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UCHIDA Hiroaki  内田 宏昭

ORCIDConnect your ORCID iD *help
Researcher Number 20401250
Affiliation (Current) 2022: 東京大学, 医科学研究所, 特任准教授
Affiliation (based on the past Project Information) *help 2018 – 2022: 東京大学, 医科学研究所, 特任准教授
2014 – 2017: 東京大学, 医科学研究所, 講師
2011 – 2013: 東京薬科大学, 生命科学部, 准教授
Review Section/Research Field
Principal Investigator
Basic Section 50020:Tumor diagnostics and therapeutics-related / Clinical oncology / Tumor therapeutics / Virology / Medium-sized Section 50:Oncology and related fields
Except Principal Investigator
General surgery / Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 53030:Respiratory medicine-related / Clinical oncology / Tumor therapeutics / Biological pharmacy
Keywords
Principal Investigator
がん / ヘルペスウイルス / 遺伝子治療 / 腫瘍溶解性ウイルス療法 / 抗体 / 腫瘍溶解ウイルス療法 / 癌 / 単純ヘルペスウイルス / 抗体医薬 / 癌標的化治療 / 造血器腫瘍 … More
Except Principal Investigator
… More イミュノトキシン / モノクローナル抗体 / DT3C / がん免疫療法 / ADC / ADC型抗体薬 / 遺伝子治療 / 免疫チェックポイント / MFG-E8 / 抗体 / AML / 標的治療 / HF10 / 腫瘍溶解性ウイルス / 悪性黒色腫 / ヒッチハイクメソッド / リンパ球療法 / Drug delivery / EGFR阻害薬耐性細胞株 / 抗体スクリーニング / 内在化 / EGFR阻害薬耐性 / 抗体結合型トキシンタンパク質 / ヘルペスウイルス / 遺伝子発現 / インシュレーター / 無毒化 / 神経特異的 / 神経特異的遺伝子発現 / 神経細胞特異的遺伝子発現 / UL41 / ウィルス / ゲノム / 脳・神経 / 薬学 / 発現制御 / 腫瘍免疫 / 腫瘍溶解性ウイルス療法 / 実験外科学 / 癌 / 免疫 / 遺伝子 / トランスレーショナルリサーチ / 生体機能利用 / PD-L1 / PD-L2 / 抗がん剤 / 化学免疫併用療法 / 高性能イミュノトキシン / 肺上皮前駆/幹細胞 / 選択な培養 / 慢性閉塞性肺疾患の治療 / 選択的培養 / 肺上皮幹細胞 / 選択的培養法 / 選択的な培養 / 特発性肺線維症の治療 / マクロファージ / 小細胞肺がん / SCLC Less
  • Research Projects

    (15 results)
  • Research Products

    (65 results)
  • Co-Researchers

    (28 People)
  •  膜融合能増強型標的化ヘルペスウイルスのさらなる改変による抗腫瘍免疫誘導能の増強Principal Investigator

    • Principal Investigator
      内田 宏昭
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      The University of Tokyo
  •  化学療法により誘導される免疫認識シグナル規定機構の解明と化学免疫併用療法への応用

    • Principal Investigator
      植松 美影 (濱田美影)
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      The University of Tokyo
  •  高性能イミュノトキシンを用いた小細胞肺がんの標的化治療法の開発

    • Principal Investigator
      山口 美樹
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53030:Respiratory medicine-related
    • Research Institution
      Sapporo Medical University
  •  Treatment of metastatic tumors by systemic injection of tumor-retargeted oncolytic herpesvirusesPrincipal Investigator

    • Principal Investigator
      Uchida Hiroaki
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      The University of Tokyo
  •  Development of oncolytic herpes simplex virus vectors retargeted to hematological malignanciesPrincipal Investigator

    • Principal Investigator
      Uchida Hiroaki
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 50:Oncology and related fields
    • Research Institution
      The University of Tokyo
  •  Molecular mechanism of chemotherapy-induced immunosuppressive proteins expressions in esophageal cancer cells.

    • Principal Investigator
      Mika Hamada-Uematsu
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      The University of Tokyo
  •  Development of a selective culture method for pulmonary epithelial stem cells using high-performance immunotoxin

    • Principal Investigator
      Yamaguchi Miki
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53030:Respiratory medicine-related
    • Research Institution
      Sapporo Medical University
  •  Development of cancer immunotherapy using hyperfusogenic receptor-retargeted HSV

    • Principal Investigator
      TAHARA HIDEAKI
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      General surgery
    • Research Institution
      The University of Tokyo
  •  Development of non-toxic herpes simplex virus vectors for neural-specific gene delivery

    • Principal Investigator
      Yoshitaka Miyagawa
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Nippon Medical School
  •  Generation of immunotoxins with super-targeting mAb in the EGFR-mutant lung adenocarcinoma

    • Principal Investigator
      YAMAGUCHI MIKI
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Tumor therapeutics
    • Research Institution
      Sapporo Medical University
  •  Development of highly specific oncolytic herpes virus vectors by modification of two envelope glycoproteinsPrincipal Investigator

    • Principal Investigator
      Uchida Hiroaki
    • Project Period (FY)
      2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Virology
    • Research Institution
      The University of Tokyo
  •  Augmentation of tumor specificity and killing activity of oncolytic herpes virus vectorsPrincipal Investigator

    • Principal Investigator
      Uchida Hiroaki
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Tumor therapeutics
    • Research Institution
      The University of Tokyo
      Tokyo University of Pharmacy and Life Science
  •  Systemic virotherapy using oncolytic herpes simplex virus adsorbed onto antigen-specific lymphocytes

    • Principal Investigator
      KASUYA Hideki
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General surgery
    • Research Institution
      Nagoya University
  •  Generation of immunotoxins with super-targeting mAb in the acute myelocytic leukemia

    • Principal Investigator
      YAMAGUCHI MIKI
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Clinical oncology
    • Research Institution
      Sapporo Medical University
  •  Application of in-house monoclonal antibody resources to a fully retargeted oncolytic herpes simplex virus platformPrincipal Investigator

    • Principal Investigator
      UCHIDA Hiroaki
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Clinical oncology
    • Research Institution
      Tokyo University of Pharmacy and Life Science

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Patent

  • [Journal Article] Potent anti-tumor effects of receptor-retargeted syncytial oncolytic herpes simplex virus2021

    • Author(s)
      Suzuki Takuma、Uchida Hiroaki、Shibata Tomoko、Sasaki Yasuhiko、Ikeda Hitomi、Hamada-Uematsu Mika、Hamasaki Ryota、Okuda Kosaku、Yanagi Shigeru、Tahara Hideaki
    • Journal Title

      Molecular Therapy - Oncolytics

      Volume: 22 Pages: 265-276

    • DOI

      10.1016/j.omto.2021.08.002

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07319
  • [Journal Article] Antibody Screening System Using a Herpes Simplex Virus (HSV)-Based Probe To Identify a Novel Target for Receptor-Retargeted Oncolytic HSVs2021

    • Author(s)
      Hitomi Ikeda, Hiroaki Uchida, Yu Okubo, Tomoko Shibata, Yasuhiko Sasaki, Takuma Suzuki, Mika Hamada -Uematsu, Ryota Hamasaki, Kosaku Okuda, Miki Yamaguchi, Masaki Kojima, Masato Tanaka, Hirofumi Hamada, Hideaki Tahara
    • Journal Title

      Journal of Virology

      Volume: 95

    • DOI

      10.1128/jvi.01766-20

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07319, KAKENHI-PROJECT-18H02687
  • [Journal Article] Immuno-regulatory influence of abundant MFG-E8 expression by esophageal cancer treated with chemotherapy.2018

    • Author(s)
      Kanemura Takashi、Miyata Hiroshi、Makino Tomoki、Tanaka Koji、Sugimura Keijiro、Hamada-Uematsu Mika、Mizote Yu、Uchida Hiroaki、Miyazaki Yasuhiro、Takahashi Tsuyoshi、Kurokawa Yukinori、Yamasaki Makoto、Wada Hisashi、Nakajima Kiyokazu、Takiguchi Shuji、Mori Masaki、Doki Yuichiro、Tahara Hideaki
    • Journal Title

      Cancer Science

      Volume: 109 Pages: 224-228

    • DOI

      10.1111/cas.13785

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07319, KAKENHI-PROJECT-17H01578
  • [Journal Article] Oncolytic Herpes Simplex Virus Vectors Fully Retargeted to Tumor- Associated Antigens2018

    • Author(s)
      Uchida Hiroaki、Hamada Hirofumi、Nakano Kenji、Kwon Heechung、Tahara Hideaki、Cohen Justus B.、Glorioso Joseph C.
    • Journal Title

      Current Cancer Drug Targets

      Volume: 18 Pages: 162-170

    • DOI

      10.2174/1568009617666170206105855

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08249
  • [Journal Article] Deletion of the Virion Host Shut-off Gene Enhances Neuronal-Selective Transgene Expression from an HSV Vector Lacking Functional IE Genes2017

    • Author(s)
      Miyagawa Yoshitaka、Verlengia Gianluca、Reinhart Bonnie、Han Fang、Uchida Hiroaki、Zucchini Silvia、Goins William F.、Simonato Michele、Cohen Justus B.、Glorioso Joseph C.
    • Journal Title

      Molecular Therapy - Methods & Clinical Development

      Volume: 6 Pages: 79-90

    • DOI

      10.1016/j.omtm.2017.06.001

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08249
  • [Journal Article] Antiglycopeptide Mouse Monoclonal Antibody LpMab-21 Exerts Antitumor Activity Against Human Podoplanin Through Antibody-Dependent Cellular Cytotoxicity and Complement-Dependent Cytotoxicity2017

    • Author(s)
      Kato Y, Kunita A, Fukayama M, Abe S, Nishioka Y, Uchida H, Tahara H, Yamada S,Yanaka M, Nakamura T, Saidoh N, Yoshida K, Fujii Y, Honma R, Takagi M, Ogasawara S, Murata T, Kaneko MK.
    • Journal Title

      Monoclon Antib Immunodiagn Immunother

      Volume: 36(1) Pages: 20-24

    • DOI

      10.1089/mab.2016.0045

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26440019, KAKENHI-PROJECT-17H01578, KAKENHI-PROJECT-16H05309, KAKENHI-PROJECT-15K10459
  • [Journal Article] Angiotensin-converting enzyme 2 is a potential therapeutic target for EGFR-mutant lung adenocarcinoma2017

    • Author(s)
      Yamaguchi M, Hirai S, Sumi T, Tanaka Y, Tada M, Nishii Y, Hasegawa T, Uchida H, Yamada G, Watanabe A, Takahashi H, Sakuma Y.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 487(3) Pages: 613-618

    • DOI

      10.1016/j.bbrc.2017.04.102

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K06876, KAKENHI-PROJECT-15K08364
  • [Journal Article] Chimeric Anti-Human Podoplanin Antibody NZ-12 of Lambda Light Chain Exerts Higher Antibody-Dependent Cellular Cytotoxicity and Complement-Dependent Cytotoxicity Compared with NZ-8 of Kappa Light Chain2017

    • Author(s)
      Kaneko MK, Abe S, Ogasawara S, Fujii Y, Yamada S, Murata T, Uchida H, Tahara H, Nishioka Y, Kato Y.
    • Journal Title

      Monoclon Antib Immunodiagn Immunothe

      Volume: 36(1) Pages: 25-29

    • DOI

      10.1089/mab.2016.0047

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26440019, KAKENHI-PROJECT-17H01578, KAKENHI-PROJECT-16H05309
  • [Journal Article] Development of an oncolytic HSV vector fully retargeted specifically to cellular EpCAM for virus entry and cell-to-cell spread.2016

    • Author(s)
      Shibata T, Uchida H, Shiroyama T, Okubo Y, Suzuki T, Ikeda H, Yamaguchi M, Miyagawa Y, Fukuhara T, Cohen JB, Glorioso JC, Watabe T, Hamada H, Tahara H.
    • Journal Title

      Gene Ther.

      Volume: 印刷中 Pages: 479-488

    • DOI

      10.1038/gt.2016.17

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15144, KAKENHI-PROJECT-25290059, KAKENHI-PROJECT-15K06876, KAKENHI-PROJECT-16K08249
  • [Journal Article] Syncytial Mutations Do Not Impair the Specificity of Entry and Spread of a Glycoprotein D Receptor-Retargeted Herpes Simplex Virus.2016

    • Author(s)
      Okubo Y, Uchida H, Wakata A, Suzuki T, Shibata T, Ikeda H, Yamaguchi M, Cohen JB, Glorioso JC, Tagaya M, Hamada H, Tahara H.
    • Journal Title

      J Virol.

      Volume: Nov28;90(24) Pages: 11096-11105

    • DOI

      10.1128/jvi.01456-16

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K06876, KAKENHI-PROJECT-16K08249
  • [Journal Article] 大腸癌の遺伝子治療・ウイルス療法2015

    • Author(s)
      内田宏昭, 田原秀晃
    • Journal Title

      日本臨床

      Volume: 1077 Pages: 569-573

    • Data Source
      KAKENHI-PROJECT-25290059
  • [Journal Article] Use of miRNA response sequences to block off-target replication and increase the safety of an unattenuated, glioblastoma-targeted oncolytic HSV.2015

    • Author(s)
      Mazzacurati L, Marzulli M, Reinhart B, Miyagawa Y, Uchida H, Goins WF, Li A, Kaur B, Caligiuri M, Cripe T, Chiocca N, Amankulor N, Cohen JB, Glorioso JC, Grandi P.
    • Journal Title

      Molecular Therapy.

      Volume: 23 Pages: 99-107

    • DOI

      10.1038/mt.2014.177

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25290059
  • [Journal Article] Herpes simplex viral-vector design for efficient transduction of nonneuronal cells without cytotoxicity.2015

    • Author(s)
      Miyagawa Y, Marino P, Verlengia G, Uchida H, Goins WF, Yokota S, Geller DA, Yoshida O, Mester J, Cohen JB, Glorioso JC.
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America.

      Volume: 112

    • DOI

      10.1073/pnas.1423556112

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25290059
  • [Journal Article] A newly developed anti-Mucin 13 monoclonal antibody targets pancreatic ductal adenocarcinoma cells.2015

    • Author(s)
      Nishii Y, Yamaguchi M, Kimura Y, Hasegawa T, Aburatani H, Uchida H, Hirata K, Sakuma Y.
    • Journal Title

      International Journal of Oncology.

      Volume: 46 Pages: 1781-1787

    • DOI

      10.3892/ijo.2015.2880

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K15144, KAKENHI-PROJECT-25290059
  • [Journal Article] 大腸癌の遺伝子治療・ウイルス療法2015

    • Author(s)
      内田宏昭, 田原秀晃
    • Journal Title

      日本臨床

      Volume: 1077 Pages: 569-573

    • Data Source
      KAKENHI-PROJECT-15K15144
  • [Journal Article] Development of a sensitive screening method for selecting monoclonal antibodies to be internalized by cells.2014

    • Author(s)
      Yamaguchi M, Nishii Y, Nakamura K, Aoki H, Hirai S, Uchida H, Sakuma Y, Hamada H.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 454 Pages: 600-603

    • DOI

      10.1016/j.bbrc.2014.10.133

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25290059, KAKENHI-PROJECT-26462831
  • [Journal Article] Development of a novel efficient method to construct an adenovirus library displaying random peptides on the fiber knob.2014

    • Author(s)
      Yamamoto Y, Goto N, Miura K, Narumi K, Ohnami S, Uchida H, Miura Y, Yamamoto M, Aoki K.
    • Journal Title

      Molecular Pharmaceutics

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25290059
  • [Journal Article] A targeting ligand enhances infectivity and cytotoxicity of an oncolytic adenovirus in human pancreatic cancer tissues.2014

    • Author(s)
      Yamamoto Y, Hiraoka N, Goto N, Rin Y, Miura K, Narumi K, Uchida H, Tagawa M, Aoki K.
    • Journal Title

      Journal of Control Release.

      Volume: 192 Pages: 284-293

    • DOI

      10.1016/j.jconrel.2014.07.053

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25290059
  • [Journal Article] Expression of HSV-1 receptors in EBV-associated lymphoproliferative disease determines susceptibility to oncolytic HSV2013

    • Author(s)
      Wang PY, Currier MA, Hansford L, Kaplan D, Chiocca EA, Uchida H, Goins WF, Cohen JB, Glorioso JC, van Kuppevelt TH, Mo X, Cripe TP
    • Journal Title

      Gene Ther

      Volume: 20(7) Pages: 761-769

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23501309
  • [Journal Article] Expression of HSV-1 receptors in EBV-associated lymphoproliferative disease determines susceptibility to oncolytic HSV.2013

    • Author(s)
      Wang PY, Currier MA, Hansford L, Kaplan D, Chiocca EA, Uchida H, Goins WF, Cohen JB, Glorioso JC, Kuppevelt TH, Mo X, Cripe TP.
    • Journal Title

      Gene Therapy

      Volume: 20 Pages: 761-769

    • DOI

      10.1038/gt.2012.93

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25290059
  • [Journal Article] Novel mutations in gB and gH circumvent the requirement for known gD receptors in HSV-1 entry and cell-to-cell spread2013

    • Author(s)
      Uchida H, Chan J, Shrivastava I, Reinhart B, Grandi P, Glorioso JC, Cohen JB
    • Journal Title

      J Virol

      Volume: 87(3) Pages: 1430-42

    • Data Source
      KAKENHI-PROJECT-23800058
  • [Journal Article] Effective treatment of an orthotopic xenograft model of human glioblastoma using an EGFR-retargeted oncolytic herpes simplex virus.2013

    • Author(s)
      Uchida H, Marzulli M, Nakano K, Goins WF, Chan J, Hong CS, Mazzacurati L, Yoo JY, Haseley A, Nakashima H, Baek H, Kwon H, Kumagai I, Kuroki M, Kaur B, Chiocca EA, Grandi P, Cohen JB, Glorioso JC.
    • Journal Title

      Molecular Therapy

      Volume: 21 Pages: 561-569

    • DOI

      10.1038/mt.2012.211

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25290059
  • [Journal Article] Effective treatment of an orthotopic xenograft model of human glioblastoma using an EGFR-retargeted oncolytic herpes simplex virus2013

    • Author(s)
      Uchida H, Marzulli M, Nakano K, Goins WF, Chan J, Hong CH, Mazzacurati L, Yoo JY, Haseley A, Nakashima H, Baek H, Kwon H, Kumagai I, Kuroki M, Kaur B, Chiocca EA, Grandi P, Cohen JB, Glorioso JC
    • Journal Title

      Mol Ther

      Volume: 21(3) Pages: 561-9

    • Data Source
      KAKENHI-PROJECT-23800058
  • [Journal Article] Novel mutations in gB and gH circumvent the requirement for known gD receptors in HSV-1 entry and cell-to-cell spread2013

    • Author(s)
      Uchida H, Chan J, Shrivastava I, Reinhart B, Grandi P, Glorioso JC, Cohen JB
    • Journal Title

      J Virol

      Volume: 87(3) Pages: 1430-1442

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23501309
  • [Journal Article] Effective treatment of an orthotopic xenograft model of human glioblastoma using an EGFR-retargeted oncolytic herpes simplex virus2013

    • Author(s)
      Uchida H, Marzulli M, Nakano K, Goins WF, Chan J, Hong CH, Mazzacurati L, Yoo JY, Haseley A, Nakashima H, Baek H, Kwon H, Kumagai I, Kuroki M, Kaur B, Chiocca EA, Grandi P, Cohen JB, Glorioso JC
    • Journal Title

      Mol Ther

      Volume: 21(3) Pages: 561-569

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23501309
  • [Journal Article] Novel mutations in gB and gH circumvent the requirement for known gD receptors in HSV-1 entry and cell-to-cell spread.2013

    • Author(s)
      Uchida H, Chan J, Shrivastava I, Reinhart B, Grandi P, Glorioso JC, Cohen JB.
    • Journal Title

      Journal of Virology

      Volume: 87 Pages: 1430-1442

    • DOI

      10.1128/jvi.02804-12

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25290059
  • [Journal Article] Bispecific adapter-mediated retargeting of a receptor-restricted HSV-1 vector to CEA-bearing tumor cells2011

    • Author(s)
      Baek H, Uchida H, Jun K, Kim JH, Kuroki M, Cohen JB, Glorioso JC, Kwon H
    • Journal Title

      Mol Ther

      Volume: 19(3) Pages: 507-14

    • DOI

      10.1038/mt.2010.207

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23800058
  • [Journal Article] Expression of HSV-1 receptors in EBV-associated lymphoproliferative disease determines susceptibility to oncolytic HSV

    • Author(s)
      Wang PY, Currier MA, Hansford L, Kaplan D, Chiocca EA, Uchida H, Goins WF, Cohen JB, Glorioso JC, Kuppevelt TH, Mo X, Cripe TP
    • Journal Title

      Gene Ther

      Volume: (in press)

    • Data Source
      KAKENHI-PROJECT-23800058
  • [Patent] ONCOLYTIC HSV VECTOR (divisional)2021

    • Inventor(s)
      Hiroaki Uchidaら
    • Industrial Property Rights Holder
      Hiroaki Uchidaら
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18H02687
  • [Patent] ONCOLYTIC HSV VECTOR (continuation)2020

    • Inventor(s)
      Hiroaki Uchidaら
    • Industrial Property Rights Holder
      Hiroaki Uchidaら
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18H02687
  • [Patent] ONCOLYTIC HSV VECTOR (divisional)2020

    • Inventor(s)
      Hiroaki Uchidaら
    • Industrial Property Rights Holder
      Hiroaki Uchidaら
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18H02687
  • [Patent] がん治療のための腫瘍溶解性ウイルス2019

    • Inventor(s)
      内田宏昭・田原秀晃
    • Industrial Property Rights Holder
      内田宏昭・田原秀晃
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18H02687
  • [Patent] がん治療のための腫瘍溶解性ウイルス2019

    • Inventor(s)
      内田宏昭・田原秀晃
    • Industrial Property Rights Holder
      内田宏昭・田原秀晃
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18K19468
  • [Presentation] 高性能イミュノトキシンを用いた小細胞肺がんに対する標的の探索2021

    • Author(s)
      山口美樹、藤谷直樹、平井幸恵、高橋素子、内田宏昭、佐久間裕司
    • Organizer
      第123回北海道癌談話会例会
    • Data Source
      KAKENHI-PROJECT-21K08161
  • [Presentation] 新規ウイルス産生細胞を用いた無毒化ヘルペスウイルスベクターの生産系の確立.2017

    • Author(s)
      黒田 誠司、宮川 世志幸、足立 久美、山本 基子、Cohen Justus B.、Glorioso Joseph C.、鈴木 英之、内田 英二、岡田 尚巳.
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Data Source
      KAKENHI-PROJECT-16K08249
  • [Presentation] がん細胞のみに侵入可能な標的化改変ヘルペスウイルスの開発2016

    • Author(s)
      内田宏昭
    • Organizer
      第116回日本外科学会定期学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2016-04-14
    • Data Source
      KAKENHI-PROJECT-15K15144
  • [Presentation] がん細胞のみに侵入可能な標的化改変ヘルペスウイルスの開発2016

    • Author(s)
      内田宏昭
    • Organizer
      第116回日本外科学会定期学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2016-04-14
    • Data Source
      KAKENHI-PROJECT-25290059
  • [Presentation] がん細胞表面抗原を介して細胞内侵入する標的化改変単純ヘルペスウイルスベクターの開発2015

    • Author(s)
      内田宏昭
    • Organizer
      第56回日本臨床ウイルス学会
    • Place of Presentation
      岡山大学鹿田キャンパス(岡山県岡山市)
    • Year and Date
      2015-06-13
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K15144
  • [Presentation] Exploration of cancer-targeting antibodies using an HSV-based screening system for development of novel HSV vectors fully retargeted to cancer cells.2015

    • Author(s)
      内田宏昭
    • Organizer
      The 21th Annual Meeting of Japan Society of Gene Therapy.
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2015-07-24
    • Data Source
      KAKENHI-PROJECT-25290059
  • [Presentation] 腫瘍細胞表面抗原を介して侵入する標的化単純ヘルペスウイルスベクターの開発2015

    • Author(s)
      城山智貴, 内田宏昭, 大久保優, 柴田智子, 福原武志, 山口美樹, Justus B. Cohen, Joseph C. Glorioso, 渡部徹郎, 濱田洋文, 田原秀晃
    • Organizer
      第7回血液疾患免疫療法研究会
    • Place of Presentation
      東京大学本郷キャンパス(東京都文京区)
    • Year and Date
      2015-09-26
    • Data Source
      KAKENHI-PROJECT-15K15144
  • [Presentation] Exploration of cancer-targeting antibodies using an HSV-based screening system for development of novel HSV vectors fully retargeted to cancer cells.2015

    • Author(s)
      内田宏昭
    • Organizer
      The 21th Annual Meeting of Japan Society of Gene Therapy.
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2015-07-24
    • Data Source
      KAKENHI-PROJECT-15K15144
  • [Presentation] 腫瘍細胞表面抗原を介して侵入する標的化単純ヘルペスウイルスベクターの開発2015

    • Author(s)
      城山智貴, 内田宏昭, 大久保優, 柴田智子, 福原武志, 山口美樹, Justus B. Cohen, Joseph C. Glorioso, 渡部徹郎, 濱田洋文, 田原秀晃
    • Organizer
      第7回血液疾患免疫療法研究会
    • Place of Presentation
      東京大学本郷キャンパス(東京都文京区)
    • Year and Date
      2015-09-26
    • Data Source
      KAKENHI-PROJECT-25290059
  • [Presentation] がん細胞表面抗原を介して細胞内侵入する標的化改変単純ヘルペスウイルスベクターの開発2015

    • Author(s)
      内田宏昭
    • Organizer
      第56回日本臨床ウイルス学会
    • Place of Presentation
      岡山大学鹿田キャンパス(岡山県岡山市)
    • Year and Date
      2015-06-13
    • Invited
    • Data Source
      KAKENHI-PROJECT-25290059
  • [Presentation] Application of in-house monoclonal antibody resources to a fully retargeted oncolytic herpes simplex virus platform2013

    • Author(s)
      Yu Okubo1, Takuma Suzuki1, Tomoko Shibata1, Mao Komai1, Takeshi Fukuhara1, Miki Yamaguchi2, Sachie Hirai2, Yoshitaka Miyagawa3, Justus B. Cohen3, Joseph C. Glorioso3, Hirofumi Hamada1, and Hiroaki Uchida1
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23501309
  • [Presentation] Syncytial mutations augment the oncolytic potential of a fully retargeted herpes simplex virus vector.2013

    • Author(s)
      Wakata A, Okubo Y, Fukuhara T, Cohen JB, Joseph C. Glorioso JC, Nakano K, Kumagai I, Kuroki M, Hamada H, Uchida H.
    • Organizer
      The 19th Annual Meeting of Japan Society of Gene Therapy.
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-25290059
  • [Presentation] Establishment of highly functional monoclonal antibodies through novel screening methods for targeted cancer therapy2013

    • Author(s)
      Moegi Sato1, Miki Yamaguchi2, Hitomi Ikeda1, Yuta Matsuura1, Takeshi Fukuhara1, Hirofumi Hamada1, and Hiroaki Uchida1
    • Organizer
      第81回日本生化学会大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23501309
  • [Presentation] 白血病/リンパ腫に対するスーパー標的化抗体を用いたイムノトキシンの開発2013

    • Author(s)
      西井ゆかり、山口美樹、平井幸恵、内田宏昭、濱田洋
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2013-10-03
    • Data Source
      KAKENHI-PROJECT-23501309
  • [Presentation] エンベロープ糖タンパクgDにがん標的化単鎖抗体を挿入した単純ヘルペスウイルスを用いた腫瘍溶解ウイルス療法の開発2013

    • Author(s)
      鈴木拓真, 柴田智子, 大久保優, 福原武志, 宮川世志幸, Justus Cohen, Joseph Glorioso, 中野賢二, 熊谷泉, 黒木政秀, 山口美樹, 平井幸恵, 濱田洋文, 内田宏昭
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-25290059
  • [Presentation] 単純ヘルペスウイルスの標的化改変プラットフォームへのがん標的化抗体インハウスリソースの適用2013

    • Author(s)
      柴田智子, 鈴木拓真, 大久保優, 駒井麻央, 福原武志, 山口美樹, 平井幸恵, 宮川世志幸, Justus Cohen, Joseph Glorioso, 濱田洋文, 内田宏昭
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-25290059
  • [Presentation] Application of monoclonal antibody resources to a fully retargeted HSV platform2013

    • Author(s)
      Tomoko Shibata1, Takuma Suzuki1, Yu Okubo1, Mao Komai1, Takeshi Fukuhara1, Miki Yamaguchi2, Sachie Hirai2, Yoshitaka Miyagawa3, Justus B. Cohen3, Joseph C. Glorioso3, Hirofumi Hamada1, and Hiroaki Uchida1
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-23501309
  • [Presentation] Manipulation of multiple herpes simplex virus glycoproteins for fully retargeted entry and efficient cell-to-cell spread.2013

    • Author(s)
      Wakata A, Okubo Y, Fukuhara T, Cohen JB, Glorioso JC, Nakano K, Kumagai I, Kuroki M, Hamada H, Uchida H.
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-25290059
  • [Presentation] Development of fully retargeted oncolytic herpes simplex virus vectors by insertion of tumor-specific single-chain antibodies into viral envelope glycoprotein D2013

    • Author(s)
      Takuma Suzuki1, Tomoko Shibata1, Yu Okubo1, Takeshi Fukuhara1, Yoshitaka Miyagawa2, Justus B. Cohen2, Joseph C. Glorioso2, Kenji Nakano3, Izumi Kumagai4, Masahide Kuroki5, Miki Yamaguchi6, Sachie Hirai6, Hirofumi Hamada1, and Hiroaki Uchida1
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-23501309
  • [Presentation] Generation of immunotoxins with super-targeting mAb in the leukemia/lymphoma2013

    • Author(s)
      Yukari Nishii1, Miki Yamaguchi1, Hiroaki Uchida2, Hirofumi Hamada1,2
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23501309
  • [Presentation] Application of in-house monoclonal antibody resources to a fully retargeted oncolytic herpes simplex virus platform.2013

    • Author(s)
      Okubo Y, Suzuki T, Shibata T, Komai M, Fukuhara T, Yamaguchi M, Hirai S, Miyagawa Y, Cohen JB, Glorioso JC, Hamada H, Uchida H.
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-25290059
  • [Presentation] 高性能癌標的化抗体の網羅的探索と標的化ヘルペスウイルスベクター系の完成2012

    • Author(s)
      内田宏昭
    • Organizer
      バイオテック2012アカデミックフォーラム
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23800058
  • [Presentation] 標的化ヘルペスウイルスでがんを狙い撃ち-エンベロープ糖タンパクの遺伝子工学的改変2012

    • Author(s)
      内田宏昭、濱田洋文、Justus B. Cohen、Joseph C. Glorioso
    • Organizer
      第2回医薬工3大学包括連携推進シンポジウム
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23800058
  • [Presentation] Fully retargeted herpes simplex virus vector by co-engineering of viral glycoproteins2011

    • Author(s)
      Uchida H
    • Organizer
      The 17th Annual Meeting of the Japan Society of Gene Therapy
    • Place of Presentation
      Fukuoka, Japan
    • Data Source
      KAKENHI-PROJECT-23800058
  • [Presentation] Fully retargeted herpes simplex virus vector by co-engineering of viral glycoproteins2011

    • Author(s)
      Uchida, H
    • Organizer
      The 17th Annual Meeting of Japan Society of Gene Therapy
    • Place of Presentation
      Hakata, Japan
    • Data Source
      KAKENHI-PROJECT-23800058
  • [Presentation] 単純ヘルペスウイルスのターゲティング-2種類のウイルス糖タンパクの同時改変2011

    • Author(s)
      内田宏昭, 中野賢二, Chang-Sook Hong, William Goins, Janet Chan, Heechung Kwon, 熊谷泉, 黒木政秀, Justus Cohen, Joseph Glorioso
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-23800058
  • [Presentation] 腫瘍細胞のみに感染可能な標的化ヘルペスウイルスベクターの実現2011

    • Author(s)
      内田宏昭, Justus Cohen, Joseph Glorioso
    • Organizer
      第111回日本外科学会定期学術集会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23800058
  • [Presentation] 腫瘍細胞のみに感染可能な標的化ヘルペスウイルスベクターの実現2011

    • Author(s)
      内田宏昭, Justus Cohen, Joseph Glorioso
    • Organizer
      第111回日本外科学会定期学術集会
    • Place of Presentation
      東京(紙上開催)
    • Data Source
      KAKENHI-PROJECT-23800058
  • [Presentation] Exploration of cancer-targeting antibodies using an HSV-based screening system.

    • Author(s)
      Okubo Y, Ikeda H, Fukuhara T, Kojima M, Cohen JB, Glorioso JC, Hamada H, Watabe T, Uchida H.
    • Organizer
      The 39th International Herpesvirus Workshop.
    • Place of Presentation
      神戸コンベンションセンター(兵庫県神戸市)
    • Year and Date
      2014-07-19 – 2014-07-23
    • Data Source
      KAKENHI-PROJECT-25290059
  • [Presentation] Development of a new generation of herpes simplex virus vectors fully retargeted to a variety of tumor-associated antigens.

    • Author(s)
      Uchida H, Okubo Y, Shibata T, Suzuki T, Ikeda H, Shiroyama T, Fukuhara T, Kojima M, Yamaguchi M, Miyagawa Y, Cohen JB, Glorioso JC, Hamada H.
    • Organizer
      The 20th Annual Meeting of Japan Society of Gene Therapy.
    • Place of Presentation
      東京慈恵会医科大学(東京都港区)
    • Year and Date
      2014-08-06 – 2014-08-08
    • Data Source
      KAKENHI-PROJECT-25290059
  • [Presentation] Augmentation of oncolytic potential of a fully retargeted HSV vector by introduction of syncytial mutations.

    • Author(s)
      Wakata A, Okubo Y, Fukuhara T, Cohen JB, Glorioso JC, Nakano K, Kumagai I, Kuroki M, Hamada H, Watabe T, Uchida H.
    • Organizer
      The 39th International Herpesvirus Workshop.
    • Place of Presentation
      神戸コンベンションセンター(兵庫県神戸市)
    • Year and Date
      2014-07-19 – 2014-07-23
    • Data Source
      KAKENHI-PROJECT-25290059
  • [Presentation] Generation of an EpCAM-retargeted HSV vector by application of in-house monoclonal antibody resources.

    • Author(s)
      Shibata T, Shiroyama T, Suzuki T, Okubo Y, Fukuhara T, Yamaguchi M, Miyagawa Y, Cohen JB, Glorioso JC, Hamada H, Watabe T, Uchida H.
    • Organizer
      The 39th International Herpesvirus Workshop.
    • Place of Presentation
      神戸コンベンションセンター(兵庫県神戸市)
    • Year and Date
      2014-07-19 – 2014-07-23
    • Data Source
      KAKENHI-PROJECT-25290059
  • 1.  TAHARA HIDEAKI (70322071)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 10 results
  • 2.  YAMAGUCHI MIKI (10530454)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 19 results
  • 3.  Mika Hamada-Uematsu (90769449)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 3 results
  • 4.  佐久間 裕司 (10364514)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 5.  高橋 素子 (00303941)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 6.  藤谷 直樹 (10374191)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 7.  HAMADA Hirofumi (00189614)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 8.  HIRAI Sachie (20218754)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 9.  FUKUHARA TAKESHI (20359673)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 11 results
  • 10.  KASUYA Hideki (00402636)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  KODERA Yasuhiro (10345879)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  YAMADA Suguru (30467287)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  SHIKU Hiroshi (80154194)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  NOMOTO Shuji (40300967)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  KOJIMA MASAKI (90277252)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  Yoshitaka Miyagawa (90415604)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 17.  西井 ゆかり (10619505)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  土岐 祐一郎 (20291445)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 19.  田中 晃司 (70621019)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 20.  角 俊行 (60772291)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  田中 悠祐 (70792125)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  多田 周 (00815441)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  Glorioso Joseph C., III
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 24.  KUNITA Akiko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 25.  中村 公則
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 26.  金子 美華
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 27.  西岡 安彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 28.  高木 理彰
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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