KOJIMA Yasushi 小島康

Researcher Number	30464217
Other IDs
Affiliation (Current)	2021: 愛知県がんセンター(研究所), がん病態生理学分野, 主任研究員
Affiliation (based on the past Project Information) *help	2021: 愛知県がんセンター(研究所), その他部局等, 研究員 2018 – 2020: 愛知県がんセンター(研究所), がん病態生理学分野, 主任研究員 2011 – 2017: 愛知県がんセンター(研究所), 分子病態学部, 主任研究員 2013: 愛知県がんセンター(研究所), 分子病態学部, 主任研究員
Review Section/Research Field	Principal Investigator Tumor biology / Tumor biology / Basic Section 50010:Tumor biology-related Except Principal Investigator Tumor biology / Tumor biology / Basic Section 50010:Tumor biology-related
Keywords	Principal Investigator 大腸がん / 核膜孔複合体 / 核ラミナ / 腫瘍生物学 / 大腸癌 / Wnt / 実験動物 / 甲状腺 / DIO2 / 大腸 / 腫瘍血管 / 遺伝子改変動物 / がん微小環境 … More Except Principal Investigator … More

臨床応用を指向したがん悪液質病態解明Principal InvestigatorOngoing
- Principal Investigator
  
  小島康
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Aichi Cancer Center Research Institute
Molecular mechanisms and preventive/therapeutic targets of colon cancer metastasisOngoing
- Principal Investigator
  
  青木正博
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Aichi Cancer Center Research Institute
Roles of Dio2 (deiodinase, iodothyronine, type II) in colorectal tumorigenesisPrincipal Investigator
- Principal Investigator
  
  Kojima Yasushi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Aichi Cancer Center Research Institute
Generation of a genetically engineered mouse model that reproducibly develops tumors in the large intestinePrincipal Investigator
- Principal Investigator
  
  Kojima Yasushi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor biology
- Research Institution
  Aichi Cancer Center Research Institute
Elucidating the mechanisms of colorectal cancer metastasis using mouse models
- Principal Investigator
  
  Aoki Masahiro
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Aichi Cancer Center Research Institute
Development of in vivo screening systems for cancer metastasis suppressors
- Principal Investigator
  
  AOKI MASAHIRO
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor biology
- Research Institution
  愛知県がんセンター(研究所)
Roles of nuclear pore complex and lamina in intestinal tumor formationPrincipal Investigator
- Principal Investigator
  
  KOJIMA Yasushi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Tumor biology
- Research Institution
  Aichi Cancer Center Research Institute

All 2019 2018 2017 2016 2015 2014 2013

All Journal Article Presentation

[Journal Article] Stromal Iodothyronine Deiodinase 2 (DIO2) Promotes the Growth of Intestinal Tumors in Apc Δ716 Mutant Mice2019
- Author(s)
  Kojima Yasushi、Kondo Yuriko、Fujishita Teruaki、Mishiro‐Sato Emi、Kajino‐Sakamoto Rie、Taketo Makoto Mark、Aoki Masahiro
- Journal Title
  
  Cancer Science
  
  Volume: 110 Pages: 2520-2528
- DOI
  10.1111/cas.14100
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02686, KAKENHI-PROJECT-17K07191
[Journal Article] Tumor microenvironment confers mTOR inhibitor resistance in invasive intestinal adenocarcinoma2017
- Author(s)
  Fujishita T, Kojima Y, Kajino-Sakamoto R, Taketo MM, Aoki M.
- Journal Title
  
  Oncogene
  
  Volume: 36 Pages: 6480-6489
- DOI
  10.1038/onc.2017.242
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07139, KAKENHI-PROJECT-26290045, KAKENHI-PLANNED-26111005
[Journal Article] Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC2017
- Author(s)
  Satoh K, Yachida S, Sugimoto M, Oshima M, Nakagawa T, Akamoto S, Tabata S, Saitoh K, Kato K, Sato S, Igarashi K, Aizawa Y, Kajino-Sakamoto R, Kojima Y, Fujishita T, Enomoto A, Hirayama A, Ishikawa T, Taketo MM, Kushida Y, Haba R, Okano K, Tomita M, Suzuki Y, Fukuda S, Aoki M, Soga T.
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America
  
  Volume: 114
- DOI
  10.1073/pnas.1710366114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07139, KAKENHI-PROJECT-16K21361, KAKENHI-PROJECT-26290045, KAKENHI-PUBLICLY-17H05654, KAKENHI-PLANNED-26111005, KAKENHI-PROJECT-26462860, KAKENHI-PROJECT-15K21364
[Journal Article] Association between ABCG2 and SLCO1B1 polymorphisms and adverse drug reactions to regorafenib.2017
- Author(s)
  Maeda A, Ando H, Ura T, Komori A, Hasegawa A, Taniguchi H, Kadowaki S, Muro K, Tajika M, Kobara M, Matsuzaki M, Hashimoto N, Maeda M, Kojima Y, Aoki M, Kondo E, Mizutani A, Fujimura A.
- Journal Title
  
  Journal of Clinical Pharmacology and Therapeutics
  
  Volume: epub ahead of print Pages: 409-415
- DOI
  10.5414/cp202788
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26111005, KAKENHI-PROJECT-26290045, KAKENHI-PROJECT-16K15245
[Journal Article] Antitumor activity of the MEK inhibitor trametinib on intestinal polyp formation in Apc(Δ716) mice involves stromal COX-2.2015
- Author(s)
  Fujishita T, Kajino-Sakamoto R, Kojima Y, Taketo MM, Aoki M.
- Journal Title
  
  Cancer Science
  
  Volume: 106 Pages: 692-699
- DOI
  10.1111/cas.12670
- NAID
  120005767023
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111005, KAKENHI-PROJECT-25253022, KAKENHI-PROJECT-26830090, KAKENHI-PROJECT-26290045
[Presentation] 腸管腫瘍形成におけるDio2（２型脱ヨード酵素）の生物学的役割2019
- Author(s)
  小島　康
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07191
[Presentation] cis-Apc/Smad4 マウスのMEK 阻害薬抵抗性腸管腺がんにおけるInpp5f タンパクの発現低下2019
- Author(s)
  藤下晃章、三城恵美、小島　康、武藤　誠、青木正博
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02686
[Presentation] 腸管腫瘍形成におけるDio2(2 型脱ヨード酵素）の生物学的役割2019
- Author(s)
  小島　康、藤下晃章、梶野リエ、三城恵美、武藤　誠、青木正博
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02686
[Presentation] Apc変異マウスの腸管腫瘍形成におけるMyD88の役割の解析2018
- Author(s)
  青木正博、小島康、曽我朋義
- Organizer
  第22回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02686
[Presentation] 大腸がん形成におけるDio2の役割2018
- Author(s)
  小島康
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02686
[Presentation] Role of Dio2 (deiodinase, Iodothyronine, Type II) in colon tumorigenesis.2018
- Author(s)
  Kojima, Y., Fujishita T., Mishiro E., Kajino R., Taketo, M.M. & Aoki M.
- Organizer
  The 77th Annual Meeting of the Japanese Cancer Association, Osaka
- Data Source
  KAKENHI-PROJECT-17K07191
[Presentation] がん悪液質マウスモデルにおける全身的代謝異常2017
- Author(s)
  青木正博、小島康、曽我朋義
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-26290045
[Presentation] エルロチニブとトラメチニブの併用投与はcis-Apc/Smad4マウスの腸管腺がん形成を抑制する2017
- Author(s)
  津田都子、藤下晃章、小島康、武藤誠、青木正博
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-26290045
[Presentation] 腸管腫瘍の薬剤抵抗性獲得におけるEGF受容体の役割2017
- Author(s)
  藤下晃章，津田都子、小島康、武藤誠、青木正博
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-26290045
[Presentation] 新規がん悪液質マウスモデルの表現型解析2017
- Author(s)
  小島康、曽我朋義、武藤誠、青木正博
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-26290045
[Presentation] がん悪液質の代謝異常2017
- Author(s)
  青木正博、小島康、曽我朋義
- Organizer
  第5回がんと代謝研究会
- Data Source
  KAKENHI-PROJECT-26290045
[Presentation] II型脱ヨード酵素の大腸がん進展における役割2016
- Author(s)
  小島康、今度ゆりこ、藤下晃章、梶野リエ、武藤誠、青木正博
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Data Source
  KAKENHI-PROJECT-26290045
[Presentation] がん微小環境は浸潤性腸がんのmTOR阻害薬抵抗性獲得に関与する2016
- Author(s)
  藤下晃章、梶野リエ、小島康、武藤誠、青木正博
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Data Source
  KAKENHI-PROJECT-26290045
[Presentation] MEK/ERK経路の阻害はCOX2およびCCL2の発言レベルを減少させ腸管ポリープ形成を抑制する2015
- Author(s)
  藤下晃章、梶野リエ、小島康、武藤誠、青木正博
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県・名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26290045
[Presentation] 腸管腫瘍形成におけるJNK-mTORC1経路活性化機序の解析2015
- Author(s)
  梶野リエ、藤下晃章、小島康、武藤誠、青木正博
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県・名古屋市）
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-26290045
[Presentation] II型脱ヨード酵素の大腸がん進展における役割の検討2015
- Author(s)
  小島康、藤下晃章、武藤誠、青木正博
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県・名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26290045
[Presentation] 腸管腫瘍形成における甲状腺ホルモンの役割2015
- Author(s)
  小島康、オリム・フローレンス、藤下晃章、武藤誠、青木正博
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26290045
[Presentation] Apc+/Δ716マウスの腸管腫瘍におけるJNK-mTORC1経路活性化機序の解析2014
- Author(s)
  梶野　リエ、藤下晃章、小島　康、武藤　誠、青木　正博
- Organizer
  第37会日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2014-11-25
- Data Source
  KAKENHI-PROJECT-26290045
[Presentation] 腸管腫瘍形成における JNK-mTORC1 経路活性化機序の解析2014
- Author(s)
  梶野　リエ、藤下晃章、小島　康、武藤　誠、青木　正博
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2014-09-27
- Data Source
  KAKENHI-PROJECT-26290045
[Presentation] 日本人胃がん患者の体組成変化2013
- Author(s)
  小島康、松尾恵太郎、伊藤秀美、細野覚代、田中英夫、青木正博
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2013-10-05
- Data Source
  KAKENHI-PROJECT-24650627

1. SAKUMA Keiichiro (90402891)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. AOKI MASAHIRO (60362464)

# of Collaborated Projects: 3 results

# of Collaborated Products: 22 results
3. 梶野リエ (20633184)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
4. 藤下晃章 (50511870)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
5. TAKEDA Junji (50163407)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. ORIM FLORENCE (90750810)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 三城恵美 (00455544)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. TABATA Sho

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. SUGIMOTO Masahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. HIRAYAMA Akiyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. KONDO Eisaku

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 武藤誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 福田真嗣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KOJIMA Yasushi 小島 康

Research Projects

Research Products

Co-Researchers

臨床応用を指向したがん悪液質病態解明Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms and preventive/therapeutic targets of colon cancer metastasisOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Roles of Dio2 (deiodinase, iodothyronine, type II) in colorectal tumorigenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Generation of a genetically engineered mouse model that reproducibly develops tumors in the large intestinePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidating the mechanisms of colorectal cancer metastasis using mouse models

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of in vivo screening systems for cancer metastasis suppressors

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of nuclear pore complex and lamina in intestinal tumor formationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Stromal Iodothyronine Deiodinase 2 (DIO2) Promotes the Growth of Intestinal Tumors in Apc Δ716 Mutant Mice2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tumor microenvironment confers mTOR inhibitor resistance in invasive intestinal adenocarcinoma2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association between ABCG2 and SLCO1B1 polymorphisms and adverse drug reactions to regorafenib.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antitumor activity of the MEK inhibitor trametinib on intestinal polyp formation in Apc(Δ716) mice involves stromal COX-2.2015

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] 腸管腫瘍形成におけるDio2（２型脱ヨード酵素）の生物学的役割2019

Author(s)

Organizer

Data Source

[Presentation] cis-Apc/Smad4 マウスのMEK 阻害薬抵抗性腸管腺がんにおけるInpp5f タンパクの発現低下2019

Author(s)

Organizer

Data Source

KOJIMA Yasushi 小島康