Kubo Shinichiro 久保紳一郎

… Alternative Names

KUBO Shinichiro 久保紳一郎

KUBO Shinitiro 久保紳一郎

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Researcher Number	20327795
Other IDs
Affiliation (Current)	2025: 順天堂大学, 医学部, 非常勤講師
Affiliation (based on the past Project Information) *help	2016 – 2017: 順天堂大学, 医学部, 非常勤講師 2015: 順天堂大学, 医学部, 准教授 2010: Juntendo University, 医学研究科, 准教授 2006 – 2010: Juntendo Medical, Associate Professor, 医学部, 准教授 2006: 順天堂大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Neurology Except Principal Investigator Neurology / Biological Sciences
Keywords	Principal Investigator DJ-1 / Parkin / PINK1 / LRRK2 / lipid rafts / パーキンソン病 / GBA / 細胞膜 / 脂質 / アルファシヌクレイン … More / レビー小体 / Famililal Parkinson's disease / シナプス小胞 / ゴルジ体 / 細胞内局在 / Lipid rafts / 遺伝性パーキンソン病 / 膜輸送 / 家族性パーキンソン病 … More Except Principal Investigator DJ-1 / PINK1 / 遺伝性パーキンソン病 / Parkin / 共通機構 / パーキンソン病 / Knock-out mice / mitochondrial dysfunction / 24-kDa subunit / ubiquitin-proteasome / Familial Parkinson's disease / Parkinson's disease / LRRK2 / ドパミンキノン体 / 14-3-3η / アグリゾーム / duplication / alpha-synuclein / パーキン / 家族性パーキンソン病 / 24-Daサブユニット / ノックアウトマウス / ミトコンドリア機能低下 / 24-kDaサブユニット / ユビキチン・プロテアソーム系 / 学習能力 / 蛋白分解系 / オートファジー / 品質管理 / Mitophagy / ミトコンドリア / CCCP / 連鎖解析 / 常染色体劣性晩発性パーキンソン病 / ユビキチン化 / ATP132 / autophagy-lysosomal path& / ミトコンドリア機能 / 劣性遺伝性パーキンソン病 / 新規原因遺伝子 Less

Elucidation of a mechanism of Lewy body formationPrincipal Investigator
- Principal Investigator
  
  KUBO Shinichiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
To elucidate the pathogenesis of Parkinson' s disease and to develop a new therapy for the disease
- Principal Investigator
  
  HATTORI Nobutaka
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Juntendo University
Analyses of responsible protein for familial Parkinson's disease in lipid rafts.Principal Investigator
- Principal Investigator
  
  KUBO Shinichiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
Identification of a common pathway among gene products for familial Parkinson's disease and screening for a novel causative gene for
- Principal Investigator
  
  HATTORI Nobutaka
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
Functional analyses of the responsible proteins for familial Parkinson's disease in association with lipid raftsPrincipal Investigator
- Principal Investigator
  
  KUBO Shin-ichiro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
The analysis of Familial Parkinson's disease gene products and the research for identification of a novel Familial Parkinson's disease gene
- Principal Investigator
  
  HATTORI Nobutaka
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  JUNTENDO UNIVERSITY

All 2009 2008 2007 2006

All Journal Article Presentation Book

[Book] パーキンソン病Q&A(服部信孝)(Q2.パーキンソン病の原因は?)2009
- Author(s)
  久保紳一郎
- Publisher
  日本医事新報社,東京
- Data Source
  KAKENHI-PROJECT-20591010
[Book] パーキンソン病診療Q&A110(水野美邦)(Q67. 1日300mg以上の塩酸アマンタジンがジスキネジアを抑制するといわれますが、同じ薬物が維持量の違いによってパーキンソニズムに効いたり、ジスキネジアに効いたりする機序は何なのでしょうか?)2009
- Author(s)
  久保紳一郎
- Publisher
  中外医学社,東京
- Data Source
  KAKENHI-PROJECT-20591010
[Book] 医学のあゆみ(ここまでわかったパーキンソン病研究医歯薬出版別冊)2008
- Author(s)
  河尻澄宏、久保紳一郎
- Total Pages
  100
- Data Source
  KAKENHI-PROJECT-20591010
[Book] 別冊「医学のあゆみ」ここまでわかったパーキンソン病研究2008
- Author(s)
  河尻澄宏, 久保紳一郎
- Total Pages
  100
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-20591010
[Book] 最新医学・別冊新しい診断と治療のABC2006
- Author(s)
  久保紳一郎
- Publisher
  最新医学社
- Data Source
  KAKENHI-PROJECT-18590956
[Book] 最新医学、別冊新しい診断と治療のABC2006
- Author(s)
  久保紳一郎
- Publisher
  最新医学社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590956
[Book] 塩酸アマンタジン、抗コリン薬の効果と安全性に関するエビデンス。2006
- Author(s)
  久保紳一郎
- Total Pages
  12
- Publisher
  最新医学社
- Data Source
  KAKENHI-PROJECT-18590956
[Journal Article] Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.2009
- Author(s)
  Satake W, Nakabayashi Y, Mizuta I, Hirota Y, Ito C, Kubo M, Kawaguchi T, Tsunoda T, Watanabe M, Takeda A, Tomiyama H, Nakashima K, Hasegawa K, Obata F, Yoshikawa T, Kawakami H, Sakoda S, Yamamoto M, Hattori N, Murata M, Nakamura Y, Toda T
- Journal Title
  
  Nat Genet 41
  
  Pages: 1303-1307
- Data Source
  KAKENHI-PROJECT-20023028
[Journal Article] Mutation analysis for DJ-1 in sporadic and familial parkinsonism: Screening strategy in parkinsonism.2009
- Author(s)
  Tomiyama H, Li Y, Yoshino H, Mizuno Y, Kubo S, Toda T, Hattori N
- Journal Title
  
  Neurosci Lett 455
  
  Pages: 159-161
- Data Source
  KAKENHI-PROJECT-20023028
[Journal Article]2009
- Author(s)
  久保紳一郎
- Journal Title
  
  パーキンソン病診療Q&A110(中外医学社)
  
  Pages: 205-209
- Data Source
  KAKENHI-PROJECT-20591010
[Journal Article] Parkin stabilizes PINK1 through direct interaction.2009
- Author(s)
  Shiba K, Arai T, Sato S, Kubo S, Ohba Y, Mizuno Y, Hattori N
- Journal Title
  
  Biochem Biophys Res Commun 383
  
  Pages: 331-335
- Data Source
  KAKENHI-PROJECT-20591010
[Journal Article] Effective control of catatonia in Parkinson's disease by electroconvulsive therapy : a case report.2009
- Author(s)
  Kamigaichi R, Kubo S, Ishikawa K, Yokoyama K, Ogaki K, Usui C, Hatta K, Arai H, Mochizuki H, Hattori N
- Journal Title
  
  Eur J Neurol 16
- Data Source
  KAKENHI-PROJECT-20591010
[Journal Article] Unmet needs of patients with Parkinson's disease : interview survey of patients and caregivers.2009
- Author(s)
  Hatano T, Kubo S, Shimo Y, Nishioka K, Hattori N
- Journal Title
  
  J Int Med Res 37
  
  Pages: 717-726
- Data Source
  KAKENHI-PROJECT-20591010
[Journal Article] Mutation analysis for DJ-1 in sporadic and familial parkinsonism : screening strategy in parkinsonism.2009
- Author(s)
  Tomiyama H, Li Y, Yoshino H, Mizuno Y, Kubo S, Toda T, Hattori N
- Journal Title
  
  Neurosci Lett 455
  
  Pages: 159-161
- Data Source
  KAKENHI-PROJECT-20591010
[Journal Article] Parkin stabilizes PINK1 through direct interaction.2009
- Author(s)
  Shiba K, Arai T, Sato S, Kubo S, Ohba Y, Mizuno Y, Hattori N
- Journal Title
  
  Biochem Biophys Res Commun 383
  
  Pages: 331-335
- Data Source
  KAKENHI-PROJECT-20023028
[Journal Article]2009
- Author(s)
  久保紳一郎
- Journal Title
  
  パーキンソン病Q&A110(日本医事新報社)
  
  Pages: 5-8
- Data Source
  KAKENHI-PROJECT-20591010
[Journal Article] LRRK2 P755L variant in sporadic Parkinson's disease.2008
- Author(s)
  Tomiyama H, Mizuta I, Li Y, Funayama M, Yoshino H, Li L, Murata M, Yamamoto M, Kubo S, Mizuno Y, Toda T, Hattori N
- Journal Title
  
  J Hum Genet 53
  
  Pages: 1012-1015
- NAID
  10025584966
- Data Source
  KAKENHI-PROJECT-20591010
[Journal Article] Visual impairment in Parkinson's disease treated with amantadine : Case report and review of the literature2008
- Author(s)
  Kubo, S., Iwatake, A., Ebihara, N., Murakami, A., Hattori, N
- Journal Title
  
  Parkinsonism Relat Disord 14
  
  Pages: 166-169
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590956
[Journal Article] LRRK2 P755L variant in sporadic Parkinson's disease2008
- Author(s)
  Tomiyama H, Mizuta I, Li Y, Funayama M, Yoshino H, Li L, Murata M, Yamamoto M, Kubo S, Mizuno Y, Toda T, Hattori N
- Journal Title
  
  J Hum Genet 53
  
  Pages: 1012-5
- NAID
  10025584966
- Data Source
  KAKENHI-PROJECT-19390244
[Journal Article] Progress in the pathogenesis and genetics of Parkinson's disease2008
- Author(s)
  Mizuno Y, Hattori N, Kubo SI, Sato S, Nishioka K, Hatano T, Tomiyama H, Funayama M, Machida Y, Mochizuki H. Review
- Journal Title
  
  Philos Trans R Soc Lond B Biol Sci 27
  
  Pages: 2215-2227
- Data Source
  KAKENHI-PROJECT-19390244
[Journal Article] Visual impairment in Parkinson's disease treated with amantadine:Case report and review of the literature2008
- Author(s)
  Kubo S
- Journal Title
  
  Parkinsonism Relat Disord 14
  
  Pages: 166-169
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590956
[Journal Article] Familial Parkinsonism with digenic parkin and PINK1 mutations.2008
- Author(s)
  Funayama M, Li Y, Tsoi TH, Lam CW, Ohi T, Yazawa S, Uyama E, Djaldetti R, Melamed E, Yoshino H, Imamichi Y, Takashima H, Nishioka K, Sato K, Tomiyama H, Kubo S, Mizuno Y, Hattori N
- Journal Title
  
  Mov Disord 23
  
  Pages: 1461-1465
- Data Source
  KAKENHI-PROJECT-20591010
[Journal Article] Visual impairment in Parkinson's disease treated with amanta dine : Case report and review of the literature2008
- Author(s)
  Kubo S
- Journal Title
  
  Parkinsonism Relat Disord 14
  
  Pages: 166-169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591010
[Journal Article] Mutation analyses in amyotrophic lateral sclerosis/parkinsonism-dementia complex of Kii, Japan2008
- Author(s)
  Tomiyama H, Kokubo Y, Sasaki R, Li Y, Imamichi Y, Funayama M, Mizuno Y, Hattori N, Kuzuhara S
- Journal Title
  
  Mov Disord 23
  
  Pages: 2344-2348
- Data Source
  KAKENHI-PROJECT-19390244
[Journal Article] Familial parkinsonism with digenic parkin and PINK1 mutations2008
- Author(s)
  Funayama M, Li Y, Tsoi TH, Lam CW, Ohi T, Yazawa S, Uyama E, Djaldetti R, Melamed E, Yoshino H, Imamichi Y, Takashima H, Nishioka K, Sato K, Tomiyama H, Kubo S, MD, Mizuno Y, Hattori N
- Journal Title
  
  Mov Disord 65
  
  Pages: 802-808
- Data Source
  KAKENHI-PROJECT-19390244
[Journal Article] Visual impairment in Parkinson's disease treated with amantadine : Case report and review of the literature.2008
- Author(s)
  Kubo S, Iwatake A, Ebihara N, Murakami A, Hattori N
- Journal Title
  
  Parkinsonism Relat Disord 14
  
  Pages: 166-169
- Data Source
  KAKENHI-PROJECT-20591010
[Journal Article] Visual impairment in Parkinson's disease treated with amantadine : case report and review of the literature2008
- Author(s)
  Kubo S, Iwatake A, Ebihara N, Murakami A, Hattori N
- Journal Title
  
  Parkinsonism Relat Disord 14(2)
  
  Pages: 166-9
- Data Source
  KAKENHI-PROJECT-19390244
[Journal Article] Leucine-rich repeat kinase 2 associates with lipid rafts2007
- Author(s)
  Hatano T, Kubo SI, Imai S, Maeda M, Ishikawa K, Mizuno Y, Hattori N
- Journal Title
  
  Hum Mol Genet 16
  
  Pages: 678-690
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390256
[Journal Article] Leucine-rich repeat kinase 2 associates with lipid rafts2007
- Author(s)
  Hatano T, Kubo S, Imai S, Maeda M, Ishikawa K, Mizuno Y, Hattori N
- Journal Title
  
  Hum Mol Genet 16
  
  Pages: 678-90
- Data Source
  KAKENHI-PROJECT-19390244
[Journal Article] Leucine-rich repeat kinase 2 associates with lipid rafts2007
- Author(s)
  Hatano, T., Kubo, S., Imai, S., Maeda, M., Ishikawa, K., Mizuno, Y., Hattori, N
- Journal Title
  
  Hum Mol Genet 16
  
  Pages: 678-690
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590956
[Journal Article] Neuropsychiatric and cognitive features in autosomal-recessive early parkinsonism due to PINK1 mutations2007
- Author(s)
  Hatano T, Kubo SI, Imai S, Maeda M, Ishikawa K, Mizuno Y, Hattori N
- Journal Title
  
  Hum Mol Genet Mar 6 (epub ahead of print)
- Data Source
  KAKENHI-PROJECT-17390256
[Journal Article] Recessive Parkinson's disease2006
- Author(s)
  Kubo S
- Journal Title
  
  Mov Disord 21
  
  Pages: 885-893
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590956
[Journal Article] Recessive Parkinson's disease2006
- Author(s)
  Kubo, S., Hattori, N., Mizuno, Y
- Journal Title
  
  Mov Disord 21
  
  Pages: 885-893
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590956
[Journal Article] Molecular mechanisms of nigral neurodegeneration in Park2 and regulation of parkin protein by other proteins2006
- Author(s)
  Hattori, N., Machida, Y., Sato, S., Noda, K., Iijima-Kitami, M., Kubo, S., Mizuno, Y
- Journal Title
  
  J Neural Transm 70
  
  Pages: 205-208
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590956
[Journal Article] Recessive Parkinson's disease2006
- Author(s)
  Kubo S, Hattori N, Mizuno Y
- Journal Title
  
  Mov Disord 21
  
  Pages: 885-893
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390256
[Journal Article] Clinicogenetic study of mutations in LRRK2 exon 41 in Parkinson's disease patients from 18 countries2006
- Author(s)
  Tomiyama H, Li Y, Funayama M, Hasegawa K, Yoshino H, Kubo S, Sato K, Hattori T, Lu C-S, Inzelberg R, Djaldetti R, Melamed E, Amouri R, Gouider-Khouja N, Hentati F, Hatano Y, Wang M, Imamichi Y, Mizoguchi K, Miyajima H, Obata F, Toda T, Farrer MJ, Mizuno Y, Hattori N
- Journal Title
  
  Mov Disord 21
  
  Pages: 1102-1108
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390256
[Journal Article] Recessive Parkinson's disease.2006
- Author(s)
  Kubo S et al.
- Journal Title
  
  Mov Disord. 21
  
  Pages: 885-893
- Data Source
  KAKENHI-PROJECT-18590956
[Journal Article] Clinicogenetic study of mutations in LRRK2 exon 41 in Parkinson's disease patients from 18 countries2006
- Author(s)
  Tomiyama, H., Li, Y., Funayama, M., Hasegawa, K., Yoshino, H., Kubo, S., Sato, K., Hattori, T., Lu, CS., Inzelberg, R., Djaldetti, R., Melamed, E., Amouri, R., Gouider-Khouja, N., Hentati, F., Hatano, Y., Wang, M., Imamichi, Y., Mizoguchi, K., Miyajima, H., Obata, F., Toda, T., Farrer, MJ., Mizuno, Y., Hattori, N
- Journal Title
  
  Mov Disord 21
  
  Pages: 1102-1108
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590956
[Journal Article] Recessive Parkinson's disease2006
- Author(s)
  Kubo S, Hattori N, Mizuno Y
- Journal Title
  
  Mov Disord. 21
  
  Pages: 885-893
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390256
[Presentation] Autosomal recessive late onset parkinsonismの原因遺伝子探索2008
- Author(s)
  舩山学, 吉野浩代, 今道洋子, 李元哲, 李林, 増田浩美, 板谷昌子, 高梨雅史, 高嶋博, 松浦英治, 有村公良, 野元三治, 富山弘幸, 久保紳一郎, 水野美邦, 服部信孝
- Organizer
  第2回Movement Disorder Society, Japan学術集会
- Place of Presentation
  京都
- Year and Date
  2008-10-04
- Data Source
  KAKENHI-PROJECT-19390244
[Presentation] LRRK2 associates with lipid rafts2007
- Author(s)
  Kubo S
- Organizer
  The Movement Disorder Society
- Place of Presentation
  Istanbul
- Year and Date
  2007-06-04
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590956

1. HATTORI Nobutaka (80218510)

# of Collaborated Projects: 5 results

# of Collaborated Products: 27 results
2. SATO Shigeto (00445537)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. HIRASAWA Motoyuki (90338393)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. SATO Kenichi (00276461)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. TOMIYAMA Hiroyuki (20515069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
6. IWAI Kazyhiro (60252459)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SHIOMO Yashushi (70286714)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. HATANO Taku (60338390)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. FUNAYAMA Manabu (70468578)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 町田裕 (90317470)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 水野美邦 (30049043)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
12. SAKATA Shinithi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kubo Shinichiro 久保 紳一郎

KUBO Shinichiro 久保 紳一郎

KUBO Shinitiro 久保 紳一郎

Research Projects

Research Products

Co-Researchers

Elucidation of a mechanism of Lewy body formationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

To elucidate the pathogenesis of Parkinson' s disease and to develop a new therapy for the disease

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analyses of responsible protein for familial Parkinson's disease in lipid rafts.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of a common pathway among gene products for familial Parkinson's disease and screening for a novel causative gene for

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analyses of the responsible proteins for familial Parkinson's disease in association with lipid raftsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The analysis of Familial Parkinson's disease gene products and the research for identification of a novel Familial Parkinson's disease gene

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] パーキンソン病Q&A(服部信孝)(Q2.パーキンソン病の原因は?)2009

Author(s)

Publisher

Data Source

Author(s)

Publisher

Data Source

[Book] 医学のあゆみ(ここまでわかったパーキンソン病研究 医歯薬出版別冊)2008

Author(s)

Total Pages

Data Source

[Book] 別冊「医学のあゆみ」ここまでわかったパーキンソン病研究2008

Author(s)

Total Pages

Publisher

Data Source

[Book] 最新医学・別冊新しい診断と治療のABC2006

Author(s)

Publisher

Data Source

[Book] 最新医学、別冊 新しい診断と治療のABC2006

Author(s)

Publisher

Description

Data Source

[Book] 塩酸アマンタジン、抗コリン薬の効果と安全性に関するエビデンス。2006

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.2009

Author(s)

Journal Title

Data Source

[Journal Article] Mutation analysis for DJ-1 in sporadic and familial parkinsonism: Screening strategy in parkinsonism.2009

Author(s)

Journal Title

Data Source

Kubo Shinichiro 久保紳一郎

KUBO Shinichiro 久保紳一郎

KUBO Shinitiro 久保紳一郎

[Book] 医学のあゆみ(ここまでわかったパーキンソン病研究医歯薬出版別冊)2008

[Book] 最新医学、別冊新しい診断と治療のABC2006