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Simizu Siro  清水 史郎

ORCIDConnect your ORCID iD *help
… Alternative Names

清水 史郎  シミズ シロウ

SIMIZU Siro  清水 史郎

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Researcher Number 30312268
Other IDs
External Links
Affiliation (Current) 2025: 慶應義塾大学, 理工学部(矢上), 教授
Affiliation (based on the past Project Information) *help 2024: 慶應義塾大学, 理工学部(矢上), 教授
2018 – 2020: 慶應義塾大学, 理工学部(矢上), 教授
2012 – 2014: 慶應義塾大学, 理工学部, 准教授
2011: 慶應義塾大学, 理工学部, 専任講師
2010 – 2011: The Institute of Physical and Chemical Research, 理工学部, 講師 … More
2009: 独立行政法人理化学研究所, 化合物ライブラリー評価研究チーム, 専任研究員
2009: The Institute of Physical and Chemical Research, 化合物ライブラリー評価研究チーム, 専任研究貴
2008: The Institute of Physical and Chemical Research, 基幹研究所・長田抗生物質研究室, 専任研究員
2007 – 2008: 独立行政法人理化学研究所, 長田抗生物質研究室, 専任研究員
2007: The Institute of Physical and Chemical Research, 長田抗生物質研究室, 専任研究員
2004 – 2006: 独立行政法人理化学研究所, 長田抗生物質研究室, 研究員
2000 – 2003: 理化学研究所, 抗生物質研究室, 研究員 Less
Review Section/Research Field
Principal Investigator
Basic Section 43030:Functional biochemistry-related / Living organism molecular science / Biological Sciences / Functional biochemistry / Chemical biology / Biological Sciences
Except Principal Investigator
Science and Engineering / Chemical biology / Biological Sciences / Biological Sciences
Keywords
Principal Investigator
ヘパラナーゼ / がん細胞 / C型糖修飾 / PP2A / phoslactomycin / ERKs / apoptosis / 低分子化合物 / Pirin / ケミカルバイオロジー … More / ジスルフィド結合 / 転移・浸潤 / ヘパラン硫酸 / ゼブラフィッシュ / がん分子標的 / フィブリノーゲンC末端領域 / 細胞外分泌 / Isthmin-1 / ADAMTS4 / MFAP4 / R-spondin2 / ERK2 / 細胞周期 / リン酸化 / ミトコンドリア / Bc1-2 / Erk / Bcl-2 / 構造活性相関 / 骨転移 / 骨粗鬆症 / 骨疾患 / RANKL / 破骨細胞分化 / 破骨細胞 / 骨関連疾患 / NPDepo / 赤色蛍光タンパク質 / 公的化合物バンク施設 / 分化誘導 / メラノーマ細胞 / がん細胞遊走 / 化合物バンク / VCP / G3BP / RelB / NF-κB / PDGF / がん細胞の浸潤・転移 / 細胞内ロジスティクス / 化合物アレイ / 質量分析 / システイン化 / がん転移 / プロテオーム法 / 化学生物学 / 生体高分子 / RECK / マトリックスメタロプロテアーゼ / 転移 / 糖鎖修飾 / プロテインキナーゼC / DNAメチル化 / mRNA / RT-PCR法 / WI-38細胞 / HepG2細胞 … More
Except Principal Investigator
isoavenaciolide / phoslactomycin / 蛋白質機能モジュレーター / リガンドスクリーニング / 低分子アフィニティービーズ / 低分子マイクロアレイ / アポトーシス / ケミカルバイオロジー / dephosphorylation / apoptosis / biosynthesis / inhibitor / phosphatase / テトロン酸 / 分子設計 / RK-682 / 活性中心 / Michael付加 / VHR / 4-isoavenaciolide / リン酸化 / Bcl-2 / 脱リン酸化 / 生合成系 / 阻害剤 / ホスファターゼ / 光プローブ / 標的タンパク質 / 探索プローブ / NF-κB / 卵巣癌 / メラノーマ / アノイキス / 転移 / 卵巣がん / pyrapaxilline / Exo-ene EQ / migracin / DTCM-glutarimide / DHMEQ / NF-kappa B / 遊走 / 浸潤 / 腹腔内転移 / バイオイメージング / 分子デザイン / 高次生体システム / 情報科学 / 疾患 / アウトリーチ / 融合研究 / 病態の理解 / 細胞内ロジスティクス / 画像解析 / オルガネラ / 社会還元 / 成果報告 / 情報発信 / 分子細胞生物学 / 情報科学・工学 / 細胞内輸送 / メンブレントラフィック / 金属依存性マトリックス分解酵素 / 破骨細胞 / がん細胞 / V-ATPase / イエジマライド / 骨転移 / リベロマイシンA / ビオチン / VEGF / 血管内皮細胞 / Epoxyquinol B / 放線菌 / GLO1 / メチルゲルフィリン / 2D-DIGE / リベロマイシン / p38 / 生合成遺伝子 / プロテオミクス / フミトレモルジン / プロテオーム / 天然化合物 / 血管新生 / 癌転移 Less
  • Research Projects

    (15 results)
  • Research Products

    (257 results)
  • Co-Researchers

    (26 People)
  •  Role of C-mannosylation in zebrafish and development of inhibitors for C-mannosylationPrincipal Investigator

    • Principal Investigator
      清水 史郎
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 43030:Functional biochemistry-related
    • Research Institution
      Keio University
  •  Identification of novel enzymes for C-mannosylation and analysis of its substrate proteinsPrincipal Investigator

    • Principal Investigator
      Simizu Siro
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 43030:Functional biochemistry-related
    • Research Institution
      Keio University
  •  Development of novel drug for bone-related diseases using Pirin inhibitorsPrincipal Investigator

    • Principal Investigator
      SIMIZU Siro
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Chemical biology
    • Research Institution
      Keio University
  •  Bio-imaging of peritoneal metastasis and molecular design of inhibitors

    • Principal Investigator
      UMEZAWA Kazuo
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Chemical biology
    • Research Institution
      Aichi Medical University
      Keio University
  •  Administration of the group grant "Intracellular logistics: interdisciplinary approaches to pathophysiology of membrane traffic"

    • Principal Investigator
      YOSHIMORI Tamotsu
    • Project Period (FY)
      2008 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University
  •  Analysis of intracellular logistics by chemical biologyPrincipal Investigator

    • Principal Investigator
      SIMIZU Siro
    • Project Period (FY)
      2008 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Keio University
      The Institute of Physical and Chemical Research
  •  低分子マイクロアレイを用いた蛋白質機能モジュレーターの探索と創成

    • Principal Investigator
      叶 直樹
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Science and Engineering
    • Research Institution
      Tohoku University
  •  天然由来低分子マイクロアレイを発端とした蛋白質機能モジュレーターの探索と創成

    • Principal Investigator
      叶 直樹
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Science and Engineering
    • Research Institution
      Tohoku University
  •  Analyses of glycosylation-regulated tumor metastasis by chemical biology approachPrincipal Investigator

    • Principal Investigator
      SHIMIZU Siro
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      Living organism molecular science
    • Research Institution
      The Institute of Physical and Chemical Research
  •  Drug discovery research based on the molecular mechanisms of tumor growth and metastasis

    • Principal Investigator
      OSADA Hiroyuki
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The Institute of Physical and Chemical Research
  •  糖鎖修飾によるタンパク質活性化調節機構の解析Principal Investigator

    • Principal Investigator
      清水 史郎
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Living organism molecular science
    • Research Institution
      The Institute of Physical and Chemical Research
  •  ヘパラナーゼ阻害剤探索系の構築と活性化機構の解析Principal Investigator

    • Principal Investigator
      清水 史郎
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      The Institute of Physical and Chemical Research
  •  Role of Bcl-2 phosphorylation after microtubule disruptionPrincipal Investigator

    • Principal Investigator
      SIMIZU Siro
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional biochemistry
    • Research Institution
      RIKEN
  •  ヘパラナーゼ阻害剤探索系の構築と活性化機構の解析Principal Investigator

    • Principal Investigator
      清水 史郎
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      The Institute of Physical and Chemical Research
  •  Chemical biology study on protein phosphatases and their specific inhibitors.

    • Principal Investigator
      OSADA Hiroyuki
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Science and Engineering
    • Research Institution
      RIKEN

All 2021 2020 2019 2018 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book

  • [Book] がん分子標的治療研究ハンドブック2009

    • Author(s)
      清水史郎、宮崎功、本田香織、近藤恭光、長田裕之
    • Publisher
      金芳堂
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Book] 化合物アレイを用いた抗がん剤探索系「がん分子標的治療研究 実践マニュアル(日本がん分子標的治療学会編)」2009

    • Author(s)
      清水史郎, 他
    • Total Pages
      340
    • Publisher
      金芳堂
    • Data Source
      KAKENHI-PROJECT-17016079
  • [Book] 化合物アレイを用いた抗がん剤探索系がん分子標的治療研究実践マニュアル2009

    • Author(s)
      清水史郎、宮崎功、本田香織、近藤恭光、長田裕之、金芳堂
    • Publisher
      日本がん分子標的治療学会
    • Data Source
      KAKENHI-PROJECT-17016079
  • [Book] 浸潤と転移-1タンパク質分解酵素と糖分解酵素「がんの分子標的治療(鶴尾隆編)」2008

    • Author(s)
      清水史郎、長田裕之
    • Publisher
      南山堂
    • Data Source
      KAKENHI-PROJECT-17016079
  • [Book] がんの分子標的治療 第III部 25 「浸潤と転移-1 タンパク質分解酵素と糖分解酵素」2008

    • Author(s)
      清水 史郎, 他
    • Total Pages
      441
    • Publisher
      南山堂
    • Data Source
      KAKENHI-PROJECT-17016079
  • [Book] がんの分子標的治療2008

    • Author(s)
      清水史郎、長田裕之
    • Publisher
      南山堂
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Book] 「低分子アレイ」マイクロアレイ・バイオチップの最新技術2007

    • Author(s)
      清水史郎, 宮崎功, 近藤恭光, 叶直樹, 長田裕之
    • Total Pages
      305
    • Publisher
      シーエムシー出版
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Book] マイクロアレイ・バイオチップの最新技術2007

    • Author(s)
      清水史郎
    • Total Pages
      305
    • Publisher
      シーエムシー出版
    • Data Source
      KAKENHI-PROJECT-19021005
  • [Book] マイクロアレイ・バイオチップの最新技術2007

    • Author(s)
      清水史郎、他
    • Total Pages
      305
    • Publisher
      シーエムシー出版
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Book] マイクロアレイ・バイオチップの最新技術2007

    • Author(s)
      清水史郎
    • Total Pages
      305
    • Publisher
      シーエムシー出版
    • Data Source
      KAKENHI-PROJECT-18038044
  • [Journal Article] Requirement for C-mannosylation to be secreted and activated a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4)2021

    • Author(s)
      Miura K、Suzuki T、Sun H、Takada H、Ishizawa Y、Mizuta H、Dohmae N、Simizu S
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - General Subjects

      Volume: 1865 Issue: 3 Pages: 129833-129833

    • DOI

      10.1016/j.bbagen.2020.129833

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Journal Article] Identification of madangamine A as a novel lysosomotropic agent to inhibit autophagy2021

    • Author(s)
      Miura Kazuki、Kawano Sayaka、Suto Takahiro、Sato Takaaki、Chida Noritaka、Simizu Siro
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 34 Pages: 116041-116041

    • DOI

      10.1016/j.bmc.2021.116041

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K22189, KAKENHI-PROJECT-18H01984, KAKENHI-PROJECT-18K06137
  • [Journal Article] Seven‐Step Synthesis of All‐Nitrogenated Sugar Derivatives Using Sequential Overman Rearrangements2021

    • Author(s)
      Okuyama Yuya、Kidena Mayu、Kato Erina、Kawano Sayaka、Ishii Koki、Maie Kenta、Miura Kazuki、Simizu Siro、Sato Takaaki、Chida Noritaka
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 60 Issue: 10 Pages: 5193-5198

    • DOI

      10.1002/anie.202015141

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K22189, KAKENHI-PROJECT-18H01984, KAKENHI-PROJECT-19J12788, KAKENHI-PROJECT-18K05127, KAKENHI-PROJECT-18K06137
  • [Journal Article] Regulation of N-glycosylation and secretion of Isthmin-1 by its C-mannosylation2021

    • Author(s)
      Yoshimoto S、Katayama K、Suzuki T、Dohmae N、Simizu S
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - General Subjects

      Volume: 1865 Issue: 3 Pages: 129840-129840

    • DOI

      10.1016/j.bbagen.2020.129840

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Journal Article] Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer2021

    • Author(s)
      Mizuta Hayato、Okada Koutaroh、Araki Mitsugu、Adachi Jun、Takemoto Ai、Kutkowska Justyna、Maruyama Kohei、Friboulet Luc、Katayama Kazuhiro、Ma Biao、Sasakura Yoko、Sagae Yukari、Kukimoto-Niino Mutsuko、Shirouzu Mikako、Takagi Satoshi、Simizu Siro、Nishio Makoto、Okuno Yasushi、Fujita Naoya、Katayama Ryohei, et al
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 1261-1261

    • DOI

      10.1038/s41467-021-21396-w

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K21554, KAKENHI-PLANNED-17H06327, KAKENHI-PROJECT-19H03524, KAKENHI-PROJECT-18K06137, KAKENHI-PROJECT-19K22572, KAKENHI-PROJECT-18K06594, KAKENHI-ORGANIZER-17H06324
  • [Journal Article] Identification of vibsanin A analog as a novel HSP90 inhibitor2020

    • Author(s)
      Miura Kazuki、Matsuki Wataru、Ogura Akihiro、Takao Ken-ichi、Simizu Siro
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 28 Issue: 2 Pages: 115253-115253

    • DOI

      10.1016/j.bmc.2019.115253

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06137, KAKENHI-PROJECT-19K15571
  • [Journal Article] The fibrinogen C-terminal domain is seldom C-mannosylated but its C-mannosylation is important for the secretion of microfibril-associated glycoprotein 42020

    • Author(s)
      Osada Y、Suzuki T、Mizuta H、Mori K、Miura K、Dohmae N、Simizu S
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - General Subjects

      Volume: 1864 Issue: 9 Pages: 129637-129637

    • DOI

      10.1016/j.bbagen.2020.129637

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Journal Article] Total Synthesis of Natural Products Using Intramolecular Nozaki?Hiyama?Takai?Kishi Reactions2020

    • Author(s)
      Takao Ken-ichi、Ogura Akihiro、Yoshida Keisuke、Simizu Siro
    • Journal Title

      Synlett

      Volume: 31 Issue: 05 Pages: 421-433

    • DOI

      10.1055/s-0039-1691580

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06137, KAKENHI-PROJECT-19K15571
  • [Journal Article] Cell-dependent regulation of vasculogenic mimicry by carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1)2020

    • Author(s)
      Hayashi Soichiro、Osada Yoshiyuki、Miura Kazuki、Simizu Siro
    • Journal Title

      Biochemistry and Biophysics Reports

      Volume: 21 Pages: 100734-100734

    • DOI

      10.1016/j.bbrep.2020.100734

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Journal Article] Identification of topoisomerases as molecular targets of cytosporolide C and its analog2019

    • Author(s)
      Otake Keisuke、Yamada Kana、Miura Kazuki、Sasazawa Yukiko、Miyazaki So、Niwa Yuki、Ogura Akihiro、Takao Ken-ichi、Simizu Siro
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 27 Issue: 15 Pages: 3334-3338

    • DOI

      10.1016/j.bmc.2019.06.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06137, KAKENHI-PROJECT-19K15571, KAKENHI-PROJECT-18K15464, KAKENHI-PROJECT-16H06276
  • [Journal Article] Identification and characterization of collagen-like glycosylation and hydroxylation of CCN12019

    • Author(s)
      Ishizawa Yudai、Niwa Yuki、Suzuki Takehiro、Kawahara Ryota、Dohmae Naoshi、Simizu Siro
    • Journal Title

      Glycobiology

      Volume: 29 Issue: 10 Pages: 696-704

    • DOI

      10.1093/glycob/cwz052

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Journal Article] C-mannosylation of R-spondin2 activates Wnt/β-catenin signaling and migration activity in human tumor cells.2019

    • Author(s)
      Mizuta, H., Kuga, K., Suzuki, T., Niwa, Y., Dohmae, N. & Simizu, S.
    • Journal Title

      International Journal of Oncology

      Volume: - Pages: 2127-2138

    • DOI

      10.3892/ijo.2019.4767

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06137, KAKENHI-PROJECT-17K15094
  • [Journal Article] Unified total synthesis of madangamine alkaloids.2019

    • Author(s)
      Suto, T., Yanagita, Y., Nagashima, Y., Takikawa, S., Kurosu, Y., Matsuo, N., Miura, K., Simizu, S., Sato, T. & Chida, N.
    • Journal Title

      Bulletin of the Chemical Society of Japan

      Volume: 92 Pages: 545-571

    • NAID

      130007611672

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Journal Article] C-mannosylation; previous studies and future research perspectives.2018

    • Author(s)
      Niwa, Y. & Simizu, S.
    • Journal Title

      Trends in Glycoscience and Glycotechnology

      Volume: 30

    • NAID

      130007521336

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Journal Article] Integrin β1 is an essential factor in vasculogenic mimicry of human cancer cells.2018

    • Author(s)
      Kawahara, R., Niwa, Y. & Simizu, S.
    • Journal Title

      Cancer Science

      Volume: 109 Issue: 8 Pages: 2490-2496

    • DOI

      10.1111/cas.13693

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06137, KAKENHI-PROJECT-17K15094
  • [Journal Article] Activation of apoptosis by caspase-3-dependent specific RelB cleavage in anticancer agent-treated cancer cells: involvement of positive feedback mechanism2015

    • Author(s)
      Kuboki M, Ito A, Simizu S, Umezawa K.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 456 Issue: 3 Pages: 810-814

    • DOI

      10.1016/j.bbrc.2014.12.024

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Journal Article] Inhibition of MMP-2-Mediated Mast Cell Invasion by NF-κB Inhibitor DHMEQ in Mast Cells2015

    • Author(s)
      Noma N, Asagiri M, Takeiri M, Ohmae S, Takemoto K, Iwaisako K, Minato N, Maeda-Yamamoto M, Simizu S, Umezawa K.
    • Journal Title

      Int. Arch. Allergy Immunol.

      Volume: 166 Pages: 84-90

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Journal Article] N-Glycosylation of extracellular matrix protein 1 (ECM1) regulates its secretion, which is unrelated to lipoid proteinosis2015

    • Author(s)
      Uematsu S, Goto Y, Suzuki T, Sasazawa Y, Dohmae N, Simizu S.
    • Journal Title

      FEBS Open Bio

      Volume: 4 Issue: 1 Pages: 879-885

    • DOI

      10.1016/j.fob.2014.10.004

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24310167, KAKENHI-PROJECT-26750373
  • [Journal Article] Isolation of a novel paxilline analog pyrapaxilline from fungus that inhibits LPS-induced NO production2015

    • Author(s)
      Matsui C, Ikeda Y, Iinuma H, Kushida N, Kunisada T, Simizu S, Umezawa K.
    • Journal Title

      J. Antibiot.

      Volume: 67 Issue: 11 Pages: 787-790

    • DOI

      10.1038/ja.2014.63

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Journal Article] Pirin regulates the epithelial to mesenchymal transition independently of Bcl3-Slug signaling.2015

    • Author(s)
      Komai, K., Niwa, Y., Sasazawa, Y. & Simizu, S.
    • Journal Title

      FEBS Lett.

      Volume: 589 Issue: 6 Pages: 738-743

    • DOI

      10.1016/j.febslet.2015.01.040

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-13J04256, KAKENHI-PROJECT-24310167, KAKENHI-PROJECT-26750373
  • [Journal Article] Conophylline Protects Cells in Cellular Models of Neurodegenerative Diseases by Inducing Mammalian Target of Rapamycin (mTOR)-independent Autophagy2015

    • Author(s)
      Sasazawa Y, Sato N, Umezawa K, Simizu S.
    • Journal Title

      J. Biol. Chem.

      Volume: 290 Issue: 10 Pages: 6168-6178

    • DOI

      10.1074/jbc.m114.606293

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24310167, KAKENHI-PROJECT-26750373
  • [Journal Article] Isolation of a novel paxilline analog pyrapaxilline from fungus that inhibits LPS-induced NO production2014

    • Author(s)
      C. Matsui, Y. Ikeda, H. Iinuma, N. Kushida, T. Kunisada, S. Simizu and K. Umezawa
    • Journal Title

      J. Antibiotics

      Volume: 未定

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] C-mannosylation of human hyaluronidase 1: Possible roles for secretion and enzymatic activity.2014

    • Author(s)
      Goto, Y., Niwa, Y., Suzuki, T., Dohmae, N., Umezawa, K. & Simizu, S.
    • Journal Title

      Int. J. Oncol.

      Volume: 45 Issue: 1 Pages: 344-350

    • DOI

      10.3892/ijo.2014.2438

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-13J04256, KAKENHI-PROJECT-24310167
  • [Journal Article] Involvement of conserved tryptophan residues for secretion of TIMP-22014

    • Author(s)
      Ukaji, T., Sasazawa, Y., Umezawa, K. & Simizu, S.
    • Journal Title

      Oncology Letters

      Volume: 7 Pages: 631-634

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Journal Article] N-glycosylation is required for secretion and enzymatic activity of human hyaluronidase1.2014

    • Author(s)
      Goto, Y., Niwa, Y., Suzuki, T., Uematsu, S., Dohmae, N. & Simizu, S.
    • Journal Title

      FEBS Open Bio

      Volume: 4 Issue: 1 Pages: 554-559

    • DOI

      10.1016/j.fob.2014.06.001

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-13J04256, KAKENHI-PROJECT-24310167
  • [Journal Article] Inhibition of NO-induced β-cell death by novel NF-κB inhibitor (-)-DHMEQ via activation of Nrf2-ARE pathway2013

    • Author(s)
      A. Ogasawara, S. Simizu, A. Ito, T. Kawai, Y. Saisho, I. Takei and K. Umezawa
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 433 Pages: 181-187

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Migracins A and B, new inhibitors of cancer cell migration, produced by Streptomyces sp2013

    • Author(s)
      Y. Arai, H. Iinuma, Y. Ikeda, M. Igarashi, K. Hatano, N. Kinoshita, T. Ukaji, S. Simizu and K. Umezawa
    • Journal Title

      J. Antibiot.

      Volume: 66

    • NAID

      10031168683

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Migracins A and B, new inhibitors of cancer cell migration, produced by Streptomyces sp2013

    • Author(s)
      Arai, Y., Iinuma, H., Ikeda, Y., Igarashi, M., Hatano, M., Kinoshita, N., Ukaji, T., Simizu, S. & Umezawa, K
    • Journal Title

      The Journal of Antibiotics

      Volume: (掲載決定) Issue: 4 Pages: 225-230

    • DOI

      10.1038/ja.2012.112

    • NAID

      10031168683

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113008, KAKENHI-PROJECT-24310167
  • [Journal Article] Migracins A and B, new inhibitors of cancer cell migration, produced by Streptomyces sp2013

    • Author(s)
      Y. Arai, H. Iinuma, Y. Ikeda, M. Igarashi, K. Hatano, N. Kinoshita, T. Ukaji, S. Simizu and K. Umezawa
    • Journal Title

      J. Antibiot

      Volume: 66 Pages: 225-230

    • NAID

      10031168683

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Inhibition of NO-induced β-cell death by novel NF-κB inhibitor (-)-DHMEQ via activation of Nrf2-ARE pathway2013

    • Author(s)
      Ogasawara, A., Simizu, S., Ito, A., Kawai, T., Saisho, Y., Takei, I. & Umezawa, K
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: (掲載決定) Issue: 2 Pages: 181-187

    • DOI

      10.1016/j.bbrc.2013.02.062

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113008, KAKENHI-PROJECT-24310167
  • [Journal Article] Determination of topological structure of ARL6ip1 in cells: identification of the essential binding region of ARL6ip1 for conophylline2013

    • Author(s)
      Kuroda, M., Funasaki, S., Saitoh, T., Sasazawa, Y., Nishiyama, S., Umezawa, K. & Simizu, S.
    • Journal Title

      FEBS Letters

      Volume: 587 Issue: 22 Pages: 3656-3660

    • DOI

      10.1016/j.febslet.2013.09.017

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24310167, KAKENHI-PROJECT-24810025
  • [Journal Article] Practical molecular targets for suppression of metastasis2013

    • Author(s)
      Simizu, S. & Niwa, Y.
    • Journal Title

      Forum on Immunopathological Diseases and Therapeutics

      Volume: 4 Pages: 43-51

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Journal Article] Boronic acid inhibitors of acyl protein thioesterase 1 and 22013

    • Author(s)
      Zimmermann, T.J., Burger, M., Tashiro, E., Kondoh, Y., Martinez, N.E., Gormer, K., Rosin-steiner, S., Shimizu, T. Ozaki, S., Mikoshiba, K., Watanabe, N., Hall, D., Vetter, I.R., Osada, H., Hedberg, C., & Waldmann, H
    • Journal Title

      ChemBioChem

      Volume: 14 Issue: 1 Pages: 115-122

    • DOI

      10.1002/cbic.201200571

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113008, KAKENHI-PROJECT-20220007, KAKENHI-PROJECT-23510287, KAKENHI-PROJECT-24510320
  • [Journal Article] Structure-activity relationship Of 9-methylstreptimidone that induces selective apoptosis in adult T-cell leukemia cells2012

    • Author(s)
      M.Takeiri, S.Simizu, K.Umezawa, et al
    • Journal Title

      Oncology Res.

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Involvement of DNA binding domain in the cellular stability and importin affinity of NF-κB component RelB2012

    • Author(s)
      Takeiri, M., Horie, K., Takahashi, D., Watanabe, M., Horie, R., Simizu, S. & Umezawa, K
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 10 Issue: 15 Pages: 3053-3059

    • DOI

      10.1039/c2ob07104e

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113008, KAKENHI-PROJECT-23590432, KAKENHI-PROJECT-23590433
  • [Journal Article] Determination of cathepsin V activity and intracellular trafficking by N-glycosylation2012

    • Author(s)
      Niwa, Y., Suzuki, T., Dohmae, N., Umezawa, K. & Simizu, S
    • Journal Title

      FEBS Letters

      Volume: 586 Issue: 20 Pages: 3601-3607

    • DOI

      10.1016/j.febslet.2012.08.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113008, KAKENHI-PROJECT-24310167
  • [Journal Article] Suppression of cellular invasion by glybenclamide through inhibited secretion of platelet-derived growth factor in ovarian clear cell carcinoma ES-2 cells2012

    • Author(s)
      T. Yasukagawa, Y. Niwa, S. Simizu and K. Umezawa
    • Journal Title

      FEBS Lett.

      Volume: 586

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] ErbB receptor tyrosine kinase/NF-κB signaling controls mammosphere formation in human breast cancer2012

    • Author(s)
      K. Hinohara, S. Kobayashi, S. Simizu, K. Tada, E. Tsuji, K. Nishioka, K. Umezawa, M. Mori, H. Kanauchi, T. Ogawa, J. Inoue, A. T and N. Gotoh
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 109 Pages: 6584-6589

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Protein disulfide isomerase-mediated disulfide bonds regulate the gelatinolytic activity and secretion of matrix metalloproteinase-92012

    • Author(s)
      Khan, M. G. M., Simizu, S., Suzuki, T., Masuda, A., Muroi, M., Kawatani, M., Dohmae, N. & Osada, H
    • Journal Title

      Experimental Cell Research

      Volume: 318 Issue: 8 Pages: 904-914

    • DOI

      10.1016/j.yexcr.2012.02.021

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113008, KAKENHI-PROJECT-22681034
  • [Journal Article] Involvement of NF-κB-mediated expression of galectin-3-binding protein in tumor necrosis factor-α-induced breast cancer cell adhesion2012

    • Author(s)
      N. Noma, S. Simizu, Y. Kambayashi, Y. Kabe, M. Suematsu, and K. Umezawa
    • Journal Title

      Oncology Reports

      Volume: 27 Pages: 2080-2084

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Suppression of cellular invasion by glybenclamide through inhibited secretion of platelet-derived growth factor in ovarian clear cell carcinoma ES-2 cells2012

    • Author(s)
      Yasukagawa, T., Niwa, Y., Simizu, S. & Umezawa, K
    • Journal Title

      FEBS Letters

      Volume: 586 Issue: 10 Pages: 1504-1509

    • DOI

      10.1016/j.febslet.2012.04.007

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113008, KAKENHI-PROJECT-24310167
  • [Journal Article] Involvement of DNA binding domain in the cellular stability and importin affinity of NF-κB component RelB2012

    • Author(s)
      M. Takeiri, K. Horie, D. Takahashi, M. Watanabe, R. Horie, S. Simizu and K. Umezawa
    • Journal Title

      Org. Biomol. Chem.

      Volume: 10 Pages: 3053-3059

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Inhibition of lysenin-induced hemolysis by all-E-lutein derived from the plant Dalbergia latifolia2012

    • Author(s)
      Niwa, Y., Matsui, C., Sukumwang, N., Iinuma, H., Ikeda, Y., Koyano, T., Kovitayakorn, T., Simizu, S. & Umezawa, K
    • Journal Title

      Planta Medica

      Volume: 78 Issue: 10 Pages: 957-961

    • DOI

      10.1055/s-0031-1298538

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113008, KAKENHI-PROJECT-24310167
  • [Journal Article] Suppression of cellular invasion by glybenclamide through inhibited secretion of platelet-derived growth factor in ovarian clear cell carcinoma ES-2 cells2012

    • Author(s)
      T. Yasukagawa, Y. Niwa, S. Simizu and K. Umezawa
    • Journal Title

      FEBS Lett

      Volume: 586 Pages: 1504-1509

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Structure-activity relationship of 9-methylstreptimidone that induces selective apoptosis in adult T-cell leukemia cells2012

    • Author(s)
      M. Takeiri, E. Ota, S. Nishiyama, H. Kiyota, S. Simizu and K. Umezawa
    • Journal Title

      Oncology Res.

      Volume: 20 Pages: 7-14

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Involvement of NF-κB-mediated expression of galectin-3-binding protein in tumor necrosis factor-α-induced brest cancer cell adhesion2012

    • Author(s)
      Noma, N., Simizu, S., Kambayashi, Y., Kabe, Y., Suematsu, M. & Umezawa, K
    • Journal Title

      Oncology Reports

      Volume: 27 Pages: 2080-2084

    • DOI

      10.3892/or.2012.1733

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113008, KAKENHI-PROJECT-23310163
  • [Journal Article] Involvement of DNA binding domain in the cellular stability and importin affinity of NF-κB component RelB2012

    • Author(s)
      M. Takeiri, K. Horie, D. Takahashi, M. Watanabe, R. Horie, S. Simizu and K. Umezawa
    • Journal Title

      Org. Biomol. Chem

      Volume: 10 Pages: 3053-3059

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Development of a vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structure2011

    • Author(s)
      Hirai, G., Tsuchiya, A., Koyama, Y., Otani, Y., Oonuma, K., Dodo, K., Simizu, S., Osada, H. & Sodeoka, M
    • Journal Title

      ChemMedChem

      Volume: 6 Issue: 4 Pages: 617-622

    • DOI

      10.1002/cmdc.201100107

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113008, KAKENHI-PROJECT-23790006
  • [Journal Article] Discovery of a small molecule PDI inhibitor that inhibits reduction of HIV-1 envelope glycoprotein gp1202011

    • Author(s)
      Khan, M. G. M., Simizu, S., Lai, N. S., Kawatani, M., Shimizu, T. & Osada, H
    • Journal Title

      ACS Chemical Biology

      Volume: 6 Issue: 3 Pages: 245-251

    • DOI

      10.1021/cb100387r

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Journal Article] Inhibition of autophagy potentiates the antitumor effect of the multikinase inhibitor sorafenib in hepatocellular carcinoma2011

    • Author(s)
      Shimizu S, Takehara T, Hikita H, Kodama T, Tsunematsu H, Miyagi T, Hosui A, Ishida H, Tatsumi T, Kanto T, Hiramatsu N, Fujita N, Yoshimori T, Hayashi N
    • Journal Title

      Int.J.Cancer

      Volume: 131 Issue: 3 Pages: 548-57

    • DOI

      10.1002/ijc.26374

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-22020023, KAKENHI-PROJECT-22590729, KAKENHI-PROJECT-22770194, KAKENHI-PROJECT-23247034, KAKENHI-PROJECT-23390197, KAKENHI-PROJECT-23657129, KAKENHI-ORGANIZER-20113001, KAKENHI-PLANNED-20113002
  • [Journal Article] 化合物アレイを起点としたケミカルバイオロジー化合物アレイの基盤技術開発から機能未知タンパク質の機能解析まで2011

    • Author(s)
      叶直樹、清水史郎
    • Journal Title

      化学と工業

      Volume: 64 Pages: 37-39

    • NAID

      10027655880

    • Data Source
      KAKENHI-PLANNED-20113008
  • [Journal Article] Discovery of a small molecule PDI inhibitor that inhibits reduction of HIV-1 envelope glycoprotein gp120.2011

    • Author(s)
      Khan, M.G.M., Simizu, S., Lai, N.S., Kawatani, M., Shimizu, T., Osada, H.
    • Journal Title

      ACS Chem.Biol. 6

      Pages: 245-251

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Journal Article] A small-molecule inhibitor shows that pirin regulatesmigration of melanoma cells2010

    • Author(s)
      Miyazaki I, Simizu S, Okumura H, Takagi S, Osada H
    • Journal Title

      Nat Chem Biol 6

      Pages: 667-673

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-20113001
  • [Journal Article] Cleavable linker for photo-cross-linked small-molecule affinity matrix.2010

    • Author(s)
      Kanoh, N. (8名中1番目), Simizu, S. (8名中6番目), Osada, H. (8名中7番目)
    • Journal Title

      Bioconjugate Chem. 21

      Pages: 182-186

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079
  • [Journal Article] A small-molecule inhibitor shows that pirin regulates migration of melanoma cells.2010

    • Author(s)
      Miyazaki, I., Simizu, S., Okumura, H., Takagi, S., Osada, H.
    • Journal Title

      Nature Chem.Biol. 6

      Pages: 667-673

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Journal Article] Involvement of autocrine CXCL12/CXCR4 system in the regulation of ovarian carcinoma cell invasion2010

    • Author(s)
      Miyanishi, N., Suzuki, Y., Simizu, S., Kuwabara, Y., Banno, K. & Umezawa, K
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 403 Issue: 1 Pages: 154-159

    • DOI

      10.1016/j.bbrc.2010.11.007

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Journal Article] Cleavable linker for photo-cross-linked small-molecule affinity matrix2010

    • Author(s)
      Kanoh, N., Takayama, H., Honda, K., Moriya, T., Teruya, T., Simizu, S., Osada, H. & Iwabuchi, Y
    • Journal Title

      Bioconjugate Chemistry

      Volume: 21 Issue: 1 Pages: 182-186

    • DOI

      10.1021/bc900316q

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Journal Article] A small-molecule inhibitor shows that pirin regulates migration of melanoma cells2010

    • Author(s)
      Miyazaki, I., Simizu, S., Okumura, H., Takagi, S. & Osada, H
    • Journal Title

      Nature Chemical Biology

      Volume: 6 Issue: 9 Pages: 667-673

    • DOI

      10.1038/nchembio.423

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Journal Article] Identification of a novel Vpr-binding compound that inhibits HIV-1 multiplication in macrophages by chemical array2010

    • Author(s)
      Hagiwara, K., Murakami, T., Xue, G., Shimizu, Y., Takeda, E., Hashimoto, Y., Honda, K., Kondoh, Y., Osada, H., Tsunetsugu-Yokota, Y. & Aida, Y
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 403 Issue: 1 Pages: 40-45

    • DOI

      10.1016/j.bbrc.2010.10.107

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Journal Article] Polo-like kinase 1 phosphorylates and regulates Bcl-xL during pironetin-induced apoptosis.2009

    • Author(s)
      Simizu, S. (7名中2番目), Muroi, M. (7名中3番目), Osada, H. (7名中7番目)
    • Journal Title

      Oncogene 28

      Pages: 107-116

    • NAID

      120006385868

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079
  • [Journal Article] Structure-affinity relationship study of bleomycins and Shble protein by use of a chemical array2009

    • Author(s)
      Miyazaki, I., Okumura, H., Simizu, S., Takahashi, Y., Kanoh, N., Muraoka, Y., Nonomura, Y. & Osada, H
    • Journal Title

      ChemBioChem

      Volume: 10 Issue: 5 Pages: 845-852

    • DOI

      10.1002/cbic.200800728

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Journal Article] Deamino-hydroxy-phoslactomycin B, a biosynthetic precursor of phoslactomycin, induces myeloid differentiation in HL-60 cells2009

    • Author(s)
      Simizu, S., et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 383

      Pages: 406-410

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079
  • [Journal Article] RECK negatively regulates matrix metalloproteinase-9 transcription2009

    • Author(s)
      Takagi, S., Simizu, S., Osada, H.
    • Journal Title

      Cancer Res. 69

      Pages: 1502-1508

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Journal Article] Structure-affinity relationship study of bleomycins and Shble protein by use of a chemical array.2009

    • Author(s)
      Miyazaki, I., Okumura, H., Simizu, S., Takahashi, Y., Kanoh, N., Muraoka, Y., Nonomura, Y., Osada, H.
    • Journal Title

      ChemBioChem 10

      Pages: 845-852

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Journal Article] A cell-based screening to detect inhibitors of BRAF signaling pathway2009

    • Author(s)
      Asami, Y., Mori, M., Koshino, H., Sekiyama, Y., Teruya, T., Simizu, S., Usui, T., Osada, H.
    • Journal Title

      J. Antibiot. 62

      Pages: 105-107

    • NAID

      10030634719

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Journal Article] RECK negatively regulates matrix metalloproteinase-9 transcription.2009

    • Author(s)
      Simizu, S. (3名中2番目), Osada, H. (3名中3番目)
    • Journal Title

      Cancer Res. 69

      Pages: 1502-1508

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079
  • [Journal Article] RECK negatively regulates matrix metalloproteinase-9 transcription2009

    • Author(s)
      Takagi, S., Simizu, S. & Osada, H
    • Journal Title

      Cancer Research

      Volume: 69 Issue: 4 Pages: 1502-1508

    • DOI

      10.1158/0008-5472.can-08-2635

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Journal Article] On-chip fragment-based approach for discovery of high-affinity bivalent inhibitors2009

    • Author(s)
      Miyazaki, I., Simizu, S., Ishida, K. & Osada, H
    • Journal Title

      ChemBioChem

      Volume: 10 Issue: 5 Pages: 838-843

    • DOI

      10.1002/cbic.200800704

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Journal Article] Structure-affinity relationship study of bleomycins and Shble protein by use of a chemical array.2009

    • Author(s)
      Simizu, S. (8名中3番目), Kanoh, N. (8名中5番目), Osada, H. (8名中8番目)
    • Journal Title

      Chembiochem 10

      Pages: 845-852

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079
  • [Journal Article] Structure-affinity relationship study of bleomycins and Shble protein by use of a chemical array2009

    • Author(s)
      Miyazaki, I., Okumura, H., Simizu, S., Takahashi, Y., Kanoh, N., Muraoka, Y., Nonomura, Y., Osada, H.
    • Journal Title

      Chembiochem 10

      Pages: 845-852

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Journal Article] Deamino-hydroxy-phoslactomycin B, a biosynthetic precursor of phoslactomycin, induces myeloid differentiation in HL-60 cells.2009

    • Author(s)
      Simizu, S. (8名中1番目), Osada, H. (8名中8番目)
    • Journal Title

      Biochem. Biophys. Res. Commun. 383

      Pages: 406-410

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079
  • [Journal Article] Deamino-hydroxy-phoslactomycin B, a biosynthetic precursor of phoslactomycin, induces myeloid differentiation in HL-60 cells2009

    • Author(s)
      Simizu, S., Teruya, T., Nogawa, T., Aono, H., Ueki, M., Uramoto, M., Kobayashi, Y. & Osada, H
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 383 Issue: 4 Pages: 406-410

    • DOI

      10.1016/j.bbrc.2009.04.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Journal Article] The Stent-Eluting Drugs Sirolimus and Paclitaxel Suppress Healing of the Endothelium by Induction of Autophagy.2009

    • Author(s)
      Hayashi Sl, Yamamoto A, You F, Yamashita K, Ikegame Y, Tawada M, Yoshimori T, Shimizu S, Nakashima S.
    • Journal Title

      Am J Pathol. 175

      Pages: 2226-2234

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-20113001
  • [Journal Article] Polo-like kinase 1 phosphorylates and regulates Bcl-xL during pironetin-induced apoptosis2009

    • Author(s)
      Tamura, Y., Simizu, S., Muroi, M., Takagi, S., Kawatani, M., Watanabe, N., Osada, H.
    • Journal Title

      Oncogene 28

      Pages: 107-116

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Journal Article] On-chip fragment-based approach for discovery of high-affinity bivalent inhibitors.2009

    • Author(s)
      Simizu, S. (4名中2番目), Osada, H. (4名中4番目)
    • Journal Title

      Chembiochem 10

      Pages: 838-843

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079
  • [Journal Article] RECK negatively regulates matrix metalloproteinase-9 transcription.2009

    • Author(s)
      Takagi, S., Simizu, S., Osada, H.
    • Journal Title

      Cancer Res. 69

      Pages: 1502-1508

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Journal Article] On-chip fragment-based approach for discovery of high-affinity bivalent inhibitors2009

    • Author(s)
      Miyazaki, I., Simizu, S., Ishida, K., Osada, H.
    • Journal Title

      Chembiochem 10

      Pages: 838-843

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Journal Article] Deamino-hydroxy-phoslactomycin B, a biosynthetic precursor of phoslactomycin, induces myeloid differentiation in HL-60 cells2009

    • Author(s)
      Simizu, S., et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 383

      Pages: 406-410

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Journal Article] 分子細胞学的解析2009

    • Author(s)
      清水史郎, 辻田和彦, 長田裕之
    • Journal Title

      日本臨牀 67増刊号1

      Pages: 143-147

    • Data Source
      KAKENHI-PROJECT-18681035
  • [Journal Article] A cell-based screening to detect inhibitors of BRAF signaling pathway2009

    • Author(s)
      Asami, Y., Mori, M., Koshino, H., Sekiyama, Y., Teruya, T., Simizu, S., Usui, T. & Osada, H
    • Journal Title

      Journal of Antibiotics

      Volume: 62 Issue: 2 Pages: 105-107

    • DOI

      10.1038/ja.2008.17

    • NAID

      10030634719

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Journal Article] Polo-like kinase 1 phosphorylates and regulates Bcl-xL during pironetin-induced apoptosis2009

    • Author(s)
      Tamura, Y., Simizu, S., Muroi, M., Takagi, S., Kawatani, M., Watanabe, N. & Osada, H
    • Journal Title

      Oncogene

      Volume: 28 Issue: 1 Pages: 107-116

    • DOI

      10.1038/onc.2008.368

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Journal Article] Robust and systematic drug screening method using chemical arrays and the protein library:identification of novel inhibitors of carbonic anhydrase II.2008

    • Author(s)
      Miyazaki, I., Simizu, S., Ichimiya, H., Kawatani, M., Osada, H.
    • Journal Title

      Biosci.Biotechnol.Biochem. 72

      Pages: 2739-2749

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Journal Article] Requirement of the conserved, hydrophobic C-terminus region for the activation of heparanase2008

    • Author(s)
      Lai, N. S., Simizu, S., Morisaki, D., Muroi, M. & Osada, H
    • Journal Title

      Experimental Cell Research

      Volume: 314 Issue: 15 Pages: 2834-2845

    • DOI

      10.1016/j.yexcr.2008.07.004

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Journal Article] 分子細胞学的解析2008

    • Author(s)
      清水 史郎, 他
    • Journal Title

      日本臨牀 増刊号1 がん薬物療法学 67

      Pages: 143-147

    • Data Source
      KAKENHI-PROJECT-18681035
  • [Journal Article] 分子細胞学的解析2008

    • Author(s)
      清水 史郎 他
    • Journal Title

      日本臨牀 増刊号1 がん薬物療法学 67

      Pages: 143-147

    • Data Source
      KAKENHI-PLANNED-20113008
  • [Journal Article] Robust and systematic drug screening method using chemical arrays and the protein library: identification of novel inhibitors of carbonic anhydrase II2008

    • Author(s)
      Miyazaki, I., Simizu, S., Ichimiya, H., Kawatani, M. & Osada, H
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 72 Pages: 2739-2749

    • NAID

      10027533381

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/18838795

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Journal Article] Requirement of the conserved, hydrophobic C-terminus region for the activation of heparanase2008

    • Author(s)
      Lai, N. S., Simizu, S., Morisaki, D., Muroi, M., Osada, H.
    • Journal Title

      Exp. Cell Res. 314

      Pages: 2834-2845

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Journal Article] Requirement of the conserved, hydrophobic C-terminus region for the activation of heparanase.2008

    • Author(s)
      Simizu, S. (5名中2番目), Osada, H. (5名中5番目)
    • Journal Title

      Exp. Cell Res 314

      Pages: 2834-2845

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079
  • [Journal Article] Synthesis and biological activities of reveromycin A and spirofungin A derivatives.2008

    • Author(s)
      Shimizu T., et al.
    • Journal Title

      Bioorg. Med. Chem. Lett. 18

      Pages: 3576-3760

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079
  • [Journal Article] Robust and systematic drug screening method using chemical arrays and the protein library : identification of novel inhibitors of carbonic anhydrase II2008

    • Author(s)
      Miyazaki, I., Simizu, S., Ichimiya, H., Kawatani, M., Osada, H.
    • Journal Title

      Biosci. Biotechnol. Biochem. 72

      Pages: 2739-2749

    • NAID

      10027533381

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Journal Article] Involvement of disulfide bond formation in the activation of heparanase.2007

    • Author(s)
      Simizu, S. (7名中1番目), Muroi, M. (7名中3番目), Osada, H. (7名中7番目)
    • Journal Title

      Cancer Res. 67

      Pages: 7841-7849

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079
  • [Journal Article] Involvement of disulfide bond formation in the activation of heparanase2007

    • Author(s)
      Simizu, S., Suzuki, T., Muroi, M., Lai, N. S., Takagi, S., Dohmae, N., Osada, H.
    • Journal Title

      Cancer Res. 67

      Pages: 7841-7849

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Journal Article] バイオプローブ開発からケミカルバイオロジー研究へ2007

    • Author(s)
      清水史郎, 長田裕之
    • Journal Title

      化学工業 58

      Pages: 335-339

    • Data Source
      KAKENHI-PROJECT-18681035
  • [Journal Article] Synthesis of (+)-vinblastine and its analogues2007

    • Author(s)
      Miyazaki, T., Yokoshima, S., Simizu, S., Osada, H., Tokuyama, H., Fukuyama, T.
    • Journal Title

      Org. Lett. 9

      Pages: 4737-4740

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Journal Article] Involvement of disulfide bond formation in the activation of heparanase2007

    • Author(s)
      Simizu, S., et. al.
    • Journal Title

      Cancer Research 67

      Pages: 7841-7849

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Journal Article] Involvement of disulfide bond formation in the activation of heparanase.2007

    • Author(s)
      Simizu S., et. al.
    • Journal Title

      Cancer Res. 67

      Pages: 7841-7849

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079
  • [Journal Article] Photo-cross-linked small-molecule microarrays as chemical genomic tools for dissecting protein-ligand interactions2006

    • Author(s)
      Kanoh, N., Asami, A., Kawatani, M., Honda, K., Kumashiro, S., Takayama, H., Simizu, S., Amemiya, T., Kondoh, Y., Hatakeyama, S., Tsuganezawa, K., Utata, R., Tanaka, A., Yokoyama, S., Tashiro, H., Osada, H.
    • Journal Title

      Chem. Asian J. 1

      Pages: 787-797

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Journal Article] Photo-cross-linked small-molecule affinity matrix for facilitating forward and reverse chemical genetics2005

    • Author(s)
      Kanoh, N., Honda, K., Simizu, S., Muroi, M., Osada, H.
    • Journal Title

      Angewandte Chemie International Edition 44

      Pages: 3559-3562

    • Data Source
      KAKENHI-PROJECT-16710164
  • [Journal Article] Phoslactomycin targets cysteine-269 of the protein phosphatase 2A catalytic subunit in cells2005

    • Author(s)
      Teruya, T., Simizu, S., Kanoh, N., Osada, H.
    • Journal Title

      FEBS Letters 579

      Pages: 2463-2468

    • Data Source
      KAKENHI-PROJECT-16710164
  • [Journal Article] RECK-mediated suppression of tumor cell invasion is regulated by glycosylation in human tumor cell lines.2005

    • Author(s)
      Simizu, S. (4名中1番目), Osada, H. (4名中4番目)
    • Journal Title

      Cancer Res. 65

      Pages: 7455-7461

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079
  • [Journal Article] RECK-mediated suppression of tumor cell invasion is regulated by glycosylation in human tumor cell lines.2005

    • Author(s)
      S.Simizu et al.
    • Journal Title

      Cancer Res. 65

      Pages: 7455-7461

    • Data Source
      KAKENHI-PROJECT-17016079
  • [Journal Article] Phoslactomycin targets cysteine-269 of the protein phosphatase 2A catalytic subunit in cells.2005

    • Author(s)
      Simizu, S. (4名中2番目), Kanoh, N. (4名中3番目), Osada, H. (4名中4番目)
    • Journal Title

      FEBS Lett. 579

      Pages: 2463-2468

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079
  • [Journal Article] Photo-crosslinked small molecule affinity matrix for facilitating forward and reverse chemical genetics.2005

    • Author(s)
      Kanoh, N. (5名中1番目), Simizu, S. (5名中3番目), Muroi, M. (5名中4番目), Osada, H. (5名中5番目)
    • Journal Title

      Angew. Chem. Int. Ed. 44

      Pages: 3559-3562

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016079
  • [Journal Article] RECK-mediated suppression of tumor cell invasion is regulated by glycosylation in human tumor cell lines.2005

    • Author(s)
      Simizu, S., Takagi, S., Tamura, Y., Osada, H.
    • Journal Title

      Cancer Research 65

      Pages: 7455-7461

    • Data Source
      KAKENHI-PROJECT-16710164
  • [Journal Article] The phosphorylation status and anti-apoptotic activity of Bcl-2 are regulated by ERK and protein phosphatase 2A on the mitochondria2004

    • Author(s)
      Tamura, Y., Simizu, S., Osada, H.
    • Journal Title

      FEBS Letters 569

      Pages: 249-255

    • Data Source
      KAKENHI-PROJECT-16710164
  • [Journal Article] Structure-based design of a selective heparanase inhibitor as an antimetastatic agent2004

    • Author(s)
      Ishida, K., Hirai, G., Murakami, K., Teruya, T., Simizu S., Sodeoka, M., Osada, H.
    • Journal Title

      Molecular Cancer Therapeutics 3

      Pages: 1069-1077

    • Data Source
      KAKENHI-PROJECT-16710164
  • [Journal Article] Kaurene diterpene induces apoptosis in human leukemia cells partly through a caspase-8-dependent pathway2004

    • Author(s)
      Kondoh, M., Suzuki, I., Sato, M., Nagashima, F., Simizu, S., Harada, M., Fujii, M., Osada, H., Asakawa, Y., Watanabe, Y.
    • Journal Title

      The Journal of Pharmacology and Experimental Therapeutics 311

      Pages: 115-122

    • Data Source
      KAKENHI-PROJECT-16710164
  • [Journal Article] Heparanase as a molecular target of cancer chemotherapy2004

    • Author(s)
      Simizu, S., Ishida, K., Osada, H.
    • Journal Title

      Cancer Science 95

      Pages: 553-558

    • NAID

      10014196678

    • Data Source
      KAKENHI-PROJECT-16710164
  • [Presentation] C-mannosylation: 酵素と基質の探索2021

    • Author(s)
      清水 史郎
    • Organizer
      山口大学大学院医学系研究科 薬理学講座・ラボセミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] AML既承認薬によるALK阻害剤耐性克服の発見2021

    • Author(s)
      水田 隼斗、岡田 康太郎、竹本 愛、丸山 航平、清水 史郎、藤田 直也、片山 量平
    • Organizer
      文部科学省科学研究費助成事業新学術領域研究「学術研究支援基盤形成」コホート・生体試料支援プラットフォーム 令和2年度若手支援研究成果発表会
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] ケミカルバイオロジー研究による血管擬態解明2021

    • Author(s)
      清水 史郎
    • Organizer
      日本ケミカルバイオロジー学会・産学連携委員会「ケミカルバイオロジーの技術革新」・研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] FGL1におけるグルコシルガラクトシルヒドロキシ化の機構解析2020

    • Author(s)
      森 研人、鈴木 健裕、三浦 一輝、堂前 直、清水 史郎
    • Organizer
      日本農芸化学会関東支部会2020年度大会
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] ヒトIsthmin-1のC型糖修飾によるN型糖鎖修飾と分泌の制御2020

    • Author(s)
      吉本 哲、鈴木 健裕、堂前 直、清水 史郎
    • Organizer
      日本農芸化学会関東支部会2020年度大会
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] ADAMTS4におけるC-mannosylationの機能解析2020

    • Author(s)
      三浦 一輝、鈴木 健裕、堂前 直、清水 史郎
    • Organizer
      第39回日本糖質学会年会
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] Madangamineの構造活性相関研究および作用機序の解明2020

    • Author(s)
      河野 紗也香、三浦 一輝、佐藤 隆章、千田 憲孝、清水 史郎
    • Organizer
      日本農芸化学会関東支部会2020年度大会
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] C型糖修飾によってヒトIsthmin-1のN型糖鎖修飾は制御されている2020

    • Author(s)
      吉本 哲、片山 和洸、鈴木 健裕、堂前 直、清水 史郎
    • Organizer
      第39回日本糖質学会年会
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] 血管新生阻害剤TNP-470 はヒトがん細胞の血管擬態形成を抑制する2020

    • Author(s)
      清水 翔太、川原 遼太、三浦 一輝、清水 史郎
    • Organizer
      日本がん分子標的治療学会 第24回学術集会
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] FGL1のグルコシルガラクトシルヒドロキシ化とその責任酵素探索2020

    • Author(s)
      森 研人、鈴木 健裕、三浦 一輝、堂前 直、清水 史郎
    • Organizer
      第39回日本糖質学会年会
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] C-mannosylationがADAMTS4機能に与える影響の解析2020

    • Author(s)
      三浦 一輝、鈴木 健裕、堂前 直、清水 史郎
    • Organizer
      日本農芸化学会関東支部会2020年度大会
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] 乳がん細胞の血管擬態におけるErbB4の機能解析2020

    • Author(s)
      川原 遼太、清水 史郎
    • Organizer
      第29回 日本がん転移学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] Drug sensitivity analysis of the ALK-TKI resistant cells for modeling the resistant mutants emergence2020

    • Author(s)
      水田 隼斗、大原 智子、小池 清恵、岩見 真吾、清水 史郎、藤田 直也、片山 量平
    • Organizer
      第79回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] 細胞接着因子CEACAM1による血管擬態形成の抑制2019

    • Author(s)
      林 聡一郎、長田 祥征、三浦 一輝、清水 史郎
    • Organizer
      日本がん分子標的治療学会 第23回学術集会
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] 低分子化合物による細胞機能の解析2019

    • Author(s)
      清水 史郎
    • Organizer
      特別講義 長浜バイオ大学
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] Involvement of C-mannosylation of Isthmin-1 in the its secretion2019

    • Author(s)
      Siro Simizu, Satoshi Yoshimoto, Kazuhiro Katayama, Takehiro Suzuki, Kazuki Miura, Naoshi Dohmae
    • Organizer
      25th International Symposium on Glycoconjugates
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] Fibrinogen C-terminal domainにおけるC型糖鎖修飾の発見2019

    • Author(s)
      長田 祥征、水田 隼斗、森 研人、鈴木 健裕、三浦 一輝、堂前 直、清水 史郎
    • Organizer
      日本農芸化学会関東支部会2019年度大会
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] Elucidation of the novel biological activities and molecular target of vibsanin A analog2019

    • Author(s)
      Kazuki Miura, Siro Simizu
    • Organizer
      The 10th Japan-Korea Chemical Biology Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] C型糖修飾によるIsthmin-1への影響2019

    • Author(s)
      吉本 哲、片山 和洸、鈴木 健裕、三浦 一輝、堂前 直、清水 史郎
    • Organizer
      第38回日本糖質学会年会
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] 血管擬態形成はCEACAM1によって制御される2019

    • Author(s)
      清水 史郎、林 聡一郎
    • Organizer
      第28回 日本がん転移学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] FGL1のグルコシルガラクトシルヒドロキシ化が機能に及ぼす影響2019

    • Author(s)
      森 研人、鈴木 健裕、三浦 一輝、堂前 直、清水 史郎
    • Organizer
      第38回日本糖質学会年会
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] ヒトがん細胞においてMFAP4はC型糖修飾を受ける2019

    • Author(s)
      長田 祥征、鈴木 健裕、三浦 一輝、堂前 直、清水 史郎
    • Organizer
      第38回日本糖質学会年会
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] Microfibril-associated glycoprotein 4 is C-mannosylated in human cells2019

    • Author(s)
      Yushiyuki Osada, Takehiro Suzuki, Kazuki Miura, Naoshi Dohmae, Siro Simizu
    • Organizer
      25th International Symposium on Glycoconjugates
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] C-mannosylation: identification of novel enzymes and substrates2019

    • Author(s)
      Siro Simizu
    • Organizer
      The 7th Symposium RIKEN-Max Planck Joint Research Center
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] Vibsanin Aの構造活性相関とその誘導体が持つ新規生物活性の評価2019

    • Author(s)
      三浦 一輝、松木 渉、高尾 賢一、清水 史郎
    • Organizer
      日本ケミカルバイオロジー学会 第14回年会
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] Vibsanin A誘導体の新規生物活性評価および作用標的の同定2019

    • Author(s)
      三浦 一輝、松木 渉、高尾 賢一、清水 史郎
    • Organizer
      日本農芸化学会関東支部会2019年度大会
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] RAMP1 is C-mannosylated at Trp56 in cultured human cells2019

    • Author(s)
      Hayato Mizuta, Ayane Takakusaki, Takehiro Suzuki, Keisuke Otake, Kazuki Miura, Naoshi Dohmae, Siro Simizu
    • Organizer
      25th International Symposium on Glycoconjugates
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] ヒト死後脳の神経細胞におけるLINE-1プロモーターのエピジェネティック修飾状態の検討2019

    • Author(s)
      渡邊 理紗、文東 美紀、上田 順子、村田 唯、石井 貴男、鵜飼 渉、橋本 恵理、笠井 清登、清水 史郎、加藤 忠史、岩本 和也
    • Organizer
      第41回日本生物学的精神医学会
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] Cytosporolide C and its analog inhibited activities of topoisomerases and tumor cell growth2019

    • Author(s)
      川原 遼太、清水 史郎
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] インテグリンβ1は血管擬態形成に重要な因子である2018

    • Author(s)
      川原 遼太、丹羽 祐貴、清水 史郎
    • Organizer
      第27回 日本がん転移学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] CCN1におけるglucosyl-galactosyl-hydroxylationの機能解析2018

    • Author(s)
      石沢 雄大、丹羽 祐貴、鈴木 健裕、堂前 直、清水 史郎
    • Organizer
      第37回日本糖質学会年会
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] C-mannosylationによるR-spondin2 の機能制御2018

    • Author(s)
      水田 隼斗、丹羽 祐貴、堂前 直、清水 史郎
    • Organizer
      日本がん分子標的治療学会 第22回学術集会
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] R-spondin1 におけるリン酸化の機能解析2018

    • Author(s)
      西谷 拓海, 鈴木 健裕, 丹羽 祐貴, 三浦 一輝, 堂前 直, 清水 史郎
    • Organizer
      日本農芸化学会関東支部会2018年度大会
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] Cytosporolide類の細胞増殖抑制活性における責任分子標的の同定2018

    • Author(s)
      大竹 慶祐、室井 誠、丹羽 祐貴、宮嵜 奏、笹澤 有紀子、長田 裕之、清水 史郎
    • Organizer
      日本がん分子標的治療学会 第22回学術集会
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] Identification of molecular targets on inhibitory activity of cell proliferation by cytosporolide analogs2018

    • Author(s)
      Keisuke Otake, Makoto Muroi, Yuki Niwa, Ken-ichi Takao, Hiroyuki Osada, Siro Simizu
    • Organizer
      The 9th Japan-Korea Chemical Biology Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] トポロジー解析によるDPY19L1活性中心の探索2018

    • Author(s)
      横山 典弘、柳原 凌太郎、小松 良亮、三浦 一輝、丹羽 祐貴、清水 史郎
    • Organizer
      第37回日本糖質学会年会
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] トポロジー解析によるDPY19L1のC-mannosyltransferase活性中心の探索2018

    • Author(s)
      横山 典弘, 柳原 凌太郎, 三浦 一輝, 丹羽 祐貴, 清水 史郎
    • Organizer
      日本農芸化学会関東支部会2018年度大会
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] Functional analysis of the promoter region of C-mannosyltransferase DPY19L32018

    • Author(s)
      Satoshi Yoshimoto, Siro Simizu
    • Organizer
      29th International Carbohydrate Symposium in 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] ヒトC型糖転移酵素DPY19L3のプロモーター解析2018

    • Author(s)
      吉本 哲、三浦 一輝、清水 史郎
    • Organizer
      日本農芸化学会関東支部会2018年度大会
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] C-mannosylation-基質と酵素の探索2018

    • Author(s)
      清水 史郎
    • Organizer
      日本農芸化学会中部支部 第183回例会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] Vibsanin A誘導体の生物活性評価および標的分子の同定2018

    • Author(s)
      三浦 一輝、松木 渉、高尾 賢一、清水 史郎
    • Organizer
      日本農芸化学会関東支部会2018年度大会
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] C-mannosylation of R-spondin2 as a potential cancer biomarker2018

    • Author(s)
      水田 隼斗、丹羽 祐貴、清水 史郎
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] Glucosy-galactosyl-hydroxylation of CCN1 regulates its secretion2018

    • Author(s)
      Yudai Ishizawa, Yuki Niwa, Takehiro Suzuki, Naoshi Dohmae, Siro Simizu
    • Organizer
      29th International Carbohydrate Symposium in 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06137
  • [Presentation] Identification of a compound that regulates autophagy in cells2015

    • Author(s)
      Siro Simizu
    • Organizer
      International Mini Symposium on Chemical Biology of Natural Products
    • Place of Presentation
      慶應義塾大学(神奈川県・横浜市)
    • Year and Date
      2015-03-24
    • Invited
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] Regulation of Wnt signaling by glycosylation2014

    • Author(s)
      Siro Simizu
    • Organizer
      Universiti Sains Malaysia Public Lecture
    • Place of Presentation
      Penang, Malaysia
    • Invited
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] 新規alkylglutarimide化合物による成人T細胞白血病細胞のNF-kappa B阻害と選択的アポトーシス誘導2013

    • Author(s)
      宇梶 珠未、竹入 雅敏、伊藤 あゆみ、清水 史郎、 梅澤 一夫
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] Secretion of R-spondin1 is regulated by C-mannosylation2013

    • Author(s)
      Yuki Niwa, Siro Simizu
    • Organizer
      AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
    • Place of Presentation
      Boston, MA; USA
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] Involvement of glycosylation in hyaluronidase1 functions2013

    • Author(s)
      Siro Simizu, Yuki Goto, Yuki Niwa
    • Organizer
      9th International Conference on Hyaluronan
    • Place of Presentation
      Oklahoma City, OK; USA
    • Invited
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] Induction of NF-kappa B and induction of selective apoptosis by novel alkylglutarimide compounds in adult T-cell leukemia cells2013

    • Author(s)
      宇梶 珠未、竹入 雅敏、伊藤 あゆみ、清水 史郎、梅澤 一夫
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] Regulation of R-spondin1 secretion by C-mannosylation2013

    • Author(s)
      丹羽 祐貴、清水 史郎
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] Role of glycosylation on Hyaluronidase1 functions2013

    • Author(s)
      後藤 祐貴、丹羽 祐貴、清水 史郎
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] 細胞内ロジスティクス研究におけるケミカルバイオロジーの役割2013

    • Author(s)
      清水 史郎
    • Organizer
      新学術領域研究「細胞内ロジスティクス」終了シンポジウム
    • Place of Presentation
      淡路島
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] 海洋産マクロリドBiselyngbyaside類の構造と生物活性2013

    • Author(s)
      森田 真布、大野 修、矢守 隆夫、丹羽 祐貴、清水 史郎、末永 聖武
    • Organizer
      日本農芸化学会関東支部会2013年度大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] Conophyllineによるオートファジー誘導2013

    • Author(s)
      笹澤 有紀子、梅澤 一夫、清水 史郎
    • Organizer
      日本ケミカルバイオロジー学会 第8回年会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] NF-κB阻害剤(-)-DHMEQはMMP-2依存性のマスト細胞浸潤を抑制する2013

    • Author(s)
      野間成人、清水史郎、梅澤一夫
    • Organizer
      第17回がん分子標的治療学会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] Suppression of NO-induced beta cell death by (-)-DHMEQ via activation of Nrf2-ARE pathway and alteration of MAPK activity2013

    • Author(s)
      K. Umezawa, T. Ukaji, A. Ogasawara, S. Simizu and I. Takei
    • Organizer
      49th Annual European Association for the Study of Diabetes (EASD) Meeting 2013
    • Place of Presentation
      Barcelona, Spain
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] R-spondin1の機能に与えるC-mannosylationの役割2013

    • Author(s)
      丹羽 祐貴、清水 史郎
    • Organizer
      第22回 日本がん転移学会学術集会・総会
    • Place of Presentation
      松本
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] TPh A 誘導体の破骨細胞分化に及ぼす影響と構造活性相関解析2013

    • Author(s)
      森下 佳典、笹澤 有紀子、杉野 公美、川谷 誠、長田 裕之、清水 史郎
    • Organizer
      日本農芸化学会関東支部会2013年度大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] Neuroprotective effect of conophylline in cellular model of Parkinson’s disease2013

    • Author(s)
      Yukiko Sasazawa, Kazuo Umezawa, Siro Simizu
    • Organizer
      International Symposium on Mitochondria 2013
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] Conophylline標的タンパク質ARL6ip1の小胞体におけるトポロジー解析2013

    • Author(s)
      黒田 将広、宇梶 珠未、笹澤 有紀子、清水 史郎
    • Organizer
      日本ケミカルバイオロジー学会 第8回年会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] オートファジーを制御する新規化合物の探索2013

    • Author(s)
      田中 敦史、近藤 恭光、清水 史郎、斎藤 臣雄、長田 裕之、野田 健司、吉森 保
    • Organizer
      第65回 日本細胞生物学会大会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] NF-kappa B阻害剤(-)-DHMEQはMMP-2依存性のマスト細胞浸潤を抑制する2013

    • Author(s)
      野間 成人、清水 史郎、梅澤 一夫
    • Organizer
      日本がん分子標的治療学会 第16回学術集会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] Hyaluronidase1 activity and secretion are regulated by C-mannosylation2013

    • Author(s)
      Simizu, S., et al.
    • Organizer
      9th AACRJCA Joint Conference
    • Place of Presentation
      Hyatt Regency Maui (アメリカ)
    • Year and Date
      2013-02-24
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] Hyaluronidase1 activity and secretion are regulated by C-mannosylation2013

    • Author(s)
      Simizu, S., et al.
    • Organizer
      9th AACR-JCA Joint Conference
    • Place of Presentation
      Hyatt Regency Maui(アメリカ)
    • Year and Date
      2013-02-24
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Presentation] Hyaluronidase1 activity and secretion are regulated by C-mannosylation2013

    • Author(s)
      Simizu, S., et al.
    • Organizer
      9th AACR-JCA Joint Conference
    • Place of Presentation
      Hyatt Regency Maui、アメリカ
    • Year and Date
      2013-02-24
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Presentation] conophyllineによる神経保護効果の解2013

    • Author(s)
      笹澤 有紀子、梅澤 一夫、清水 史郎
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] がん分子標的研究の今昔2012

    • Author(s)
      清水史郎
    • Organizer
      理研セミナー
    • Place of Presentation
      理化学研究所、埼玉県
    • Year and Date
      2012-07-13
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Presentation] がん分子標的研究の今昔2012

    • Author(s)
      清水史郎
    • Organizer
      理研セミナー
    • Place of Presentation
      理化学研究所(埼玉県)(招待講演)
    • Year and Date
      2012-07-13
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] DTCM-glutarimideによる成人T細胞白血病におけるRelBの分解とアポトーシス誘導2012

    • Author(s)
      伊藤あゆみ,清水史郎、梅澤一夫
    • Organizer
      日本癌学会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] Inhibition of canonical and noncanonical NF-κBs by (-)-DHMEQ2012

    • Author(s)
      K. Horie, K. Sidthipong, M. Takeiri, S. Simizu, and K. Umezawa
    • Organizer
      The 17th World Congress on Advances in Oncology, and 15th International Symposium on Molecular Medicine
    • Place of Presentation
      Crete, Greece
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] がん分子標的研究の今昔2012

    • Author(s)
      清水史郎
    • Organizer
      理研セミナー
    • Place of Presentation
      理化学研究所(埼玉県)
    • Year and Date
      2012-07-13
    • Invited
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Presentation] Regulation of melanoma cell migration by Pirin revealed by an approach of chemical biology2011

    • Author(s)
      清水史郎、長田裕之
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場:名古屋(招待講演)
    • Year and Date
      2011-10-05
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Presentation] (-)-DHMEQによるnoncanonical NF-kappa Bの新規阻害機構2011

    • Author(s)
      竹入雅敏、清水史郎、梅澤一夫, ほか
    • Organizer
      日本ケミカルバイオロジー学会
    • Place of Presentation
      神奈川
    • Year and Date
      2011-05-23
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] ケミカルバイオロジーと細胞内ロジスティクス研究の融合2011

    • Author(s)
      清水史郎、長田裕之
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館:京都(招待講演)
    • Year and Date
      2011-09-21
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Presentation] Protein disulfide isomeraseによるMMP-9の活性化機構の解析2011

    • Author(s)
      清水史郎
    • Organizer
      第20回日本がん転移学会学術集会
    • Place of Presentation
      アクトシティ浜松:浜松
    • Year and Date
      2011-07-01
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Presentation] Galectin-3 binding proteinの作用と発現におけるNF-κBの関与。Regulation of Galectin-3 binding protein expression by NF-kappa B2011

    • Author(s)
      野間成人、清水史郎、梅澤一夫
    • Organizer
      日本分子標的がん治療学会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-22
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] 化合物アレイを用いたタンパク質阻害剤の網羅的探索2011

    • Author(s)
      清水史郎、長田裕之
    • Organizer
      日本薬学会第131回年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-29
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Presentation] 化合物アレイを用いたタンパク質阻害剤の網羅的探索2011

    • Author(s)
      清水史郎、長田裕之
    • Organizer
      日本薬学会第131回年会
    • Place of Presentation
      ツインメッセ静岡、静岡
    • Year and Date
      2011-03-29
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Presentation] Pirin によるメラノーマ細胞の遊走制御と阻害剤探索2010

    • Author(s)
      清水史郎
    • Organizer
      第19回日本がん転移学会学術集会
    • Place of Presentation
      金沢
    • Year and Date
      2010-06-16
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Presentation] Pirinによるメラノーマ細胞の遊走制御と阻害剤探索2010

    • Author(s)
      清水史郎
    • Organizer
      第19回日本がん転移学会学術集会・総会
    • Place of Presentation
      金沢市文化ホール:金沢市
    • Year and Date
      2010-06-16
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Presentation] A small molecule inhibitor of Pirin that suppresses tumor cell migration.2009

    • Author(s)
      Simizu, S.
    • Organizer
      2009 AACR-NCI-EORTC International Conference
    • Place of Presentation
      Boston, U.S. A
    • Data Source
      KAKENHI-PROJECT-17016079
  • [Presentation] 最先端創薬システム:分子標的治療薬開発のためのケミカルバイオロジー2009

    • Author(s)
      清水史郎
    • Organizer
      第13回日本がん分子標的治療学会学術集会
    • Place of Presentation
      ホテルクレメント徳島(徳島)
    • Year and Date
      2009-06-25
    • Data Source
      KAKENHI-PROJECT-17016079
  • [Presentation] 化合物アレイを用いた抗がん剤スクリーニング系の開発2009

    • Author(s)
      清水史郎, 他
    • Organizer
      第13回日本がん分子標的治療学会学術集会
    • Place of Presentation
      ホテルクレメント徳島:徳島市
    • Year and Date
      2009-06-26
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Presentation] Discovery of small-molecule inhibitors by chemical array.2009

    • Author(s)
      清水 史郎, 他
    • Organizer
      RIKEN 2009 Joint retreat
    • Place of Presentation
      熱海ニューフジヤホテル (熱海)
    • Data Source
      KAKENHI-PROJECT-17016079
  • [Presentation] On-chip fragment-based approach for new tool of antitumor drug design2009

    • Author(s)
      Miyazaki, I., Simizu, S., Osada, H.
    • Organizer
      AACR-ACS Joint Conference on Chemistry in Cancer Research
    • Place of Presentation
      アメリカ・ニューオーリンズ
    • Year and Date
      2009-02-10
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Presentation] 最先端創薬システム:分子標的治療薬開発のためのケミカルバイオロジー2009

    • Author(s)
      清水史郎, 他
    • Organizer
      第13回日本がん分子標的治療学会学術集会
    • Place of Presentation
      ホテルクレメント徳島:徳島市
    • Year and Date
      2009-06-25
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Presentation] 最先端創薬システム:分子標的治療薬開発のためのケミカルバイオロジー2009

    • Author(s)
      清水史郎、宮崎功、長田裕之
    • Organizer
      第13回日本がん分子標的治療学会学術集会
    • Place of Presentation
      徳島
    • Year and Date
      2009-06-25
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Presentation] 化合物アレイを使用した抗がん剤のスクリーニング法2009

    • Author(s)
      清水史郎, 他
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜:横浜市
    • Year and Date
      2009-10-01
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Presentation] Establishment of novel antitumor drugs screening method by using chemical array2009

    • Author(s)
      Simizu, S., et al.
    • Organizer
      AACR-ACS Joint Conference on Chemistry in Cancer Research
    • Place of Presentation
      米国 : Westin New Orleans Canal Place
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Presentation] 化合物アレイを用いた抗がん剤スクリーニング法の開発2009

    • Author(s)
      清水史郎
    • Organizer
      第13回日本がん分子標的治療学会学術集会
    • Place of Presentation
      ホテルクレメント徳島(徳島)
    • Year and Date
      2009-06-26
    • Data Source
      KAKENHI-PROJECT-17016079
  • [Presentation] 化合物アレイを使用した抗がん剤のスクリーニング法2009

    • Author(s)
      清水史郎、宮崎功、長田裕之
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Presentation] Establishment of novel antitumor drugs screening method by using chemical array.2009

    • Author(s)
      Simizu, S.
    • Organizer
      AACR-ACS Joint Conference on Chemistry in Cancer Research
    • Place of Presentation
      New Orleans, USA.
    • Data Source
      KAKENHI-PROJECT-17016079
  • [Presentation] 化合物アレイを使用した抗がん剤のスクリーニング法2009

    • Author(s)
      清水史郎
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Data Source
      KAKENHI-PROJECT-17016079
  • [Presentation] Establishment of novel antitumor drugs screening method by using chemical array2009

    • Author(s)
      Simizu, S., Miyazaki, I., Osada, H.
    • Organizer
      AACR-ACS Joint Conference on Chemistry in Cancer Research
    • Place of Presentation
      アメリカ、ニューオーリンズ
    • Year and Date
      2009-02-09
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Presentation] Establishment of novel antitumor drugs screening method by using chemical array2009

    • Author(s)
      Simizu, S., et al.
    • Organizer
      AACR-ACS Joint Conference on Chemistry in Cancer Research
    • Place of Presentation
      米国 : Westin New Orleans Canal Place
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Presentation] A small molecule inhibitor of Pirin that suppresses tumor cell migration2009

    • Author(s)
      清水史郎
    • Organizer
      2009 AACR-NCI-EORTC International Conference
    • Place of Presentation
      Boston, U.S.A
    • Data Source
      KAKENHI-PROJECT-17016079
  • [Presentation] Establishment of novel antitumor drugsscreening method by using chemical array2009

    • Author(s)
      Simizu, S., Miyazaki, I., Osada, H.
    • Organizer
      AACR-ACS Joint Conference on Chemistry in Cancer Research
    • Place of Presentation
      アメリカ・ニューオリンズ
    • Year and Date
      2009-02-09
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Presentation] ヘパラナーゼ結合タンパク質の探索と活性化機構の解析2008

    • Author(s)
      清水 史郎, 他
    • Organizer
      第12回がん分子標的治療研究会
    • Place of Presentation
      学術総合センター (東京)
    • Data Source
      KAKENHI-PROJECT-17016079
  • [Presentation] RECK suppressed MMP-9 mRNA due to the decrease of Fra-1 binding to MMP-9 promoter region2008

    • Author(s)
      高木聡, 清水史郎, 長田裕之
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Presentation] Activation and function of heparanase: roles of post-translational modifications.2008

    • Author(s)
      Simizu, S.
    • Organizer
      International Symposium on System Glycobiology
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2008-12-05
    • Data Source
      KAKENHI-PROJECT-17016079
  • [Presentation] GeneライブラリーGLORIAの構築2008

    • Author(s)
      一宮治美, 清水史郎, 宮崎功, 長田裕之
    • Organizer
      第3回日本ケミカルバイオロジー研究会年会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-20
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Presentation] Activation and function of heparanase: roles of post-translational modifications2008

    • Author(s)
      Simizu, S., et al.
    • Organizer
      International Symposium on Systems Glycobiology
    • Place of Presentation
      東京 : 東京カンファレンスセンター
    • Year and Date
      2008-12-05
    • Data Source
      KAKENHI-PLANNED-20113008
  • [Presentation] ヘパラナーゼ結合タンパク質の探索と活性化機構の解析2008

    • Author(s)
      清水 史郎, 他
    • Organizer
      第12回がん分子標的治療研究会
    • Place of Presentation
      東京 : 学術総合センター
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Presentation] Identification of heparanase- interacting proteins of human fibrosarcoma cells2008

    • Author(s)
      清水史郎, Lai Ngit Shin, 室井誠, 長田裕之
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Presentation] ヘパラナーゼ結合タンパク質の探索と活性化機構の解析2008

    • Author(s)
      清水史郎, Lai Ngit Shin, 室井誠, 長田裕之
    • Organizer
      第12回がん分子標的治療研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-26
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Presentation] Activation and function of heparanase: roles of post-translational modifications2008

    • Author(s)
      Simizu, S., Lai, N. S., Osada, H.
    • Organizer
      International Symposium on Systems Glycobiology
    • Place of Presentation
      東京
    • Year and Date
      2008-12-05
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Presentation] 化合物アレイスクリーニング系の構築と新規CAIIリガンドの検出2008

    • Author(s)
      宮崎功, 清水史郎, 一宮治美, 長田裕之
    • Organizer
      第3回日本ケミカルバイオロジー研究会年会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-19
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Presentation] ヒト線維肉腫細胞株におけるヘパラナーゼ結合タンパク質の探索と同定2008

    • Author(s)
      清水 史郎, 他
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場 (名古屋)
    • Data Source
      KAKENHI-PROJECT-17016079
  • [Presentation] 理研天然化合物バンク(NPDepo)におけるリガンドスクリーニング2008

    • Author(s)
      斎藤臣雄, 米田新, 宮崎功, 清水史郎, 近藤恭光, 松井南, 長田裕之
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-27
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Presentation] ヒト線維肉腫細胞株におけるヘパラナーゼ結合タンパク質の探索と同定2008

    • Author(s)
      清水 史郎, 他
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      愛知 : 名古屋国際会議場
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Presentation] Activation and function of heparanase: roles of post-translational modifications2008

    • Author(s)
      Simizu, S., et al.
    • Organizer
      International Symposium on Systems Glycobiology
    • Place of Presentation
      東京 : 東京カンファレンスセンター
    • Year and Date
      2008-12-05
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Presentation] A novel chemical microarray platform for searching anticancer drugs2007

    • Author(s)
      Simizu, S., et. al.
    • Organizer
      第66回 日本癌学会総会
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Presentation] Phosphorylation of Bcl-xL by polo-like kinase l results in the inactivation of the anti-apoptotic activity during tubulin binder-induced apoptosis2007

    • Author(s)
      Simizu, S., et. al.
    • Organizer
      AACR-NCI-EORTC International Conference"Molecular Targets and Cancer Therapeutics"
    • Place of Presentation
      Moscone West Convention Center,サンフランシスコ
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Presentation] Phosphorylation of Bcl-xL by polo-like kinase 1 results in the inactivation of the anti-apoptotic activity during tubulin binder-induced apoptosis.2007

    • Author(s)
      Simizu, S.
    • Organizer
      AACR-NCI-EORTC International Conference "Molecular Targets and Cancer Therapeutics"Discovery, Biology, and Clinical Applications
    • Place of Presentation
      Moscone West Convention, Center, San Francisco, USA
    • Year and Date
      2007-10-23
    • Data Source
      KAKENHI-PROJECT-17016079
  • [Presentation] Phosphorylation of Bcl-xL by polo-1ike kinase I results inactivation of the anti-apoptotic activity during tubulin binder-induced apoptosis2007

    • Author(s)
      Simizu S., et. al.
    • Organizer
      AACR-NCI-EORTC International Conference "MolecularTargets and Cancer Therapeutics" Discovery, Biology, and Clinical Applications
    • Place of Presentation
      Moscone West Convention Center, San Francisco, USA
    • Year and Date
      2007-10-23
    • Data Source
      KAKENHI-PROJECT-17016079
  • [Presentation] RECK suppresses the expression of MMP-9 mRNA in human tumor cells2007

    • Author(s)
      高木聡, 清水史郎, 長田裕之
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Presentation] ヘパラナーゼに存在するシステイン残基の修飾とその役割解析2007

    • Author(s)
      清水史郎, 室井誠, Lai Ngit Shin, 高木聡, 堂前直, 長田裕之
    • Organizer
      第11回がん分子標的治療研究会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-07-05
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Presentation] Human heparanase: Activation and inhibition2007

    • Author(s)
      Simizu, S.
    • Organizer
      15th Proteoglycan Forum
    • Place of Presentation
      東京医科歯科大学
    • Year and Date
      2007-10-28
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Presentation] A novel chemical microarray platform for searching anticancer drugs2007

    • Author(s)
      清水史郎, 宮崎功, 奥村英夫, 叶直樹, 長田裕之
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Presentation] ヘパラナーゼに存在するシステイン残基の修飾とその役割解析2007

    • Author(s)
      清水史郎, 他
    • Organizer
      第11回 がん分子標的治療研究会総会
    • Place of Presentation
      大阪国際交流センター
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Presentation] Phosphorylation of Bcl-xL by polo-like kinase 1 results in the inactivation of the anti-apoptotic activity during tubulin binder-induced apoptosis2007

    • Author(s)
      Simizu, S., Tamura, Y., Kawatani, M, Watanabe, N., Osada, H.
    • Organizer
      AACR-NCI-EORTC International Conference "Molecular Targets and Cancer Therapeutics"
    • Place of Presentation
      アメリカ・サンフランシスコ
    • Year and Date
      2007-10-23
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Presentation] ヘパラナーゼに存在するシステイン残基の修飾とその役割解析2007

    • Author(s)
      清水 史郎, 他
    • Organizer
      第11回がん分子標的治療研究会総会
    • Place of Presentation
      大阪国際交流センター
    • Year and Date
      2007-07-05
    • Data Source
      KAKENHI-PROJECT-17016079
  • [Presentation] RECKによるMMP-9 mRNA減少機構の解明2007

    • Author(s)
      高木聡, 清水史郎, 長田裕之
    • Organizer
      第11回がん分子標的治療研究会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-07-05
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Presentation] PP2A特異的阻害剤ホスラクトマイシン類が有するHL60細胞の分化誘導活性2007

    • Author(s)
      照屋貴之, 清水史郎, 小林雄一, 長田裕之
    • Organizer
      日本農芸化学会2007年度大会
    • Place of Presentation
      東京
    • Year and Date
      2007-03-25
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Presentation] Human heparanase : Activation and inhibition2007

    • Author(s)
      Simizu, S.
    • Organizer
      15th Proteoglycan Forum
    • Place of Presentation
      東京
    • Year and Date
      2007-10-28
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Presentation] A novel chemical microarray platform for searching anticancer drugs2007

    • Author(s)
      清水 史郎 他
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-10-03
    • Data Source
      KAKENHI-PROJECT-17016079
  • [Presentation] 官能基非依存型低分子マイクロアレイとヒト培養細胞抽出物を用いた、タンパク質-低分子リガンド・スクリーニング系の構築2007

    • Author(s)
      宮崎功, 清水史郎, 奥村英夫, 叶直樹, 高橋良和, 野々村禎昭, 長田裕之
    • Organizer
      第2回日本ケミカルバイオロジー研究会年会
    • Place of Presentation
      京都
    • Year and Date
      2007-05-10
    • Data Source
      KAKENHI-PROJECT-18681035
  • [Presentation] N-linked glycan which attached Asn354 regulate secretion of Extracellular matrix protein 1

    • Author(s)
      Shiho Uematsu, Yuki Goto, Takehiro Suzuki, Yukiko Sasazawa, Naoshi Dohmae, Siro Simizu
    • Organizer
      15th International Biennial Congress of the Metastasis Research Society
    • Place of Presentation
      Heidelberg(Germany)
    • Year and Date
      2014-06-28 – 2014-07-01
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] Secretion of Extracellular matrix protein 1 is regulated by N-glycosylation

    • Author(s)
      植松 史帆、後藤 祐貴、笹澤 有紀子、清水 史郎
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] Pirin downregulates E-cadherin gene expression and contribute to EMT

    • Author(s)
      Kuniya Komai, Yuki Niwa, Yukiko Sasazawa, Siro Simizu
    • Organizer
      EORTC-NCI-AACR International Symposium on Molecular Targets and Cancer Therapeutics
    • Place of Presentation
      Barcelona(Spain)
    • Year and Date
      2014-11-18 – 2014-11-21
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] Human DPY19L3 is a C-mannosyltransferase for R-spondin1 and regulates R-spondin1 secretion

    • Author(s)
      丹羽 祐貴、清水 史郎
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] R-spondin1 functions are regulated by N-glycosylation

    • Author(s)
      Miyu Tsuchiya, Yuki Niwa, Siro Simizu
    • Organizer
      15th International Biennial Congress of the Metastasis Research Society
    • Place of Presentation
      Heidelberg(Germany)
    • Year and Date
      2014-06-28 – 2014-07-01
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] C-mannosylationによるR-spondin1の機能制御

    • Author(s)
      丹羽 祐貴、清水 史郎
    • Organizer
      第23回 日本がん転移学会学術集会・総会
    • Place of Presentation
      金沢市文化ホール(石川県・金沢市)
    • Year and Date
      2014-07-10 – 2014-07-11
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] Conophyllineの抗ハンチントン病作用

    • Author(s)
      佐藤 夏実、笹澤 有紀子、梅澤 一夫、清水 史郎
    • Organizer
      日本ケミカルバイオロジー学会 第9回年会
    • Place of Presentation
      大阪大学(大阪府・豊中市)
    • Year and Date
      2014-06-11 – 2014-06-13
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] Pirin regulates EMT by downregulating E-cadherin gene expression

    • Author(s)
      駒井 邦哉、丹羽 祐貴、笹澤 有紀子、清水 史郎
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] N-glycosylation regulates R-spondin1 functions

    • Author(s)
      土屋 みゆ、丹羽 祐貴、清水 史郎
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] 破骨細胞分化阻害剤の作用機構解析

    • Author(s)
      笹澤 有紀子、森下 佳典、杉野 公美、川谷 誠、長田 裕之、清水 史郎
    • Organizer
      日本ケミカルバイオロジー学会 第9回年会
    • Place of Presentation
      大阪大学(大阪府・豊中市)
    • Year and Date
      2014-06-11 – 2014-06-13
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] N型糖鎖修飾がHYAL1機能に与える影響

    • Author(s)
      後藤 祐貴、丹羽 祐貴、堂前 直、清水 史郎
    • Organizer
      日本がん分子標的治療学会 第18回学術集会
    • Place of Presentation
      仙台市情報・産業プラザ(宮城県・仙台市)
    • Year and Date
      2014-06-25 – 2014-06-27
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] クラビラクトン類縁体の合成

    • Author(s)
      茂木 拓馬、吉田 圭佑、高尾 賢一、宮嵜 奏、笹澤 有紀子、清水 史郎
    • Organizer
      日本化学会 第95春季年会
    • Place of Presentation
      日本大学(千葉県・船橋市)
    • Year and Date
      2015-03-26 – 2015-03-29
    • Data Source
      KAKENHI-PROJECT-24310167
  • 1.  KANOH Naoki (40317293)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 4 results
  • 2.  KONDOH Yasumitsu (80333342)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 3 results
  • 3.  OSADA Hiroyuki (80160836)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 13 results
  • 4.  SUDO Tatsuhiko (30260227)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  MUROI Makoto (30261168)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 6.  UEKI Masashi (90312264)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  UMEZAWA Kazuo (70114402)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  YOSHIMORI Tamotsu (60191649)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 9.  OHNO Hiroshi (50233226)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  SASAKI Takuya (40241278)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  IZUMI Tetsuro (00212952)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  FUKUDA Mitsunori (50311361)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  MAKINOUCHI Akitake (80087460)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  ISHIKAWA Yuichi (40348826)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  OZAKI Michitaka (80256510)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  SAITO Tsuyoshi (80609933)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  HAGA Sanae (60706505)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  USUI Takeo (60281648)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  KAKEYA Hideaki (00270596)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  SEKIYAMA Yasuyo (60342804)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  MACHIDA Kiyotaka (30332266)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  HAMAMOTO Ryuji (80321800)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  FUJITA Naonobu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 24.  RYOUHEI Katayama
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 25.  梅沢 一夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 31 results
  • 26.  千田 憲孝
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

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