Inoshita Tsuyoshi 井下強

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INOSHITA Tsuyoshi 井下強

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Researcher Number	20601206
Other IDs
Affiliation (Current)	2025: 順天堂大学, 大学院医学研究科, 特任助教
Affiliation (based on the past Project Information) *help	2021 – 2023: 順天堂大学, 大学院医学研究科, 非常勤助教 2021 – 2022: 順天堂大学, 大学院医学研究科, 特任助教 2019 – 2020: 順天堂大学, 医学(系)研究科(研究院), 特任助教 2014 – 2019: 順天堂大学, 医学(系)研究科(研究院), 助教 2017: 順天堂大学, 医学研究科, 助教 2013 – 2014: 順天堂大学, 医学(系)研究科(研究院), 研究員 2012: 京都大学, 生命科学系キャリアパス形成ユニット, 研究員
Review Section/Research Field	Principal Investigator Basic Section 49010:Pathological biochemistry-related / Basic Section 51030:Pathophysiologic neuroscience-related / Neurology / Pathological medical chemistry / Applied entomology Except Principal Investigator Neurology / Pathological medical chemistry / Basic Section 49010:Pathological biochemistry-related
Keywords	Principal Investigator 神経科学 / パーキンソン病 / LRRK2 / 小胞輸送 / αシヌクレイン / ショウジョウバエ / グリア / Rab GTPase / リソソーム / シナプス機能制御 … More / 神経機能 / 軸索輸送 / 小胞動態 / 神経変性 / Vps35 / シナプス小胞 / 神経活動記録法 / 嗅覚情報処理機構 / フェロモン / 生体イメージング / 嗅覚 / 性フェロモン … More Except Principal Investigator パーキンソン病 / ショウジョウバエ / ミトコンドリア / iPS / Parkin / PINK1 / iPS細胞 / ドーパミン神経 / 創薬 / リン脂質 / 神経変性疾患 / シグナル伝達 / ドパミン神経 / CHCHD2 / ELOVL7 / PLA2G6 / 脂質解析 / リソソーム / 脂質 / α-Synuclein / 酵素 / 脳神経疾患 / スクリーニング / 遺伝性パーキンソン病 / mitophagy / マイトファジー / カルシウム / 光遺伝学 / カルシウムチャネル / カルシウムイメージング / alpha-Synuclein / メンブレンダイナミクス / 創薬探索 / シナプス小胞 / 神経シナプス / αシヌクレイン / キナーゼ / 神経変性 / 遺伝学 / 酸化ストレス / ユビキチン / リン酸化 Less

小胞輸送関連パーキンソン病原因遺伝子群が関与する共通の膜輸送機構の解明Principal Investigator
- Principal Investigator
  
  井下強
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Juntendo University
Elucidation of intracellular environmental factors that produce a risk for alpha-Synuclein seeding
- Principal Investigator
  
  Imai Yuzuru
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Juntendo University
Elucidation of molecular mechanisms of Parkinsons disease causative genes of a-synuclein aggregation and propagationPrincipal Investigator
- Principal Investigator
  
  Inoshita Tsuyoshi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Juntendo University
Exploration of Parkinson disease-specific pathological background
- Principal Investigator
  
  IMAI Yuzuru
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Juntendo University
Analysis of molecular mechanism of synaptic vesicle dynamics which regulated by Parkinson's disease causative genes and identification of therapeutic target of Parkinson's disease related genes.Principal Investigator
- Principal Investigator
  
  Inoshita Tsuyoshi
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
Drug screening to improve mitochondrial functions
- Principal Investigator
  
  Imai Yuzuru
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
A study on the common pathogenesis of Parkinson's disease as a mitochondrial disease
- Principal Investigator
  
  Imai Yuzuru
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Juntendo University
Establishment of mitophagy imaging methodPrincipal Investigator
- Principal Investigator
  
  Inoshita Tsuyoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Juntendo University
Elucidation of the mechanism of mitochondrial maintenance by Parkinson's disease gene products
- Principal Investigator
  
  SHIBA Kahori
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
in vivo live imaging for sex pheromone information presentation neural mechanism in Drosophila olfactionPrincipal Investigator
- Principal Investigator
  
  INOSHITA Tsuyoshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied entomology
- Research Institution
  Juntendo University
  Kyoto University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2012 Other

All Journal Article Presentation Book

[Book] Nova Biomedical.2017
- Author(s)
  Inoshita T, Imai Y
- Total Pages
  225
- Publisher
  Horizons in Neuroscience Research
- Data Source
  KAKENHI-PROJECT-26293070
[Book] Methods Mol Biol.2017
- Author(s)
  Imai Y, Inoshita T, Shiba-Fukushima K, Meng H, Hattori N
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-26293070
[Journal Article] Ubiquitination at the lysine 27 residue of the Parkin ubiquitin-like domain is suggestive of a new mechanism of Parkin activation.2022
- Author(s)
  Liu J-Y, Inoshita T, Shiba-Fukushima K, Yoshida K, Ishihama Y, Imai Y, Hattori N.
- Journal Title
  
  Hum Mol Genet.
  
  Volume: 31 Issue: 15 Pages: 2623-2638
- DOI
  10.1093/hmg/ddac064
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07910, KAKENHI-PROJECT-21H04820, KAKENHI-PROJECT-20H03453, KAKENHI-PROJECT-20K21531
[Journal Article] Parkinson disease-associated Leucine-rich repeat kinase regulates UNC-104-dependent axonal transport of Arl8-positive vesicles in Drosophila.2022
- Author(s)
  Inoshita T, Liu J-Y, Taniguchi D, Ishii R, Shiba-Fukushima K, Hattori N, Imai Y.
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 12 Pages: 105476-105476
- DOI
  10.1016/j.isci.2022.105476
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07910, KAKENHI-PROJECT-22K06916, KAKENHI-PROJECT-21H04820, KAKENHI-PROJECT-20H03453, KAKENHI-PROJECT-19K07830, KAKENHI-PROJECT-20K21531
[Journal Article] Syntaxin 17, an ancient SNARE paralog, plays different and conserved roles in different organisms2021
- Author(s)
  Kato Shun、Arasaki Kohei、Tokutomi Natsuki、Imai Yuzuru、Inoshita Tsuyoshi、Hattori Nobutaka、Sasaki Taeko、Sato Miyuki、Wakana Yuichi、Inoue Hiroki、Tagaya Mitsuo
- Journal Title
  
  Journal of Cell Science
  
  Volume: 134 Issue: 22
- DOI
  10.1242/jcs.258699
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19H05712, KAKENHI-PLANNED-20H05772, KAKENHI-PROJECT-20H03453, KAKENHI-PROJECT-21H02480, KAKENHI-PROJECT-20J01777, KAKENHI-PROJECT-20K21531, KAKENHI-PROJECT-23K21307
[Journal Article] A Cell-Based High-Throughput Screening Identified Two Compounds that Enhance PINK1-Parkin Signaling2020
- Author(s)
  Shiba-Fukushima Kahori、Inoshita Tsuyoshi、Sano Osamu、Iwata Hidehisa、Ishikawa Kei-ichi、Okano Hideyuki、Akamatsu Wado、Imai Yuzuru、Hattori Nobutaka
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 5 Pages: 101048-101048
- DOI
  10.1016/j.isci.2020.101048
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07873, KAKENHI-PROJECT-20K07910, KAKENHI-PROJECT-17H04049, KAKENHI-PROJECT-17K09765
[Journal Article] Reduced astrocytic reactivity in human brains and midbrain organoids with PRKN mutations2020
- Author(s)
  Kano Masayoshi、Takanashi Masashi、Oyama Genko、Yoritaka Asako、Hatano Taku、Shiba-Fukushima Kahori、Nagai Makiko、Nishiyama Kazutoshi、Hasegawa Kazuko、Inoshita Tsuyoshi、Ishikawa Kei-ichi、Akamatsu Wado、Imai Yuzuru、Bolognin Silvia、Schwamborn Jens Christian、Hattori Nobutaka
- Journal Title
  
  npj Parkinson's Disease
  
  Volume: 6 Issue: 1 Pages: 33-33
- DOI
  10.1038/s41531-020-00137-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07873, KAKENHI-PROJECT-20K07910, KAKENHI-PROJECT-17H04049, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-17K09765
[Journal Article] Identifying Therapeutic Agents for Amelioration of Mitochondrial Clearance Disorder in Neurons of Familial Parkinson Disease2020
- Author(s)
  Yamaguchi Akihiro、Ishikawa Kei-ichi、Inoshita Tsuyoshi、Shiba-Fukushima Kahori、Saiki Shinji、Hatano Taku、Mori Akio、Oji Yutaka、Okuzumi Ayami、Li Yuanzhe、Funayama Manabu、Imai Yuzuru、Hattori Nobutaka、Akamatsu Wado
- Journal Title
  
  Stem Cell Reports
  
  Volume: 14 Issue: 6 Pages: 1060-1075
- DOI
  10.1016/j.stemcr.2020.04.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08003, KAKENHI-PROJECT-20K07873, KAKENHI-PROJECT-20K07910, KAKENHI-PROJECT-17H04049, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-17K09765
[Journal Article] Regulation of membrane dynamics by Parkinson’s disease-associated genes.2018
- Author(s)
  Inoshita T, Cui C, Hattori N, Imai Y
- Journal Title
  
  J Genet.
  
  Volume: 97 Pages: 715-727
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04049
[Journal Article] Syntaxin 17 regulates the localization and function of PGAM5 in mitochondrial division and mitophagy2018
- Author(s)
  Sugo Masashi、Kimura Hana、Arasaki Kohei、Amemiya Toshiki、Hirota Naohiko、Dohmae Naoshi、Imai Yuzuru、Inoshita Tsuyoshi、Shiba‐Fukushima Kahori、Hattori Nobutaka、Cheng Jinglei、Fujimoto Toyoshi、Wakana Yuichi、Inoue Hiroki、Tagaya Mitsuo
- Journal Title
  
  The EMBO Journal
  
  Volume: 37 Issue: 21
- DOI
  10.15252/embj.201798899
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06138, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05902, KAKENHI-PROJECT-18H04023, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-17H04049, KAKENHI-PROJECT-18H02439, KAKENHI-PROJECT-18H02656
[Journal Article] Vps35 in cooperation with LRRK2 regulates synaptic vesicle endocytosis through the endosomal pathway in Drosophila.2017
- Author(s)
  1.Tsuyoshi Inoshita , Taku Arano, Yuka Hosaka, Hongrui Meng, Yujiro Umezaki, Sakiko Kosugi, Takako Morimoto, Masato Koike, Hui-Yun Chang, Yuzuru Imai, Nobutaka Hattori
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860219
[Journal Article] Reduced TDP-43 Expression Improves Neuronal Activities in a Drosophila Model of Perry Syndrome2017
- Author(s)
  Hosaka Y, Inoshita T, Shiba-Fukushima K, Cui C, Arano T, Imai Y, Hattori N
- Journal Title
  
  EBioMedicine
  
  Volume: 21 Pages: 218-227
- DOI
  10.1016/j.ebiom.2017.06.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293070
[Journal Article] Vps35 in cooperation with LRRK2 regulates synaptic vesicle endocytosis through the endosomal pathway in Drosophila2017
- Author(s)
  Inoshita Tsuyoshi、Arano Taku、Hosaka Yuka、Meng Hongrui、Umezaki Yujiro、Kosugi Sakiko、Morimoto Takako、Koike Masato、Chang Hui-Yun、Imai Yuzuru、Hattori Nobutaka
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 26 Issue: 15 Pages: 2933-2948
- DOI
  10.1093/hmg/ddx179
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09679, KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-17H04049
[Journal Article] Vps35 in cooperation with LRRK2 regulates synaptic vesicle endocytosis through the endosomal pathway in Drosophila2017
- Author(s)
  Tsuyoshi Inoshita , Taku Arano, Yuka Hosaka, Hongrui Meng, Yujiro Umezaki, Sakiko Kosugi, Takako Morimoto, Masato Koike, Hui-Yun Chang, Yuzuru Imai, Nobutaka Hattori
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09679
[Journal Article] Monitoring Mitochondrial Changes by Alteration of the PINK1-Parkin Signaling in Drosophila2017
- Author(s)
  Tsuyoshi Inoshita, Kahori Shiba-Fukushima, Hongrui Meng, Nobutaka Hattori, Yuzuru Imai
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 印刷中 Pages: 1-11
- DOI
  10.1007/7651_2017_9
- ISBN
  9781493977499, 9781493977505
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19525, KAKENHI-PROJECT-16K09679
[Journal Article] Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c.2017
- Author(s)
  Meng H, Yamashita C, Shiba-Fukushima K, Inoshita T, Funayama M, Sato S, Hatta T, Natsume T, Umitsu M, Takagi J, Imai Y, Hattori N.
- Journal Title
  
  Nat Commun
  
  Volume: 8 Issue: 1 Pages: 15500-15500
- DOI
  10.1038/ncomms15500
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09676, KAKENHI-PROJECT-16K19525, KAKENHI-PROJECT-26293070, KAKENHI-PROJECT-15H04842, KAKENHI-PROJECT-15KK0354, KAKENHI-PROJECT-17H01420
[Journal Article] Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson’s disease2017
- Author(s)
  Shiba-Fukushima Kahori、Ishikawa Kei-Ichi、Inoshita Tsuyoshi、Izawa Nana、Takanashi Masashi、Sato Shigeto、Onodera Osamu、Akamatsu Wado、Okano Hideyuki、Imai Yuzuru、Hattori Nobutaka
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 26 Pages: 3172-3185
- DOI
  10.1093/hmg/ddx201
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09677, KAKENHI-PROJECT-17K09765, KAKENHI-PROJECT-26293070, KAKENHI-PROJECT-15H04842, KAKENHI-PROJECT-26461280, KAKENHI-PROJECT-16K15484, KAKENHI-PROJECT-16K19524, KAKENHI-PUBLICLY-17H05706
[Journal Article] Regulation of vesicular trafficking by Parkinson’s disease-associated genes.2015
- Author(s)
  Tsuyoshi Inoshita, Yuzuru Imai
- Journal Title
  
  AIMS Molecular Science
  
  Volume: 2 Issue: 4 Pages: 461-475
- DOI
  10.3934/molsci.2015.4.461
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860219
[Journal Article] The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway.2015
- Author(s)
  Imai Y, Kobayashi Y, Inoshita T, Meng H, Arano T, Uemura K, Asano T, Yoshimi K, Zhang CL, Matsumoto G, Ohtsuka T, Kageyama R, Kiyonari H, Shioi G, Nukina N, Hattori N, Takahashi R
- Journal Title
  
  PLoS Genet.
  
  Volume: 11 Issue: 9 Pages: e1005503-e1005503
- DOI
  10.1371/journal.pgen.1005503
- NAID
  120005946994
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06773, KAKENHI-PROJECT-26860219, KAKENHI-PLANNED-23111002, KAKENHI-PUBLICLY-15H01561, KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-15H02540, KAKENHI-PROJECT-15H04842, KAKENHI-PROJECT-26670442
[Journal Article] PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila.2014
- Author(s)
  Shiba-Fukushima K, Inoshita T, Hattori N, Imai Y.
- Journal Title
  
  PLoS Genet.
  
  Volume: Jun 5;10(6) Issue: 6 Pages: 1004391-1004391
- DOI
  10.1371/journal.pgen.1004391
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-24390224, KAKENHI-PROJECT-24790896, KAKENHI-PUBLICLY-26117727, KAKENHI-PROJECT-26293070, KAKENHI-PROJECT-26461280, KAKENHI-PROJECT-26860219
[Journal Article] Lysine 63-linked polyubiquitination is dispensable for Parkin-mediated mitophagy.2014
- Author(s)
  Shiba-Fukushima K, Inoshita T, Hattori N, Imai Y.
- Journal Title
  
  J Biol Chem.
  
  Volume: 289 Issue: 48 Pages: 33131-6
- DOI
  10.1074/jbc.c114.580944
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-24390224, KAKENHI-PUBLICLY-26117727, KAKENHI-PROJECT-26293070, KAKENHI-PROJECT-26461280
[Journal Article] Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering.2014
- Author(s)
  Shiba-Fukushima K, Arano T, Matsumoto G, Inoshita T, Yoshida S, Ishihama Y, Ryu KY, Nukina N, Hattori N, Imai Y.
- Journal Title
  
  PLoS Genet.
  
  Volume: 10 Issue: 12 Pages: 1004861-1004861
- DOI
  10.1371/journal.pgen.1004861
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-23500434, KAKENHI-PROJECT-24241062, KAKENHI-PROJECT-24390224, KAKENHI-PUBLICLY-26117727, KAKENHI-PROJECT-26293070, KAKENHI-PROJECT-26461280, KAKENHI-PROJECT-26860219
[Journal Article] PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila2014
- Author(s)
  Kahori Shiba-Fukushima, Tsuyoshi Inoshita, Nobutaka Hattori, Yuzuru Imai
- Journal Title
  
  Plos genetics
  
  Volume: 電子媒体
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24780048
[Presentation] Characterization of CHCHD2 variants linked to amyotrophic lateral sclerosis and Parkinson’s disease.2023
- Author(s)
  Ikeda A, Funayama M, Yoshida M, Li Y, Yoshino　H, Inoshita T, Shiba-Fukushima K, Meng H, Amo T, Aiba I, Saito Y, Atsuta N, Nakamura R, Tohnai G, Sone J, Saito Y, Murayama S, Izumi Y, Kaji R, Morita M, Taniguchi A, Nishioka K, Imai Y, Sobue G, Hattori N,
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K06916
[Presentation] Drosophila VPS13 regulates neuronal synaptic activity and mitochondrial homeostasis.2022
- Author(s)
  Shiba-Fukushima K, Inoshita T, Imai Y, Hattori N
- Organizer
  Neuro2022
- Data Source
  KAKENHI-PROJECT-20H03453
[Presentation] Ubiquitination at the lysine 27 residue of the Parkin ubiquitin-like domain is suggestive of a new mechanism of Parkin activation.2022
- Author(s)
  Liu J-Y, Inoshita T, Shiba-Fukushima K, Hattori N, Imai Y
- Organizer
  Neuro2022
- Data Source
  KAKENHI-PROJECT-20H03453
[Presentation] Screening of lipid species and associated enzymes that participate in α-synuclein aggregation.2022
- Author(s)
  Kasahara R, Ogata J, Shiina K, Shiba-Fukushima K, Inoshita T, Hattori N, Imai Y
- Organizer
  MBSJ2022
- Data Source
  KAKENHI-PROJECT-20H03453
[Presentation] Two novel variants in CHCHD2 associate with TDP-43 pathology among amyotrophic lateral sclerosis.2022
- Author(s)
  Ikeda A, Funayama M, Yoshida M, Li Y, Inoshita T, Shiba-Fukushima K, Meng H, Amo T, Aiba I, Saito Y, Atsuta N, Nakamura R, Tohnai G, Sone J, Izumi Y, Kaji R, Morita M, Taniguchi A, Nishioka K, Imai Y, Sobue G, Hattori N, JaCALS
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20H03453
[Presentation] Parkinson’s disease-associated genes regulate a-Synuclein turnover through the dynamics of a small GTPase Arl-8 at synapses.2019
- Author(s)
  Inoshita T, Liu J, Taniguchi D, Cui C, Takanashi M Imai Y, Hattori N
- Organizer
  第42回日本分子生物学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07830
[Presentation] パーキンソン病関連遺伝子はsmall GTPase, Arl-8の動態制御を介しα-シヌクレインのターンオーバーを調節する。2019
- Author(s)
  井下　強、劉　俊逸、谷口　大祐、高梨　雅史、今居　譲、服部　信孝
- Organizer
  第13回パーキンソン病・運動障害性疾患コングレス
- Data Source
  KAKENHI-PROJECT-19K07830
[Presentation] パーキンソン病関連遺伝子はsmall GTPase, Arl-8の動態制御を介しα-シヌクレインのターンオーバーを調節する。2019
- Author(s)
  井下　強、劉　俊逸、谷口　大祐、高梨　雅史、今居　譲、服部　信孝
- Organizer
  第13回パーキンソン病・運動障害性疾患コングレス
- Data Source
  KAKENHI-PROJECT-16K09679
[Presentation] Parkinson’s disease-associated genes regulate the quality control of α-synuclein at presynapses through the endo-lysosomal pathway.2019
- Author(s)
  Inoshita T, Liu J, Taniguchi D, Cui C, Takanashi M Imai Y, Hattori N
- Organizer
  第42回日本神経学会学術大会 
- Data Source
  KAKENHI-PROJECT-16K09679
[Presentation] Parkinson’s disease-associated genes regulate a-Synuclein turnover through the dynamics of a small GTPase Arl-8 at synapses.2019
- Author(s)
  Inoshita T, Liu J, Taniguchi D, Cui C, Takanashi M Imai Y, Hattori N
- Organizer
  第42回日本分子生物学会学術大会
- Data Source
  KAKENHI-PROJECT-16K09679
[Presentation] 光遺伝学的手法の導入はパーキンソン病モデルショウジョウバエのドーパミン神経活動を改善する2018
- Author(s)
  井下　強
- Organizer
  第41回　分子生物学会
- Data Source
  KAKENHI-PROJECT-16K09679
[Presentation] Introduction of photoenergetic mitochondria improves neuronal activity of dopaminergic neurons in Drosophila model of mitochondria-associated Parkinson’s disease2018
- Author(s)
  井下　強
- Organizer
  第41回　神経科学学会
- Data Source
  KAKENHI-PROJECT-16K09679
[Presentation] PINK1-Parkinシグナル伝達に関与する新規分子の解析2017
- Author(s)
  柴佳保里、井下強、青木裕子、石濱泰、今居譲、服部信孝
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-17H04049
[Presentation] Reduced TDP-43 expression improves axonal transport and synaptic activity in a Drosophila model of Perry syndrome2017
- Author(s)
  Hosaka Y, Inoshita T, Cui C, Arano T, Shiba K, Imai Y, Hattori H
- Organizer
  World Congress of Neurology
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] PINK1-Parkinシグナル伝達に関与する新規分子の解析2017
- Author(s)
  柴佳保里、井下強、青木裕子、石濱泰、今居譲、服部信孝
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] Genetic association study of Parkinson's disease-related genes that control synaptic vesicle dynamics2017
- Author(s)
  崔長旭、井下強、服部信孝、今居譲
- Organizer
  第40回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17H04049
[Presentation] Vps35 in cooperation with LRRK2 regulates synaptic vesicle recycling through the endosomal pathway2017
- Author(s)
  井下強、崔長旭、荒野拓、穂坂有加、孟紅蕊、梅崎勇次郎、小杉紗紀子、森本高子、小池正人、Chang Hui-Yun、今居譲、服部信孝
- Organizer
  第40回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17H04049
[Presentation] パーキンソン病原因遺伝子 Vps35はシナプス小胞再生関連遺伝子と協働して神経伝達を制御する2017
- Author(s)
  井下強、荒野拓、穂坂有加、孟紅蕊、梅崎勇次郎、小杉紗紀子、森本高子、小池正人、Chang Hui-Yun、今居譲、服部信孝
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-16K09679
[Presentation] パーキンソン病原因遺伝子 Vps35はシナプス小胞再生関連遺伝子と協働して神経伝達を制御する2017
- Author(s)
  井下強、荒野拓、穂坂有加、孟紅蕊、梅崎勇次郎、小杉紗紀子、森本高子、小池正人、Chang Hui-Yun、今居譲、服部信孝
- Organizer
  ConBio2017
- Invited
- Data Source
  KAKENHI-PROJECT-17H04049
[Presentation] PINK1-Parkinシグナル伝達に関与する新規分子の解析2017
- Author(s)
  柴佳保里、井下強、青木裕子、石濱泰、今居譲、服部信孝
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-16K15484
[Presentation] Vps35 in cooperation with LRRK2 regulates synaptic vesicle recycling through the endosomal pathway2017
- Author(s)
  井下強、崔長旭、荒野拓、穂坂有加、孟紅蕊、梅崎勇次郎、小杉紗紀子、森本高子、小池正人、Chang Hui-Yun、今居譲、服部信孝
- Organizer
  第40回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-16K09679
[Presentation] Loss of Parkinson’s disease-associated protein CHCHD2 affects mitochondrial cristae structure and facilitates cytochrome c release from mitochondria2017
- Author(s)
  Meng H, Yamashita C, Shiba-Fukushima K, Inoshita T, Imai Y, Hattori N
- Organizer
  第40回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] パーキンソン病原因遺伝子の一部は、シナプス小胞動態を制御する2016
- Author(s)
  井下　強、荒野　拓、穂坂　有加、孟　紅蕊、梅崎　勇次郎、小杉　紗紀子、森本　高子、小池　正人、Hui-Yun Chang、今居　譲、服部　信孝
- Organizer
  第39回分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-26860219
[Presentation] Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson’s disease.2016
- Author(s)
  Shiba K, Ishikawa K, Inoshita T, Akamatsu W, Hideyuki O, Imai Y, Hattori N
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26461280
[Presentation] Loss of Parkinson’s disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c.2016
- Author(s)
  Meng H, Yamashita C, Shiba-Fukushima K, Inoshita T, Funayama M, Sato S, Imai Y, Hattori N
- Organizer
  第39回日本分子生物学会年会　シンポジウム
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] パーキンソン病新規原因遺伝子CHCHD2の機能解析2016
- Author(s)
  山下力、孟　紅蕊、井下強、福嶋佳保里、荒野拓、佐藤栄人、今居譲、服部信孝
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] Synaptic vesicle dynamics are regulated by Parkinson’s disease-associated proteins Vps35 and LRRK22016
- Author(s)
  Tsuyoshi Inoshita, Yuka Hosaka, Yuzuru Imai, Nobutaka Hattori
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-26860219
[Presentation] 小胞輸送と神経分泌を制御するパーキンソン病関連遺伝子のスクリーニング2016
- Author(s)
  崔　長旭、井下　強、服部　信孝、今居　譲
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] パーキンソン病原因遺伝子によるシナプス小胞動態制御2016
- Author(s)
  井下　強、荒野　拓、穂坂　有加、孟　紅蕊、梅崎　勇次郎、小杉　紗紀子、森本　高子、小池　正人、Hui-Yun Chang、服部　信孝、今居　譲
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] Synaptic vesicle dynamics are regulated by a subset of Parkinson’s disease genes.2016
- Author(s)
  Tsuyoshi Inoshita, Changxu Cui, Yuzuru Imai、 Nobutaka Hattori
- Organizer
  第３９回日本神経科学大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-26860219
[Presentation] パーキンソン病原因遺伝子の一部は、シナプス小胞動態を制御する2016
- Author(s)
  井下　強、荒野　拓、穂坂　有加、孟　紅蕊、梅崎　勇次郎、小杉　紗紀子、森本　高子、小池　正人、Hui-Yun Chang、今居　譲、服部　信孝
- Organizer
  第39回分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-16K09679
[Presentation] CHCHD2, a Parkinson's-Disease Associated Protein, Regulates the Mitochondrial cristae integrity and function in Drosophila2016
- Author(s)
  Meng H, Yamashita C, Shiba-Fukushima K, Inoshita T, Imai Y, Hattori N
- Organizer
  第39回日本神経学会学術大会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] Synaptic vesicle dynamics are regulated by a subset of Parkinson’s disease genes2016
- Author(s)
  Inoshita T, Cui C, Hattori N, Imai Y
- Organizer
  第39回日本神経学会学術大会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering2015
- Author(s)
  Shiba-Fukushima K, Arano T, Matsumoto G, Inoshita T, Yoshida S, Ishihama Y, Ryu K-K, Nukina N, Imai Y, Hattori N
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ（新潟県新潟市）
- Year and Date
  2015-05-23
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] Synaptic vesicle dynamics are regulated by a subset of Parkinson’s disease genes2015
- Author(s)
  井下　強
- Organizer
  第３８回日本神経科学大会
- Place of Presentation
  神戸・兵庫県
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-26860219
[Presentation] Parkinson’s disease-associated proteins Vps35 and LRRK2 regulate synaptic release2015
- Author(s)
  井下　強
- Organizer
  第５６回日本神経学会学術大会
- Place of Presentation
  新潟・新潟県
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-26860219
[Presentation] PINK1-Parkinミトコンドリア品質管理機構に関与する分子の探索2014
- Author(s)
  柴佳保里、井下　強、梅崎勇次郎、今居　譲、服部信孝
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡国際会議場（福岡県・福岡市）
- Year and Date
  2014-05-23
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] Lysine 63-linked polyubiquitination is dispensable for Parkin-mediated mitophagy2014
- Author(s)
  Shiba-Fukushima K, Inoshita T, Hattori N, Imai Y
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-PROJECT-26461280
[Presentation] PINK1-Parkinミトコンドリア品質管理機構に関与する分子の探索2014
- Author(s)
  柴佳保里、井下　強、梅崎勇次郎、今居　譲、服部信孝
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡
- Year and Date
  2014-05-23
- Data Source
  KAKENHI-PROJECT-26461280
[Presentation] Lysine 63-linked polyubiquitination is dispensable for Parkin-mediated mitophagy2014
- Author(s)
  Shiba-Fukushima K, Inoshita T, Hattori N, Imai Y
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜）
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] Olfactory discrimination od diverse pheromone profiles on reproductive status2012
- Author(s)
  井下　強
- Organizer
  Neurofly 2012
- Place of Presentation
  Italia, Padva
- Data Source
  KAKENHI-PROJECT-24780048
[Presentation] ドーパミン分泌の生体内ライブイメージング
- Author(s)
  井下　強
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡市　福岡国際会議場
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26860219
[Presentation] パーキンソン病原因遺伝子産物Vps35とLRRK2は、小胞輸送と神経分泌を制御する
- Author(s)
  井下　強
- Organizer
  第３７回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜・横浜市
- Year and Date
  2014-11-26 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24780048
[Presentation] Parkinson’s disease-associated protein Vps35 regulates neuronal activities, which are modulated by Parkinson’s-disease associated protein kinase LRRK2
- Author(s)
  井下　強
- Organizer
  第３７回日本神経科学大会
- Place of Presentation
  横浜市　パシフィコ横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-26860219

1. IMAI Yuzuru (30321730)

# of Collaborated Projects: 6 results

# of Collaborated Products: 29 results
2. SHIBA Kahori (30468582)

# of Collaborated Projects: 6 results

# of Collaborated Products: 22 results
3. HATTORI Nobutaka (80218510)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
4. ARANO Taku (80750091)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
5. EJIMA Aki (00548571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MENG Hongrui (90736498)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
7. ISHIHAMA Yasushi (30439244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. AKAMATSU Wado (60338184)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. OHBA Yusuke (30333503)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. FUNAYAMA Manabu

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. 井上弘樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 佐藤美由紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 石川景一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
14. 斉木臣二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 大塚俊之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Inoshita Tsuyoshi 井下 強

INOSHITA Tsuyoshi 井下 強

Research Projects

Research Products

Co-Researchers

小胞輸送関連パーキンソン病原因遺伝子群が関与する共通の膜輸送機構の解明Principal Investigator

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Elucidation of intracellular environmental factors that produce a risk for alpha-Synuclein seeding

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Review Section

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Elucidation of molecular mechanisms of Parkinsons disease causative genes of a-synuclein aggregation and propagationPrincipal Investigator

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Review Section

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Exploration of Parkinson disease-specific pathological background

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Analysis of molecular mechanism of synaptic vesicle dynamics which regulated by Parkinson's disease causative genes and identification of therapeutic target of Parkinson's disease related genes.Principal Investigator

Principal Investigator

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Drug screening to improve mitochondrial functions

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A study on the common pathogenesis of Parkinson's disease as a mitochondrial disease

Principal Investigator

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Establishment of mitophagy imaging methodPrincipal Investigator

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Elucidation of the mechanism of mitochondrial maintenance by Parkinson's disease gene products

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in vivo live imaging for sex pheromone information presentation neural mechanism in Drosophila olfactionPrincipal Investigator

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[Book] Nova Biomedical.2017

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[Book] Methods Mol Biol.2017

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[Journal Article] Ubiquitination at the lysine 27 residue of the Parkin ubiquitin-like domain is suggestive of a new mechanism of Parkin activation.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Parkinson disease-associated Leucine-rich repeat kinase regulates UNC-104-dependent axonal transport of Arl8-positive vesicles in Drosophila.2022

Inoshita Tsuyoshi 井下強

INOSHITA Tsuyoshi 井下強