Takenaka Katsuto 竹中克斗

… Alternative Names

TAKENAKA Katsuto 竹中克斗

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Researcher Number	30301295
Other IDs
Affiliation (Current)	2025: 愛媛大学, 医学系研究科, 教授
Affiliation (based on the past Project Information) *help	2018 – 2024: 愛媛大学, 医学系研究科, 教授 2012 – 2017: 九州大学, 大学病院, 講師 2015: 九州大学病院, 遺伝子細胞療法部, 講師 2011: 九州大学, 医学(系)研究科(研究院), 助教 2007 – 2011: Kyushu University, Hospital, Assistant Professor … More 2007: Kyushu University, Faculty of Medicine, Visiting researcher 2006: 九州大学, 大学病院, 助手 1998 – 2000: 岡山大学, 医学部・附属病院, 助手 1998: Okayama University, Medical School Hospital, Assistant, 医学部附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Hematology Except Principal Investigator Hematology / Hematology / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / Biological Sciences
Keywords	Principal Investigator 免疫不全マウス / SIRPA / がん幹細胞 / ヒト疾患モデル / 患者組織移植モデル / マクロファージ寛容 / 患者腫瘍組織移植モデル / 異種移植モデル / 骨髄異形成症候群 / 免疫腫瘍学 … More / 幹細胞アッセイシステム / Kit変異 / 骨髄増殖性腫瘍 / 幹細胞 / 異種移植アッセイ / 転写因子 / miRNA / 遺伝子プロファイル / 造血幹細胞 / 白血病幹細胞 … More Except Principal Investigator IL-10 / 白血病幹細胞 / 造血幹細胞 / 同種末梢血幹細胞移植 / G-CSF / UG3 / MCP-1 / 単球 / IL-4 / GVHD / homing / TIM-3 / 免疫不全マウス / がん幹細胞 / 骨髄異形成症候群 / 骨髄増殖性腫瘍 / 急性GVHD / キメラ抗原受容体T細胞 / 腫瘍免疫微小環境 / CAR-T療法 / CAR-T / 免疫微小環境 / CAF / CAR-T細胞療法 / 抑制性腫瘍免疫微小環境 / 癌関連線維芽細胞(CAF) / 膵癌 / 癌微小環境 / 血液学 / 幹細胞 / AML / 微小環境 / エピゲノム / 代謝 / 自己複製能力 / 骨髄系腫瘍 / シグナル / アミノ酸代謝 / メタボローム / 微小残存病変 / メタボロミクス / 治療抵抗性残存白血病 / transgenic mouse / accelerated phase / myelofibrosis / human T cell leukemia / chronic myelocytic leukemia / 原発性骨髄線維症 / トランスジェニックマウス / 急性転化 / 骨髄線維症 / 成人T細胞性白血病 / 慢性骨髄性白血病 / LPS (endotoxin) / ODF (RANKL) / osteoclasts / macrophages / Monocytes / osteoclast differentiation factor / M-CSF / IL-13 / MCP1 / LPS(endotoxin) / IL_10 / LPS(endotoxoin) / ODF(RANKL) / 破骨細胞 / マクロファージ / Natural killer cell / T cell modulation / Mobilization / Cytokine / Peripheral blood stem cell / Hematopoietic stem cell / インターフェロンγ / TNF-α / CD34 / 末梢血幹細胞移植 / CFU-GM / IFN-γ / VLA-4 / NK細胞 / T細胞機能修飾 / 動員 / サイトカイン / 末梢血幹細胞 / C57BL mouse / colony-forming unit / donor / cell transplantation / transplantation / progenitor cells / 骨髄内皮細胞 / 接着因子 / コロニー / ホ-ミング / Colony Farming Unit / ホーミング / C57 BL mouse / Colory Forming Unit / ドナー / 同種骨髄移植 / 分子標的治療 / 癌幹細胞 / CD47 / SIRPA / マクロファージ寛容 / 異種移植 / 腫瘍性幹細胞 / 細胞障害性T細胞 / マイナー組織適合抗原 / 骨髄非破壊的幹細胞移植 / 自己末梢血幹細胞移植 / 移植片対白血病(GVL)効果 / 移植片対腫瘍(GVT)効果 / 進行肺癌 / ドナーリンパ球輸注 / VNTR / 抹消血幹細胞採取 / 移植前治療 / 同種抹消血幹細胞移植 / 高年者白血病 Less

免疫腫瘍学分野における次世代ヒト化患者腫瘍組織移植モデルプラットフォームの樹立Principal Investigator
- Principal Investigator
  
  竹中克斗
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Ehime University
膵癌に対する抗腫瘍免疫抑制性環境の改変を目指したCAR-T療法の開発
- Principal Investigator
  
  中村雅史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Kyushu University
Development of next-generation patient-derived xenograft models for precision medicinePrincipal Investigator
- Principal Investigator
  
  Takenaka Katsuto
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Ehime University
Cancer stem cell purification and drug discovery support by the overall disease model using a new PDX modelPrincipal Investigator
- Principal Investigator
  
  Takenaka Katsuto
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Ehime University
Elucidation of molecular machineries for the regulation of myeloid leukemia stem cells
- Principal Investigator
  
  AKASHI KOICHI
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Hematology
- Research Institution
  Kyushu University
ヒト骨髄性白血病における「静と動」の幹細胞維持・進展メカニズム
- Principal Investigator
  
  赤司浩一
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Hematology
- Research Institution
  Kyushu University
Targeting cancer stem cells in chronic myeloid neoplasmsPrincipal Investigator
- Principal Investigator
  
  TAKENAKA KATSUTO
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kyushu University
Establishment of the myeloid leukemic stem cell-targeted therapy
- Principal Investigator
  
  Akashi Koichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Hematology
- Research Institution
  Kyushu University
Targeting cancer stem cells in myelodysplastic syndromePrincipal Investigator
- Principal Investigator
  
  TAKENAKA Katsuto
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kyushu University
Characterization of tumorigenic stem cells in myeloid neoplasms
- Principal Investigator
  
  AKASHI Koichi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Hematology
- Research Institution
  Kyushu University
Functional analysis of miRNA/transcription factors highly expressed in leukemia stem cellsPrincipal Investigator
- Principal Investigator
  
  TAKENAKA Katsuto
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kyushu University
Developmental mechanisms of hematological malignancies revealed by humanized mouse models.
- Principal Investigator
  
  HARADA Mine
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Kyushu University
進行肺癌に対する同種末梢血幹細胞移植:移植片対腫瘍効果とCTLの誘導
- Principal Investigator
  
  原田実根
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Okayama University
STUDY ON DIFFERENTIATION MECHANISM OF MACROPHAGES, STEOCLASTS AND DENDRITIC CELLS FROM MONOCYTIC PRECURSORS
- Principal Investigator
  
  IKEDA Kazuma
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  OKAYAMA UNIVERSITY
高年者白血病に対する同種抹消血幹細胞移植に関する基礎的臨床的研究
- Principal Investigator
  
  HARADA Mine
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Okayama University
G-CSF-induced mobilization of peripheral blood stem cells trans-plantation and analysis of G-CSF-primed immunocompetent cells
- Principal Investigator
  
  HARADA Mine
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Hematology
- Research Institution
  OKAYAMA UNIVERSITY
Mcchanisms of homing for hematopoietic progenitor cells after bone marrow transplantation
- Principal Investigator
  
  SHINAGAWA Katsuji
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Okayama University

[Journal Article] Reinforced antimyeloma therapy via dual-lymphoid activation mediated by a panel of antibodies armed with bridging-BiTE2023
- Author(s)
  Konishi Tatsuya、Ochi Toshiki、Maruta Masaki、Tanimoto Kazushi、Miyazaki Yukihiro、Iwamoto Chika、Saitou Takashi、Imamura Takeshi、Yasukawa Masaki、Takenaka Katsuto
- Journal Title
  
  Blood
  
  Volume: 142 Issue: 21 Pages: 1789-1805
- DOI
  10.1182/blood.2022019082
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08462, KAKENHI-PROJECT-21K15569, KAKENHI-PROJECT-21H02949
[Journal Article] Real-world clinical characteristics of post-essential thrombocythemia and post-polycythemia vera myelofibrosis2023
- Author(s)
  Shide K, Takenaka K, Kitanaka A, Numata A, Kameda T, Yamauchi T, Inagaki A, Mizuno S, Takami A, Ito S, Hagihara M, Usuki K, Maekawa T, Sunami K, Ueda Y, Tsutsui M, Ando M, Komatsu N, Ozawa K, Kurokawa M, Arai S, Mitani K, Akashi K, Shimoda K
- Journal Title
  
  Annals of Hematology
  
  Volume: 103 Issue: 1 Pages: 97-103
- DOI
  10.1007/s00277-023-05528-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07488, KAKENHI-PROJECT-23K07817, KAKENHI-PROJECT-21K15579, KAKENHI-PROJECT-21H02949, KAKENHI-PROJECT-23K27629
[Journal Article] Outcomes of allogeneic hematopoietic cell transplantation under letermovir prophylaxis for cytomegalovirus infection2023
- Author(s)
  Takenaka Katsuto、Fuji Shigeo、Matsukawa Toshihiro、et al.
- Journal Title
  
  Annals of Hematology
  
  Volume: 103 Issue: 1 Pages: 285-296
- DOI
  10.1007/s00277-023-05474-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02949
[Journal Article] Long-term transition of antibody titers in healthcare workers following the first to fourth doses of mRNA COVID-19 vaccine: Comparison of two automated SARS-CoV-2 immunoassays2023
- Author(s)
  Taniguchi Yumi、Suemori Koichiro、Tanaka Keiko、Okamoto Ai、Murakami Akiko、Miyamoto Hitoshi、Takasuka Yasunori、Yamashita Masakatsu、Takenaka Katsuto
- Journal Title
  
  Journal of Infection and Chemotherapy
  
  Volume: 29 Issue: 5 Pages: 534-538
- DOI
  10.1016/j.jiac.2023.01.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02949
[Journal Article] Nationwide prospective survey of secondary myelofibrosis in Japan: superiority of DIPSS-plus to MYSEC-PM as a survival risk model2023
- Author(s)
  Shide K, Takenaka K, Kitanaka A, Numata A, Kameda T, Yamauchi T, Inagaki A, Mizuno S, Takami A, Ito S, Hagihara M, Usuki K, Maekawa T, Sunami K, Ueda Y, Tsutsui M, Ando M, Komatsu N, Ozawa K, Kurokawa M, Arai S, Mitani K, Akashi K, Shimoda K
- Journal Title
  
  Blood Cancer Journal
  
  Volume: 13 Issue: 1 Pages: 110-110
- DOI
  10.1038/s41408-023-00869-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07488, KAKENHI-PROJECT-23K07817, KAKENHI-PROJECT-21K08427, KAKENHI-PROJECT-21K15579, KAKENHI-PROJECT-21H02949, KAKENHI-PROJECT-23K27629
[Journal Article] Prognostic impact of complex karyotype on post-transplant outcomes of myelofibrosis.2022
- Author(s)
  Okada Y, Takenaka K, Murata M, Shimazu Y, Tachibana T, Ozawa Y, Uchida N, Wakayama T, Doki N, Sugio Y, Tanaka M, Masuko M, Kobayashi H, Ino K, Ishikawa J, Nakamae H, Matsuoka KI, Kanda Y, Fukuda T, Atsuta Y, Nagamura-Inoue T.
- Journal Title
  
  Hematol Oncol
  
  Volume: 40 Issue: 5 Pages: 1076-1085
- DOI
  10.1002/hon.3058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08387, KAKENHI-PROJECT-21H02949
[Journal Article] Epigenetic regulator UHRF1 orchestrates proinflammatory gene expression in rheumatoid arthritis in a suppressive manner2022
- Author(s)
  Saeki Noritaka、Inoue Kazuki、Ideta-Otsuka Maky、Watamori Kunihiko、Mizuki Shinichi、Takenaka Katsuto、Igarashi Katsuhide、Miura Hiromasa、Takeda Shu、Imai Yuuki
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 132 Issue: 11
- DOI
  10.1172/jci150533
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05974, KAKENHI-PROJECT-21H02949, KAKENHI-PROJECT-23K24462, KAKENHI-PROJECT-21H03604
[Journal Article] Two-Year Seroprevalence Surveys of SARS-CoV-2 Antibodies among Outpatients and Healthcare Workers in Ehime, Japan2022
- Author(s)
  Suemori Koichiro、Taniguchi Yumi、Okamoto Ai、Murakami Akiko、Ochi Fumihiro、Aono Harutaka、Hato Naohito、Osawa Haruhiko、Miyamoto Hitoshi、Sugiyama Takashi、Yamashita Masakatsu、Tauchi Hisamichi、Takenaka Katsuto
- Journal Title
  
  Jpn J Infect Dis
  
  Volume: 75 Issue: 5 Pages: 523-526
- DOI
  10.7883/yoken.JJID.2022.155
- ISSN
  1344-6304, 1884-2836
- Year and Date
  2022-09-30
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02949
[Journal Article] Risk factors for late cytomegalovirus infection after completing letermovir prophylaxis2022
- Author(s)
  Mori Yasuo、Harada Takuya、Yoshimoto Goichi、Shima Takahiro、Numata Akihiko、Jinnouchi Fumiaki、Yamauchi Takuji、Kikushige Yoshikane、Kunisaki Yuya、Kato Koji、Takenaka Katsuto、Akashi Koichi、Miyamoto Toshihiro
- Journal Title
  
  International Journal of Hematology
  
  Volume: 116 Issue: 2 Pages: 258-265
- DOI
  10.1007/s12185-022-03348-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H04827, KAKENHI-PROJECT-21H02949, KAKENHI-PROJECT-21H02950, KAKENHI-PROJECT-23K24364
[Journal Article] Selective targeting of multiple myeloma cells with a monoclonal antibody recognizing the ubiquitous protein CD98 heavy chain2022
- Author(s)
  Hasegawa Kana et al.
- Journal Title
  
  Science Translational Medicine
  
  Volume: 14 Issue: 632 Pages: 7706-7706
- DOI
  10.1126/scitranslmed.aax7706
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05282, KAKENHI-PROJECT-20H00455, KAKENHI-PROJECT-19H03407, KAKENHI-PROJECT-21H02949, KAKENHI-PROJECT-21K15487, KAKENHI-PROJECT-19H05648, KAKENHI-PROJECT-21H03365, KAKENHI-PLANNED-18H05463, KAKENHI-PROJECT-23K24228
[Journal Article] Correction to: Efficacy and safety of ropeginterferon alfa-2b in Japanese patients with polycythemia vera: an open-label, single-arm, phase 2 study2022
- Author(s)
  Edahiro Yoko、Ohishi Kohshi、Gotoh Akihiko、Takenaka Katsuto、Shibayama Hirohiko、Shimizu Takayuki、Usuki Kensuke、Shimoda Kazuya、Ito Masafumi、VanWart Scott A.、Zagrijtschuk Oleh、Qin Albert、Kawase Hiroaki、Miyachi Narihisa、Sato Toshiaki、Komatsu Norio、Kirito Keita
- Journal Title
  
  International Journal of Hematology
  
  Volume: 116 Issue: 4 Pages: 642-643
- DOI
  10.1007/s12185-022-03440-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02949
[Journal Article] Hematopoietic stem progenitor cells with malignancy‐related gene mutations in patients with acquired aplastic anemia are characterized by the increased expression of CXCR42022
- Author(s)
  Katagiri Takamasa,Espinoza Luis,Uemori Mizuho,Ikeda Honoka,Hosokawa Kohei,Ishiyama Ken,Yoroidaka Takeshi,Imi Tatsuya,Takamatsu Hiroyuki,Ozawa Tatsuhiko,Kishi Hiroyuki,Yamamoto Yasuhiko,Elbadry Mahmoud,Yoshida Yoshinori,Chonabayashi Kazuhisa,Takenaka Katsuto,Akashi Koichi,Nannya Yasuhito,Ogawa Seishi,Nakao Shinji
- Journal Title
  
  eJHaem
  
  Volume: 3 Issue: 3 Pages: 669-680
- DOI
  10.1002/jha2.515
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08367, KAKENHI-PROJECT-21H02695, KAKENHI-PROJECT-21H02949, KAKENHI-PROJECT-20K08707
[Journal Article] Clinical characteristics of Japanese patients with polycythemia vera: results of the JSH-MPN-R18 study2022
- Author(s)
  Edahiro Yoko、Tomita Akihiro、et al.
- Journal Title
  
  International Journal of Hematology
  
  Volume: 116 Issue: 5 Pages: 696-711
- DOI
  10.1007/s12185-022-03412-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08407, KAKENHI-PROJECT-20H03713, KAKENHI-PROJECT-21H02949
[Journal Article] CD21lo B Cells Could Be a Potential Predictor of Immune-Related Adverse Events in Renal Cell Carcinoma.2022
- Author(s)
  Nishimura K, Konishi T, Ochi T, Watanabe R, Noda T, Fukumoto T, Miura N, Miyauchi Y, Kikugawa T, Takenaka K, Saika T.
- Journal Title
  
  J Pers Med.
  
  Volume: 12 Issue: 6 Pages: 888-894
- DOI
  10.3390/jpm12060888
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09373, KAKENHI-PROJECT-21H02949
[Journal Article] Efficacy and safety of ropeginterferon alfa-2b in Japanese patients with polycythemia vera: an open-label, single-arm, phase 2 study.2022
- Author(s)
  Edahiro Y, Ohishi K, Gotoh A, Takenaka K, Shibayama H, Shimizu T, Usuki K, Shimoda K, Ito M, VanWart SA, Zagrijtschuk O, Qin A, Kawase H, Miyachi N, Sato T, Komatsu N, Kirito K.
- Journal Title
  
  Int J Hematol
  
  Volume: ー Issue: 2 Pages: 215-227
- DOI
  10.1007/s12185-022-03341-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08861, KAKENHI-PROJECT-20H03713, KAKENHI-PROJECT-21H02949
[Journal Article] Negative Impact of Cytomegalovirus Reactivation on Survival in Adult Patients with Aplastic Anemia after an Allogeneic Hematopoietic Stem Cell Transplantation: A Report from Transplantation-Related Complication and Adult Aplastic Anemia Working Groups of the Japan Society for Hematopoietic Cell Transplantation2021
- Author(s)
  Takenaka Katsuto、Onishi Yasushi、Mori Takehiko、Hirakawa Tsuneaki、Tada Yuuma、Uchida Naoyuki、Kobayashi Takeshi、Kanda Yoshinobu、Ozawa Yukiyasu、Ota Shuichi、Iida Hiroatsu、Fukushima Kentaro、Kimua Takafumi、Fukuda Takahiro、Atsuta Yoshiko、Matsuto Keitaro、Yamazaki Hirohito、Nakasone Hideki
- Journal Title
  
  Transplantation and Cellular Therapy
  
  Volume: 27 Issue: 1 Pages: 82.e1-82.e8
- DOI
  10.1016/j.bbmt.2020.10.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02840, KAKENHI-PROJECT-21H02949
[Journal Article] A single-chain antibody generation system yielding CAR-T cells with superior antitumor function2021
- Author(s)
  Ochi Toshiki、Maruta Masaki、Tanimoto Kazushi、Kondo Fumitake、Yamamoto Toshihiro、Kurata Mie、Fujiwara Hiroshi、Masumoto Junya、Takenaka Katsuto、Yasukawa Masaki
- Journal Title
  
  Communications Biology
  
  Volume: 4 Issue: 1 Pages: 273-273
- DOI
  10.1038/s42003-021-01791-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07376, KAKENHI-PROJECT-18H02839, KAKENHI-PROJECT-20H03719, KAKENHI-PROJECT-18K08361, KAKENHI-PROJECT-21H02949, KAKENHI-PROJECT-21K15569
[Journal Article] Incidence of refractory cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation2021
- Author(s)
  Jinnouchi Fumiaki、Mori Yasuo、Yoshimoto Goichi、Yamauchi Takuji、Nunomura Takuya、Yurino Ayano、Hayashi Masayasu、Yuda Junichiro、Shima Takahiro、Odawara Jun、Takashima Shuichiro、Kamezaki Kenjiro、Kato Koji、Miyamoto Toshihiro、Akashi Koichi、Takenaka Katsuto
- Journal Title
  
  International Journal of Hematology
  
  Volume: 115 Issue: 1 Pages: 96-106
- DOI
  10.1007/s12185-021-03218-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H04827, KAKENHI-PROJECT-21H02949, KAKENHI-PROJECT-21K20885
[Journal Article] Clinical characteristics, prognostic factors, and outcomes of patients with essential thrombocythemia in Japan: the JSH-MPN-R18 study2021
- Author(s)
  Hashimoto Y, Ito T, Gotoh A, Nakamae M, Kimura F, Koike M, Kirito K, Wada H, Usuki K, Tanaka T, Mori T, Wakita S, Saito TI, Kada A, Saito AM, Shimoda K, Sugimoto Y, Kurokawa T, Tomita A, Edahiro Y, Akashi K, Matsumura I, Takenaka K, Komatsu N
- Journal Title
  
  International Journal of Hematology
  
  Volume: 115 Issue: 2 Pages: 208-221
- DOI
  10.1007/s12185-021-03253-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-19K17871, KAKENHI-PROJECT-20H03713, KAKENHI-PROJECT-21H02949, KAKENHI-PROJECT-21K08407
[Journal Article] Circulating CD34+?cells of primary myelofibrosis patients contribute to myeloid-dominant hematopoiesis and bone marrow fibrosis in immunodeficient mice2021
- Author(s)
  Saito Noriyuki、Yamauchi Takuji、Kawano Noriaki、Ono Rintaro、Yoshida Shuro、Miyamoto Toshihiro、Kamimura Tomohiko、Shultz Leonard D.、Saito Yoriko、Takenaka Katsuto、Shimoda Kazuya、Harada Mine、Akashi Koichi、Ishikawa Fumihiko
- Journal Title
  
  International Journal of Hematology
  
  Volume: 115 Issue: 2 Pages: 198-207
- DOI
  10.1007/s12185-021-03239-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04827, KAKENHI-PROJECT-20H03713, KAKENHI-PROJECT-21H02949, KAKENHI-PROJECT-22K19544, KAKENHI-PROJECT-21H02951
[Journal Article] TKIs induce alternative spliced BCR-ABLIns35bp variant via inhibition of RNA polymerase Ⅱ on genomic BCR-ABL.2020
- Author(s)
  Yuda J, Odawara J, Minami M, Muta T, Kohno K, Tanimoto K, Eto T, Shima T, Kikushige Y, Kato K, Takenaka K, Iwasaki H, Minami Y, Ohkawa Y, Akashi K, Miyamoto T.
- Journal Title
  
  Cancer Sci
  
  Volume: 111 Issue: 7 Pages: 2361-2373
- DOI
  10.1111/cas.14424
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02840, KAKENHI-PROJECT-20K21398, KAKENHI-PUBLICLY-19H05244, KAKENHI-PUBLICLY-20H04846, KAKENHI-PROJECT-16H06391, KAKENHI-PROJECT-20H00456, KAKENHI-PROJECT-19H03687, KAKENHI-PROJECT-19H03424
[Journal Article] Outcome of allogeneic hematopoietic stem cell transplantation in adult patients with paroxysmal nocturnal hemoglobinuria2020
- Author(s)
  Nakamura Yukinori、Takenaka Katsuto、Yamazaki Hirohito、Onishi Yasushi、Ozawa Yukiyasu、Ikegame Kazuhiro、Matsuoka Ken-ichi、Toubai Tomomi、Ueda Yasunori、Kanda Yoshinobu、Ichinohe Tatsuo、Atsuta Yoshiko、Mori Takehiko
- Journal Title
  
  International Journal of Hematology
  
  Volume: 113 Issue: 1 Pages: 122-127
- DOI
  10.1007/s12185-020-02982-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02840
[Journal Article] Establishment of a human SIRPA knock-in xenograft mouse model to study human hematopoietic and cancer stem cells2020
- Author(s)
  Jinnouchi Fumiaki、Yamauchi Takuji、Yurino Ayano、Nunomura Takuya、Nakano Michitaka、Iwamoto Chika、Obara Teppei、Miyawaki Kohta、Kikushige Yoshikane、Kato Koji、Maeda Takahiro、Miyamoto Toshihiro、Baba Eishi、Akashi Koichi、Takenaka Katsuto
- Journal Title
  
  Blood
  
  Volume: - Issue: 19 Pages: 1661-1672
- DOI
  10.1182/blood.2019002194
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16366, KAKENHI-PROJECT-16H06391, KAKENHI-PROJECT-16H05340, KAKENHI-PROJECT-18H02840, KAKENHI-PROJECT-19H03687, KAKENHI-PROJECT-18K19565, KAKENHI-PROJECT-19K08818, KAKENHI-PROJECT-18K08362, KAKENHI-PROJECT-20H05699
[Journal Article] Safe childbirth for a type 1 antithrombin-deficient woman with novel mutation in the SERPINC1 gene undergoing antithrombin concentrate therapy.2019
- Author(s)
  Ikeda Y, Yamanouchi J, Hato T, Yasukawa M, Takenaka K
- Journal Title
  
  Blood Coagul Fibrinolysis
  
  Volume: 30 Issue: 1 Pages: 47-51
- DOI
  10.1097/mbc.0000000000000785
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08360, KAKENHI-PROJECT-18H02840, KAKENHI-PROJECT-18H02839
[Journal Article] Direct comparisoin of target-reactivity and cross-reactivity induced by CAR-and BiTE-redirected T cells for the development of antibody-based T-cell therapy.2019
- Author(s)
  Masaki Maruta, Toshiki Ochi, Kazushi Tanimoto, Hiroaki Asai, et al.
- Journal Title
  
  Scientific reports
  
  Volume: 9 Issue: 1 Pages: 13293-13293
- DOI
  10.1038/s41598-019-49834-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08330, KAKENHI-PROJECT-18K08331, KAKENHI-PROJECT-18K08361, KAKENHI-PROJECT-18H02839, KAKENHI-PROJECT-18H02840, KAKENHI-PROJECT-17K09957
[Journal Article] Escape hematopoiesis by HLA-B5401-lacking hematopoietic stem progenitor cells in men with acquired aplastic anemia.2019
- Author(s)
  Mahmoud I. Elbadry、Mizumaki Hiroki、Hosokawa Kohei、J. Luis Espinoza、Nakagawa Noriharu、Chonabayashi Kazuhisa、Yoshida Yoshinori、Katagiri Takamasa、Hosomichi Kazuyoshi、Zaimoku Yoshitaka、Imi Tatsuya、Mai Anh Thi Nguyen、Fujii Youichi、Tajima Atsushi、Ogawa Seishi、Takenaka Katsuto、Akashi Koichi、Nakao Shinji
- Journal Title
  
  Haematologica
  
  Volume: 印刷中 Issue: 10 Pages: 210856-210856
- DOI
  10.3324/haematol.2018.210856
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06502, KAKENHI-PROJECT-26221308, KAKENHI-PROJECT-16H05335, KAKENHI-PROJECT-18H02840, KAKENHI-PROJECT-16K09847, KAKENHI-PROJECT-17K19804, KAKENHI-PROJECT-17K16184, KAKENHI-PLANNED-15H05909, KAKENHI-PUBLICLY-19H05344, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-17K09007
[Journal Article] Comparison of outcomes of allogeneic transplantation for primary myelofibrosis among hematopoietic stem cell source groups.2019
- Author(s)
  Murata M, Takenaka K, Uchida N, Ozawa Y, Ohashi K, Kim SW, Ikegame K, Kanda Y, Kobayashi H, Ishikawa J, Ago H, Hirokawa M, Fukuda T, Atsuta Y, Kondo T.
- Journal Title
  
  Biology of Blood and Marrow Transplantation
  
  Volume: 25 Issue: 8 Pages: 1536-1543
- DOI
  10.1016/j.bbmt.2019.02.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08321, KAKENHI-PROJECT-18H02840, KAKENHI-PROJECT-19K08856
[Journal Article] Histone H3K27 Demethylase Negatively Controls the Memory Formation of Antigen-Stimulated CD8+ T Cells2019
- Author(s)
  Yamada Takeshi、Nabe Shogo、Toriyama Koji、Suzuki Junpei、Inoue Kazuki、Imai Yuuki、Shiraishi Atsushi、Takenaka Katsuto、Yasukawa Masaki、Yamashita Masakatsu
- Journal Title
  
  The Journal of Immunology
  
  Volume: 202 Issue: 4 Pages: 1088-1098
- DOI
  10.4049/jimmunol.1801083
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08887, KAKENHI-PUBLICLY-17H05794, KAKENHI-PROJECT-17H04086, KAKENHI-PROJECT-18H02840, KAKENHI-PROJECT-17K15728, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-18H02839, KAKENHI-PROJECT-17K11484
[Journal Article] Reinforce the antitumor activity of CD8+ T cells via glutamine restriction2018
- Author(s)
  Nabe Shogo、Yamada Takeshi、Suzuki Junpei、Toriyama Koji、Yasuoka Toshiaki、Kuwahara Makoto、Shiraishi Atsushi、Takenaka Katsuto、Yasukawa Masaki、Yamashita Masakatsu
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 12 Pages: 3737-3750
- DOI
  10.1111/cas.13827
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08887, KAKENHI-PROJECT-18K08409, KAKENHI-PUBLICLY-17H05794, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-17H04086, KAKENHI-PROJECT-18H02840, KAKENHI-PROJECT-17K15728, KAKENHI-PROJECT-17K16853, KAKENHI-PROJECT-18H02839
[Journal Article] E-cadherin regulates proliferation of colorectal cancer stem cells through NANOG.2018
- Author(s)
  Tamura S, Isobe T, Ariyama H, Nakano M, Kikushige Y, Takaishi S, Kusaba H, Takenaka K, Ueki T, Nakamura M, Akashi K, Baba E.
- Journal Title
  
  Oncology Reports
  
  Volume: 40 (2) Pages: 693-703
- DOI
  10.3892/or.2018.6464
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09460, KAKENHI-PROJECT-18H02840, KAKENHI-PROJECT-16H06250
[Journal Article] Hematopoiesis by iPSC-derived hematopoietic stem cells of aplastic anemia that escape cytotoxic T-cell attack2018
- Author(s)
  Espinoza J. Luis、Elbadry Mahmoud I.、Chonabayashi Kazuhisa、Yoshida Yoshinori、Katagiri Takamasa、Harada Kenichi、Nakagawa Noriharu、Zaimoku Yoshitaka、Imi Tatsuya、Hassanein Hassan A.、Khalifa A. Noreldin Amal、Takenaka Katsuto、Akashi Koichi、Hamana Hiroshi、Kishi Hiroyuki、Akatsuka Yoshiki、Nakao Shinji
- Journal Title
  
  Blood Adv
  
  Volume: 2 Issue: 4 Pages: 390-400
- DOI
  10.1182/bloodadvances.2017013342
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09007, KAKENHI-PLANNED-16H06499, KAKENHI-PROJECT-16H06391, KAKENHI-PROJECT-16H05335, KAKENHI-PROJECT-15K09512, KAKENHI-PROJECT-18H02840, KAKENHI-PROJECT-16K09847
[Journal Article] Dedifferentiation process driven by TGF-beta signaling enhances stem cell properties in human colorectal cancer2018
- Author(s)
  Nakano Michitaka、Kikushige Yoshikane、Miyawaki Kohta、Kunisaki Yuya、Mizuno Shinichi、Takenaka Katsuto、Tamura Shingo、Okumura Yuta、Ito Mamoru、Ariyama Hiroshi、Kusaba Hitoshi、Nakamura Masafumi、Maeda Takahiro、Baba Eishi、Akashi Koichi
- Journal Title
  
  Oncogene
  
  Volume: 38 Issue: 6 Pages: 780-793
- DOI
  10.1038/s41388-018-0480-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06391, KAKENHI-PROJECT-18H02841, KAKENHI-PROJECT-16H06250, KAKENHI-PROJECT-18H02840
[Journal Article] Recent advances in the diagnosis and management of primary myelofibrosis2018
- Author(s)
  Takenaka Katsuto、Shimoda Kazuya、Akashi Koichi
- Journal Title
  
  The Korean Journal of Internal Medicine
  
  Volume: 33 Issue: 4 Pages: 679-690
- DOI
  10.3904/kjim.2018.033
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04210, KAKENHI-PROJECT-18H02840
[Journal Article] Clinical features and outcomes of patients with primary myelofibrosis in Japan: report of a 17-year nationwide survey by the Idiopathic Disorders of Hematopoietic Organs Research Committee of Japan.2017
- Author(s)
  Takenaka K, Shimoda K, Uchida N, Shimomura T, Nagafuji K, Kondo T, Shibayama H, Mori T, Usuki K, Azuma T, Tsutsumi Y, Tanaka J, Dairaku H, Matsuo K, Ozawa K, Kurokawa M, Arai S, Akashi K.
- Journal Title
  
  Int J Henatol
  
  Volume: 105 Issue: 1 Pages: 59-69
- DOI
  10.1007/s12185-016-2102-3
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461424, KAKENHI-PROJECT-15K15365
[Journal Article] Enhanced Reconstitution of Human Erythropoiesis and Thrombopoiesis in an Immunodeficient Mouse Model with Kit(Wv) Mutations.2016
- Author(s)
  A. Yurino, K. Takenaka, T. Yamauchi, T. Nunomura, Y. Uehara, F. Jinnouchi, K. Miyawaki, Y. Kikushige, K. Kato, T. Miyamoto, H. Iwasaki, Y. Kunisaki, *K. Akashi
- Journal Title
  
  Stem Cell Reports
  
  Volume: 7 Issue: 3 Pages: 425-438
- DOI
  10.1016/j.stemcr.2016.07.002
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-26115009, KAKENHI-PROJECT-16H06391, KAKENHI-PROJECT-15H04859, KAKENHI-PROJECT-16H05340, KAKENHI-PROJECT-16H06250, KAKENHI-PROJECT-26461424, KAKENHI-PROJECT-15K15364, KAKENHI-PROJECT-16K09875, KAKENHI-PROJECT-15K15365
[Journal Article] Calreticulin mutation does not contribute to disease progression in essential thrombocythemia by inhibiting phagocytosis.2016
- Author(s)
  S. Daitoku, K. Takenaka, T. Yamauchi, A. Yurino, F. Jinnouchi, T. Nunomura, T. Eto, T. Kamimura, M. Higuchi, N. Harada, N. Saito, T. Miyamoto, H. Iwasaki, *K. Akashi
- Journal Title
  
  Exp Hematol
  
  Volume: 44 Issue: 9 Pages: 817-825
- DOI
  10.1016/j.exphem.2016.05.001
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26115009, KAKENHI-PROJECT-16H06391, KAKENHI-PROJECT-16H05340, KAKENHI-PROJECT-26461424, KAKENHI-PROJECT-15K15365
[Journal Article] Mogamulizumab Treatment Prior to Allogeneic Hematopoietic Stem Cell Transplantation Induces Severe Acute Graft-versus-Host Disease.2016
- Author(s)
  Sugio T, Kato K, Aoki T, Ohta T, Saito N, Yoshida S, Kawano I, Henzan H, Kadowaki M, Takase K, Muta T, Miyawaki K, Yamauchi T, Shima T, Takashima S, Mori Y, Yoshimoto G, Kamezaki K, Takenaka K, Iwasaki H, Ogawa R, Ohno Y, Eto T, Kamimura T, Miyamoto T, Akashi K.
- Journal Title
  
  Biol Blood Marrow Transplant.
  
  Volume: 22 Issue: 9 Pages: 1608-1614
- DOI
  10.1016/j.bbmt.2016.05.017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06391, KAKENHI-PROJECT-16H05340, KAKENHI-PROJECT-15K09455, KAKENHI-PROJECT-16K09875
[Journal Article] Splenic irradiation provides transient palliation for symptomatic splenomegaly associated with primary myelofibrosis: a report on 14 patients.2015
- Author(s)
  Kitanaka A, Takenaka K, Shide K, Miyamoto T, Kondo T, Ozawa K, Kurokawa M, Akashi K, Shimoda K.
- Journal Title
  
  Int J Hematol
  
  Volume: 103 Issue: 4 Pages: 423-428
- DOI
  10.1007/s12185-016-1940-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461424, KAKENHI-PROJECT-15K15365, KAKENHI-PROJECT-26461408, KAKENHI-PROJECT-15K09480
[Journal Article] Efficacy and safety of ruxolitinib in Asian patients with myelofibrosis.2015
- Author(s)
  Jung CW, Shih LY, Xiao Z, Jie J, Hou HA, Du X, Wang MC, Park S, Eom KS, Oritani K, Okamoto S, Tauchi T, Kim JS, Zhou D, Saito S, Li J, Handa H, Jianyong L, Ohishi K, Hou M, Depei W, Takenaka K, Liu T, Hu Y, Amagasaki T, Ito K, Gopalakrishna P, Akashi K.
- Journal Title
  
  Leuk Lymphoma
  
  Volume: 56 Issue: 7 Pages: 2067-2074
- DOI
  10.3109/10428194.2014.969260
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461424
[Journal Article] A TIM-3/Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid Leukemia Stem Cells and Leukemic Progression.2015
- Author(s)
  Kikushige Y, Miyamoto T, Yuda J, Jabbarzadeh-Tabrizi S, Shima T, Takayanagi S, Niiro H, Yurino A, Miyawaki K, Takenaka K, Iwasaki H, Akashi K
- Journal Title
  
  Cell Stem Cell.
  
  Volume: 17 Issue: 3 Pages: 341-352
- DOI
  10.1016/j.stem.2015.07.011
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09528, KAKENHI-PROJECT-26461424, KAKENHI-PROJECT-15K15365, KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-26115009, KAKENHI-PROJECT-25253069, KAKENHI-PROJECT-25461424, KAKENHI-PROJECT-26713034
[Journal Article] CD41 marks the initial myelo-erythroid lineage specification in adult mouse hematopoiesis: redefinition of murine common myeloid progenitor.2015
- Author(s)
  Miyawaki K, Arinobu Y, Iwasaki H, Kohno K, Tsuzuki H, Iino T, Shima T, Kikushige Y, Takenaka K, Miyamoto T, Akashi K.
- Journal Title
  
  Stem Cells
  
  Volume: 33 Issue: 3 Pages: 976-87
- DOI
  10.1002/stem.1906
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22130002, KAKENHI-PROJECT-23390254, KAKENHI-PROJECT-24659462, KAKENHI-PROJECT-24659463, KAKENHI-PROJECT-25253069, KAKENHI-PROJECT-25461424, KAKENHI-PLANNED-26115009, KAKENHI-PROJECT-26461424
[Journal Article] A multinational, open-label, phase 2 study of ruxolitinib in Asian patients with myelofibrosis: Japanese subset analysis.2015
- Author(s)
  Oritani K, Okamoto S, Tauchi T, Saito S, Ohishi K, Handa H, Takenaka K, Gopalakrishna P, Amagasaki T, Ito K, Akashi K.
- Journal Title
  
  Int J Hematol
  
  Volume: 101 Issue: 3 Pages: 295-304
- DOI
  10.1007/s12185-015-1746-8
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461424, KAKENHI-PROJECT-15K15365
[Journal Article] The BALB/c-specific polymorphic SIRPA enhances its affinity for human CD47, inhibiting phagocytosis against human cells to promote xenogeneic engraftment.2014
- Author(s)
  Iwamoto C
- Journal Title
  
  Exp Hematol
  
  Volume: 42 Issue: 3 Pages: 163-171
- DOI
  10.1016/j.exphem.2013.11.005
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-22130002, KAKENHI-PROJECT-23370061, KAKENHI-PROJECT-23390254, KAKENHI-PROJECT-23659202, KAKENHI-PROJECT-24659463, KAKENHI-PUBLICLY-25112709, KAKENHI-PROJECT-25253069, KAKENHI-PROJECT-25461424, KAKENHI-PLANNED-26115009
[Journal Article] The BALB/c-specific polymorphic SIRPA enhances its affinity for human CD47, inhibiting phagocytosis against human cells to promote xenogeneic engraftment.2014
- Author(s)
  Iwamoto C, Takenaka K, Urata S, Yamauchi T, Shima T, Kuriyama T, Daitoku S, Saito Y, Miyamoto T, Iwasaki H, Kitabayashi I, Itoh K, Kishimoto J, Kohda D, Matozaki T, Akashi K.
- Journal Title
  
  Exp Hematol
  
  Volume: 42 Pages: 163-171
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591392
[Journal Article] The ordered acquisition of Class II and Class I mutations directs formation of human t(8;21) acute myelogenous leukemia stem cell.2014
- Author(s)
  Shima T, Miyamoto T, Kikushige Y, Yuda J, Tochigi T, Yoshimoto G, Kato K, Takenaka K, Iwasaki H, Mizuno S, Goto N, Akashi K.
- Journal Title
  
  Exp. Hematol.
  
  Volume: 42 Issue: 11 Pages: 955-65
- DOI
  10.1016/j.exphem.2014.07.267
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-22130002, KAKENHI-PLANNED-22130009, KAKENHI-PROJECT-23390254, KAKENHI-PROJECT-24659462, KAKENHI-PROJECT-24659463, KAKENHI-PROJECT-25253069, KAKENHI-PROJECT-25461424, KAKENHI-PROJECT-25461453, KAKENHI-PLANNED-26115009, KAKENHI-PROJECT-26461424, KAKENHI-PROJECT-26640072
[Journal Article] The BALB/c-specific polymorphic SIRPA enhances its affinity for human CD47, inhibiting phagocytosis against human cells to promote xenogeneic engraftment2014
- Author(s)
  Iwamoto C, Takenaka K,以下14名
- Journal Title
  
  Exp Hematol
  
  Volume: 42(3) Pages: 163-71
- Data Source
  KAKENHI-PROJECT-23591392
[Journal Article] Quantitation of hematogones at the time of engraftment is a useful prognostic indicator in allogeneic hematopoietic stem cell transplantation.2013
- Author(s)
  Shima T, Miyamoto T, Kikushige Y, Mori Y, Kamezaki K, Takase K, Henzan H, Numata A, Ito Y, Takenaka K, Iwasaki H, Kamimura T, Eto T, Nagafuji K, Teshima T, Kato K, Akashi K
- Journal Title
  
  Blood
  
  Volume: 121 Pages: 840-848
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591392
[Journal Article] Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment2013
- Author(s)
  Yamauchi T, Takenaka ,以下12名
- Journal Title
  
  Blood
  
  Volume: 121(8) Pages: 1316-25
- NAID
  40019873170
- Data Source
  KAKENHI-PROJECT-23591392
[Journal Article] Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment.2013
- Author(s)
  Yamauchi T, Takenaka K, Urata S, Shima T, Kikushige Y, Tokuyama T, Iwamoto C, Nishihara M, Iwasaki H, Miyamoto T, Honma N, Nakao M, Matozaki T, Akashi K.
- Journal Title
  
  Blood
  
  Volume: 121 Pages: 1316-25
- NAID
  40019873170
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591392
[Journal Article] Quantitation of hematogones at the time of engraftment is a useful prognostic indicator in allogeneic hematopoietic stem cell transplantation.2013
- Author(s)
  Shima T, Miyamoto T, Kikushige Y, Mori Y, Kamezaki K, Takase K, Henzan H, Numata A, Ito Y, Takenaka K, Iwasaki H, Kamimura T, Eto T, Nagafuji K, Teshima T, Kato K, Akashi K.
- Journal Title
  
  Blood
  
  Volume: 121 Pages: 840-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591392
[Journal Article] Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment.2013
- Author(s)
  Yamauchi T, Takenaka K, Urata S, Shima T, Kikushige Y, Tokuyama T, Iwamoto C, Nishihara M, Iwasaki H, Miyamoto T, Honma N, Nakao M, Matozaki T, Akashi K
- Journal Title
  
  Blood
  
  Volume: 121 Pages: 1316-1325
- NAID
  40019873170
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591392
[Journal Article] Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment.2013
- Author(s)
  Yamauchi T
- Journal Title
  
  Blood
  
  Volume: 121 Issue: 8 Pages: 1316-1325
- DOI
  10.1182/blood-2012-06-440354
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-22130002, KAKENHI-PROJECT-22249039, KAKENHI-PROJECT-23370061, KAKENHI-PROJECT-23390254, KAKENHI-PROJECT-23659155, KAKENHI-PROJECT-24659462, KAKENHI-PROJECT-24659463, KAKENHI-PROJECT-25253069, KAKENHI-PUBLICLY-23112509
[Journal Article] Quantification of hematogones at the time of engraftment is a useful prognostic indicator in allogeneic stem cell transplantation.2013
- Author(s)
  Shima T
- Journal Title
  
  Blood
  
  Volume: 121 Issue: 5 Pages: 840-848
- DOI
  10.1182/blood-2012-02-409607
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390295, KAKENHI-PROJECT-22249039, KAKENHI-PROJECT-23390254, KAKENHI-PROJECT-23659490, KAKENHI-PROJECT-24659462, KAKENHI-PROJECT-24659463, KAKENHI-PROJECT-25293217, KAKENHI-PROJECT-25461453, KAKENHI-PROJECT-25670443, KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-22130002
[Journal Article] Contribution of bone marrow-derived hematopoietic stem/progenitor cells to the generation of donor-marker⁺ cardiomyocytes in vivo.2013
- Author(s)
  Fukata M, Ishikawa F, Najima Y, Yamauchi T, Saito Y, Takenaka K, Miyawaki K, Shimazu H, Shimoda K, Kanemaru T, Nakamura K, Odashiro K, Nagafuji K, Harada M, Akashi K.
- Journal Title
  
  PLoS One
  
  Volume: 8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591392
[Journal Article] Engulfment of hematopoietic stem cells caused by down-regulation of CD47 is critical in the pathogenesis of hemophagocytic lymphohistiocytosis2012
- Author(s)
  Kuriyama T, Takenaka K,以下12名
- Journal Title
  
  Blood
  
  Volume: 120(19) Pages: 4058-67
- Data Source
  KAKENHI-PROJECT-23591392
[Journal Article] Engulfment of hematopoietic stem cells caused by down-regulation of CD47 is critical in the pathogenesis of hemophagocytic lymphohistiocytosis.2012
- Author(s)
  Kuriyama T, Takenaka K, Kohno K, Yamauchi T, Daitoku S, Yoshimoto G, Kikushige Y, Kishimoto J, Abe Y, Harada N, Miyamoto T, Iwasaki H, Teshima T, Akashi K
- Journal Title
  
  Blood
  
  Volume: 120 Pages: 4058-4067
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591392
[Journal Article] Initial low-dose valganciclovir as a preemptive therapy is effective for cytomegalovirus infection in allogeneic hematopoietic stem cell transplant recipients2012
- Author(s)
  Takenaka K,以下13名
- Journal Title
  
  Int J Hematol
  
  Volume: 96(1) Pages: 94-100
- NAID
  10030954633
- Data Source
  KAKENHI-PROJECT-23591392
[Journal Article] Initial low-dose valganciclovir as a preemptive therapy is effective for cytomegalovirus infection in allogeneic hematopoietic stem cell transplant recipients.2012
- Author(s)
  Takenaka K, Nagafuji K, Takase K, Kamimura T, Mori Y, Ito Y, Nishi Y, Henzan H, Kato K, Harada N, Eto T, Miyamoto T, Teshima T, Akashi K.
- Journal Title
  
  Int J Hematol
  
  Volume: 96 Pages: 94-100
- NAID
  10030954633
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591392
[Journal Article] 白血病幹細胞2012
- Author(s)
  竹中克斗、赤司浩一
- Journal Title
  
  日本臨床
  
  Volume: 70 suppl 2 Pages: 139-145
- Data Source
  KAKENHI-PROJECT-23591392
[Journal Article] Engulfment of hematopoietic stem cel ls caused by down-regulation of CD47 is critical in the pathogenesis of hemophagocytic lymphohistiocytosis2012
- Author(s)
  Kuriyama T, Takenaka K 他12名
- Journal Title
  
  Blood
  
  Volume: 120巻 Issue: 19 Pages: 4058-4067
- DOI
  10.1182/blood-2012-02-408864
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390295, KAKENHI-PROJECT-22249039, KAKENHI-PROJECT-23390254, KAKENHI-PROJECT-23659490, KAKENHI-PROJECT-24659463, KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-22130002
[Journal Article] 骨髄不全症候群2012
- Author(s)
  竹中克斗
- Journal Title
  
  日本内科学会雑誌
  
  Volume: 101 Pages: 1969-1946
- Data Source
  KAKENHI-PROJECT-23591392
[Journal Article] Stem cell gene expression programs influence clinical outcome in human leukemia2011
- Author(s)
  Eppert K, Takenaka K, Lechman ER, et
- Journal Title
  
  Nat Med
  
  Volume: 17 Pages: 1086-1093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591392
[Journal Article] Selfrenewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia2011
- Author(s)
  Kikushige Y, Ishikawa F, Miyamoto T, Shima T, Urata S, Yoshimoto G, Mort Y, lino T, Yamauchi T, Eta T, Niiro H, Iwasaki H, Takenaka K, and Akashi K
- Journal Title
  
  Cancer Cell
  
  Volume: 20(2) Issue: 2 Pages: 246-259
- DOI
  10.1016/j.ccr.2011.06.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591267, KAKENHI-PROJECT-22249039
[Journal Article] JAK2 V617F uses distinct signalling pathways to induce cell proliferation and neutrophil activation.2011
- Author(s)
  Oku S, Takenaka K, Kuriyama T, Shide K, Kumano T, Kikushige Y, Urata S, Yamauchi T, Iwamoto C, Shimoda HK, Miyamoto T, Nagafuji K, Kishimoto J, Shimoda K, Akashi K.
- Journal Title
  
  Br J Haematol
  
  Volume: 150(3) Issue: 3 Pages: 334-344
- DOI
  10.1111/j.1365-2141.2010.08249.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249039
[Journal Article] Stem cell gene expression programs influence clinical outcome in human leukemia2011
- Author(s)
  Eppert K, Takenaka K,以下17名
- Journal Title
  
  Nat Med
  
  Volume: 17(9) Pages: 1086-93
- Data Source
  KAKENHI-PROJECT-23591392
[Journal Article] Self-renewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia2011
- Author(s)
  Kikushige Y, Ishikawa F, Miyamoto T, Shima T, Urata S, Yoshimoto G, Mori Y, Iino T, Yamauchi T, Eto T, Niiro H, Iwasaki H, Takenaka K, Akashi K
- Journal Title
  
  Cancer Cell
  
  Volume: 20 Pages: 246-259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591392
[Journal Article] JAK2 V617F uses distinct signalling pathways to induce cell proliferation and neutrophil activation2010
- Author(s)
  Oku S, Takenaka K, Kuriyama T, Shide K, Kumano T, Kikushige Y, Urata S, Yamauchi T, Iwamoto C, Shimoda HK, Miyamoto T, Nagafuji K, Kishimoto J, Shimoda K, Akashi K
- Journal Title
  
  Br J Haematol
  
  Volume: 150(3) Pages: 334-344
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249039
[Journal Article] TIM-3 is a promising target to selectively kill acute myeloid leukemia stem cells2010
- Author(s)
  Kikushige Y, Shima T, Takayanagi SI, Urata S, Miyamoto T, Iwasaki H, Takenaka K, Teshima T, Tanaka T, Inagaki Y, Akashi K
- Journal Title
  
  Cell Stem Cell
  
  Volume: 7(6) Pages: 708-717
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249039
[Journal Article] TIM-3 is a promising target to selec tively kill acute myeloid leukemia s tem cells2010
- Author(s)
  Kikushige Y, Shima T 他7名
- Journal Title
  
  Cell Stem Cell
  
  Volume: 7巻 Issue: 6 Pages: 708-717
- DOI
  10.1016/j.stem.2010.11.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390295, KAKENHI-PROJECT-22249039, KAKENHI-PROJECT-22590440
[Journal Article] JAK2 V617F uses distinct signalling pathways to induce cell proliferation and neutrophil activation.2010
- Author(s)
  Oku S, Takenaka K
- Journal Title
  
  Br J Haematol 150
  
  Pages: 334-344
- Data Source
  KAKENHI-PROJECT-20591134
[Journal Article] Stem cell gene expression programs influence clinical outcome in human leukemia.
- Author(s)
  Eppert K, Takenaka K
- Journal Title
  
  Nat Med (in press).
- Data Source
  KAKENHI-PROJECT-20591134
[Presentation] 再生不良性貧血に対する同種造血幹細胞移植後サイトメガロウイルス再活性化の移植後予後に及ぼす影響2021
- Author(s)
  竹中克斗
- Organizer
  第43回日本造血細胞移植学会
- Data Source
  KAKENHI-PROJECT-18H02840
[Presentation] 血液疾患治療の最新の話題2020
- Author(s)
  竹中克斗
- Organizer
  第63回日本内科学会四国支部生涯教育講演会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02840
[Presentation] PMF診療の最前線2020
- Author(s)
  竹中克斗
- Organizer
  第82回日本血液学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02840
[Presentation] 移植後サイトメガロウイルス感染症に対する新たな戦略2019
- Author(s)
  竹中克斗
- Organizer
  第67回日本輸血・細胞治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02840
[Presentation] Clinical debate 7 MPN2019
- Author(s)
  竹中克斗
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02840
[Presentation] 教育講演　MPNにおける同種造血幹細胞移植2019
- Author(s)
  竹中克斗
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02840
[Presentation] Introduction of Macrophage Tolerance By Human SIRPA Knock-in Enhances Peripheral Reconstitution of Human Hematopoiesis in Xenotransplantation Model2016
- Author(s)
  Jinnnouchi F, Takenaka K, Iwamoto C, Yamauchi T, Yurino A, Nunomura T, Kikushige Y, Kato K, Miyamoto T, Akashi K
- Organizer
  the 58th of annual meeting of American Society of Hematology
- Place of Presentation
  San Diego, CA
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461424
[Presentation] Fibrotic tissues in human primary myelofibrosis with JAK2V617F are developed clonally from malignant hematopoietic stem cells2015
- Author(s)
  Katsuto Takenaka
- Organizer
  The 6th JSH International Symposium 2015
- Place of Presentation
  Karuizawa, Japan
- Year and Date
  2015-05-23
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461424
[Presentation] BALB/c- specific L29V polymorphism in SIRPA determines the efficient engraftment of human hematopoiesis in xenogeneic model2013
- Author(s)
  Iwamoto C, Takenaka K, et al
- Organizer
  第55回米国血液学会
- Place of Presentation
  ニューオリンズ、米国
- Year and Date
  2013-12-09
- Data Source
  KAKENHI-PROJECT-23591392
[Presentation] Fibrotic tissues in human primary myelofibrosis with JAK2 V617F are developed clonally from malignant hematopoietic stem cells2013
- Author(s)
  amauchi T, Shima T, Takenaka K, et al
- Organizer
  第55回米国血液学会
- Place of Presentation
  ニューオリンズ、米国
- Year and Date
  2013-12-08
- Data Source
  KAKENHI-PROJECT-23591392
[Presentation] 教育講演48　移植後のウイルス感染症2013
- Author(s)
  竹中克斗
- Organizer
  第75回日本血液学会
- Place of Presentation
  札幌市
- Invited
- Data Source
  KAKENHI-PROJECT-23591392
[Presentation] 同種造血幹細胞移植後早期のCMV再活性化が急性白血病再発に及ぼす影響2013
- Author(s)
  竹中克斗
- Organizer
  第35回日本造血細胞移植学会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23591392
[Presentation] Cytomegalovirus Reactivation After Allogeneic Stem Cell Transplantation Is Associated With a Reduced Risk Of Relapse In Patients With Acute Myeloid Leukemia2013
- Author(s)
  Katsuto Takenaka
- Organizer
  the 55th American Society of Hematology Annual Meeting
- Place of Presentation
  New Orleans, LA, USA
- Data Source
  KAKENHI-PROJECT-23591392
[Presentation] Cytomegalovirus reactivation after allogeneic stem cell transplantation is associated with a reduced risk of relapse in patients with acute myeloid leukemia2013
- Author(s)
  Katsuto Takenaka
- Organizer
  第55回米国血液学会
- Place of Presentation
  ニューオリンズ、米国
- Year and Date
  2013-12-10
- Data Source
  KAKENHI-PROJECT-23591392
[Presentation] ヒト造血アッセイのための異種移植システムの進歩2012
- Author(s)
  竹中克斗
- Organizer
  第74回日本血液学会
- Place of Presentation
  京都
- Year and Date
  2012-10-20
- Invited
- Data Source
  KAKENHI-PROJECT-23591392
[Presentation] 急性骨髄性白血病幹細胞遺伝子発現プロファイルの臨床的意義2012
- Author(s)
  竹中克斗
- Organizer
  第22回日本サイトメトリー学会
- Place of Presentation
  大阪
- Year and Date
  2012-06-30
- Invited
- Data Source
  KAKENHI-PROJECT-23591392
[Presentation] Hemophagocytic lymphohistiocytosis is caused by engulfment of hematopoietic stem cells by macrophages through stem cell-specific suppression of CD47 under influence of cytokine deregulation2011
- Author(s)
  Kuriyama T, Takenaka K, et al
- Organizer
  第53回米国血液学会
- Place of Presentation
  サンディエゴ、米国
- Year and Date
  2011-12-12
- Data Source
  KAKENHI-PROJECT-23591392
[Presentation] The Efficient Engraftment of Human Hematopoiesis in the Balb/c Strain Is Mounted by Balb/c-Specific SIRPA Polymorphism That Enhances Binding Affinity to Human CD472011
- Author(s)
  Iwamoto C, Takenaka K, et al
- Organizer
  Annual Meeting of the American Society of Hematology 2011
- Place of Presentation
  San Diego、米国
- Data Source
  KAKENHI-PROJECT-23591392
[Presentation] Hemophagocytic Lymphohistiocytosis Is Caused by Engulfment of Hematopoietic Stem Cells by Macrophages Through Stem Cell-Specific Suppression of CD47 Under Influence of Cytokine Deregulation2011
- Author(s)
  Kuriyama T, Takenaka K, et al
- Organizer
  Annual Meeting of the American Society of Hematology 2011
- Place of Presentation
  San Diego、米国
- Data Source
  KAKENHI-PROJECT-23591392
[Presentation] The efficient engraftment of human hematopoiesis in the Balb/c strain is mounted by Balb/c-specific SIRPA polymorphism that enhances binding affinity to human CD472011
- Author(s)
  Iwamoto C, Takenaka K, et al
- Organizer
  第53回米国血液学会
- Place of Presentation
  サンディエゴ、米国
- Year and Date
  2011-12-12
- Data Source
  KAKENHI-PROJECT-23591392
[Presentation] Identification of a new genetic determinant controlling human hematopoietic stem cell engraftment.2007
- Author(s)
  Takenaka K, et. al.
- Organizer
  The American Society of Hematology 49^<th> Annual Meeting
- Place of Presentation
  Atlanta, USA
- Data Source
  KAKENHI-PROJECT-17390281
[Presentation] Identification of a new genetic determinant controlling human hematopoietic stem cell engraftment2007
- Author(s)
  K., Takenaka, et. al.
- Organizer
  The American Society of Hematology 49th Annual Meeting December
- Place of Presentation
  Atlanta, USA
- Year and Date
  2007-08-11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390281
[Presentation] Identification of a new genetic determinant controlling human hematopoietic stem cell engraftment2007
- Author(s)
  Takenaka K, et. al.
- Organizer
  The American Society of Hematology 49th Annual Meeting
- Place of Presentation
  Atlanta,USA
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390281
[Presentation] 日本造血細胞移植学会ガイドライン　サイトメガロウイルス感染症
- Author(s)
  竹中克斗
- Organizer
  第34回日本造血細胞移植学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23591392
[]

1. ISHIMARU Fumihiko (50284097)

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26. HOSOMICHI Kazuyoshi

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Takenaka Katsuto 竹中 克斗

TAKENAKA Katsuto 竹中 克斗

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免疫腫瘍学分野における次世代ヒト化患者腫瘍組織移植モデルプラットフォームの樹立Principal Investigator

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Development of next-generation patient-derived xenograft models for precision medicinePrincipal Investigator

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Cancer stem cell purification and drug discovery support by the overall disease model using a new PDX modelPrincipal Investigator

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Targeting cancer stem cells in chronic myeloid neoplasmsPrincipal Investigator

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Targeting cancer stem cells in myelodysplastic syndromePrincipal Investigator

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Functional analysis of miRNA/transcription factors highly expressed in leukemia stem cellsPrincipal Investigator

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Takenaka Katsuto 竹中克斗

TAKENAKA Katsuto 竹中克斗