Kajino Rie 梶野リエ

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KAJINO Rie 梶野リエ

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Researcher Number	20633184
Other IDs
Affiliation (Current)	2025: 愛知県がんセンター(研究所), がん病態生理学分野, 主任研究員
Affiliation (based on the past Project Information) *help	2021 – 2025: 愛知県がんセンター(研究所), がん病態生理学分野, 主任研究員 2018 – 2020: 愛知県がんセンター(研究所), がん病態生理学分野, 研究員 2017: 愛知県がんセンター(研究所), 分子病態学部｀, 研究員 2012 – 2016: 愛知県がんセンター(研究所), 分子病態学部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Tumor biology / Tumor biology Except Principal Investigator Basic Section 50010:Tumor biology-related / Tumor biology
Keywords	Principal Investigator 大腸がん / 合成致死 / 免疫学 / オルガノイド / KRAS変異 / 大腸腫瘍オルガノイド / 大腸がんマウスモデル / オルガノイド培養 / マウスモデル / Apc変異 … More / 神経 / 免疫 / シグナル伝達 / 癌 … More Except Principal Investigator 大腸がん / マウスモデル / 転移 / がん幹細胞 / スプライシング / 未分化性 / RNA修飾 / プロテオミクス / 翻訳後修飾 / プロテオーム解析 / マルチオミクス解析 / 上皮間葉転換 / 動物実験 / 遺伝子改変マウス / トランスポゾン / RNA結合タンパク Less

Molecular mechanisms maintaining the undifferntiated state of colorectal cancer stem cells
- Principal Investigator
  
  青木正博
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Aichi Cancer Center Research Institute
Wnt経路とMyD88との合成致死性を利用した新規大腸がん治療標的因子の検証Principal Investigator
- Principal Investigator
  
  梶野リエ
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Aichi Cancer Center Research Institute
The role and molecular mechanism of NAT10, an RNA-modifying enzyme, in colorectal cancer.
- Principal Investigator
  
  三城恵美 (佐藤恵美)
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Nagoya University
Molecular mechanisms that maintain stemness in metastatic colorectal cancer
- Principal Investigator
  
  青木正博
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Aichi Cancer Center Research Institute
Identification of novel therapeutic targets for colorectal cancer with KRAS mutations by MyD88 inhibition.Principal Investigator
- Principal Investigator
  
  Kajino Rie
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Aichi Cancer Center Research Institute
Elucidation of the role of MyD88 in Apc mutant intestinal tumor epithelial cellsPrincipal Investigator
- Principal Investigator
  
  Kajino Rie
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Aichi Cancer Center Research Institute
Molecular mechanisms and preventive/therapeutic targets of colon cancer metastasis
- Principal Investigator
  
  AOKI MASAHIRO
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Aichi Cancer Center Research Institute
Elucidating the mechanisms of colorectal cancer metastasis using mouse models
- Principal Investigator
  
  Aoki Masahiro
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Aichi Cancer Center Research Institute
Analysis of the role of nervous and immune system interactions in development of colon cancerPrincipal Investigator
- Principal Investigator
  
  Kajino Rie
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Aichi Cancer Center Research Institute
Analysis of the role of immune system in intestinal carcinogenesis and metastasis using a mouse modelPrincipal Investigator
- Principal Investigator
  
  KAJINO Rie
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Tumor biology
- Research Institution
  愛知県がんセンター(研究所)

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014

All Journal Article Presentation

[Journal Article] Decreased liver B vitamin-related enzymes as a metabolic hallmark of cancer cachexia2023
- Author(s)
  Kojima Yasushi、Mishiro-Sato Emi、Fujishita Teruaki、Satoh Kiyotoshi、Kajino-Sakamoto Rie、Oze Isao、Nozawa Kazuki、Narita Yukiya、Ogata Takatsugu、Matsuo Keitaro、Muro Kei、Taketo Makoto Mark、Soga Tomoyoshi、Aoki Masahiro
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 1-23
- DOI
  10.1038/s41467-023-41952-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06624, KAKENHI-PROJECT-21K07140, KAKENHI-ORGANIZER-23H04939, KAKENHI-PROJECT-22H04923, KAKENHI-PROJECT-23K24170
[Journal Article] L-2hydroxyglutaric acid rewires amino acid metabolism in colorectal cancer via the mTOR-ATF4 axis2023
- Author(s)
  Tabata Sho、Kojima Yasushi、Sakamoto Takeharu、Igarashi Kaori、Umetsu Ko、Ishikawa Takamasa、Hirayama Akiyoshi、Kajino-Sakamoto Rie、Sakamoto Naoya、Yasumoto Ken-ichi、Okano Keiichi、Suzuki Yasuyuki、Yachida Shinichi、Aoki Masahiro、Soga Tomoyoshi
- Journal Title
  
  Oncogene
  
  Volume: 42 Issue: 16 Pages: 1294-1307
- DOI
  10.1038/s41388-023-02632-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07150, KAKENHI-PROJECT-19K07659, KAKENHI-PROJECT-17KK0199, KAKENHI-PROJECT-22K19464, KAKENHI-ORGANIZER-23H04939, KAKENHI-PROJECT-23K24170, KAKENHI-PROJECT-23K28008
[Journal Article] The cAMP/PKA/CREB and TGFβ/SMAD4 Pathways Regulate Stemness and Metastatic Potential in Colorectal Cancer Cells2022
- Author(s)
  Fujishita Teruaki、Kojima Yasushi、Kajino-Sakamoto Rie、Mishiro-Sato Emi、Shimizu Yasuhiro、Hosoda Waki、Yamaguchi Rui、Taketo Makoto Mark、Aoki Masahiro
- Journal Title
  
  Cancer Research
  
  Volume: 82 Issue: 22 Pages: 4179-4190
- DOI
  10.1158/0008-5472.can-22-1369
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19456, KAKENHI-PROJECT-20K07440, KAKENHI-PROJECT-23K24170, KAKENHI-PROJECT-22H04923
[Journal Article] Synthetic lethality between MyD88 loss and mutations in Wnt/β-catenin pathway in intestinal tumor epithelial cells2021
- Author(s)
  Rie Kajino-Sakamoto, Teruaki Fujishita, Makoto Mark Taketo, Masahiro Aoki
- Journal Title
  
  Oncogene
  
  Volume: 40 Issue: 2 Pages: 408-420
- DOI
  10.1038/s41388-020-01541-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07440, KAKENHI-PROJECT-18H02686, KAKENHI-PROJECT-18K07254, KAKENHI-PROJECT-16H06277
[Journal Article] Stromal iodothyronine deiodinase 2 ( DIO 2) promotes the growth of intestinal tumors in Apc Δ716 mutant mice2019
- Author(s)
  Kojima Yasushi、Kondo Yuriko、Fujishita Teruaki、Mishiro‐Sato Emi、Kajino‐Sakamoto Rie、Taketo Makoto Mark、Aoki Masahiro
- Journal Title
  
  Cancer Science
  
  Volume: 110 Issue: 8 Pages: 2520-2528
- DOI
  10.1111/cas.14100
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02686, KAKENHI-PROJECT-17K07191
[Journal Article] Tumor microenvironment confers mTOR inhibitor resistance in invasive intestinal adenocarcinoma2017
- Author(s)
  Fujishita T, Kojima Y, Kajino-Sakamoto R, Taketo MM, Aoki M.
- Journal Title
  
  Oncogene
  
  Volume: 36 Issue: 46 Pages: 6480-6489
- DOI
  10.1038/onc.2017.242
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07139, KAKENHI-PROJECT-26290045, KAKENHI-PLANNED-26111005
[Journal Article] Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC2017
- Author(s)
  Satoh K, Yachida S, Sugimoto M, Oshima M, Nakagawa T, Akamoto S, Tabata S, Saitoh K, Kato K, Sato S, Igarashi K, Aizawa Y, Kajino-Sakamoto R, Kojima Y, Fujishita T, Enomoto A, Hirayama A, Ishikawa T, Taketo MM, Kushida Y, Haba R, Okano K, Tomita M, Suzuki Y, Fukuda S, Aoki M, Soga T.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 114 Issue: 37
- DOI
  10.1073/pnas.1710366114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07139, KAKENHI-PROJECT-16K21361, KAKENHI-PROJECT-26290045, KAKENHI-PUBLICLY-17H05654, KAKENHI-PLANNED-26111005, KAKENHI-PROJECT-26462860, KAKENHI-PROJECT-15K21364
[Journal Article] Antitumor activity of the MEK inhibitor trametinib on intestinal polyp formation in ApcΔ716 mice involves stromal COX-2.2015
- Author(s)
  Fujishita T, Kajino-Sakamoto R, Kojima Y, Taketo MM, Aoki M.
- Journal Title
  
  Cancer Science
  
  Volume: 5（予定） Issue: 6 Pages: 692-699
- DOI
  10.1111/cas.12670
- NAID
  120005767023
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26830090, KAKENHI-PLANNED-26111005, KAKENHI-PROJECT-25253022, KAKENHI-PROJECT-26290045
[Presentation] Exploring therapeutic targets for colorectal cancer using synthetic lethality of MyD88 loss and Wnt pathway mutations2023
- Author(s)
  梶野　リエ
- Organizer
  第82回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07114
[Presentation] Wnt経路に変異を持つ腸管腫瘍細胞においてMyD88の機能抑制が合成致死をもたらすメカニズムの解明2022
- Author(s)
  梶野　リエ
- Organizer
  第81回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07114
[Presentation] 大腸腫瘍組織における翻訳後修飾変化の解析2021
- Author(s)
  三城恵美、藤下晃章、小島康、梶野リエ、田中努、田近正洋、青木正博
- Organizer
  日本プロテオーム学会2021年大会
- Data Source
  KAKENHI-PROJECT-18H02686
[Presentation] Dual role of epithelial MyD88 in Apc-mutant intestinal tumors.2020
- Author(s)
  梶野リエ、藤下晃章、武藤誠、青木正博
- Organizer
  The AACR Virtual Annual Meeting II
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02686
[Presentation] MyD88 によるApc 変異腸上皮細胞の合成致死メカニズムの解明2019
- Author(s)
  梶野リエ、藤下晃章、武藤　誠、青木正博
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02686
[Presentation] 腸管腫瘍形成におけるDio2(2 型脱ヨード酵素）の生物学的役割2019
- Author(s)
  小島　康、藤下晃章、梶野リエ、三城恵美、武藤　誠、青木正博
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02686
[Presentation] Synthetic lethality between Apc mutation and MyD88 loss in intestinal tumor epithelial cells2019
- Author(s)
  梶野リエ、藤下晃章、武藤誠、青木正博
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07254
[Presentation] Apc変異マウスの腸管腫瘍形成において腸上皮細胞のMyD88が果たす役割の解明2018
- Author(s)
  梶野リエ、藤下晃章、武藤誠、青木正博
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02686
[Presentation] Apc変異マウスの腸管腫瘍形成において腸上皮細胞のMyD88が果たす役割の解明2018
- Author(s)
  梶野リエ、藤下晃章、武藤誠、青木正博
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07254
[Presentation] Apc+/Δ716マウスの腸管腫瘍形成において腸上皮細胞のMyD88が果たす役割の解析2017
- Author(s)
  梶野リエ、藤下晃章、武藤誠、青木正博
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-26290045
[Presentation] II型脱ヨード酵素の大腸がん進展における役割2016
- Author(s)
  小島康、今度ゆりこ、藤下晃章、梶野リエ、武藤誠、青木正博
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Data Source
  KAKENHI-PROJECT-26290045
[Presentation] 大腸がんマウスモデルとオルガノイド培養を用いた腫瘍形成における低酸素シグナルの役割の解明2016
- Author(s)
  梶野リエ、青木正博
- Organizer
  第14回がんとハイポキシア研究会
- Place of Presentation
  岐阜グランドホテル（岐阜県・岐阜市）
- Data Source
  KAKENHI-PROJECT-26290045
[Presentation] がん微小環境は浸潤性腸がんのmTOR阻害薬抵抗性獲得に関与する2016
- Author(s)
  藤下晃章、梶野リエ、小島康、武藤誠、青木正博
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Data Source
  KAKENHI-PROJECT-26290045
[Presentation] 腸管腫瘍形成における JNK-mTORC1 経路活性化と神経伝達物質の関連の解明2016
- Author(s)
  梶野リエ、藤下晃章、武藤誠、青木正博
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Data Source
  KAKENHI-PROJECT-26290045
[Presentation] MEK/ERK経路の阻害はCOX2およびCCL2の発言レベルを減少させ腸管ポリープ形成を抑制する2015
- Author(s)
  藤下晃章、梶野リエ、小島康、武藤誠、青木正博
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県・名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26290045
[Presentation] 腸管腫瘍形成におけるJNK-mTORC1経路活性化機序の解析2015
- Author(s)
  梶野リエ、藤下晃章、小島康、武藤誠、青木正博
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県・名古屋市）
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-26290045
[Presentation] Analysis of the mechanisms of JNK-mTORC1 pathway activation during intestinal tumorigenesis2015
- Author(s)
  梶野リエ
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26830091
[Presentation] MEK阻害薬トラメチニブによる Apc 変異マウスの腸管ポリープ形成抑制効果2014
- Author(s)
  青木正博、梶野リエ、武藤誠、藤下晃章
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-26290045
[Presentation] 腸管腫瘍形成におけるJNK-mTORC１経路活性化機序の解析2014
- Author(s)
  梶野リエ
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2014-09-27
- Data Source
  KAKENHI-PROJECT-26830091
[Presentation] Apc+/Δ716マウスの腸管腫瘍におけるJNK-mTORC1経路活性化機序の解析2014
- Author(s)
  梶野　リエ、藤下晃章、小島　康、武藤　誠、青木　正博
- Organizer
  第37会日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2014-11-25
- Data Source
  KAKENHI-PROJECT-26290045
[Presentation] Apc+/Δ716マウスの腸管腫瘍におけるJNK-mTORC１経路活性化機序の解析2014
- Author(s)
  梶野リエ
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2014-11-25
- Data Source
  KAKENHI-PROJECT-26830091
[Presentation] 腸管腫瘍形成における JNK-mTORC1 経路活性化機序の解析2014
- Author(s)
  梶野　リエ、藤下晃章、小島　康、武藤　誠、青木　正博
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2014-09-27
- Data Source
  KAKENHI-PROJECT-26290045

1. Aoki Masahiro (60362464)

# of Collaborated Projects: 5 results

# of Collaborated Products: 17 results
2. 藤下晃章 (50511870)

# of Collaborated Projects: 5 results

# of Collaborated Products: 20 results
3. 小島康 (30464217)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
4. 三城恵美 (00455544)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
5. 佐久間圭一朗 (90402891)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. TAKEDA Junji (50163407)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TABATA Sho

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. SAKAMOTO Takeharu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 曽我朋義

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kajino Rie 梶野 リエ

KAJINO Rie 梶野 リエ

Research Projects

Research Products

Co-Researchers

Molecular mechanisms maintaining the undifferntiated state of colorectal cancer stem cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Wnt経路とMyD88との合成致死性を利用した新規大腸がん治療標的因子の検証Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role and molecular mechanism of NAT10, an RNA-modifying enzyme, in colorectal cancer.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms that maintain stemness in metastatic colorectal cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of novel therapeutic targets for colorectal cancer with KRAS mutations by MyD88 inhibition.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the role of MyD88 in Apc mutant intestinal tumor epithelial cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms and preventive/therapeutic targets of colon cancer metastasis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating the mechanisms of colorectal cancer metastasis using mouse models

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the role of nervous and immune system interactions in development of colon cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the role of immune system in intestinal carcinogenesis and metastasis using a mouse modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Decreased liver B vitamin-related enzymes as a metabolic hallmark of cancer cachexia2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] L-2hydroxyglutaric acid rewires amino acid metabolism in colorectal cancer via the mTOR-ATF4 axis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The cAMP/PKA/CREB and TGFβ/SMAD4 Pathways Regulate Stemness and Metastatic Potential in Colorectal Cancer Cells2022

Author(s)

Journal Title

DOI

Data Source

Kajino Rie 梶野リエ

KAJINO Rie 梶野リエ