Morioka Norimitsu 森岡徳光

… Alternative Names

MORIOKA Norimitsu 森岡徳光

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Researcher Number	20346505
Other IDs
External Links
Affiliation (Current)	2025: 広島大学, 医系科学研究科(薬), 教授
Affiliation (based on the past Project Information) *help	2019 – 2023: 広島大学, 医系科学研究科(薬), 教授 2017 – 2018: 広島大学, 医歯薬保健学研究科(薬), 教授 2017: 広島大学, 大学院医歯薬保健学研究科(薬), 教授 2016: 広島大学, 医歯薬保健学研究院(薬), 教授 2014 – 2015: 広島大学, 医歯薬保健学研究院(薬), 准教授 … More 2013: 広島大学, 医歯薬保健学研究院, 准教授 2012: 広島大学, 医歯薬保健学研究院, 講師 2011: 広島大学, 大学院・医歯薬学総合研究科, 講師 2007 – 2008: Hiroshima University, Graduate School of Biomedical Sciences, Assistant Professor 2005 – 2006: 広島大学, 大学院医歯薬学総合研究科, 助手 2003 – 2005: 広島大学, 大学院・医歯薬学総合研究科, 助手 Less
Review Section/Research Field	Principal Investigator General pharmacology / Functional basic dentistry / Basic Section 47040:Pharmacology-related Except Principal Investigator Functional basic dentistry / General pharmacology / Basic Section 57030:Conservative dentistry-related / Basic Section 47040:Pharmacology-related / Basic Section 51030:Pathophysiologic neuroscience-related / Medium-sized Section 33:Organic chemistry and related fields / Basic Section 48030:Pharmacology-related / Psychiatric science / Pharmacology in pharmacy
Keywords	Principal Investigator アストロサイト / ミクログリア / 慢性疼痛 / 脊髄アストロサイト / 脊髄 / グルタミン酸トランスポーター / グリア細胞 / 核内受容体 / 鎮痛薬 / 神経障害性疼痛 … More / TNF / connexin43 / 疼痛 / 痛覚感受性異常 / ATP / ROR / 炎症性サイトカイン / マクロファージ / RORγ / 創薬 / SR9009 / 脊髄後角 / サイトカイン / REV-ERB / connexin36 / グルタミン酸 / プロテアソーム / ユビキチン / GSK-3β / cyclooxygenase-2 / interleukin-6 / TNF-α / proteasome / IFN-γ / 神経因性疼痛 / gap junction / PACAP / ノルアドレナリン / 時計遺伝子 / 概日リズム / 脊髄後根神経節 / グルタミン酸ホメオスタシス / P2X7 / グルタミン酸取り込み / アロディニア / 痛覚過敏 / P2X7受容体 … More Except Principal Investigator ミクログリア / アロディニア / 神経因性疼痛 / 神経障害性疼痛 / 認知機能障害 / うつ病 / CD38 / Cyclic ADP-ribose (cADPR) / 慢性疼痛 / NO / ATP / cGMP / 線条体 / グリシン / グリシンシグナル / 歯周病 / 神経炎症 / 認知症 / 肥満 / 精神神経疾患 / 細胞老化 / 細胞内in-situ合成 / 2光子反応 / 付加環化反応 / オキセタン / 生物活性物質 / 2光子励起 / 光[2+2]付加環化反応 / ドラッグデリバリー / ２光子励起 / 脳神経疾患 / 前頭前野 / リアルタイムfMRI / Depression / 薬理学 / マトリックスメタロプロテアーゼ / アストロサイト / 神経栄養因子 / グリア細胞 / 抗うつ薬 / リバースマイクロダイアリシス法 / 脳線条体 / substance P / 神経障害性疼痛モデルラット / サブスタンスＰ / volume transmitter / volume transmission / Pain / Volume transmitter / Striatum / Substance P / NT inhibitor / neucleoside transpoter (NT) / spinal pain sensation / glycine receptor α3 (GlyRα3) / descending inhibitory neuron / cyclic ADP-ribase (cADPR) / allodynia / neuropathic pain / 環状ADP-リポース / 抗炎症薬 / 鎮痛薬 / 抗アロディニア作用 / 痛覚伝達制御 / 環状ADPリボース / 炎症性疼痛 / 抗炎症作用 / 抗侵害作用 / NT阻害薬 / ヌクレオシドトランスポーター(NT) / cyclic ADP-ribose / Chemotaxis / Neucleotide transpoter / Ryanodine receptor channel / FK5O6-binding protein (FKBP) / Ca^<2+>-mobilization / human neutrophils / FK506-binding protein(FKBP) / FK506 / FK506-binding protein (FKBP) / 細胞内Ca^<2+>濃度([Ca^<2+>]i) / 好中球 / Cyclic ADP-ribose(cADPR) / 好中球遊走 / ヌクレオシドトランスポーター / リアノジン受容体チャネル / FK506-結合蛋白質(FKBP) / Ca^<2+>動員作用 / ヒト好中球 / Glvcine transporter / Microglia / Allodynia / Neuropathic pain / Platelet-Activating Factor / 神経損傷 / 脊髄 / PAF / 血書版活性化因子 / グリシントランスポーター / 血小板活性化因子 / 麻薬性鎮痛薬 / ホルマリン誘発性疼痛反応 / マイクロダイアリシス法 / allyl isothiocyanate(AITC) / dorsal root ganglion(DRG) / ラジオイムノアッセイ / allyl isothiocyanate (AITC) / 疼痛制御機構 / p38 MAPK / dorsal root ganglion (DRG) / TRPA1 / クロストーク / サブスタンスP / 後根神経節細胞 / 神経ペプチド / 知覚神経 / 神経因性疾痛 / KCC2 / RNA干渉 / シグナル伝達 / グリシントランスポーター阻害 / グリシントランスポーター阻害薬 / 鎮痛作用 / NMDA受容体 / グリシン受容体α3 / トランスポーター / 電動歯肉マッサージ / 非接触型 / 歯肉 / マッサージ法 / ナイロン製歯ブラシ / シリコン製マッサージ器具 / 細胞増殖 / 血流量 / 機械的刺激 Less

海馬ミクログリアサブセットに着目した神経障害性疼痛の病態解明と新規治療法への応用
- Principal Investigator
  
  中島一恵 (久岡一恵)
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Hiroshima University
Elucidating the mechanisms of interaction between obesity pathology and periodontal infection on cognitive function
- Principal Investigator
  
  大植香菜
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Hiroshima University
慢性疼痛における核内受容体RORsの機能解析と新規治療戦略への応用Principal Investigator
- Principal Investigator
  
  森岡徳光
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Hiroshima University
ミクログリアの細胞老化現象に着目した認知機能障害の発症・増悪機構の解明と応用
- Principal Investigator
  
  中村庸輝
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Hiroshima University
The role of anterior cingulate cortical microglia in pathophysiology of neuropathic pain and novel drug targets
- Principal Investigator
  
  Hisaoka-Nakashima Kazue
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Hiroshima University
In-situ synthesis of bioactive substances in a cell using near-infrared two-photon excitation
- Principal Investigator
  
  ABE MANABU
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 33:Organic chemistry and related fields
- Research Institution
  Hiroshima University
Role of nuclear receptor REV-ERB in chronic pain and their potential as therapeutic targets for analgesicsPrincipal Investigator
- Principal Investigator
  
  Morioka Norimitsu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Hiroshima University
The role of matrix metalloproteinase in the antidepressant-induced glial cell line-derived neurotrophic factor expression in astrocytes
- Principal Investigator
  
  Nakashima Kazue
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Hiroshima University
A new pain regulation systems activated by the crosstalk between brain striatum and neuropeptides
- Principal Investigator
  
  Nakata Yoshihiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Hiroshima University
Basic research on elucidation of neurocircuit pathology of depression and its remodeling mechanism
- Principal Investigator
  
  Yamawaki Shigeto
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Psychiatric science
- Research Institution
  Hiroshima University
Involvement of spinal gap junction in induction and maintenance of chronic painPrincipal Investigator
- Principal Investigator
  
  Morioka Norimitsu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Hiroshima University
The role of astroglial gap juncton in the regulation of chronic painPrincipal Investigator
- Principal Investigator
  
  MORIOKA Norimitsu
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Hiroshima University
A crosstalk between sensory neurons and surrounding cells
- Principal Investigator
  
  NAKATA Yoshihiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Hiroshima University
Role of glycine signal in the mechanism of neuropathic pain and development using siRNA for medicament.
- Principal Investigator
  
  KITAYAMA Tomoya
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Hiroshima University
The modulation of pain transduction mechanism through circadian clockPrincipal Investigator
- Principal Investigator
  
  MORIOKA Norimitsu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Hiroshima University
アロディニア発症の分子機構とその治療薬の開発に関する研究
- Principal Investigator
  
  土肥敏博
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Hiroshima University
Evidence of a role for cyclic ADP-ribose in pain transduction in spinal cord
- Principal Investigator
  
  MORITA Katsuya
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Hiroshima University
脊髄内神経-グリアネットワークによる疼痛制御機構-ATP受容体P2X7の役割-Principal Investigator
- Principal Investigator
  
  森岡徳光
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Hiroshima University
機械的刺激に対する細胞応答を利用した口腔組織の健康法に関する研究
- Principal Investigator
  
  DOHI Toshihiro
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Functional basic dentistry
- Research Institution
  Hiroshima University
脊髄グルタミン酸ホメオスタシス調節機構による疼痛制御-グルタミン酸トランスポーターの役割-Principal Investigator
- Principal Investigator
  
  森岡徳光
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Hiroshima University
The role of Platelet-Activating Factor (PAF) on the mechanisms of development of neuropathic pain. And its regulation
- Principal Investigator
  
  DOHI Toshihiro
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  HIROSHIMA UNIVERSITY
Evidence of a role for cyclic ADP-ribose in calcium signaling and migration in human neutrophils
- Principal Investigator
  
  MORITA Katsuya
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  HIROSHIMA UNIVERSITY

[Book] 月刊臨床神経科学(Clinical Neuroscience)2012
- Author(s)
  仲田義啓, 森岡徳光
- Total Pages
  4
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-21590280
[Journal Article] Mitochondrial dysfunction and type I interferon signaling induce anxiodepressive-like behaviors in mice with neuropathic pain2023
- Author(s)
  Yoshimoto Natsuki、Nakamura Yoki、Hisaoka-Nakashima Kazue、Morioka Norimitsu
- Journal Title
  
  Experimental Neurology
  
  Volume: 367 Pages: 114470-114470
- DOI
  10.1016/j.expneurol.2023.114470
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K06163
[Journal Article] Inhibition of nuclear receptor RORγ ameliorates mechanical hypersensitivity through the suppression of spinal microglial activation.2023
- Author(s)
  Morioka N, Tsuruta M, Masuda N, Yamano K, Nakano M, Kochi T, Nakamura Y, Hisaoka-Nakashima K
- Journal Title
  
  Neuroscience
  
  Volume: 526 Pages: 223-236
- DOI
  10.1016/j.neuroscience.2023.07.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06628
[Journal Article] High-mobility group box 1-mediated hippocampal microglial activation induces cognitive impairment in mice with neuropathic pain2022
- Author(s)
  Kazue Hisaoka-Nakashima, Kazuto Ohata, Natsuki Yoshimoto, Shintarou Tokuda, Nanako Yoshii, Yoki Nakamura, Dengli Wang, Keyue Liu, Hidenori Wake, Takayuki Yoshida, Yukio Ago, Kouichi Hashimoto, Masahiro Nishibori, Norimitsu Morioka
- Journal Title
  
  Exp Neurol .
  
  Volume: 355 Pages: 114146-114146
- DOI
  10.1016/j.expneurol.2022.114146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17930, KAKENHI-PROJECT-20K07291
[Journal Article] Anti-interleukin-6 receptor antibody improves allodynia and cognitive impairment in mice with neuropathic pain following partial sciatic nerve ligation2022
- Author(s)
  Hisaoka-Nakashima Kazue、Moriwaki Kodai、Yoshimoto Natsuki、Yoshii Toshiki、Nakamura Yoki、Ago Yukio、Morioka Norimitsu
- Journal Title
  
  International Immunopharmacology
  
  Volume: 112 Pages: 109219-109219
- DOI
  10.1016/j.intimp.2022.109219
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07291
[Journal Article] Perineural high-mobility group box 1 induces mechanical hypersensitivity through activation of spinal microglia: involvement of glutamate-NMDA receptor dependent mechanism in spinal dorsal horn.2021
- Author(s)
  Nakamura Y, Fukuta A, Miyashita K, Zhang FF, Wang D, Liu K, Wake H, Hisaoka-Nakashima K, Nishibori M, Morioka N
- Journal Title
  
  Biochem Pharmacol
  
  Volume: 186 Pages: 114496-114496
- DOI
  10.1016/j.bcp.2021.114496
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07291, KAKENHI-PROJECT-19H03408, KAKENHI-PROJECT-20K18476
[Journal Article] Stimulation of nuclear receptor REV-ERBs suppresses production of pronociceptive molecules in cultured spinal astrocytes and ameliorates mechanical hypersensitivity of inflammatory and neuropathic pain of mice2019
- Author(s)
  Morioka Norimitsu、Kodama Keitaro、Tomori Mizuki、Yoshikawa Kanade、Saeki Munenori、Nakamura Yoki、Zhang Fang Fang、Hisaoka-Nakashima Kazue、Nakata Yoshihiro
- Journal Title
  
  Brain, Behavior, and Immunity
  
  Volume: 印刷中 Pages: 116-130
- DOI
  10.1016/j.bbi.2019.01.014
- NAID
  120006847077
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08596
[Journal Article] High-mobility group box 1-mediated microglial activation induces anxiodepressive-like behaviors in mice with neuropathic pain2019
- Author(s)
  Hisaoka-Nakashima Kazue、Tomimura Yoshiaki、Yoshii Toshiki、Ohata Kazuto、Takada Naoki、Zhang Fang Fang、Nakamura Yoki、Liu Keyue、Wake Hidenori、Nishibori Masahiro、Nakata Yoshihiro、Morioka Norimitsu
- Journal Title
  
  Progress in Neuro-Psychopharmacology and Biological Psychiatry
  
  Volume: 92 Pages: 347-362
- DOI
  10.1016/j.pnpbp.2019.02.005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21225, KAKENHI-PROJECT-16K08270
[Journal Article] Pharmacological Activation Gi/o Protein Increases Glial Cell Line-Derived Neurotrophic Factor Production through Fibroblast Growth Factor Receptor and Extracellular Signal-Regulated Kinase Pathway in Primary Cultured Rat Cortical Astrocytes2017
- Author(s)
  Hisaoka-Nakashima K, Matsumoto C, Azuma H, Taki S, Takebayashi M, Nakata Y, Morioka N
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 40 Issue: 10 Pages: 1759-1766
- DOI
  10.1248/bpb.b17-00383
- NAID
  130006110587
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08270
[Journal Article] The expression of glial cell line-derived neurotrophic factor mRNA by antidepressants involves matrix metalloproteinase-9 activation in rat astroglial cells2016
- Author(s)
  Abe H, Hisaoka-Nakashima K, Kajitani N, Okada-Tsuchioka M, Yano R, Itagaki K, Shibasaki C, Morioka N, Nakata Y, Takebayashi M
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 479 Issue: 4 Pages: 907-912
- DOI
  10.1016/j.bbrc.2016.09.070
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09819, KAKENHI-PROJECT-16K08270, KAKENHI-PROJECT-16K18883, KAKENHI-PROJECT-16K19796
[Journal Article] Identification of lysophosphatidic acid receptor 1 in astroglial cells as a target for glial cell line-derived neurotrophic factor expression induced by antidepressants.2016
- Author(s)
  Kajitani, N., Miyano, K., Okada-Tsuchioka, M., Abe, H., Itagaki, K., Hisaoka-Nakashima, K., Morioka, N., Uezono, Y., Takebayashi, M.
- Journal Title
  
  J Biol Chem
  
  Volume: 291 Issue: 53 Pages: 27364-27370
- DOI
  10.1074/jbc.m116.753871
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08686, KAKENHI-PROJECT-15K09819, KAKENHI-PROJECT-16K08270, KAKENHI-PROJECT-16K18883, KAKENHI-PROJECT-16K19796
[Journal Article] Stimulation of spinal dorsal horn β2-adrenergic receptor ameliorates neuropathic mechanical hypersensitivity through a reduction of phosphorylation of microglial p38 MAP kinase and astrocytic c-jun N-terminal kinase.2016
- Author(s)
  Zhang F.F., Morioka N., Abe H., Fujii S., Miyauchi K., Nakamura Y., Hisaoka-Nakashima K., Nakata Y.
- Journal Title
  
  Neurochemistry International
  
  Volume: 101 Pages: 144-155
- DOI
  10.1016/j.neuint.2016.11.004
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460342
[Journal Article] Lycopene ameliorates neuropathic pain by upregulating spinal astrocytic connexin 43 expression.2016
- Author(s)
  Zhang F.F., Morioka N., Kitamura T., Fujii S., Miyauchi K., Nakamura Y., Hisaoka-Nakashima K., Nakata Y.
- Journal Title
  
  Life Sciences
  
  Volume: 155 Pages: 116-122
- DOI
  10.1016/j.lfs.2016.05.021
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460342
[Journal Article] Proinflammatory cytokines downregulate connexin 43-gap junction in rat spinal astrocytes via ubiquitin-proteasome system.2015
- Author(s)
  Zhang F.F., Morioka N., Kitamura T., Hisaoka-Nakashima K., Nakata Y.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 464 Issue: 4 Pages: 1202-1208
- DOI
  10.1016/j.bbrc.2015.07.105
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460342
[Journal Article] Downregulation of connexin36 in mouse spinal dorsal horn neurons leads to mechanical allodynia2015
- Author(s)
  Nakamura Y, Morioka N, Zhang FF, Hisaoka-Nakashima K, Nakata Y
- Journal Title
  
  Journal of Neuroscience Research
  
  Volume: 93 Issue: 4 Pages: 584-591
- DOI
  10.1002/jnr.23515
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460342
[Journal Article] Tumor necrosis factor-mediated downregulation of spinal astrocytic connexin43 leads to increased glutamatergic neurotransmission and neuropathic pain in mice.2015
- Author(s)
  Morioka N., Zhang F.F., Nakamura Y., Kitamura T., Hisaoka-Nakashima K., Nakata Y.
- Journal Title
  
  Ｂｒａｉｎ，　Ｂｅｈａｖｉｏｒ，　ａｎｄ　Ｉｍｍｕｎｉｔｙ
  
  Volume: 49 Pages: 293-310
- DOI
  10.1016/j.bbi.2015.06.015
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460342
[Journal Article] Amitriptyline up-regulates connexin43-gap junction in rat cultured cortical astrocytes via activation of the p38 and c-Fos/AP-1 signalling pathway.2014
- Author(s)
  Morioka N, Suekama K, Zhang FF, Kajitani N, Hisaoka-Nakashima K, Takebayashi M, Nakata Y.
- Journal Title
  
  British Journal of Pharmacology
  
  Volume: 171(11): Issue: 11 Pages: 2854-67
- DOI
  10.1111/bph.12614
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J06852, KAKENHI-PROJECT-23591686, KAKENHI-PROJECT-24790253
[Journal Article] Spinal astrocytes stimulated by tumor necrosis-αand/or interferon-γattenuate connexin 43-gap junction via c-jun terminal kinase activity2013
- Author(s)
  Zhang F.F, Morioka N, Nakashima-Hisaoka K, and Nakata Y
- Journal Title
  
  J. Neurosci. Res
  
  Volume: 91 Issue: 6 Pages: 745-756
- DOI
  10.1002/jnr.23213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790253
[Journal Article] Activation of Transient Receptor Potential Ankyrin 1 Evokes Nociception through Substance P Release from Primary Sensory Neurons2012
- Author(s)
  Yoki Nakamura, Yujiro Une, Kanako Miyano, Hiromi Abe, Kazue Hisaoka Norimitsu Morioka, and Yoshihiro Nakata
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 120 Pages: 1036-1047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590280
[Journal Article] Noradrenaline induces clock gene Per1 mRNA expression in C6 glioma cellsthrough β2-adrenergic receptors coupled with protein kinase A-cAMP response element binding protein and Src-tyrosine kinase-glycogen synthase kinase-3β2010
- Author(s)
  Norimitsu Morioka, Tatsuhiko Sugimoto, Masato Tokuhara, Toshihiro Dohi, Yoshihiro Nakata
- Journal Title
  
  J.Pharmacol.Sci.
  
  Volume: 113 Pages: 234-245
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590280
[Journal Article] Activation of the neurokinin-1 receptor in rat spinal astrocytes induces Ca^<2+> release from IP_3-sensitive Ca^<2+> stores and extracellular Ca^<2+> influx through TRPC32010
- Author(s)
  Kanako Miyano Norimitsu Morioka, Tatsuhiko Sugimoto, Seiji Shiraishi, Yasuhito Uezono, Yoshihiro Nakata
- Journal Title
  
  Neurochemistry International
  
  Volume: 57 Pages: 923-4934
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590280
[Journal Article] Paclitaxel and vinorelbine, evoked the release of substance P from cultured rat dorsal root ganglion cells through different PKC isoform-sensitive ion channels2009
- Author(s)
  Kanako Miyano, He-Bin Tang, Norimitsu Morioka, Yoshihiro Nakata
- Journal Title
  
  Neuropharmacology 57
  
  Pages: 25-32
- NAID
  120001700468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590280
[Journal Article] P2X(7) receptor stimulation in primary cultures of rat spinal microglia induces downregulation of the activity for glutamates transporter2008
- Author(s)
  Morioka N., Abdin M.J., Kitayama T., Morita K., Nakata Y. and Dohi T.
- Journal Title
  
  Glia 56
  
  Pages: 528-538
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19791365
[Journal Article] Glycinergic mediation of tactile allodynia induced by platelet-activating factor (PAF) through glutamate-NO-cyclic GMP signaling in spinal cord in mice2008
- Author(s)
  Morita K., Kitayama T., Morioka N. and Dohi T.
- Journal Title
  
  Pain 138
  
  Pages: 525-536
- NAID
  120001092434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19791365
[Journal Article] Cyclic ADP-ribose mediates formyl methionyl leucyl phenylalanine (fMLP)-induced intracellular Ca^<2+> rise and migration of human neutrophils.2008
- Author(s)
  Katsuya Morita, Minoru Saida, Norimitsu Morioka, Tomoya Kitayama, Yasumasa Akagawa, Toshihiro Dohi
- Journal Title
  
  Journal of Pharmacological Sciences 106-3
  
  Pages: 492-504
- NAID
  10024319493
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18592036
[Journal Article] The regulation of glycine transporter GLYT1 is mainly mediated by protein kinase Calpha in C6 glioma cells.2008
- Author(s)
  Norimitsu Morioka, et al.
- Journal Title
  
  Neurochem. Int 53
  
  Pages: 248-254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390491
[Journal Article] The regulation of glycine transporter GlyT1 is mainly mediated by protein kinase Calpha in C6 glioma cells2008
- Author(s)
  Morioka Norimitsu
- Journal Title
  
  Neurochem. Int. 53
  
  Pages: 248-254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19791365
[Journal Article] The regulation of glycine transporter GlyT1 is mainly mediated by protein kinase Calpha in C6 glioma cells2008
- Author(s)
  Morioka N., Abdin JM., Morita K., Kitayama T., Nakata Y. and Dohi T.
- Journal Title
  
  Neurochem. Int., 53
  
  Pages: 248-254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19791365
[Journal Article] Spinal anti-allodynia action of glycine transporter inhibitors in neuropathic pain models in mice2008
- Author(s)
  Morita K., Motoyama N., Kitayama T., Morioka N., Kifune K. and Dohi T.
- Journal Title
  
  J. Pharmacol. Exp.Ther., 326
  
  Pages: 633-645
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19791365
[Journal Article] Mechanisms of pain sensitization and the treatments2006
- Author(s)
  T.Dohi, K.Morita, N.Morioka, J.Abdin, T.Kitayama, N.Motoyama, F.Zohn
- Journal Title
  
  Hiroshima Conference on Education and Science in Dentistry, 2006
  
  Pages: 87-95
- NAID
  120006665073
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390562
[Journal Article] Mechanisms of pain sensitization and the treatments2006
- Author(s)
  T.Dohi, K.Morita, N.Morioka, J.Abdln, T.Kitayama, N.Motoyama, R.Zohn
- Journal Title
  
  Hiroshima Conference on Education and Science in Dentistry, 2006
  
  Pages: 87-95
- NAID
  120006665073
- Data Source
  KAKENHI-PROJECT-15390562
[Journal Article] 脊髄の痛覚伝導における血小板活性化因子(PAF)の役割2006
- Author(s)
  土肥敏博, 森田克也, 森岡徳光, Md.Joynal Abdin, 北山友也, 北山滋雄, 仲田義啓
- Journal Title
  
  日本薬理学雑誌 127
  
  Pages: 18-24
- NAID
  10017495004
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390562
[Journal Article] 脊髄の痛覚伝導における血小板活性化因子(PAF)の役割2006
- Author(s)
  土肥敏博, 森田克也, 森岡徳光, Md.JoynalAbdin, 北山友也, 北山滋雄, 仲田義啓
- Journal Title
  
  日本薬理学雑誌 127
  
  Pages: 18-24
- NAID
  10017495004
- Data Source
  KAKENHI-PROJECT-15390562
[Journal Article] Nonsteroidal anti-inflammatory drugs potentiate 1-methyl-4-phenyl-pyridinium (MPP^+)-induced cell death by promoting the intracellular accumulation of MPP^+ in PC12 cells.2004
- Author(s)
  N.Morioka
- Journal Title
  
  The Journal of Pharmacology and Experimental Therapeutics 310
  
  Pages: 800-807
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390562
[Journal Article] Nonsteroidal anti-inflammatory drugs potentiate 1-methyl-4-phenyl-pyridinium (MPP^<+>)-induced cell death by promoting the intracellular accumulation of MPP^+ in PC12 cells.2004
- Author(s)
  N.Morioka, K.Kumagai, K.Morita, S.Kitayama, T.Dohi
- Journal Title
  
  The Journal of Pharmacology and Experimental Therapeutics 310
  
  Pages: 800-807
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390562
[Journal Article] Development of tactile allodynia and thermal hyperalgesia by intrathecally administered platelet-activating factor in mice.2004
- Author(s)
  K.Morita, N.Morioka, J.Abdin, S.Kitayama, Y.Nakata, T.Dohi
- Journal Title
  
  Pain 111
  
  Pages: 351-359
- NAID
  120000881206
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390562
[Journal Article] Development of tactile allodynia and thermal hyperalgesia by intrathecally administered platelet-activating factor in mice2004
- Author(s)
  K.Morita, N.Morioka, J.Abdin, S.Kitayama, Y.Nakata, T.Dohi
- Journal Title
  
  Pain 111
  
  Pages: 351-359
- NAID
  120000881206
- Data Source
  KAKENHI-PROJECT-15390562
[Journal Article] Nonsteroidal ant-inflammatory drugs potentiate 1-methyl-4-phenyl-pyridinium (MPP^+)-induced cell death by promoting the intracellularaccumulation of MPP^+ in PC12 cells.2004
- Author(s)
  N.Morioka, K.Kumagai, K.Morita, S.Kitayama, T.Dohi
- Journal Title
  
  The Journal of Pharmacology and Experimental Therapeutics 310
  
  Pages: 800-807
- Data Source
  KAKENHI-PROJECT-15390562
[Presentation] ミクログリアの細胞老化に着目した老化マウスのうつ・不安様症状の解析2024
- Author(s)
  横畠未来、中村庸輝、池田圭佑、中島一恵、吾郷由希夫、佐藤綾美、石神昭人、森岡徳光
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K07371
[Presentation] 核内受容体 RORγ 阻害薬はミクログリア活性を抑制することで疼痛緩和効果を示す2024
- Author(s)
  升田菜緒、鶴田真帆、中村庸輝、中島一恵、森岡徳光
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K06628
[Presentation] 神経障害性疼痛モデルマウスにおける不安・うつ様行動に対するHMGB1中和抗体経鼻投与の効果の検討2024
- Author(s)
  田上浩司、中島一恵、中村庸輝、西堀正洋、森岡徳光
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K06163
[Presentation] ミクログリアへ及ぼす加齢の影響2023
- Author(s)
  中村庸輝、中島一恵、森岡徳光
- Organizer
  第46回日本基礎老化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K07371
[Presentation] ミトコンドリア機能障害は mitochondrial DNA - cyclic GMP-AMP synthase を介してミクログリアの炎症応答を変化させる2023
- Author(s)
  中野雅凪矢、中村庸輝、岩本桃香、中島一恵、森岡徳光
- Organizer
  第143回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-22K07371
[Presentation] パーキンソン病関連性疼痛に対する high mobility group box-1 中和抗体の鎮痛効果2023
- Author(s)
  中村庸輝、佐藤史爽、山野樹一、麻思萌、河内貴弘、中島一恵、王登莉、劉克約、和氣秀徳、西堀正洋、森岡徳光
- Organizer
  第53回日本神経精神薬理学会年会
- Data Source
  KAKENHI-PROJECT-22K07371
[Presentation] ミクログリアに対するロテノン処置は細胞質ミトコンドリア DNA 漏出を介して I 型インターフェロン産生を増強する2023
- Author(s)
  中村庸輝、中野雅凪矢、岩本桃香、中島一恵、森岡徳光
- Organizer
  フォーラム2023 - 衛生薬学・環境トキシコロジー -
- Data Source
  KAKENHI-PROJECT-22K07371
[Presentation] Blockade of high mobility group box-1 function ameriolates mechanical hypersensitivity in a mouse model of Parkinson's disease2023
- Author(s)
  Nakamura Y, Sato F, Yamano K, Ma S, Kochi T, Hisaoka-Nakashima K, Wang D, Liu K, Wake H, Nishibori M, Morioka N
- Organizer
  IAGG Asia/Oceania Regional Congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07371
[Presentation] Periodontal infection in diet-induced obesity causes cognitive impairment associated with microglial activation.2023
- Author(s)
  Kana Oue, Yusuke Morioka, Eiji Imado, Testuya Tamura, Yosuke Yamawaki, Kazuhisa Ouhara, Mitsuhiro Yoshida, Takashi Kanematsu, Yukio Ago
- Organizer
  IAGG Asia/Oceania Regional Congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K09183
[Presentation] 加齢に伴うミクログリア機能変容の解明を目指した新規研究手法の確立2023
- Author(s)
  中村庸輝、中島一恵、森岡徳光
- Organizer
  第97回日本薬理学会年会・第44回日本臨床薬理学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-22K07371
[Presentation] 神経障害性疼痛マウスの認知機能低下における脳ミクログリアの役割に関する検討2023
- Author(s)
  吉井　菜々子、中島　一恵、中村　庸輝、森岡　徳光
- Organizer
  第62回日本薬学会・日本薬剤師会・日本病院薬剤師会
- Data Source
  KAKENHI-PROJECT-23K06163
[Presentation] 神経障害性疼痛による認知機能障害発症メカニズムの解明 ‐clodronate liposomeを用いた検討‐2023
- Author(s)
  徳田　慎太朗、中島　一恵、中村　庸輝、森岡　徳光
- Organizer
  第62回日本薬学会・日本薬剤師会・日本病院薬剤師会
- Data Source
  KAKENHI-PROJECT-23K06163
[Presentation] Mitochondrial DNA- cyclic GMP-AMP synthase 経路がミクログリアの炎症応答に及ぼす影響2023
- Author(s)
  中野雅凪矢、中村庸輝、岩本桃香、森岡徳光、中島一恵
- Organizer
  第97回日本薬理学会年会・第44回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-22K07371
[Presentation] The emerging role of HMGB1 in the brain during chronic pain.2023
- Author(s)
  Nakamura Y, Nakashima K, Morioka N
- Organizer
  19th World Congress of Basic & Clinical Pharmacology 2023 (WCP2023)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07371
[Presentation] ミクログリアにおけるミトコンドリア機能障害は mitochondrial DNA-cyclic GMP-AMP synthase を介し interferonβ 産生を増強する2023
- Author(s)
  中野雅凪矢、中村庸輝、岩本桃香、中島一恵、森岡徳光
- Organizer
  次世代を担う若手のための創薬・医療薬理シンポジウム 2023
- Data Source
  KAKENHI-PROJECT-22K07371
[Presentation] 細胞質へ漏出したミトコンドリア DNA のミクログリアの炎症反応へ及ぼす影響2022
- Author(s)
  中村庸輝、中島一恵、森岡徳光
- Organizer
  第96回日本薬理学会年会・第43回日本臨床薬理学会学術総会 (JPW2022)
- Data Source
  KAKENHI-PROJECT-22K07371
[Presentation] 神経障害性疼痛マウスにおける認知機能障害に対するHMGB1中和抗体の効果に関する検討2022
- Author(s)
  吉本夏輝、中島一恵、大畑一努、中村庸輝、王登莉、劉克約、和氣秀徳、吾郷由希夫、西堀正洋、森岡徳光
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07291
[Presentation] Cytosolic mitochondrial DNA enhances the IRF3 response in microglia with mitochondrial dysfunction2022
- Author(s)
  中村庸輝、中野雅凪矢、池田圭佑、岩本桃香、中島一恵、森岡徳光
- Organizer
  第45回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-22K07371
[Presentation] 老化様ミクログリアにおける炎症応答変化の解析2022
- Author(s)
  池田圭佑、中村庸輝、中野雅凪矢、中島一恵、森岡徳光
- Organizer
  第 1 回広島大学脳神経科学セミナー
- Data Source
  KAKENHI-PROJECT-22K07371
[Presentation] 難治性疼痛に対する創薬標的としての HMGB1 の可能性2022
- Author(s)
  中村庸輝、中島一恵、森岡徳光
- Organizer
  生体機能と創薬シンポジウム 2022
- Invited
- Data Source
  KAKENHI-PROJECT-20K07291
[Presentation] 老化様ミクログリア作製手法の確立と炎症応答変化の解析2022
- Author(s)
  中村庸輝, 池田圭佑, 中野雅凪矢, 中島一恵, 森岡徳光
- Organizer
  第38回創薬・薬理フォーラム岡山
- Data Source
  KAKENHI-PROJECT-22K07371
[Presentation] 慢性疼痛モデル：抗体製剤の経鼻投与による疼痛と付随する情動・認知機能異常に対する改善効果2022
- Author(s)
  森岡徳光、中村庸輝、中島一恵、西堀正洋
- Organizer
  第96回日本薬理学会年会・第43回日本臨床薬理学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07291
[Presentation] 老化様ミクログリアの作製方法の確立と炎症応答変化の解析2022
- Author(s)
  池田圭佑、中村庸輝、中野雅凪矢、中島一恵、森岡徳光
- Organizer
  第142回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-22K07371
[Presentation] ラット大脳皮質由来初代培養ミクログリアにおけるglucocorticoid誘導性 high-mobility group box-1放出メカニズムの検討2022
- Author(s)
  竹内佑香、中島一恵、中村庸輝、王登莉、劉克約、西堀正洋、森岡徳光
- Organizer
  第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-20K07291
[Presentation] 海馬のミトコンドリア機能障害は神経障害性疼痛マウスに不安・うつ行動を誘発する2022
- Author(s)
  吉本夏輝、中島一恵、中村庸輝、森岡徳光
- Organizer
  第96回日本薬理学会年会・第43回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07291
[Presentation] ミクログリアのミトコンドリア機能障害と炎症応答変化2022
- Author(s)
  中村庸輝、中野雅凪矢、池田圭佑、中島一恵、森岡徳光
- Organizer
  第 1 回広島大学脳神経科学セミナー
- Data Source
  KAKENHI-PROJECT-22K07371
[Presentation] 神経障害性疼痛により生じる認知機能低下に対するHMGB1の関与2021
- Author(s)
  中島一恵, 大畑一努, 森脇航大, 吉本夏輝, 中村庸輝, 王登莉, 劉克約, 和氣秀徳, 西堀正洋, 森岡徳光
- Organizer
  第43回日本生物学的精神医学会第51回日本神経精神薬理学会合同年会
- Data Source
  KAKENHI-PROJECT-20K07291
[Presentation] 慢性疼痛によるストレスがもたらす情動・認知機能異常へのhigh mobility box-1とミクログリアの関与2021
- Author(s)
  森岡徳光, 中島一恵, 中村庸輝
- Organizer
  第43回日本生物学的精神医学会第51回日本神経精神薬理学会合同年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07291
[Presentation] 神経障害性疼痛モデルマウスの脳におけるミトコンドリア由来DAMPsの発現変化に関する検討2021
- Author(s)
  吉本夏輝、中島一恵、中村庸輝、森岡徳光
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K07291
[Presentation] 神経障害性疼痛モデルマウスにおける海馬での神経可塑性変化に関する検討2021
- Author(s)
  吉本夏輝、中島一恵、中村庸輝、吾郷由紀夫、森岡徳光
- Organizer
  第60回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-20K07291
[Presentation] 神経障害性疼痛モデルマウスにおける脳内ミトコンドリア由来DAMPs発現変化とミトコンドリア機能障害に関する検討2021
- Author(s)
  吉本夏輝、中島一恵、中村庸輝、森岡徳光
- Organizer
  第139回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-20K07291
[Presentation] 神経障害性疼痛マウスの認知機能低下に対するHMGB1の役割に関する検討2020
- Author(s)
  大畑一努、中島一恵、森脇航大、吉本夏輝、中村庸輝、王登莉、劉克約、和氣秀徳、西堀正洋、森岡徳光
- Organizer
  第59回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-20K07291
[Presentation] ミクログリアにおける核内受容体 REV-ERBs の炎症制御機構の解明2019
- Author(s)
  児玉景太郎, 鶴田真帆, 武村昌俊, 岩本桃香, 中村庸輝, 中島一恵, 森岡徳光
- Organizer
  第136回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-17K08596
[Presentation] Effects of nuclear receptor reverb on proinflammatory responses in cultured microglia.2019
- Author(s)
  Kodama K, Yoshikawa K, Takemura M, Nakamura Y, Nakashima K, Morioka N
- Organizer
  Society for Neuroscience Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08596
[Presentation] ラット大脳皮質初代培養アストロサイトにおいてミルタザピンはGDNF 産生を増加する2018
- Author(s)
  高城　冴花、中島　一恵、渡辺　慎太郎、中村　庸輝、仲田　義啓、森岡　徳光
- Organizer
  第57回日本薬学会・日本病院薬剤師会・中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-16K08270
[Presentation] 脊髄アストロサイトにおける核内受容体REV-ERBsを介した炎症性疼痛緩和効果の検討2018
- Author(s)
  吉川　奏，児玉景太郎，中村庸輝，中島一恵，仲田義啓, 森岡徳光
- Organizer
  第57回日本薬学会・日本薬剤師会・日本病院薬剤師会・中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-17K08596
[Presentation] The analysis of anxiety- and depression-related behaviors in neuropathic pain of mice - possible involvement of brain inflammation2018
- Author(s)
  Kazue Hisaoka-Nakashima, Yoshiaki Tomimura, Toshiki Yoshii, Fang Fang Zhang, Yoki Nakamura, Keyue Liu, Masahiro Nishibori, Yoshihiro Nakata, Norimitsu Morioka
- Organizer
  The 18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08270
[Presentation] 神経障害性疼痛モデルマウスにおけるうつ様行動と脳ミクログリア機能解析2017
- Author(s)
  中島一恵、富村昌暉、吉井稔紀、張　芳芳、仲田義啓、森岡徳光
- Organizer
  第39回日本生物学的精神医学会・第47回日本神経精神薬理学会合同年会
- Data Source
  KAKENHI-PROJECT-16K08270
[Presentation] 脳線条体におけるdopamine-substance P系を介した疼痛抑制メカニズムの解明2017
- Author(s)
  岸田祐輝、中村庸輝、中島一恵、仲田義啓、森岡徳光
- Organizer
  第 56 回日本薬学会・日本薬剤師会・日本病院薬剤師会
- Data Source
  KAKENHI-PROJECT-15K08233
[Presentation] Antidepressant amitriptyline activates matrix metalloproteinase in astroglial cells: involvement in glial cell line-derived neurotrophic factor expression.2016
- Author(s)
  H. ABE, K. HISAOKA-NAKASHIMA, N. KAJITANI, M. OKADA-TSUCHIOKA, K. ITAGAKI, C. SHIBASAKI, M. MORIOKA, Y. NAKATA, M. TAKEBAYASHI
- Organizer
  30th CINP WORLD CONGRESS OF NEUROPSYCHOPHARMACOLOGY
- Place of Presentation
  Seoul
- Year and Date
  2016-07-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08270
[Presentation] Involvement of the striatal substance P nervous system in regulation of nociceptive transmission.2016
- Author(s)
  福重　亮, 中村庸輝, 森岡徳光, 仲田義啓
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  横浜市
- Year and Date
  2016-03-10
- Data Source
  KAKENHI-PROJECT-15K08233
[Presentation] 脳線条体へのsubstance P持続投与により誘発される疼痛制御機構の解明2016
- Author(s)
  福重　亮, 中村庸輝, 森岡徳光, 仲田義啓
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜市
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-15K08233
[Presentation] A role of spinal astrocytic connexin43 in maintenance of neuropathic pain.2016
- Author(s)
  藤井志織, 森岡徳光, 張　芳芳, 中島一恵, 仲田義啓
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-03-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460342
[Presentation] 脊髄アストロサイトにおけるconnexin43の発現低下はIL-6及びCOX-2の発現増加を介して痛みを誘発する2016
- Author(s)
  藤井志織, 張　芳芳, 中島一恵, 仲田義啓, 森岡徳光
- Organizer
  第130回日本薬理学会近畿部会
- Place of Presentation
  京都大学百周年時計台記念館
- Data Source
  KAKENHI-PROJECT-26460342
[Presentation] 神経障害性疼痛発症時における脊髄アストロサイトConnexin43の新たな役割2016
- Author(s)
  藤井志織, 張　芳芳, 中島一恵, 仲田義啓, 森岡徳光
- Organizer
  第129回日本薬理学会近畿部会
- Place of Presentation
  広島県医師会館
- Data Source
  KAKENHI-PROJECT-26460342
[Presentation] 慢性疼痛時での脳線条体substance Pを介した疼痛制御機構2016
- Author(s)
  福重　亮, 中村庸輝, 森岡徳光, 仲田義啓
- Organizer
  第129回日本薬理学会近畿部会
- Place of Presentation
  広島市
- Year and Date
  2016-06-24
- Data Source
  KAKENHI-PROJECT-15K08233
[Presentation] ラット初代培養アストロサイトにおいてリゾフォスファチジン酸がトロンボスポンジン１発現に与える効果の検討2016
- Author(s)
  横江俊樹、中島一恵、東穂奈美、高城冴花、仲田義啓、森岡徳光
- Organizer
  第55回日本薬学会・日本薬剤師会・日本病院薬剤師会　中国四国支部学術大会
- Place of Presentation
  岡山
- Year and Date
  2016-11-05
- Data Source
  KAKENHI-PROJECT-16K08270
[Presentation] 線条体サブスタンスＰ神経系の疼痛抑制作用とドーパミン神経系との関係2015
- Author(s)
  渡部亨平、福重亮、岸田祐輝、中村庸輝　森岡徳光、仲田義啓
- Organizer
  第 54 回　日本薬学会・日本薬剤師会・日本病院薬剤師会
- Place of Presentation
  高知市
- Year and Date
  2015-10-31
- Data Source
  KAKENHI-PROJECT-15K08233
[Presentation] 神経障害性疼痛モデルラットにおける脳線条体substance P神経系を介した疼痛制御機構2015
- Author(s)
  福重　亮, 中村庸輝, 森岡徳光, 仲田義啓
- Organizer
  次世代を担う創薬・医療薬理シンポジウム2015
- Place of Presentation
  東京都
- Year and Date
  2015-08-30
- Data Source
  KAKENHI-PROJECT-15K08233
[Presentation] 線条体サブスタンスＰ神経系による疼痛抑制作用のメカニズム2015
- Author(s)
  渡部亨平、福重亮、岸田祐輝、中村庸輝　森岡徳光、仲田義啓
- Organizer
  第128回　日本薬理学会近畿部会
- Place of Presentation
  吹田市
- Year and Date
  2015-11-20
- Data Source
  KAKENHI-PROJECT-15K08233
[Presentation] The role of spinal astrocytic Cx43 in the maintenance of neuropathic pain2015
- Author(s)
  Zhang F., Morioka N., Nakamura Y., Fujii S., Hisaoka-Nakashima K., Nakata Y.
- Organizer
  45th Annual Meeting of Society for Neuroscience
- Place of Presentation
  Chicago, USA
- Year and Date
  2015-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460342
[Presentation] 脊髄アストロサイトConnexin43発現低下による神経障害性疼痛発症メカニズムの解析2015
- Author(s)
  藤井志織, 森岡徳光, 張　芳芳, 中島一恵, 仲田義啓
- Organizer
  次世代を担う創薬・医療薬理シンポジウム2015
- Place of Presentation
  東京大学薬学部
- Year and Date
  2015-08-29
- Data Source
  KAKENHI-PROJECT-26460342
[Presentation] 難治性疼痛発症メカニズムに関与する新規制御因子の探索とその治療戦略2015
- Author(s)
  森岡徳光
- Organizer
  生体機能と創薬シンポジウム2015
- Place of Presentation
  日本大学薬学部
- Year and Date
  2015-08-28
- Invited
- Data Source
  KAKENHI-PROJECT-26460342
[Presentation] 脊髄アストロサイトgap junction-Cx43発現低下に対するproteasome系の役割2014
- Author(s)
  張　芳芳、森岡徳光、北村智哉、藤井志織、中島一恵、仲田義啓
- Organizer
  第125回日本薬理学会近畿部会
- Place of Presentation
  岡山コンベンションセンター
- Year and Date
  2014-06-20
- Data Source
  KAKENHI-PROJECT-26460342
[Presentation] 脊髄アストロサイトConnexin43の神経障害性疼痛発症への関与2014
- Author(s)
  北村智哉、森岡徳光、張　芳芳、藤井志織、中島一恵、仲田義啓
- Organizer
  第53回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  広島国際会議場
- Year and Date
  2014-11-08
- Data Source
  KAKENHI-PROJECT-26460342
[Presentation] 脊髄アストロサイトConnexin43の神経障害性疼痛における機能解明2014
- Author(s)
  北村智哉、森岡徳光、張　芳芳、中島一恵、仲田義啓
- Organizer
  次世代を担う創薬・医療薬理シンポジウム2014
- Place of Presentation
  近畿大学東大阪キャンパス
- Year and Date
  2014-08-30
- Data Source
  KAKENHI-PROJECT-26460342
[Presentation] 神経障害性疼痛に対する脊髄後角におけるアストロサイトCx43の関与2014
- Author(s)
  張　芳芳、森岡徳光、北村智哉、藤井志織、中島一恵、仲田義啓
- Organizer
  第126回日本薬理学会近畿部会
- Place of Presentation
  和歌山県JAビル
- Year and Date
  2014-10-24
- Data Source
  KAKENHI-PROJECT-26460342
[Presentation] 脊髄アストロサイトにおけるTNF-α及びIFN-γによるCx43発現低下に対するプロテアソームの関与2014
- Author(s)
  張芳芳, 森岡徳光, 北村智哉, 中島一恵, 仲田義啓
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  宮城
- Year and Date
  2014-03-21
- Data Source
  KAKENHI-PROJECT-24790253
[Presentation] 脊髄アストロサイトにおけるTNF-α及びIFN-γによるCx43発現低下に対するプロテアソームの関与2014
- Author(s)
  張　芳芳、森岡徳光、北村智哉、中島一恵、仲田義啓
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  宮城県仙台市
- Data Source
  KAKENHI-PROJECT-24790253
[Presentation] TNF-α及びIFN-γによる脊髄アストロサイトにおけるCx-43-gap junctionの発現制御機構2013
- Author(s)
  張芳芳, 森岡徳光, 北村智哉, 中村庸輝, 中島一恵, 仲田義啓
- Organizer
  第123回日本薬理学会近畿部会
- Place of Presentation
  愛知
- Year and Date
  2013-07-12
- Data Source
  KAKENHI-PROJECT-24790253
[Presentation] TNF-α及びIFN-γによる脊髄アストロサイトにおけるCx43-gap junctionの発現制御機構2013
- Author(s)
  張　芳芳、森岡徳光、北村智哉、中村庸輝、中島一恵、仲田義啓
- Organizer
  第123回日本薬理学会近畿部会
- Place of Presentation
  愛知県名古屋市
- Data Source
  KAKENHI-PROJECT-24790253
[Presentation] 脊髄アストロサイトにおけるサイトカイン処置によるCx43-gap junction機能低下に対するJNKの役割2013
- Author(s)
  張　芳芳、森岡徳光、中村庸輝、中島一恵、仲田義啓
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-24790253
[Presentation] Down-regulation of Cx43-gap junction expression in rat cultured spinal astrocytes by TNF-αand/or IFN-γ2013
- Author(s)
  Zhang FF, Morioka N, Kitamura T, Hisaoka-Nakashima K, Nakata Y
- Organizer
  The 10^<th> Biennial Conference of the Chinese Neuroscience Society
- Place of Presentation
  Beijing, China
- Year and Date
  2013-09-20
- Data Source
  KAKENHI-PROJECT-24790253
[Presentation] Down-regulation of Cx43-gap junction expression in rat cultured spinal astrocytes by TNF-α and/or IFN-γ2013
- Author(s)
  Zhang FF, Morioka N, Kitamura T, Hisaoka-Nakashima K, Nakata Y
- Organizer
  The 10th Biennial Conference of the Chinese Neuroscience Society
- Place of Presentation
  Benjing, China
- Data Source
  KAKENHI-PROJECT-24790253
[Presentation] 炎症性サイトカインによる脊髄アストロサイトのGap junction-connexin43発現制御機構の検討2011
- Author(s)
  張芳芳, 森岡徳光, 中村庸輝, 徳原昌人, 中島(久岡)一恵, 仲田義啓
- Organizer
  第50回日本薬学会中国四国支部学術大会
- Place of Presentation
  香川
- Year and Date
  2011-11-13
- Data Source
  KAKENHI-PROJECT-24790253
[Presentation] ラット脊髄後根神経節初代培養細胞におけるTRPA1受容体活性化によるサブスタンスP遊離へのp38MAP kinaseの関与2011
- Author(s)
  中村庸輝, 宇根裕次郎, 安部裕美, 久岡一恵, 森岡徳光, 仲田義啓
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-21590280
[Presentation] ラット脊髄後根神経節初代培養細胞におけるTRPA1受容体活性化によるサブスクンスP遊離へのp38MAP kinaseの関与2011
- Author(s)
  中村庸輝, 宇根裕次郎, 安部裕美, 久岡一恵, 森岡徳光, 仲田義啓
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-21590280
[Presentation] TRPA1刺激による知覚神経からのサブスタンスP遊離機構の解明2010
- Author(s)
  宇根裕次郎, 中村庸輝, , 安部裕美, 久岡一恵, 森岡徳光, 仲田義啓
- Organizer
  第118回日本薬理学会近畿部会
- Place of Presentation
  大阪市
- Year and Date
  2010-11-19
- Data Source
  KAKENHI-PROJECT-21590280
[Presentation] C6グリア細胞株におけるノルアドレナリンによる時計遺伝子Per1発現制御機構の解明2009
- Author(s)
  森岡徳光
- Organizer
  第82回薬理学会年会
- Place of Presentation
  パシフイコ横浜
- Year and Date
  2009-03-16
- Data Source
  KAKENHI-PROJECT-19791366
[Presentation] C6グリア細胞株におけるノルアドレナリンによる時計遺伝子Per1発現制御機構の解明2009
- Author(s)
  森岡徳光
- Organizer
  第82回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-03-16
- Data Source
  KAKENHI-PROJECT-19791366
[Presentation] 脊髄後根神経節初代培養細胞におけるパクリタキセルおよびビノレルビンのサブスタンスP遊離に対する効果2009
- Author(s)
  宮野加奈子, 中村庸輝, 唐和斌, 森岡徳光, 井上敦子, 仲田義啓
- Organizer
  第82回日本薬理学会年会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-21590280
[Presentation] 脊髄ミクログリアにおけるATP受容体を介したグルタミン酸トランスポーター制御機構2008
- Author(s)
  森岡徳光
- Organizer
  第3回トランスポーター研究会年会
- Place of Presentation
  京都
- Year and Date
  2008-06-08
- Data Source
  KAKENHI-PROJECT-19791365
[Presentation] 脊髄ミクログリアにおけるATP受容体を介したグルタミン酸トランスポーター機能調節2007
- Author(s)
  森岡徳光
- Organizer
  第35回薬物活性シンポジウム
- Place of Presentation
  広島
- Year and Date
  2007-11-30
- Data Source
  KAKENHI-PROJECT-19791365
[Presentation] Intrathecal injection of cyclic ADP-ribose induces hyperalgesia and allodynia2006
- Author(s)
  Naoyo Motoyama, Katsuya Morita, Koki Kifune, Norimitsu Morioka, Tomoya Kitayama, Toshihiro Dohi
- Organizer
  The 48th Annual Meeting of Japanese Association for Oral Biology
- Place of Presentation
  Tsurumi
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18592036

1. Nakashima Kazue (20393431)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
2. MORITA Katsuya (10116684)

# of Collaborated Projects: 6 results

# of Collaborated Products: 14 results
3. NAKATA Yoshihiro (40133152)

# of Collaborated Projects: 6 results

# of Collaborated Products: 41 results
4. DOHI Toshihiro (00034182)

# of Collaborated Projects: 5 results

# of Collaborated Products: 10 results
5. KITAYAMA Tomoya (60363082)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
6. KITAYAMA Shigeo (80177873)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
7. 中村庸輝 (60711786)

# of Collaborated Projects: 4 results

# of Collaborated Products: 36 results
8. MOTOYAMA Naoyo (70509661)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. Yamawaki Shigeto (40230601)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Okamoto Yasumasa (70314763)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Okada Go (10457286)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Hashimoto Koichi (00303272)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Yamawaki Yosuke (90584061)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. ABE MANABU (30273577)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 竹本俊伸 (00236506)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 淵上学 (40403571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 吉野敦雄 (90633727)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 大植香菜 (60760329)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. 吾郷由希夫 (50403027)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. 應原一久 (80550425)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. HISAOKA Kazue

# of Collaborated Projects: 0 results

# of Collaborated Products: 58 results
22. OKADA Mami

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 竹林実

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 上園保仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 王登莉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Morioka Norimitsu 森岡 徳光

MORIOKA Norimitsu 森岡 徳光

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慢性疼痛における核内受容体RORsの機能解析と新規治療戦略への応用Principal Investigator

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Role of nuclear receptor REV-ERB in chronic pain and their potential as therapeutic targets for analgesicsPrincipal Investigator

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Involvement of spinal gap junction in induction and maintenance of chronic painPrincipal Investigator

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The role of astroglial gap juncton in the regulation of chronic painPrincipal Investigator

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The modulation of pain transduction mechanism through circadian clockPrincipal Investigator

Morioka Norimitsu 森岡徳光

MORIOKA Norimitsu 森岡徳光