Volume: 6 Pages: 411-417

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25670058
  • [Journal Article] Development of a fluoride-responsive amide bond cleavage device that is potentially applicable to a traceable linker2014

    • Author(s)
      J. Yamamoto, N. Maeda, C. Komiya, T. Tanaka, M. Denda, K. Ebisuno, W. Nomura, H. Tamamura, Y. Sato, A. Yamauchi, A. Shigenaga, and A. Otaka
    • Journal Title

      Tetrahedron

      Volume: 70 Issue: 34 Pages: 5122-5127

    • DOI

      10.1016/j.tet.2014.05.110

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-13J07086, KAKENHI-PROJECT-23390026, KAKENHI-PROJECT-24390026, KAKENHI-PROJECT-24590010, KAKENHI-PUBLICLY-25107724, KAKENHI-PROJECT-25410171, KAKENHI-PROJECT-25670058, KAKENHI-PUBLICLY-26119703, KAKENHI-PROJECT-26462461
  • [Journal Article] タンパク性医薬品開発に向けたペプチド化学2014

    • Author(s)
      中村太寛、佐藤浩平、大高 章
    • Journal Title

      化学工業

      Volume: 65 Pages: 842-848

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24390026
  • [Journal Article] タンパク性医薬品開発に向けたペプチド化学2014

    • Author(s)
      中村太寛、佐藤浩平、大高 章
    • Journal Title

      化学工業

      Volume: 65 Pages: 849-856

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25670058
  • [Journal Article] ペプチド・タンパク質を基盤とする創薬展開への化学基盤の開拓2014

    • Author(s)
      佐藤浩平、大高 章
    • Journal Title

      化学工業

      Volume: 6 Pages: 411-417

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24390026
  • [Journal Article] 刺激応答型アミノ酸の開発と生命科学分野への展開2014

    • Author(s)
      重永 章、大高 章
    • Journal Title

      化学工業

      Volume: 65 Pages: 849-856

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25670058
  • [Journal Article] The Extreme N-terminal Region of Human Apolipoprotein A-I Has a Strong Propensity to Form Amyloid Fibrils2014

    • Author(s)
      Adachi, E., Kosaka, A., Tsuji, K., Mizuguchi, C., Kawashima, H., Shigenaga, A., Nagao, K., Akaji, K., Otaka, A., and Saito, H.
    • Journal Title

      FEBS Lett.

      Volume: 588 Issue: 3 Pages: 389-394

    • DOI

      10.1016/j.febslet.2013.11.031

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293006, KAKENHI-PROJECT-25670014, KAKENHI-PROJECT-25850070
  • [Journal Article] 刺激応答型アミノ酸の開発と生命科学分野への展開2014

    • Author(s)
      重永 章、大高 章
    • Journal Title

      化学工業

      Volume: 65 Pages: 849-856

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24390026
  • [Journal Article] Examination of native chemical ligation using peptidyl prolyl thioester2014

    • Author(s)
      T. Nakamura, A. Shigenaga, K. Sato, Y. Tsuda, K. Sakamoto, and A. Otaka.
    • Journal Title

      Chem. Commun.

      Volume: 50 Issue: 1 Pages: 58-60

    • DOI

      10.1039/c3cc47228k

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390026, KAKENHI-PUBLICLY-24102521, KAKENHI-PROJECT-24390026, KAKENHI-PROJECT-24590010, KAKENHI-PUBLICLY-25107724, KAKENHI-PROJECT-25670058
  • [Journal Article] Development of a traceable linker containing a thiol-responsive amino acid for the enrichment and selective labelling of target proteins2014

    • Author(s)
      J. Yamamoto, M. Denda, N. Maeda, M. Kita, C. Komiya, T. Tanaka, W. Nomura, H. Tamamura, Y. Sato, A. Yamauchi, A. Shigenaga, and A. Otaka
    • Journal Title

      Org. Biomol. Chem.

      Volume: 12 Issue: 23 Pages: 3821-3826

    • DOI

      10.1039/c4ob00622d

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-13J07086, KAKENHI-PROJECT-23390026, KAKENHI-PROJECT-24390026, KAKENHI-PROJECT-24590010, KAKENHI-PUBLICLY-25107724, KAKENHI-PROJECT-25410171, KAKENHI-PROJECT-25670058, KAKENHI-PUBLICLY-26119703, KAKENHI-PROJECT-26462461
  • [Journal Article] Development of caged non-hydrolyzable phosphoamino acids and application to photo-control of binding affinity of phosphopeptide mimetic to phosphopeptide-recognizing protein2014

    • Author(s)
      K. Ebisuno, M. Denda, K. Ogura, T. Inokuma, A. Shigenaga, and A. Otaka
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 22 Issue: 11 Pages: 2984-2991

    • DOI

      10.1016/j.bmc.2014.04.002

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-13J07086, KAKENHI-PROJECT-24390026, KAKENHI-PROJECT-24590010, KAKENHI-PUBLICLY-25107724, KAKENHI-PROJECT-25670058
  • [Journal Article] Chemical synthesis of biologically active monoglycosylated GM2-activator protein analog using N-sulfanylethylanilide peptide2013

    • Author(s)
      K. Sato, A. Shigenaga, K. Kitakaze, K. Sakamoto, D. Tsuji, K. Itoh, A. Otaka
    • Journal Title

      Angew. Chem. Int. Ed

      Volume: vol.52 Issue: 30 Pages: 7855-7859

    • DOI

      10.1002/anie.201303390

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390026, KAKENHI-PROJECT-23390140, KAKENHI-PROJECT-23659055, KAKENHI-PUBLICLY-24102521, KAKENHI-PROJECT-24390026, KAKENHI-PROJECT-24590010, KAKENHI-PROJECT-24659262, KAKENHI-PUBLICLY-25107724, KAKENHI-PUBLICLY-25110722, KAKENHI-PROJECT-25460389, KAKENHI-PROJECT-25670058
  • [Journal Article] CXCL14 is a natural inhibitor of the CXCL12-CXCR4 signaling axis2013

    • Author(s)
      K. Tanegashima, K. Suzukia, Y. Nakayama, K. Tsuji, A. Shigenaga, A. Otaka, and T. tiara
    • Journal Title

      FEBS Letters

      Volume: 587 Issue: 12 Pages: 1731-1735

    • DOI

      10.1016/j.febslet.2013.04.046

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J08863, KAKENHI-PROJECT-22791043, KAKENHI-PROJECT-23390256, KAKENHI-PROJECT-23659055, KAKENHI-PROJECT-23659481, KAKENHI-PROJECT-25860304, KAKENHI-PUBLICLY-23126528
  • [Journal Article] Synthetic Procedure for N-Fmoc Amino Acyl-N-Sulfanylethylaniline Linker as Crypto-Peptide Thioester Precursor with Application to Native Chemical Ligation2012

    • Author(s)
      Sakamoto K, et al.
    • Journal Title

      The Journal of Organic Chemistry

      Volume: 77 Issue: 16 Pages: 6948-6958

    • DOI

      10.1021/jo3011107

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J08863, KAKENHI-PROJECT-23390026, KAKENHI-PROJECT-23659055, KAKENHI-PROJECT-24390026, KAKENHI-PROJECT-24590010, KAKENHI-PUBLICLY-23107523, KAKENHI-PUBLICLY-24102521
  • [Journal Article] One-pot/sequential native chemical ligation using N-sulfanylethylanilide peptide2012

    • Author(s)
      Otaka A
    • Journal Title

      Chemical Record

      Volume: 12 Issue: 5 Pages: 479-490

    • DOI

      10.1002/tcr.201200007

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390026, KAKENHI-PROJECT-23659055, KAKENHI-PROJECT-24390026, KAKENHI-PROJECT-24590010, KAKENHI-PUBLICLY-23107523, KAKENHI-PUBLICLY-24102521
  • [Journal Article] N-Sulfanyl-ethylanilide peptide : a peptide thioester equivalent which can directly participate in native chemical ligation2012

    • Author(s)
      Sato, K.; Tsuda, S.; Sakamoto, K.; Shigenaga, A.; Otaka, A
    • Journal Title

      Peptide Science 2011

      Pages: 13-14

    • NAID

      10030203930

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390031
  • [Journal Article] Double-kinetically controlled proline ligation2012

    • Author(s)
      Ding, H.; Sato, K.; Morishita, K.; Shigenaga, A.; Otaka, A
    • Journal Title

      Peptide Science 2011

      Pages: 133-134

    • NAID

      10030204136

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390031
  • [Journal Article] Caged ceramide which releases parent ceramide after UV-induced amide bond cleavage followed by intramolecular O-N acyl transfer2012

    • Author(s)
      Shigenaga, A.; Hirakawa, H.; Yamamoto, J.; Ogura, K.; Denda, M.; Yamaguchi, K.; Otaka, A
    • Journal Title

      Peptide Science 2011

      Pages: 385-386

    • NAID

      10030204614

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390031
  • [Journal Article] Fmoc-based solid phase synthesis of adenylylated peptides using diester-type adenylylated amino acid derivatives2012

    • Author(s)
      Ogura, K.; Shigenaga, A.; Ebisuno, K.; Hirakawa, H.; Otaka, A
    • Journal Title

      Tetrahedron Lett

      Volume: (in press) Issue: 27 Pages: 3429-3432

    • DOI

      10.1016/j.tetlet.2012.04.063

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390031, KAKENHI-PROJECT-22790012, KAKENHI-PROJECT-23390026, KAKENHI-PROJECT-23659055, KAKENHI-PROJECT-24390026, KAKENHI-PUBLICLY-23107523, KAKENHI-PUBLICLY-24102521
  • [Journal Article] Development of a reduction-responsive amino acid that induces peptide bond cleavage in hypoxic cells2012

    • Author(s)
      Shigenaga, A., et al.
    • Journal Title

      ChemBioChem

      Volume: 13 Issue: 7 Pages: 968-971

    • DOI

      10.1002/cbic.201200141

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J08406, KAKENHI-PROJECT-21390031, KAKENHI-PROJECT-22790012, KAKENHI-PROJECT-23390026, KAKENHI-PROJECT-23659055, KAKENHI-PROJECT-24390026, KAKENHI-PUBLICLY-24102521
  • [Journal Article] Development of Organic and Bio-organic Methodologies for the Synthesis of Proteins2012

    • Author(s)
      大高 章
    • Journal Title

      Journal of Synthetic Organic Chemistry, Japan

      Volume: 70 Issue: 10 Pages: 1054-1068

    • DOI

      10.5059/yukigoseikyokaishi.70.1054

    • NAID

      10031124010

    • ISSN
      0037-9980, 1883-6526
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390026, KAKENHI-PROJECT-23659055, KAKENHI-PROJECT-24390026, KAKENHI-PUBLICLY-24102521
  • [Journal Article] Development of UV-responsive catch-and-release system of a cysteine protease model peptide2011

    • Author(s)
      Shigenaga, A.; Morishita, K.; Yamaguchi, K.; Ding, H.; Ebisuno, K.; Sato, K.; Yamamoto, J.; Akaji, K.; Otaka, A
    • Journal Title

      Tetrahedron

      Volume: 67 Issue: 46 Pages: 8879-8886

    • DOI

      10.1016/j.tet.2011.09.062

    • NAID

      120006493356

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390031, KAKENHI-PROJECT-22790012, KAKENHI-PUBLICLY-23107523, KAKENHI-PROJECT-23390026, KAKENHI-PROJECT-23659055
  • [Journal Article] Synthesis of CXCL14 and its derivatives utilizing C to N or N to C directive sequential NCL protocol2011

    • Author(s)
      Tsuji, K.; Sumikawa, Y.; Tanegashima, K.; Shigenaga, A.; Hara, T.; Otaka, A
    • Journal Title

      Biopolymers

      Volume: 96 Pages: 447-447

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659055
  • [Journal Article] Synthesis of nonhydrolyzable AMPylated amino acid analogues for uncovering the physiological role of AMPylation2011

    • Author(s)
      Ogura, K.; Hirakawa, H.; Shigenaga, A.; Otaka, A
    • Journal Title

      Peptide Science 2010

      Pages: 205-205

    • NAID

      10028237863

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390031
  • [Journal Article] N-Sulfanylethylanilide peptide as a crypto-thioester peptide2011

    • Author(s)
      Sato, K.; Shigenaga, A.; Tsuji, K.; Tsuda, S.; Sumikawa, Y.; Sakamoto, K.; Otaka, A
    • Journal Title

      ChemBioChem

      Volume: 12 Issue: 12 Pages: 1840-1844

    • DOI

      10.1002/cbic.201100241

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390031, KAKENHI-PROJECT-22790012, KAKENHI-PUBLICLY-23107523, KAKENHI-PROJECT-23390026, KAKENHI-PROJECT-23659055
  • [Journal Article] Native chemical ligation using N-peptidyl anilide as crypto-thioester2011

    • Author(s)
      Sato, K.; Tsuda, S.; Maeda, N.; Denda, M.; Shigenaga, A.; Otaka, A
    • Journal Title

      Peptide Science 2010

      Pages: 203-203

    • NAID

      10028237853

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390031
  • [Journal Article] Development of stimulus responsive thiol releasing system for controlling activity of cysteine protease2011

    • Author(s)
      Morishita, K.; Yamaguchi, K.; Ding, H.; Shigenaga, A.; Akaji, K.; Otaka, A
    • Journal Title

      Peptide Science 2010

      Pages: 290-290

    • NAID

      10028238228

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390031
  • [Journal Article] Development of amide bond cleavage device with application to chemical biology use2011

    • Author(s)
      Otaka, A.; Shigenaga, A
    • Journal Title

      Peptide Science 2010

      Pages: 49-49

    • NAID

      10028237182

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390031
  • [Journal Article] Design and Synthesis of Traceable Linker for Efficient Enrichment and Specific Labeling of Target Proteins2011

    • Author(s)
      Yamamoto, J.; Tanaka, T.; Denda, M.; Shigenaga, A.; Nomura, W.; Tamamura, H.; Otaka, A
    • Journal Title

      Biopolymers

      Volume: 96 Pages: 492-492

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659055
  • [Journal Article] Dual kinetically-controlled native chemical ligation using a combi-nation of sulfanylproline and sulfanyl-ethylanilide peptide2011

    • Author(s)
      Ding, H.; Shigenaga, A.; Sato, K.; Morishita, K.; Otaka, A
    • Journal Title

      Org. Lett

      Volume: 13 Issue: 20 Pages: 5588-5591

    • DOI

      10.1021/ol202316v

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390031, KAKENHI-PROJECT-22790012, KAKENHI-PUBLICLY-23107523, KAKENHI-PROJECT-23659055
  • [Journal Article] N-Sulfanylethyl-anilide derivative as a peptide thioester equivalent2011

    • Author(s)
      Sato, K.; Tsuda, S.; Tsuji, K.; Sakamoto, K.; Shigenaga, A.; Otaka, A
    • Journal Title

      Proceedings of the Twenty-Second American Peptide Symposium

      Pages: 72-73

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390031
  • [Journal Article] N-sulfanylethylanilide derivative as a peptide thioester equivalent2011

    • Author(s)
      Sato, K.; Tsuda, S.; Tsuji, K.; Sakamoto, K.; Shigenaga, A.; Otaka, A
    • Journal Title

      Biopolymers

      Volume: 96 Pages: 445-445

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659055
  • [Journal Article] Application of N-C-or C-N-directed sequential native chemical ligation to the preparation of CXCL14 analogs and their biological evaluation2011

    • Author(s)
      Tsuji, K.; Shigenaga, A.; Sumikawa, Y.; Tanegashima, K.; Sato, K.; Aihara, K.; Hara, T.; Otaka, A
    • Journal Title

      Bioorg. Med. Chem

      Volume: 19 Issue: 13 Pages: 4014-4020

    • DOI

      10.1016/j.bmc.2011.05.018

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390031, KAKENHI-PROJECT-22790012, KAKENHI-PUBLICLY-23107523, KAKENHI-PROJECT-23390026, KAKENHI-PROJECT-23659055, KAKENHI-PROJECT-23659481
  • [Journal Article] Enantioselective synthesis of stimulus-responsive amino acid via pyrrolidinyl tetrazole catalyzed asymmetricα-amination of aldehyde2011

    • Author(s)
      Shigenaga, A.; Yamamoto, J.; Nishioka, N.; Denda, M.; Otaka, A
    • Journal Title

      Peptide Science 2010

      Pages: 202-202

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390031
  • [Journal Article] Synthesis of CXCL14 and its derivatives utilizing C to N or N to C directive sequential NCL protocol2011

    • Author(s)
      Tsuji, K.; Sumikawa, Y.; Tanegashima, K.; Shigenaga, A.; Hara, T.; Otaka, A
    • Journal Title

      Proceedings of the Twenty-Second American Peptide Symposium

      Pages: 74-75

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390031
  • [Journal Article] Design and synthesis of caged ceramide : UV-responsive ceramide releasing system based on UV-induced amide bond cleavage followed by O-N acyl transfer2011

    • Author(s)
      Shigenaga, A.; Hirakawa, H.; Yamamoto, J.; Ogura, K.; Denda, M.; Yamaguchi, K.; Tsuji, D.; Itoh, K.; Otaka, A
    • Journal Title

      Tetrahedron

      Volume: 67 Issue: 22 Pages: 3984-3990

    • DOI

      10.1016/j.tet.2011.04.048

    • NAID

      120006493357

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390031, KAKENHI-PROJECT-22790012, KAKENHI-PUBLICLY-23107523, KAKENHI-PROJECT-23390026
  • [Journal Article] Design and synthesis of caged ceramide: UV-responsive ceramide releasing system based on UV-induced amide bond cleavage followed by O-N acyl transfer2011

    • Author(s)
      Shigenaga, A.; Hirakawa, H.; Yamamoto, J.; Ogura, K.; Denda, M.; Yamaguchi, K.; Tsuji, D.; Itoh, K.; Otaka, A
    • Journal Title

      Tetrahedron

      Volume: 67 Pages: 3984-3990

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659055
  • [Journal Article] Synthesis and biological evaluation of CXCL14 and its derivatives2011

    • Author(s)
      Tsuji, K.; Sumikawa, Y.; Tanegashima, K.; Shigenaga, A.; Hara, T.; Otaka, A
    • Journal Title

      Peptide Science 2010

      Pages: 182-182

    • NAID

      10028237759

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390031
  • [Journal Article] Development of recapturable cleavable linker for efficient enrichment and specific labeling of target proteins2011

    • Author(s)
      Yamamoto, J.; Maeda, N.; Denda, M.; Shigenaga, A.; Otaka, A
    • Journal Title

      Peptide Science 2010

      Pages: 232-232

    • NAID

      10028237977

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390031
  • [Journal Article] Sequential native chemical ligation utilizing peptide thioacids derived from newly developed Fmoc-based synthetic method2010

    • Author(s)
      Shigenaga, A.; Sumikawa, Y.; Tsuda, S.; Sato, K.; Otaka, A
    • Journal Title

      Tetrahedron

      Volume: 66 Issue: 18 Pages: 3290-3296

    • DOI

      10.1016/j.tet.2010.03.016

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390031
  • [Journal Article] Proline cis/ trans-Isomerase Pin1 Regulates Peroxisome Proliferator-activated Receptor gamma Activity through the Direct Binding to the Activation Function-1 Domain2010

    • Author(s)
      Fujimoto, Y.; Shiraki, T.; Horiuchi, Y.; Waku, T.; Shigenaga, A.; Otaka, A.; Ikura, T.; Igarashi, K.; Aimoto, S.; Tate, S.; Morikawa, K
    • Journal Title

      J. Biol. Chem

      Volume: 285 Issue: 5 Pages: 3126-3132

    • DOI

      10.1074/jbc.m109.055095

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390031
  • [Journal Article] Recent Progress in the Synthetic Methodologies of Peptide Thioesters2010

    • Author(s)
      Shigenaga, A.; Sato, K.; Otaka, A
    • Journal Title

      Journal of Synthetic Organic Chemistry, Japan

      Volume: 68 Issue: 9 Pages: 911-919

    • DOI

      10.5059/yukigoseikyokaishi.68.911

    • NAID

      10026870593

    • ISSN
      0037-9980, 1883-6526
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390031
  • [Journal Article] Development of thiol-responsive amide bond cleavage device and its application for peptide nucleic acid-based DNA releasing system2010

    • Author(s)
      Shigenaga, A.; Yamamoto, J.; Hirakawa, H.; Ogura, K.; Maeda, N.; Morishita, K.; Otaka, A
    • Journal Title

      Tetrahedron Lett

      Volume: 51 Issue: 18 Pages: 2525-2528

    • DOI

      10.1016/j.tetlet.2010.03.006

    • NAID

      120006493352

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390031
  • [Journal Article] Enantioselective synthesis of stimulus-responsive amino acid via asymmetricα-amination of aldehyde2010

    • Author(s)
      Shigenaga, A.; Yamamoto, J.; Nishioka, N.; Otaka, A
    • Journal Title

      Tetrahedron

      Volume: 66 Issue: 37 Pages: 7367-7372

    • DOI

      10.1016/j.tet.2010.07.033

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390031, KAKENHI-PROJECT-22790012
  • [Journal Article] Development of amide bond cleavage device with application to chemical biology use2010

    • Author(s)
      Otaka, A.
    • Journal Title

      Peptide Science 2010

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390031
  • [Journal Article] A structure-activity relationship study elucidating the mechanism of sequence-specific collagen recognition by the chaperone HSP472010

    • Author(s)
      Nishikawa, Y.; Takahara, Y.; Asada, S.; Shigenaga, A.; Otaka, A.; Kitagawa, K.; Koide, T
    • Journal Title

      Bioorg. Med. Chem

      Volume: 18 Issue: 11 Pages: 3767-3775

    • DOI

      10.1016/j.bmc.2010.04.054

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390031
  • [Journal Article] N-> S Acyl-Transfer-Mediated Synthesis of Peptide Thioesters Using Anilide Derivatives2009

    • Author(s)
      Tsuda, S.; Shigenaga, A.; Bando, K.; Otaka, A
    • Journal Title

      Org. Lett

      Volume: 11 Issue: 4 Pages: 823-826

    • DOI

      10.1021/ol8028093

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390031
  • [Journal Article] Synthesis of Fluoroalkene Dipeptide Isosteres by an Intramolecular Redox Reaction Utilizing N-Heteorocyclic Carbenes(NHCs)2009

    • Author(s)
      Yamaki, Y.; Shigenaga, A.; Tomita, K.; Narumi, T.; Fujii, N.; Otaka, A
    • Journal Title

      J. Org. Chem

      Volume: 74 Issue: 9 Pages: 3272-3277

    • DOI

      10.1021/jo900134k

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390031
  • [Journal Article] Synthesis of Amide-type Fluoroalkene Dipeptide Isosteres by Intramolecular Redox Reaction2009

    • Author(s)
      Y. Yamaki, A. Shigenaga, J. Li, Y. Shimohigashi, A. Otaka
    • Journal Title

      J. Org. Chem 74

      Pages: 3278-3285

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Journal Article] N-S acyl-transfer-mediated synthesis of peptide thioesters using anilide derivatives2009

    • Author(s)
      S. Tsuda, A. Shigenaga, K. Bandoh, A. Otaka
    • Journal Title

      Org. Lett 11

      Pages: 823-826

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Journal Article] Synthesis of Fluoroalkene Dipeptide Isosteres by Intramolecular Redox Reaction Utilizing N-Heteorocyclic Carbenes(NHCs)2009

    • Author(s)
      Y. Yamaki, A. Shigenaga, K. Tomita, T. Narumi, N. Fujii, A. Otaka
    • Journal Title

      J. Org. Chew 74

      Pages: 3272-3277

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Journal Article] FRET-based assay of the processing reaction kinetics of stimulus-responsive peptides : influence of amino acid sequence on reaction kinetics2009

    • Author(s)
      A. Shigenaga, J. Yamamoto, H. Hirakawa, K. Yamaguchi, A. Otaka
    • Journal Title

      Tetrahedron 65

      Pages: 2212-2216

    • NAID

      120006493353

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Journal Article] Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 12009

    • Author(s)
      Yun, S. M.; Moulaei, T.; Lim, D.; Bang, J. K.; Park, J. E.; Shenoy, S. R.; Liu, F.; Kang, Y. H.; Liao, C. Z.; Soung, N. K.; Lee, S.; Yoon, D. Y.; Lim, Y.; Lee, D. H.; Otaka, A.; Appella, E.; McMahon, J. B.; Nicklaus, M. C.; Burke, T. R.; Yaffe, M. B.; Wlodawer, A.; Lee, K. S.
    • Journal Title

      Nature Structural & Molecular Biology

      Volume: 16 Issue: 8 Pages: 876-882

    • DOI

      10.1038/nsmb.1628

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390031
  • [Journal Article] Electrostatically constrained a-helical peptide inhibits replication of HIV-1 resistant to Enfuvirtide2009

    • Author(s)
      H. Nishikawa, S. Nakamura, E. Kodama, S. Ito, K. Kajiwara, K. Izumi, Y. Sakagami, S. Oishi, T. Ohkubo, Y. Kobayashi, A. Otaka, N. Fujii, and M. Matsuoka
    • Journal Title

      Int. J. Cell. Biol 41

      Pages: 891-899

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Journal Article] Synthesis of Amide-Type Fluoroalkene Dipeptide Isosteres by an Intramolecular Redox Reaction2009

    • Author(s)
      Yamaki, Y.; Shigenaga, A.; Li, J. L.; Shimohigashi, Y.; Otaka, A
    • Journal Title

      J. Org. Chem

      Volume: 74 Issue: 9 Pages: 3278-3285

    • DOI

      10.1021/jo900135t

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390031
  • [Journal Article] FRET-based assay of the processing reaction kinetics of stimulus-responsive peptides : influence of amino acid sequence on reaction kinetics2009

    • Author(s)
      Shigenaga, A.; Yamamoto, J.; Hirakawa, H.; Yamaguchi, K.; Otaka, A
    • Journal Title

      Tetrahedron

      Volume: 65 Issue: 10 Pages: 2212-2216

    • DOI

      10.1016/j.tet.2009.01.013

    • NAID

      120006493353

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390031
  • [Journal Article] Heptad Repeat-Derived Peptides Block Protease-Mediated Direct Entry from the Cell Surface of Severe Acute Respiratory Syndrome Coronavirus but Not Entry via the Endosomal Pathway2008

    • Author(s)
      M. Ujike, H. Nishikawa, A. Otaka, N. Yamamoto, N. Yamamoto, M. Matsuoka, E. Kodama, N. Fujii, and F. Taguchi
    • Journal Title

      J. Virology 82

      Pages: 588-592

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Journal Article] Identification of minimal sequence for HIV-1 fusion inhibitors2008

    • Author(s)
      H. Nishikawa, S. Oishi, M. Fujita, K. Watanabe, R. Tokiwa, H. Ohno, E. Kodama, K. Izumi, K. Kajiwara, T. Naitoh, M. Matsuoka, A. Otaka, and N. Fujii
    • Journal Title

      Bioorg. Med. Chem 20

      Pages: 9184-9187

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Journal Article] Synthesis of a nucleocytoplasmic shuttle peptide possessing a stimulus-responsive amino acid2008

    • Author(s)
      A. Shigenaga, D. Tsuji, N. Nishioka, S. Tsuda, K. Itoh and A. Otaka
    • Journal Title

      Chemical Biology 1

      Pages: 7-10

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Journal Article] Synthesis of (Z)-alkene-containing cis-proline dipeptide mimetics using amarium(II) diiodide (SmI_2)-mediated reductive alkylation reaction2007

    • Author(s)
      Y. Sasaki, A. Shigenaga, N. Fujii and A. Otaka
    • Journal Title

      Tetrahedron 63

      Pages: 2000-2008

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Journal Article] Synthesis of a stimulus-responsive processing device and its application to a nucleocytoplasmic shuttle peptide2007

    • Author(s)
      A. Shigenaga, D. Tsuji, N. Nishioka, S. Tsuda, K. Itoh and A. Otaka
    • Journal Title

      Chem Bio Chem 8

      Pages: 1929-1931

    • NAID

      120006493351

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Journal Article] Development of copper-mediated allylation of γ-activated-α,113-unsaturated lactam toward peptide mimetic synthesis2007

    • Author(s)
      Y. Sasaki, K. Yamaguchi, T. Tsuji, A. Shigenaga, N. Fujii and A. Otaka
    • Journal Title

      Tetrahedron Lett 48

      Pages: 3221-3224

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Journal Article] α2 Isoform-specific activation of 5'adenosine monophosphate-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-β-D-ribonucleoside at a physiological level activates glucose transport and increases glucose transporter 4 in mouse skeletal muscle2006

    • Author(s)
      M. Nakano, T. Hamada, T. Hayashi, S. Yonemitsu, L. Miyamoto, T. Toyoda, S. Tanaka, H. Masuzaki, K. Ebihara, Y. Ogawa, K. Hosoda, G. Inoue, Y. Yoshimasa, A. Otaka, T. Fushiki, and K. Nakao
    • Journal Title

      Metab. Clinic. Experiment 55

      Pages: 300-308

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Journal Article] Stereoselective Synthesis of(Z)-Alkene-Containing Proline Dipeptide Mimetics2006

    • Author(s)
      Y. Sasaki, A. Niida, T. Tsuji, A. Shigenaga, N. Fujii, and A. Otaka
    • Journal Title

      J. Org. Chem 71

      Pages: 4969-4979

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Journal Article] Synthesis of(Z)-Alkene and(E)-Fluoroalkene-Containing Diketopiperazine Mimetics Utilizing Oraganocopper-Mediated Reduction-Alkylation and Diastereoseleetivity Examination Using DFT Calculations2006

    • Author(s)
      A. Niida, M. Mizumoto, T. Narumi, E. Inokuehi, S. Oishi, H. Ohno, A. Otaka, K. Kitaura, and N. Fujii
    • Journal Title

      J. Org. Chem 71

      Pages: 4118-4129

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Journal Article] A novel one-pot reaction involving organocopper-mediated reduction/transmetalation/asymmetric alkylation, leading to the diastereoselective synthesis of functionalized (Z)-fluoroalkene dipeptide isosteres2006

    • Author(s)
      T. Narumi, A. Niida, K. Tomita, S. Oishi, A. Otaka, H. Ohno and N. Fujii
    • Journal Title

      Chem. Commun 45

      Pages: 4720-4722

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Journal Article] Stereoselective Synthesis of 3,6-Disubstituted-3,6-dihydropyridin-2-ones as Potential Diketopiperazine Mimetics Using Organocopper-Mediated anti-SN2'Reactions and Their Use in the Preparation of Low-Molecule CXCR4 Antagonists2006

    • Author(s)
      Niida, H. Tanigaki, E. Inokuchi, Y. Sasaki, S. Oishi, H. Ohno, H. Tamamura, Z. Wang, S. C. Peiper, K. Kitaura, A. Otaka, and N. Fujii
    • Journal Title

      A. J. Org. Chem 71

      Pages: 3942-3951

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Journal Article] Unequivocal Synthesis of (Z)-Alkene and (E)-Fluoroalkene Dipeptide Isosters to Probe Structural Requirements of Peptide Transporter PEPTI2006

    • Author(s)
      A. Niida, K, Tomita, M. Mizuinoto, H. Tanigaki, T. Terada, S. Oishi, A. Otaka, K. Inui, and N. Fujii
    • Journal Title

      Org. Lett 8

      Pages: 613-616

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Journal Article] Specific recognition of the collagen triple helix by chaperone HSP47. II. The HSP47-binding structural motif in collagens and related proteins2006

    • Author(s)
      T. Koide, Y. Nishikawa, S. Asada, C. M. Yamazaki, Y. Takahara, D. L. Homma, A. Otaka, K. Ohtani, N. Wakamiya, K. Nagata, and K. Kitagawa
    • Journal Title

      J. Biol. Chem 281

      Pages: 11177-11185

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Journal Article] Cysteine-derived S-Protected Oxazolidinones : Potential Chemical. Devices for the Preparation of Peptide Thioesters2006

    • Author(s)
      Y. Ohta, S. Itch, A. Shigenaga, S. Shintaku, N. Fujii, and A. Otaka
    • Journal Title

      Org. Lett 8

      Pages: 467-470

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Journal Article] Sml_2-Mediated Reduction of γ,γ-Difluoro-α,β-enoates with Application to the Synthesis of Functionalized(Z)-Fluoroalkene-Type Dipeptide Isosteres.2004

    • Author(s)
      Akira Otaka et al.
    • Journal Title

      J.Org.Chem. 69

      Pages: 1634-1645

    • Data Source
      KAKENHI-PROJECT-15659026
  • [Journal Article] Facile Synthesis of Membrane-embedded Peptides Utilizing Lipid Bilayer-assisted Chemical Ligation.2004

    • Author(s)
      A.Otaka
    • Journal Title

      Chem. Commun.

      Pages: 1722-1723

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390037
  • [Journal Article] SmI2-mediated Reduction of γ,γ-Difluoro-_α,β-enoates and Its Application to the Synthesis of (Z)-Fluoroalkene-type Dipeptide Isosteres2004

    • Author(s)
      A.Otaka, J.Watanabe, N.Fujii, et al.
    • Journal Title

      J.Org.Chem. 69

      Pages: 1634-1645

    • Data Source
      KAKENHI-PROJECT-14207099
  • [Journal Article] Facile synthesis of membrane-embedded peptides utilizing lipid bilayer-assisted chemical ligation.2004

    • Author(s)
      Akira Otaka et al.
    • Journal Title

      Chem.Commun. 2004

      Pages: 1722-1723

    • Data Source
      KAKENHI-PROJECT-15659026
  • [Journal Article] Facile Synthesis of Membrane-embedded Peptides Utilizing Lipid Bilayer-assisted Chemical Ligation.2004

    • Author(s)
      A.Otaka, S.Ueda, N.Fujii, et al.
    • Journal Title

      Chem.Commun. 7

      Pages: 1722-1723

    • Data Source
      KAKENHI-PROJECT-14207099
  • [Journal Article] Facile Synthesis of Membrane-embedded Peptides Utilizing Lipid Bilayer-assisted Chemical Ligation.2004

    • Author(s)
      A.Otaka, et al.
    • Journal Title

      Chem.Commun. 7(15)

      Pages: 1722-1723

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14207099
  • [Journal Article] Facile synthesis of membrane-embedded peptides utilizing lipid bilayer-assisted chemical ligation.2004

    • Author(s)
      Akira Otaka et al.
    • Journal Title

      Chem.Commun. 2004

      Pages: 1722-1723

    • Data Source
      KAKENHI-PROJECT-15390037
  • [Journal Article] Synthesis of fluorine-containing Bioisosteres corresponding to phosphoamino acids and dipeptide units.2004

    • Author(s)
      Akira Otaka et al.
    • Journal Title

      Biopolymers 76

      Pages: 140-149

    • Data Source
      KAKENHI-PROJECT-15659026
  • [Journal Article] Synthesis of Fluorine-Containing Bioisosteres Corresponding to Phosphoamino Acids and Dipeptide Units2004

    • Author(s)
      A.Otaka, E.Mitsuyama, N.Fujii, et al.
    • Journal Title

      Biopolymers 76

      Pages: 140-149

    • Data Source
      KAKENHI-PROJECT-14207099
  • [Journal Article] Synthesis of fluorine-containing Bioisosteres corresponding to phosphoamino acids and dipeptide units.2004

    • Author(s)
      Akira Otaka et al.
    • Journal Title

      Biopolymers 76

      Pages: 140-149

    • Data Source
      KAKENHI-PROJECT-15390037
  • [Journal Article] SmI_2-Mediated Reduction of γ,γ-Difluoro-α,β-enoates with Application to the Synthesis of Functionalized (Z)-Fluoroalkene-Type Dipeptide Isosteres.2004

    • Author(s)
      A.Otaka
    • Journal Title

      J. Org. Chem. 69

      Pages: 1634-1645

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390037
  • [Journal Article] SmI_2-Mediated Reduction of γ,γ-Difluoro-α,β-enoates with Application to the Synthesis of Functionalized(Z)-Fluoroalkene-Type Dipeptide Isosteres.2004

    • Author(s)
      Akira Otaka et al.
    • Journal Title

      J.Org.Chem. 69

      Pages: 1634-1645

    • Data Source
      KAKENHI-PROJECT-15390037
  • [Journal Article] Facile Synthesis of Membrane-embedded Peptides Utilizing Lipid Bilayer-assisted Chemical Ligation.2004

    • Author(s)
      A.Otaka, et al.
    • Journal Title

      Chem.Commun. 7

      Pages: 1722-1723

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14207099
  • [Journal Article] Facile Synthesis of Membrane-embedded Peptides Utilizing Lipid Bilayer-assisted Chemical Ligation.2004

    • Author(s)
      A.Otaka
    • Journal Title

      Chem.Commun.

      Pages: 1722-1723

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390037
  • [Journal Article] SmI_2-Mediated Reduction of γ,γ-Difluoro-α,β-enoates with Application to the Synthesis of Functionalized (Z)-Fluoroalkene-Type Dipeptide Isosteres.2004

    • Author(s)
      A.Otaka
    • Journal Title

      J.Org.Chem. 69

      Pages: 1634-1645

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390037
  • [Journal Article] Synthesis of Fluorine-containing Bioisosteres Corresponding to Phosphoamino Acids and Dipeptide Units.2004

    • Author(s)
      A.Otaka
    • Journal Title

      Biopolymers 76

      Pages: 140-149

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390037
  • [Journal Article] Application of Samarium Diiodide (SmI_2)-induced Reduction of γ-Acetoxy-α,β-enoates with α-Specific Kinetic Electrophilic Trapping for the Synthesis of Amino Acid Derivatives.2003

    • Author(s)
      A.Otaka
    • Journal Title

      Chem.Commun.

      Pages: 1834-1835

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390037
  • [Journal Article] Application of Samarium Diiodide (SmI_2)-induced Reduction of γ-Acetoxy-α,β-enoates with α-Specific Kinetic Electrophilic Trapping for the Synthesis of Amino Acid Derivatives2003

    • Author(s)
      A.Otaka
    • Journal Title

      Chem. Commun.

      Pages: 1834-1835

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390037
  • [Presentation] 主鎖アミド保護基を活用したLossen転位反応による 合成後期ペプチドα位ヘテロ化法の開発2024

    • Author(s)
      林 隼矢, 小林 大志朗, 傳田 将也, 大髙 章
    • Organizer
      日本薬学会第144年会
    • Data Source
      KAKENHI-PROJECT-23K18187
  • [Presentation] EP4受容体の細胞内第3ループ領域に相互作用する因子の探索2024

    • Author(s)
      東山晃子、大西朗人、柳川瞬矢、清良尚史、John W. Regan、大川内健人、傳田将也、福島圭穣、西野耕平、大髙章、小迫英尊、藤野裕道
    • Organizer
      日本薬学会第144年会(横浜)
    • Data Source
      KAKENHI-PROJECT-23K06149
  • [Presentation] 保護システインスルホキシドを用いたワンポット連続ジスルフィド形成 によるインスリンの合成研究2023

    • Author(s)
      日高 功太, 小林 大志朗, 林 隼矢, 大川内 健人, 傳田 将也, 大髙 章
    • Organizer
      創薬懇話会2023 湯河原
    • Data Source
      KAKENHI-PROJECT-23K27300
  • [Presentation] Side reaction-inspired peptide and protein chemistry2023

    • Author(s)
      Akira Otaka
    • Organizer
      The 60th Japanese Peptide symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K27300
  • [Presentation] PREPARATION METHODOLOGY OF N-GLYOXYLYL PEPTIDE UTILIZING LOSSEN REARRANGEMENT2023

    • Author(s)
      Junya Hayashi, Daishiro Kobayashi, Masaya Denda, Akira Otaka
    • Organizer
      第60回ペプチド討論会
    • Data Source
      KAKENHI-PROJECT-23K18187
  • [Presentation] Interrupted Pummerer反応によるTrp選択的修飾を利用したOne-potペプチドヘテロ二量化法の開発2023

    • Author(s)
      小林 大志朗, 林 隼矢, 日高 功太, 光村 豊, 大川内 健人, 傳田 将也, 大髙 章
    • Organizer
      第49回反応と合成の進歩シンポジウム
    • Data Source
      KAKENHI-PROJECT-23K27300
  • [Presentation] S-保護システインスルホキシドを利用したトリプトファン選択的修飾法の開発2023

    • Author(s)
      傳田 将也, 野中 智貴, 小林 大志朗, 林 隼矢, 安田 拓真, 光村 豊, 原田 範雄, 稲垣 暢也, 大髙 章
    • Organizer
      日本ケミカルバイオロジー学会 第17回年会
    • Data Source
      KAKENHI-PROJECT-23K27300
  • [Presentation] Lossen転位を利用したペプチドN末端アルデヒド化法の開発と応用2023

    • Author(s)
      林 隼矢, 小林 大志朗, 傳田 将也, 大髙 章
    • Organizer
      第49回反応と合成の進歩シンポジウム
    • Data Source
      KAKENHI-PROJECT-23K18187
  • [Presentation] Cys(MBzl)(O)を利用したTrp位置選択的脂肪鎖修飾法の開発と修飾GIP調製への応用2023

    • Author(s)
      永田 綱基, 野中 智貴, 小林 大志朗, 傳田 将也, 大髙 章
    • Organizer
      第62回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Data Source
      KAKENHI-PROJECT-23K27300
  • [Presentation] Development of acyl transfer-based chemical and chemical biology tools for protein science2021

    • Author(s)
      Akira Shigenaga, Masaya Denda, Akira Otaka
    • Organizer
      Pacifichem 2021 (The International Chemical Congress of Pacific Basin Societies 2021, Symposium “Design of Functional Proteins, Peptides, and Peptidomimetics”)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K21483
  • [Presentation] S-Oアシル転移を基盤とする環状デプシペプチドの合成2020

    • Author(s)
      常松 保乃加, 上田 智子, 左東 大輝, 小宮 千明, 重永 章, 大髙 章
    • Organizer
      日本薬学会第140年会
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] 人工HDLの化学的性状と抗腫瘍効果への影響に関する検討2020

    • Author(s)
      金山 忠史, 大川内 健人, 清水 太郎, 重永 章, 大髙 章, 石田 竜弘, 奥平 桂一郎
    • Organizer
      日本薬学会第140年会
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] 乳がん細胞におけるBIG3-PHB2相互作用を標的とした高持続性架橋ペプチドの開発2020

    • Author(s)
      安養寺 啓太央, 粟飯原 圭佑, 吉丸 哲郎, 西川 祐輔, 小松 正人, 重永 章, 片桐 豊雅, 大髙 章
    • Organizer
      日本薬学会第140年会
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] 安定なα-イミノリン酸エステルの開発とキラルα-アミノリン酸の触媒的不斉合成への応用2020

    • Author(s)
      榊原 拓哉, 猪熊 翼, 増井 香奈, 重永 章, 大髙 章, 山田 健一
    • Organizer
      日本薬学会第140年会
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] 天然マクロライドの全合成が拓く新規多発性骨髄腫治療薬2019

    • Author(s)
      浜田 麻衣, 森崎 巧也, 中山 淳, 寺町 順平, 辻 大輔, 重永 章, 山本 武範, 篠原 康雄, 大髙 章, 伊藤 孝司, 安部 正博, 難波 康祐
    • Organizer
      創薬懇話会2019 in 秋保
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] 安定なα-イミノリン酸エステルへの触媒的不斉付加を用いるキラルα-アミノリン酸の合成2019

    • Author(s)
      榊原 拓哉, 猪熊 翼, 増井 香奈, 重永 章, 大髙 章, 山田 健一
    • Organizer
      第45回反応と合成の進歩シンポジウム
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] がん抑制因子PHB2の部分配列を基盤とした乳がん阻害ペプチドの開発2019

    • Author(s)
      安養寺 啓太央, 粟飯原 圭佑, 吉丸 哲郎, 重永 章, 片桐 豊雅, 大髙 章
    • Organizer
      創薬懇話会2019 in 秋保
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] ペプチドへの直接的不斉反応による異常アミノ酸含有ペプチド新規合成法の開発2019

    • Author(s)
      猪熊 翼, 増井 香奈, 西田 航大, 重永 章, 大髙 章, 山田 健一
    • Organizer
      日本ケミカルバイオロジー学会第14回年会
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] Development of the direct asymmetric indolylation of imino peptide for synthesis of indolylglycine-containing peptide2019

    • Author(s)
      Tsubasa Inokuma, Kana Masui, Kohdai Nishida, Akira Shigenaga, Akira Otaka and Ken-ichi Yamada
    • Organizer
      第56回ペプチド討論会
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] プロテインノックダウン法を用いたチミジル酸合成酵素分解誘導剤開発2019

    • Author(s)
      有井 紗由季, 上田 将弘, 重永 章, 大髙 章, 石田 竜弘, 奥平 桂一郎
    • Organizer
      第58回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] CpG DNAと CXCL14による自然免疫系の協調的な調節メカニズム2019

    • Author(s)
      種子島 幸祐, 三井 貴洋, 岩瀬 璃奈, 成瀬 公人, 重永 章, 大髙 章, 原 孝彦
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] Copper-mediated Ring Opening of Thiazolidine Derivative for Protein Chemical Synthesis2019

    • Author(s)
      Naoto Naruse, Daishiroh Kobayashi, Akira Shigenaga and Akira Otaka
    • Organizer
      27th International Society of Heterocyclic Chemistry Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] 銅塩を利用するシステインS-保護基除去反応の開発2019

    • Author(s)
      小林 大志朗, 成瀬 公人, 重永 章, 大髙 章
    • Organizer
      第45回反応と合成の進歩シンポジウム
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] Chiral Phosphoric Acid-Catalyzed Asymmetric Mannich-Type Reaction Using Imino Peptide as Substrate2019

    • Author(s)
      Tsubasa Inokuma, Kohdai Nishida, Kana Masui, Akira Shigenaga, Akira Otaka and Ken-ichi Yamada
    • Organizer
      第12回 有機触媒シンポジウム
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] 天然に学ぶタンパク質化学とタンパク・ペプチド性医薬品の可能性2019

    • Author(s)
      大髙 章
    • Organizer
      神戸ポートアイランド創薬フォーラム
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] Lossen rearrangement-mediated preparation of N-glyoxylyl peptide without addition of oxidant2019

    • Author(s)
      小林 大志朗, 西田 航大, 猪熊 翼, 重永 章, 大髙 章
    • Organizer
      第56回ペプチド討論会
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] 銅塩を基点とする,タンパク合成を指向した反応開発研究2019

    • Author(s)
      小林 大志朗, 成瀬 公人, 重永 章, 大髙 章
    • Organizer
      創薬懇話会2019 in 秋保
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] Development of acyl transfer-based chemical biology tools for purification/selective labeling of target proteins2019

    • Author(s)
      Akira Shigenaga, Takuya Morisaki, Taiki Kohiki, Masaya Denda, Tsubasa Inokuma and Akira Otaka
    • Organizer
      5th International Symposium for Medicinal Sciences
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] Development of acyl transfer-based chemical biology tools for purification/selective labeling of target proteins.2019

    • Author(s)
      Shigenaga, A.; Morisaki, T.; Kohiki, T.; Denda, M.; Inokuma, T.; Otaka, A.
    • Organizer
      5th International Symposium for Medicinal Sciences
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19492
  • [Presentation] 天然マクロライドの網羅的全合成が拓く新規多発性骨髄腫治療薬の開発研究2019

    • Author(s)
      浜田 麻衣, 中山 淳, 中山 慎一朗, 寺町 順平, 辻 大輔, 重永 章, 安部 正博, 伊藤 孝司, 大髙 章, 難波 康祐
    • Organizer
      2019年度第2回(第30回)日本プロセス化学会東四国フォーラムセミナー
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] Development of Novel Ring-Opening Reaction of N-Terminal Thiazolidine for Chemical Protein Synthesis2019

    • Author(s)
      Naoto Naruse, Daishiroh Kobayashi, Kento Ohkawachi, Akira Shigenaga and Akira Otaka
    • Organizer
      26th American Peptide Symposium/11th International Peptide Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] 腫瘍DDSキャリアとしての人工HDLの調製および動態の評価2019

    • Author(s)
      金山 忠史, 大川内 健人, 清水 太郎, 重永 章, 大髙 章, 石田 竜弘, 奥平 桂一郎
    • Organizer
      日本薬剤学会第34年会
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] チオール導入型DMAP触媒を利用した環状ペプチド合成法の開発2019

    • Author(s)
      大川内 健人, 森本 恭平, 成瀬 公人, 山次 健三, 重永 章, 金井 求, 大髙 章
    • Organizer
      第51回若手ペプチド夏の勉強会
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] ケモカイン CXCL14の脳内ミクログリアに対する働き2019

    • Author(s)
      中川 美帆, 種子島 幸祐, 三井 貴洋, 成瀬 公人, 重永 章, 大髙 章, 佐久間 啓, 原 孝彦
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] Development of methodology for cyclic peptide synthesis using a thiol-incorporated DMAP catalyst.2018

    • Author(s)
      Ohkawachi, K.; Morimoto, K.; Naruse, N.; Yamatsugu, K.; Shigenaga, A.; Kanai, M.; Otaka, A.
    • Organizer
      10th International Peptide Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] CpG DNA/CXCL14複合体に対する候補受容体の発現クローニング2018

    • Author(s)
      三井 貴洋、種子島 幸祐、成瀬 公人、重永 章、大髙 章、原 孝彦
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] Development of anti-cancer peptide based on prohibitin 2.2018

    • Author(s)
      Anyohji, K.; Aihara, K.; Yoshimaru, T.; Shigenaga, A.; Katagiri, T.; Otaka,A.
    • Organizer
      10th International Peptide Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] On-resinチオエステル化法から得られた知見とその応用2018

    • Author(s)
      成瀬 公人、大川内 健人、猪熊 翼、重永 章、大髙 章
    • Organizer
      第50回若手ペプチド夏の勉強会
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] 新規チオール触媒を利用した環状ペプチド合成法の開発2018

    • Author(s)
      大川内 健人、成瀬 公人、重永 章、大髙 章
    • Organizer
      創薬懇話会 2018 in 志賀島
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] 発現タンパク質に適用可能な新規チオエステル合成法の開発2018

    • Author(s)
      小宮 千明、月本 準、上田 将弘、森崎 巧也、猪熊 翼、重永 章、伊藤 孝司、大髙 章
    • Organizer
      創薬懇話会 2018 in 志賀島
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] 人工HDLの化学的性状と体内動態への影響に関する検討2018

    • Author(s)
      金山 忠史、奥平 桂一郎、大川内 健人、清水 太郎、重永 章、大髙 章、石田 竜弘
    • Organizer
      第57回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Data Source
      KAKENHI-PROJECT-17K19492
  • [Presentation] ペプチドイミンに対する不斉1,2-付加を基盤とする非天然アミノ酸含有ペプチドの不斉合成2018

    • Author(s)
      猪熊 翼、岡田 和貴、西田 航大、重永 章、大髙 章、山田 健一
    • Organizer
      第44回反応と合成の進歩シンポジウム
    • Data Source
      KAKENHI-PROJECT-17K19492
  • [Presentation] SECmideを基盤としたターンオン型蛍光クリーバブルリンカーの開発2018

    • Author(s)
      森崎 巧也、重永 章、大髙 章
    • Organizer
      第57回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Data Source
      KAKENHI-PROJECT-17K19492
  • [Presentation] 新規チオール触媒を利用した分子内ライゲーション法の開発2018

    • Author(s)
      大川内 健人、森本 恭平、成瀬 公人、重永 章、金井 求、大髙 章
    • Organizer
      第50回若手ペプチド夏の勉強会
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] がん抑制タンパク質PHB2からの創薬シード発掘2018

    • Author(s)
      安養寺 啓太央、粟飯原 圭祐、吉丸 哲郎、重永 章、片桐 豊雅、大髙 章
    • Organizer
      第50回若手ペプチド夏の勉強会
    • Data Source
      KAKENHI-PROJECT-17K19492
  • [Presentation] 均一修飾タンパク質の合成を施行したタンパク質C末端特異的活性化反応の開発2018

    • Author(s)
      小宮千明、月本 準、森崎巧也、津田雄介、宮島 凜、猪熊 翼、 重永 章、伊藤孝司、大髙 章
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] CXCL14とCpG DNAの相互作用によるTLR9活性化の特異性と責任領域の解析2018

    • Author(s)
      岩瀬 璃奈、成瀬 公人、種子島 幸祐、重永 章、大髙 章、原 孝彦
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] 酵素を利用したチオエステル調製 のためのC末ペプチド配列の最適化2018

    • Author(s)
      上田 将弘、小宮 千明、重永 章、大髙 章
    • Organizer
      第50回若手ペプチド夏の勉強会
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] Development and application of novel protein labeling reagent SEAL.2018

    • Author(s)
      Kohiki, T.; Kato, Y.; Denda, M.; Nishikawa, Y.; YORITA, K.; Sagawa, I.; Inokuma, T.; Shigenaga, A.; Fukui, K.; Otaka, A.
    • Organizer
      10th International Peptide Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19492
  • [Presentation] Combined approach of computation and enzymology to investigate novel D-amino acid oxidase inhibitors.2018

    • Author(s)
      Kato, Y.; Maita, N.; Kohiki, T.; Kurosawa, S.; Nishikawa, Y.; Sagawa, I.; Denda, M.; Inokuma, T.; Shishido, Y.; YORITA, K.; Shigenaga, A.; Otaka, A.; Fukui, K.
    • Organizer
      The 13th International Symposium of the Institute Network for Biomedical Sciences joint with the 3rd Symposium of the Inter-University Research Network for Trans-Omics Medicine
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19492
  • [Presentation] 加水分解酵素を利用したC末端特異的チオエステル化反応の開発2018

    • Author(s)
      小宮 千明、月本 準、上田 将弘、森崎 巧也、猪熊 翼、重永 章、伊藤 孝司、大髙 章
    • Organizer
      第50回若手ペプチド夏の勉強会
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] Preparation of protein thioesters enabled by carboxypeptidase-mediated C-terminal specific hydrazinolysis.2018

    • Author(s)
      Komiya, C.; Tsukimoto, J.; Ueda, M.; Morisaki, T.; Inokuma, T.; Shigenaga, A.; Itou, K.; Otaka, A.
    • Organizer
      10th International Peptide Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] S-アデノシルホモシステイン加水分解酵素の蛍光性基質の開発2018

    • Author(s)
      中西 雅之、古曳 泰規、重永 章、大髙 章、田中 信忠、北出 幸夫、日野 真美、野元 裕
    • Organizer
      第91回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-17K19492
  • [Presentation] Development of method for deprotection of N-terminal thiazolidine derivative using copper salt for chemical protein synthesis.2018

    • Author(s)
      Naruse, N.; Matsumoto, K.; Shigenaga, A.; Otaka, A.
    • Organizer
      10th International Peptide Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] 安定なイミンを用いたα-アミノリン酸の実用的不斉合成2018

    • Author(s)
      榊原 拓哉、猪熊 翼、重永 章、大髙 章、山田 健一
    • Organizer
      創薬懇話会 2018 in 志賀島
    • Data Source
      KAKENHI-PROJECT-17K19492
  • [Presentation] N-Sアシル基転移速度 の向上を指向した新規補助基の開発2018

    • Author(s)
      河野 誉良、成瀬 公人、猪熊 翼、重永 章、大髙 章
    • Organizer
      第50回若手ペプチド夏の勉強会
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] アシル基転移反応を基盤とする標的タンパク質精製・機能解明ツールの開発2018

    • Author(s)
      重永 章、大高 章
    • Organizer
      日本薬学会第138年会(シンポジウム 中分子創薬研究のフロンティア)
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K07858
  • [Presentation] Novel methodology for the synthesis of-indolyl-glycine containing peptidevia direct asymmetric FriedelCrafts reactionto peptidyl imine.2018

    • Author(s)
      Inokuma, T.; Nishida, K.; Shigenaga, A.; Yamada, K.; Otaka, A.
    • Organizer
      35th European Peptide Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19492
  • [Presentation] トレーサブルリンカー を用いた共有結合性低分子の標的同定2018

    • Author(s)
      森崎 巧也、中山 淳、難波 康祐、重永 章、大髙 章
    • Organizer
      第50回若手ペプチド夏の勉強会
    • Data Source
      KAKENHI-PROJECT-17K19492
  • [Presentation] 酵素を利用したチオエステル化反応の効率化を指向したペプチドC末配列の修飾2018

    • Author(s)
      上田 将弘、小宮 千明、重永 章、大髙 章
    • Organizer
      第57回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] 非天然側鎖構造を有するα-アミノリン酸の実用的不斉合成2018

    • Author(s)
      榊原 拓哉、猪熊 翼、重永 章、大髙 章、山田 健一
    • Organizer
      第57回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Data Source
      KAKENHI-PROJECT-17K19492
  • [Presentation] チオエステル等価体ユニットを利用した環状ペプチド効率的合成法の開発2017

    • Author(s)
      寺中孝久、粟飯原圭佑、山岡浩輔、猪熊 翼、重永 章、大髙 章
    • Organizer
      第35回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] アルギニンペプチドのグリコサミノグリカン糖鎖を介した細胞膜透過機構に関する物理化学的解析2017

    • Author(s)
      灘井亮,原矢佑樹,西辻和親,内村健治,加藤くみ子,重永章,川上徹,大高章,北條裕信,坂下直実,斎藤博幸
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-25
    • Data Source
      KAKENHI-PROJECT-25293006
  • [Presentation] N-Sアシル基転移を基盤としたタンパク質ラベル化法を用いたD-アミノ酸酸化酵素阻害剤の結合サイト解明研究2017

    • Author(s)
      古曳泰規、加藤有介、西川祐輔、頼田和子、佐川幾子、傳田将也、猪熊 翼、重永 章、福井 清、大髙 章
    • Organizer
      第56回日本薬学会・日本薬剤師会・日本大学病院薬剤師会中国四国支部学術大会
    • Data Source
      KAKENHI-PROJECT-17K19492
  • [Presentation] タンパク質C末端特異的活性化反応の開発2017

    • Author(s)
      小宮千明、津田雄介、宮島 凜、猪熊 翼、重永 章、大髙 章
    • Organizer
      第35回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] チオエステル等価体として機能するタンパク質の化学合成のための新規補助基の開発2017

    • Author(s)
      河野誉良、成瀬公人、猪熊 翼、重永 章、大髙 章
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター、東北大学川内地区(宮城県仙台市)
    • Year and Date
      2017-03-24
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] DAO分子表面に結合する阻害分子の計算科学的解析2017

    • Author(s)
      加藤有介、古曳泰規、西川祐輔、佐川幾子、傳田将也、猪熊 翼、宍戸裕二、重永 章、大髙 章、福井 清
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Data Source
      KAKENHI-PROJECT-17K19492
  • [Presentation] N-S-acyl-transfer-mediated On-resin Formation of Thioester with Practical Application to Peptide Synthesis.2017

    • Author(s)
      成瀬公人、大川内健人、猪熊 翼、 重永 章、伊藤孝司、大髙 章
    • Organizer
      第54回ペプチド討論会
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] N-Sulfanylethylanilideを用いた細胞内標的タンパク質ラベル化法の開発2017

    • Author(s)
      古曳泰規、傳田将也、藤川昴樹、猪熊 翼、重永 章、小暮健太朗、大高 章
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2017-03-24
    • Data Source
      KAKENHI-PROJECT-15K07858
  • [Presentation] Development of methodology for producing thioesters from naturally occurring peptide sequence.2017

    • Author(s)
      小宮千明、月本 準、森崎巧也、津田雄介、宮島 凜、猪熊 翼、 重永 章、伊藤孝司、大髙 章
    • Organizer
      第54回ペプチド討論会
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] ペプチド創薬を指向した非天然アミノ酸含有ペプチドの新規効率的合成法の開発2017

    • Author(s)
      西田航大、猪熊 翼、重永 章、大髙 章
    • Organizer
      創薬懇話会2017 in 加賀
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] Screening of the effectors for human D-amino acid oxidase and the analyses of structure-activity relationships2017

    • Author(s)
      Kazuko YORITA, Sumire Kurosawa, Yuri Yoshida, Yoshiki Kashiwada, Shigeki Sano, Akira Otaka and Kiyoshi Fukui
    • Organizer
      The 19th triennial International Symposium on Flavins and Flavoproteins
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19492
  • [Presentation] タンパク質化学合成のための新規N-ペプチジルアニリド型補助基の開発2017

    • Author(s)
      河野誉良、成瀬公人、猪熊 翼、重永 章、大髙 章
    • Organizer
      創薬懇話会2017 in 加賀
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] On-resinチオエステル化を利用した環状ペプチド合成法の開発2017

    • Author(s)
      大川内健人、成瀬公人、重永 章、大髙 章
    • Organizer
      第56回日本薬学会・日本薬剤師会・日本大学病院薬剤師会中国四国支部学術大会
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] 光応答性アポリポタンパク質の開発2017

    • Author(s)
      川原遥華、 奥平桂一郎、 宮下直樹、 津田雄介、 森本恭平、 辻 耕平、 重永 章、 大髙 章、 石田竜弘
    • Organizer
      日本薬剤学会第32年会
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] Application of N-Sulfanylethylanilide(SEAlide) Unit to Protein Chemical Synthesis and Protein Enrichment2017

    • Author(s)
      Akira Otaka
    • Organizer
      American Peptide Symposium 2017
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] Development of anti-breast cancer stapled peptides targeting BIG3-PHB2 interaction2017

    • Author(s)
      Akira Otaka
    • Organizer
      AIMECS 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19492
  • [Presentation] Development of long-lasting stapled peptides targeting BIG3-PHB2 interaction in breast cancer cells2017

    • Author(s)
      Akira Otaka, Keisuke Aihara, Tetsuro Yoshimaru, Akira Shigenaga and Toyomasa Katagiri
    • Organizer
      The 6th Pharmaceutical Sciences World Congress 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] チオエステル等価体として機能するタンパク質の化学合成のための新規補助基の開発2017

    • Author(s)
      河野誉良、成瀬公人、猪熊 翼、重永 章、大髙 章
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター、東北大学川内地区(宮城県仙台市)
    • Year and Date
      2017-03-24
    • Data Source
      KAKENHI-PROJECT-15K14979
  • [Presentation] Development of N-sulfanyltehylanilide (SEAlide)-based traceable linker for enrichment and selective labeling of target proteins2016

    • Author(s)
      森崎巧也、傳田将也、山本 純、辻 大輔、猪熊 翼、伊藤孝司、重永 章、大高 章
    • Organizer
      第53回ペプチド討論会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Year and Date
      2016-10-26
    • Data Source
      KAKENHI-PROJECT-15K07858
  • [Presentation] “SEAL-tag”を基盤とした細胞内での標的タンパク質ラベル化法の開発2016

    • Author(s)
      古曳泰規、傳田将也、森崎巧也、辻 大輔、猪熊 翼、伊藤孝司、重永 章、大高 章
    • Organizer
      日本ケミカルバイオロジー学会第11回年会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Year and Date
      2016-06-15
    • Data Source
      KAKENHI-PROJECT-15K07858
  • [Presentation] Intein-inspired Amide Bond Processing Device.2016

    • Author(s)
      Chiaki Komiya, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka
    • Organizer
      34th European Peptide Symposium 2016 & 8th International Peptide Symposium
    • Place of Presentation
      Leipzig (Germany)
    • Year and Date
      2016-09-01
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K14979
  • [Presentation] 光応答型チオエステル等価体を用いた多成分One-pot NCL法の開発研究2016

    • Author(s)
      山岡浩輔、粟飯原圭佑、 成瀬公人、 猪熊 翼、 重永 章、 大髙 章
    • Organizer
      創薬懇話会2016 in 蓼科
    • Place of Presentation
      エクシブ蓼科(長野県茅野市)
    • Year and Date
      2016-06-30
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] 標的タンパク質精製ツール“SEAlide-based traceable linker”の開発2016

    • Author(s)
      森崎巧也、傳田将也、辻 大輔、山本 純、猪熊 翼、伊藤孝司、重永 章、大高 章
    • Organizer
      日本ケミカルバイオロジー学会第11回年会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Year and Date
      2016-06-15
    • Data Source
      KAKENHI-PROJECT-15K07858
  • [Presentation] タンパク質位置選択的修飾を指向したチオエステル調製法の開発2016

    • Author(s)
      津田雄介、重永 章、辻 耕平、傳田将也、佐藤浩平、北風圭介、中村太寛、猪熊 翼、伊藤孝司、大高 章
    • Organizer
      第34回メディシナルケミストリーシンポジウム
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-15K07858
  • [Presentation] 光応答性アポA-I模倣ペプチドの開発研究2016

    • Author(s)
      川原遙華、奥平桂一郎、辻耕平、津田雄介、森本恭平、木村仁、假屋園大和、大村理沙、市野晨人、杉原涼、西辻和親、重永章、坂下直実、大高章、斎藤博幸
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2016-03-27
    • Data Source
      KAKENHI-PROJECT-25293006
  • [Presentation] Intein-inspired Amide Bond Processing Device.2016

    • Author(s)
      Chiaki Komiya, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka
    • Organizer
      34th European Peptide Symposium 2016 & 8th International Peptide Symposium
    • Place of Presentation
      Leipzig (Germany)
    • Year and Date
      2016-09-01
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] One-pot sequential native chemical ligations using photocaged crypto-thioester2016

    • Author(s)
      山岡浩輔、粟飯原圭佑、成瀬公人、猪熊 翼、重永 章、大高 章
    • Organizer
      第53回ペプチド討論会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Year and Date
      2016-10-26
    • Data Source
      KAKENHI-PROJECT-15K07858
  • [Presentation] Iowa変異型アポA-Iによる脂質膜環境下でのアミロイド線維形成2016

    • Author(s)
      水口智晴、三河志穂、馬場照彦、島内寿徳、重永章、奥平桂一郎、大高章、斎藤博幸
    • Organizer
      第4回日本アミロイドーシス研究会学術集会
    • Place of Presentation
      KKRホテル東京(東京都千代田区)
    • Data Source
      KAKENHI-PROJECT-25293006
  • [Presentation] One-Pot/Sequential Native Chemical Ligation Using Photo-responsive Crypto-thioester2016

    • Author(s)
      粟飯原圭佑、山岡浩輔、成瀬公人、猪熊 翼、重永 章、大高 章
    • Organizer
      34th European Peptide Symposium 2016 & 8th International Peptide Symposium
    • Place of Presentation
      Leipzig (German)
    • Year and Date
      2016-09-04
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K07858
  • [Presentation] タンパク質位置選択的修飾を指向したチオエステル調製法の開発2016

    • Author(s)
      津田雄介、重永 章、辻 耕平、傳田将也、佐藤浩平、北風圭介、中村太寛、猪熊 翼、伊藤孝司、大髙 章
    • Organizer
      第34回メディシナルケミストリーシンポジウム
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] ペプチド化学を基盤としたケミカルバイオロジー研究のための基盤技術の開拓2016

    • Author(s)
      重永 章、大高 章
    • Organizer
      日本薬学会第136年会(シンポジウム「疾患代謝」から解明される生命現象と創薬研究への応用)
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-03-26
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K07858
  • [Presentation] Regioselective S-Cyanylation-mediated Preparation of Peptide Thioester .2016

    • Author(s)
      Akira Otaka, Rin Miyajima, Yusuke Tsuda and Akira Shigenaga.
    • Organizer
      16th Akabori Conference Japanese-German Symposium on Peptide Science
    • Place of Presentation
      六甲山ホテル(兵庫県神戸市)
    • Year and Date
      2016-05-23
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] Development of stapled peptides targeting BIG3-PHB2 interaction in breast cancer cells2016

    • Author(s)
      粟飯原 圭佑, 吉丸 哲郎, 小松 正人, 重永 章, 片桐 豊雅, 大髙 章
    • Organizer
      第53回ペプチド討論会/日本ペプチド学会
    • Place of Presentation
      京都テルサ 京都府京都市
    • Year and Date
      2016-10-26
    • Data Source
      KAKENHI-PROJECT-16H05153
  • [Presentation] Effect of heparin on amyloid fibril formation of apoA-I fragment peptides2016

    • Author(s)
      Shiho Mikawa, Chiharu Mizuguchi, Izumi Morita, Hiroyuki Oyama, Teruhiko Baba, Akira Shigenaga, Toshinori Shimanouchi, Norihiro Kobayashi, Akira Otaka, Kenichi Akaji, and Hiroyuki Saito
    • Organizer
      第53回ペプチド討論会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Year and Date
      2016-10-26
    • Data Source
      KAKENHI-PROJECT-25293006
  • [Presentation] Regioselective S-Cyanylation-mediated Preparation of Peptide Thioester .2016

    • Author(s)
      Akira Otaka, Rin Miyajima, Yusuke Tsuda and Akira Shigenaga.
    • Organizer
      16th Akabori Conference Japanese-German Symposium on Peptide Science
    • Place of Presentation
      六甲山ホテル(兵庫県神戸市)
    • Year and Date
      2016-05-23
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K14979
  • [Presentation] SEAlideを基盤とした標的タンパク質精製ツールの開発研究2016

    • Author(s)
      森崎巧也、傳田将也、辻 大輔、山本 純、猪熊 翼、伊藤孝司、重永 章、大高 章
    • Organizer
      第34回メディシナルケミストリーシンポジウム
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-15K07858
  • [Presentation] Intein-inspired Amide Bond Processing Device2016

    • Author(s)
      小宮千明、粟飯原圭佑、猪熊 翼、重永 章、大高 章
    • Organizer
      34th European Peptide Symposium 2016 & 8th International Peptide Symposium
    • Place of Presentation
      Leipzig (German)
    • Year and Date
      2016-09-04
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K07858
  • [Presentation] SULFATED GLYCOSAMINOGLYCANS PROMOTE CELL MEMBRANE PENETRATION OF ARGININE PEPTIDES VIA ENTHALPY-DRIVEN INTERACTIONS2016

    • Author(s)
      Ryo Nadai, Yuki Haraya, Kazuchika Nishitsuji, Kenji Uchimura, Kumiko Kato, Akira Shigenaga, Toru Kawakami, Akira Otaka, Hironobu Hojo, Naomi Sakashita, Hiroyuki Saito
    • Organizer
      第53回ペプチド討論会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Year and Date
      2016-10-26
    • Data Source
      KAKENHI-PROJECT-25293006
  • [Presentation] タンパク質位置選択的修飾を指向したチオエステル調製法の開発2016

    • Author(s)
      津田雄介、重永 章、辻 耕平、傳田将也、佐藤浩平、北風圭介、中村太寛、猪熊 翼、伊藤孝司、大髙 章
    • Organizer
      第34回メディシナルケミストリーシンポジウム
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-15K14979
  • [Presentation] Tailored Synthesis of 162-Residue S-Monoglycosylated GM2-Activator Protein (GM2AP) Analogues Applicable to the Preparation of a Protein Library.2016

    • Author(s)
      中村太寛、重永 章、成瀬公人、猪熊 翼、大髙 章
    • Organizer
      第53回ペプチド討論会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Year and Date
      2016-10-25
    • Data Source
      KAKENHI-PROJECT-16H02611
  • [Presentation] 光応答型チオエステル等価体を用いた多成分One-pot NCL法の開発研究2016

    • Author(s)
      山岡浩輔、粟飯原圭佑、成瀬公人、猪熊 翼、重永 章、大高 章
    • Organizer
      創薬懇話会2016 in 蓼科
    • Place of Presentation
      エクシブ蓼科(長野県茅野市)
    • Year and Date
      2016-06-30
    • Data Source
      KAKENHI-PROJECT-15K07858
  • [Presentation] アルギニンペプチドの細胞膜透過はグリコサミノグリカン糖鎖へのエンタルピー依存的結合によって促進される2016

    • Author(s)
      灘井亮,原矢佑樹,西辻和親,内村健治,加藤くみ子,重永章,川上徹,大高章,北條裕信,坂下直実,斎藤博幸
    • Organizer
      日本膜学会第38年会
    • Place of Presentation
      早稲田大学西早稲田キャンパス(東京都新宿区)
    • Year and Date
      2016-05-10
    • Data Source
      KAKENHI-PROJECT-25293006
  • [Presentation] Tailored Synthesis of 162-Residue S-Monoglycosylated GM2-Activator Protein (GM2AP) Analogues Applicable to the Preparation of a Protein Library.2016

    • Author(s)
      中村太寛、重永 章、成瀬公人、猪熊 翼、大髙 章
    • Organizer
      第53回ペプチド討論会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Year and Date
      2016-10-26
    • Data Source
      KAKENHI-PROJECT-15K14979
  • [Presentation] 光応答型チオエステル等価体を用いた多成分One-pot NCL法の開発研究2016

    • Author(s)
      山岡浩輔、粟飯原圭佑、 成瀬公人、 猪熊 翼、 重永 章、 大髙 章
    • Organizer
      創薬懇話会2016 in 蓼科
    • Place of Presentation
      エクシブ蓼科(長野県茅野市)
    • Year and Date
      2016-06-30
    • Data Source
      KAKENHI-PROJECT-15K14979
  • [Presentation] アミロイドーシス変異アポA-I Iowaの脂質膜結合状態の解析2016

    • Author(s)
      水口智晴,三河志穂,馬場照彦,島内寿徳,重永章,奥平桂一郎,大高章,斎藤博幸
    • Organizer
      膜シンポジウム2016
    • Place of Presentation
      関西大学(大阪府吹田市)
    • Year and Date
      2016-12-01
    • Data Source
      KAKENHI-PROJECT-25293006
  • [Presentation] シクロデキストリン架橋型キトサン-pH応答性ペプチド複合体による細胞コレステロール排出促進作用2015

    • Author(s)
      武知佑樹, 田中健斗,辻耕平,麻見安雄,井澤浩則,重永章,大高章,川上亘作,斎藤博幸
    • Organizer
      日本膜学会第37年会
    • Place of Presentation
      早稲田大学西早稲田キャンパス(東京都)
    • Year and Date
      2015-05-14
    • Data Source
      KAKENHI-PROJECT-25293006
  • [Presentation] 化学合成によるタンパク質製剤調製への挑戦2015

    • Author(s)
      大髙 章, 佐藤 浩平, 重永 章
    • Organizer
      第15回日本蛋白質科学会年会
    • Place of Presentation
      あわぎんホール(徳島県徳島市)
    • Year and Date
      2015-06-24
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K14979
  • [Presentation] N-Sulfanylethylanilide peptide as a crypto thioester for protein chemical synthesis2015

    • Author(s)
      Akira Otaka
    • Organizer
      5th Modern Solid Phase Peptide Synthesis & Its Application Symposium
    • Place of Presentation
      Queensland Australia
    • Year and Date
      2015-10-22
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K14979
  • [Presentation] Preparation of peptide thioesters from naturally occuring sequences using a chemical protocol2015

    • Author(s)
      宮島 凜, 津田 雄介, 猪熊 翼, 重永 章, 大髙 章
    • Organizer
      第52回ペプチド討論会
    • Place of Presentation
      平塚市中央公民館(神奈川県平塚市)
    • Year and Date
      2015-11-16
    • Data Source
      KAKENHI-PROJECT-15K14979
  • [Presentation] タンパク質自己編集システムを範としたアミド結合切断反応の開発2015

    • Author(s)
      小宮千明、粟飯原圭佑、猪熊 翼、重永 章、大高 章
    • Organizer
      第三十一回若手化学者のための化学道場
    • Place of Presentation
      淡路夢舞台国際会議場(兵庫県淡路市)
    • Year and Date
      2015-08-27
    • Data Source
      KAKENHI-PROJECT-15K07858
  • [Presentation] アポA-Iアミロイド線維形成に与える脂質膜とヘパリンの影響2015

    • Author(s)
      三河志穂、水口智晴、辻耕平、重永章、島内寿徳、大高章、斎藤博幸
    • Organizer
      日本膜学会第37年会
    • Place of Presentation
      早稲田大学西早稲田キャンパス(東京都)
    • Year and Date
      2015-05-14
    • Data Source
      KAKENHI-PROJECT-25293006
  • [Presentation] インテインに学ぶ標的タンパク質研究手法の開発2014

    • Author(s)
      大高 章、重永 章
    • Organizer
      日本薬学会第134回年会
    • Place of Presentation
      熊本大学(熊本県熊本市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-25670058
  • [Presentation] インテインに学ぶ標的タンパク質研究手法の開発2014

    • Author(s)
      大高 章、重永 章
    • Organizer
      日本薬学会第134回年会
    • Place of Presentation
      熊本大学(熊本県)
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-24102521
  • [Presentation] 標的タンパク質の効率的濃縮および選択的ラベル化を可能とする新規リンカー分子の開発2014

    • Author(s)
      森崎巧也、山本 純、重永 章、佐藤陽一、猪熊 翼、山内あい子、大高 章
    • Organizer
      日本薬学会第134回年会
    • Place of Presentation
      熊本大学(熊本県熊本市)
    • Data Source
      KAKENHI-PROJECT-25670058
  • [Presentation] フラグメントペプチドを用いたアポA-Iアミロイド線維形成領域の同定2014

    • Author(s)
      足立愛美,辻耕平,川島浩之,重永章,長尾耕治郎,赤路健一,大高章,斎藤博幸
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本市総合体育館(熊本県)
    • Data Source
      KAKENHI-PROJECT-25293006
  • [Presentation] GM2活性化タンパク質の収束的合成研究2014

    • Author(s)
      佐藤浩平、北風圭介、坂本 健、重永 章、辻 大輔、伊藤孝司、大高 章
    • Organizer
      日本薬学会第134回年会
    • Place of Presentation
      熊本大学(熊本県熊本市)
    • Data Source
      KAKENHI-PROJECT-24390026
  • [Presentation] ラベル化試薬“SEAL-tag”の開発とCOX-1およびhCA1のラベル化2014

    • Author(s)
      傳田将也、山本 純、佐藤浩平、坂本 健、重永 章、佐藤陽一、山内あい子、大高 章
    • Organizer
      日本薬学会第134回年会
    • Place of Presentation
      熊本大学(熊本県熊本市)
    • Data Source
      KAKENHI-PROJECT-25670058
  • [Presentation] インテインに学ぶ標的タンパク質研究手法の開発2014

    • Author(s)
      大高 章、重永 章
    • Organizer
      日本薬学会第134回年会
    • Place of Presentation
      熊本大学(熊本県熊本市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-24390026
  • [Presentation] 標的タンパク質の効率的濃縮および選択的ラベル化を可能とする新規リンカー分子の開発2014

    • Author(s)
      森崎巧也、山本 純、重永 章、佐藤陽一、猪熊 翼、山内あい子、大高 章
    • Organizer
      日本薬学会第134回年会
    • Place of Presentation
      熊本大学(熊本県)
    • Data Source
      KAKENHI-PUBLICLY-24102521
  • [Presentation] 標的タンパク質を釣り上げろ!~トレーサブルリンカーの開発~2013

    • Author(s)
      山本 純、北 未来、重永 章、佐藤陽一、山内あい子、大高 章
    • Organizer
      第45回若手ペプチド夏の勉強会
    • Place of Presentation
      八王子セミナーハウス(東京都)
    • Data Source
      KAKENHI-PUBLICLY-24102521
  • [Presentation] Development of thiol-responsive traceable linker for efficient enrichment and selective labeling of target proteins2013

    • Author(s)
      山本 純(大高 章)
    • Organizer
      4th Asia-Pacific International Peptide Symposium, 50th Japanese Peptide Symposium
    • Place of Presentation
      ホテル阪急エキスポパーク(大阪府)
    • Year and Date
      2013-11-07
    • Data Source
      KAKENHI-PROJECT-23390026
  • [Presentation] Application of peptidyl prolyl thioesters to native chemical ligation2013

    • Author(s)
      中村太寛、重永章、佐藤浩平、津田雄介、坂本健、大高章
    • Organizer
      4th Asia-Pacific International Peptide Symposium, 50th Japanese Peptide Symposium
    • Place of Presentation
      ホテル阪急エキスポパーク(大阪府吹田市)
    • Data Source
      KAKENHI-PROJECT-24390026
  • [Presentation] Chemical Protein Synthesis Using N-Sulfanylethylanilide Peptid.2012

    • Author(s)
      Otaka, A
    • Organizer
      The 14rd Akabori Conference
    • Place of Presentation
      北海道
    • Year and Date
      2012-09-12
    • Data Source
      KAKENHI-PROJECT-23659055
  • [Presentation] 情報発信型人工タンパク質創製に向けた有機・生物有機化学的挑戦2012

    • Author(s)
      大高 章
    • Organizer
      第101回有機合成シンポジウム2012年【春】
    • Place of Presentation
      慶應義塾大学薬学部マルチメディア講堂(東京都)
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-24102521
  • [Presentation] 情報発信型人工タンパク質創製に向けた有機・生物有機化学的挑戦2012

    • Author(s)
      大高 章
    • Organizer
      第101回有機合成シンポジウム2012年【春】
    • Place of Presentation
      慶應義塾大学薬学部マルチメディア講堂(東京都)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23659055
  • [Presentation] Development of ``Tracable Linker''for Protein Idebtification Using Stimulus-responsive Amino Acid2012

    • Author(s)
      Otaka A
    • Organizer
      The 1st International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity
    • Place of Presentation
      京都センチュリーホテル(京都府)
    • Data Source
      KAKENHI-PUBLICLY-24102521
  • [Presentation] Chemical Protein Synthesis Using N-Sulfanylethylanilide Peptid2012

    • Author(s)
      Otaka A
    • Organizer
      The 14rd Akabori Conference
    • Place of Presentation
      ヒルトンニセコビレッジ (北海道)(招待・依頼講演)
    • Year and Date
      2012-09-12
    • Data Source
      KAKENHI-PROJECT-24390026
  • [Presentation] N-Sulfanylethylanilides as a Versatile Chemical Device for the Protein Chemistry2012

    • Author(s)
      Otaka, A
    • Organizer
      2012 SNU symposium on Medicinal Chemistry
    • Place of Presentation
      ソウル大学, Seoul, Korea
    • Year and Date
      2012-05-15
    • Data Source
      KAKENHI-PROJECT-23659055
  • [Presentation] N-Sulfanylethylanilides as a Versatile Chemical Device for the Protein Chemistry2012

    • Author(s)
      Otaka A
    • Organizer
      2012 SNU symposium on Medicinal Chemistry
    • Place of Presentation
      ソウル国立大学薬学部 (Seoul, Korea)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23390026
  • [Presentation] 情報発信型人工タンパク質創製に向けた有機・生物有機化学的挑戦2012

    • Author(s)
      大高 章
    • Organizer
      アステラス製薬シンポジウム
    • Place of Presentation
      アステラスつくば研究センター(茨城県)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23390026
  • [Presentation] Chemical Protein Synthesis Using N-Sulfanylethylanilide Peptid2012

    • Author(s)
      Otaka A
    • Organizer
      The 14rd Akabori Conference
    • Place of Presentation
      ヒルトンニセコビレッジ(北海道)
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-24102521
  • [Presentation] N-Sulfanylethylanilide peptide for peptide engineering2012

    • Author(s)
      Otaka A
    • Organizer
      The Sixth Peptide Engineering Meeting
    • Place of Presentation
      Emory大学コンファレンスセンター (Atlanta, USA)
    • Data Source
      KAKENHI-PUBLICLY-24102521
  • [Presentation] N-Sulfanylethylanilides as a Versatile Chemical Device for the Protein Chemistry2012

    • Author(s)
      Otaka, A
    • Organizer
      2012 SNU symposium on Medicinal Chemistry
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2012-05-14
    • Data Source
      KAKENHI-PROJECT-21390031
  • [Presentation] Chemical Protein Synthesis Using N-Sulfanylethylanilide Peptid2012

    • Author(s)
      Otaka A
    • Organizer
      The 14rd Akabori Conference
    • Place of Presentation
      ヒルトンニセコビレッジ(北海道)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23390026
  • [Presentation] 情報発信型人工タンパク質創製に向けた有機・生物有機化学的挑戦2012

    • Author(s)
      大高 章
    • Organizer
      第101回有機合成シンポジウム2012年【春】
    • Place of Presentation
      慶應義塾大学薬学部マルチメディア講堂(東京都)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23390026
  • [Presentation] 情報発信型人工タンパク質創製に向けた有機・生物有機化学的挑戦2012

    • Author(s)
      大高 章
    • Organizer
      アステラス製薬シンポジウム
    • Place of Presentation
      アステラスつくば研究センター(茨城県)
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-24102521
  • [Presentation] N-Sulfanylethylanilide peptide for peptide engineering2012

    • Author(s)
      Otaka A
    • Organizer
      The Sixth Peptide Engineering Meeting
    • Place of Presentation
      Emory大学コンファレンスセンター (Atlanta, USA)
    • Data Source
      KAKENHI-PROJECT-23659055
  • [Presentation] N-Sulfanylethylanilide peptide for peptide engineering2012

    • Author(s)
      Otaka A
    • Organizer
      The Sixth Peptide Engineering Meeting
    • Place of Presentation
      Emory大学コンファレンスセンター (Atlanta, USA)
    • Year and Date
      2012-10-02
    • Data Source
      KAKENHI-PROJECT-24390026
  • [Presentation] N-Sulfanylethylanilides as a Versatile Chemical Device for the Protein Chemistry2012

    • Author(s)
      Otaka A
    • Organizer
      2012 SNU symposium on Medicinal Chemistry
    • Place of Presentation
      ソウル国立大学薬学部 (Seoul, Korea)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23659055
  • [Presentation] Chemical Protein Synthesis Using N-Sulfanylethylanilide Peptid2012

    • Author(s)
      Otaka A
    • Organizer
      The 14rd Akabori Conference
    • Place of Presentation
      ヒルトンニセコビレッジ(北海道)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23659055
  • [Presentation] 情報発信型人工タンパク質創製に向けた有機・生物有機化学的挑戦2012

    • Author(s)
      大高 章
    • Organizer
      アステラス製薬シンポジウム
    • Place of Presentation
      アステラスつくば研究センター(茨城県)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23659055
  • [Presentation] 情報発信型人工タンパク質創製に向けた有機・生物有機化学的挑戦2012

    • Author(s)
      大高 章
    • Organizer
      アステラス製薬シンポジウム
    • Place of Presentation
      アステラスつくば研究センター (茨城県)(招待・依頼講演)
    • Year and Date
      2012-08-08
    • Data Source
      KAKENHI-PROJECT-24390026
  • [Presentation] 情報発信型人工タンパク質創製に向けた有機・生物有機化学的挑戦2012

    • Author(s)
      大高 章
    • Organizer
      第101回有機合成シンポジウム 2012 年【春】
    • Place of Presentation
      慶應義塾大学、東京都
    • Year and Date
      2012-06-06
    • Data Source
      KAKENHI-PROJECT-23659055
  • [Presentation] N-Sulfanylethylanilide peptide for peptide engineering2012

    • Author(s)
      Otaka A
    • Organizer
      The Sixth Peptide Engineering Meeting
    • Place of Presentation
      Emory大学コンファレンスセンター (Atlanta, USA)
    • Data Source
      KAKENHI-PROJECT-23390026
  • [Presentation] 情報発信型人工タンパク質創製に向けた有機・生物有機化学的挑戦2012

    • Author(s)
      大高 章
    • Organizer
      第101回有機合成シンポジウム2012年【春】
    • Place of Presentation
      慶應義塾大学薬学部マルチメディア講堂 (東京都)(招待・依頼講演)
    • Year and Date
      2012-06-06
    • Data Source
      KAKENHI-PROJECT-24390026
  • [Presentation] N-Sulfanylethylanilides as a Versatile Chemical Device for the Protein Chemistry2012

    • Author(s)
      Otaka A
    • Organizer
      2012 SNU symposium on Medicinal Chemistry
    • Place of Presentation
      ソウル国立大学薬学部 (Seoul, Korea)
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-24102521
  • [Presentation] N-Sulfanylethylanilides as a Versatile Chemical Device for the Protein Chemistry2012

    • Author(s)
      Otaka A
    • Organizer
      2012 SNU symposium on Medicinal Chemistry
    • Place of Presentation
      ソウル国立大学薬学部 (Seoul, Korea)(招待・依頼講演)
    • Year and Date
      2012-05-14
    • Data Source
      KAKENHI-PROJECT-24390026
  • [Presentation] Development of nucleocytoplasmic shuttle peptide using stimulus-responsive processing device2011

    • Author(s)
      大高章
    • Organizer
      日本生物物理学会第49回年会
    • Place of Presentation
      兵庫県立大学姫路書写キャンパス(兵庫県)
    • Year and Date
      2011-09-16
    • Data Source
      KAKENHI-PROJECT-23390026
  • [Presentation] Development of nucleocytoplasmic shuttle peptide using stimulus-responsive processing device2011

    • Author(s)
      大高章
    • Organizer
      日本生物物理学会第49回年会
    • Place of Presentation
      兵庫県立大学(姫路市)(招待講演)
    • Year and Date
      2011-09-16
    • Data Source
      KAKENHI-PROJECT-21390031
  • [Presentation] Development of nucleocytoplasmic shuttle peptide using stimulus-responsive processing device2011

    • Author(s)
      大高 章
    • Organizer
      日本生物物理学会第49回年会(招待講演)
    • Place of Presentation
      兵庫県立大学(姫路市)
    • Data Source
      KAKENHI-PROJECT-23659055
  • [Presentation] Development of nucleocytoplasmic shuttle peptide using stimulus-responsive processing device2011

    • Author(s)
      大高 章、重永 章
    • Organizer
      日本生物物理学会第49回年会
    • Place of Presentation
      兵庫県立大学、兵庫県
    • Year and Date
      2011-09-16
    • Data Source
      KAKENHI-PROJECT-23659055
  • [Presentation] Development of peptide bond cleavage device and its application for chemical biology use2010

    • Author(s)
      大高章
    • Organizer
      The 13rd Akabori Conference
    • Place of Presentation
      Leipzig, Germany
    • Year and Date
      2010-09-11
    • Data Source
      KAKENHI-PROJECT-21390031
  • [Presentation] Development of amide bond cleavage device with application to chemical biology use2010

    • Author(s)
      大高章
    • Organizer
      5th International Peptide Symposium in conjunction with 47th Japanese Peptide Symposium
    • Place of Presentation
      京都市
    • Year and Date
      2010-12-09
    • Data Source
      KAKENHI-PROJECT-21390031
  • [Presentation] Development of amide bond cleavage device with application to chemical biology use2010

    • Author(s)
      Otaka, A.; Shigenaga, A
    • Organizer
      5th International Peptide Symposium in conjunction with 47th Japanese Peptide Symposium
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-12-05
    • Data Source
      KAKENHI-PROJECT-21390031
  • [Presentation] 分子内NCLを利用した環状ペプチド合成法の開発(2)2009

    • Author(s)
      西山由希子、中本亜樹、重永章、大高章
    • Organizer
      日本薬学会第129回年会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] 分子内NCLを利用した環状ペプチド合成法の開発(1)2009

    • Author(s)
      前田奈美、津田修吾、石澤祥衣、重永章、大高章
    • Organizer
      日本薬学会第129回年会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] 光刺激応答型アミド結合切断反応のケージドセラミド創製への応用2009

    • Author(s)
      平川寛子、西岡直美、山口圭子、重永童、大高章
    • Organizer
      日本薬学会第129回年会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] Amide bond cleavage for the preparation of functional peptides2009

    • Author(s)
      大高 章
    • Organizer
      Roche Colorado Corporation Peptide Symposium
    • Place of Presentation
      Colorado, USA
    • Year and Date
      2009-09-27
    • Data Source
      KAKENHI-PROJECT-18032051
  • [Presentation] 任意の刺激応答型ペプチド結合切断デバイスの反応速度に与えるアミノ酸配列の影響2009

    • Author(s)
      重永章、山本純、平川寛子、山口圭子、大高章
    • Organizer
      日本薬学会第129回年会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] 蛋白質化学合成を指向した無保護ペプチドフラグメント順次縮合法の開発2009

    • Author(s)
      庄川栄健、津田修吾、重永章、大高章
    • Organizer
      日本薬学会第129回年会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] ペプチド結合切断能を有する側鎖修飾型アスパラギンの開発2008

    • Author(s)
      森下巧、津田修吾、前田奈美、重永章、大高章
    • Organizer
      第47回日本薬学会病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] チオカルボン酸を利用した化学的蛋白質合成法の開発に関する研究2008

    • Author(s)
      住川栄健、津田修吾、重永章、大高章
    • Organizer
      第24回若手化学者のための化学道場
    • Place of Presentation
      徳島
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] 任意の刺激応答型ペプチド結合切断デバイスの開発2008

    • Author(s)
      重永章、西岡直美、山本純、大高章
    • Organizer
      日本ケミカルバイオロジー研究会第3回年会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] Cleavage of peptide bonds for the preparation of functional peptides2008

    • Author(s)
      大高章、重永章、西岡直美、辻大輔、伊藤孝司
    • Organizer
      The 12th Japan-Korea Joint Symposium on Drug Design and Development
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] The application of peptide thioacids to NGL-type sequential condensation of peptide fragments2008

    • Author(s)
      住川栄健、津田修吾、重永章、大高章
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] ペプチド結合切断能を有する光応答型アミノ酸の開発と核一細胞質シャトルペプチドへの応用2008

    • Author(s)
      重永章、辻大輔、西岡直美、山本純、津田修吾、伊藤孝司、大高章
    • Organizer
      日本薬学会第128回年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] 光刺激応答型アミド結合切断反応を利用したケージドセラミドの創製2008

    • Author(s)
      平川寛子、西岡直美、山口圭子、重永章、大高章
    • Organizer
      第47回日本薬学会病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] 光刺激応答型アミド結合切断デバイスを利用したケージドセラミドの創製2008

    • Author(s)
      平川寛子、西岡直美、山口圭子、重永章、大高章
    • Organizer
      創薬懇話会2008
    • Place of Presentation
      徳島
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] 近赤外二光子励起応答型ペプチド結合切断デバイスの開発2008

    • Author(s)
      山本純、住川栄健、西岡直美、重永章、古田寿昭、大高章
    • Organizer
      第47回日本薬学会病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] N-Sアシルシフトを利用した環状ペプチドライブラリー構築の試み2008

    • Author(s)
      前田奈美、津田修吾、重永章、大高章
    • Organizer
      第47回日本薬学会病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] Development of UV irradiation-responsive amino acid with peptide bond cleavage ability and its application to a nucleocytoplasmic shuttle peptide2008

    • Author(s)
      津田修吾、重永章、辻大輔、西岡直美、住川栄健、伊藤孝司、大高章
    • Organizer
      第22回内藤コンファレンス
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] Synthesis of peptide thioester using N-substituted aniline derivatives2008

    • Author(s)
      津田修吾、前田奈美、坂東清美、重永章、大高章
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] Synthesis of fluoroalkene dipeptide isosteres utilizing intramolecular redox reaction catalyzed by N-heterocyclic carbene2008

    • Author(s)
      八巻陽子、重永章、大高章
    • Organizer
      The l2th Japan-Korea Joint Symposium on Drug Design and Development
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] Influence of anamino acid sequence on kinetics of peptide bond cleavage reaction induced byastimulus-responsiveamino acid2008

    • Author(s)
      重永章、西岡直美、山本純、平川寛子、住川栄健、山口圭子、大高章
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] Cleavage of peptide bonds for the preparation of functional peptides2008

    • Author(s)
      大高 章
    • Organizer
      The 12th Japan-Korea Joint Symposium on Drug Design and Development
    • Place of Presentation
      仙台
    • Year and Date
      2008-05-14
    • Data Source
      KAKENHI-PROJECT-19651096
  • [Presentation] Synthesis of fluoroalkene dipeptide isostere utilizing intramolecular redox reaction2008

    • Author(s)
      八巻陽子、重永章、大高章
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] 分子内redox反応を利用したフルオロアルケンジペプチドイソスターの合成2008

    • Author(s)
      八巻陽子、重永章、大高章
    • Organizer
      第34回反応と合成の進歩シンポジウム
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] 人工プロテインスプライシングシステムにおけるペプチド結合切断のための側鎖修飾型アスパラギンの検討2008

    • Author(s)
      津田修吾、前田奈美、重永章、大高章
    • Organizer
      日本薬学会第128回年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] 機能性ペプチドの創製を目指したアミド結合切断法の開発2007

    • Author(s)
      津田修吾、前田奈美、西岡直美、重永章、大高章
    • Organizer
      第46回日本薬学会病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      高知
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] Development of amino acid derivative with amide cleavage ability and its use for the design of shuttle peptides2007

    • Author(s)
      大高章、重永章、辻大輔、西岡直美、津田修吾、伊藤孝司
    • Organizer
      4^<th>International Peptide Symposium in conjunction with 7^<th> Australian Aeptide Conference and 2^<nd> Asia-Facific International Peptide Symposium
    • Place of Presentation
      Queensland, Australia
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] 有機銅試薬を用いたS_N2'型アリル化反応の開発とプロリン型ジペプチドイソスターの合成2007

    • Author(s)
      山口圭子、辻貴志、佐々木義一、重永童、大高章
    • Organizer
      第46回日本薬学会病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      高知
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] Amide bond cleavage for the preparation of functional peptides2007

    • Author(s)
      大高 章
    • Organizer
      Roche Colorado Corporation Peptide Symposium
    • Place of Presentation
      Colorado,USA
    • Year and Date
      2007-09-27
    • Data Source
      KAKENHI-PROJECT-19651096
  • [Presentation] Development of stimulus-responsive amino acid with peptide bond-cleavage ability and it sapplication to a nucleocytoplasmic shuttle peptide2007

    • Author(s)
      重永章、辻大輔、西岡直美、津田修吾、伊藤孝司、大高章
    • Organizer
      第44回ペプチド討論会
    • Place of Presentation
      富山
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] N-ヘテロサイクリックカルベンを利用したフルオロアルケンイソスターの合成2007

    • Author(s)
      八巻陽子、住川栄健、重永章、大高章
    • Organizer
      第46回日本薬学会病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      高知
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] Amide bond cleavage for the preparation of functional peptides2007

    • Author(s)
      大高 章
    • Organizer
      Roche Colorado Corporation Peptide Symposium
    • Place of Presentation
      Colorado,USA
    • Year and Date
      2007-09-27
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] 刺激応答型アミノ酸を利用した核上細胞質シャトルペプチドの開発2007

    • Author(s)
      重永章、辻大輔、津田修吾、伊藤孝司、大高章
    • Organizer
      日本ケミカルバイオロジー研究会第2回年会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] N-ヘテロサイクリックカルベンによる分子内レドックス反応を利用したフルオロアルケンイソスターの合成2007

    • Author(s)
      八巻陽子、重永章、富田健嗣、鳴海哲夫、藤井信孝、大高章
    • Organizer
      日本薬学会第127回年会
    • Place of Presentation
      富山
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] 外部刺激応答型ペプチドプロセシングデバイスの開発2007

    • Author(s)
      重永章、津田修吾、大高章
    • Organizer
      日本薬学会第127回年会
    • Place of Presentation
      富山
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] ペプチド結合切断能を有する刺激応答型アミノ酸の開発と核一細胞質シャトルペプチドへの展開2007

    • Author(s)
      重永章、辻大輔、西岡直美、津田修吾、伊藤孝司、大高章
    • Organizer
      第33回反応と合成の進歩シンポジウム
    • Place of Presentation
      長崎
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] Developlnent of Photo-responsive Self-processing Peptides2006

    • Author(s)
      重永章、新宅沙織、大高章
    • Organizer
      43rd Japanese Peptide Symposium/4th Peptide Engineering Meeting
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] Synthesis of (Z)-alkene cis-Xaa-Pro type dipeptide isosteres using organocopper-mediated anti-SN2'reactions2006

    • Author(s)
      辻貴志、佐々木義一、山口圭子、重永章、藤井信孝、大高章
    • Organizer
      43rd Japanese Peptide Symposium/4th Peptide Engineering Meeting
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] 光刺激応答型ペプチドの開発と速度論的検討2006

    • Author(s)
      重永章、新宅沙織、大高章
    • Organizer
      第7回長井長義記念シンポジウム
    • Place of Presentation
      徳島
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] Development of Photo-triggered Seif-processing Peptides2006

    • Author(s)
      重永章、新宅沙織、大高章
    • Organizer
      ICOB-5&ISCNP-25 IUPAC International Conference on Biodiversity and Natural Products
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] Ragio-and Stereoselective Synthesis of(Z)-Alkene cis-Xaa-Pro Dipeptide Mimetics with Organocopper-mediated Anti-SN2'Reactions2006

    • Author(s)
      佐々木義一、辻貴志、新居田歩、重永章、藤井信孝、大高章
    • Organizer
      29th European Peptide Symposium
    • Place of Presentation
      Gdansk,Poland
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] 外部刺激応答型ペプチドの合成と外部刺激応答能の検討2006

    • Author(s)
      重永章、新宅沙織、大高章
    • Organizer
      第32回反応と合成の進歩シンポジウム
    • Place of Presentation
      広島
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] 有機銅試薬を用いたプロリン型(Z)-アルケンジペプチドイソスターの立体選択的合成・研究2006

    • Author(s)
      辻貴志佐々木義一、山口圭子、重永章、藤井信孝、大高章
    • Organizer
      第45回日本薬学会病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      広島
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] Development of Chemical Devices for Chemical Legations2006

    • Author(s)
      大高章、太田悠介、重永章、藤井信孝
    • Organizer
      The 11^<th> Akabori Conference
    • Place of Presentation
      Kloster Danz, Germany
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] Design, Synthesis and Photo-processing Reaction of Peptides Possessing the External Stimulus-responsive Amino Acid2006

    • Author(s)
      重永章、新宅沙織、大高章
    • Organizer
      29th European Peptide Symposium
    • Place of Presentation
      Gdansk, Poland
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] Preparation of peptide thioaster utilizing S-protected oxazalidinone derived from systeine2006

    • Author(s)
      大高章、太田悠介、重永章、藤井信孝
    • Organizer
      The 11th Korea-Japan Joint Symposium On Drug Design and Development
    • Place of Presentation
      Jeju Island, Korea
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] Synthesis of (Z)-alkane-containing Pro dipeptide isosteres corresponding to cis-prolyl peptides2006

    • Author(s)
      佐々木義一、新居田歩、辻貴志、重永章、藤井信孝、大高章
    • Organizer
      The 11th Korea-Japan Joint Symposium On Drug Design and Development
    • Place of Presentation
      Jeju Island, Korea
    • Data Source
      KAKENHI-PROJECT-18390006
  • [Presentation] Chemical thioester synthesis applicable to naturally occurring peptide sequence

    • Author(s)
      A. Otaka, Y. Tsuda, A. Shigenaga
    • Organizer
      15th Akabori Conference Japanese-German Symposium on Peptide Science,
    • Place of Presentation
      Best Western Premier Bellevue Rheinhotel (ボッパルド, ドイツ)
    • Year and Date
      2014-09-08 – 2014-09-09
    • Data Source
      KAKENHI-PROJECT-24390026
  • [Presentation] One-pot chemical synthesis of CXCL14 using N-sulfanylethylanilide peptide

    • Author(s)
      Kohei Tsuji, Kohei Sato, Ken Sakamoto, Kosuke Tanegashima, Akira Shigenaga, Tsubasa Inokuma, Takahiko Hara and Akira Otaka
    • Organizer
      51th The Japanese Peptide Society
    • Place of Presentation
      徳島大学(徳島県徳島市)
    • Year and Date
      2014-10-22 – 2014-10-24
    • Data Source
      KAKENHI-PROJECT-25670058
  • [Presentation] アルギニン変異apoA-Iフラグメントのアミロイド線維形成性

    • Author(s)
      三河志穂,水口智晴,辻耕平,馬場照彦,重永章,大高章,斎藤博幸
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸サンボーホール(兵庫県神戸市)
    • Year and Date
      2015-03-26 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-25293006
  • [Presentation] Development of N-glycosylated asparagine ligation and its application to total chemical synthesis of GM2 activator protein

    • Author(s)
      Kohei Sato, Keisuke Kitakaze, Ken Sakamoto, Akira Shigenaga, Tsubasa Inokuma, Daisuke Tsuji, Kouji Itou and Akira Otaka
    • Organizer
      51th The Japanese Peptide Society
    • Place of Presentation
      徳島大学(徳島県徳島市)
    • Year and Date
      2014-10-22 – 2014-10-24
    • Data Source
      KAKENHI-PROJECT-25670058
  • [Presentation] Chemical protein synthesis utilizing SEAlide technology that is potentially applicable to incorporation of artificial amino acids into proteins for their functional control

    • Author(s)
      Akira Shigenaga, Kohei Sato, Tsubasa Inokuma and Akira Otaka
    • Organizer
      The 2nd International Symposium on Fusion Materials Program
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2014-11-02 – 2014-11-04
    • Data Source
      KAKENHI-PROJECT-24390026
  • [Presentation] 固-液融合型ペプチド合成法を用いた架橋ペプチド効率的合成法の開発

    • Author(s)
      粟飯原 圭佑, 小宮 千明, 重永 章, 猪熊 翼, 高橋 大輔, 大髙 章
    • Organizer
      第40回反応と合成の進歩シンポジウム
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2014-11-10 – 2014-11-11
    • Data Source
      KAKENHI-PROJECT-24390026
  • [Presentation] インテインに学ぶ標的タンパク質研究手法の開発

    • Author(s)
      大高 章、重永 章
    • Organizer
      日本薬学会第134回年会
    • Place of Presentation
      熊本大学(熊本県)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23390026
  • [Presentation] GM2活性化タンパク質誘導体の第二世代化学合成法の開発研究

    • Author(s)
      中村 太寛, 重永 章, 佐藤 浩平, 津田 雄介, 坂本 健, 猪熊 翼, 大髙 章
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学(兵庫県神戸市)
    • Year and Date
      2015-03-25 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-24390026
  • [Presentation] Synthetic study of GM2 activator protein using N-sulfanylethylanilide peptide

    • Author(s)
      K. Sato, K. Kitakaze, K. Sakamoto, A. Shigenaga, D. Tsuji, Kouji Itou, A. Otaka
    • Organizer
      The 33rd European Peptide Symposium
    • Place of Presentation
      国立文化パレス(ソフィア, ブルガリア)
    • Year and Date
      2014-09-02 – 2014-09-04
    • Data Source
      KAKENHI-PROJECT-25670058
  • [Presentation] 新規タンパク質チオエステル調製法の開発

    • Author(s)
      津田 雄介, 重永 章, 傳田 将也, 佐藤 浩平, 北風 圭介, 中村 太寛, 猪熊 翼, 伊藤 孝司, 大髙 章
    • Organizer
      第53回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      広島国際会議場(広島県広島市)
    • Year and Date
      2014-11-08 – 2014-11-09
    • Data Source
      KAKENHI-PROJECT-25670058
  • [Presentation] プロテインスプライシング模倣型ペプチド結合切断デバイスの開発研究

    • Author(s)
      小宮 千明, 粟飯原 圭佑, 猪熊 翼, 重永 章, 大髙 章
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学(兵庫県神戸市)
    • Year and Date
      2015-03-25 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-24390026
  • [Presentation] Dimerized CXCL14 C-terminal regions inhibit CXCL12-CXCR4 signaling axis

    • Author(s)
      K. Tsuji, K. Tanegashima, Akira Shigenaga, T. Hara, A. Otaka
    • Organizer
      The 33rd European Peptide Symposium
    • Place of Presentation
      国立文化パレス(ソフィア, ブルガリア)
    • Year and Date
      2014-09-02 – 2014-09-04
    • Data Source
      KAKENHI-PROJECT-25670058
  • [Presentation] オレフィンメタセシスを用いた架橋ペプチド効率的合成法の開発

    • Author(s)
      粟飯原 圭佑, 小宮 千明, 重永 章, 猪熊 翼, 高橋 大輔, 大髙 章
    • Organizer
      創薬懇話会2014
    • Place of Presentation
      長良川温泉ホテルパーク(岐阜県岐阜市)
    • Year and Date
      2014-07-10 – 2014-07-11
    • Data Source
      KAKENHI-PROJECT-24390026
  • [Presentation] 天然アミノ酸配列に適用可能な新規タンパク質チオエステル合成法の開発

    • Author(s)
      津田 雄介, 重永 章, 佐藤 浩平, 中村 太寛, 北風 圭介, 猪熊 翼, 伊藤 孝司, 大髙 章
    • Organizer
      日本ケミカルバイオロジー学会第9回年会
    • Place of Presentation
      大阪大学(大阪府豊中市)
    • Year and Date
      2014-06-11 – 2014-06-13
    • Data Source
      KAKENHI-PROJECT-25670058
  • [Presentation] M6P修飾型GM2APの合成検討

    • Author(s)
      成瀬 公人, 佐藤 浩平, 坂本 健, 猪熊 翼, 重永 章, 大髙 章
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学(兵庫県神戸市)
    • Year and Date
      2015-03-25 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-25670058
  • [Presentation] Development of N-glycosylated asparagine ligation and its application to total chemical synthesis of GM2 activator protein

    • Author(s)
      Kohei Sato, Keisuke Kitakaze, Ken Sakamoto, Akira Shigenaga, Tsubasa Inokuma, Daisuke Tsuji, Kouji Itou and Akira Otaka
    • Organizer
      51th The Japanese Peptide Society
    • Place of Presentation
      徳島大学(徳島県徳島市)
    • Year and Date
      2014-10-22 – 2014-10-24
    • Data Source
      KAKENHI-PROJECT-24390026
  • [Presentation] 新規タンパク質チオエステル調製法の開発

    • Author(s)
      津田 雄介, 重永 章, 傳田 将也, 佐藤 浩平, 北風 圭介, 中村 太寛, 猪熊 翼, 伊藤 孝司, 大髙 章
    • Organizer
      第53回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      広島国際会議場(広島県広島市)
    • Year and Date
      2014-11-08 – 2014-11-09
    • Data Source
      KAKENHI-PROJECT-24390026
  • [Presentation] Chemical thioester synthesis applicable to naturally occurring peptide sequence

    • Author(s)
      A. Otaka, Y. Tsuda, A. Shigenaga
    • Organizer
      15th Akabori Conference Japanese-German Symposium on Peptide Science,
    • Place of Presentation
      Best Western Premier Bellevue Rheinhotel (ボッパルド, ドイツ)
    • Year and Date
      2014-09-08 – 2014-09-09
    • Data Source
      KAKENHI-PROJECT-25670058
  • [Presentation] 細胞内シグナル伝達機構解明を指向したケージド非水解性リン酸化アミノ酸の合成とその機能評価

    • Author(s)
      戎野 紘司, 傳田 将也, 小倉 圭司, 猪熊 翼, 重永 章, 大髙 章
    • Organizer
      第40回反応と合成の進歩シンポジウム
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2014-11-10 – 2014-11-11
    • Data Source
      KAKENHI-PROJECT-24390026
  • [Presentation] 細胞内シグナル伝達機構解明を指向したケージド非水解性リン酸化アミノ酸の合成とその機能評価

    • Author(s)
      戎野 紘司, 傳田 将也, 小倉 圭司, 猪熊 翼, 重永 章, 大髙 章
    • Organizer
      第40回反応と合成の進歩シンポジウム
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2014-11-10 – 2014-11-11
    • Data Source
      KAKENHI-PROJECT-25670058
  • [Presentation] ペプチドチオエステル調製のためのクマリン型補助基の開発

    • Author(s)
      江藤 三弘, 傳田 将也, 佐藤 浩平, 坂本 健, 猪熊 翼, 重永 章, 大髙 章
    • Organizer
      第53回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      広島国際会議場(広島県広島市)
    • Year and Date
      2014-11-08 – 2014-11-09
    • Data Source
      KAKENHI-PROJECT-24390026
  • [Presentation] 固-液融合型ペプチド合成法を用いた架橋ペプチド効率的合成法の開発

    • Author(s)
      粟飯原 圭佑, 小宮 千明, 重永 章, 猪熊 翼, 高橋 大輔, 大髙 章
    • Organizer
      第40回反応と合成の進歩シンポジウム
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2014-11-10 – 2014-11-11
    • Data Source
      KAKENHI-PROJECT-25670058
  • [Presentation] One-pot chemical synthesis of CXCL14 using N-sulfanylethylanilide peptide

    • Author(s)
      Kohei Tsuji, Kohei Sato, Ken Sakamoto, Kosuke Tanegashima, Akira Shigenaga, Tsubasa Inokuma, Takahiko Hara and Akira Otaka
    • Organizer
      51th The Japanese Peptide Society
    • Place of Presentation
      徳島大学(徳島県徳島市)
    • Year and Date
      2014-10-22 – 2014-10-24
    • Data Source
      KAKENHI-PROJECT-24390026
  • [Presentation] プロテインスプライシング模倣型ペプチド結合切断デバイスの開発研究

    • Author(s)
      小宮 千明, 粟飯原 圭佑, 猪熊 翼, 重永 章, 大髙 章
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学(兵庫県神戸市)
    • Year and Date
      2015-03-25 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-25670058
  • [Presentation] ペプチドチオエステル調製のためのクマリン型補助基の開発

    • Author(s)
      江藤 三弘, 傳田 将也, 佐藤 浩平, 坂本 健, 猪熊 翼, 重永 章, 大髙 章
    • Organizer
      第53回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      広島国際会議場(広島県広島市)
    • Year and Date
      2014-11-08 – 2014-11-09
    • Data Source
      KAKENHI-PROJECT-25670058
  • [Presentation] 天然アミノ酸配列に適用可能な新規タンパク質チオエステル合成法の開発

    • Author(s)
      津田 雄介, 重永 章, 佐藤 浩平, 中村 太寛, 北風 圭介, 猪熊 翼, 伊藤 孝司, 大髙 章
    • Organizer
      日本ケミカルバイオロジー学会第9回年会
    • Place of Presentation
      大阪大学(大阪府豊中市)
    • Year and Date
      2014-06-11 – 2014-06-13
    • Data Source
      KAKENHI-PROJECT-24390026
  • [Presentation] オレフィンメタセシスを用いた架橋ペプチド効率的合成法の開発

    • Author(s)
      粟飯原 圭佑, 小宮 千明, 重永 章, 猪熊 翼, 高橋 大輔, 大髙 章
    • Organizer
      創薬懇話会2014
    • Place of Presentation
      長良川温泉ホテルパーク(岐阜県岐阜市)
    • Year and Date
      2014-07-10 – 2014-07-11
    • Data Source
      KAKENHI-PROJECT-25670058
  • [Presentation] GM2活性化タンパク質誘導体の第二世代化学合成法の開発研究

    • Author(s)
      中村 太寛, 重永 章, 佐藤 浩平, 津田 雄介, 坂本 健, 猪熊 翼, 大髙 章
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学(兵庫県神戸市)
    • Year and Date
      2015-03-25 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-25670058
  • [Presentation] 過酸化水素応答型ペプチド結合切断デバイスの開発研究

    • Author(s)
      北 未来, 山本 純, 戎野 紘司, 小宮 千明, 宮本 理人, 土屋 浩一郎, 重永 章, 大髙 章
    • Organizer
      日本ケミカルバイオロジー学会第9回年会
    • Place of Presentation
      大阪大学(大阪府豊中市)
    • Year and Date
      2014-06-11 – 2014-06-13
    • Data Source
      KAKENHI-PROJECT-25670058
  • [Presentation] M6P修飾型GM2APの合成検討

    • Author(s)
      成瀬 公人, 佐藤 浩平, 坂本 健, 猪熊 翼, 重永 章, 大髙 章
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学(兵庫県神戸市)
    • Year and Date
      2015-03-25 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-24390026
  • [Presentation] DESIGN OF NANODISC SCAFFOLD PEPTIDE (NSP)

    • Author(s)
      假屋園大和, 新村航,辻耕平,重永章,大高章,斎藤博幸
    • Organizer
      第51回ペプチド討論会
    • Place of Presentation
      徳島大学(徳島県徳島市)
    • Year and Date
      2014-10-22 – 2014-10-24
    • Data Source
      KAKENHI-PROJECT-25293006
  • [Presentation] Chemical protein synthesis utilizing SEAlide technology that is potentially applicable to incorporation of artificial amino acids into proteins for their functional control

    • Author(s)
      Akira Shigenaga, Kohei Sato, Tsubasa Inokuma and Akira Otaka
    • Organizer
      The 2nd International Symposium on Fusion Materials Program
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2014-11-02 – 2014-11-04
    • Data Source
      KAKENHI-PROJECT-25670058
  • [Presentation] 過酸化水素応答型ペプチド結合切断デバイスの開発研究

    • Author(s)
      北 未来, 山本 純, 戎野 紘司, 小宮 千明, 宮本 理人, 土屋 浩一郎, 重永 章, 大髙 章
    • Organizer
      日本ケミカルバイオロジー学会第9回年会
    • Place of Presentation
      大阪大学(大阪府豊中市)
    • Year and Date
      2014-06-11 – 2014-06-13
    • Data Source
      KAKENHI-PROJECT-24390026
  • [Presentation] Dimerized CXCL14 C-terminal regions inhibit CXCL12-CXCR4 signaling axis

    • Author(s)
      K. Tsuji, K. Tanegashima, Akira Shigenaga, T. Hara, A. Otaka
    • Organizer
      The 33rd European Peptide Symposium
    • Place of Presentation
      国立文化パレス(ソフィア, ブルガリア)
    • Year and Date
      2014-09-02 – 2014-09-04
    • Data Source
      KAKENHI-PROJECT-24390026
  • [Presentation] Synthetic study of GM2 activator protein using N-sulfanylethylanilide peptide

    • Author(s)
      K. Sato, K. Kitakaze, K. Sakamoto, A. Shigenaga, D. Tsuji, Kouji Itou, A. Otaka
    • Organizer
      The 33rd European Peptide Symposium
    • Place of Presentation
      国立文化パレス(ソフィア, ブルガリア)
    • Year and Date
      2014-09-02 – 2014-09-04
    • Data Source
      KAKENHI-PROJECT-24390026
  • 1.  TAMAMURA Hirokazu (80217182)
    # of Collaborated Projects: 13 results
    # of Collaborated Products: 0 results
  • 2.  FUJII Nobutaka (60109014)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 3 results
  • 3.  IBUKA Toshiroh (80025692)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 4.  SHIGENAGA Akira (10423394)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 129 results
  • 5.  ITOH Kohji (00184656)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 12 results
  • 6.  HOSOTANI Ryo (00139908)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  KATAGIRI Toyomasa (60291895)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 8.  YOSHIMARU Tetsuro (80424729)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 9.  MATSUSHITA Yosuke (70634450)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 10.  ONO Masaya (00270900)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  MUZUGUCHI Kenji (50450896)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  河野 通明 (00027335)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  傳田 将也 (00813891)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 14.  SHISHIDO Kozo (20006349)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  TSUJI Daisuke (00423400)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 16.  FUNAKOSHI Susumu (10135593)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  YAMAMOTO Yoshinori (60029519)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  YAMAMOTO Naoki (00094053)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  Saito Hiroyuki (60300919)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 17 results
  • 20.  AKAJI Kenichi (60142296)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 21.  OKAMURA Emiko (00160705)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  KOBAYASHI Norihiro (90205477)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 23.  KITAGAWA Shuji (00108911)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  MICHIKAWA Makoto (40270912)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  INOKUMA Tsubasa (40541272)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 16 results
  • 26.  井上 謙一郎 (40025713)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  片岡 貞 (00082975)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  佐藤 仁彦 (00240945)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  土井 隆一郎 (20301236)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  真板 宣夫 (00404046)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  広川 貴次 (20357867)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 32.  原 孝彦 (80280949)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 17 results
  • 33.  笠原 二郎 (10295131)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  長尾 耕治郎 (40587325)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 35.  喜屋武 龍二 (00910150)
    # of Collaborated Projects: 1 results
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  • 36.  吉川 治孝 (60709567)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  稲垣 暢也 (30241954)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 38.  原田 範雄 (50530169)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 39.  山根 俊介 (90582156)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 40.  藤野 裕道 (40401004)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 41.  TANAKA Hirokazu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 42.  黒川 勉
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 43.  西村 紀
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 44.  杉本 幸彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 45.  山田 健一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 46.  谷野 圭持
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 47.  三好 康雄
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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