Uchida Hiroaki 内田宏昭

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UCHIDA Hiroaki 内田宏昭

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Researcher Number	20401250
Affiliation (Current)	2023: 東京薬科大学, その他部局等, 特命教授
Affiliation (based on the past Project Information) *help	2023: 東京薬科大学, その他部局等, 特命教授 2018 – 2022: 東京大学, 医科学研究所, 特任准教授 2014 – 2017: 東京大学, 医科学研究所, 講師 2011 – 2013: 東京薬科大学, 生命科学部, 准教授
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Clinical oncology / Tumor therapeutics / Virology / Medium-sized Section 50:Oncology and related fields Except Principal Investigator General surgery / Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 53030:Respiratory medicine-related / Clinical oncology / Tumor therapeutics / Biological pharmacy
Keywords	Principal Investigator がん / ヘルペスウイルス / 遺伝子治療 / 腫瘍溶解性ウイルス療法 / 抗体 / 腫瘍溶解ウイルス療法 / 癌 / 単純ヘルペスウイルス / 抗体医薬 / 癌標的化治療 / 造血器腫瘍 … More Except Principal Investigator … More イミュノトキシン / モノクローナル抗体 / DT3C / がん免疫療法 / ADC / ADC型抗体薬 / 遺伝子治療 / 免疫チェックポイント / MFG-E8 / 抗体 / AML / 標的治療 / HF10 / 腫瘍溶解性ウイルス / 悪性黒色腫 / ヒッチハイクメソッド / リンパ球療法 / Drug delivery / EGFR阻害薬耐性細胞株 / 抗体スクリーニング / 内在化 / EGFR阻害薬耐性 / 抗体結合型トキシンタンパク質 / ヘルペスウイルス / 遺伝子発現 / インシュレーター / 無毒化 / 神経特異的 / 神経特異的遺伝子発現 / 神経細胞特異的遺伝子発現 / UL41 / ウィルス / ゲノム / 脳・神経 / 薬学 / 発現制御 / 腫瘍免疫 / 腫瘍溶解性ウイルス療法 / 実験外科学 / 癌 / 免疫 / 遺伝子 / トランスレーショナルリサーチ / 生体機能利用 / PD-L1 / PD-L2 / 抗がん剤 / 化学免疫併用療法 / 高性能イミュノトキシン / 肺上皮前駆/幹細胞 / 選択な培養 / 慢性閉塞性肺疾患の治療 / 選択的培養 / 肺上皮幹細胞 / 選択的培養法 / 選択的な培養 / 特発性肺線維症の治療 / マクロファージ / 小細胞肺がん / SCLC Less

膜融合能増強型標的化ヘルペスウイルスのさらなる改変による抗腫瘍免疫誘導能の増強Principal Investigator
- Principal Investigator
  
  内田宏昭
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
  The University of Tokyo
化学療法により誘導される免疫認識シグナル規定機構の解明と化学免疫併用療法への応用
- Principal Investigator
  
  植松美影 (濱田美影)
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  The University of Tokyo
高性能イミュノトキシンを用いた小細胞肺がんの標的化治療法の開発
- Principal Investigator
  
  山口美樹
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Sapporo Medical University
Treatment of metastatic tumors by systemic injection of tumor-retargeted oncolytic herpesvirusesPrincipal Investigator
- Principal Investigator
  
  Uchida Hiroaki
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  The University of Tokyo
Development of oncolytic herpes simplex virus vectors retargeted to hematological malignanciesPrincipal Investigator
- Principal Investigator
  
  Uchida Hiroaki
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  The University of Tokyo
Molecular mechanism of chemotherapy-induced immunosuppressive proteins expressions in esophageal cancer cells.
- Principal Investigator
  
  Mika Hamada-Uematsu
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  The University of Tokyo
Development of a selective culture method for pulmonary epithelial stem cells using high-performance immunotoxin
- Principal Investigator
  
  Yamaguchi Miki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Sapporo Medical University
Development of cancer immunotherapy using hyperfusogenic receptor-retargeted HSV
- Principal Investigator
  
  TAHARA HIDEAKI
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General surgery
- Research Institution
  The University of Tokyo
Development of non-toxic herpes simplex virus vectors for neural-specific gene delivery
- Principal Investigator
  
  Yoshitaka Miyagawa
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Nippon Medical School
Generation of immunotoxins with super-targeting mAb in the EGFR-mutant lung adenocarcinoma
- Principal Investigator
  
  YAMAGUCHI MIKI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Sapporo Medical University
Development of highly specific oncolytic herpes virus vectors by modification of two envelope glycoproteinsPrincipal Investigator
- Principal Investigator
  
  Uchida Hiroaki
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Virology
- Research Institution
  The University of Tokyo
Augmentation of tumor specificity and killing activity of oncolytic herpes virus vectorsPrincipal Investigator
- Principal Investigator
  
  Uchida Hiroaki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  The University of Tokyo
  Tokyo University of Pharmacy and Life Science
Systemic virotherapy using oncolytic herpes simplex virus adsorbed onto antigen-specific lymphocytes
- Principal Investigator
  
  KASUYA Hideki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Nagoya University
Generation of immunotoxins with super-targeting mAb in the acute myelocytic leukemia
- Principal Investigator
  
  YAMAGUCHI MIKI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical oncology
- Research Institution
  Sapporo Medical University
Application of in-house monoclonal antibody resources to a fully retargeted oncolytic herpes simplex virus platformPrincipal Investigator
- Principal Investigator
  
  UCHIDA Hiroaki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Clinical oncology
- Research Institution
  Tokyo University of Pharmacy and Life Science

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Patent

[Journal Article] Potent anti-tumor effects of receptor-retargeted syncytial oncolytic herpes simplex virus2021
- Author(s)
  Suzuki Takuma、Uchida Hiroaki、Shibata Tomoko、Sasaki Yasuhiko、Ikeda Hitomi、Hamada-Uematsu Mika、Hamasaki Ryota、Okuda Kosaku、Yanagi Shigeru、Tahara Hideaki
- Journal Title
  
  Molecular Therapy - Oncolytics
  
  Volume: 22 Pages: 265-276
- DOI
  10.1016/j.omto.2021.08.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07319
[Journal Article] Antibody Screening System Using a Herpes Simplex Virus (HSV)-Based Probe To Identify a Novel Target for Receptor-Retargeted Oncolytic HSVs2021
- Author(s)
  Hitomi Ikeda, Hiroaki Uchida, Yu Okubo, Tomoko Shibata, Yasuhiko Sasaki, Takuma Suzuki, Mika Hamada -Uematsu, Ryota Hamasaki, Kosaku Okuda, Miki Yamaguchi, Masaki Kojima, Masato Tanaka, Hirofumi Hamada, Hideaki Tahara
- Journal Title
  
  Journal of Virology
  
  Volume: 95 Issue: 9
- DOI
  10.1128/jvi.01766-20
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07319, KAKENHI-PROJECT-18H02687
[Journal Article] Immunoregulatory influence of abundant MFG-E8 expression by esophageal cancer treated with chemotherapy2018
- Author(s)
  Kanemura Takashi、Miyata Hiroshi、Makino Tomoki、Tanaka Koji、Sugimura Keijiro、Hamada-Uematsu Mika、Mizote Yu、Uchida Hiroaki、Miyazaki Yasuhiro、Takahashi Tsuyoshi、Kurokawa Yukinori、Yamasaki Makoto、Wada Hisashi、Nakajima Kiyokazu、Takiguchi Shuji、Mori Masaki、Doki Yuichiro、Tahara Hideaki
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 11 Pages: 3393-3402
- DOI
  10.1111/cas.13785
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07319, KAKENHI-PROJECT-17H01578
[Journal Article] Oncolytic Herpes Simplex Virus Vectors Fully Retargeted to Tumor- Associated Antigens2018
- Author(s)
  Uchida Hiroaki、Hamada Hirofumi、Nakano Kenji、Kwon Heechung、Tahara Hideaki、Cohen Justus B.、Glorioso Joseph C.
- Journal Title
  
  Current Cancer Drug Targets
  
  Volume: 18 Issue: 2 Pages: 162-170
- DOI
  10.2174/1568009617666170206105855
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08249
[Journal Article] Deletion of the Virion Host Shut-off Gene Enhances Neuronal-Selective Transgene Expression from an HSV Vector Lacking Functional IE Genes2017
- Author(s)
  Miyagawa Yoshitaka、Verlengia Gianluca、Reinhart Bonnie、Han Fang、Uchida Hiroaki、Zucchini Silvia、Goins William F.、Simonato Michele、Cohen Justus B.、Glorioso Joseph C.
- Journal Title
  
  Molecular Therapy - Methods & Clinical Development
  
  Volume: 6 Pages: 79-90
- DOI
  10.1016/j.omtm.2017.06.001
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08249
[Journal Article] Antiglycopeptide Mouse Monoclonal Antibody LpMab-21 Exerts Antitumor Activity Against Human Podoplanin Through Antibody-Dependent Cellular Cytotoxicity and Complement-Dependent Cytotoxicity.2017
- Author(s)
  Kato Y, Kunita A, Fukayama M, Abe S, Nishioka Y, Uchida H, Tahara H, Yamada S,Yanaka M, Nakamura T, Saidoh N, Yoshida K, Fujii Y, Honma R, Takagi M, Ogasawara S, Murata T, Kaneko MK.
- Journal Title
  
  Monoclon Antib Immunodiagn Immunother.
  
  Volume: 36(1) Issue: 1 Pages: 20-24
- DOI
  10.1089/mab.2016.0045
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26440019, KAKENHI-PROJECT-17H01578, KAKENHI-PROJECT-16H05309, KAKENHI-PROJECT-15K10459
[Journal Article] Angiotensin-converting enzyme 2 is a potential therapeutic target for EGFR-mutant lung adenocarcinoma.2017
- Author(s)
  Yamaguchi M, Hirai S, Sumi T, Tanaka Y, Tada M, Nishii Y, Hasegawa T, Uchida H, Yamada G, Watanabe A, Takahashi H, Sakuma Y.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 487(3) Issue: 3 Pages: 613-618
- DOI
  10.1016/j.bbrc.2017.04.102
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06876, KAKENHI-PROJECT-15K08364
[Journal Article] Chimeric Anti-Human Podoplanin Antibody NZ-12 of Lambda Light Chain Exerts Higher Antibody-Dependent Cellular Cytotoxicity and Complement-Dependent Cytotoxicity Compared with NZ-8 of Kappa Light Chain.2017
- Author(s)
  Kaneko MK, Abe S, Ogasawara S, Fujii Y, Yamada S, Murata T, Uchida H, Tahara H, Nishioka Y, Kato Y.
- Journal Title
  
  Monoclon Antib Immunodiagn Immunother.
  
  Volume: 36(1) Issue: 1 Pages: 25-29
- DOI
  10.1089/mab.2016.0047
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26440019, KAKENHI-PROJECT-17H01578, KAKENHI-PROJECT-16H05309
[Journal Article] Development of an oncolytic HSV vector fully retargeted specifically to cellular EpCAM for virus entry and cell-to-cell spread.2016
- Author(s)
  Shibata T, Uchida H, Shiroyama T, Okubo Y, Suzuki T, Ikeda H, Yamaguchi M, Miyagawa Y, Fukuhara T, Cohen JB, Glorioso JC, Watabe T, Hamada H, Tahara H.
- Journal Title
  
  Gene Therapy.
  
  Volume: 印刷中 Issue: 6 Pages: 479-488
- DOI
  10.1038/gt.2016.17
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15144, KAKENHI-PROJECT-25290059, KAKENHI-PROJECT-15K06876, KAKENHI-PROJECT-16K08249, KAKENHI-PROJECT-16K07184
[Journal Article] Syncytial Mutations Do Not Impair the Specificity of Entry and Spread of a Glycoprotein D Receptor-Retargeted Herpes Simplex Virus.2016
- Author(s)
  Okubo Y, Uchida H, Wakata A, Suzuki T, Shibata T, Ikeda H, Yamaguchi M, Cohen JB, Glorioso JC, Tagaya M, Hamada H, Tahara H.
- Journal Title
  
  J Virol.
  
  Volume: Nov28;90(24) Issue: 24 Pages: 11096-11105
- DOI
  10.1128/jvi.01456-16
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06876, KAKENHI-PROJECT-16K08249
[Journal Article] 大腸癌の遺伝子治療・ウイルス療法2015
- Author(s)
  内田宏昭, 田原秀晃
- Journal Title
  
  日本臨床
  
  Volume: 1077 Pages: 569-573
- Data Source
  KAKENHI-PROJECT-25290059
[Journal Article] Use of miRNA response sequences to block off-target replication and increase the safety of an unattenuated, glioblastoma-targeted oncolytic HSV.2015
- Author(s)
  Mazzacurati L, Marzulli M, Reinhart B, Miyagawa Y, Uchida H, Goins WF, Li A, Kaur B, Caligiuri M, Cripe T, Chiocca N, Amankulor N, Cohen JB, Glorioso JC, Grandi P.
- Journal Title
  
  Molecular Therapy.
  
  Volume: 23 Issue: 1 Pages: 99-107
- DOI
  10.1038/mt.2014.177
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25290059
[Journal Article] Herpes simplex viral-vector design for efficient transduction of nonneuronal cells without cytotoxicity.2015
- Author(s)
  Miyagawa Y, Marino P, Verlengia G, Uchida H, Goins WF, Yokota S, Geller DA, Yoshida O, Mester J, Cohen JB, Glorioso JC.
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America.
  
  Volume: 112 Issue: 13
- DOI
  10.1073/pnas.1423556112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25290059
[Journal Article] A newly developed anti-Mucin 13 monoclonal antibody targets pancreatic ductal adenocarcinoma cells.2015
- Author(s)
  Nishii Y, Yamaguchi M, Kimura Y, Hasegawa T, Aburatani H, Uchida H, Hirata K, Sakuma Y.
- Journal Title
  
  International Journal of Oncology.
  
  Volume: 46 Issue: 4 Pages: 1781-1787
- DOI
  10.3892/ijo.2015.2880
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K15144, KAKENHI-PROJECT-25290059
[Journal Article] 大腸癌の遺伝子治療・ウイルス療法2015
- Author(s)
  内田宏昭, 田原秀晃
- Journal Title
  
  日本臨床
  
  Volume: 1077 Pages: 569-573
- Data Source
  KAKENHI-PROJECT-15K15144
[Journal Article] Development of a sensitive screening method for selecting monoclonal antibodies to be internalized by cells.2014
- Author(s)
  Yamaguchi M, Nishii Y, Nakamura K, Aoki H, Hirai S, Uchida H, Sakuma Y, Hamada H.
- Journal Title
  
  Biochemical and Biophysical Research Communications.
  
  Volume: 454 Issue: 4 Pages: 600-603
- DOI
  10.1016/j.bbrc.2014.10.133
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25290059, KAKENHI-PROJECT-26462831
[Journal Article] Development of a novel efficient method to construct an adenovirus library displaying random peptides on the fiber knob.2014
- Author(s)
  Yamamoto Y, Goto N, Miura K, Narumi K, Ohnami S, Uchida H, Miura Y, Yamamoto M, Aoki K.
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25290059
[Journal Article] A targeting ligand enhances infectivity and cytotoxicity of an oncolytic adenovirus in human pancreatic cancer tissues.2014
- Author(s)
  Yamamoto Y, Hiraoka N, Goto N, Rin Y, Miura K, Narumi K, Uchida H, Tagawa M, Aoki K.
- Journal Title
  
  Journal of Control Release.
  
  Volume: 192 Pages: 284-293
- DOI
  10.1016/j.jconrel.2014.07.053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25290059
[Journal Article] Expression of HSV-1 receptors in EBV-associated lymphoproliferative disease determines susceptibility to oncolytic HSV2013
- Author(s)
  Wang PY, Currier MA, Hansford L, Kaplan D, Chiocca EA, Uchida H, Goins WF, Cohen JB, Glorioso JC, van Kuppevelt TH, Mo X, Cripe TP
- Journal Title
  
  Gene Ther
  
  Volume: 20(7) Pages: 761-769
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501309
[Journal Article] Expression of HSV-1 receptors in EBV-associated lymphoproliferative disease determines susceptibility to oncolytic HSV.2013
- Author(s)
  Wang PY, Currier MA, Hansford L, Kaplan D, Chiocca EA, Uchida H, Goins WF, Cohen JB, Glorioso JC, Kuppevelt TH, Mo X, Cripe TP.
- Journal Title
  
  Gene Therapy
  
  Volume: 20 Issue: 7 Pages: 761-769
- DOI
  10.1038/gt.2012.93
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25290059
[Journal Article] Novel mutations in gB and gH circumvent the requirement for known gD receptors in HSV-1 entry and cell-to-cell spread2013
- Author(s)
  Uchida H, Chan J, Shrivastava I, Reinhart B, Grandi P, Glorioso JC, Cohen JB
- Journal Title
  
  J Virol
  
  Volume: 87(3) Pages: 1430-42
- Data Source
  KAKENHI-PROJECT-23800058
[Journal Article] Effective treatment of an orthotopic xenograft model of human glioblastoma using an EGFR-retargeted oncolytic herpes simplex virus.2013
- Author(s)
  Uchida H, Marzulli M, Nakano K, Goins WF, Chan J, Hong CS, Mazzacurati L, Yoo JY, Haseley A, Nakashima H, Baek H, Kwon H, Kumagai I, Kuroki M, Kaur B, Chiocca EA, Grandi P, Cohen JB, Glorioso JC.
- Journal Title
  
  Molecular Therapy
  
  Volume: 21 Issue: 3 Pages: 561-569
- DOI
  10.1038/mt.2012.211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25290059
[Journal Article] Effective treatment of an orthotopic xenograft model of human glioblastoma using an EGFR-retargeted oncolytic herpes simplex virus2013
- Author(s)
  Uchida H, Marzulli M, Nakano K, Goins WF, Chan J, Hong CH, Mazzacurati L, Yoo JY, Haseley A, Nakashima H, Baek H, Kwon H, Kumagai I, Kuroki M, Kaur B, Chiocca EA, Grandi P, Cohen JB, Glorioso JC
- Journal Title
  
  Mol Ther
  
  Volume: 21(3) Pages: 561-9
- Data Source
  KAKENHI-PROJECT-23800058
[Journal Article] Novel mutations in gB and gH circumvent the requirement for known gD receptors in HSV-1 entry and cell-to-cell spread2013
- Author(s)
  Uchida H, Chan J, Shrivastava I, Reinhart B, Grandi P, Glorioso JC, Cohen JB
- Journal Title
  
  J Virol
  
  Volume: 87(3) Pages: 1430-1442
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501309
[Journal Article] Effective treatment of an orthotopic xenograft model of human glioblastoma using an EGFR-retargeted oncolytic herpes simplex virus2013
- Author(s)
  Uchida H, Marzulli M, Nakano K, Goins WF, Chan J, Hong CH, Mazzacurati L, Yoo JY, Haseley A, Nakashima H, Baek H, Kwon H, Kumagai I, Kuroki M, Kaur B, Chiocca EA, Grandi P, Cohen JB, Glorioso JC
- Journal Title
  
  Mol Ther
  
  Volume: 21(3) Pages: 561-569
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501309
[Journal Article] Novel mutations in gB and gH circumvent the requirement for known gD receptors in HSV-1 entry and cell-to-cell spread.2013
- Author(s)
  Uchida H, Chan J, Shrivastava I, Reinhart B, Grandi P, Glorioso JC, Cohen JB.
- Journal Title
  
  Journal of Virology
  
  Volume: 87 Issue: 3 Pages: 1430-1442
- DOI
  10.1128/jvi.02804-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25290059
[Journal Article] Bispecific adapter-mediated retargeting of a receptor-restricted HSV-1 vector to CEA-bearing tumor cells2011
- Author(s)
  Baek H, Uchida H, Jun K, Kim JH, Kuroki M, Cohen JB, Glorioso JC, Kwon H
- Journal Title
  
  Mol Ther
  
  Volume: 19(3) Issue: 3 Pages: 507-14
- DOI
  10.1038/mt.2010.207
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23800058
[Journal Article] Expression of HSV-1 receptors in EBV-associated lymphoproliferative disease determines susceptibility to oncolytic HSV
- Author(s)
  Wang PY, Currier MA, Hansford L, Kaplan D, Chiocca EA, Uchida H, Goins WF, Cohen JB, Glorioso JC, Kuppevelt TH, Mo X, Cripe TP
- Journal Title
  
  Gene Ther
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-23800058
[Patent] ONCOLYTIC HSV VECTOR (divisional)2021
- Inventor(s)
  Hiroaki Uchidaら
- Industrial Property Rights Holder
  Hiroaki Uchidaら
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-18H02687
[Patent] ONCOLYTIC HSV VECTOR (continuation)2020
- Inventor(s)
  Hiroaki Uchidaら
- Industrial Property Rights Holder
  Hiroaki Uchidaら
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-18H02687
[Patent] ONCOLYTIC HSV VECTOR (divisional)2020
- Inventor(s)
  Hiroaki Uchidaら
- Industrial Property Rights Holder
  Hiroaki Uchidaら
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-18H02687
[Patent] がん治療のための腫瘍溶解性ウイルス2019
- Inventor(s)
  内田宏昭・田原秀晃
- Industrial Property Rights Holder
  内田宏昭・田原秀晃
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-18H02687
[Patent] がん治療のための腫瘍溶解性ウイルス2019
- Inventor(s)
  内田宏昭・田原秀晃
- Industrial Property Rights Holder
  内田宏昭・田原秀晃
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-18K19468
[Presentation] 高性能イミュノトキシンを用いた小細胞肺がんに対する標的の探索2021
- Author(s)
  山口美樹、藤谷直樹、平井幸恵、高橋素子、内田宏昭、佐久間裕司
- Organizer
  第123回北海道癌談話会例会
- Data Source
  KAKENHI-PROJECT-21K08161
[Presentation] 新規ウイルス産生細胞を用いた無毒化ヘルペスウイルスベクターの生産系の確立.2017
- Author(s)
  黒田誠司、宮川世志幸、足立久美、山本基子、Cohen Justus B.、Glorioso Joseph C.、鈴木英之、内田英二、岡田尚巳.
- Organizer
  2017年度生命科学系学会合同年次大会(ConBio2017)
- Data Source
  KAKENHI-PROJECT-16K08249
[Presentation] がん細胞のみに侵入可能な標的化改変ヘルペスウイルスの開発2016
- Author(s)
  内田宏昭
- Organizer
  第116回日本外科学会定期学術集会
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-15K15144
[Presentation] がん細胞のみに侵入可能な標的化改変ヘルペスウイルスの開発2016
- Author(s)
  内田宏昭
- Organizer
  第116回日本外科学会定期学術集会
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-25290059
[Presentation] がん細胞表面抗原を介して細胞内侵入する標的化改変単純ヘルペスウイルスベクターの開発2015
- Author(s)
  内田宏昭
- Organizer
  第56回日本臨床ウイルス学会
- Place of Presentation
  岡山大学鹿田キャンパス（岡山県岡山市）
- Year and Date
  2015-06-13
- Invited
- Data Source
  KAKENHI-PROJECT-15K15144
[Presentation] Exploration of cancer-targeting antibodies using an HSV-based screening system for development of novel HSV vectors fully retargeted to cancer cells.2015
- Author(s)
  内田宏昭
- Organizer
  The 21th Annual Meeting of Japan Society of Gene Therapy.
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2015-07-24
- Data Source
  KAKENHI-PROJECT-25290059
[Presentation] 腫瘍細胞表面抗原を介して侵入する標的化単純ヘルペスウイルスベクターの開発2015
- Author(s)
  城山智貴, 内田宏昭, 大久保優, 柴田智子, 福原武志, 山口美樹, Justus B. Cohen, Joseph C. Glorioso, 渡部徹郎, 濱田洋文, 田原秀晃
- Organizer
  第7回血液疾患免疫療法研究会
- Place of Presentation
  東京大学本郷キャンパス（東京都文京区）
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-15K15144
[Presentation] Exploration of cancer-targeting antibodies using an HSV-based screening system for development of novel HSV vectors fully retargeted to cancer cells.2015
- Author(s)
  内田宏昭
- Organizer
  The 21th Annual Meeting of Japan Society of Gene Therapy.
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2015-07-24
- Data Source
  KAKENHI-PROJECT-15K15144
[Presentation] 腫瘍細胞表面抗原を介して侵入する標的化単純ヘルペスウイルスベクターの開発2015
- Author(s)
  城山智貴, 内田宏昭, 大久保優, 柴田智子, 福原武志, 山口美樹, Justus B. Cohen, Joseph C. Glorioso, 渡部徹郎, 濱田洋文, 田原秀晃
- Organizer
  第7回血液疾患免疫療法研究会
- Place of Presentation
  東京大学本郷キャンパス（東京都文京区）
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-25290059
[Presentation] がん細胞表面抗原を介して細胞内侵入する標的化改変単純ヘルペスウイルスベクターの開発2015
- Author(s)
  内田宏昭
- Organizer
  第56回日本臨床ウイルス学会
- Place of Presentation
  岡山大学鹿田キャンパス（岡山県岡山市）
- Year and Date
  2015-06-13
- Invited
- Data Source
  KAKENHI-PROJECT-25290059
[Presentation] Application of in-house monoclonal antibody resources to a fully retargeted oncolytic herpes simplex virus platform2013
- Author(s)
  Yu Okubo1, Takuma Suzuki1, Tomoko Shibata1, Mao Komai1, Takeshi Fukuhara1, Miki Yamaguchi2, Sachie Hirai2, Yoshitaka Miyagawa3, Justus B. Cohen3, Joseph C. Glorioso3, Hirofumi Hamada1, and Hiroaki Uchida1
- Organizer
  第７２回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23501309
[Presentation] Syncytial mutations augment the oncolytic potential of a fully retargeted herpes simplex virus vector.2013
- Author(s)
  Wakata A, Okubo Y, Fukuhara T, Cohen JB, Joseph C. Glorioso JC, Nakano K, Kumagai I, Kuroki M, Hamada H, Uchida H.
- Organizer
  The 19th Annual Meeting of Japan Society of Gene Therapy.
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-25290059
[Presentation] Establishment of highly functional monoclonal antibodies through novel screening methods for targeted cancer therapy2013
- Author(s)
  Moegi Sato1, Miki Yamaguchi2, Hitomi Ikeda1, Yuta Matsuura1, Takeshi Fukuhara1, Hirofumi Hamada1, and Hiroaki Uchida1
- Organizer
  第81回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23501309
[Presentation] 白血病/リンパ腫に対するスーパー標的化抗体を用いたイムノトキシンの開発2013
- Author(s)
  西井ゆかり、山口美樹、平井幸恵、内田宏昭、濱田洋
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2013-10-03
- Data Source
  KAKENHI-PROJECT-23501309
[Presentation] エンベロープ糖タンパクgDにがん標的化単鎖抗体を挿入した単純ヘルペスウイルスを用いた腫瘍溶解ウイルス療法の開発2013
- Author(s)
  鈴木拓真, 柴田智子, 大久保優, 福原武志, 宮川世志幸, Justus Cohen, Joseph Glorioso, 中野賢二, 熊谷泉, 黒木政秀, 山口美樹, 平井幸恵, 濱田洋文, 内田宏昭
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25290059
[Presentation] 単純ヘルペスウイルスの標的化改変プラットフォームへのがん標的化抗体インハウスリソースの適用2013
- Author(s)
  柴田智子, 鈴木拓真, 大久保優, 駒井麻央, 福原武志, 山口美樹, 平井幸恵, 宮川世志幸, Justus Cohen, Joseph Glorioso, 濱田洋文, 内田宏昭
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25290059
[Presentation] Application of monoclonal antibody resources to a fully retargeted HSV platform2013
- Author(s)
  Tomoko Shibata1, Takuma Suzuki1, Yu Okubo1, Mao Komai1, Takeshi Fukuhara1, Miki Yamaguchi2, Sachie Hirai2, Yoshitaka Miyagawa3, Justus B. Cohen3, Joseph C. Glorioso3, Hirofumi Hamada1, and Hiroaki Uchida1
- Organizer
  第６１回日本ウイルス学会学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23501309
[Presentation] Manipulation of multiple herpes simplex virus glycoproteins for fully retargeted entry and efficient cell-to-cell spread.2013
- Author(s)
  Wakata A, Okubo Y, Fukuhara T, Cohen JB, Glorioso JC, Nakano K, Kumagai I, Kuroki M, Hamada H, Uchida H.
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25290059
[Presentation] Development of fully retargeted oncolytic herpes simplex virus vectors by insertion of tumor-specific single-chain antibodies into viral envelope glycoprotein D2013
- Author(s)
  Takuma Suzuki1, Tomoko Shibata1, Yu Okubo1, Takeshi Fukuhara1, Yoshitaka Miyagawa2, Justus B. Cohen2, Joseph C. Glorioso2, Kenji Nakano3, Izumi Kumagai4, Masahide Kuroki5, Miki Yamaguchi6, Sachie Hirai6, Hirofumi Hamada1, and Hiroaki Uchida1
- Organizer
  第６１回日本ウイルス学会学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23501309
[Presentation] Generation of immunotoxins with super-targeting mAb in the leukemia/lymphoma2013
- Author(s)
  Yukari Nishii1, Miki Yamaguchi1, Hiroaki Uchida2, Hirofumi Hamada1,2
- Organizer
  第７２回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23501309
[Presentation] Application of in-house monoclonal antibody resources to a fully retargeted oncolytic herpes simplex virus platform.2013
- Author(s)
  Okubo Y, Suzuki T, Shibata T, Komai M, Fukuhara T, Yamaguchi M, Hirai S, Miyagawa Y, Cohen JB, Glorioso JC, Hamada H, Uchida H.
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25290059
[Presentation] 高性能癌標的化抗体の網羅的探索と標的化ヘルペスウイルスベクター系の完成2012
- Author(s)
  内田宏昭
- Organizer
  バイオテック2012アカデミックフォーラム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23800058
[Presentation] 標的化ヘルペスウイルスでがんを狙い撃ち-エンベロープ糖タンパクの遺伝子工学的改変2012
- Author(s)
  内田宏昭、濱田洋文、Justus B. Cohen、Joseph C. Glorioso
- Organizer
  第2回医薬工3大学包括連携推進シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23800058
[Presentation] Fully retargeted herpes simplex virus vector by co-engineering of viral glycoproteins2011
- Author(s)
  Uchida H
- Organizer
  The 17th Annual Meeting of the Japan Society of Gene Therapy
- Place of Presentation
  Fukuoka, Japan
- Data Source
  KAKENHI-PROJECT-23800058
[Presentation] Fully retargeted herpes simplex virus vector by co-engineering of viral glycoproteins2011
- Author(s)
  Uchida, H
- Organizer
  The 17th Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  Hakata, Japan
- Data Source
  KAKENHI-PROJECT-23800058
[Presentation] 単純ヘルペスウイルスのターゲティング-2種類のウイルス糖タンパクの同時改変2011
- Author(s)
  内田宏昭, 中野賢二, Chang-Sook Hong, William Goins, Janet Chan, Heechung Kwon, 熊谷泉, 黒木政秀, Justus Cohen, Joseph Glorioso
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23800058
[Presentation] 腫瘍細胞のみに感染可能な標的化ヘルペスウイルスベクターの実現2011
- Author(s)
  内田宏昭, Justus Cohen, Joseph Glorioso
- Organizer
  第111回日本外科学会定期学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23800058
[Presentation] 腫瘍細胞のみに感染可能な標的化ヘルペスウイルスベクターの実現2011
- Author(s)
  内田宏昭, Justus Cohen, Joseph Glorioso
- Organizer
  第111回日本外科学会定期学術集会
- Place of Presentation
  東京(紙上開催)
- Data Source
  KAKENHI-PROJECT-23800058
[Presentation] Exploration of cancer-targeting antibodies using an HSV-based screening system.
- Author(s)
  Okubo Y, Ikeda H, Fukuhara T, Kojima M, Cohen JB, Glorioso JC, Hamada H, Watabe T, Uchida H.
- Organizer
  The 39th International Herpesvirus Workshop.
- Place of Presentation
  神戸コンベンションセンター（兵庫県神戸市）
- Year and Date
  2014-07-19 – 2014-07-23
- Data Source
  KAKENHI-PROJECT-25290059
[Presentation] Development of a new generation of herpes simplex virus vectors fully retargeted to a variety of tumor-associated antigens.
- Author(s)
  Uchida H, Okubo Y, Shibata T, Suzuki T, Ikeda H, Shiroyama T, Fukuhara T, Kojima M, Yamaguchi M, Miyagawa Y, Cohen JB, Glorioso JC, Hamada H.
- Organizer
  The 20th Annual Meeting of Japan Society of Gene Therapy.
- Place of Presentation
  東京慈恵会医科大学（東京都港区）
- Year and Date
  2014-08-06 – 2014-08-08
- Data Source
  KAKENHI-PROJECT-25290059
[Presentation] Augmentation of oncolytic potential of a fully retargeted HSV vector by introduction of syncytial mutations.
- Author(s)
  Wakata A, Okubo Y, Fukuhara T, Cohen JB, Glorioso JC, Nakano K, Kumagai I, Kuroki M, Hamada H, Watabe T, Uchida H.
- Organizer
  The 39th International Herpesvirus Workshop.
- Place of Presentation
  神戸コンベンションセンター（兵庫県神戸市）
- Year and Date
  2014-07-19 – 2014-07-23
- Data Source
  KAKENHI-PROJECT-25290059
[Presentation] Generation of an EpCAM-retargeted HSV vector by application of in-house monoclonal antibody resources.
- Author(s)
  Shibata T, Shiroyama T, Suzuki T, Okubo Y, Fukuhara T, Yamaguchi M, Miyagawa Y, Cohen JB, Glorioso JC, Hamada H, Watabe T, Uchida H.
- Organizer
  The 39th International Herpesvirus Workshop.
- Place of Presentation
  神戸コンベンションセンター（兵庫県神戸市）
- Year and Date
  2014-07-19 – 2014-07-23
- Data Source
  KAKENHI-PROJECT-25290059

1. TAHARA HIDEAKI (70322071)

# of Collaborated Projects: 8 results

# of Collaborated Products: 8 results
2. YAMAGUCHI MIKI (10530454)

# of Collaborated Projects: 6 results

# of Collaborated Products: 16 results
3. Mika Hamada-Uematsu (90769449)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
4. 佐久間裕司 (10364514)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
5. 高橋素子 (00303941)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. 藤谷直樹 (10374191)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. HAMADA Hirofumi (00189614)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
8. HIRAI Sachie (20218754)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. FUKUHARA TAKESHI (20359673)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
10. KASUYA Hideki (00402636)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KODERA Yasuhiro (10345879)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. YAMADA Suguru (30467287)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SHIKU Hiroshi (80154194)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. NOMOTO Shuji (40300967)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KOJIMA MASAKI (90277252)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. Yoshitaka Miyagawa (90415604)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. 西井ゆかり (10619505)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. 土岐祐一郎 (20291445)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 田中晃司 (70621019)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 角俊行 (60772291)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 田中悠祐 (70792125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 多田周 (00815441)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. Glorioso Joseph C., III

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
24. KUNITA Akiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 金子美華

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Uchida Hiroaki 内田 宏昭

UCHIDA Hiroaki 内田 宏昭

Research Projects

Research Products

Co-Researchers

膜融合能増強型標的化ヘルペスウイルスのさらなる改変による抗腫瘍免疫誘導能の増強Principal Investigator

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Treatment of metastatic tumors by systemic injection of tumor-retargeted oncolytic herpesvirusesPrincipal Investigator

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Development of oncolytic herpes simplex virus vectors retargeted to hematological malignanciesPrincipal Investigator

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Development of highly specific oncolytic herpes virus vectors by modification of two envelope glycoproteinsPrincipal Investigator

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Augmentation of tumor specificity and killing activity of oncolytic herpes virus vectorsPrincipal Investigator

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Uchida Hiroaki 内田宏昭

UCHIDA Hiroaki 内田宏昭