Simizu Siro 清水史郎

… Alternative Names

清水史郎シミズシロウ

SIMIZU Siro 清水史郎

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Researcher Number	30312268
Other IDs
External Links
Affiliation (Current)	2025: 慶應義塾大学, 理工学部(矢上), 教授
Affiliation (based on the past Project Information) *help	2024: 慶應義塾大学, 理工学部(矢上), 教授 2018 – 2020: 慶應義塾大学, 理工学部(矢上), 教授 2012 – 2014: 慶應義塾大学, 理工学部, 准教授 2011: 慶應義塾大学, 理工学部, 専任講師 2010 – 2011: The Institute of Physical and Chemical Research, 理工学部, 講師 … More 2009: 独立行政法人理化学研究所, 化合物ライブラリー評価研究チーム, 専任研究員 2009: The Institute of Physical and Chemical Research, 化合物ライブラリー評価研究チーム, 専任研究貴 2008: The Institute of Physical and Chemical Research, 基幹研究所・長田抗生物質研究室, 専任研究員 2007 – 2008: 独立行政法人理化学研究所, 長田抗生物質研究室, 専任研究員 2007: The Institute of Physical and Chemical Research, 長田抗生物質研究室, 専任研究員 2004 – 2006: 独立行政法人理化学研究所, 長田抗生物質研究室, 研究員 2000 – 2003: 理化学研究所, 抗生物質研究室, 研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 43030:Functional biochemistry-related / Living organism molecular science / Biological Sciences / Functional biochemistry / Chemical biology / Biological Sciences Except Principal Investigator Science and Engineering / Chemical biology / Biological Sciences / Biological Sciences
Keywords	Principal Investigator ヘパラナーゼ / がん細胞 / C型糖修飾 / PP2A / phoslactomycin / ERKs / apoptosis / 低分子化合物 / Pirin / ケミカルバイオロジー … More / ジスルフィド結合 / 転移・浸潤 / ヘパラン硫酸 / ゼブラフィッシュ / がん分子標的 / フィブリノーゲンC末端領域 / 細胞外分泌 / Isthmin-1 / ADAMTS4 / MFAP4 / R-spondin2 / ERK2 / 細胞周期 / リン酸化 / ミトコンドリア / Bc1-2 / Erk / Bcl-2 / 構造活性相関 / 骨転移 / 骨粗鬆症 / 骨疾患 / RANKL / 破骨細胞分化 / 破骨細胞 / 骨関連疾患 / NPDepo / 赤色蛍光タンパク質 / 公的化合物バンク施設 / 分化誘導 / メラノーマ細胞 / がん細胞遊走 / 化合物バンク / VCP / G3BP / RelB / NF-κB / PDGF / がん細胞の浸潤・転移 / 細胞内ロジスティクス / 化合物アレイ / 質量分析 / システイン化 / がん転移 / プロテオーム法 / 化学生物学 / 生体高分子 / RECK / マトリックスメタロプロテアーゼ / 転移 / 糖鎖修飾 / プロテインキナーゼC / DNAメチル化 / mRNA / RT-PCR法 / WI-38細胞 / HepG2細胞 … More Except Principal Investigator isoavenaciolide / phoslactomycin / 蛋白質機能モジュレーター / リガンドスクリーニング / 低分子アフィニティービーズ / 低分子マイクロアレイ / アポトーシス / ケミカルバイオロジー / dephosphorylation / apoptosis / biosynthesis / inhibitor / phosphatase / テトロン酸 / 分子設計 / RK-682 / 活性中心 / Michael付加 / VHR / 4-isoavenaciolide / リン酸化 / Bcl-2 / 脱リン酸化 / 生合成系 / 阻害剤 / ホスファターゼ / 光プローブ / 標的タンパク質 / 探索プローブ / NF-κB / 卵巣癌 / メラノーマ / アノイキス / 転移 / 卵巣がん / pyrapaxilline / Exo-ene EQ / migracin / DTCM-glutarimide / DHMEQ / NF-kappa B / 遊走 / 浸潤 / 腹腔内転移 / バイオイメージング / 分子デザイン / 高次生体システム / 情報科学 / 疾患 / アウトリーチ / 融合研究 / 病態の理解 / 細胞内ロジスティクス / 画像解析 / オルガネラ / 社会還元 / 成果報告 / 情報発信 / 分子細胞生物学 / 情報科学・工学 / 細胞内輸送 / メンブレントラフィック / 金属依存性マトリックス分解酵素 / 破骨細胞 / がん細胞 / V-ATPase / イエジマライド / 骨転移 / リベロマイシンA / ビオチン / VEGF / 血管内皮細胞 / Epoxyquinol B / 放線菌 / GLO1 / メチルゲルフィリン / 2D-DIGE / リベロマイシン / p38 / 生合成遺伝子 / プロテオミクス / フミトレモルジン / プロテオーム / 天然化合物 / 血管新生 / 癌転移 Less

Role of C-mannosylation in zebrafish and development of inhibitors for C-mannosylationPrincipal Investigator
- Principal Investigator
  
  清水史郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Keio University
Identification of novel enzymes for C-mannosylation and analysis of its substrate proteinsPrincipal Investigator
- Principal Investigator
  
  Simizu Siro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Keio University
Development of novel drug for bone-related diseases using Pirin inhibitorsPrincipal Investigator
- Principal Investigator
  
  SIMIZU Siro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical biology
- Research Institution
  Keio University
Bio-imaging of peritoneal metastasis and molecular design of inhibitors
- Principal Investigator
  
  UMEZAWA Kazuo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical biology
- Research Institution
  Aichi Medical University
  Keio University
Administration of the group grant "Intracellular logistics: interdisciplinary approaches to pathophysiology of membrane traffic"
- Principal Investigator
  
  YOSHIMORI Tamotsu
- Project Period (FY)
  2008 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Analysis of intracellular logistics by chemical biologyPrincipal Investigator
- Principal Investigator
  
  SIMIZU Siro
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
  The Institute of Physical and Chemical Research
低分子マイクロアレイを用いた蛋白質機能モジュレーターの探索と創成
- Principal Investigator
  
  叶直樹
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Tohoku University
天然由来低分子マイクロアレイを発端とした蛋白質機能モジュレーターの探索と創成
- Principal Investigator
  
  叶直樹
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Tohoku University
Analyses of glycosylation-regulated tumor metastasis by chemical biology approachPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Siro
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Living organism molecular science
- Research Institution
  The Institute of Physical and Chemical Research
Drug discovery research based on the molecular mechanisms of tumor growth and metastasis
- Principal Investigator
  
  OSADA Hiroyuki
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
糖鎖修飾によるタンパク質活性化調節機構の解析Principal Investigator
- Principal Investigator
  
  清水史郎
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  The Institute of Physical and Chemical Research
ヘパラナーゼ阻害剤探索系の構築と活性化機構の解析Principal Investigator
- Principal Investigator
  
  清水史郎
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
Role of Bcl-2 phosphorylation after microtubule disruptionPrincipal Investigator
- Principal Investigator
  
  SIMIZU Siro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  RIKEN
ヘパラナーゼ阻害剤探索系の構築と活性化機構の解析Principal Investigator
- Principal Investigator
  
  清水史郎
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
Chemical biology study on protein phosphatases and their specific inhibitors.
- Principal Investigator
  
  OSADA Hiroyuki
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  RIKEN

[Book] がん分子標的治療研究ハンドブック2009
- Author(s)
  清水史郎、宮崎功、本田香織、近藤恭光、長田裕之
- Publisher
  金芳堂
- Data Source
  KAKENHI-PLANNED-20113008
[Book] 化合物アレイを用いた抗がん剤探索系「がん分子標的治療研究実践マニュアル(日本がん分子標的治療学会編)」2009
- Author(s)
  清水史郎, 他
- Total Pages
  340
- Publisher
  金芳堂
- Data Source
  KAKENHI-PROJECT-17016079
[Book] 化合物アレイを用いた抗がん剤探索系がん分子標的治療研究実践マニュアル2009
- Author(s)
  清水史郎、宮崎功、本田香織、近藤恭光、長田裕之、金芳堂
- Publisher
  日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-17016079
[Book] 浸潤と転移-1タンパク質分解酵素と糖分解酵素「がんの分子標的治療(鶴尾隆編)」2008
- Author(s)
  清水史郎、長田裕之
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-17016079
[Book] がんの分子標的治療第III部 25 「浸潤と転移-1 タンパク質分解酵素と糖分解酵素」2008
- Author(s)
  清水史郎, 他
- Total Pages
  441
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-17016079
[Book] がんの分子標的治療2008
- Author(s)
  清水史郎、長田裕之
- Publisher
  南山堂
- Data Source
  KAKENHI-PLANNED-20113008
[Book] 「低分子アレイ」マイクロアレイ・バイオチップの最新技術2007
- Author(s)
  清水史郎, 宮崎功, 近藤恭光, 叶直樹, 長田裕之
- Total Pages
  305
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-18681035
[Book] マイクロアレイ・バイオチップの最新技術2007
- Author(s)
  清水史郎
- Total Pages
  305
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-19021005
[Book] マイクロアレイ・バイオチップの最新技術2007
- Author(s)
  清水史郎、他
- Total Pages
  305
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-18681035
[Book] マイクロアレイ・バイオチップの最新技術2007
- Author(s)
  清水史郎
- Total Pages
  305
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-18038044
[Journal Article] Requirement for C-mannosylation to be secreted and activated a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4)2021
- Author(s)
  Miura K、Suzuki T、Sun H、Takada H、Ishizawa Y、Mizuta H、Dohmae N、Simizu S
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - General Subjects
  
  Volume: 1865 Issue: 3 Pages: 129833-129833
- DOI
  10.1016/j.bbagen.2020.129833
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06137
[Journal Article] Identification of madangamine A as a novel lysosomotropic agent to inhibit autophagy2021
- Author(s)
  Miura Kazuki、Kawano Sayaka、Suto Takahiro、Sato Takaaki、Chida Noritaka、Simizu Siro
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 34 Pages: 116041-116041
- DOI
  10.1016/j.bmc.2021.116041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22189, KAKENHI-PROJECT-18H01984, KAKENHI-PROJECT-18K06137
[Journal Article] Seven‐Step Synthesis of All‐Nitrogenated Sugar Derivatives Using Sequential Overman Rearrangements2021
- Author(s)
  Okuyama Yuya、Kidena Mayu、Kato Erina、Kawano Sayaka、Ishii Koki、Maie Kenta、Miura Kazuki、Simizu Siro、Sato Takaaki、Chida Noritaka
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 60 Issue: 10 Pages: 5193-5198
- DOI
  10.1002/anie.202015141
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22189, KAKENHI-PROJECT-18H01984, KAKENHI-PROJECT-19J12788, KAKENHI-PROJECT-18K05127, KAKENHI-PROJECT-18K06137
[Journal Article] Regulation of N-glycosylation and secretion of Isthmin-1 by its C-mannosylation2021
- Author(s)
  Yoshimoto S、Katayama K、Suzuki T、Dohmae N、Simizu S
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - General Subjects
  
  Volume: 1865 Issue: 3 Pages: 129840-129840
- DOI
  10.1016/j.bbagen.2020.129840
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06137
[Journal Article] Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer2021
- Author(s)
  Mizuta Hayato、Okada Koutaroh、Araki Mitsugu、Adachi Jun、Takemoto Ai、Kutkowska Justyna、Maruyama Kohei、Friboulet Luc、Katayama Kazuhiro、Ma Biao、Sasakura Yoko、Sagae Yukari、Kukimoto-Niino Mutsuko、Shirouzu Mikako、Takagi Satoshi、Simizu Siro、Nishio Makoto、Okuno Yasushi、Fujita Naoya、Katayama Ryohei, et al
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 1261-1261
- DOI
  10.1038/s41467-021-21396-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21554, KAKENHI-PLANNED-17H06327, KAKENHI-PROJECT-19H03524, KAKENHI-PROJECT-18K06137, KAKENHI-PROJECT-19K22572, KAKENHI-PROJECT-18K06594, KAKENHI-ORGANIZER-17H06324
[Journal Article] Identification of vibsanin A analog as a novel HSP90 inhibitor2020
- Author(s)
  Miura Kazuki、Matsuki Wataru、Ogura Akihiro、Takao Ken-ichi、Simizu Siro
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 28 Issue: 2 Pages: 115253-115253
- DOI
  10.1016/j.bmc.2019.115253
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06137, KAKENHI-PROJECT-19K15571
[Journal Article] The fibrinogen C-terminal domain is seldom C-mannosylated but its C-mannosylation is important for the secretion of microfibril-associated glycoprotein 42020
- Author(s)
  Osada Y、Suzuki T、Mizuta H、Mori K、Miura K、Dohmae N、Simizu S
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - General Subjects
  
  Volume: 1864 Issue: 9 Pages: 129637-129637
- DOI
  10.1016/j.bbagen.2020.129637
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06137
[Journal Article] Total Synthesis of Natural Products Using Intramolecular Nozaki?Hiyama?Takai?Kishi Reactions2020
- Author(s)
  Takao Ken-ichi、Ogura Akihiro、Yoshida Keisuke、Simizu Siro
- Journal Title
  
  Synlett
  
  Volume: 31 Issue: 05 Pages: 421-433
- DOI
  10.1055/s-0039-1691580
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06137, KAKENHI-PROJECT-19K15571
[Journal Article] Cell-dependent regulation of vasculogenic mimicry by carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1)2020
- Author(s)
  Hayashi Soichiro、Osada Yoshiyuki、Miura Kazuki、Simizu Siro
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 21 Pages: 100734-100734
- DOI
  10.1016/j.bbrep.2020.100734
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06137
[Journal Article] Identification of topoisomerases as molecular targets of cytosporolide C and its analog2019
- Author(s)
  Otake Keisuke、Yamada Kana、Miura Kazuki、Sasazawa Yukiko、Miyazaki So、Niwa Yuki、Ogura Akihiro、Takao Ken-ichi、Simizu Siro
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 27 Issue: 15 Pages: 3334-3338
- DOI
  10.1016/j.bmc.2019.06.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06137, KAKENHI-PROJECT-19K15571, KAKENHI-PROJECT-18K15464, KAKENHI-PROJECT-16H06276
[Journal Article] Identification and characterization of collagen-like glycosylation and hydroxylation of CCN12019
- Author(s)
  Ishizawa Yudai、Niwa Yuki、Suzuki Takehiro、Kawahara Ryota、Dohmae Naoshi、Simizu Siro
- Journal Title
  
  Glycobiology
  
  Volume: 29 Issue: 10 Pages: 696-704
- DOI
  10.1093/glycob/cwz052
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06137
[Journal Article] C-mannosylation of R-spondin2 activates Wnt/β-catenin signaling and migration activity in human tumor cells.2019
- Author(s)
  Mizuta, H., Kuga, K., Suzuki, T., Niwa, Y., Dohmae, N. & Simizu, S.
- Journal Title
  
  International Journal of Oncology
  
  Volume: - Pages: 2127-2138
- DOI
  10.3892/ijo.2019.4767
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06137, KAKENHI-PROJECT-17K15094
[Journal Article] Unified total synthesis of madangamine alkaloids.2019
- Author(s)
  Suto, T., Yanagita, Y., Nagashima, Y., Takikawa, S., Kurosu, Y., Matsuo, N., Miura, K., Simizu, S., Sato, T. & Chida, N.
- Journal Title
  
  Bulletin of the Chemical Society of Japan
  
  Volume: 92 Pages: 545-571
- NAID
  130007611672
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06137
[Journal Article] C-mannosylation; previous studies and future research perspectives.2018
- Author(s)
  Niwa, Y. & Simizu, S.
- Journal Title
  
  Trends in Glycoscience and Glycotechnology
  
  Volume: 30
- NAID
  130007521336
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06137
[Journal Article] Integrin β1 is an essential factor in vasculogenic mimicry of human cancer cells.2018
- Author(s)
  Kawahara, R., Niwa, Y. & Simizu, S.
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 8 Pages: 2490-2496
- DOI
  10.1111/cas.13693
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06137, KAKENHI-PROJECT-17K15094
[Journal Article] Activation of apoptosis by caspase-3-dependent specific RelB cleavage in anticancer agent-treated cancer cells: involvement of positive feedback mechanism2015
- Author(s)
  Kuboki M, Ito A, Simizu S, Umezawa K.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 456 Issue: 3 Pages: 810-814
- DOI
  10.1016/j.bbrc.2014.12.024
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24310167
[Journal Article] Inhibition of MMP-2-Mediated Mast Cell Invasion by NF-κB Inhibitor DHMEQ in Mast Cells2015
- Author(s)
  Noma N, Asagiri M, Takeiri M, Ohmae S, Takemoto K, Iwaisako K, Minato N, Maeda-Yamamoto M, Simizu S, Umezawa K.
- Journal Title
  
  Int. Arch. Allergy Immunol.
  
  Volume: 166 Pages: 84-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24310167
[Journal Article] N-Glycosylation of extracellular matrix protein 1 (ECM1) regulates its secretion, which is unrelated to lipoid proteinosis2015
- Author(s)
  Uematsu S, Goto Y, Suzuki T, Sasazawa Y, Dohmae N, Simizu S.
- Journal Title
  
  FEBS Open Bio
  
  Volume: 4 Issue: 1 Pages: 879-885
- DOI
  10.1016/j.fob.2014.10.004
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24310167, KAKENHI-PROJECT-26750373
[Journal Article] Isolation of a novel paxilline analog pyrapaxilline from fungus that inhibits LPS-induced NO production2015
- Author(s)
  Matsui C, Ikeda Y, Iinuma H, Kushida N, Kunisada T, Simizu S, Umezawa K.
- Journal Title
  
  J. Antibiot.
  
  Volume: 67 Issue: 11 Pages: 787-790
- DOI
  10.1038/ja.2014.63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24310167
[Journal Article] Pirin regulates the epithelial to mesenchymal transition independently of Bcl3-Slug signaling.2015
- Author(s)
  Komai, K., Niwa, Y., Sasazawa, Y. & Simizu, S.
- Journal Title
  
  FEBS Lett.
  
  Volume: 589 Issue: 6 Pages: 738-743
- DOI
  10.1016/j.febslet.2015.01.040
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-13J04256, KAKENHI-PROJECT-24310167, KAKENHI-PROJECT-26750373
[Journal Article] Conophylline Protects Cells in Cellular Models of Neurodegenerative Diseases by Inducing Mammalian Target of Rapamycin (mTOR)-independent Autophagy2015
- Author(s)
  Sasazawa Y, Sato N, Umezawa K, Simizu S.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 290 Issue: 10 Pages: 6168-6178
- DOI
  10.1074/jbc.m114.606293
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24310167, KAKENHI-PROJECT-26750373
[Journal Article] Isolation of a novel paxilline analog pyrapaxilline from fungus that inhibits LPS-induced NO production2014
- Author(s)
  C. Matsui, Y. Ikeda, H. Iinuma, N. Kushida, T. Kunisada, S. Simizu and K. Umezawa
- Journal Title
  
  J. Antibiotics
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] C-mannosylation of human hyaluronidase 1: Possible roles for secretion and enzymatic activity.2014
- Author(s)
  Goto, Y., Niwa, Y., Suzuki, T., Dohmae, N., Umezawa, K. & Simizu, S.
- Journal Title
  
  Int. J. Oncol.
  
  Volume: 45 Issue: 1 Pages: 344-350
- DOI
  10.3892/ijo.2014.2438
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-13J04256, KAKENHI-PROJECT-24310167
[Journal Article] Involvement of conserved tryptophan residues for secretion of TIMP-22014
- Author(s)
  Ukaji, T., Sasazawa, Y., Umezawa, K. & Simizu, S.
- Journal Title
  
  Oncology Letters
  
  Volume: 7 Pages: 631-634
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24310167
[Journal Article] N-glycosylation is required for secretion and enzymatic activity of human hyaluronidase1.2014
- Author(s)
  Goto, Y., Niwa, Y., Suzuki, T., Uematsu, S., Dohmae, N. & Simizu, S.
- Journal Title
  
  FEBS Open Bio
  
  Volume: 4 Issue: 1 Pages: 554-559
- DOI
  10.1016/j.fob.2014.06.001
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J04256, KAKENHI-PROJECT-24310167
[Journal Article] Inhibition of NO-induced β-cell death by novel NF-κB inhibitor (-)-DHMEQ via activation of Nrf2-ARE pathway2013
- Author(s)
  A. Ogasawara, S. Simizu, A. Ito, T. Kawai, Y. Saisho, I. Takei and K. Umezawa
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 433 Pages: 181-187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Migracins A and B, new inhibitors of cancer cell migration, produced by Streptomyces sp2013
- Author(s)
  Y. Arai, H. Iinuma, Y. Ikeda, M. Igarashi, K. Hatano, N. Kinoshita, T. Ukaji, S. Simizu and K. Umezawa
- Journal Title
  
  J. Antibiot.
  
  Volume: 66
- NAID
  10031168683
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Migracins A and B, new inhibitors of cancer cell migration, produced by Streptomyces sp2013
- Author(s)
  Arai, Y., Iinuma, H., Ikeda, Y., Igarashi, M., Hatano, M., Kinoshita, N., Ukaji, T., Simizu, S. & Umezawa, K
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: (掲載決定) Issue: 4 Pages: 225-230
- DOI
  10.1038/ja.2012.112
- NAID
  10031168683
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20113008, KAKENHI-PROJECT-24310167
[Journal Article] Migracins A and B, new inhibitors of cancer cell migration, produced by Streptomyces sp2013
- Author(s)
  Y. Arai, H. Iinuma, Y. Ikeda, M. Igarashi, K. Hatano, N. Kinoshita, T. Ukaji, S. Simizu and K. Umezawa
- Journal Title
  
  J. Antibiot
  
  Volume: 66 Pages: 225-230
- NAID
  10031168683
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Inhibition of NO-induced β-cell death by novel NF-κB inhibitor (-)-DHMEQ via activation of Nrf2-ARE pathway2013
- Author(s)
  Ogasawara, A., Simizu, S., Ito, A., Kawai, T., Saisho, Y., Takei, I. & Umezawa, K
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: (掲載決定) Issue: 2 Pages: 181-187
- DOI
  10.1016/j.bbrc.2013.02.062
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20113008, KAKENHI-PROJECT-24310167
[Journal Article] Determination of topological structure of ARL6ip1 in cells: identification of the essential binding region of ARL6ip1 for conophylline2013
- Author(s)
  Kuroda, M., Funasaki, S., Saitoh, T., Sasazawa, Y., Nishiyama, S., Umezawa, K. & Simizu, S.
- Journal Title
  
  FEBS Letters
  
  Volume: 587 Issue: 22 Pages: 3656-3660
- DOI
  10.1016/j.febslet.2013.09.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24310167, KAKENHI-PROJECT-24810025
[Journal Article] Practical molecular targets for suppression of metastasis2013
- Author(s)
  Simizu, S. & Niwa, Y.
- Journal Title
  
  Forum on Immunopathological Diseases and Therapeutics
  
  Volume: 4 Pages: 43-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24310167
[Journal Article] Boronic acid inhibitors of acyl protein thioesterase 1 and 22013
- Author(s)
  Zimmermann, T.J., Burger, M., Tashiro, E., Kondoh, Y., Martinez, N.E., Gormer, K., Rosin-steiner, S., Shimizu, T. Ozaki, S., Mikoshiba, K., Watanabe, N., Hall, D., Vetter, I.R., Osada, H., Hedberg, C., & Waldmann, H
- Journal Title
  
  ChemBioChem
  
  Volume: 14 Issue: 1 Pages: 115-122
- DOI
  10.1002/cbic.201200571
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20113008, KAKENHI-PROJECT-20220007, KAKENHI-PROJECT-23510287, KAKENHI-PROJECT-24510320
[Journal Article] Structure-activity relationship Of 9-methylstreptimidone that induces selective apoptosis in adult T-cell leukemia cells2012
- Author(s)
  M.Takeiri, S.Simizu, K.Umezawa, et al
- Journal Title
  
  Oncology Res.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Involvement of DNA binding domain in the cellular stability and importin affinity of NF-κB component RelB2012
- Author(s)
  Takeiri, M., Horie, K., Takahashi, D., Watanabe, M., Horie, R., Simizu, S. & Umezawa, K
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 10 Issue: 15 Pages: 3053-3059
- DOI
  10.1039/c2ob07104e
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20113008, KAKENHI-PROJECT-23590432, KAKENHI-PROJECT-23590433
[Journal Article] Determination of cathepsin V activity and intracellular trafficking by N-glycosylation2012
- Author(s)
  Niwa, Y., Suzuki, T., Dohmae, N., Umezawa, K. & Simizu, S
- Journal Title
  
  FEBS Letters
  
  Volume: 586 Issue: 20 Pages: 3601-3607
- DOI
  10.1016/j.febslet.2012.08.001
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20113008, KAKENHI-PROJECT-24310167
[Journal Article] Suppression of cellular invasion by glybenclamide through inhibited secretion of platelet-derived growth factor in ovarian clear cell carcinoma ES-2 cells2012
- Author(s)
  T. Yasukagawa, Y. Niwa, S. Simizu and K. Umezawa
- Journal Title
  
  FEBS Lett.
  
  Volume: 586
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] ErbB receptor tyrosine kinase/NF-κB signaling controls mammosphere formation in human breast cancer2012
- Author(s)
  K. Hinohara, S. Kobayashi, S. Simizu, K. Tada, E. Tsuji, K. Nishioka, K. Umezawa, M. Mori, H. Kanauchi, T. Ogawa, J. Inoue, A. T and N. Gotoh
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 109 Pages: 6584-6589
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Protein disulfide isomerase-mediated disulfide bonds regulate the gelatinolytic activity and secretion of matrix metalloproteinase-92012
- Author(s)
  Khan, M. G. M., Simizu, S., Suzuki, T., Masuda, A., Muroi, M., Kawatani, M., Dohmae, N. & Osada, H
- Journal Title
  
  Experimental Cell Research
  
  Volume: 318 Issue: 8 Pages: 904-914
- DOI
  10.1016/j.yexcr.2012.02.021
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20113008, KAKENHI-PROJECT-22681034
[Journal Article] Involvement of NF-κB-mediated expression of galectin-3-binding protein in tumor necrosis factor-α-induced breast cancer cell adhesion2012
- Author(s)
  N. Noma, S. Simizu, Y. Kambayashi, Y. Kabe, M. Suematsu, and K. Umezawa
- Journal Title
  
  Oncology Reports
  
  Volume: 27 Pages: 2080-2084
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Suppression of cellular invasion by glybenclamide through inhibited secretion of platelet-derived growth factor in ovarian clear cell carcinoma ES-2 cells2012
- Author(s)
  Yasukagawa, T., Niwa, Y., Simizu, S. & Umezawa, K
- Journal Title
  
  FEBS Letters
  
  Volume: 586 Issue: 10 Pages: 1504-1509
- DOI
  10.1016/j.febslet.2012.04.007
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20113008, KAKENHI-PROJECT-24310167
[Journal Article] Involvement of DNA binding domain in the cellular stability and importin affinity of NF-κB component RelB2012
- Author(s)
  M. Takeiri, K. Horie, D. Takahashi, M. Watanabe, R. Horie, S. Simizu and K. Umezawa
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 10 Pages: 3053-3059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Inhibition of lysenin-induced hemolysis by all-E-lutein derived from the plant Dalbergia latifolia2012
- Author(s)
  Niwa, Y., Matsui, C., Sukumwang, N., Iinuma, H., Ikeda, Y., Koyano, T., Kovitayakorn, T., Simizu, S. & Umezawa, K
- Journal Title
  
  Planta Medica
  
  Volume: 78 Issue: 10 Pages: 957-961
- DOI
  10.1055/s-0031-1298538
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20113008, KAKENHI-PROJECT-24310167
[Journal Article] Suppression of cellular invasion by glybenclamide through inhibited secretion of platelet-derived growth factor in ovarian clear cell carcinoma ES-2 cells2012
- Author(s)
  T. Yasukagawa, Y. Niwa, S. Simizu and K. Umezawa
- Journal Title
  
  FEBS Lett
  
  Volume: 586 Pages: 1504-1509
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Structure-activity relationship of 9-methylstreptimidone that induces selective apoptosis in adult T-cell leukemia cells2012
- Author(s)
  M. Takeiri, E. Ota, S. Nishiyama, H. Kiyota, S. Simizu and K. Umezawa
- Journal Title
  
  Oncology Res.
  
  Volume: 20 Pages: 7-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Involvement of NF-κB-mediated expression of galectin-3-binding protein in tumor necrosis factor-α-induced brest cancer cell adhesion2012
- Author(s)
  Noma, N., Simizu, S., Kambayashi, Y., Kabe, Y., Suematsu, M. & Umezawa, K
- Journal Title
  
  Oncology Reports
  
  Volume: 27 Pages: 2080-2084
- DOI
  10.3892/or.2012.1733
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20113008, KAKENHI-PROJECT-23310163
[Journal Article] Involvement of DNA binding domain in the cellular stability and importin affinity of NF-κB component RelB2012
- Author(s)
  M. Takeiri, K. Horie, D. Takahashi, M. Watanabe, R. Horie, S. Simizu and K. Umezawa
- Journal Title
  
  Org. Biomol. Chem
  
  Volume: 10 Pages: 3053-3059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Development of a vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structure2011
- Author(s)
  Hirai, G., Tsuchiya, A., Koyama, Y., Otani, Y., Oonuma, K., Dodo, K., Simizu, S., Osada, H. & Sodeoka, M
- Journal Title
  
  ChemMedChem
  
  Volume: 6 Issue: 4 Pages: 617-622
- DOI
  10.1002/cmdc.201100107
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20113008, KAKENHI-PROJECT-23790006
[Journal Article] Discovery of a small molecule PDI inhibitor that inhibits reduction of HIV-1 envelope glycoprotein gp1202011
- Author(s)
  Khan, M. G. M., Simizu, S., Lai, N. S., Kawatani, M., Shimizu, T. & Osada, H
- Journal Title
  
  ACS Chemical Biology
  
  Volume: 6 Issue: 3 Pages: 245-251
- DOI
  10.1021/cb100387r
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20113008
[Journal Article] Inhibition of autophagy potentiates the antitumor effect of the multikinase inhibitor sorafenib in hepatocellular carcinoma2011
- Author(s)
  Shimizu S, Takehara T, Hikita H, Kodama T, Tsunematsu H, Miyagi T, Hosui A, Ishida H, Tatsumi T, Kanto T, Hiramatsu N, Fujita N, Yoshimori T, Hayashi N
- Journal Title
  
  Int.J.Cancer
  
  Volume: 131 Issue: 3 Pages: 548-57
- DOI
  10.1002/ijc.26374
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22020023, KAKENHI-PROJECT-22590729, KAKENHI-PROJECT-22770194, KAKENHI-PROJECT-23247034, KAKENHI-PROJECT-23390197, KAKENHI-PROJECT-23657129, KAKENHI-ORGANIZER-20113001, KAKENHI-PLANNED-20113002
[Journal Article] 化合物アレイを起点としたケミカルバイオロジー化合物アレイの基盤技術開発から機能未知タンパク質の機能解析まで2011
- Author(s)
  叶直樹、清水史郎
- Journal Title
  
  化学と工業
  
  Volume: 64 Pages: 37-39
- NAID
  10027655880
- Data Source
  KAKENHI-PLANNED-20113008
[Journal Article] Discovery of a small molecule PDI inhibitor that inhibits reduction of HIV-1 envelope glycoprotein gp120.2011
- Author(s)
  Khan, M.G.M., Simizu, S., Lai, N.S., Kawatani, M., Shimizu, T., Osada, H.
- Journal Title
  
  ACS Chem.Biol. 6
  
  Pages: 245-251
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20113008
[Journal Article] A small-molecule inhibitor shows that pirin regulatesmigration of melanoma cells2010
- Author(s)
  Miyazaki I, Simizu S, Okumura H, Takagi S, Osada H
- Journal Title
  
  Nat Chem Biol 6
  
  Pages: 667-673
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-20113001
[Journal Article] Cleavable linker for photo-cross-linked small-molecule affinity matrix.2010
- Author(s)
  Kanoh, N. (8名中1番目), Simizu, S. (8名中6番目), Osada, H. (8名中7番目)
- Journal Title
  
  Bioconjugate Chem. 21
  
  Pages: 182-186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016079
[Journal Article] A small-molecule inhibitor shows that pirin regulates migration of melanoma cells.2010
- Author(s)
  Miyazaki, I., Simizu, S., Okumura, H., Takagi, S., Osada, H.
- Journal Title
  
  Nature Chem.Biol. 6
  
  Pages: 667-673
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20113008
[Journal Article] Involvement of autocrine CXCL12/CXCR4 system in the regulation of ovarian carcinoma cell invasion2010
- Author(s)
  Miyanishi, N., Suzuki, Y., Simizu, S., Kuwabara, Y., Banno, K. & Umezawa, K
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 403 Issue: 1 Pages: 154-159
- DOI
  10.1016/j.bbrc.2010.11.007
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20113008
[Journal Article] Cleavable linker for photo-cross-linked small-molecule affinity matrix2010
- Author(s)
  Kanoh, N., Takayama, H., Honda, K., Moriya, T., Teruya, T., Simizu, S., Osada, H. & Iwabuchi, Y
- Journal Title
  
  Bioconjugate Chemistry
  
  Volume: 21 Issue: 1 Pages: 182-186
- DOI
  10.1021/bc900316q
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20113008
[Journal Article] A small-molecule inhibitor shows that pirin regulates migration of melanoma cells2010
- Author(s)
  Miyazaki, I., Simizu, S., Okumura, H., Takagi, S. & Osada, H
- Journal Title
  
  Nature Chemical Biology
  
  Volume: 6 Issue: 9 Pages: 667-673
- DOI
  10.1038/nchembio.423
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20113008
[Journal Article] Identification of a novel Vpr-binding compound that inhibits HIV-1 multiplication in macrophages by chemical array2010
- Author(s)
  Hagiwara, K., Murakami, T., Xue, G., Shimizu, Y., Takeda, E., Hashimoto, Y., Honda, K., Kondoh, Y., Osada, H., Tsunetsugu-Yokota, Y. & Aida, Y
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 403 Issue: 1 Pages: 40-45
- DOI
  10.1016/j.bbrc.2010.10.107
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20113008
[Journal Article] Polo-like kinase 1 phosphorylates and regulates Bcl-xL during pironetin-induced apoptosis.2009
- Author(s)
  Simizu, S. (7名中2番目), Muroi, M. (7名中3番目), Osada, H. (7名中7番目)
- Journal Title
  
  Oncogene 28
  
  Pages: 107-116
- NAID
  120006385868
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016079
[Journal Article] Structure-affinity relationship study of bleomycins and Shble protein by use of a chemical array2009
- Author(s)
  Miyazaki, I., Okumura, H., Simizu, S., Takahashi, Y., Kanoh, N., Muraoka, Y., Nonomura, Y. & Osada, H
- Journal Title
  
  ChemBioChem
  
  Volume: 10 Issue: 5 Pages: 845-852
- DOI
  10.1002/cbic.200800728
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20113008
[Journal Article] Deamino-hydroxy-phoslactomycin B, a biosynthetic precursor of phoslactomycin, induces myeloid differentiation in HL-60 cells2009
- Author(s)
  Simizu, S., et al.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 383
  
  Pages: 406-410
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016079
[Journal Article] RECK negatively regulates matrix metalloproteinase-9 transcription2009
- Author(s)
  Takagi, S., Simizu, S., Osada, H.
- Journal Title
  
  Cancer Res. 69
  
  Pages: 1502-1508
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18681035
[Journal Article] Structure-affinity relationship study of bleomycins and Shble protein by use of a chemical array.2009
- Author(s)
  Miyazaki, I., Okumura, H., Simizu, S., Takahashi, Y., Kanoh, N., Muraoka, Y., Nonomura, Y., Osada, H.
- Journal Title
  
  ChemBioChem 10
  
  Pages: 845-852
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20113008
[Journal Article] A cell-based screening to detect inhibitors of BRAF signaling pathway2009
- Author(s)
  Asami, Y., Mori, M., Koshino, H., Sekiyama, Y., Teruya, T., Simizu, S., Usui, T., Osada, H.
- Journal Title
  
  J. Antibiot. 62
  
  Pages: 105-107
- NAID
  10030634719
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18681035
[Journal Article] RECK negatively regulates matrix metalloproteinase-9 transcription.2009
- Author(s)
  Simizu, S. (3名中2番目), Osada, H. (3名中3番目)
- Journal Title
  
  Cancer Res. 69
  
  Pages: 1502-1508
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016079
[Journal Article] RECK negatively regulates matrix metalloproteinase-9 transcription2009
- Author(s)
  Takagi, S., Simizu, S. & Osada, H
- Journal Title
  
  Cancer Research
  
  Volume: 69 Issue: 4 Pages: 1502-1508
- DOI
  10.1158/0008-5472.can-08-2635
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20113008
[Journal Article] On-chip fragment-based approach for discovery of high-affinity bivalent inhibitors2009
- Author(s)
  Miyazaki, I., Simizu, S., Ishida, K. & Osada, H
- Journal Title
  
  ChemBioChem
  
  Volume: 10 Issue: 5 Pages: 838-843
- DOI
  10.1002/cbic.200800704
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20113008
[Journal Article] Structure-affinity relationship study of bleomycins and Shble protein by use of a chemical array.2009
- Author(s)
  Simizu, S. (8名中3番目), Kanoh, N. (8名中5番目), Osada, H. (8名中8番目)
- Journal Title
  
  Chembiochem 10
  
  Pages: 845-852
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016079
[Journal Article] Structure-affinity relationship study of bleomycins and Shble protein by use of a chemical array2009
- Author(s)
  Miyazaki, I., Okumura, H., Simizu, S., Takahashi, Y., Kanoh, N., Muraoka, Y., Nonomura, Y., Osada, H.
- Journal Title
  
  Chembiochem 10
  
  Pages: 845-852
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18681035
[Journal Article] Deamino-hydroxy-phoslactomycin B, a biosynthetic precursor of phoslactomycin, induces myeloid differentiation in HL-60 cells.2009
- Author(s)
  Simizu, S. (8名中1番目), Osada, H. (8名中8番目)
- Journal Title
  
  Biochem. Biophys. Res. Commun. 383
  
  Pages: 406-410
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016079
[Journal Article] Deamino-hydroxy-phoslactomycin B, a biosynthetic precursor of phoslactomycin, induces myeloid differentiation in HL-60 cells2009
- Author(s)
  Simizu, S., Teruya, T., Nogawa, T., Aono, H., Ueki, M., Uramoto, M., Kobayashi, Y. & Osada, H
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 383 Issue: 4 Pages: 406-410
- DOI
  10.1016/j.bbrc.2009.04.014
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20113008
[Journal Article] The Stent-Eluting Drugs Sirolimus and Paclitaxel Suppress Healing of the Endothelium by Induction of Autophagy.2009
- Author(s)
  Hayashi Sl, Yamamoto A, You F, Yamashita K, Ikegame Y, Tawada M, Yoshimori T, Shimizu S, Nakashima S.
- Journal Title
  
  Am J Pathol. 175
  
  Pages: 2226-2234
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-20113001
[Journal Article] Polo-like kinase 1 phosphorylates and regulates Bcl-xL during pironetin-induced apoptosis2009
- Author(s)
  Tamura, Y., Simizu, S., Muroi, M., Takagi, S., Kawatani, M., Watanabe, N., Osada, H.
- Journal Title
  
  Oncogene 28
  
  Pages: 107-116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18681035
[Journal Article] On-chip fragment-based approach for discovery of high-affinity bivalent inhibitors.2009
- Author(s)
  Simizu, S. (4名中2番目), Osada, H. (4名中4番目)
- Journal Title
  
  Chembiochem 10
  
  Pages: 838-843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016079
[Journal Article] RECK negatively regulates matrix metalloproteinase-9 transcription.2009
- Author(s)
  Takagi, S., Simizu, S., Osada, H.
- Journal Title
  
  Cancer Res. 69
  
  Pages: 1502-1508
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20113008
[Journal Article] On-chip fragment-based approach for discovery of high-affinity bivalent inhibitors2009
- Author(s)
  Miyazaki, I., Simizu, S., Ishida, K., Osada, H.
- Journal Title
  
  Chembiochem 10
  
  Pages: 838-843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18681035
[Journal Article] Deamino-hydroxy-phoslactomycin B, a biosynthetic precursor of phoslactomycin, induces myeloid differentiation in HL-60 cells2009
- Author(s)
  Simizu, S., et al.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 383
  
  Pages: 406-410
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20113008
[Journal Article] 分子細胞学的解析2009
- Author(s)
  清水史郎, 辻田和彦, 長田裕之
- Journal Title
  
  日本臨牀 67増刊号1
  
  Pages: 143-147
- Data Source
  KAKENHI-PROJECT-18681035
[Journal Article] A cell-based screening to detect inhibitors of BRAF signaling pathway2009
- Author(s)
  Asami, Y., Mori, M., Koshino, H., Sekiyama, Y., Teruya, T., Simizu, S., Usui, T. & Osada, H
- Journal Title
  
  Journal of Antibiotics
  
  Volume: 62 Issue: 2 Pages: 105-107
- DOI
  10.1038/ja.2008.17
- NAID
  10030634719
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20113008
[Journal Article] Polo-like kinase 1 phosphorylates and regulates Bcl-xL during pironetin-induced apoptosis2009
- Author(s)
  Tamura, Y., Simizu, S., Muroi, M., Takagi, S., Kawatani, M., Watanabe, N. & Osada, H
- Journal Title
  
  Oncogene
  
  Volume: 28 Issue: 1 Pages: 107-116
- DOI
  10.1038/onc.2008.368
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20113008
[Journal Article] Robust and systematic drug screening method using chemical arrays and the protein library:identification of novel inhibitors of carbonic anhydrase II.2008
- Author(s)
  Miyazaki, I., Simizu, S., Ichimiya, H., Kawatani, M., Osada, H.
- Journal Title
  
  Biosci.Biotechnol.Biochem. 72
  
  Pages: 2739-2749
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20113008
[Journal Article] Requirement of the conserved, hydrophobic C-terminus region for the activation of heparanase2008
- Author(s)
  Lai, N. S., Simizu, S., Morisaki, D., Muroi, M. & Osada, H
- Journal Title
  
  Experimental Cell Research
  
  Volume: 314 Issue: 15 Pages: 2834-2845
- DOI
  10.1016/j.yexcr.2008.07.004
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20113008
[Journal Article] 分子細胞学的解析2008
- Author(s)
  清水史郎, 他
- Journal Title
  
  日本臨牀増刊号1 がん薬物療法学 67
  
  Pages: 143-147
- Data Source
  KAKENHI-PROJECT-18681035
[Journal Article] 分子細胞学的解析2008
- Author(s)
  清水史郎他
- Journal Title
  
  日本臨牀増刊号1 がん薬物療法学 67
  
  Pages: 143-147
- Data Source
  KAKENHI-PLANNED-20113008
[Journal Article] Robust and systematic drug screening method using chemical arrays and the protein library: identification of novel inhibitors of carbonic anhydrase II2008
- Author(s)
  Miyazaki, I., Simizu, S., Ichimiya, H., Kawatani, M. & Osada, H
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 72 Pages: 2739-2749
- NAID
  10027533381
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/18838795
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20113008
[Journal Article] Requirement of the conserved, hydrophobic C-terminus region for the activation of heparanase2008
- Author(s)
  Lai, N. S., Simizu, S., Morisaki, D., Muroi, M., Osada, H.
- Journal Title
  
  Exp. Cell Res. 314
  
  Pages: 2834-2845
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18681035
[Journal Article] Requirement of the conserved, hydrophobic C-terminus region for the activation of heparanase.2008
- Author(s)
  Simizu, S. (5名中2番目), Osada, H. (5名中5番目)
- Journal Title
  
  Exp. Cell Res 314
  
  Pages: 2834-2845
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016079
[Journal Article] Synthesis and biological activities of reveromycin A and spirofungin A derivatives.2008
- Author(s)
  Shimizu T., et al.
- Journal Title
  
  Bioorg. Med. Chem. Lett. 18
  
  Pages: 3576-3760
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016079
[Journal Article] Robust and systematic drug screening method using chemical arrays and the protein library : identification of novel inhibitors of carbonic anhydrase II2008
- Author(s)
  Miyazaki, I., Simizu, S., Ichimiya, H., Kawatani, M., Osada, H.
- Journal Title
  
  Biosci. Biotechnol. Biochem. 72
  
  Pages: 2739-2749
- NAID
  10027533381
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18681035
[Journal Article] Involvement of disulfide bond formation in the activation of heparanase.2007
- Author(s)
  Simizu, S. (7名中1番目), Muroi, M. (7名中3番目), Osada, H. (7名中7番目)
- Journal Title
  
  Cancer Res. 67
  
  Pages: 7841-7849
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016079
[Journal Article] Involvement of disulfide bond formation in the activation of heparanase2007
- Author(s)
  Simizu, S., Suzuki, T., Muroi, M., Lai, N. S., Takagi, S., Dohmae, N., Osada, H.
- Journal Title
  
  Cancer Res. 67
  
  Pages: 7841-7849
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18681035
[Journal Article] バイオプローブ開発からケミカルバイオロジー研究へ2007
- Author(s)
  清水史郎, 長田裕之
- Journal Title
  
  化学工業 58
  
  Pages: 335-339
- Data Source
  KAKENHI-PROJECT-18681035
[Journal Article] Synthesis of (+)-vinblastine and its analogues2007
- Author(s)
  Miyazaki, T., Yokoshima, S., Simizu, S., Osada, H., Tokuyama, H., Fukuyama, T.
- Journal Title
  
  Org. Lett. 9
  
  Pages: 4737-4740
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18681035
[Journal Article] Involvement of disulfide bond formation in the activation of heparanase2007
- Author(s)
  Simizu, S., et. al.
- Journal Title
  
  Cancer Research 67
  
  Pages: 7841-7849
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18681035
[Journal Article] Involvement of disulfide bond formation in the activation of heparanase.2007
- Author(s)
  Simizu S., et. al.
- Journal Title
  
  Cancer Res. 67
  
  Pages: 7841-7849
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016079
[Journal Article] Photo-cross-linked small-molecule microarrays as chemical genomic tools for dissecting protein-ligand interactions2006
- Author(s)
  Kanoh, N., Asami, A., Kawatani, M., Honda, K., Kumashiro, S., Takayama, H., Simizu, S., Amemiya, T., Kondoh, Y., Hatakeyama, S., Tsuganezawa, K., Utata, R., Tanaka, A., Yokoyama, S., Tashiro, H., Osada, H.
- Journal Title
  
  Chem. Asian J. 1
  
  Pages: 787-797
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18681035
[Journal Article] Photo-cross-linked small-molecule affinity matrix for facilitating forward and reverse chemical genetics2005
- Author(s)
  Kanoh, N., Honda, K., Simizu, S., Muroi, M., Osada, H.
- Journal Title
  
  Angewandte Chemie International Edition 44
  
  Pages: 3559-3562
- Data Source
  KAKENHI-PROJECT-16710164
[Journal Article] Phoslactomycin targets cysteine-269 of the protein phosphatase 2A catalytic subunit in cells2005
- Author(s)
  Teruya, T., Simizu, S., Kanoh, N., Osada, H.
- Journal Title
  
  FEBS Letters 579
  
  Pages: 2463-2468
- Data Source
  KAKENHI-PROJECT-16710164
[Journal Article] RECK-mediated suppression of tumor cell invasion is regulated by glycosylation in human tumor cell lines.2005
- Author(s)
  Simizu, S. (4名中1番目), Osada, H. (4名中4番目)
- Journal Title
  
  Cancer Res. 65
  
  Pages: 7455-7461
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016079
[Journal Article] RECK-mediated suppression of tumor cell invasion is regulated by glycosylation in human tumor cell lines.2005
- Author(s)
  S.Simizu et al.
- Journal Title
  
  Cancer Res. 65
  
  Pages: 7455-7461
- Data Source
  KAKENHI-PROJECT-17016079
[Journal Article] Phoslactomycin targets cysteine-269 of the protein phosphatase 2A catalytic subunit in cells.2005
- Author(s)
  Simizu, S. (4名中2番目), Kanoh, N. (4名中3番目), Osada, H. (4名中4番目)
- Journal Title
  
  FEBS Lett. 579
  
  Pages: 2463-2468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016079
[Journal Article] Photo-crosslinked small molecule affinity matrix for facilitating forward and reverse chemical genetics.2005
- Author(s)
  Kanoh, N. (5名中1番目), Simizu, S. (5名中3番目), Muroi, M. (5名中4番目), Osada, H. (5名中5番目)
- Journal Title
  
  Angew. Chem. Int. Ed. 44
  
  Pages: 3559-3562
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016079
[Journal Article] RECK-mediated suppression of tumor cell invasion is regulated by glycosylation in human tumor cell lines.2005
- Author(s)
  Simizu, S., Takagi, S., Tamura, Y., Osada, H.
- Journal Title
  
  Cancer Research 65
  
  Pages: 7455-7461
- Data Source
  KAKENHI-PROJECT-16710164
[Journal Article] The phosphorylation status and anti-apoptotic activity of Bcl-2 are regulated by ERK and protein phosphatase 2A on the mitochondria2004
- Author(s)
  Tamura, Y., Simizu, S., Osada, H.
- Journal Title
  
  FEBS Letters 569
  
  Pages: 249-255
- Data Source
  KAKENHI-PROJECT-16710164
[Journal Article] Structure-based design of a selective heparanase inhibitor as an antimetastatic agent2004
- Author(s)
  Ishida, K., Hirai, G., Murakami, K., Teruya, T., Simizu S., Sodeoka, M., Osada, H.
- Journal Title
  
  Molecular Cancer Therapeutics 3
  
  Pages: 1069-1077
- Data Source
  KAKENHI-PROJECT-16710164
[Journal Article] Kaurene diterpene induces apoptosis in human leukemia cells partly through a caspase-8-dependent pathway2004
- Author(s)
  Kondoh, M., Suzuki, I., Sato, M., Nagashima, F., Simizu, S., Harada, M., Fujii, M., Osada, H., Asakawa, Y., Watanabe, Y.
- Journal Title
  
  The Journal of Pharmacology and Experimental Therapeutics 311
  
  Pages: 115-122
- Data Source
  KAKENHI-PROJECT-16710164
[Journal Article] Heparanase as a molecular target of cancer chemotherapy2004
- Author(s)
  Simizu, S., Ishida, K., Osada, H.
- Journal Title
  
  Cancer Science 95
  
  Pages: 553-558
- NAID
  10014196678
- Data Source
  KAKENHI-PROJECT-16710164
[Presentation] C-mannosylation: 酵素と基質の探索2021
- Author(s)
  清水史郎
- Organizer
  山口大学大学院医学系研究科薬理学講座・ラボセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] AML既承認薬によるALK阻害剤耐性克服の発見2021
- Author(s)
  水田隼斗、岡田康太郎、竹本愛、丸山航平、清水史郎、藤田直也、片山量平
- Organizer
  文部科学省科学研究費助成事業新学術領域研究「学術研究支援基盤形成」コホート・生体試料支援プラットフォーム　令和２年度若手支援研究成果発表会
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] ケミカルバイオロジー研究による血管擬態解明2021
- Author(s)
  清水史郎
- Organizer
  日本ケミカルバイオロジー学会・産学連携委員会「ケミカルバイオロジーの技術革新」・研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] FGL1におけるグルコシルガラクトシルヒドロキシ化の機構解析2020
- Author(s)
  森研人、鈴木健裕、三浦一輝、堂前直、清水史郎
- Organizer
  日本農芸化学会関東支部会2020年度大会
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] ヒトIsthmin-1のC型糖修飾によるN型糖鎖修飾と分泌の制御2020
- Author(s)
  吉本哲、鈴木健裕、堂前直、清水史郎
- Organizer
  日本農芸化学会関東支部会2020年度大会
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] ADAMTS4におけるC-mannosylationの機能解析2020
- Author(s)
  三浦一輝、鈴木健裕、堂前直、清水史郎
- Organizer
  第39回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] Madangamineの構造活性相関研究および作用機序の解明2020
- Author(s)
  河野紗也香、三浦一輝、佐藤隆章、千田憲孝、清水史郎
- Organizer
  日本農芸化学会関東支部会2020年度大会
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] C型糖修飾によってヒトIsthmin-1のN型糖鎖修飾は制御されている2020
- Author(s)
  吉本哲、片山和洸、鈴木健裕、堂前直、清水史郎
- Organizer
  第39回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] 血管新生阻害剤TNP-470 はヒトがん細胞の血管擬態形成を抑制する2020
- Author(s)
  清水翔太、川原遼太、三浦一輝、清水史郎
- Organizer
  日本がん分子標的治療学会　第24回学術集会
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] FGL1のグルコシルガラクトシルヒドロキシ化とその責任酵素探索2020
- Author(s)
  森研人、鈴木健裕、三浦一輝、堂前直、清水史郎
- Organizer
  第39回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] C-mannosylationがADAMTS4機能に与える影響の解析2020
- Author(s)
  三浦一輝、鈴木健裕、堂前直、清水史郎
- Organizer
  日本農芸化学会関東支部会2020年度大会
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] 乳がん細胞の血管擬態におけるErbB4の機能解析2020
- Author(s)
  川原遼太、清水史郎
- Organizer
  第29回　日本がん転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] Drug sensitivity analysis of the ALK-TKI resistant cells for modeling the resistant mutants emergence2020
- Author(s)
  水田隼斗、大原智子、小池清恵、岩見真吾、清水史郎、藤田直也、片山量平
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] 細胞接着因子CEACAM1による血管擬態形成の抑制2019
- Author(s)
  林聡一郎、長田祥征、三浦一輝、清水史郎
- Organizer
  日本がん分子標的治療学会　第23回学術集会
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] 低分子化合物による細胞機能の解析2019
- Author(s)
  清水史郎
- Organizer
  特別講義　長浜バイオ大学
- Invited
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] Involvement of C-mannosylation of Isthmin-1 in the its secretion2019
- Author(s)
  Siro Simizu, Satoshi Yoshimoto, Kazuhiro Katayama, Takehiro Suzuki, Kazuki Miura, Naoshi Dohmae
- Organizer
  25th International Symposium on Glycoconjugates
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] Fibrinogen C-terminal domainにおけるC型糖鎖修飾の発見2019
- Author(s)
  長田祥征、水田隼斗、森研人、鈴木健裕、三浦一輝、堂前直、清水史郎
- Organizer
  日本農芸化学会関東支部会2019年度大会
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] Elucidation of the novel biological activities and molecular target of vibsanin A analog2019
- Author(s)
  Kazuki Miura, Siro Simizu
- Organizer
  The 10th Japan-Korea Chemical Biology Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] C型糖修飾によるIsthmin-1への影響2019
- Author(s)
  吉本哲、片山和洸、鈴木健裕、三浦一輝、堂前直、清水史郎
- Organizer
  第38回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] 血管擬態形成はCEACAM1によって制御される2019
- Author(s)
  清水史郎、林聡一郎
- Organizer
  第28回　日本がん転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] FGL1のグルコシルガラクトシルヒドロキシ化が機能に及ぼす影響2019
- Author(s)
  森研人、鈴木健裕、三浦一輝、堂前直、清水史郎
- Organizer
  第38回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] ヒトがん細胞においてMFAP4はC型糖修飾を受ける2019
- Author(s)
  長田祥征、鈴木健裕、三浦一輝、堂前直、清水史郎
- Organizer
  第38回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] Microfibril-associated glycoprotein 4 is C-mannosylated in human cells2019
- Author(s)
  Yushiyuki Osada, Takehiro Suzuki, Kazuki Miura, Naoshi Dohmae, Siro Simizu
- Organizer
  25th International Symposium on Glycoconjugates
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] C-mannosylation: identification of novel enzymes and substrates2019
- Author(s)
  Siro Simizu
- Organizer
  The 7th Symposium RIKEN-Max Planck Joint Research Center
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] Vibsanin Aの構造活性相関とその誘導体が持つ新規生物活性の評価2019
- Author(s)
  三浦一輝、松木渉、高尾賢一、清水史郎
- Organizer
  日本ケミカルバイオロジー学会　第14回年会
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] Vibsanin A誘導体の新規生物活性評価および作用標的の同定2019
- Author(s)
  三浦一輝、松木渉、高尾賢一、清水史郎
- Organizer
  日本農芸化学会関東支部会2019年度大会
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] RAMP1 is C-mannosylated at Trp56 in cultured human cells2019
- Author(s)
  Hayato Mizuta, Ayane Takakusaki, Takehiro Suzuki, Keisuke Otake, Kazuki Miura, Naoshi Dohmae, Siro Simizu
- Organizer
  25th International Symposium on Glycoconjugates
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] ヒト死後脳の神経細胞におけるLINE-1プロモーターのエピジェネティック修飾状態の検討2019
- Author(s)
  渡邊理紗、文東美紀、上田順子、村田唯、石井貴男、鵜飼渉、橋本恵理、笠井清登、清水史郎、加藤忠史、岩本和也
- Organizer
  第41回日本生物学的精神医学会
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] Cytosporolide C and its analog inhibited activities of topoisomerases and tumor cell growth2019
- Author(s)
  川原遼太、清水史郎
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] インテグリンβ1は血管擬態形成に重要な因子である2018
- Author(s)
  川原遼太、丹羽祐貴、清水史郎
- Organizer
  第27回　日本がん転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] CCN1におけるglucosyl-galactosyl-hydroxylationの機能解析2018
- Author(s)
  石沢雄大、丹羽祐貴、鈴木健裕、堂前直、清水史郎
- Organizer
  第37回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] C-mannosylationによるR-spondin2 の機能制御2018
- Author(s)
  水田隼斗、丹羽祐貴、堂前直、清水史郎
- Organizer
  日本がん分子標的治療学会　第22回学術集会
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] R-spondin1 におけるリン酸化の機能解析2018
- Author(s)
  西谷拓海, 鈴木健裕, 丹羽祐貴, 三浦一輝, 堂前直, 清水史郎
- Organizer
  日本農芸化学会関東支部会2018年度大会
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] Cytosporolide類の細胞増殖抑制活性における責任分子標的の同定2018
- Author(s)
  大竹慶祐、室井誠、丹羽祐貴、宮嵜奏、笹澤有紀子、長田裕之、清水史郎
- Organizer
  日本がん分子標的治療学会　第22回学術集会
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] Identification of molecular targets on inhibitory activity of cell proliferation by cytosporolide analogs2018
- Author(s)
  Keisuke Otake, Makoto Muroi, Yuki Niwa, Ken-ichi Takao, Hiroyuki Osada, Siro Simizu
- Organizer
  The 9th Japan-Korea Chemical Biology Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] トポロジー解析によるDPY19L1活性中心の探索2018
- Author(s)
  横山典弘、柳原　凌太郎、小松　良亮、三浦　一輝、丹羽祐貴、清水史郎
- Organizer
  第37回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] トポロジー解析によるDPY19L1のC-mannosyltransferase活性中心の探索2018
- Author(s)
  横山典弘, 柳原凌太郎, 三浦一輝, 丹羽祐貴, 清水史郎
- Organizer
  日本農芸化学会関東支部会2018年度大会
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] Functional analysis of the promoter region of C-mannosyltransferase DPY19L32018
- Author(s)
  Satoshi Yoshimoto, Siro Simizu
- Organizer
  29th International Carbohydrate Symposium in 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] ヒトC型糖転移酵素DPY19L3のプロモーター解析2018
- Author(s)
  吉本哲、三浦一輝、清水史郎
- Organizer
  日本農芸化学会関東支部会2018年度大会
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] C-mannosylation－基質と酵素の探索2018
- Author(s)
  清水史郎
- Organizer
  日本農芸化学会中部支部第183回例会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] Vibsanin A誘導体の生物活性評価および標的分子の同定2018
- Author(s)
  三浦一輝、松木渉、高尾賢一、清水史郎
- Organizer
  日本農芸化学会関東支部会2018年度大会
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] C-mannosylation of R-spondin2 as a potential cancer biomarker2018
- Author(s)
  水田隼斗、丹羽祐貴、清水史郎
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] Glucosy-galactosyl-hydroxylation of CCN1 regulates its secretion2018
- Author(s)
  Yudai Ishizawa, Yuki Niwa, Takehiro Suzuki, Naoshi Dohmae, Siro Simizu
- Organizer
  29th International Carbohydrate Symposium in 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06137
[Presentation] Identification of a compound that regulates autophagy in cells2015
- Author(s)
  Siro Simizu
- Organizer
  International Mini Symposium on Chemical Biology of Natural Products
- Place of Presentation
  慶應義塾大学（神奈川県・横浜市）
- Year and Date
  2015-03-24
- Invited
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] Regulation of Wnt signaling by glycosylation2014
- Author(s)
  Siro Simizu
- Organizer
  Universiti Sains Malaysia Public Lecture
- Place of Presentation
  Penang, Malaysia
- Invited
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] 新規alkylglutarimide化合物による成人T細胞白血病細胞のNF-kappa B阻害と選択的アポトーシス誘導2013
- Author(s)
  宇梶　珠未、竹入　雅敏、伊藤あゆみ、清水史郎、梅澤一夫
- Organizer
  日本癌学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] Secretion of R-spondin1 is regulated by C-mannosylation2013
- Author(s)
  Yuki Niwa, Siro Simizu
- Organizer
  AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
- Place of Presentation
  Boston, MA; USA
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] Involvement of glycosylation in hyaluronidase1 functions2013
- Author(s)
  Siro Simizu, Yuki Goto, Yuki Niwa
- Organizer
  9th International Conference on Hyaluronan
- Place of Presentation
  Oklahoma City, OK; USA
- Invited
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] Induction of NF-kappa B and induction of selective apoptosis by novel alkylglutarimide compounds in adult T-cell leukemia cells2013
- Author(s)
  宇梶珠未、竹入雅敏、伊藤あゆみ、清水史郎、梅澤一夫
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] Regulation of R-spondin1 secretion by C-mannosylation2013
- Author(s)
  丹羽祐貴、清水史郎
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] Role of glycosylation on Hyaluronidase1 functions2013
- Author(s)
  後藤祐貴、丹羽祐貴、清水史郎
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] 細胞内ロジスティクス研究におけるケミカルバイオロジーの役割2013
- Author(s)
  清水史郎
- Organizer
  新学術領域研究「細胞内ロジスティクス」終了シンポジウム
- Place of Presentation
  淡路島
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] 海洋産マクロリドBiselyngbyaside類の構造と生物活性2013
- Author(s)
  森田真布、大野修、矢守隆夫、丹羽祐貴、清水史郎、末永聖武
- Organizer
  日本農芸化学会関東支部会2013年度大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] Conophyllineによるオートファジー誘導2013
- Author(s)
  笹澤有紀子、梅澤一夫、清水史郎
- Organizer
  日本ケミカルバイオロジー学会　第8回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] NF-κB阻害剤(-)-DHMEQはMMP-2依存性のマスト細胞浸潤を抑制する2013
- Author(s)
  野間成人、清水史郎、梅澤一夫
- Organizer
  第17回がん分子標的治療学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] Suppression of NO-induced beta cell death by (-)-DHMEQ via activation of Nrf2-ARE pathway and alteration of MAPK activity2013
- Author(s)
  K. Umezawa, T. Ukaji, A. Ogasawara, S. Simizu and I. Takei
- Organizer
  49th Annual European Association for the Study of Diabetes (EASD) Meeting 2013
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] R-spondin1の機能に与えるC-mannosylationの役割2013
- Author(s)
  丹羽祐貴、清水史郎
- Organizer
  第22回　日本がん転移学会学術集会・総会
- Place of Presentation
  松本
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] TPh A 誘導体の破骨細胞分化に及ぼす影響と構造活性相関解析2013
- Author(s)
  森下佳典、笹澤有紀子、杉野公美、川谷誠、長田裕之、清水史郎
- Organizer
  日本農芸化学会関東支部会2013年度大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] Neuroprotective effect of conophylline in cellular model of Parkinson’s disease2013
- Author(s)
  Yukiko Sasazawa, Kazuo Umezawa, Siro Simizu
- Organizer
  International Symposium on Mitochondria 2013
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] Conophylline標的タンパク質ARL6ip1の小胞体におけるトポロジー解析2013
- Author(s)
  黒田将広、宇梶珠未、笹澤有紀子、清水史郎
- Organizer
  日本ケミカルバイオロジー学会　第8回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] オートファジーを制御する新規化合物の探索2013
- Author(s)
  田中敦史、近藤恭光、清水史郎、斎藤臣雄、長田裕之、野田健司、吉森保
- Organizer
  第65回　日本細胞生物学会大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] NF-kappa B阻害剤(-)-DHMEQはMMP-2依存性のマスト細胞浸潤を抑制する2013
- Author(s)
  野間成人、清水史郎、梅澤一夫
- Organizer
  日本がん分子標的治療学会　第16回学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] Hyaluronidase1 activity and secretion are regulated by C-mannosylation2013
- Author(s)
  Simizu, S., et al.
- Organizer
  9th AACRJCA Joint Conference
- Place of Presentation
  Hyatt Regency Maui (アメリカ)
- Year and Date
  2013-02-24
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] Hyaluronidase1 activity and secretion are regulated by C-mannosylation2013
- Author(s)
  Simizu, S., et al.
- Organizer
  9th AACR-JCA Joint Conference
- Place of Presentation
  Hyatt Regency Maui（アメリカ）
- Year and Date
  2013-02-24
- Data Source
  KAKENHI-PLANNED-20113008
[Presentation] Hyaluronidase1 activity and secretion are regulated by C-mannosylation2013
- Author(s)
  Simizu, S., et al.
- Organizer
  9th AACR-JCA Joint Conference
- Place of Presentation
  Hyatt Regency Maui、アメリカ
- Year and Date
  2013-02-24
- Data Source
  KAKENHI-PLANNED-20113008
[Presentation] conophyllineによる神経保護効果の解2013
- Author(s)
  笹澤有紀子、梅澤一夫、清水史郎
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] がん分子標的研究の今昔2012
- Author(s)
  清水史郎
- Organizer
  理研セミナー
- Place of Presentation
  理化学研究所、埼玉県
- Year and Date
  2012-07-13
- Data Source
  KAKENHI-PLANNED-20113008
[Presentation] がん分子標的研究の今昔2012
- Author(s)
  清水史郎
- Organizer
  理研セミナー
- Place of Presentation
  理化学研究所(埼玉県)(招待講演)
- Year and Date
  2012-07-13
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] DTCM-glutarimideによる成人T細胞白血病におけるRelBの分解とアポトーシス誘導2012
- Author(s)
  伊藤あゆみ，清水史郎、梅澤一夫
- Organizer
  日本癌学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] Inhibition of canonical and noncanonical NF-κBs by (-)-DHMEQ2012
- Author(s)
  K. Horie, K. Sidthipong, M. Takeiri, S. Simizu, and K. Umezawa
- Organizer
  The 17th World Congress on Advances in Oncology, and 15th International Symposium on Molecular Medicine
- Place of Presentation
  Crete, Greece
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] がん分子標的研究の今昔2012
- Author(s)
  清水史郎
- Organizer
  理研セミナー
- Place of Presentation
  理化学研究所（埼玉県）
- Year and Date
  2012-07-13
- Invited
- Data Source
  KAKENHI-PLANNED-20113008
[Presentation] Regulation of melanoma cell migration by Pirin revealed by an approach of chemical biology2011
- Author(s)
  清水史郎、長田裕之
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場:名古屋(招待講演)
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PLANNED-20113008
[Presentation] (-)-DHMEQによるnoncanonical NF-kappa Bの新規阻害機構2011
- Author(s)
  竹入雅敏、清水史郎、梅澤一夫, ほか
- Organizer
  日本ケミカルバイオロジー学会
- Place of Presentation
  神奈川
- Year and Date
  2011-05-23
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] ケミカルバイオロジーと細胞内ロジスティクス研究の融合2011
- Author(s)
  清水史郎、長田裕之
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  国立京都国際会館:京都(招待講演)
- Year and Date
  2011-09-21
- Data Source
  KAKENHI-PLANNED-20113008
[Presentation] Protein disulfide isomeraseによるMMP-9の活性化機構の解析2011
- Author(s)
  清水史郎
- Organizer
  第20回日本がん転移学会学術集会
- Place of Presentation
  アクトシティ浜松:浜松
- Year and Date
  2011-07-01
- Data Source
  KAKENHI-PLANNED-20113008
[Presentation] Galectin-3 binding proteinの作用と発現におけるNF-κBの関与。Regulation of Galectin-3 binding protein expression by NF-kappa B2011
- Author(s)
  野間成人、清水史郎、梅澤一夫
- Organizer
  日本分子標的がん治療学会
- Place of Presentation
  東京
- Year and Date
  2011-06-22
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] 化合物アレイを用いたタンパク質阻害剤の網羅的探索2011
- Author(s)
  清水史郎、長田裕之
- Organizer
  日本薬学会第131回年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PLANNED-20113008
[Presentation] 化合物アレイを用いたタンパク質阻害剤の網羅的探索2011
- Author(s)
  清水史郎、長田裕之
- Organizer
  日本薬学会第131回年会
- Place of Presentation
  ツインメッセ静岡、静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PLANNED-20113008
[Presentation] Pirin によるメラノーマ細胞の遊走制御と阻害剤探索2010
- Author(s)
  清水史郎
- Organizer
  第19回日本がん転移学会学術集会
- Place of Presentation
  金沢
- Year and Date
  2010-06-16
- Data Source
  KAKENHI-PLANNED-20113008
[Presentation] Pirinによるメラノーマ細胞の遊走制御と阻害剤探索2010
- Author(s)
  清水史郎
- Organizer
  第19回日本がん転移学会学術集会・総会
- Place of Presentation
  金沢市文化ホール:金沢市
- Year and Date
  2010-06-16
- Data Source
  KAKENHI-PLANNED-20113008
[Presentation] A small molecule inhibitor of Pirin that suppresses tumor cell migration.2009
- Author(s)
  Simizu, S.
- Organizer
  2009 AACR-NCI-EORTC International Conference
- Place of Presentation
  Boston, U.S. A
- Data Source
  KAKENHI-PROJECT-17016079
[Presentation] 最先端創薬システム:分子標的治療薬開発のためのケミカルバイオロジー2009
- Author(s)
  清水史郎
- Organizer
  第13回日本がん分子標的治療学会学術集会
- Place of Presentation
  ホテルクレメント徳島(徳島)
- Year and Date
  2009-06-25
- Data Source
  KAKENHI-PROJECT-17016079
[Presentation] 化合物アレイを用いた抗がん剤スクリーニング系の開発2009
- Author(s)
  清水史郎, 他
- Organizer
  第13回日本がん分子標的治療学会学術集会
- Place of Presentation
  ホテルクレメント徳島:徳島市
- Year and Date
  2009-06-26
- Data Source
  KAKENHI-PLANNED-20113008
[Presentation] Discovery of small-molecule inhibitors by chemical array.2009
- Author(s)
  清水史郎, 他
- Organizer
  RIKEN 2009 Joint retreat
- Place of Presentation
  熱海ニューフジヤホテル (熱海)
- Data Source
  KAKENHI-PROJECT-17016079
[Presentation] On-chip fragment-based approach for new tool of antitumor drug design2009
- Author(s)
  Miyazaki, I., Simizu, S., Osada, H.
- Organizer
  AACR-ACS Joint Conference on Chemistry in Cancer Research
- Place of Presentation
  アメリカ・ニューオーリンズ
- Year and Date
  2009-02-10
- Data Source
  KAKENHI-PROJECT-18681035
[Presentation] 最先端創薬システム:分子標的治療薬開発のためのケミカルバイオロジー2009
- Author(s)
  清水史郎, 他
- Organizer
  第13回日本がん分子標的治療学会学術集会
- Place of Presentation
  ホテルクレメント徳島:徳島市
- Year and Date
  2009-06-25
- Data Source
  KAKENHI-PLANNED-20113008
[Presentation] 最先端創薬システム:分子標的治療薬開発のためのケミカルバイオロジー2009
- Author(s)
  清水史郎、宮崎功、長田裕之
- Organizer
  第13回日本がん分子標的治療学会学術集会
- Place of Presentation
  徳島
- Year and Date
  2009-06-25
- Data Source
  KAKENHI-PLANNED-20113008
[Presentation] 化合物アレイを使用した抗がん剤のスクリーニング法2009
- Author(s)
  清水史郎, 他
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜:横浜市
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PLANNED-20113008
[Presentation] Establishment of novel antitumor drugs screening method by using chemical array2009
- Author(s)
  Simizu, S., et al.
- Organizer
  AACR-ACS Joint Conference on Chemistry in Cancer Research
- Place of Presentation
  米国 : Westin New Orleans Canal Place
- Data Source
  KAKENHI-PROJECT-18681035
[Presentation] 化合物アレイを用いた抗がん剤スクリーニング法の開発2009
- Author(s)
  清水史郎
- Organizer
  第13回日本がん分子標的治療学会学術集会
- Place of Presentation
  ホテルクレメント徳島(徳島)
- Year and Date
  2009-06-26
- Data Source
  KAKENHI-PROJECT-17016079
[Presentation] 化合物アレイを使用した抗がん剤のスクリーニング法2009
- Author(s)
  清水史郎、宮崎功、長田裕之
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PLANNED-20113008
[Presentation] Establishment of novel antitumor drugs screening method by using chemical array.2009
- Author(s)
  Simizu, S.
- Organizer
  AACR-ACS Joint Conference on Chemistry in Cancer Research
- Place of Presentation
  New Orleans, USA.
- Data Source
  KAKENHI-PROJECT-17016079
[Presentation] 化合物アレイを使用した抗がん剤のスクリーニング法2009
- Author(s)
  清水史郎
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜(横浜)
- Data Source
  KAKENHI-PROJECT-17016079
[Presentation] Establishment of novel antitumor drugs screening method by using chemical array2009
- Author(s)
  Simizu, S., Miyazaki, I., Osada, H.
- Organizer
  AACR-ACS Joint Conference on Chemistry in Cancer Research
- Place of Presentation
  アメリカ、ニューオーリンズ
- Year and Date
  2009-02-09
- Data Source
  KAKENHI-PROJECT-18681035
[Presentation] Establishment of novel antitumor drugs screening method by using chemical array2009
- Author(s)
  Simizu, S., et al.
- Organizer
  AACR-ACS Joint Conference on Chemistry in Cancer Research
- Place of Presentation
  米国 : Westin New Orleans Canal Place
- Data Source
  KAKENHI-PLANNED-20113008
[Presentation] A small molecule inhibitor of Pirin that suppresses tumor cell migration2009
- Author(s)
  清水史郎
- Organizer
  2009 AACR-NCI-EORTC International Conference
- Place of Presentation
  Boston, U.S.A
- Data Source
  KAKENHI-PROJECT-17016079
[Presentation] Establishment of novel antitumor drugsscreening method by using chemical array2009
- Author(s)
  Simizu, S., Miyazaki, I., Osada, H.
- Organizer
  AACR-ACS Joint Conference on Chemistry in Cancer Research
- Place of Presentation
  アメリカ・ニューオリンズ
- Year and Date
  2009-02-09
- Data Source
  KAKENHI-PLANNED-20113008
[Presentation] ヘパラナーゼ結合タンパク質の探索と活性化機構の解析2008
- Author(s)
  清水史郎, 他
- Organizer
  第12回がん分子標的治療研究会
- Place of Presentation
  学術総合センター (東京)
- Data Source
  KAKENHI-PROJECT-17016079
[Presentation] RECK suppressed MMP-9 mRNA due to the decrease of Fra-1 binding to MMP-9 promoter region2008
- Author(s)
  高木聡, 清水史郎, 長田裕之
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-18681035
[Presentation] Activation and function of heparanase: roles of post-translational modifications.2008
- Author(s)
  Simizu, S.
- Organizer
  International Symposium on System Glycobiology
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2008-12-05
- Data Source
  KAKENHI-PROJECT-17016079
[Presentation] GeneライブラリーGLORIAの構築2008
- Author(s)
  一宮治美, 清水史郎, 宮崎功, 長田裕之
- Organizer
  第3回日本ケミカルバイオロジー研究会年会
- Place of Presentation
  東京
- Year and Date
  2008-05-20
- Data Source
  KAKENHI-PROJECT-18681035
[Presentation] Activation and function of heparanase: roles of post-translational modifications2008
- Author(s)
  Simizu, S., et al.
- Organizer
  International Symposium on Systems Glycobiology
- Place of Presentation
  東京 : 東京カンファレンスセンター
- Year and Date
  2008-12-05
- Data Source
  KAKENHI-PLANNED-20113008
[Presentation] ヘパラナーゼ結合タンパク質の探索と活性化機構の解析2008
- Author(s)
  清水史郎, 他
- Organizer
  第12回がん分子標的治療研究会
- Place of Presentation
  東京 : 学術総合センター
- Data Source
  KAKENHI-PROJECT-18681035
[Presentation] Identification of heparanase- interacting proteins of human fibrosarcoma cells2008
- Author(s)
  清水史郎, Lai Ngit Shin, 室井誠, 長田裕之
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-18681035
[Presentation] ヘパラナーゼ結合タンパク質の探索と活性化機構の解析2008
- Author(s)
  清水史郎, Lai Ngit Shin, 室井誠, 長田裕之
- Organizer
  第12回がん分子標的治療研究会
- Place of Presentation
  東京
- Year and Date
  2008-06-26
- Data Source
  KAKENHI-PROJECT-18681035
[Presentation] Activation and function of heparanase: roles of post-translational modifications2008
- Author(s)
  Simizu, S., Lai, N. S., Osada, H.
- Organizer
  International Symposium on Systems Glycobiology
- Place of Presentation
  東京
- Year and Date
  2008-12-05
- Data Source
  KAKENHI-PROJECT-18681035
[Presentation] 化合物アレイスクリーニング系の構築と新規CAIIリガンドの検出2008
- Author(s)
  宮崎功, 清水史郎, 一宮治美, 長田裕之
- Organizer
  第3回日本ケミカルバイオロジー研究会年会
- Place of Presentation
  東京
- Year and Date
  2008-05-19
- Data Source
  KAKENHI-PROJECT-18681035
[Presentation] ヒト線維肉腫細胞株におけるヘパラナーゼ結合タンパク質の探索と同定2008
- Author(s)
  清水史郎, 他
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場 (名古屋)
- Data Source
  KAKENHI-PROJECT-17016079
[Presentation] 理研天然化合物バンク(NPDepo)におけるリガンドスクリーニング2008
- Author(s)
  斎藤臣雄, 米田新, 宮崎功, 清水史郎, 近藤恭光, 松井南, 長田裕之
- Organizer
  日本農芸化学会2008年度大会
- Place of Presentation
  名古屋
- Year and Date
  2008-03-27
- Data Source
  KAKENHI-PROJECT-18681035
[Presentation] ヒト線維肉腫細胞株におけるヘパラナーゼ結合タンパク質の探索と同定2008
- Author(s)
  清水史郎, 他
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  愛知 : 名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-18681035
[Presentation] Activation and function of heparanase: roles of post-translational modifications2008
- Author(s)
  Simizu, S., et al.
- Organizer
  International Symposium on Systems Glycobiology
- Place of Presentation
  東京 : 東京カンファレンスセンター
- Year and Date
  2008-12-05
- Data Source
  KAKENHI-PROJECT-18681035
[Presentation] A novel chemical microarray platform for searching anticancer drugs2007
- Author(s)
  Simizu, S., et. al.
- Organizer
  第66回日本癌学会総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-18681035
[Presentation] Phosphorylation of Bcl-xL by polo-like kinase l results in the inactivation of the anti-apoptotic activity during tubulin binder-induced apoptosis2007
- Author(s)
  Simizu, S., et. al.
- Organizer
  AACR-NCI-EORTC International Conference"Molecular Targets and Cancer Therapeutics"
- Place of Presentation
  Moscone West Convention Center,サンフランシスコ
- Data Source
  KAKENHI-PROJECT-18681035
[Presentation] Phosphorylation of Bcl-xL by polo-like kinase 1 results in the inactivation of the anti-apoptotic activity during tubulin binder-induced apoptosis.2007
- Author(s)
  Simizu, S.
- Organizer
  AACR-NCI-EORTC International Conference "Molecular Targets and Cancer Therapeutics"Discovery, Biology, and Clinical Applications
- Place of Presentation
  Moscone West Convention, Center, San Francisco, USA
- Year and Date
  2007-10-23
- Data Source
  KAKENHI-PROJECT-17016079
[Presentation] Phosphorylation of Bcl-xL by polo-1ike kinase I results inactivation of the anti-apoptotic activity during tubulin binder-induced apoptosis2007
- Author(s)
  Simizu S., et. al.
- Organizer
  AACR-NCI-EORTC International Conference "MolecularTargets and Cancer Therapeutics" Discovery, Biology, and Clinical Applications
- Place of Presentation
  Moscone West Convention Center, San Francisco, USA
- Year and Date
  2007-10-23
- Data Source
  KAKENHI-PROJECT-17016079
[Presentation] RECK suppresses the expression of MMP-9 mRNA in human tumor cells2007
- Author(s)
  高木聡, 清水史郎, 長田裕之
- Organizer
  第66回日本癌学会総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-03
- Data Source
  KAKENHI-PROJECT-18681035
[Presentation] ヘパラナーゼに存在するシステイン残基の修飾とその役割解析2007
- Author(s)
  清水史郎, 室井誠, Lai Ngit Shin, 高木聡, 堂前直, 長田裕之
- Organizer
  第11回がん分子標的治療研究会総会
- Place of Presentation
  大阪
- Year and Date
  2007-07-05
- Data Source
  KAKENHI-PROJECT-18681035
[Presentation] Human heparanase: Activation and inhibition2007
- Author(s)
  Simizu, S.
- Organizer
  15th Proteoglycan Forum
- Place of Presentation
  東京医科歯科大学
- Year and Date
  2007-10-28
- Data Source
  KAKENHI-PROJECT-18681035
[Presentation] A novel chemical microarray platform for searching anticancer drugs2007
- Author(s)
  清水史郎, 宮崎功, 奥村英夫, 叶直樹, 長田裕之
- Organizer
  第66回日本癌学会総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-03
- Data Source
  KAKENHI-PROJECT-18681035
[Presentation] ヘパラナーゼに存在するシステイン残基の修飾とその役割解析2007
- Author(s)
  清水史郎, 他
- Organizer
  第11回がん分子標的治療研究会総会
- Place of Presentation
  大阪国際交流センター
- Data Source
  KAKENHI-PROJECT-18681035
[Presentation] Phosphorylation of Bcl-xL by polo-like kinase 1 results in the inactivation of the anti-apoptotic activity during tubulin binder-induced apoptosis2007
- Author(s)
  Simizu, S., Tamura, Y., Kawatani, M, Watanabe, N., Osada, H.
- Organizer
  AACR-NCI-EORTC International Conference "Molecular Targets and Cancer Therapeutics"
- Place of Presentation
  アメリカ・サンフランシスコ
- Year and Date
  2007-10-23
- Data Source
  KAKENHI-PROJECT-18681035
[Presentation] ヘパラナーゼに存在するシステイン残基の修飾とその役割解析2007
- Author(s)
  清水史郎, 他
- Organizer
  第11回がん分子標的治療研究会総会
- Place of Presentation
  大阪国際交流センター
- Year and Date
  2007-07-05
- Data Source
  KAKENHI-PROJECT-17016079
[Presentation] RECKによるMMP-9 mRNA減少機構の解明2007
- Author(s)
  高木聡, 清水史郎, 長田裕之
- Organizer
  第11回がん分子標的治療研究会総会
- Place of Presentation
  大阪
- Year and Date
  2007-07-05
- Data Source
  KAKENHI-PROJECT-18681035
[Presentation] PP2A特異的阻害剤ホスラクトマイシン類が有するHL60細胞の分化誘導活性2007
- Author(s)
  照屋貴之, 清水史郎, 小林雄一, 長田裕之
- Organizer
  日本農芸化学会2007年度大会
- Place of Presentation
  東京
- Year and Date
  2007-03-25
- Data Source
  KAKENHI-PROJECT-18681035
[Presentation] Human heparanase : Activation and inhibition2007
- Author(s)
  Simizu, S.
- Organizer
  15th Proteoglycan Forum
- Place of Presentation
  東京
- Year and Date
  2007-10-28
- Data Source
  KAKENHI-PROJECT-18681035
[Presentation] A novel chemical microarray platform for searching anticancer drugs2007
- Author(s)
  清水史郎他
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-10-03
- Data Source
  KAKENHI-PROJECT-17016079
[Presentation] 官能基非依存型低分子マイクロアレイとヒト培養細胞抽出物を用いた、タンパク質-低分子リガンド・スクリーニング系の構築2007
- Author(s)
  宮崎功, 清水史郎, 奥村英夫, 叶直樹, 高橋良和, 野々村禎昭, 長田裕之
- Organizer
  第2回日本ケミカルバイオロジー研究会年会
- Place of Presentation
  京都
- Year and Date
  2007-05-10
- Data Source
  KAKENHI-PROJECT-18681035
[Presentation] N-linked glycan which attached Asn354 regulate secretion of Extracellular matrix protein 1
- Author(s)
  Shiho Uematsu, Yuki Goto, Takehiro Suzuki, Yukiko Sasazawa, Naoshi Dohmae, Siro Simizu
- Organizer
  15th International Biennial Congress of the Metastasis Research Society
- Place of Presentation
  Heidelberg（Germany）
- Year and Date
  2014-06-28 – 2014-07-01
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] Secretion of Extracellular matrix protein 1 is regulated by N-glycosylation
- Author(s)
  植松史帆、後藤祐貴、笹澤有紀子、清水史郎
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] Pirin downregulates E-cadherin gene expression and contribute to EMT
- Author(s)
  Kuniya Komai, Yuki Niwa, Yukiko Sasazawa, Siro Simizu
- Organizer
  EORTC-NCI-AACR International Symposium on Molecular Targets and Cancer Therapeutics
- Place of Presentation
  Barcelona（Spain）
- Year and Date
  2014-11-18 – 2014-11-21
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] Human DPY19L3 is a C-mannosyltransferase for R-spondin1 and regulates R-spondin1 secretion
- Author(s)
  丹羽祐貴、清水史郎
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] R-spondin1 functions are regulated by N-glycosylation
- Author(s)
  Miyu Tsuchiya, Yuki Niwa, Siro Simizu
- Organizer
  15th International Biennial Congress of the Metastasis Research Society
- Place of Presentation
  Heidelberg（Germany）
- Year and Date
  2014-06-28 – 2014-07-01
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] C-mannosylationによるR-spondin1の機能制御
- Author(s)
  丹羽祐貴、清水史郎
- Organizer
  第23回　日本がん転移学会学術集会・総会
- Place of Presentation
  金沢市文化ホール（石川県・金沢市）
- Year and Date
  2014-07-10 – 2014-07-11
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] Conophyllineの抗ハンチントン病作用
- Author(s)
  佐藤夏実、笹澤有紀子、梅澤一夫、清水史郎
- Organizer
  日本ケミカルバイオロジー学会　第9回年会
- Place of Presentation
  大阪大学（大阪府・豊中市）
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] Pirin regulates EMT by downregulating E-cadherin gene expression
- Author(s)
  駒井邦哉、丹羽祐貴、笹澤有紀子、清水史郎
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] N-glycosylation regulates R-spondin1 functions
- Author(s)
  土屋みゆ、丹羽祐貴、清水史郎
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] 破骨細胞分化阻害剤の作用機構解析
- Author(s)
  笹澤有紀子、森下佳典、杉野公美、川谷誠、長田裕之、清水史郎
- Organizer
  日本ケミカルバイオロジー学会　第9回年会
- Place of Presentation
  大阪大学（大阪府・豊中市）
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] N型糖鎖修飾がHYAL1機能に与える影響
- Author(s)
  後藤祐貴、丹羽祐貴、堂前直、清水史郎
- Organizer
  日本がん分子標的治療学会　第18回学術集会
- Place of Presentation
  仙台市情報・産業プラザ（宮城県・仙台市）
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] クラビラクトン類縁体の合成
- Author(s)
  茂木拓馬、吉田圭佑、高尾賢一、宮嵜奏、笹澤有紀子、清水史郎
- Organizer
  日本化学会第95春季年会
- Place of Presentation
  日本大学（千葉県・船橋市）
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-24310167

1. KANOH Naoki (40317293)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
2. KONDOH Yasumitsu (80333342)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
3. OSADA Hiroyuki (80160836)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
4. SUDO Tatsuhiko (30260227)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. MUROI Makoto (30261168)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
6. UEKI Masashi (90312264)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. UMEZAWA Kazuo (70114402)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. YOSHIMORI Tamotsu (60191649)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. OHNO Hiroshi (50233226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SASAKI Takuya (40241278)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. IZUMI Tetsuro (00212952)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. FUKUDA Mitsunori (50311361)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. MAKINOUCHI Akitake (80087460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. ISHIKAWA Yuichi (40348826)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. OZAKI Michitaka (80256510)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. SAITO Tsuyoshi (80609933)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. HAGA Sanae (60706505)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. USUI Takeo (60281648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. KAKEYA Hideaki (00270596)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. SEKIYAMA Yasuyo (60342804)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. MACHIDA Kiyotaka (30332266)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. HAMAMOTO Ryuji (80321800)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. FUJITA Naonobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. RYOUHEI Katayama

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 梅沢一夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 31 results
26. 千田憲孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Simizu Siro 清水 史郎

清水 史郎 シミズ シロウ

SIMIZU Siro 清水 史郎

Research Projects

Research Products

Co-Researchers

Role of C-mannosylation in zebrafish and development of inhibitors for C-mannosylationPrincipal Investigator

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Identification of novel enzymes for C-mannosylation and analysis of its substrate proteinsPrincipal Investigator

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Development of novel drug for bone-related diseases using Pirin inhibitorsPrincipal Investigator

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Bio-imaging of peritoneal metastasis and molecular design of inhibitors

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Administration of the group grant "Intracellular logistics: interdisciplinary approaches to pathophysiology of membrane traffic"

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Analysis of intracellular logistics by chemical biologyPrincipal Investigator

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低分子マイクロアレイを用いた蛋白質機能モジュレーターの探索と創成

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天然由来低分子マイクロアレイを発端とした蛋白質機能モジュレーターの探索と創成

Principal Investigator

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Analyses of glycosylation-regulated tumor metastasis by chemical biology approachPrincipal Investigator

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Drug discovery research based on the molecular mechanisms of tumor growth and metastasis

Principal Investigator

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糖鎖修飾によるタンパク質活性化調節機構の解析Principal Investigator

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ヘパラナーゼ阻害剤探索系の構築と活性化機構の解析Principal Investigator

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Research Institution

Role of Bcl-2 phosphorylation after microtubule disruptionPrincipal Investigator

Principal Investigator

Simizu Siro 清水史郎

清水史郎シミズシロウ

SIMIZU Siro 清水史郎

[Book] 化合物アレイを用いた抗がん剤探索系「がん分子標的治療研究実践マニュアル(日本がん分子標的治療学会編)」2009

[Book] がんの分子標的治療第III部 25 「浸潤と転移-1 タンパク質分解酵素と糖分解酵素」2008