Shimizu Toshiyuki 清水敏之

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SHIMIZU Toshiyuki 清水敏之

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Researcher Number	30273858
Other IDs
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Affiliation (Current)	2025: 東京大学, 大学院薬学系研究科(薬学部), 教授
Affiliation (based on the past Project Information) *help	2016 – 2024: 東京大学, 大学院薬学系研究科(薬学部), 教授 2015: 東京大学, 薬学系研究科, 教授 2012 – 2015: 東京大学, 薬学研究科(研究院), 教授 2010 – 2012: 東京大学, 大学院・薬学系研究科, 教授 2009: Yokohama City University, 生命ナノシステム科学研究科, 准教授 … More 2006 – 2008: Yokohama City University, International Graduate School of Arts and Sciences, Associate Professor, 国際総合科学研究科, 准教授 2005 – 2006: 横浜市立大学, 国際総合科学研究科, 準教授 2003 – 2004: 横浜市立大学, 大学院・総合理学研究科, 助教授 2001 – 2002: 横浜市立大学, 総合理学研究科, 助教授 1996 – 2000: 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助手 1996: 奈良先端科学技術大学院大学, バイオサイエンズ研究科, 助手 Less
Review Section/Research Field	Principal Investigator Structural biochemistry / Biophysics / Biological Sciences / Biological Sciences / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Medium-sized Section 47:Pharmaceutical sciences and related fields Except Principal Investigator 広領域 / Medium-sized Section 39:Agricultural and environmental biology and related fields / Transformative Research Areas, Section (III) / Biological Sciences / Biophysics / Structural biochemistry / Biological Sciences
Keywords	Principal Investigator X線結晶解析 / X線結晶構造解析 / Toll様受容体 / EF-hand / 自然免疫 / X-ray analysis / カルシウム / ヒストン / クライオ電子顕微鏡 / 構造生物学 … More / 構造生物 / TLR / Nod様受容体 / DRAK2 / NHE1 / CHP / calcineurin / calcium / カルシニューリン / CIPK / CBL2 / Merlin / Ｘ線結晶構造解析 / Ｘ線結晶解析 / リコンビナーゼ / メディエーター / 相同組み換え / EFハンド / Nucleomethylin / βターン / アルギニン / PAD4 / 立体構造 / 転写因子 / X線解析 / CryoEM / トランスポーター / リソソーム / 糖鎖 / Orientation bias / NLR / plant / カルシウムセンサー / 植物 / FERM domain / ERM protein / tertiary structure / auto-inhibition / Rho-signalling / Rho-kinase / Rho / DHドメイン / コイルドコイル / Rho-キナーゼ / FERMドメイン / ERMタンパク質 / 自己阻害 / Rhoシグナリング / Rhoキナーゼ / １本鎖核酸 / 一本鎖核酸 / Swi5-Sfr1 / p53 / Mybbpla / Ｘ線小角散乱 / Smad / ビタミンDレセプター / X線小角散乱 / 核内受容体 / Roquin / アルギニンメチル化酵素 / SAM / 翻訳後修飾 / PRMT / アルギニンメチル化 / Rac1 / Rboh / 活性酸素 / methyltransferase / rRNA / 天然変性 / eNoSC / 核小体 / シトルリン / シトルリン化 / 制御因子 / リン酸化 / 蛋白キナーゼ / CK2 / 蛋白質核酸複合体 / 蛋白質.核酸複合体 / 分子認識 / bHLH / Pho4 / 結晶 / ヘリックスループヘリックス / 出芽酵母 / 三次元構造 / 核酸蛋白質相互作用 … More Except Principal Investigator DNA / 構造生物学 / X線 / 分子認識 / ICAM-2 / Rho / structural biology / X-ray / molecular complex / protein / G protein / signal transduction / transcription / 結晶 / 複合体 / 蛋白質 / 転写因子 / シグナル伝達 / エフェクター / 病原体 / 受容体 / 植物免疫 / 自然免疫 / Toll様受容体 / 転写環境 / エネルギー代謝 / hub metabolite / エピジェネティクス / クロマチン / 翻訳後修飾 / 生命素子 / 代謝 / 転写 / adhesion molecules / cytoskeleton / PTP2 / 細胞接着 / 細胞骨格 / PIP2 / イメージングプレート / ミラー / 光学系 / 回折 / 微小結晶 / 二成分系 / G蛋白質 / 蛋白質-DNA / DNA修復 / メディエーター / DNA 修復 / 相同組換え / アロステリック / ジストニア / 金属 / 塩基配列 / DNA結合モチーフ / bHLH / bZIP / 融合蛋白質 / DNA複製 / 結晶化 Less

Plant NLR activation and evolution of pathogen effectors for inhibition of the NLR function
- Principal Investigator
  
  川崎努
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 39:Agricultural and environmental biology and related fields
- Research Institution
  Kindai University
Lysosomes as the starting point of innate immune responses - importance of lysosomal environment -Principal Investigator
- Principal Investigator
  
  清水敏之
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  The University of Tokyo
Molecular and structural bases enabling self-derived nucleic acid recognition in lysosomes
- Principal Investigator
  
  三宅健介
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  The University of Tokyo
Overcoming the problems in CryoEM analysis using sugar chain and its application to the innate immune receptor, TLRPrincipal Investigator
- Principal Investigator
  
  Shimizu Toshiyuki
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo
Elucidation of molecular motion and new regulation mechanisms in innate immune sensorsPrincipal Investigator
- Principal Investigator
  
  Shimizu Toshiyuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  The University of Tokyo
Structural basis of proteins related with innate immunityPrincipal Investigator
- Principal Investigator
  
  Shimizu Toshiyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  The University of Tokyo
Structural studies of nucleic acid sensing Toll-like receptorsPrincipal Investigator
- Principal Investigator
  
  Shimizu Toshiyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  The University of Tokyo
Structural analysis of the transcription environment factors that engage in crosstalk with metabolic pathwaysPrincipal Investigator
- Principal Investigator
  
  Shimizu Toshiyuki
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
リコンビナーゼとその活性化因子との複合体構造を通した鎖交換反応の構造基盤の確立Principal Investigator
- Principal Investigator
  
  清水敏之
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Structure-function relationships of Rad51-Swi5-Sfr1 complex for homologous recombination
- Principal Investigator
  
  KUWABARA Naoyuki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  High Energy Accelerator Research Organization
  The University of Tokyo
Crosstalk of transcriptional control and energy pathways by hub metabolites
- Principal Investigator
  
  FUKAMIZU Akiyoshi
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tsukuba
Structural studies of a novel mediator regulating homologous recombinationPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Toshiyuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  The University of Tokyo
植物自然免疫を担う活性酸素生成酵素の制御機構の構造生物学的解明Principal Investigator
- Principal Investigator
  
  清水敏之
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
  Yokohama City University
メチル基転移領域を有する新規核小体蛋白質とその複合体の構造基盤の確立Principal Investigator
- Principal Investigator
  
  清水敏之
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
立体構造を基にしたヒストン修飾酵素の認識機構の解明Principal Investigator
- Principal Investigator
  
  清水敏之
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
ヒストン修飾酵素によるヒストン認識機構の構造的基盤Principal Investigator
- Principal Investigator
  
  清水敏之
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
Structural study for the recognition mechanism of the target protein by a novel calcium sensorPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Toshiyuki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Yokohama City University
Structural study for the novel regulation mechanism by calcium ionPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Toshiyuki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Yokohama City University
Structural basis for auto-inhibition mechanism of Rho-kinasePrincipal Investigator
- Principal Investigator
  
  SHIMIZU Toshiyuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Yokohama City University
X線結晶解析による金属蛋白質の構造生物化学
- Principal Investigator
  
  箱嶋敏雄
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nara Institute of Science and Technology
「Structural biology of the small G protein Rho by X-ray analyses of the molecular complexes」
- Principal Investigator
  
  HAKOSHIMA Toshio
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  広領域
- Research Institution
  NARA INSTITUTE OF SCIENCE AND TECHNOLOGY
制御因子が機能をコントロールする蛋白キナーゼCK2の構造的基盤Principal Investigator
- Principal Investigator
  
  清水敏之
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biophysics
- Research Institution
  Nara Institute of Science and Technology
In-house X-ray intensity data-collection system for macromolecular complex crystals
- Principal Investigator
  
  HAKOSHIMA Toshio
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  広領域
- Research Institution
  Nara Institute of Science and Technology
L-Mafを中心とした転写因子のX線構造生物学的研究
- Principal Investigator
  
  箱嶋敏雄
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nara Institute of Science and Technology
立体構造をもとにした酵母由来の転写因子Pho4による分子認識機構の解明Principal Investigator
- Principal Investigator
  
  清水敏之
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biophysics
- Research Institution
  Nara Institute of Science and Technology
Structural Studies of Molecular Recognition by Proteins : X-ray Analyses of Complex Crystals
- Principal Investigator
  
  HAKOSHIMA Toshio
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biophysics
- Research Institution
  Nara Institute of Science and Technology
複製関連調節因子DREF・DNA複合体のX線構造解析
- Principal Investigator
  
  HAKOSHIMA Toshio
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nara Institute of Science and Technology
酵母由来の転写因子PHO4の全体構造の解明Principal Investigator
- Principal Investigator
  
  清水敏之
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biophysics
- Research Institution
  Nara Institute of Science and Technology

[Book] 「入門構造生物学」(「転写)部分を担当)2010
- Author(s)
  清水敏之
- Total Pages
  199
- Publisher
  共立出版
- Data Source
  KAKENHI-PROJECT-22370045
[Book] タンパク質核酸相互作用タンパク質科学構造・物性・機能2005
- Author(s)
  清水敏之, 箱嶋敏雄
- Total Pages
  579
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-17054035
[Book] 「タンパク質核酸相互作用」タンパク質科学構造・物性・機能2005
- Author(s)
  清水敏之, 箱嶋敏雄
- Total Pages
  579
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-17570095
[Journal Article] TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction2023
- Author(s)
  Sakaniwa Kentaro、Fujimura Akiko、Shibata Takuma、Shigematsu Hideki、Ekimoto Toru、Yamamoto Masaki、Ikeguchi Mitsunori、Miyake Kensuke、Ohto Umeharu、Shimizu Toshiyuki
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 164-164
- DOI
  10.1038/s41467-023-35844-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19207, KAKENHI-PROJECT-23K23820, KAKENHI-PROJECT-22K19424, KAKENHI-PLANNED-22H05184, KAKENHI-PROJECT-21H04800, KAKENHI-PROJECT-23H00366
[Journal Article] Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome2023
- Author(s)
  Zhang Zhikuan、Shibata Takuma、Fujimura Akiko、Kitaura Jiro、Miyake Kensuke、Ohto Umeharu、Shimizu Toshiyuki
- Journal Title
  
  Nature
  
  Volume: 622 Issue: 7981 Pages: 188-194
- DOI
  10.1038/s41586-023-06532-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K18211, KAKENHI-PROJECT-22K19424, KAKENHI-PROJECT-22K15046, KAKENHI-PLANNED-22H05184, KAKENHI-PROJECT-21H04800, KAKENHI-PROJECT-23K23820, KAKENHI-PROJECT-23K27637
[Journal Article] TLR7/8 stress response drives histiocytosis in SLC29A3 disorders2023
- Author(s)
  Shibata Takuma、Sato Ryota、Taoka Masato、Saitoh Shin-Ichiroh、Komine Mayumi、（他16人）、Ohto Umeharu、Shimizu Toshiyuki、Ozawa Manabu、Yoshida Nobuaki、Isobe Toshiaki、Latz Eicke、Mukai Kojiro、Taguchi Tomohiko、Hemmi Hiroaki、Akira Shizuo、Miyake Kensuke
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 220 Issue: 9 Pages: 320230054-320230054
- DOI
  10.1084/jem.20230054
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18211, KAKENHI-PROJECT-21K06956, KAKENHI-PROJECT-22K19424, KAKENHI-PROJECT-20H03162, KAKENHI-PLANNED-22H05184, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21H04800, KAKENHI-PROJECT-23H00366, KAKENHI-PROJECT-23K23820, KAKENHI-PROJECT-23K27084, KAKENHI-PROJECT-23K27637
[Journal Article] A novel Toll-like receptor 7/8-specific antagonist E6742 ameliorates clinically relevant disease parameters in murine models of lupus2023
- Author(s)
  Ishizaka Sally T.、Hawkins Lynn、Chen Qian、Tago Fumitoshi、Yagi Takuya、Sakaniwa Kentaro、Zhang Zhikuan、Shimizu Toshiyuki、Shirato Manabu
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 957 Pages: 175962-175962
- DOI
  10.1016/j.ejphar.2023.175962
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15046, KAKENHI-PROJECT-23H00366
[Journal Article] Role of the orphan transporter SLC35E1 in the nuclear egress of herpes simplex virus 12022
- Author(s)
  Fumio Maeda, Akihisa Kato, Kosuke Takeshima, Misato Shibazaki, Ryota Sato, Takuma Shibata, Kensuke Miyake, Hiroko Kozuka-Hata, Masaaki Oyama, Eigo Shimizu, Seiya Imoto, Satoru Miyano, Shungo Adachi, Tohru Natsume, Koh Takeuchi, Yuhei Maruzuru, Naoto Koyanagi, Jun Arii, Yasushi Kawaguchi
- Journal Title
  
  Journal of Virology
  
  Volume: - Issue: 10 Pages: 10-10
- DOI
  10.1128/jvi.00306-22
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22524, KAKENHI-PROJECT-20K07511, KAKENHI-PROJECT-21K19370, KAKENHI-PROJECT-21K19498, KAKENHI-PROJECT-22K15468, KAKENHI-PLANNED-21H05280, KAKENHI-PLANNED-22H05184, KAKENHI-PUBLICLY-22H05584, KAKENHI-PROJECT-21H04800, KAKENHI-PROJECT-20H03496, KAKENHI-PROJECT-21K15464, KAKENHI-PROJECT-20H05692, KAKENHI-PROJECT-20H03492, KAKENHI-PUBLICLY-21H00338, KAKENHI-PUBLICLY-21H00417, KAKENHI-WRAPUP-22H04899, KAKENHI-PROJECT-20H03378
[Journal Article] Cryo-EM structures of Toll-like receptors in complex with UNC93B12021
- Author(s)
  Ishida Hanako、Asami Jinta、Zhang Zhikuan、Nishizawa Tomohiro、Shigematsu Hideki、Ohto Umeharu、Shimizu Toshiyuki
- Journal Title
  
  Nature Structural & Molecular Biology
  
  Volume: 28 Issue: 2 Pages: 173-180
- DOI
  10.1038/s41594-020-00542-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15730, KAKENHI-PROJECT-20K16274, KAKENHI-PUBLICLY-19H04950, KAKENHI-PROJECT-19H03164, KAKENHI-PROJECT-18K06172, KAKENHI-PROJECT-19H00976
[Journal Article] Improving particle quality in cryo-EM analysis using a PEGylation method2021
- Author(s)
  Zhang Zhikuan、Shigematsu Hideki、Shimizu Toshiyuki、Ohto Umeharu
- Journal Title
  
  Structure
  
  Volume: 29 Issue: 10 Pages: 1192-1199.e4
- DOI
  10.1016/j.str.2021.05.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15730, KAKENHI-PROJECT-19H03164, KAKENHI-PROJECT-21K19207, KAKENHI-PROJECT-21K19328
[Journal Article] Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists2021
- Author(s)
  Yang Yi、Csakai Adam、Jiang Shuangshuang、Smith Christina、Tanji Hiromi、Huang Jian、Jones Torey、Sakaniwa Kentaro、Broadwell Lindsey、Shi Chengrui、Soti Subada、Ohto Umeharu、Fang Yaohui、Shen Shu、Deng Fei、Shimizu Toshiyuki、Yin Hang
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 4351-4351
- DOI
  10.1038/s41467-021-24536-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H00976, KAKENHI-PROJECT-19H03164, KAKENHI-PROJECT-19J21830, KAKENHI-PROJECT-21K19207
[Journal Article] Structural and functional understanding of the toll‐like receptors2021
- Author(s)
  Asami Jinta、Shimizu Toshiyuki
- Journal Title
  
  Protein Science
  
  Volume: 30 Issue: 4 Pages: 761-772
- DOI
  10.1002/pro.4043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H00976
[Journal Article] Structural analysis reveals TLR7 dynamics underlying antagonism2020
- Author(s)
  Tojo Shingo、Zhang Zhikuan、Matsui Hiroyuki、Tahara Masahiro、Ikeguchi Mitsunori、Kochi Mami、Kamada Mami、Shigematsu Hideki、Tsutsumi Akihisa、Adachi Naruhiko、Shibata Takuma、Yamamoto Masaki、Kikkawa Masahide、Senda Toshiya、Isobe Yoshiaki、Ohto Umeharu、Shimizu Toshiyuki
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 1-11
- DOI
  10.1038/s41467-020-19025-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15730, KAKENHI-PUBLICLY-19H04950, KAKENHI-PROJECT-19H00976, KAKENHI-PROJECT-19H03164, KAKENHI-PROJECT-19H03197, KAKENHI-PROJECT-18K06172, KAKENHI-PROJECT-19H03451
[Journal Article] Discovery of Novel Small Molecule Dual Inhibitors Targeting Toll-like Receptor 7 and 82019
- Author(s)
  Padilla-Salinas, R., Anderson, R., Sakaniwa, K., Zhang, S., Nordeen, P., Lu, C., Shimizu, T., Yin, H.
- Journal Title
  
  J.Med.Chem.
  
  Volume: 62 Issue: 22 Pages: 10221-20244
- DOI
  10.1021/acs.jmedchem.9b01201
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H00976, KAKENHI-PROJECT-19J21830
[Journal Article] Structural Insights into the Regulation Mechanism of Small GTPases by GEFs.2019
- Author(s)
  Toma-Fukai S, Shimizu T
- Journal Title
  
  Molecules
  
  Volume: 24 Issue: 18 Pages: 3308-3308
- DOI
  10.3390/molecules24183308
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H00976
[Journal Article] Mechanisms controlling nucleic acid-sensing Toll-like receptors2018
- Author(s)
  Miyake Kensuke、Shibata Takuma、Ohto Umeharu、Shimizu Toshiyuki、Saitoh Shin-Ichiroh、Fukui Ryutaro、Murakami Yusuke
- Journal Title
  
  International Immunology
  
  Volume: 30 Issue: 2 Pages: 43-51
- DOI
  10.1093/intimm/dxy016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293083, KAKENHI-PUBLICLY-17H05991, KAKENHI-PROJECT-16K15253, KAKENHI-PUBLICLY-18H04666, KAKENHI-PUBLICLY-18H04856, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-17K19548, KAKENHI-PROJECT-16K08827
[Journal Article] Structural basis for species-specific activation of mouse Toll-like receptor 92018
- Author(s)
  Ishida Hanako、Ohto Umeharu、Shibata Takuma、Miyake Kensuke、Shimizu Toshiyuki
- Journal Title
  
  FEBS Letters
  
  Volume: 592 Issue: 15 Pages: 2636-2646
- DOI
  10.1002/1873-3468.13176
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05991, KAKENHI-PUBLICLY-18H04669, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16K08827
[Journal Article] Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation2018
- Author(s)
  Ohto Umeharu、Ishida Hanako、Shibata Takuma、Sato Ryota、Miyake Kensuke、Shimizu Toshiyuki
- Journal Title
  
  Immunity
  
  Volume: 48 Issue: 4 Pages: 649-658
- DOI
  10.1016/j.immuni.2018.03.013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05991, KAKENHI-PUBLICLY-18H04669, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16K08827
[Journal Article] Small-Molecule TLR8 Antagonists via Structure-Based Rational Design2018
- Author(s)
  Hu Zhenyi、Tanji Hiromi、Jiang Shuangshuang、Zhang Shuting、Koo Kyoin、Chan Jean、Sakaniwa Kentaro、Ohto Umeharu、Candia Albert、Shimizu Toshiyuki、Yin Hang
- Journal Title
  
  Cell Chemical Biology
  
  Volume: 25 Issue: 10 Pages: 1286-1291
- DOI
  10.1016/j.chembiol.2018.07.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05991, KAKENHI-PUBLICLY-18H04669, KAKENHI-PROJECT-16H02494
[Journal Article] Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands2018
- Author(s)
  Zhang Zhikuan、Ohto Umeharu、Shibata Takuma、Taoka Masato、Yamauchi Yoshio、Sato Ryota、Shukla Nikunj M.、David Sunil A.、Isobe Toshiaki、Miyake Kensuke、Shimizu Toshiyuki
- Journal Title
  
  Cell Reports
  
  Volume: 25 Issue: 12 Pages: 3371-3381
- DOI
  10.1016/j.celrep.2018.11.081
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05991, KAKENHI-PUBLICLY-18H04669, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-18J14570, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16K08827
[Journal Article] Small-molecule inhibition of TLR8 through stabilization of its resting state2018
- Author(s)
  Zhang, S., Hu, Z., Tanji, H., Jiang, S., Das, N, Li, J., Sakaniwa, K., Jin, J., Bian, Y., Ohto, U., Shimizu, T., Yin, H.
- Journal Title
  
  Nature Chem. Biol.
  
  Volume: 14 Issue: 1 Pages: 58-64
- DOI
  10.1038/nchembio.2518
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05991, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-15J12485
[Journal Article] Towards a structural understanding of nucleic acid-sensing Toll-like receptors in the innate immune system2017
- Author(s)
  Zhang Z, Ohto U, Shimizu T
- Journal Title
  
  FEBS letters
  
  Volume: 591 Pages: 3167-3181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02494
[Journal Article] Emerging roles of the processing of nucleic acids and Toll-like receptors in innate immune responses to nucleic acids2017
- Author(s)
  Miyake K, Shibata T, Ohto U, Shimizu T
- Journal Title
  
  J Leukoc Biol
  
  Volume: 101 Issue: 1 Pages: 135-142
- DOI
  10.1189/jlb.4mr0316-108r
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-26711002, KAKENHI-PROJECT-15K14471, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-16K08827
[Journal Article] The crystal structure of the AhRR-ARNT heterodimer reveals the structural basis of the repression of AhR-mediated transcription2017
- Author(s)
  Sakurai, S., Shimizu, T., & *Ohto, U.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 292 Issue: 43 Pages: 17609-17616
- DOI
  10.1074/jbc.m117.812974
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05991, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-17J10586
[Journal Article] Structural insights into ligand recognition and regulation of nucleic acid-sensing Toll-like receptors2017
- Author(s)
  Shimizu T
- Journal Title
  
  Curr. Opi. Struc. Biol.
  
  Volume: 47 Pages: 52-59
- DOI
  10.1016/j.sbi.2017.05.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02494
[Journal Article] Identification of a Human Toll-Like Receptor (TLR) 8-Specific Agonist and a Functional Pan-TLR Inhibitor in 2-Aminoimidazoles.2016
- Author(s)
  Beesu, M., Caruso, G., Salyer, A. C., Shukla, N. M., Khetani, K. K., Smith, L. J., Fox, L. M., Tanji, H., Ohto, U., Shimizu, T., & David, S. A.
- Journal Title
  
  J. Med. Chem.
  
  Volume: 59 Issue: 7 Pages: 3311-3330
- DOI
  10.1021/acs.jmedchem.6b00023
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14471, KAKENHI-PROJECT-26711002, KAKENHI-PROJECT-16H02494
[Journal Article] Novel helical assembly in arginine methyltransferase 82016
- Author(s)
  Toma-Fukai S, Kim JD, Park KE, Kuwabara N, Shimizu N, Krayukhina E, Uchiyama S, Fukamizu A, Shimizu T
- Journal Title
  
  Journal of Molecular Biology
  
  Volume: 428 Issue: 6 Pages: 1197-1208
- DOI
  10.1016/j.jmb.2016.02.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K14707, KAKENHI-ORGANIZER-23116001, KAKENHI-PLANNED-23116004, KAKENHI-PLANNED-23116007, KAKENHI-PROJECT-25252062, KAKENHI-PROJECT-26840029, KAKENHI-WRAPUP-16H01688
[Journal Article] Autoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8.2016
- Author(s)
  Tanji, H., Ohto, U., Motoi, Y., Shibata, T., Miyake, K., & Shimizu, T.
- Journal Title
  
  Proc. Natl. Acad. Sci. U S A
  
  Volume: 113 Issue: 11 Pages: 3012-3017
- DOI
  10.1073/pnas.1516000113
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K14471, KAKENHI-PROJECT-26711002, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-15J12485, KAKENHI-PROJECT-16K08827
[Journal Article] Guanosine and its modified derivatives are endogenous ligands for TLR72016
- Author(s)
  Shibata T, Ohto U, Nomura S, Kibata K, Motoi Y, Zhang Y, Murakami Y, Fukui R, Ishimoto T, Sano S, Ito T, Shimizu T, Miyake K.
- Journal Title
  
  Int Immunol
  
  Volume: - Issue: 5 Pages: 211-222
- DOI
  10.1093/intimm/dxv062
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15148, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-16H02629, KAKENHI-PROJECT-16K08827
[Journal Article] Crystal structure of NOD2 and its implications in human disease.2016
- Author(s)
  Maekawa S, Ohto U, Shibata T, Miyake K, Shimizu T
- Journal Title
  
  Nat Commun
  
  Volume: 7 Issue: 1 Pages: 11813-11813
- DOI
  10.1038/ncomms11813
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-26711002, KAKENHI-PROJECT-15K14471
[Journal Article] Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA2016
- Author(s)
  Zhang Z, Ohto U, Shibata T, Krayukhina E, Taoka M, Yamauchi Y, Tanji H, Isobe T, Uchiyama S, Miyake K, Shimizu T
- Journal Title
  
  Immunity
  
  Volume: 45 Issue: 4 Pages: 737-748
- DOI
  10.1016/j.immuni.2016.09.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-15J12485, KAKENHI-PROJECT-26711002, KAKENHI-PROJECT-15K14471, KAKENHI-PROJECT-16K08827
[Journal Article] Structure-based Design of Human TLR8-specific Agonists with Augmented Potency and Adjuvanticity.2015
- Author(s)
  Beesu, M., Caruso, G., Salyer, A., Khetani, K., Sil, D., Weerasinghe, M., Tanji, H., Ohto, U., Shimizu, T., & David, S. A.
- Journal Title
  
  J. Med. Chem.
  
  Volume: 58 Issue: 19 Pages: 7833-7849
- DOI
  10.1021/acs.jmedchem.5b01087
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14471, KAKENHI-PROJECT-15J12485, KAKENHI-PROJECT-25291010, KAKENHI-PROJECT-26711002
[Journal Article] DNase II-dependent DNA digestion is required for DNA sensing by TLR92015
- Author(s)
  Chan MP, Onji M, Fukui R, Kawane K, Shibata T, Saitoh SI, Ohto U, Shimizu T, Barber GN, *Miyake K
- Journal Title
  
  Nat Commun
  
  Volume: 6 Issue: 1 Pages: 5853-5853
- DOI
  10.1038/ncomms6853
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25253032, KAKENHI-PROJECT-25460585, KAKENHI-PROJECT-25670189, KAKENHI-PROJECT-26293083, KAKENHI-PROJECT-26670235, KAKENHI-PROJECT-26713011, KAKENHI-PROJECT-25291010
[Journal Article] Structure of human Roquin-2 and its complex with constitutive-decay element RNA.2015
- Author(s)
  Sakurai, S., Ohto, U., & Shimizu, T.
- Journal Title
  
  Acta Crystallogr. Sect. F
  
  Volume: 71 Issue: 8 Pages: 1048-1054
- DOI
  10.1107/s2053230x15011887
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K14471, KAKENHI-PLANNED-23116007, KAKENHI-PROJECT-26711002
[Journal Article] Toll-like receptor 8 senses degradation products of single-stranded RNA.2015
- Author(s)
  Tanji H, Ohto U, Shibata T, Taoka M, Yamauchi Y, Isobe T, Miyake K,
- Journal Title
  
  Nat Struct Mol Biol.
  
  Volume: 22 Issue: 2 Pages: 109-115
- DOI
  10.1038/nsmb.2943
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-25115504, KAKENHI-PUBLICLY-25121709, KAKENHI-PROJECT-25291010, KAKENHI-PROJECT-25650029, KAKENHI-PROJECT-26670235, KAKENHI-PROJECT-26711002, KAKENHI-PROJECT-25253032, KAKENHI-PROJECT-15J12485
[Journal Article] Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9.2015
- Author(s)
  Ohto, U., Shibata, T., Tanji, H., Krayukhina, E., Uchiyama, S., Miyake, K., and Shimizu, T.
- Journal Title
  
  Nature
  
  Volume: 520 Issue: 7549 Pages: 702-705
- DOI
  10.1038/nature14138
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-25121722, KAKENHI-PUBLICLY-26102530, KAKENHI-PROJECT-25253032, KAKENHI-PROJECT-25291010
[Journal Article] Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases2015
- Author(s)
  Kanno A, Tanimura N, Ishizaki M, Ohko K, Motoi Y, Onji M, Fukui R, Shimozato T, Yamamoto K, Shibata T, Sano S, Sugahara-Tobinai A, Takai T, Ohto U, Shimizu T, Saitoh S, Miyake K.
- Journal Title
  
  Nature Communications
  
  Volume: 6 Issue: 1 Pages: 6119-6119
- DOI
  10.1038/ncomms7119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13J40043, KAKENHI-PROJECT-25253032, KAKENHI-PROJECT-25460585, KAKENHI-PROJECT-25670189, KAKENHI-PROJECT-26293083, KAKENHI-PROJECT-26670235, KAKENHI-PROJECT-26461597, KAKENHI-PROJECT-25291010
[Journal Article] Structure and function of toll-like receptor 8.2014
- Author(s)
  Ohto, U., Tanji, H., & Shimizu, T.
- Journal Title
  
  Microbes Infect.
  
  Volume: 16 Issue: 4 Pages: 273-282
- DOI
  10.1016/j.micinf.2014.01.007
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25115504, KAKENHI-PUBLICLY-25121709, KAKENHI-PROJECT-25291010, KAKENHI-PROJECT-25650029
[Journal Article] Determinants of activity at human Toll-like receptors 7 and 8: quantitative structure-activity2014
- Author(s)
  Yoo E, Salunke DB, Sil D, Guo X, Salyer AC, Hermanson AR, Kumar M,
- Journal Title
  
  J Med Chem.
  
  Volume: 57 Issue: 19 Pages: 7955-7970
- DOI
  10.1021/jm500744f
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-25115504, KAKENHI-PUBLICLY-25121709, KAKENHI-PROJECT-25291010, KAKENHI-PROJECT-25650029, KAKENHI-PROJECT-26711002
[Journal Article] Characterisation of an intrinsically disordered protein complex of Swi5-Sfr1 by ion mobility mass spectrometry and small-angle X-ray scattering2013
- Author(s)
  Saikusa K, Kuwabara N, Kokabu Y, Inoue Y, Sato M, Iwasaki H, Shimizu T, Ikeguchi M, Akashi S
- Journal Title
  
  Analyst
  
  Volume: 138 Pages: 1441-1449
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370045
[Journal Article] Mechanistic insights into the activation of Rad51-mediated strand exchange from the structure of a recombination activator, the Swi5-Sfr1 complex2013
- Author(s)
  N.Kuwabara, Y.Murayama, H.Hashimoto, Y.Kokabu, M.Ikeguchi, M.Sato, K.Mayanagi, Y.Tsutsui, H.Iwasaki,and T.Shimizu
- Journal Title
  
  Structure
  
  Volume: 20 Issue: 3 Pages: 440-449
- DOI
  10.1016/j.str.2012.01.005
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21113002, KAKENHI-PROJECT-21370048, KAKENHI-PROJECT-21570114, KAKENHI-PROJECT-22370045, KAKENHI-PROJECT-22770109, KAKENHI-PUBLICLY-23118713, KAKENHI-PUBLICLY-23121524, KAKENHI-PROJECT-23770105, KAKENHI-PROJECT-24247033, KAKENHI-PROJECT-24657076, KAKENHI-PLANNED-22125003, KAKENHI-PUBLICLY-24114506
[Journal Article] Characterisation of an intrinsically disordered protein complex of Swi5-Sfr1 by ion mobility mass spectrometry and small-angle X-ray scattering2013
- Author(s)
  Saikusa K, Kuwabara N, Kokabu Y, Inoue Y, Sato M, Iwasaki H, Shimizu T, Ikeguchi M, Akashi S
- Journal Title
  
  Analys
  
  Volume: 138 Issue: 5 Pages: 1441-14499
- DOI
  10.1039/c2an35878f
- NAID
  120006557136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20227009, KAKENHI-PLANNED-21113002, KAKENHI-PLANNED-21113003, KAKENHI-PLANNED-22125003, KAKENHI-PROJECT-22570120, KAKENHI-PLANNED-23116007, KAKENHI-PROJECT-23770105, KAKENHI-PROJECT-24247033
[Journal Article] Structural basis for vitamin D receptor agonism by novel non-secosteroidal ligands2013
- Author(s)
  Lisa Asano, Ichiaki Ito, Naoyuki Kuwabara, Tsuyoshi Waku, Junn Yanagisawa, Hiroyuki Miyachi, Toshiyuki Shimizu
- Journal Title
  
  FEBS lettters
  
  Volume: 587 Issue: 7 Pages: 957-963
- DOI
  10.1016/j.febslet.2013.02.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J00300, KAKENHI-PROJECT-12J00646, KAKENHI-PLANNED-23116007, KAKENHI-PROJECT-23770105
[Journal Article] Peroxisome proliferator-activated receptors (PPARs) have multiple binding points2012
- Author(s)
  Kuwabara N, Oyama T, Tomioka D, Ohashi M, Yanagisawa J, Shimizu T, Miyachi H.
- Journal Title
  
  J. Med.Chem.
  
  Volume: 55 Issue: 2 Pages: 893-902
- DOI
  10.1021/jm2014293
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590128, KAKENHI-PROJECT-23770105, KAKENHI-PLANNED-23116007
[Journal Article] Crystal Structure of Human β-Galactosidase: The Structural Basis of GM1 Gangliosidosis and Morquio B Diseases2012
- Author(s)
  Ohto U, Usui K, , Ochi T, ,Yuki K, Satow Y andShimizu T
- Journal Title
  
  J. Biol. Chem
  
  Volume: 287 Pages: 1801-1812
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370045
[Journal Article] Mechanistic insights into the activation of rad51-mediated strand exchange from the structure of a recombination activator, the swi5-sfr1 complex2012
- Author(s)
  Kuwabara N, Murayama Y, Hashimoto H, Kokabu Y, Ikeguchi M, Sato M, Mayanagi K, Tsutsui Y, Iwasaki H, Shimizu T
- Journal Title
  
  Structure
  
  Volume: 20 Pages: 440-449
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370045
[Journal Article] The fission yeast Swi5-Sfr1 complex, an activator of Rad51 recombinase, forms an extremely elongated Dogleg-shaped structure2011
- Author(s)
  Kokabu Y, Murayama Y, Kuwabara N, Oroguchi T, Hashimoto H, Tsutsui Y, Nozaki N, Akashi S, Unzai S, Shimizu T, Iwasaki H, Sato M, Ikeguchi M
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Pages: 43569-76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370045
[Journal Article] Crystal Structures of Mouse and Human RP105/MD-1 Complexes Reveal Unique Dimer Organization of the Toll-Like Receptor Family2011
- Author(s)
  Ohto U, Miyake K, Shimizu T
- Journal Title
  
  J Mol Biol
  
  Volume: 413 Pages: 815-825
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370045
[Journal Article] Fission yeast Swi5-Sfr1 protein complex, an activator of Rad51 recombinase, forms an extremely elongated dogleg-shaped structure2011
- Author(s)
  Kokabu Y, Murayama Y, Kuwabara N, Oroguchi T, Hashimoto H, Tsutsui Y, Nozaki N, Akashi S, Unzai S, Shimizu T, Iwasaki H, Sato M, Ikeguchi M
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Issue: 50 Pages: 43569-43576
- DOI
  10.1074/jbc.m111.303339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20227009, KAKENHI-PLANNED-21113002, KAKENHI-PLANNED-21113003, KAKENHI-PROJECT-21370048, KAKENHI-PROJECT-22370045, KAKENHI-PROJECT-22570120, KAKENHI-PROJECT-22770109, KAKENHI-PLANNED-23116007, KAKENHI-PUBLICLY-23118713, KAKENHI-PUBLICLY-23121524, KAKENHI-PROJECT-23570145, KAKENHI-PROJECT-23770105
[Journal Article] The structure of the N-terminal regulatory domain of a plant NADPH oxidase and its functional implications2010
- Author(s)
  Kuwabara, N., Hashimoto, H., Yamada, N., Unzai, S., Ikeguchi, M., Sato, M., Murayama, Y., Iwasaki, H. and Shimizu, T.
- Journal Title
  
  Acta Crystallogr
  
  Volume: F66 Pages: 1124-1126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370045
[Journal Article] Expression, Purification and crystallization of Swi5 and the Swi5-Sfr1 complex from fission yeast2010
- Author(s)
  Kokabu Y, Murayama Y, Kuwabara N, Oroguchi T, Hashimoto H, Tsutsui Y, Nozaki N, Akashi S, Unzai S, Shimizu T, Iwasaki H, Sato M, Ikeguchi M
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Pages: 43569-76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370045
[Journal Article] 創薬を指向した関節リウマチ関連遺伝子PAD4の構造科学研究2007
- Author(s)
  清水
- Journal Title
  
  Pharma VISION NEWS 9
  
  Pages: 21-23
- Data Source
  KAKENHI-PROJECT-18055027
[Journal Article] X線結晶構造解析?タンパク質の結晶構造解析?2007
- Author(s)
  清水
- Journal Title
  
  実験医学(生命科学のための機器分析実験ハンドブック)
  
  Pages: 198-202
- Data Source
  KAKENHI-PROJECT-18055027
[Journal Article] Parallel coiled-coil association of the RhoA-binding domain in Rho-kinase2003
- Author(s)
  Shimizu, T., et. al.
- Journal Title
  
  J.Biol.Chem 278
  
  Pages: 46046-46051
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570101
[Journal Article] Parallel coiled-coil association of the RhoA-binding domain in Rho-kinase2003
- Author(s)
  Shimizu, et. al.
- Journal Title
  
  J. Biol. Chem 278
  
  Pages: 46046-46051
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15570101
[Journal Article]
- Author(s)
  Oda, T., Hashimoto, H., Kuwabara, N., Akashi, S., Hayashi, K., Kojima, C., Wong, H.L., Kawasaki, T., Shimamoto, K., Sato, M., and Shimizu, T
- Journal Title
  
  J.Biol.Chem
  
  Volume: 285 Pages: 1435-1445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370045
[Patent] カルシニューリンサブユニットB様蛋白質の結晶その製造方法、探索方法2003
- Inventor(s)
  清水敏之
- Industrial Property Rights Holder
  横浜市
- Industrial Property Number
  2003-305216
- Filing Date
  2003-09-01
- Data Source
  KAKENHI-PROJECT-15570101
[Presentation] 病原体感染を感知するToll様受容体の構造基盤2018
- Author(s)
  清水敏之
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16H02494
[Presentation] 構造解析から見えた自然免疫における一本鎖核酸認識 Toll様受容体の共通性およびその創薬への展開2018
- Author(s)
  清水敏之
- Organizer
  ゲノム創薬・医療フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-16H02494
[Presentation] Structural study of ssRNA sensing TLRs in innate immune system2017
- Author(s)
  Toshiyuki Shimizu
- Organizer
  24th Congress and General Assembly of the International Union of Crystallography
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02494
[Presentation] Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 92016
- Author(s)
  Toshiyuki Shimizu
- Organizer
  12th Annual Meeting of the Oligonucleotide Therapeutics Society
- Place of Presentation
  Centre Mont-Royal (Montreal, Canada)
- Year and Date
  2016-09-25
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02494
[Presentation] Structural study of TLRs sensing single stranded RNA in innate immune system2016
- Author(s)
  Toshiyuki Shimizu
- Organizer
  Naito Conference
- Place of Presentation
  Chateraise Gateaux Kingdom Sapporo（北海道、札幌市）
- Year and Date
  2016-10-04
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02494
[Presentation] hPRMT8の結晶-溶液構造相関解析をもとにした機能解明2015
- Author(s)
  藤間祥子、Kim, JD.、Park, KE.、清水伸隆、桑原直之、Krayukhina, E.、内山進、深水昭吉、清水敏之
- Organizer
  日本結晶学会年会
- Place of Presentation
  大阪府堺市　大阪府立大学中百舌鳥キャンパス、103講義室
- Year and Date
  2015-10-18
- Data Source
  KAKENHI-ORGANIZER-23116001
[Presentation] Structural studies of single-stranded RNA receptor TLR82015
- Author(s)
  Hiromi Tanji, Umeharu Ohto, Takuma Shibata, Kensuke Miyake, Toshiyuki Shimizu
- Organizer
  Toll meeting 2015
- Place of Presentation
  Palacio de Congresos de Mabella(SPAIN)
- Year and Date
  2015-10-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25291010
[Presentation] 自然免疫系一本鎖RNA受容体TLR8の構造基盤2015
- Author(s)
  丹治裕美、大戸梅治、柴田琢磨、田岡万悟、山内芳雄、礒邉俊明、三宅健介、清水敏之
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  あわぎんホール（徳島県徳島市）
- Year and Date
  2015-06-25
- Data Source
  KAKENHI-PROJECT-25291010
[Presentation] Toll 様受容体 8(TLR8)の構造科学的研究2013
- Author(s)
  清水敏之
- Organizer
  日本生化学大会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Data Source
  KAKENHI-PROJECT-25291010
[Presentation] 創薬を指向した構造生物学の最前線（オーガナイザー）2013
- Author(s)
  清水敏之
- Organizer
  日本薬学会第１３３年会シンポジウム
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-ORGANIZER-23116001
[Presentation] Structural basis for vitamin D receptor antagonistic mechanism by 1α, 25-dihydroxyvitamin D3-26, 23-lactams (DLAMs)2013
- Author(s)
  浅野理沙、伊藤一明、和久剛、長澤和夫、柳澤純、清水敏之
- Organizer
  ICSG2013-SLS
- Place of Presentation
  北海道　京王プラザホテル
- Data Source
  KAKENHI-ORGANIZER-23116001
[Presentation] Structural basis for vitamin D receptor antagonistic mechanism by 1α, 25-dihydroxyvitamin D3-26, 23-lactams (DLAMs)2013
- Author(s)
  Asano L, Ito I, Waku T, Nagasawa K, Yanagisawa J, Shimizu T
- Organizer
  ICSG2013-SLS
- Place of Presentation
  札幌（北海道）
- Data Source
  KAKENHI-PLANNED-23116007
[Presentation] Structural study of recombination activator, Swi5-Sfr1 complex2012
- Author(s)
  Shimizu T
- Organizer
  New frontier of the research in RecAfamily recombinases and their accessory proteins (RecA family 2012)
- Place of Presentation
  Kyoto Royal Hotel & Spa, Kyoto, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-22370045
[Presentation] Structural basis for vitamin D receptor agonism by novel nonsecosteroidal ligands2012
- Author(s)
  Lisa Asano, Ichiaki Ito, Naoyuki Kuwabara, Junn Yanagisawa, Hiroyuki Miyachi, Toshiyuki Shimizu
- Organizer
  AsCA 12
- Place of Presentation
  オーストラリアアデレード
- Data Source
  KAKENHI-PROJECT-23770105
[Presentation] New frontier of the research in RecAfamily recombinases and their accessory proteins (RecA family 2012)2012
- Author(s)
  Toshiyuki Shimizu
- Organizer
  Structural study of recombination activator, Swi5-Sfr1 complex
- Place of Presentation
  Kyoto Royal Hotel & Spa, Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-22370045
[Presentation] 自然免疫系受容体TLR4とその関連タンパク質の構造生物学的研究2012
- Author(s)
  Shimizu T
- Organizer
  第22回ＷＳフォーラム
- Place of Presentation
  九州大学
- Year and Date
  2012-11-17
- Invited
- Data Source
  KAKENHI-PLANNED-23116007
[Presentation] Program for Young Researcher Symposium inEurope'SGC Oxford2012
- Author(s)
  Toshiyuki Shimizu
- Organizer
  Mechanistic insights into the activation of the Rad51-mediated strand exchange from the structure of recombination activator, Swi5-Sfr1 complex
- Place of Presentation
  Oxford, UK
- Year and Date
  2012-06-08
- Data Source
  KAKENHI-PROJECT-22370045
[Presentation] Mechanistic insights into the activation of the Rad51-mediated strand exchange from the structure of a recombination activator, the Swi5-Sfr1 complex2011
- Author(s)
  Toshiyuki Shimizu
- Organizer
  Symposium on Structure and Folding of Disease Related Proteins
- Place of Presentation
  ソウル大学、韓国
- Year and Date
  2011-07-08
- Data Source
  KAKENHI-PUBLICLY-23121508
[Presentation] Symposium on Structure and Folding of Disease Related Proteins2011
- Author(s)
  Toshiyuki Shimizu
- Organizer
  Mechanistic insights into the activation of the Rad51-mediated strand exchange from the structure of a recombination activator, the Swi5-Sfr1 complex
- Place of Presentation
  Seoul National University, Korea
- Year and Date
  2011-07-08
- Data Source
  KAKENHI-PROJECT-22370045
[Presentation] Structural analysis of Swi5-Sfr1 complex, mediators for homologous recombination2011
- Author(s)
  Naoyuki Kuwabara, Hiroshi Hashimoto, Yuichi Kokabu, Mitsunori Ikeguchi, Mamoru Sato, Kouta Mayanagi, Yasuto Murayama, Hiroshi Iwasaki, Toshiyuki Shimizu
- Organizer
  第11回日本蛋白質科学会年会
- Place of Presentation
  大阪府
- Year and Date
  2011-06-08
- Data Source
  KAKENHI-PROJECT-23770105
[Presentation] Mechanistic insights into the activation of the Rad51-mediated strand exchange from the structure of a recombination activator, the Swi5-Sfr1 comple2011
- Author(s)
  Shimizu T
- Organizer
  Symposium on Structure and Folding of Disease Related Proteins
- Place of Presentation
  Seoul National University, Korea(招待講演)
- Year and Date
  2011-07-08
- Data Source
  KAKENHI-PROJECT-22370045
[Presentation] New frontier of the research in Rad51 recombinase and its accessory proteinsInstitut de Biologie Physico Chimique2011
- Author(s)
  Toshiyuki Shimizu
- Organizer
  Crystal structure of recombination activator, Swi5-Sfr1 complex, from fission yeast
- Place of Presentation
  France
- Data Source
  KAKENHI-PROJECT-22370045
[Presentation] Strucutual analysis of Swi5-Sfr1 complex, mediators for homologous recombination.2011
- Author(s)
  N. Kuwabara, H. Hashimoto, Y. Kokabu, M. Ikeguchi, M. Sato, K. Mayanagi, Y. Murayama, H. Iwasaki, T. Shimizu
- Organizer
  第１１回日本蛋白質科学会年会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23770105
[Presentation] 代謝とクロストークする転写環境形成因子の構造科学的な解明2011
- Author(s)
  清水敏之
- Organizer
  Wakoつくばフォーラム
- Place of Presentation
  筑波和光ホール(招待講演)
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PLANNED-23116007
[Presentation] 細胞質から核内へのタンパク質輸送機構-核内輸送受容体(トランスポーチン)の構造生物学-2010
- Author(s)
  清水敏之
- Organizer
  九州大学研究拠点形成プロジェクトP&P
- Place of Presentation
  九州大学
- Year and Date
  2010-01-28
- Data Source
  KAKENHI-PUBLICLY-21117513
[Presentation] 関節リウマチ関連タンパク質PAD4の構造科学的研究2010
- Author(s)
  清水敏之
- Organizer
  構造生物社会連携シンポジウム
- Place of Presentation
  東京大学
- Year and Date
  2010-11-20
- Data Source
  KAKENHI-PROJECT-22370045
[Presentation] Structural Studies of Chromatin-related Proteins PAD4 and NML Recognizing Intrinsically Disordered Region2009
- Author(s)
  Shimizu T
- Organizer
  Yokohama NMR workshop
- Place of Presentation
  Yokohama
- Year and Date
  2009-11-12
- Data Source
  KAKENHI-PROJECT-20052023
[Presentation] Structural Studies of Chromatin-related Proteins PAD4 and NML Recognizing Intrinsically Disordered Region2009
- Author(s)
  Shimizu T
- Organizer
  Yokohama NMR workshop
- Place of Presentation
  Yokohama
- Year and Date
  2009-11-12
- Data Source
  KAKENHI-PUBLICLY-21117513
[Presentation] Structural study of rheumatoid arthritis related protein, PAD42008
- Author(s)
  Shimizu
- Organizer
  International Forum co-sponsored by YCU & FDA
- Place of Presentation
  Yokohama
- Year and Date
  2008-01-30
- Data Source
  KAKENHI-PROJECT-20052023
[Presentation] シロイヌナズナ由来AtCBL2とAtCIPK14の複合体構造2007
- Author(s)
  清水, et. al.
- Organizer
  日本蛋白質科学会
- Place of Presentation
  仙台国際センター
- Data Source
  KAKENHI-PROJECT-18055027
[Presentation] 線虫由来タンパク質アルギニンメチル基転移酵素7 の結晶構造解析
- Author(s)
  長谷川森雄,藤間‐深井祥子,金俊達,深水昭吉,清水敏之
- Organizer
  日本結晶学会
- Place of Presentation
  東京都文京区　東京大学
- Year and Date
  2014-11-01 – 2014-11-03
- Data Source
  KAKENHI-ORGANIZER-23116001
[Presentation] Mechanistic insights into the activation of the Rad51-mediated strand exchange from the structure of recombination activator, Swi5-Sfr1 complex
- Author(s)
  Shimizu T
- Organizer
  Program for Young Researcher Symposium in Europe
- Place of Presentation
  Oxford, UK
- Invited
- Data Source
  KAKENHI-PROJECT-22370045
[Presentation] Structural study of innate immune receptor, TLR
- Author(s)
  Shimizu T
- Organizer
  FAOBMB Mini-Symposium 2013
- Place of Presentation
  岩手医科大学（岩手県）
- Invited
- Data Source
  KAKENHI-PROJECT-25291010
[Presentation] Structural study of TLR8 sensing single stranded RNA in innate immune system
- Author(s)
  Shimizu T
- Organizer
  The 4th Asia Pacific Protein Association (APPA) Conference
- Place of Presentation
  Jeju, Korea
- Year and Date
  2014-05-17 – 2014-05-20
- Data Source
  KAKENHI-PROJECT-25291010
[Presentation] Structural study of TLR8 sensing single stranded RNA in innate immune system
- Author(s)
  Shimizu T
- Organizer
  The Cold Spring Harbor Asia conference
- Place of Presentation
  Suzhou Dushu Lake Conference Center, Suzhou, China
- Year and Date
  2014-10-27 – 2014-10-31
- Invited
- Data Source
  KAKENHI-PROJECT-25291010

1. HAKOSHIMA Toshio (00164773)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
2. OKADA Kengo (60304169)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. SATO Mamoru (60170784)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. 柴田琢磨 (30554505)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TOMA Sachiko (40363535)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NAKAJIMA Yuka (40399499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. KUWABARA Naoyuki (70506253)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. IKEGUCHI Mitsunori (60261955)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. IWASAKI Hiroshi (60232659)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. HASHIMOTO Hiroshi (40336590)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. FUKAMIZU Akiyoshi (60199172)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. IGARASHI Kazuhiko (00250738)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. NAKAO Mitsuyoshi (00217663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SUGASAWA Kaoru (70202124)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. MOTOHASHI Hozumi (00282351)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. YAHAGI Naoya (60420246)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 北野健 (40346309)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 三宅健介 (60229812)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
19. 淺原弘嗣 (70294460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 田岡万悟 (60271160)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 川崎努 (90283936)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 清水元樹 (90734343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. HIGASHI Tsuneyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. SASAKI Hiroyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. YONEDA Yoshihiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. KASUGA Masato

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. OHTO Umeharu

# of Collaborated Projects: 0 results

# of Collaborated Products: 15 results
28. 斉藤伸一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
29. 宮地弘幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 張志寛

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
31. 金俊達

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 明石知子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
33. 内山進

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 川口寧

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shimizu Toshiyuki 清水 敏之

SHIMIZU Toshiyuki 清水 敏之

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Lysosomes as the starting point of innate immune responses - importance of lysosomal environment -Principal Investigator

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Overcoming the problems in CryoEM analysis using sugar chain and its application to the innate immune receptor, TLRPrincipal Investigator

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Elucidation of molecular motion and new regulation mechanisms in innate immune sensorsPrincipal Investigator

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Structural basis of proteins related with innate immunityPrincipal Investigator

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Structural studies of nucleic acid sensing Toll-like receptorsPrincipal Investigator

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Structural analysis of the transcription environment factors that engage in crosstalk with metabolic pathwaysPrincipal Investigator

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リコンビナーゼとその活性化因子との複合体構造を通した鎖交換反応の構造基盤の確立Principal Investigator

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Structural studies of a novel mediator regulating homologous recombinationPrincipal Investigator

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植物自然免疫を担う活性酸素生成酵素の制御機構の構造生物学的解明Principal Investigator

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メチル基転移領域を有する新規核小体蛋白質とその複合体の構造基盤の確立Principal Investigator

Shimizu Toshiyuki 清水敏之

SHIMIZU Toshiyuki 清水敏之