Isotani Ayako 磯谷綾子

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ISOTANI Ayako 磯谷綾子

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Researcher Number	20444523
Other IDs
Affiliation (Current)	2025: 奈良先端科学技術大学院大学, 先端科学技術研究科, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2024: 奈良先端科学技術大学院大学, 先端科学技術研究科, 准教授 2017: 大阪大学, 免疫学フロンティア研究センター, 特任准教授 2017: 奈良先端科学技術大学院大学, 器官発生工学, 准教授 2016 – 2017: 奈良先端科学技術大学院大学, バイオサイエンス研究科, 准教授 2016: 奈良先端科学技術大学院大学, 准教授 … More 2013 – 2015: 大阪大学, 免疫学フロンティア研究センター, 特任准教授 2013 – 2014: 大阪大学, 免疫学フロンティア研究センター, 特任准教授(常勤) 2012: 大阪大学, 微生物病研究所, 特任准教授 2007 – 2011: Osaka University, 微生物病研究所, 助教 Less
Review Section/Research Field	Principal Investigator Laboratory animal science / Laboratory animal science / Biological Sciences / Medium-sized Section 90:Biomedical engineering and related fields / Basic Section 42040:Laboratory animal science-related / Medium-sized Section 44:Biology at cellular to organismal levels, and related fields / Biological Sciences Except Principal Investigator Basic Section 44020:Developmental biology-related / Medium-sized Section 44:Biology at cellular to organismal levels, and related fields / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields … More / Functional biochemistry / Biological Sciences / Laboratory animal science / Laboratory animal science / Biological Sciences Less
Keywords	Principal Investigator 胎盤 / 生殖細胞 / 胚盤胞補完法 / 臓器移植 / 再生医療 / 異種間キメラ / 発生工学 / 異種 / 実験動物 / 疾患モデル動物 … More / 脱細胞 / 子宮 / 胚体外細胞 / 異種間 / ハイブリッド / 脱落膜 / 母子間認識 / ES細胞 / キメラ動物 / ラット / キメラ / 性分化 / 動物モデル / 不妊治療 / 妊娠 / モデル動物 / 遺伝子組み換え / 異種キメラ / 遺伝子組換え / Y染色体 / 精子幹細胞 / iPS細胞 / 疾患モデル / 不妊 / GFP / 雌雄キメラ / 性転換マウス / 細胞増殖制御 / 雄性生殖細胞 / 遺伝子操作マウス / 性染色体 / トランスポゾン … More Except Principal Investigator ゲノム編集 / マウス / 不妊 / 遺伝子組換え / 人工制限酵素 / ノックアウト / 実験動物 / CRISPR/Cas / CRISPR/Cas9 / ノックイン / ES細胞 / 点変異 / 遺伝子破壊 / 生殖不全 / ラット / 異種キメラ / 受精 / 生殖細胞 / ノックアウトマウス / エピゲノム / マウス胚 / 細胞分化 / 細胞増殖 / ニワトリ胚 / 神経分化 / 幹細胞 / モルフォゲン / 中枢神経系 / オルガノイド / 神経損傷 / 胚性幹細胞 / 神経管 / BMPシグナル / 大脳腹側部 / Prominin-1 / コンピテンス / Phc1 / ソニック・ヘッジホッグ / 生殖細胞体外再構築 / 胚盤胞補完法 / アマミトゲネズミ / 生殖巣 / iPS細胞 / 絶滅危惧種 / 性決定 / 抗体 / IgA抗体 / IgA / クラススイッチ / アレルギー / CRISPR/CAS9 / 細胞外マトリックス / 生殖 / 精子形成 / 卵子 / 精子 / 胎盤 / 卵子機能 / 精子機能 / 男性避妊薬 / 受精能 / 着床 / 発生工学 / 自己・非自己 / マウス・ラットキメラ / 免疫 / 排卵 / 性転換マウス / ゲノム・インプリント / 分子シャペロン / 遺伝子組換え動物 / エピジェネティック / マイクロRNA Less

異種間キメラ動体内で多能性幹細胞由来の子宮を作る研究Principal Investigator
- Principal Investigator
  
  磯谷綾子
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Nara Institute of Science and Technology
胎児の臓器を立体構造を保持したまま成体内で育てる研究Principal Investigator
- Principal Investigator
  
  磯谷綾子
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Nara Institute of Science and Technology
Study of recognition mechanism between mother and embryo using the xeno-hybrid placentaPrincipal Investigator
- Principal Investigator
  
  Isotani Ayako
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
- Research Institution
  Nara Institute of Science and Technology
Elucidation of the gene expression cascade responsible for male sexuality and acquisition of fertility
- Principal Investigator
  
  本多新
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
- Research Institution
  Jichi Medical University
Positional and quantitative regulation of the central nervous cells by interaction of pattern formation, proliferation and differentiation timing
- Principal Investigator
  
  Sasai Noriaki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 44020:Developmental biology-related
- Research Institution
  Nara Institute of Science and Technology
A novel treatment of allergy by mucosal barrier enhancement through selective IgA class switching
- Principal Investigator
  
  Shinkura Reiko
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  The University of Tokyo
A study of the dominance of sex differentiation in the sex chimeric rat modelPrincipal Investigator
- Principal Investigator
  
  磯谷綾子
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Nara Institute of Science and Technology
Development of a new treatment model for placental dysfunctionPrincipal Investigator
- Principal Investigator
  
  ISOTANI Ayako
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Nara Institute of Science and Technology
A model of xenogeneic fetus pregnancy by the placenta replacement methodPrincipal Investigator
- Principal Investigator
  
  Isotani Ayako
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory animal science
- Research Institution
  Osaka University
Analysis of extracellular matrices that regulate mammalian reproduction
- Principal Investigator
  
  Kiyozumi Daiji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Osaka University
Application of CRISPR/Cas9 system for gene manipulation in mice
- Principal Investigator
  
  IKAWA MASAHITO
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Laboratory animal science
- Research Institution
  Osaka University
Functional analysis of fertilization related genes in mice
- Principal Investigator
  
  IKAWA MASAHITO
- Project Period (FY)
  2013 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Self and non-self in mouse-rat chimera
- Principal Investigator
  
  OKABE Masaru
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Laboratory animal science
- Research Institution
  Osaka University
Generation of knock out rat using mouse <-> rat chimeraPrincipal Investigator
- Principal Investigator
  
  ISOTANI Ayako
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Osaka University
Ｙ染色体の精子幹細胞維持に関わる遺伝子領域の同定Principal Investigator
- Principal Investigator
  
  磯谷綾子
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Development of infertility treatment model using infertile mice and iPS cellsPrincipal Investigator
- Principal Investigator
  
  ISOTANI Ayako
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Osaka University
雄性生殖細胞の分裂再開を制御する分子メカニズムの研究Principal Investigator
- Principal Investigator
  
  磯谷綾子
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Mechanism of mammalian fertilization and epigenomic regulation of germline cells.
- Principal Investigator
  
  OKABE Masaru
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Research of proliferation and differentiation in germline cells useing transposonPrincipal Investigator
- Principal Investigator
  
  ISOTANI Ayako
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Osaka University

[Book] 生命科学から創薬へのイノベーション2014
- Author(s)
  磯谷綾子、伊川正人
- Total Pages
  202
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-24500490
[Book] 生命科学から創薬へのイノベーション2014
- Author(s)
  磯谷綾子、伊川正人
- Total Pages
  202
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-24240066
[Book] 実験医学2014
- Author(s)
  磯谷綾子
- Total Pages
  132
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-24500490
[Book] プログレッシブ　生命科学2014
- Author(s)
  磯谷綾子、伊川正人
- Total Pages
  312
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-24500490
[Book] プログレッシブ　生命科学2014
- Author(s)
  磯谷綾子、伊川正人
- Total Pages
  312
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-24240066
[Book] 実験医学2014
- Author(s)
  磯谷綾子
- Total Pages
  132
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-24240066
[Book] 蛋白質核酸酵素「生殖細胞の発生・エピジェネティクスと再プログラム化」2007
- Author(s)
  磯谷綾子, 岡部勝
- Publisher
  共立出版
- Data Source
  KAKENHI-PROJECT-19700368
[Journal Article] Generating an organ-deficient animal model using a multi-targeted CRISPR-Cas9 system2024
- Author(s)
  Jonathan Jun-Yong Lim, Yamato Murata, Shunsuke Yuri, Kohei Kitamuro, Taro Kawai and Ayako Isotani
- Journal Title
  
  Scientific Reports
  
  Volume: 14 Issue: 1 Pages: 10636-10636
- DOI
  10.1038/s41598-024-61167-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18577
[Journal Article] Generation of rat-derived lung epithelial cells in Fgfr2b-deficient mice retains species-specific development2024
- Author(s)
  Yuri Shunsuke、Murase Yuki、Isotani Ayako
- Journal Title
  
  Development
  
  Volume: 151 Issue: 1
- DOI
  10.1242/dev.202081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K18577
[Journal Article] Acquisition of neural fate by combination of BMP blockade and chromatin modification2023
- Author(s)
  Ong Agnes Lee Chen、Kokaji Toshiya、Kishi Arisa、Takihara Yoshihiro、Shinozuka Takuma、Shimamoto Ren、Isotani Ayako、Shirai Manabu、Sasai Noriaki
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 10 Pages: 107887-107887
- DOI
  10.1016/j.isci.2023.107887
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16349, KAKENHI-PROJECT-20H03263
[Journal Article] Scheduled simple production method of pseudopregnant female mice for embryo transfer using the luteinizing hormone-releasing hormone agonist2022
- Author(s)
  Gema Puspa Sari, Patrick Louis Lagman Hilario, Shunsuke Yuri 1, Arata Honda, Ayako Isotani
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 21985-21985
- DOI
  10.1038/s41598-022-26425-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18367, KAKENHI-PROJECT-20H00469, KAKENHI-PROJECT-21K19267
[Journal Article] TESMIN, METALLOTHIONEIN-LIKE 5, is required for spermatogenesis in mice.2020
- Author(s)
  Oji A, Isotani A, Fujihara Y, Castaneda JM, Oura S, Ikawa M.
- Journal Title
  
  Biology of Reproduction
  
  Volume: 102 Issue: 4 Pages: 975-983
- DOI
  10.1093/biolre/ioaa002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-18H04885, KAKENHI-ORGANIZER-19H05749, KAKENHI-PROJECT-18K14715, KAKENHI-PROJECT-20K15804, KAKENHI-PROJECT-17H01394
[Journal Article] Developmental analyses of mouse embryos and adults using a non-overlapping tracing system for all three germ layers2019
- Author(s)
  Serizawa Takashi、Isotani Ayako、Matsumura Takafumi、Nakanishi Katsuyuki、Nonaka Shigenori、Shibata Shinsuke、Ikawa Masahito、Okano Hideyuki
- Journal Title
  
  Development
  
  Volume: 146 Pages: 1-11
- DOI
  10.1242/dev.174938
- NAID
  120006957441
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07425, KAKENHI-PROJECT-18K14840, KAKENHI-PUBLICLY-18H04885, KAKENHI-ORGANIZER-19H05749, KAKENHI-PROJECT-16H06280
[Journal Article] Male mice, caged in the International space station for 35 days, sire healthy offspring.2019
- Author(s)
  Matsumura T, Noda T, Muratani M, Okada R, Yamane M, Isotani A, Kudo T, Takahashi S, Ikawa M.
- Journal Title
  
  Scientific Research
  
  Volume: 9 Issue: 1 Pages: 13733-13733
- DOI
  10.1038/s41598-019-50128-w
- NAID
  120006957452
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-18H04885, KAKENHI-PUBLICLY-18H04965, KAKENHI-ORGANIZER-19H05749, KAKENHI-PLANNED-19H05750, KAKENHI-PROJECT-17H01394, KAKENHI-PROJECT-18K14612, KAKENHI-ORGANIZER-15H05935
[Journal Article] An azoospermic factor gene, <i>Ddx3y</i> and its paralog, <i>Ddx3x</i> are dispensable in germ cells for male fertility2019
- Author(s)
  MATSUMURA Takafumi、ENDO Tsutomu、ISOTANI Ayako、OGAWA Masaki、IKAWA Masahito
- Journal Title
  
  J. Reprod. Dev.
  
  Volume: 65 Issue: 2 Pages: 121-128
- DOI
  10.1262/jrd.2018-145
- NAID
  130007630965
- ISSN
  0916-8818, 1348-4400
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17J09669, KAKENHI-PROJECT-19K06439, KAKENHI-PUBLICLY-18H04885
[Journal Article] Chimeric analysis with newly established EGFP/DsRed2-tagged ES cells identify HYDIN as essential for spermiogenesis in mice2019
- Author(s)
  Oura Seiya、Miyata Haruhiko、Noda Taichi、Shimada Keisuke、Matsumura Takafumi、Morohoshi Akane、Isotani Ayako、Ikawa Masahito
- Journal Title
  
  Exp. Anim.
  
  Volume: 68 Issue: 1 Pages: 25-34
- DOI
  10.1538/expanim.18-0071
- NAID
  130007604401
- ISSN
  0007-5124, 1341-1357, 1881-7122
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14612, KAKENHI-PROJECT-17H01394, KAKENHI-PROJECT-17H04987, KAKENHI-PROJECT-17J09669, KAKENHI-PROJECT-17K17852, KAKENHI-PUBLICLY-18H04885, KAKENHI-PROJECT-16K07091
[Journal Article] CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice†2019
- Author(s)
  Yonggang Lu, Oura Seiya, Matsumura Takafumi, et al.
- Journal Title
  
  Biology of Reproduction
  
  Volume: 101 Issue: 2 Pages: 501-511
- DOI
  10.1093/biolre/ioz103
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16735, KAKENHI-PUBLICLY-18H04885, KAKENHI-ORGANIZER-19H05749, KAKENHI-PROJECT-17H01394, KAKENHI-PROJECT-17H04987, KAKENHI-PROJECT-19J00865, KAKENHI-PROJECT-17K17852, KAKENHI-PROJECT-18K14612, KAKENHI-PROJECT-18K14715, KAKENHI-PROJECT-16KK0180
[Journal Article] Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis2017
- Author(s)
  Ueda J., Harada A., Urahama T., Machida S., Maehara K., Hada M., Makino Y., Nogami J., Horikoshi N., Osakabe A., Taguchi H., Tanaka H., Tachiwana H., Yao T., Yamada M., Iwamoto T., Isotani A., Ikawa M., Tachibana T., Okada Y., Kimura H., Ohkawa Y., Kurumizaka H., Yamagata K.
- Journal Title
  
  Cell Reports
  
  Volume: 18(3) Issue: 3 Pages: 593-600
- DOI
  10.1016/j.celrep.2016.12.065
- NAID
  120006957416
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-15H05976, KAKENHI-PUBLICLY-16H01219, KAKENHI-PUBLICLY-16H01550, KAKENHI-PUBLICLY-16H01577, KAKENHI-PLANNED-25112007, KAKENHI-PLANNED-25116002, KAKENHI-PLANNED-25116005, KAKENHI-PLANNED-25116010, KAKENHI-PROJECT-25250014, KAKENHI-PROJECT-15J06922, KAKENHI-PROJECT-16J09361, KAKENHI-PROJECT-25712035, KAKENHI-PROJECT-15K18457, KAKENHI-PROJECT-16K08748, KAKENHI-PROJECT-16K18473, KAKENHI-PROJECT-16K18479, KAKENHI-ORGANIZER-25112001, KAKENHI-PROJECT-16K07099, KAKENHI-PUBLICLY-16H01319, KAKENHI-PROJECT-17J06605
[Journal Article] A delayed sperm penetration of cumulus layers by disruption of acrosin gene in rats.2017
- Author(s)
  Isotani A, Matsumura T, Ogawa M, Tanaka T, Yamagata K, Ikawa M, Okabe M.
- Journal Title
  
  Biology of Reproduction
  
  Volume: 97(1) Issue: 1 Pages: 61-68
- DOI
  10.1093/biolre/iox066
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-25112007, KAKENHI-PROJECT-16H06276
[Journal Article] Generation of Hprt-disrupted rat through mouse←rat ES chimeras.2016
- Author(s)
  Isotani A, Yamagata K, Okabe M, Ikawa M
- Journal Title
  
  Sci Rep
  
  Volume: 6 Issue: 1 Pages: 24215-24215
- DOI
  10.1038/srep24215
- NAID
  120006957423
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-25116005, KAKENHI-PROJECT-15K14367, KAKENHI-PLANNED-25112007, KAKENHI-PROJECT-25250014, KAKENHI-PROJECT-25712035, KAKENHI-PROJECT-16H06276, KAKENHI-ORGANIZER-25112001
[Journal Article] Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice.2016
- Author(s)
  Miyata H, Castaneda JM, Fujihara Y, Yu Z, Archambeault DR, Isotani A, Kiyozumi D, Kriseman ML, Mashiko D, Matsumura T, Matzuk RM, Mori M, Noda T, Oji A, Okabe M, Prunskaite-Hyyrylainen R, Ramirez-Solis R, Satouh Y, Zhang Q, Ikawa M, Matzuk MM.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 113 Issue: 28 Pages: 7704-7710
- DOI
  10.1073/pnas.1608458113
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-25112007, KAKENHI-PROJECT-25250014, KAKENHI-PROJECT-15H05573, KAKENHI-PROJECT-15J04519, KAKENHI-PROJECT-16K15687, KAKENHI-PROJECT-15K18387, KAKENHI-PROJECT-26830056, KAKENHI-PROJECT-15K06999, KAKENHI-PROJECT-16H06276, KAKENHI-ORGANIZER-25112001
[Journal Article] Behavior of Mouse Spermatozoa in the Female Reproductive Tract from Soon after Mating to the Beginning of Fertilization.2016
- Author(s)
  Muro Y, Hasuwa H, Isotani A, Miyata H, Yamagata K, Ikawa M, Yanagimachi R, Okabe M
- Journal Title
  
  Biol Reprod
  
  Volume: 印刷中 Issue: 4 Pages: 80-80
- DOI
  10.1095/biolreprod.115.135368
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-25116005, KAKENHI-PLANNED-25112007, KAKENHI-PROJECT-25250014, KAKENHI-PROJECT-25712035, KAKENHI-ORGANIZER-25112001
[Journal Article] CRISPR/Cas9 mediated genome editing in ES cells and its application for chimeric analysis in mice.2016
- Author(s)
  Oji A, Noda T, Fujihara Y, Miyata H, Kim YJ, Muto M, Nozawa K, Matsumura T, Isotani A, Ikawa M.
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Issue: 1 Pages: 34666-34666
- DOI
  10.1038/srep31666
- NAID
  120006957419
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-25112007, KAKENHI-PROJECT-25250014, KAKENHI-PROJECT-15H05573, KAKENHI-PROJECT-15J04519, KAKENHI-PROJECT-16J04613, KAKENHI-PROJECT-26830056, KAKENHI-ORGANIZER-25112001
[Journal Article] Calreticulin is required for development of the cumulus oocyte complex and female fertility.2015
- Author(s)
  Tokuhiro K, Satouh Y, Nozawa K, Isotani A, Fujihara Y, Hirashima Y, Matsumura H, Takumi K, Miyano T, Okabe M, Benham AM, Ikawa M.
- Journal Title
  
  Sci Rep.
  
  Volume: 5 Issue: 1 Pages: 14254-14254
- DOI
  10.1038/srep14254
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-INTERNATIONAL-15K21737, KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-25112007, KAKENHI-PROJECT-25250014, KAKENHI-PROJECT-15H05573, KAKENHI-PROJECT-15K14366, KAKENHI-PROJECT-26860258, KAKENHI-PROJECT-26292136
[Journal Article] Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive2015
- Author(s)
  Haruhiko Miyata, Yuhkoh Satouh, Daisuke Mashiko, Masanaga Muto, Kaori Nozawa, Kogiku Shiba, Yoshitaka Fujihara, Ayako Isotani, Kazuo Inaba, Masahito Ikawa
- Journal Title
  
  Science
  
  Volume: 350 Issue: 6259 Pages: 442-445
- DOI
  10.1126/science.aad0836
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26830056, KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-25112007, KAKENHI-PROJECT-25250014, KAKENHI-PROJECT-15H05573, KAKENHI-PROJECT-15J03876, KAKENHI-PROJECT-15K14366, KAKENHI-PROJECT-26840061
[Journal Article] One-step generation of multiple transgenic mouse lines using an improved Pronuclear Injection-based Targeted Transgenesis (i-PITT)2015
- Author(s)
  Ohtsuka M., Miura H., Mochida K., Hirose M., Hasegawa A., Ogura A., Mizutani R., Kimura M., Isotani A., Ikawa M., Sato M. and Gurumurthy C. B.
- Journal Title
  
  BMC Genomics
  
  Volume: 16 Issue: 1 Pages: 274-274
- DOI
  10.1186/s12864-015-1432-5
- NAID
  120006957412
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24700435, KAKENHI-PROJECT-15K07695, KAKENHI-INTERNATIONAL-15K21737, KAKENHI-ORGANIZER-25112001, KAKENHI-PROJECT-25250014, KAKENHI-PROJECT-25290035
[Journal Article] CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines Identified Ccdc63 as Essential for Spermiogenesis2015
- Author(s)
  Samantha AM Young, Haruhiko Miyata, Yuhkoh Satouh, Hirotaka Kato, Kaori Nozawa, Ayako Isotani, R John Aitken, Mark A Baker, Masahito Ikawa
- Journal Title
  
  Int. J. Mol. Sci
  
  Volume: 16 Issue: 10 Pages: 24732-24750
- DOI
  10.3390/ijms161024732
- NAID
  120006957408
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26830056, KAKENHI-INTERNATIONAL-15K21737, KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-25112007, KAKENHI-PROJECT-25250014
[Journal Article] Induction of Primordial Germ Cell-Like Cells From Mouse Embryonic Stem Cells by ERK Signal Inhibition.2014
- Author(s)
  Kimura T, Kaga Y, Ohta H, Odamoto M, Sekita Y, Li K, Yamano N, Fujikawa K, Isotani A, Sasaki N, Toyoda M, Hayashi K, Okabe M, Shinohara T, Saitou M, Nakano T.
- Journal Title
  
  Stem Cells
  
  Volume: 32 Issue: 10 Pages: 2668-2678
- DOI
  10.1002/stem.1781
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24240066, KAKENHI-PROJECT-24390097, KAKENHI-PROJECT-24500490, KAKENHI-ORGANIZER-25112001, KAKENHI-PROJECT-25290033, KAKENHI-PROJECT-25293067
[Journal Article] Generation of mutant mice by pronuclear injection of circular plasmid expressing Cas9 and single guided RNA.2013
- Author(s)
  Mashiko D, Fujihara Y, Satouh Y, Miyata H, Isotani A, Ikawa M.
- Journal Title
  
  Scientific Reports
  
  Volume: 3: 3355 Issue: 1 Pages: 1-6
- DOI
  10.1038/srep03355
- NAID
  120006957396
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500490, KAKENHI-PROJECT-24700430, KAKENHI-PROJECT-24770210, KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-25112007, KAKENHI-PUBLICLY-25113714, KAKENHI-PROJECT-25250014
[Journal Article] SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia2012
- Author(s)
  Fujihara Y, Satouh Y, Inoue N, Isotani A, Ikawa M, Okabe M
- Journal Title
  
  Development
  
  Volume: 139 Issue: 19 Pages: 3583-9
- DOI
  10.1242/dev.081778
- NAID
  120006957401
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062008, KAKENHI-PROJECT-20670006, KAKENHI-PLANNED-21112006, KAKENHI-PROJECT-23500492, KAKENHI-PROJECT-24240066, KAKENHI-PROJECT-24500490, KAKENHI-PROJECT-24700430, KAKENHI-PROJECT-24770210, KAKENHI-PUBLICLY-23113510, KAKENHI-PUBLICLY-23116704
[Journal Article] Formation of a thymus from rat ES cells in xenogeneic nude mouse<--> rat ES chimeras2011
- Author(s)
  Isotani A., et al
- Journal Title
  
  Genes Cells
  
  Volume: 16 Issue: 4 Pages: 397-405
- DOI
  10.1111/j.1365-2443.2011.01495.x
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062008, KAKENHI-PROJECT-20670006, KAKENHI-PROJECT-22700454, KAKENHI-PUBLICLY-23113510, KAKENHI-PUBLICLY-23116704
[Journal Article] A homozygous mutant embryonic stem cell bank applicable for phenotype-driven genetic screening2011
- Author(s)
  Horie K.
- Journal Title
  
  Nature Methods
  
  Volume: 8 Issue: 12 Pages: 1071-1077
- DOI
  10.1038/nmeth.1739
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500388, KAKENHI-PUBLICLY-22116509, KAKENHI-PROJECT-22310118, KAKENHI-PROJECT-22700454, KAKENHI-PUBLICLY-23116704
[Journal Article] Formation of a thymus from rat ES cells in xenogeneic nude mouse〓rat ES chimeras.2011
- Author(s)
  Isotani A, et.al.
- Journal Title
  
  Genes to Cells
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062008
[Journal Article] Formation of a thymus from rat ES cells in xenogeneic nude mouse〓rat ES chimeras.2011
- Author(s)
  Isotani A, Hatayama H, Kaseda K, Ikawa M, Okabe M.
- Journal Title
  
  Genes to Cells
  
  Volume: (未定印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700454
[Journal Article] Formation of a thymus from rat ES cells in xenogeneic nude mouse-rat ES chimeras.2011
- Author(s)
  Isotani A, Hatayama H, Kaseda K, Ikawa M, Okabe M.
- Journal Title
  
  Genes to Cells 16(4)
  
  Pages: 397-405
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062008
[Journal Article] Meichroacidin containing the membrane occupation and recognition nexus motif is essential for spermatozoa morphogenesis2008
- Author(s)
  Tokuhiro K, Hirose M, Miyagawa Y, Tsujimura A, Irie S, Isotani A, Okabe M, Toyama Y, Ito C, Toshimori K, Takeda K, Oshio S, Tainaka H, Tsuchida J, Okuyama A, Nishimune Y, Tanaka H.
- Journal Title
  
  The Journal of Biological Chemistry 283
  
  Pages: 19039-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700368
[Journal Article] x-linked GFPマウスを用いた雌雄分別と生殖細胞の動態2007
- Author(s)
  磯谷綾子
- Journal Title
  
  蛋白質核酸酵素 52
  
  Pages: 2060-2066
- Data Source
  KAKENHI-PROJECT-19700368
[Presentation] マウスとラットの異種間キメラにおけるラット肺上皮細胞の解析2024
- Author(s)
  村田大和、由利俊祐、伊川正人、磯谷綾子
- Organizer
  第71回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-23K18577
[Presentation] 簡単な偽妊娠マウス作製法の検討2022
- Author(s)
  磯谷　綾子, Gema Puspa Sari
- Organizer
  第69回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-21K19267
[Presentation] 種特異的な発生時間によって制御される神経管のサイズ2022
- Author(s)
  笹井紀明白井学篠塚琢磨磯谷綾子
- Organizer
  第45回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03263
[Presentation] Ets2変異マウスの遺伝型と表現型への影響2019
- Author(s)
  岸本　裕樹、由利　俊祐、磯谷　綾子
- Organizer
  第66回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-16K07091
[Presentation] Ets2変異マウスの遺伝型と表現型への影響2019
- Author(s)
  岸本　裕樹、由利　俊祐、磯谷　綾子
- Organizer
  第66回日本実験動物学会総会
- Data Source
  KAKENHI-PUBLICLY-18H04885
[Presentation] 四倍体胚補完法によるES細胞由来マウス作製条件の検討2019
- Author(s)
  山本奈美、由利俊祐、磯谷綾子
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PUBLICLY-18H04885
[Presentation] Investigation of CRISPR/Cas9 system to obtain organ deficient mouse model2019
- Author(s)
  JONATHAN JUN-YONG LIM,Syunsuke Yuri, Ayako Isotani
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PUBLICLY-18H04885
[Presentation] How to ensure supply of donor organs for transplantation in the current clinical scenario2019
- Author(s)
  Ayako Isotani
- Organizer
  PHILIPPINE SOCIETY FOR DEVELOPMENTAL BIOLOGY 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04885
[Presentation] マウスとラットによる異種間キメラ動物の作出とその活用2018
- Author(s)
  磯谷　綾子
- Organizer
  第111回日本繁殖生物学会大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04885
[Presentation] 新たに樹立したEts2変異マウスの表現型の報告2018
- Author(s)
  岸本　裕樹、由利　俊祐、磯谷　綾子
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K07091
[Presentation] Application of a new animal model ”Interspecies Chimera”2018
- Author(s)
  Ayako Isotani
- Organizer
  NAIST-CU-TLL Trilateral Symposium 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07091
[Presentation] Application of a new animal model ”Interspecies Chimera”2018
- Author(s)
  Ayako Isotani
- Organizer
  NAIST-CU-TLL Trilateral Symposium 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04885
[Presentation] マウスとラットによる異種間キメラ動物の作出とその活用2018
- Author(s)
  磯谷　綾子
- Organizer
  第111回日本繁殖生物学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-16K07091
[Presentation] 「Generation of knockout rat through mouse<->rat chimera」2016
- Author(s)
  Isotani A, Yamagata K, Ikawa M, Okabe M
- Organizer
  International Symposium on “Epigenome dynamics and regulation in germ cells”
- Place of Presentation
  京都大学
- Year and Date
  2016-02-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14367
[Presentation] 「マウス<->ラット異種キメラが導く応用研究の可能性」2016
- Author(s)
  磯谷　綾子
- Organizer
  第9回ラットリソースリサーチ研究会
- Place of Presentation
  京都大学
- Year and Date
  2016-01-29
- Invited
- Data Source
  KAKENHI-PROJECT-15K14367
[Presentation] A trial to form an organ from ES cells --- a rat thymus in rat-nude mouse chimera.2012
- Author(s)
  磯谷　綾子
- Organizer
  第7回　研究所ネットワーク国際シンポジウム
- Place of Presentation
  東北大学加齢医学研究所
- Data Source
  KAKENHI-PROJECT-24500490
[Presentation] A trial to form an organ from ES cells --- a rat thymus in rat-nude mouse chimera.2012
- Author(s)
  磯谷　綾子
- Organizer
  第7回　研究所ネットワーク国際シンポジウム
- Place of Presentation
  東北大学加齢医学研究所
- Year and Date
  2012-06-14
- Data Source
  KAKENHI-PUBLICLY-23116704
[Presentation] マウスとラットの異種キメラの話。2012
- Author(s)
  磯谷　綾子
- Organizer
  第5回生殖若手の会
- Place of Presentation
  東京大学三崎臨海実験所
- Year and Date
  2012-07-26
- Data Source
  KAKENHI-PUBLICLY-23116704
[Presentation] マウスとラットの異種キメラの話2012
- Author(s)
  磯谷　綾子
- Organizer
  第5回生殖若手の会
- Place of Presentation
  東京大学三崎臨海実験所
- Data Source
  KAKENHI-PROJECT-24500490
[Presentation] 異種キメラ動物を使ってES細胞から臓器をつくる2011
- Author(s)
  磯谷綾子、畑山英、かせ田一宏、伊川正人、岡部勝
- Organizer
  第58回日本実験動物学会総会
- Place of Presentation
  東京
- Year and Date
  2011-05-25
- Data Source
  KAKENHI-PROJECT-22700454
[Presentation] 異種キメラ動物を使ってES細胞から臓器をつくる2011
- Author(s)
  磯谷綾子
- Organizer
  第58回日本実験動物学会総会
- Place of Presentation
  タワーホール船堀(東京)
- Year and Date
  2011-05-25
- Data Source
  KAKENHI-PUBLICLY-23116704
[Presentation] 異種キメラ動物を使ってES細胞から臓器をつくる2011
- Author(s)
  磯谷綾子
- Organizer
  第58回日本実験動物学会総会
- Place of Presentation
  タワーホール船堀(東京)
- Year and Date
  2011-05-25
- Data Source
  KAKENHI-PROJECT-22700454
[Presentation] A trial to form an organ from ES cells-a rat thymus in rat-nude mouse chimera-2011
- Author(s)
  磯谷綾子、畑山英、かせ田一宏、伊川正人、岡部勝
- Organizer
  平成22年度研究業績発表会
- Place of Presentation
  大阪
- Year and Date
  2011-01-21
- Data Source
  KAKENHI-PROJECT-22700454
[Presentation] マウス←ラットキメラを用いた臓器形成モデルの確立2010
- Author(s)
  磯谷綾子、畑山英、かせ田一宏、伊川正人、岡部勝
- Organizer
  第33回日本分子生物学会年会、第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-16
- Data Source
  KAKENHI-PROJECT-22700454
[Presentation] マウス←ラットキメラを用いた臓器形成モデルの確立2010
- Author(s)
  磯谷綾子
- Organizer
  第32回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-22700454
[Presentation] 雌雄キメラマウス用いた生殖細胞における性分化の解析2007
- Author(s)
  磯谷綾子
- Organizer
  第54回日本実験動物学会総会
- Place of Presentation
  東京
- Year and Date
  2007-05-23
- Data Source
  KAKENHI-PROJECT-19700368
[Presentation] マウス←ラットESキメラを介した遺伝子変異ラットの作出
- Author(s)
  磯谷　綾子
- Organizer
  第62回日本実験動物学会総会
- Place of Presentation
  京都テルサ
- Year and Date
  2015-05-28 – 2015-05-30
- Data Source
  KAKENHI-PROJECT-24500490

1. IKAWA Masahito (20304066)

# of Collaborated Projects: 6 results

# of Collaborated Products: 8 results
2. OKABE Masaru (30089875)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
3. FUJIHARA Yoshitaka (70578848)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
4. MIYATA Haruhiko (50604732)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
5. SATOUH Yuhkoh (40545571)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
6. 由利俊祐 (10800881)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
7. Sasai Noriaki (80391960)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. 本多新 (10373367)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. HASUWA Hidetoshi (50343249)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YAMAGATA Kazuo (10361312)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. Kiyozumi Daiji (70452430)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. MORI Masashi (00747941)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Shinkura Reiko (50362471)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 孫安生 (30447924)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 森田直樹 (80845107)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 的場章悟 (20585202)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 大田浩 (50391892)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 近藤亨 (30270573)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 別所康全 (70261253)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 白井学 (70294121)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. 森岡裕香 (00360264)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. NONAKA Shigenori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. OKADA Yuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 三浦浩美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 小鍛治俊也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. Lu Yonggang

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Isotani Ayako 磯谷 綾子

ISOTANI Ayako 磯谷 綾子

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異種間キメラ動体内で多能性幹細胞由来の子宮を作る研究Principal Investigator

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胎児の臓器を立体構造を保持したまま成体内で育てる研究Principal Investigator

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Study of recognition mechanism between mother and embryo using the xeno-hybrid placentaPrincipal Investigator

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A study of the dominance of sex differentiation in the sex chimeric rat modelPrincipal Investigator

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Development of a new treatment model for placental dysfunctionPrincipal Investigator

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A model of xenogeneic fetus pregnancy by the placenta replacement methodPrincipal Investigator

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Generation of knock out rat using mouse <-> rat chimeraPrincipal Investigator

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Isotani Ayako 磯谷綾子

ISOTANI Ayako 磯谷綾子

[Book] プログレッシブ　生命科学2014

[Book] プログレッシブ　生命科学2014

[Book] 蛋白質核酸酵素「生殖細胞の発生・エピジェネティクスと再プログラム化」2007