MUROI Makoto 室井誠

… Alternative Names

室井誠ムロイマコト

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Researcher Number	30261168
Other IDs
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 環境資源科学研究センター, 上級研究員
Affiliation (based on the past Project Information) *help	2018 – 2024: 国立研究開発法人理化学研究所, 環境資源科学研究センター, 専任研究員 2017: 国立研究開発法人理化学研究所, 環境資源科学研究センター, 先任研究員 2016: 理化学研究所, 環境資源科学研究センターケミカルバイオロジー研究グループ, 専任研究員 2014: 独立行政法人理化学研究所, 環境資源科学研究センター, 上級研究員 2013: 独立行政法人理化学研究所, 長田抗生物質研究室, 専任研究員 … More 2012: 独立行政法人理化学研究所, 化合物ライブラリー評価研究チーム, 専任研究員 2009: The Institute of Physical and Chemical Research, 化合物ライブラリー評価研究チーム, 先任研究員 2004 – 2008: 独立行政法人理化学研究所, 長田抗生物質研究室, 先任研究員 1999 – 2000: 理化学研究所, 動物・細胞システム研究室, 研究員 1995: 理化学研究所, 動物・細胞システム研究室, 研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 38040:Bioorganic chemistry-related / 応用微生物学・応用生物化学 / Bioorganic chemistry / Science and Engineering / Bioproduction chemistry/Bioorganic chemistry Except Principal Investigator Medium-sized Section 38:Agricultural chemistry and related fields / Science and Engineering / Biomolecular chemistry / Applied biochemistry / Bioproduction chemistry/Bioorganic chemistry / Living organism molecular science / Biological Sciences
Keywords	Principal Investigator 阻害剤 / プロテオミクス / ケミカルバイオロジー / プロテオーム / 生理活性物質 / 標的分子同定 / プロファイリング / 標的同定 / 標的分子 / proteome analysis … More / 細胞内転送 / 糖蛋白質 / inhibitor / targget identification / chemical biology / 相互作用 / 分子標的 / chemicalbiology / drug target / proteome / インフォマティクス / 代謝 / 天然物 / ChemProteoBase / 作用解析 / クラスター解析 / HeLa細胞 / プロテオーム解析 / target Protein / 2D-DIGE / target protein / small molecule / proteomic analysis / Cryptotanshinone / Dihydrotanshinone I / ゴルジ / ミコフェノール酸 / スフィンゴミエリン / グルコシルセラミド / スフィンゴ脂質 / Destruxin / Bafilomycin / Concanamycin / 液胞型ATPase … More Except Principal Investigator ケミカルバイオロジー / プロテオーム / 人工知能 / 抗真菌剤 / フェアリーリング / 植物ホルモン / フェアリー化合物 / プロテオーム解析 / 2D-DIEG / HSP-90 / 標的同定 / Hsp-90 / 神経保護作用 / ゲルダナマイシン / Single allele / Tubulin / Yeast / ピロネチン / タキソール / 単一アリル / チューブリン / 酵母 / NPPlot / ChemProteoBase / MPPlot / データベース / フラクションライブラリー / 微生物代謝産物 / 生物活性物質 / エンドサイトーシス / 小分子化合物 / 癌 / 金属依存性マトリックス分解酵素 / アポトーシス / 破骨細胞 / がん細胞 / V-ATPase / イエジマライド / 骨転移 / リベロマイシンA / ビオチン / VEGF / 血管内皮細胞 / Epoxyquinol B / 放線菌 / GLO1 / メチルゲルフィリン / 2D-DIGE / リベロマイシン / p38 / 生合成遺伝子 / プロテオミクス / フミトレモルジン / 天然化合物 / 血管新生 / 癌転移 Less

MSベースのプロテオームプロファイリングに基づく薬剤標的解析システムの構築Principal Investigator
- Principal Investigator
  
  室井誠
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Institute of Physical and Chemical Research
Exploration of antifungals based on AI-based screening systems
- Principal Investigator
  
  Osada Hiroyuki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  Institute of Physical and Chemical Research
プロテオーム解析を用いた直接的アプローチ法による薬剤標的同定解析システムの開発Principal Investigator
- Principal Investigator
  
  室井誠
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Institute of Physical and Chemical Research
Science of fairy chemicals and their application development
- Principal Investigator
  
  河岸洋和
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Science and Engineering
- Research Institution
  Shizuoka University
Development of compound evaluation system based on pathway analysis using proteome analysisPrincipal Investigator
- Principal Investigator
  
  Muroi Makoto
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Institute of Physical and Chemical Research
Molecular mechanism of neuroprotective activity of geldanamycin
- Principal Investigator
  
  NISHIKAWA Toshio
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Nagoya University
薬剤標的同定の為のプロテオミクス的プロファイリング法の改良と利用Principal Investigator
- Principal Investigator
  
  室井誠
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  The Institute of Physical and Chemical Research
Construction of the database of microbial products and its application study
- Principal Investigator
  
  OSADA Hiroyuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  The Institute of Physical and Chemical Research
Development of anti-cancer agents targeting the endocytic pathway
- Principal Investigator
  
  KAWATANI Makoto
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Living organism molecular science
- Research Institution
  The Institute of Physical and Chemical Research
プロテオミックス的手法を用いた薬剤作用解析システムの構築Principal Investigator
- Principal Investigator
  
  室井誠
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  The Institute of Physical and Chemical Research
Drug discovery research based on the molecular mechanisms of tumor growth and metastasis
- Principal Investigator
  
  OSADA Hiroyuki
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
Analysis of interaction between microtubule-associated protein/microtubule-targeting agents and single allele tubulin.
- Principal Investigator
  
  USUI Takeo
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied biochemistry
- Research Institution
  University of Tsukuba
  The Institute of Physical and Chemical Research
選択的阻害剤を用いたスフィンゴ脂質の合成と細胞内転送過程の解析Principal Investigator
- Principal Investigator
  
  室井誠
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  The Institute of Physical and Chemical Research
選択的阻害剤の作用特性の違いを利用した液砲型ATPaseの構造と機能の解析Principal Investigator
- Principal Investigator
  
  室井誠
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  The Institute of Physical and Chemical Research

[Book] 医薬品開発におけるオミクス解析技術～ゲノム・トランスクリプトーム・プロテオーム・メタボローム～2020
- Author(s)
  鎌田　真由美, 奥野　恭史, 山田　弘, 森田　英利, 田丸　浩, 伊藤　昌可, 林崎　良英, 飯塚　朋代, 小林　巧, 池尾　一穂, 中岡　慎治, 松田　史生, 室井　誠, 小川　直子, 長田　裕之, 三浦　信明, 杉本　昌弘, 中山　泰宗, 三枝　淳, 松本　光晴, 久保田　浩行, 金井　弥栄, 津田　昇, 鈴木　孝昌
- Total Pages
  181
- Publisher
  情報機構
- ISBN
  9784865021844
- Data Source
  KAKENHI-PROJECT-17K07783
[Journal Article] 3,6-Epidioxy-1,10-bisaboladiene induces ferroptosis-like cell death through lipid peroxidation2023
- Author(s)
  Usukhbayar Narandulam、Takano Yukie、Uesugi Shota、Muroi Makoto、Osada Hiroyuki、Kimura Ken-ichi
- Journal Title
  
  Free Radical Research
  
  Volume: 57 Issue: 3 Pages: 208-222
- DOI
  10.1080/10715762.2023.2229005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05857, KAKENHI-PROJECT-23K02000, KAKENHI-PROJECT-22H04922
[Journal Article] Identification of a dihydroorotate dehydrogenase inhibitor that inhibits cancer cell growth by proteomic profiling2023
- Author(s)
  KAWATANI MAKOTO、AONO HARUMI、HIRANUMA SAYOKO、SHIMIZU TAKESHI、MUROI MAKOTO、NOGAWA TOSHIHIKO、OHISHI TOMOKAZU、OHBA SHUN-ICHI、KAWADA MANABU、YAMAZAKI KANAMI、DAN SHINGO、DOHMAE NAOSHI、OSADA HIROYUKI
- Journal Title
  
  Oncology Research
  
  Volume: 31 Issue: 6 Pages: 833-844
- DOI
  10.32604/or.2023.030241
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K05857, KAKENHI-PROJECT-22K05363, KAKENHI-PROJECT-22K06783, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21H04720
[Journal Article] Isolation of novel chemical components and their plant target proteins under selenium stress2023
- Author(s)
  Moon Ju Yeon、Miyazaki Takae、Muroi Makoto、Watanabe Nobomoto、Shin Ryoung
- Journal Title
  
  Methods Enzymol
  
  Volume: 680 Pages: 421-438
- DOI
  10.1016/bs.mie.2022.07.035
- ISBN
  9780443185847
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05857, KAKENHI-PROJECT-22H04922
[Journal Article] Allantopyrone A interferes with the degradation of hypoxia-inducible factor 1α protein by reducing proteasome activity in human fibrosarcoma HT-1080 cells.2023
- Author(s)
  Okuda C, Ueda Y, Muroi M, Sanada E, Osada H, Shiono Y, Kimura KI, Takeda K, Kawaguchi K, Kataoka T
- Journal Title
  
  J Antibiot
  
  Volume: - Issue: 6 Pages: 324-334
- DOI
  10.1038/s41429-023-00610-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05857, KAKENHI-PROJECT-22H04922
[Journal Article] Two-dimensional electrophoresis-cellular thermal shift assay (2DE-CETSA) for target identification of bioactive compounds.2022
- Author(s)
  Muroi M, Osada H
- Journal Title
  
  Methods Enzymol
  
  Volume: 675 Pages: 425-437
- DOI
  10.1016/bs.mie.2022.07.018
- ISBN
  9780323992664
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05857, KAKENHI-PROJECT-21H04720, KAKENHI-PLANNED-17H06412
[Journal Article] Isoquercitrin from <i>Apocynum venetum</i> L. produces an anti-obesity effect on obese mice by targeting C-1-tetrahydrofolate synthase, carbonyl reductase, and glutathione S-transferase P and modification of the AMPK/SREBP-1c/FAS/CD36 signaling pathway in mice <i>in vivo</i>.2022
- Author(s)
  Manzoor M, Muroi M, Ogawa N, Kobayashi H, Nishimura H, Chen D, Fasina OB, Wang J, Osada H, Yoshida M, Xiang L, Qi J
- Journal Title
  
  Food Funct
  
  Volume: 13 Issue: 21 Pages: 10923-10936
- DOI
  10.1039/d2fo02438a
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K05857, KAKENHI-PLANNED-18H05503, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-19H05640
[Journal Article] Identification of a small molecule that enhances ferroptosis via inhibition of FSP1.2022
- Author(s)
  Yoshioka H, Kawamura T, Muroi M, Kondoh Y, Honda K, Kawatani M, Aono H, Waldmann H, Watanabe N, Osada H.
- Journal Title
  
  ACS Chemical Biology
  
  Volume: 17 Issue: 2 Pages: 483-491
- DOI
  10.1021/acschembio.2c00028
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-19K05744, KAKENHI-PROJECT-20K05857, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21H04720, KAKENHI-PUBLICLY-21H00295, KAKENHI-PLANNED-17H06412
[Journal Article] Identification of Dihydroorotate Dehydrogenase Inhibitors─Indoluidins─That Inhibit Cancer Cell Growth2021
- Author(s)
  Kawatani Makoto、Aono Harumi、Shimizu Takeshi、Ohkura Shouta、Hiranuma Sayoko、Muroi Makoto、Ogawa Naoko、Ohishi Tomokazu、Ohba Shun-ichi、Kawada Manabu、Yamazaki Kanami、Dan Shingo、Osada Hiroyuki
- Journal Title
  
  ACS Chemical Biology
  
  Volume: 16 Issue: 11 Pages: 2570-2580
- DOI
  10.1021/acschembio.1c00625
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05744, KAKENHI-PROJECT-20K05857, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-21H04720, KAKENHI-PLANNED-17H06412
[Journal Article] Identification of a Small-Molecule Glucose Transporter Inhibitor, Glutipyran, That Inhibits Cancer Cell Growth2021
- Author(s)
  Kawatani Makoto、Aono Harumi、Hiranuma Sayoko、Shimizu Takeshi、Muroi Makoto、Ogawa Naoko、Ohishi Tomokazu、Ohba Shun-ichi、Kawada Manabu、Nogawa Toshihiko、Okano Akiko、Hashizume Daisuke、Osada Hiroyuki
- Journal Title
  
  ACS Chemical Biology
  
  Volume: 16 Issue: 8 Pages: 1576-1586
- DOI
  10.1021/acschembio.1c00480
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05744, KAKENHI-PROJECT-20K05857, KAKENHI-PROJECT-20K05858, KAKENHI-PROJECT-16H06276, KAKENHI-PLANNED-17H06412
[Journal Article] A cesium tolerance-enhancing chemical promotes cesium tolerance in Arabidopsis thaliana by interacting with BETA-GLUCOSIDASE 23.2021
- Author(s)
  Moon JY, Adams E, Miyazaki T, Kondoh Y, Muroi M, Watanabe N, Osada H, Shin R
- Journal Title
  
  Scientific Reports
  
  Volume: 26 Issue: 1 Pages: 21109-21109
- DOI
  10.1038/s41598-021-00564-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-20K05857, KAKENHI-PLANNED-17H06412, KAKENHI-PUBLICLY-21H00295
[Journal Article] Proteomics-based target identification of natural products affecting cancer metabolism.2021
- Author(s)
  Muroi M, Osada H.
- Journal Title
  
  J Antibiot
  
  Volume: 74 Issue: 10 Pages: 639-650
- DOI
  10.1038/s41429-021-00437-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05857, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-21H04720, KAKENHI-PLANNED-17H06412
[Journal Article] Interaction between goniothalamin and peroxisomal multifunctional enzyme type 2 triggering endoplasmic reticulum stress2020
- Author(s)
  Sophonnithiparasert T, Aruksakunwong O, Tashiro E, Kondoh Y, Muroi M, Osada H, Imoto M, Watanapokasin R
- Journal Title
  
  Heliyon
  
  Volume: 6 Issue: 10 Pages: e05200-e05200
- DOI
  10.1016/j.heliyon.2020.e05200
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K05732, KAKENHI-PROJECT-20K05857, KAKENHI-PLANNED-17H06412, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-18K05366
[Journal Article] Identification of Target Protein for Bio-active Small Molecule Using Photo-cross Linked Beads and MALDI-TOF Mass Spectrometry2020
- Author(s)
  Suvarna Kruthi、Honda Kaori、Muroi Makoto、Kondoh Yasumitsu、Watanabe Nobumoto、Osada Hiroyuki
- Journal Title
  
  BIO-PROTOCOL
  
  Volume: 10 Issue: 3
- DOI
  10.21769/bioprotoc.3517
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05366, KAKENHI-PLANNED-17H06412, KAKENHI-PLANNED-18H05503, KAKENHI-PUBLICLY-19H05302, KAKENHI-PROJECT-17K07783
[Journal Article] Measurement of ATPase Activity of Valosin-containing Protein/p972020
- Author(s)
  Suvarna Kruthi、Honda Kaori、Muroi Makoto、Kondoh Yasumitsu、Osada Hiroyuki、Watanabe Nobumoto
- Journal Title
  
  BIO-PROTOCOL
  
  Volume: 10 Issue: 3
- DOI
  10.21769/bioprotoc.3516
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05366, KAKENHI-PLANNED-17H06412, KAKENHI-PLANNED-18H05503, KAKENHI-PUBLICLY-19H05302, KAKENHI-PROJECT-17K07783
[Journal Article] Inhibition of mitochondrial complex I by the novel compound FSL0260 enhances high salinity-stress tolerance in Arabidopsis thaliana2020
- Author(s)
  Sako Kaori、Futamura Yushi、Shimizu Takeshi、Matsui Akihiro、Hirano Hiroyuki、Kondoh Yasumitsu、Muroi Makoto、Aono Harumi、Tanaka Maho、Honda Kaori、Shimizu Kenshirou、Kawatani Makoto、Nakano Takeshi、Osada Hiroyuki、Noguchi Ko、Seki Motoaki
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 8691-8691
- DOI
  10.1038/s41598-020-65614-9
- NAID
  120006876594
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01970, KAKENHI-PROJECT-19K05744, KAKENHI-PROJECT-20K05857, KAKENHI-PROJECT-18K14441, KAKENHI-PLANNED-17H06412, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-18H02140, KAKENHI-PROJECT-18K05366
[Journal Article] Discovery of small-molecule modulator of heterotrimeric Gi-protein by integrated phenotypic profiling and chemical proteomics2020
- Author(s)
  16)Kawamura, T., Futamura, Y., Shang, E., Muroi, M., Janning, P., Ueno, M., Wilke, J., Takeda, S., Kondoh, Y., Ziegler, S., Watanabe, N., Waldmann, H., Osada, H.
- Journal Title
  
  Biosci. Biotechnol. Biochem.
  
  Volume: 84 Issue: 12 Pages: 2484-2490
- DOI
  10.1080/09168451.2020.1812375
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K05857, KAKENHI-PLANNED-17H06412, KAKENHI-PLANNED-18H05503, KAKENHI-PUBLICLY-19H05302, KAKENHI-PROJECT-18K05366
[Journal Article] Miclxin, a novel MIC60 inhibitor, induces apoptosis via mitochondrial stress in β-catenin mutant tumor cells.2020
- Author(s)
  20)Ikeda, H., Muroi, M., Kondoh, Y., Ishikawa, S., Kakeya, H., Osada, H., Imoto, M.
- Journal Title
  
  ACS Chem. Biol.
  
  Volume: 15 Issue: 8 Pages: 2195-2204
- DOI
  10.1021/acschembio.0c00381
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K05857, KAKENHI-PLANNED-17H06401, KAKENHI-PLANNED-17H06412, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-18H02099, KAKENHI-PROJECT-18K05366, KAKENHI-PROJECT-16H06276
[Journal Article] Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA2020
- Author(s)
  Nagasawa Ikuko、Muroi Makoto、Kawatani Makoto、Ohishi Tomokazu、Ohba Shun-ichi、Kawada Manabu、Osada Hiroyuki
- Journal Title
  
  Cell Chemical Biology
  
  Volume: 27 Issue: 2 Pages: 1-11
- DOI
  10.1016/j.chembiol.2019.11.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08693, KAKENHI-PROJECT-19K05744, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-17K07783, KAKENHI-PROJECT-19K15717, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20K05857
[Journal Article] Structure characterization and action mechanism of an antiaging new compound from Gastrodia elata Blume.2019
- Author(s)
  Farooq U, Pan Y, Lin Y, Wang Y, Osada H, Xiang L, Qi J.
- Journal Title
  
  Oxid Med Cell Longev
  
  Volume: 2019 Pages: 5459862-5459862
- DOI
  10.1155/2019/5459862
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-17K07783
[Journal Article] 3β,23,28-Trihydroxy-12-oleanene 3β-caffeate from Desmodium sambuense-induced neurogenesis in PC12 cells mediated by ER stress and BDNF-TrkB signaling pathways.2019
- Author(s)
  Cheng L, Muroi M, Cao S, Bian L, Osada H, Xiang L, Qi J
- Journal Title
  
  Mol Pharm
  
  Volume: 16 Issue: 4 Pages: 1423-1432
- DOI
  10.1021/acs.molpharmaceut.8b00939
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07783, KAKENHI-PLANNED-17H06412
[Journal Article] A novel inhibitor of tumorspheres reveals the activation of the serine biosynthetic pathway upon mitochondrial inhibition.2019
- Author(s)
  Subedi A, Muroi M, Futamura Y, Kawamura T, Aono H, Nishi M, Ryo A, Watanabe N, Osada H.
- Journal Title
  
  FEBS Lett.
  
  Volume: 593 Issue: 8 Pages: 763-776
- DOI
  10.1002/1873-3468.13361
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01970, KAKENHI-PROJECT-17K07783, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-18H03945, KAKENHI-PROJECT-18K09000, KAKENHI-PUBLICLY-19H05302
[Journal Article] A small-molecule ligand of valosin-containing protein/p97 inhibits cancer cell-accelerated fibroblast migration.2019
- Author(s)
  Suvarna K, Honda K, Muroi M, Kondoh Y, Osada H, Watanabe N
- Journal Title
  
  J Biol Chem
  
  Volume: 294 Issue: 9 Pages: 2988-2996
- DOI
  10.1074/jbc.ra118.004741
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07783, KAKENHI-PROJECT-18K05366, KAKENHI-PLANNED-17H06412, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-18H03945
[Journal Article] Bioenergetic and proteomic profiling to screen small molecule inhibitors that target cancer metabolisms.2019
- Author(s)
  Futamura Y, Muroi M, Aono H, Kawatani M, Hayashida M, Sekine T, Nogawa T, Osada H.
- Journal Title
  
  Biochim Biophys Acta Proteins Proteom.
  
  Volume: 1867 Issue: 1 Pages: 28-37
- DOI
  10.1016/j.bbapap.2018.06.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01970, KAKENHI-PROJECT-17K07783, KAKENHI-PROJECT-17K07784, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-18H03945, KAKENHI-PROJECT-16K01941
[Journal Article] Proteomic profiling for target identification of biologically active small molecules using 2D DIGE.2018
- Author(s)
  Muroi M, Osada H.
- Journal Title
  
  Systems Chemical Biology (Ziegler S. and Waldmann H. eds.): Methods and Protocols, Methods in Molecular Biology
  
  Volume: 1888 Pages: 127-139
- DOI
  10.1007/978-1-4939-8891-4_7
- ISBN
  9781493988907, 9781493988914
- Data Source
  KAKENHI-PROJECT-17K07783
[Journal Article] Phenotypic identification of a novel autophagy inhibitor chemotype targeting lipid kinase VPS342017
- Author(s)
  Robke L, Laraia L, Carnero Corrales MA, Konstantinidis G, Muroi M, Richters A, Winzker M, Engbring T, Tomassi S, Watanabe N, Osada H, Rauh D, Waldmann H, Wu YW, Engel J
- Journal Title
  
  Angew Chem Int Ed Engl
  
  Volume: 56 Issue: 28 Pages: 8153-8157
- DOI
  10.1002/anie.201703738
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07783, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-16H06276
[Journal Article] Development of a terpenoid-production platform in Streptomyces reveromyceticus SN-5932017
- Author(s)
  Khalid A、Takagi H、Panthee S、Muroi M、Chappell J、Osada H、Takahashi S
- Journal Title
  
  ACS Synthetic Biology
  
  Volume: 6 Issue: 12 Pages: 2339-2349
- DOI
  10.1021/acssynbio.7b00249
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07783, KAKENHI-PUBLICLY-17H05455, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-16H04905, KAKENHI-PROJECT-16H06276
[Journal Article] Allantopyrone A activates the Keap1-Nrf2 pathway and protects from oxidative stress-induced cell death in PC12 cells2017
- Author(s)
  Shota Uesugi, Makoto Muroi, Yasumitsu Kondoh, Yoshihito Shiono, Hiroyuki Osada, Ken-ichi Kimura
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 70 Issue: 4 Pages: 429-434
- DOI
  10.1038/ja.2016.99
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15J04501, KAKENHI-PROJECT-26350976, KAKENHI-PROJECT-17K07783, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-16H04910, KAKENHI-PROJECT-16H06276
[Journal Article] A small molecule that induces reactive oxygen species via cellular glutathione depletion.2014
- Author(s)
  Kawamura T, Kondoh Y, Muroi M, Kawatani M, Osada H.
- Journal Title
  
  Biochem J
  
  Volume: 463 Issue: 1 Pages: 53-63
- DOI
  10.1042/bj20140669
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24248022, KAKENHI-PROJECT-25350981, KAKENHI-PROJECT-25750397, KAKENHI-PROJECT-26350976
[Journal Article] Terpendole E and its derivative inhibit STLC - and GSK-1-resistant Eg52014
- Author(s)
  Tarui Y, Chinen T, Nagumo Y, Motoyama T, Hayashi T, Hirota H, Muroi M, Ishii Y, Kondo H, Osada H, Usui T.
- Journal Title
  
  ChemBioChem
  
  Volume: (In press) Issue: 7 Pages: 934-938
- DOI
  10.1002/cbic.201300808
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J01199, KAKENHI-PROJECT-23580125, KAKENHI-PUBLICLY-24102536, KAKENHI-PROJECT-24710244
[Journal Article] Identification of a molecular target of a novel fungal metabolite, pyrrolizilactone, by phenotypic profiling systems.2013
- Author(s)
  Futamura Y, Kawatani M, Muroi M, Aono H, Nogawa T, Osada H,
- Journal Title
  
  ChemBioChem
  
  Volume: 14 Issue: 18 Pages: 2456-2463
- DOI
  10.1002/cbic.201300499
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24102536, KAKENHI-PROJECT-24248022, KAKENHI-PROJECT-25350981, KAKENHI-PROJECT-25750396
[Journal Article] Target identification of small molecules based on chemical biology approaches.2013
- Author(s)
  Yushi Futamura、他
- Journal Title
  
  Mol Biosyst
  
  Volume: 9 Issue: 5 Pages: 897-914
- DOI
  10.1039/c2mb25468a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25750396, KAKENHI-PUBLICLY-24102536
[Journal Article] Protein disulfide isomerase-mediated disulfide bonds regulate the gelatinolytic activity and secretion of matrix metalloproteinase-9.2012
- Author(s)
  Khan M. M., Simizu S., Suzuki T., Masuda, A., Kawatani M., Muroi M., Dohmae N., and Osada H.
- Journal Title
  
  Exp. Cell Res.
  
  Volume: 318 Pages: 904-914
- Data Source
  KAKENHI-PROJECT-22681034
[Journal Article] Protuboxepin A, a marine fungal metabolite, inducing metaphase arrest and chromosomal misalignment in tumor cells.2012
- Author(s)
  Y. Asami, J. H. Jang, N. K. Soung, L. He, D. O. Moon, J. W. Kim, H. Oh, M. Muroi, H. Osada, B. Y. Kim and J. S. Ahn
- Journal Title
  
  Bioorg Med Chem
  
  Volume: 20 Issue: 12 Pages: 3799-3806
- DOI
  10.1016/j.bmc.2012.04.039
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24102536
[Journal Article] Morphobase, an encyclopedic cell morphology database, and its use for drug target identification.2012
- Author(s)
  Futamura Y., Kawatani M., Kazami S., Tanaka K., Muroi M., Shimizu T., Tomita K., Watanabe N., and Osada H.
- Journal Title
  
  Chem. Biol.
  
  Volume: 19 Pages: 1620-1630
- Data Source
  KAKENHI-PROJECT-22681034
[Journal Article] Morphobase, an encyclopedic cell morphology database, and its use for drug target identification.2011
- Author(s)
  Futamura, Y., et al.
- Journal Title
  
  Chem Biol.
  
  Volume: 19 Issue: 12 Pages: 1620-1630
- DOI
  10.1016/j.chembiol.2012.10.014
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19057005, KAKENHI-PROJECT-22681034, KAKENHI-PROJECT-24248022, KAKENHI-PROJECT-24510320, KAKENHI-PUBLICLY-24102536
[Journal Article] Identification of a small-molecule inhibitor of DNA topoisomerase II by proteomic profiling.2011
- Author(s)
  Kawatani M., Takayama H., Muroi M., Kimura S., Maekawa T., and Osada H.
- Journal Title
  
  Chem. Biol.
  
  Volume: 18 Pages: 743-751
- Data Source
  KAKENHI-PROJECT-22681034
[Journal Article] Application of proteomic profiling based on 2D-DIGE for classification of compounds according to the mechanism of action.2010
- Author(s)
  Muroi M., Kazami S., Noda K., Kondo H., Takayama H., Kawatani M., Usui T., and Osada H.
- Journal Title
  
  Chem. Biol.
  
  Volume: 17 Pages: 460-470
- NAID
  120007137992
- Data Source
  KAKENHI-PROJECT-22681034
[Journal Article] Application of proteomic profiling based on 2D-DIGE for classification of compounds according to the mechanism of action2010
- Author(s)
  Muroi, M., et al.
- Journal Title
  
  Chem.Biol.
  
  Volume: 17 Pages: 460-470
- NAID
  120007137992
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22681034
[Journal Article] Polo-like kinase 1 phosphorylates and regulates Bcl-xL during pironetin-induced apoptosis.2009
- Author(s)
  Simizu, S. (7名中2番目), Muroi, M. (7名中3番目), Osada, H. (7名中7番目)
- Journal Title
  
  Oncogene 28
  
  Pages: 107-116
- NAID
  120006385868
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016079
[Journal Article] The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I.2008
- Author(s)
  Kanoh, N. (7名中4番目), Muroi, M. (7名中5番目), Osada, H. (11名中11番目)
- Journal Title
  
  Proc. Natl. Acad. Sci. USA. 105
  
  Pages: 11691-11696
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016079
[Journal Article] Involvement of disulfide bond formation in the activation of heparanase.2007
- Author(s)
  Simizu, S. (7名中1番目), Muroi, M. (7名中3番目), Osada, H. (7名中7番目)
- Journal Title
  
  Cancer Res. 67
  
  Pages: 7841-7849
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016079
[Journal Article] Iejimalides, the antitumor 24-membered macrolides, are novel V-ATPases inhibitors., Biosci.2006
- Author(s)
  Muroi, M. (7名中2番目), Osada, H. (7名中7番目)
- Journal Title
  
  Biotechnol. Biochem. 70
  
  Pages: 1364-1370
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016079
[Journal Article] Photo-crosslinked small molecule affinity matrix for facilitating forward and reverse chemical genetics.2005
- Author(s)
  Kanoh, N. (5名中1番目), Simizu, S. (5名中3番目), Muroi, M. (5名中4番目), Osada, H. (5名中5番目)
- Journal Title
  
  Angew. Chem. Int. Ed. 44
  
  Pages: 3559-3562
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016079
[Presentation] 抗カンジダ物質TPPBの構造活性相関とタンパク質－化合物間相互作用解析2024
- Author(s)
  青野晴美、二村友史、堀康宏、室井誠、平野弘之、本田香織、西浦正芳、侯召民、木野邦器、長田裕之
- Organizer
  日本農芸化学会 2024年度大会
- Data Source
  KAKENHI-PROJECT-21H04720
[Presentation] Proteomics-based target identification system for biological active compounds, ChemProteoBase and 2DE-CETSA2023
- Author(s)
  Makoto Muroi, Makoto Kawatani, Emiko Sanada, Naoshi Dohmae, and Hiroyuki Osada
- Organizer
  Future Drug Discovery Empowered by Chemical Biology (ChemBioNara2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K05857
[Presentation] 抗カンジダ物質TPPBの作用機序解析2023
- Author(s)
  青野晴美、二村友史、堀康宏、室井誠、平野弘之、西浦正芳、侯召民、木野邦器、長田裕之
- Organizer
  日本農芸化学会2023年度大会
- Data Source
  KAKENHI-PROJECT-21H04720
[Presentation] A novel inhibitor of fungal cell wall synthesis that targets RHO1 small GTPase2023
- Author(s)
  Yushi Futamura, Harumi Aono, Rachael Uson-Lopez, Yasuhiro Hori, Makoto Muroi, Hiroyuki Hirano, Masayoshi Nishiura, Zhaomine Hou, Hiroyuki Osada
- Organizer
  5th KRIBB-RIKEN Chemical Biology Joint Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04720
[Presentation] カンジダの細胞形態変化を指標とした抗真菌剤の探索2022
- Author(s)
  二村友史、ウソン－ロペスレイチェル、青野晴美、堀康宏、室井誠、平野弘之、西浦正芳、侯召民、長田裕之
- Organizer
  日本農芸化学会2022年度大会
- Data Source
  KAKENHI-PROJECT-21H04720
[Presentation] カンジダ細胞の表現型変化を指標とした抗真菌剤の探索2021
- Author(s)
  二村友史、ウソン－ロペスレイチェル A. 、青野晴美、堀康宏、渡邉慶子、室井誠、平野弘之、西浦正芳、侯召民、長田裕之
- Organizer
  日本ケミカルバイオロジー学会第15回年会
- Data Source
  KAKENHI-PROJECT-21H04720
[Presentation] 2DE-CETSAを用いたPKM2制御シグナルに作用する化合物NPD10084の同定2020
- Author(s)
  室井誠、永澤生久子、小川直子、川谷誠、大石智一、大庭俊一、川田学、長田裕之
- Organizer
  日本農芸化学会2020年度大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07783
[Presentation] ２次元電気泳動を用いた化合物に相互作用するたんぱく質の解析法（2DE-CETSA）の開発2019
- Author(s)
  室井誠、永澤生久子、池野あゆみ、小川直子、川谷誠、長田裕之
- Organizer
  日本農芸化学会2019年度大会
- Data Source
  KAKENHI-PROJECT-17K07783
[Presentation] Target identification of bioactive small molecules based on proteomic analyses using 2-D DIGE.2019
- Author(s)
  Makoto Muroi, Ikuko Nagasawa, Naoko Ogawa, Harumi Aono, Yushi Futamura, Makoto Kawatani, Hiroyuki Osada
- Organizer
  RIKEN-Max Planck Joint Research Center for System Chemical Biology 7th Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07783
[Presentation] Development of 2DE-CETSA as a novel platform by 2- dimensional electrophoresis based-proteomic analysis for target identification of small molecules2019
- Author(s)
  Ikuko Nagasawa, Makoto Muroi, Ayumi Ikeno, Naoko Ogawa, Makoto Kawatani, Hiroyuki Osada
- Organizer
  The 1st International Symposium on Chemical Communication (ISCC2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07783
[Presentation] ChemProteoBase を用いた化合物のオフターゲット解析2017
- Author(s)
  室井　誠、川谷　誠、河村　達郎、近藤　恭光、二村　友史、田中　美帆、青野　晴美、本田　香織、長田　裕之
- Organizer
  日本ケミカルバイオロジー学会　第12回年会
- Data Source
  KAKENHI-PROJECT-17K07783
[Presentation] 表現型データベースを用いた生理活性物質の標的分子解析2017
- Author(s)
  室井　誠
- Organizer
  日本農芸化学会　2017年度東北支部支部大会
- Invited
- Data Source
  KAKENHI-PROJECT-17K07783
[Presentation] ChemProteoBaseを用いたMTH1阻害剤の作用解析2017
- Author(s)
  室井　誠、川谷　誠、河村　達郎、近藤　恭光、二村　友史、田中　美帆、青野　晴美、本田　香織、長田　裕之
- Organizer
  日本農芸化学会2017年度大会
- Data Source
  KAKENHI-PROJECT-17K07783
[Presentation] ChemProteoBaseによるcollismycin Aの作用機作解析2014
- Author(s)
  室井誠, 近藤久恵, 平田泰子, 井上尭, 川谷誠, 長田裕之
- Organizer
  日本農芸化学会2014年度大会
- Place of Presentation
  明治大学生田キャンパス（神奈川県）
- Data Source
  KAKENHI-PROJECT-24248022
[Presentation] ChemProteoBaseによるcollismycin Aの作用機作解析2014
- Author(s)
  室井誠, 近藤久恵, 平田泰子, 井上尭, 川谷誠, 長田裕之
- Organizer
  日本農芸化学会2014年度大会
- Place of Presentation
  神奈川県、明治大学生田キャンパス
- Data Source
  KAKENHI-PUBLICLY-24102536
[Presentation] 放線菌由来抗がん性物質 collismycin A の作用標的同定2014
- Author(s)
  井上尭, 川谷誠, 室井誠, 二村友史, 青野晴美, 浦本昌和, 本郷やよい, 越野広雪, 五十嵐康弘, 安藤直子, 長田裕之
- Organizer
  日本農芸化学会2014年度大会
- Place of Presentation
  明治大学生田キャンパス（神奈川県）
- Data Source
  KAKENHI-PROJECT-24248022
[Presentation] 2D gel electrophoresis-based proteomic profiling approach to predict targets of bioactive small molecules (ProteoBase)2013
- Author(s)
  Muroi M., Kawatani M., Osada H.
- Organizer
  2nd Symposium of the RIKEN-Max Planck Joint Research Center
- Place of Presentation
  RIKEN, Wako, Saitama, Japan
- Data Source
  KAKENHI-PUBLICLY-24102536
[Presentation] 糸状菌由来新規抗がん活性物質pyrrolizilactoneの標的同定2013
- Author(s)
  川谷誠, 青野晴美, 野川俊彦, 二村友史, 室井誠, 渡辺信元, 長田裕之
- Organizer
  第17回日本がん分子標的治療学会学術集会
- Place of Presentation
  国立京都国際会館（京都府）
- Data Source
  KAKENHI-PROJECT-24248022
[Presentation] Identification of a target for collismycin A, a cytotoxic microbial product, by proteomic profiling2013
- Author(s)
  Makoto Kawatani, Gyo Inoue, Makoto Muroi, Yushi Futamura, Harumi Aono, Masakazu Uramoto, Yayoi Hongo, Hiroyuki Koshino, Yasuhiro Igarashi, Naoko Takahashi Ando, Hiroyuki Osada
- Organizer
  AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
- Place of Presentation
  Hynes Convention Center (Boston, MA, USA)
- Data Source
  KAKENHI-PROJECT-24248022
[Presentation] Development and utilization of a cell morphology database, MorphoBase, for drug target identification2013
- Author(s)
  Yushi Futamura, Makoto Kawatani, Makoto Muroi, Harumi Aono, Hiroyuki Osada
- Organizer
  AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
- Place of Presentation
  Hynes Convention Center (Boston, MA, USA)
- Data Source
  KAKENHI-PROJECT-24248022
[Presentation] Identification of molecular target of pyrrolizilactone by ChemProteoBase.2013
- Author(s)
  Muroi M, Futamura Y, Kawatani M, Nogawa T, Osada H, 2013 Oct
- Organizer
  The 2nd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity,.
- Place of Presentation
  PACIFICO YOKOHAMA, Yokohama, Japan
- Data Source
  KAKENHI-PUBLICLY-24102536
[Presentation] プロテオミクス的プロファイリング法による新規化合物ピロリジラクトンの標的同定予測2013
- Author(s)
  2013年 5月28日～29日, 室井　誠、川谷　誠、野川俊彦、長田　裕之
- Organizer
  天然物ケミカルバイオロジー～分子標的と活性制御～　第４回公開シンポジウム
- Place of Presentation
  茨城県、つくば市つくば国際会議場
- Data Source
  KAKENHI-PUBLICLY-24102536
[Presentation] Proteobaseを用いた新規プロテアソーム阻害剤ピロリジラクトンの標的同定2013
- Author(s)
  室井　誠、他
- Organizer
  日本農芸化学会2013年度大会
- Place of Presentation
  東北大学川内北キャンパス（宮城県）
- Data Source
  KAKENHI-PROJECT-24248022
[Presentation] 細胞形態とプロテオーム変化を指標にした新規抗がん剤の分子標的予測2013
- Author(s)
  長田裕之, 二村友史, 室井誠
- Organizer
  第17回日本がん分子標的治療学会学術集会
- Place of Presentation
  国立京都国際会館（京都府）
- Invited
- Data Source
  KAKENHI-PROJECT-24248022
[Presentation] Proteobaseを用いた新規プロテアソーム阻害剤ピロリジラクトンの標的同定2013
- Author(s)
  室井誠、近藤久恵、平田泰子、青野晴美、川谷誠、野川俊彦、長田裕之
- Organizer
  日本農芸化学会２０１３年度大会
- Place of Presentation
  仙台
- Year and Date
  2013-03-24
- Data Source
  KAKENHI-PUBLICLY-24102536
[Presentation] Identification of novel tubulin polymerization inhibitors by proteomic profiling2012
- Author(s)
  Makoto Kawatani, Makoto Muroi, and Hiroyuki Osada
- Organizer
  The 16th JFCR-ISCC
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-22681034
[Presentation] 薬剤標的同定の為のプロテオミクス的プロファイリング法2012
- Author(s)
  室井誠、長田裕之
- Organizer
  新学術領域研究「天然物ケミカルバイオロジー～分子標的と活性制御～」第2回公開シンポジウム
- Place of Presentation
  東京
- Year and Date
  2012-06-17
- Data Source
  KAKENHI-PUBLICLY-24102536
[Presentation] Proteome-based profiling approach to predict targets of bioactive small molecules using two-dimensional fluorescence differential gel electrophoresis (2D-DIGE)2012
- Author(s)
  M. Muroi and H. Osada
- Organizer
  The 1st International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity.
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2012-10-31
- Data Source
  KAKENHI-PUBLICLY-24102536
[Presentation] Proteome- and cell morphology-based target identification for RKB3564F070, a new cytotoxic fungal metabolite2012
- Author(s)
  Makoto Kawatani, Harumi Aono, Toshihiko Nogawa, Makoto Muroi, Yushi Futamura, and Hiroyuki Osada
- Organizer
  The 1st official conference of the international chemical biology society
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-22681034
[Presentation] Identification of a molecular target for RKB3564F070, a new cytotoxic fungal metabolite2012
- Author(s)
  川谷誠、青野晴美、室井誠、二村友史、長田裕之
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22681034
[Presentation] プロテオームプロファイリングによるチューブリン重合阻害剤の同定2011
- Author(s)
  川谷誠、富田康司、風見紗弥香、青野晴美、室井誠、清水猛、長田裕之
- Organizer
  第15回日本がん分子標的治療学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22681034
[Presentation] プロテオームプロファイリングによるチューブリン重合阻害剤の同定2011
- Author(s)
  川谷誠、青野晴美、室井誠、長田裕之
- Organizer
  第70回日本癌学会学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22681034
[Presentation] Identification of novel tubulin polymerization inhibitors by proteomic profiling2011
- Author(s)
  Makoto Kawatani, Kouji Tomita, Makoto Muroi, Sayaka Kazami, Harumi Aono, Takeshi Shimizu, and Hiroyuki Osada
- Organizer
  AACR-NCI-EORTC International Conference "Molecular Targets and Cancer Therapeutics"
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-22681034
[Presentation] GO-Y086のプロテオミクス解析を用いた作用標的の推測2010
- Author(s)
  室井誠
- Organizer
  日本農芸化学会2010年度大会
- Place of Presentation
  東京大学駒場キャンパス(東京)
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-17016079
[Presentation] 薬剤処理HeLa細胞のプロテオームプロファイリングシステムの拡張2009
- Author(s)
  室井誠, 野田和恵, 近藤久恵, 仲田優子, 星元紀, 長田裕之
- Organizer
  日本農芸化学会
- Place of Presentation
  福岡市福岡国際会議場
- Data Source
  KAKENHI-PROJECT-19658047
[Presentation] 薬剤処理 HeLa 細胞のプロテオームプロファイリングシステムの拡張2009
- Author(s)
  室井誠, 他
- Organizer
  日本農芸化学会2009年度大会
- Place of Presentation
  福岡国際会議場 (福岡)
- Data Source
  KAKENHI-PROJECT-17016079
[Presentation] 薬剤処理HeLa細胞のプロテオームプロファイリングシステムの拡張2009
- Author(s)
  室井誠
- Organizer
  日本農芸化学会2009年度大会
- Place of Presentation
  福岡国際会議場(福岡)
- Data Source
  KAKENHI-PROJECT-17016079
[Presentation] GUT-70、並びに、誘導体BNS-22のプロテオミクスを用いた作用標的解析2008
- Author(s)
  室井誠, 風見紗弥香, 高山浩, 川谷誠, 木村晋也, 前川平, 長田裕之
- Organizer
  第12回がん分子標的治療研究会
- Place of Presentation
  東京都千代田区学術総合センター
- Data Source
  KAKENHI-PROJECT-19658047
[Presentation] GUT-70、並びに、誘導体 BNS-22 のプロテオミクスを用いた作用標的解析2008
- Author(s)
  室井誠, 他
- Organizer
  第12回がん分子標的治療研究会
- Place of Presentation
  学術総合センター (東京)
- Data Source
  KAKENHI-PROJECT-17016079
[Presentation] ChemProteoBaseのがん代謝作用薬解析に向けた応用
- Author(s)
  室井誠, 田中美帆, 川谷誠, 長田裕之
- Organizer
  日本農芸化学会2015年度大会
- Place of Presentation
  岡山大学津島キャンパス（岡山県）
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-24248022

1. OSADA Hiroyuki (80160836)

# of Collaborated Projects: 4 results

# of Collaborated Products: 19 results
2. SUDO Tatsuhiko (30260227)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. UEKI Masashi (90312264)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. SIMIZU Siro (30312268)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. KAWATANI Makoto (50391925)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
6. FUTAMURA Yushi (70525857)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
7. KANOH Naoki (40317293)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. NOGAWA Toshihiko (40462717)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. USUI Takeo (60281648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. NISHIKAWA Toshio (90208158)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. IMOTO Masaya (60213253)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 河岸洋和 (70183283)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 天池一真 (00866600)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 鈴木智大 (10649601)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 高橋公咲 (30374622)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 謝肖男 (30610323)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 野村崇人 (60373346)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 大内仁志 (70798842)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 一家崇志 (90580647)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 菅敏幸 (10221904)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 伊藤英人 (70706704)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 木野邦器 (60318764)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
23. 堂前直 (00321787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. KAZAMI Sayaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
25. HONDA Kaori

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 田代悦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 近藤恭光

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
28. 大石智一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MUROI Makoto 室井 誠

室井 誠 ムロイ マコト

Research Projects

Research Products

Co-Researchers

MSベースのプロテオームプロファイリングに基づく薬剤標的解析システムの構築Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Exploration of antifungals based on AI-based screening systems

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

プロテオーム解析を用いた直接的アプローチ法による薬剤標的同定解析システムの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Science of fairy chemicals and their application development

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of compound evaluation system based on pathway analysis using proteome analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanism of neuroprotective activity of geldanamycin

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

薬剤標的同定の為のプロテオミクス的プロファイリング法の改良と利用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Construction of the database of microbial products and its application study

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of anti-cancer agents targeting the endocytic pathway

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

プロテオミックス的手法を用いた薬剤作用解析システムの構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Drug discovery research based on the molecular mechanisms of tumor growth and metastasis

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Analysis of interaction between microtubule-associated protein/microtubule-targeting agents and single allele tubulin.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

選択的阻害剤を用いたスフィンゴ脂質の合成と細胞内転送過程の解析Principal Investigator

Principal Investigator

Project Period (FY)

MUROI Makoto 室井誠

室井誠ムロイマコト

[Book] 医薬品開発におけるオミクス解析技術～ゲノム・トランスクリプトーム・プロテオーム・メタボローム～2020