Kajino Rie 梶野リエ

… Alternative Names

Researcher Number	20633184
Other IDs
Affiliation (Current)	2020: 愛知県がんセンター(研究所), がん病態生理学分野, 研究員
Affiliation (based on the past Project Information) *help	2018 – 2020: 愛知県がんセンター(研究所), がん病態生理学分野, 研究員 2017: 愛知県がんセンター(研究所), 分子病態学部｀, 研究員 2012 – 2016: 愛知県がんセンター(研究所), 分子病態学部, 研究員
Review Section/Research Field	Principal Investigator Tumor biology / Tumor biology / Basic Section 50010:Tumor biology-related Except Principal Investigator Tumor biology / Basic Section 50010:Tumor biology-related
Keywords	Principal Investigator 免疫学 / 大腸がん / 癌 / シグナル伝達 / 免疫 / 神経 / Apc変異 / 合成致死 / マウスモデル Except Principal Investigator 大腸がん … More

Apc変異腸管腫瘍におけるMyD88経路の役割解明と治療標的の探索Principal InvestigatorOngoing
- Principal Investigator
  
  梶野リエ
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Aichi Cancer Center Research Institute
Molecular mechanisms and preventive/therapeutic targets of colon cancer metastasisOngoing
- Principal Investigator
  
  青木正博
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Aichi Cancer Center Research Institute
Elucidating the mechanisms of colorectal cancer metastasis using mouse models
- Principal Investigator
  
  Aoki Masahiro
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Aichi Cancer Center Research Institute
Analysis of the role of nervous and immune system interactions in development of colon cancerPrincipal Investigator
- Principal Investigator
  
  Kajino Rie
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Aichi Cancer Center Research Institute
Analysis of the role of immune system in intestinal carcinogenesis and metastasis using a mouse modelPrincipal Investigator
- Principal Investigator
  
  KAJINO Rie
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Tumor biology
- Research Institution
  愛知県がんセンター(研究所)

All 2019 2018 2017 2016 2015 2014

All Journal Article Presentation

[Journal Article] Stromal Iodothyronine Deiodinase 2 (DIO2) Promotes the Growth of Intestinal Tumors in Apc Δ716 Mutant Mice2019
- Author(s)
  Kojima Yasushi、Kondo Yuriko、Fujishita Teruaki、Mishiro‐Sato Emi、Kajino‐Sakamoto Rie、Taketo Makoto Mark、Aoki Masahiro
- Journal Title
  
  Cancer Science
  
  Volume: 110 Pages: 2520-2528
- DOI
  10.1111/cas.14100
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02686, KAKENHI-PROJECT-17K07191
[Journal Article] Tumor microenvironment confers mTOR inhibitor resistance in invasive intestinal adenocarcinoma2017
- Author(s)
  Fujishita T, Kojima Y, Kajino-Sakamoto R, Taketo MM, Aoki M.
- Journal Title
  
  Oncogene
  
  Volume: 36 Pages: 6480-6489
- DOI
  10.1038/onc.2017.242
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07139, KAKENHI-PROJECT-26290045, KAKENHI-PLANNED-26111005
[Journal Article] Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC2017
- Author(s)
  Satoh K, Yachida S, Sugimoto M, Oshima M, Nakagawa T, Akamoto S, Tabata S, Saitoh K, Kato K, Sato S, Igarashi K, Aizawa Y, Kajino-Sakamoto R, Kojima Y, Fujishita T, Enomoto A, Hirayama A, Ishikawa T, Taketo MM, Kushida Y, Haba R, Okano K, Tomita M, Suzuki Y, Fukuda S, Aoki M, Soga T.
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America
  
  Volume: 114
- DOI
  10.1073/pnas.1710366114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07139, KAKENHI-PROJECT-16K21361, KAKENHI-PROJECT-26290045, KAKENHI-PUBLICLY-17H05654, KAKENHI-PLANNED-26111005, KAKENHI-PROJECT-26462860, KAKENHI-PROJECT-15K21364
[Journal Article] Antitumor activity of the MEK inhibitor trametinib on intestinal polyp formation in Apc(Δ716) mice involves stromal COX-2.2015
- Author(s)
  Fujishita T, Kajino-Sakamoto R, Kojima Y, Taketo MM, Aoki M.
- Journal Title
  
  Cancer Science
  
  Volume: 106 Pages: 692-699
- DOI
  10.1111/cas.12670
- NAID
  120005767023
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111005, KAKENHI-PROJECT-25253022, KAKENHI-PROJECT-26830090, KAKENHI-PROJECT-26290045
[Presentation] 腸管腫瘍形成におけるDio2(2 型脱ヨード酵素）の生物学的役割2019
- Author(s)
  小島　康、藤下晃章、梶野リエ、三城恵美、武藤　誠、青木正博
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02686
[Presentation] Synthetic lethality between Apc mutation and MyD88 loss in intestinal tumor epithelial cells2019
- Author(s)
  梶野リエ、藤下晃章、武藤誠、青木正博
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07254
[Presentation] MyD88 によるApc 変異腸上皮細胞の合成致死メカニズムの解明2019
- Author(s)
  梶野リエ、藤下晃章、武藤　誠、青木正博
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02686
[Presentation] Apc変異マウスの腸管腫瘍形成において腸上皮細胞のMyD88が果たす役割の解明2018
- Author(s)
  梶野リエ、藤下晃章、武藤誠、青木正博
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02686
[Presentation] Apc変異マウスの腸管腫瘍形成において腸上皮細胞のMyD88が果たす役割の解明2018
- Author(s)
  梶野リエ、藤下晃章、武藤誠、青木正博
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07254
[Presentation] Apc+/Δ716マウスの腸管腫瘍形成において腸上皮細胞のMyD88が果たす役割の解析2017
- Author(s)
  梶野リエ、藤下晃章、武藤誠、青木正博
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-26290045
[Presentation] 腸管腫瘍形成における JNK-mTORC1 経路活性化と神経伝達物質の関連の解明2016
- Author(s)
  梶野リエ、藤下晃章、武藤誠、青木正博
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Data Source
  KAKENHI-PROJECT-26290045
[Presentation] II型脱ヨード酵素の大腸がん進展における役割2016
- Author(s)
  小島康、今度ゆりこ、藤下晃章、梶野リエ、武藤誠、青木正博
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Data Source
  KAKENHI-PROJECT-26290045
[Presentation] がん微小環境は浸潤性腸がんのmTOR阻害薬抵抗性獲得に関与する2016
- Author(s)
  藤下晃章、梶野リエ、小島康、武藤誠、青木正博
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Data Source
  KAKENHI-PROJECT-26290045
[Presentation] 大腸がんマウスモデルとオルガノイド培養を用いた腫瘍形成における低酸素シグナルの役割の解明2016
- Author(s)
  梶野リエ、青木正博
- Organizer
  第14回がんとハイポキシア研究会
- Place of Presentation
  岐阜グランドホテル（岐阜県・岐阜市）
- Data Source
  KAKENHI-PROJECT-26290045
[Presentation] Analysis of the mechanisms of JNK-mTORC1 pathway activation during intestinal tumorigenesis2015
- Author(s)
  梶野リエ
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26830091
[Presentation] MEK/ERK経路の阻害はCOX2およびCCL2の発言レベルを減少させ腸管ポリープ形成を抑制する2015
- Author(s)
  藤下晃章、梶野リエ、小島康、武藤誠、青木正博
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県・名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26290045
[Presentation] 腸管腫瘍形成におけるJNK-mTORC1経路活性化機序の解析2015
- Author(s)
  梶野リエ、藤下晃章、小島康、武藤誠、青木正博
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県・名古屋市）
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-26290045
[Presentation] 腸管腫瘍形成における JNK-mTORC1 経路活性化機序の解析2014
- Author(s)
  梶野　リエ、藤下晃章、小島　康、武藤　誠、青木　正博
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2014-09-27
- Data Source
  KAKENHI-PROJECT-26290045
[Presentation] Apc+/Δ716マウスの腸管腫瘍におけるJNK-mTORC1経路活性化機序の解析2014
- Author(s)
  梶野　リエ、藤下晃章、小島　康、武藤　誠、青木　正博
- Organizer
  第37会日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2014-11-25
- Data Source
  KAKENHI-PROJECT-26290045
[Presentation] MEK阻害薬トラメチニブによる Apc 変異マウスの腸管ポリープ形成抑制効果2014
- Author(s)
  青木正博、梶野リエ、武藤誠、藤下晃章
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-26290045
[Presentation] 腸管腫瘍形成におけるJNK-mTORC１経路活性化機序の解析2014
- Author(s)
  梶野リエ
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2014-09-27
- Data Source
  KAKENHI-PROJECT-26830091
[Presentation] Apc+/Δ716マウスの腸管腫瘍におけるJNK-mTORC１経路活性化機序の解析2014
- Author(s)
  梶野リエ
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2014-11-25
- Data Source
  KAKENHI-PROJECT-26830091

1. Aoki Masahiro (60362464)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
2. 小島康 (30464217)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
3. 藤下晃章 (50511870)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
4. 佐久間圭一朗 (90402891)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TAKEDA Junji (50163407)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 三城恵美 (00455544)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. TABATA Sho

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. SUGIMOTO Masahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. HIRAYAMA Akiyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 福田真嗣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 武藤誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kajino Rie 梶野 リエ

KAJINO Rie 梶野 リエ

Research Projects

Research Products

Co-Researchers

Apc変異腸管腫瘍におけるMyD88経路の役割解明と治療標的の探索Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms and preventive/therapeutic targets of colon cancer metastasisOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating the mechanisms of colorectal cancer metastasis using mouse models

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the role of nervous and immune system interactions in development of colon cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the role of immune system in intestinal carcinogenesis and metastasis using a mouse modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Stromal Iodothyronine Deiodinase 2 (DIO2) Promotes the Growth of Intestinal Tumors in Apc Δ716 Mutant Mice2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tumor microenvironment confers mTOR inhibitor resistance in invasive intestinal adenocarcinoma2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antitumor activity of the MEK inhibitor trametinib on intestinal polyp formation in Apc(Δ716) mice involves stromal COX-2.2015

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] 腸管腫瘍形成におけるDio2(2 型脱ヨード酵素）の生物学的役割2019

Author(s)

Organizer

Data Source

[Presentation] Synthetic lethality between Apc mutation and MyD88 loss in intestinal tumor epithelial cells2019

Author(s)

Organizer

Data Source

[Presentation] MyD88 によるApc 変異腸上皮細胞の合成致死メカニズムの解明2019

Author(s)

Organizer

Data Source

[Presentation] Apc変異マウスの腸管腫瘍形成において腸上皮細胞のMyD88が果たす役割の解明2018

Author(s)

Organizer

Data Source

[Presentation] Apc変異マウスの腸管腫瘍形成において腸上皮細胞のMyD88が果たす役割の解明2018

Author(s)

Organizer

Data Source

[Presentation] Apc+/Δ716マウスの腸管腫瘍形成において腸上皮細胞のMyD88が果たす役割の解析2017

Author(s)

Organizer

Data Source

Kajino Rie 梶野リエ

KAJINO Rie 梶野リエ

[Presentation] 大腸がんマウスモデルとオルガノイド培養を用いた腫瘍形成における低酸素シグナルの役割の解明2016