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Yamashina Syunhei  山科 俊平

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YAMASHINA Shunhei  山科 俊平

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Researcher Number 30338412
Other IDs
Affiliation (Current) 2025: 順天堂大学, 医学部, 先任准教授
Affiliation (based on the past Project Information) *help 2021 – 2024: 順天堂大学, 医学部, 先任准教授
2007 – 2020: Juntendo University, 医学部, 准教授
2006: 順天堂大学, 医学部, 講師
Review Section/Research Field
Principal Investigator
Gastroenterology / Basic Section 53010:Gastroenterology-related
Except Principal Investigator
Gastroenterology / Basic Section 53010:Gastroenterology-related / Basic Section 59020:Sports sciences-related
Keywords
Principal Investigator
オートファジー / 肝疾患 / 肝再生 / アポトーシス / 微小核 / 癌 / カテプシンL / 癌治療 / p62 / 細胞競合 … More / 慢性肝炎 / 小胞体 / 細胞内代謝 / 肝脂肪化 / 脂肪性肝疾患 / ミトコンドリア / リソソーム / 核膜蛋白 / バイオマーカー / 血管新生 / TNFα / ROS / ネクローシス / 薬物性肝障害 / 炎症 / 細胞死 / 肝障害 / 肝線維化 / 肝炎症 / 化学療法 / C型肝炎 … More
Except Principal Investigator
オートファジー / メタボリックシンドローム / 自然免疫 / リソソーム / 非アルコール性脂肪肝炎(NASH) / NKT細胞 / 肝再生 / 核マトリクス / 核マトリクス蛋白 / 肝癌 / 腸内細菌叢 / 非アルコール性脂肪肝炎(NASH) / アミノ酸 / 免疫栄養 / カテプシン / 脂肪性肝疾患 / 細胞死 / 不溶性核蛋白 / 核内構造体 / 微小核 / 核内脂肪滴 / 乳酸オミクス解析 / 廃用性筋萎縮 / 悪液質筋萎縮 / 日本食 / サイトカインストーム / 腸肝相関 / COVID-19 / 代謝性障害性脂肪肝疾患(MAFLD) / 代謝障害性脂肪性肝疾患(MAFLD) / エンドトキシン・ショック / リポポリサッカライド(LPS) / サイトカイン・ストーム / 代謝障害関連脂肪性肝疾患(MAFLD) / エンドトキシン / MASH / 非アルコール性脂肪性肝疾患(NAFLD) / MASLD / アミノ酸代謝 / 代謝リプログラミング / 膵炎 / 膵癌 / バイオマーカー / 肝癌細胞 / 癌細胞 / 細胞極性 / エントーシス / RIG-I / インスリン / 糖代謝 / 耐糖能異常 / 腸内マイクロバイオーム / Kupffer細胞 / 肝発癌 / Th2サイトカイン / 非アルコール性脂肪肝炎 / 非アルコール性脂肪性肝疾患 / グリシン / 制御性T細胞 / 慢性肝炎 / チアゾリジン系誘導体 / アディポカイン / CD1d / NK細胞 / 肝線維化 / 非アルコール性脂肪肝炎(NASH) / 潰瘍性大腸炎 / ミトコンドリア / インスリン抵抗性 / エイコサペンタエン酸 / 酸化ストレス / 脂肪性肝炎 / 炎症 / 肝障害 Less
  • Research Projects

    (17 results)
  • Research Products

    (125 results)
  • Co-Researchers

    (12 People)
  •  Elucidation of the Pathophysiological Role of Micronucleus Induction and Stability in Liver DiseasesPrincipal Investigator

    • Principal Investigator
      山科 俊平
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Juntendo University
  •  Disuse and cachexia muscular atrophy: a lactylome analysis of mouse sheletal muscle.

    • Principal Investigator
      三浦 芳樹
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59020:Sports sciences-related
    • Research Institution
      Juntendo University
  •  The role of nuclear proteins and structures mediated by autophagy dysfunction in the pathogenesis of the fatty liver disease.

    • Principal Investigator
      渡辺 純夫
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Juntendo University
  •  Immunonutritional approach for innate immune dysregulation in metabolic dysfunction-associated fatty liver disease

    • Principal Investigator
      Ikejima Kenichi
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Juntendo University
  •  The relationship between autophagy-related nuclear matrix protein and epigenetic regulation of amino acid metabolism

    • Principal Investigator
      Watanabe Sumio
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Juntendo University
  •  Elucidation of the mechanism of cellular competition mediated by autophagy-related proteinsPrincipal Investigator

    • Principal Investigator
      YAMASHINA SHUNHEI
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Juntendo University
  •  Development of an early diagnosis method targeting nuclear matrix protein for autophagy-related digestive disorder disease

    • Principal Investigator
      WATANABE SUMIO
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Juntendo University
  •  Innate immune regulation in metabolic steatohepatitis and experimental therapeutics

    • Principal Investigator
      Ikejima Kenichi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Juntendo University
  •  Pathophysiological role of autophagic degradation of cellular organelles on liver diseasesPrincipal Investigator

    • Principal Investigator
      YAMASHINA SHUNHEI
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Juntendo University
  •  Loss of cell polarity and the role of autophagy in entosis

    • Principal Investigator
      INAMI YOSHIHIRO
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Juntendo University
  •  New therapeutic strategy to non-alcoholic liver disease targeting on autophagy

    • Principal Investigator
      WATANEBE Sumio
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Juntendo University
  •  Innate immune regulation of hepatic metabolism and immuno-nutritional approach for nonalcoholic fatty liver disease

    • Principal Investigator
      IKEJIMA Kenichi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Juntendo University
  •  Novel biomarker for evaluation of autophagic dysfunction in the liverPrincipal Investigator

    • Principal Investigator
      YAMASHINA SHUNHEI
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Juntendo University
  •  Central role of autophagy in the pathogenesis of gastrointestinal and hepatic diseases.

    • Principal Investigator
      WATANABE Sumio
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Juntendo University
  •  Role of innate immune system in the regulation of hepatic metabolism and pathogenesis of steatohepatitis

    • Principal Investigator
      IKEJIMA Kenichi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Juntendo University
  •  Role of autophagy in liver diseasesPrincipal Investigator

    • Principal Investigator
      YAMASHINA Shunhei
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Juntendo University
  •  慢性C型肝炎におけるオートファジーの生理学的意義の解明Principal Investigator

    • Principal Investigator
      山科 俊平
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Juntendo University

All 2023 2022 2021 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation Book

  • [Book] アラキドン酸側鎖含有合成脂質8A8によるエンドトキシン肝障害の抑制効果.アルコールと医学生物学2010

    • Author(s)
      池嶋健一, 朴南哲, 今一義, 青山友則, 山科俊平, 竹井謙之, 佐藤信紘, 渡辺純夫
    • Publisher
      東洋書店
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Book] 脂肪性肝炎における肝再生不全に対するpioglitazoneの改善効果.アルコールと医学生物学2009

    • Author(s)
      青山友則, 池嶋健一, 今一義, 山形寿文, 山科俊平, 佐藤信紘, 渡辺純夫
    • Publisher
      東洋書店
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Journal Article] Benefit of an action camera in endoscopy education for medical students under COVID-192023

    • Author(s)
      Uchiyama Akira、Yamashina Shunhei、Sato Toshifumi、Sakuma Satoshi、Tomiki Yuichi、Isayama Hiroyuki、Nagahara Akihito、Ikejima Kenichi
    • Journal Title

      BMC Medical Education

      Volume: 23 Issue: 1 Pages: 693-693

    • DOI

      10.1186/s12909-023-04702-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K07922
  • [Journal Article] Hepatic steatosis and skeletal muscle alterations during the COVID‐19 lockdown in a cohort of patients with chronic liver disease in Japan2023

    • Author(s)
      Uchiyama Akira、Kon Kazuyoshi、Sakuma Satoshi、Sato Toshifumi、Morinaga Maki、Fukada Hiroo、Yamagata Hisafumi、Yaginuma Reiko、Fukuhara Kyoko、Yamashina Shunhei、Nojiri Shuko、Ikejima Kenichi
    • Journal Title

      Hepatology Research

      Volume: 54 Issue: 3 Pages: 272-283

    • DOI

      10.1111/hepr.13981

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07922
  • [Journal Article] Gender-specific development of experimental autoimmune cholangitis induced by double-stranded RNA2022

    • Author(s)
      Someya Shunin、Uchiyama Akira、Arai Kumiko、Kon Kazuyoshi、Yamashina Shunhei、Watanabe Sumio、Ikejima Kenichi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 588 Pages: 90-96

    • DOI

      10.1016/j.bbrc.2021.12.011

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07922
  • [Journal Article] Autophagic dysfunction in the liver enhances the expression of insoluble nuclear proteins 14-3-3ζ and importin α42022

    • Author(s)
      Kousuke Izumi , Shunhei Yamashina , Tsutomu Fujimura, Sumio Watanabe , Kenichi Ikejima
    • Journal Title

      Life Sci.

      Volume: 298 Pages: 120491-120491

    • DOI

      10.1016/j.lfs.2022.120491

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K05880, KAKENHI-PROJECT-21K07922, KAKENHI-PROJECT-17K00874
  • [Journal Article] Carbohydrate-deficient transferrin is a sensitive marker of alcohol consumption in fatty liver disease2022

    • Author(s)
      Morinaga Maki、Kon Kazuyoshi、Uchiyama Akira、Fukada Hiroo、Fukuhara Kyoko、Yaginuma Reiko、Nakadera Eisuke、Yamashina Shunhei、Ikejima Kenichi
    • Journal Title

      Hepatology International

      Volume: 16 Issue: 2 Pages: 348-358

    • DOI

      10.1007/s12072-022-10298-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07922
  • [Journal Article] Cathepsin L-deficiency enhances liver regeneration after partial hepatectomy2019

    • Author(s)
      Sato Toshifumi、Yamashina Shunhei、Izumi Kosuke、Ueno Takashi、Koike Masato、Ikejima Kenichi、Peters Christoph、Watanabe Sumio
    • Journal Title

      Life Sciences

      Volume: 221 Pages: 293-300

    • DOI

      10.1016/j.lfs.2019.02.040

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-18K08016, KAKENHI-PROJECT-16H05293
  • [Journal Article] Formation of p62-positive inclusion body is associated with macrophage polarization in non-alcoholic fatty liver disease.2018

    • Author(s)
      Fukushima H, Yamashina S, Arakawa A, Taniguchi G, Aoyama T, Uchiyama A, Kon K, Ikejima K, Watanabe S.
    • Journal Title

      Hepatol Res.

      Volume: 48 Issue: 9 Pages: 757-767

    • DOI

      10.1111/hepr.13071

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K09023
  • [Journal Article] Sodium 4-phenylbutyric acid prevents murine acetaminophen hepatotoxicity by minimizing endoplasmic reticulum stress.2017

    • Author(s)
      Kusama H, Kon K, Ikejima K, Arai K, Aoyama T, Uchiyama A, Yamashina S, Watanabe S.
    • Journal Title

      J Gastroenterol.

      Volume: 52 Issue: 5 Pages: 611-622

    • DOI

      10.1007/s00535-016-1256-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09023
  • [Journal Article] Spleen-derived lipocalin-2 in the portal vein regulates Kupffer cells activation and attenuates the development of liver fibrosis in mice.2017

    • Author(s)
      Aoyama T, Kuwahara-Arai K, Uchiyama A, Kon K, Okubo H, Yamashina S, Ikejima K, Kokubu S, Miyazaki A, Watanabe S.
    • Journal Title

      Lab Invest.

      Volume: 97 Issue: 8 Pages: 890-902

    • DOI

      10.1038/labinvest.2017.44

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K09023, KAKENHI-PROJECT-15K19350
  • [Journal Article] A Customized Online Nutrition Guidance System Is Effective for Treating Patients with Nonalcoholic Fatty Liver Disease by Supporting Continuity of Diet Therapy at Home: A Pilot Study2017

    • Author(s)
      Aoyama T, Takada H, Uchiyama A, Kon K, Yamashina S, Ikejima K, Ban H, Watanabe S.
    • Journal Title

      Intern. Med.

      Volume: 56 Issue: 13 Pages: 1651-1656

    • DOI

      10.2169/internalmedicine.56.8187

    • NAID

      130006858091

    • ISSN
      0918-2918, 1349-7235
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09023
  • [Journal Article] Glycine prevents metabolic steatohepatitis in diabetic KK-Ay mice through modulation of hepatic innate immunity.2016

    • Author(s)
      Takashima S, Ikejima K, Arai K, Yokokawa J, Kon K, Yamashina S, Watanabe S.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol

      Volume: 311 Issue: 6 Pages: G1105-G1113

    • DOI

      10.1152/ajpgi.00465.2015

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09023
  • [Journal Article] Inhibition of mTOR improves the impairment of acidification in autophagic vesicles caused by hepatic steatosis.2016

    • Author(s)
      Nakadera E, Yamashina S, Izumi K, Inami Y, Sato T, Fukushima H, Kon K, Ikejima K, Ueno T, Watanabe S.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 469(4) Issue: 4 Pages: 1104-10

    • DOI

      10.1016/j.bbrc.2015.12.010

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K09023
  • [Journal Article] L-carnitine prevents metabolic steatohepatitis in obese diabetic KK-Ay mice.2016

    • Author(s)
      Kon K, Ikejima K, Morinaga M, Kusama H, Arai K, Aoyama T, Uchiyama A, Yamashina S, Watanabe S
    • Journal Title

      Hepatology Research

      Volume: Apr Issue: 3 Pages: 44-54

    • DOI

      10.1111/hepr.12720

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09022, KAKENHI-PROJECT-15K09023
  • [Journal Article] Sodium 4-phenylbutyrate prevents murine dietary steatohepatitis caused by <i>trans</i>-fatty acid plus fructose2015

    • Author(s)
      Morinaga M, Kon K, Saito H, Arai K, Kusama H, Uchiyama A, Yamashina S, Ikejima K, Watanabe S.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 57 Issue: 3 Pages: 183-191

    • DOI

      10.3164/jcbn.15-75

    • NAID

      130005106455

    • ISSN
      0912-0009, 1880-5086
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09022, KAKENHI-PROJECT-15K09023
  • [Journal Article] Abnormality of autophagic function and cathepsin expression in the liver from patients with non-alcoholic fatty liver disease.2014

    • Author(s)
      Yuka Fukuo, Shunhei Yamashina, Hiroshi Sonoue, Atsushi Arakawa, Eisuke Nakadera, Tomonori Aoyama, Akira Uchiyama, Kazuyoshi Kon, Kenichi Ikejima, Sumio Watanabe
    • Journal Title

      Hepatology Research

      Volume: 未定 Issue: 9 Pages: 1026-1036

    • DOI

      10.1111/hepr.12282

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23590989, KAKENHI-PROJECT-24390191, KAKENHI-PROJECT-24590995, KAKENHI-PROJECT-24590996
  • [Journal Article] Innate immune responses involving natural killer and natural killer T cells promote liver regeneration after partial hepatectomy in mice.2013

    • Author(s)
      Hosoya S.Ikejima K.Takeda K.Arai K.Ishikawa S.Yamagata H.Aoyama T.Kon K.Yamashina S.Kon K.Watanabe S.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol.

      Volume: 304 Issue: 3 Pages: G293-G299

    • DOI

      10.1152/ajpgi.00083.2012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590995, KAKENHI-PROJECT-24590996
  • [Journal Article] Supression of autophagy sensitizes Kupffer cells to endotoxin.2012

    • Author(s)
      Fukada H, Yamashina S, Izumi K, Komatsu M, Tanaka K, Ikejima K, Watanabe S.
    • Journal Title

      Hepatol. Res.

      Volume: 42 Issue: 11 Pages: 1112-1118

    • DOI

      10.1111/j.1872-034x.2012.01024.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590996
  • [Journal Article] Hepatic steatosis inhibits autophagic proteolysis via impairment aut ophagosomal acidification and cathepsin expression2011

    • Author(s)
      Inami Y, Yamashina S, Izumi K, Ueno T Tanida I, Ikejima K, Watanabe S
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 412 Pages: 618-625

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Journal Article] Izunai K, Ueno T Tanida I, Watanabe S.Hepatic steatosis inhibits autophagic proteolysis via impairment of autophagosomal acidification and cathepsin expression2011

    • Author(s)
      Inami Y, Yamashina S, Ikejima K, et al.(7人中6番目)
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 412 Pages: 618-625

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Journal Article] Loss of autophagy promotes murine acetaminophen hepatotoxicity2011

    • Author(s)
      Igusa Y, Yamashina S, et al
    • Journal Title

      Journal of Gastroenterology

      Volume: 47 Issue: 4 Pages: 433-443

    • DOI

      10.1007/s00535-011-0500-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390234, KAKENHI-PROJECT-24590996
  • [Journal Article] Hepatic steatosis inhibits autophagic proteolysis via impairment of autophagosomal acidification and cathepsin expression2011

    • Author(s)
      Inami Y, Yamashina S, Izumi K, Ueno T, Tanida I, Ikejima K, Watanabe S
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 412(4) Pages: 618-618

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390234
  • [Journal Article] Hepatic steatosis inhibits autophagic proteolysis via impairment of autophagosomal acidification and cathepsin expression2011

    • Author(s)
      Inami Y, Yamashina S, et al
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 412 Issue: 4 Pages: 618-25

    • DOI

      10.1016/j.bbrc.2011.08.012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390234, KAKENHI-PROJECT-21570155
  • [Journal Article] Loss of autophagy promotes murine ace taminophen hepatotoxicity2011

    • Author(s)
      Igusa Y, Yamashina S, Izumi K, Inami Y, Fukada H, Komatsu M, Tanaka K, Ikejima K, Watanabe S
    • Journal Title

      J Gastroenterol

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Journal Article] Loss of autophagy promotes murine acetaminophen hepatotoxicity2011

    • Author(s)
      Igusa Y, Yamashina S, Izumi K, Inami Y, Fukada H, Komatsu M, Tanaka K, Ikejima K
    • Journal Title

      Watanabe S J Gastroenterol

    • NAID

      10030650144

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390234
  • [Journal Article] Inhibition of hepatitis C virus replication by chloroquine targeting virus-associated autophagy.2010

    • Author(s)
      Mizui T, Yamashina S, Ikejima K, et al., (12人中7番目)
    • Journal Title

      J Gastroenterol

      Volume: 45 Pages: 195-203

    • NAID

      10027214573

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Journal Article] Inhibition of hepatitis C virus replication by chloroquine targeting virus-associated autophagy2010

    • Author(s)
      Mizui T, Yamashina S, Tanida I, Takei Y, Ueno T, Sakamoto N, Ikejima K, Kitamura T, Enomoto N, Sakai T, Kominami E, Watanabe S
    • Journal Title

      J Gastroenterol

      Volume: 45(2) Pages: 195-203

    • NAID

      10027214573

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Journal Article] Role of mitochondria in liver pathophysiology2009

    • Author(s)
      Yamashina S, Sato N, Kon K, Ikejima K, Watanabe S
    • Journal Title

      Drug Discovery Today : Disease Mechanisms

      Volume: 6(1-4)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Journal Article] 特集肝病態生理研究のあゆみ16.肝星細胞活性化に対するPTENの抑制効果2009

    • Author(s)
      高島基樹, 池嶋健一, 今一義, 山科俊平, 鈴木聡子, 渡辺純夫
    • Journal Title

      薬理と治療(JPT)

      Volume: 37

    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] Diagnosis of Perihepatitis and Fitz-Hugh-Curtis Syndrome by Laparoscopy: An Unusual Condition for Right Hypochondriac Pain and Liver Injury?2023

    • Author(s)
      Shunsuke Ikejima, Akira Uchiyama, Maki Morinaga, Hiroo Fukada, Hisafumi Yamagata, Reiko Yaginuma, Kyoko Fukuhara, Kazuyoshi Kon, Shunhei Yamashina, Kenichi Ikejima.
    • Organizer
      Asian Pacific Association for the Study of the Liver (APASL) 2023 Taipei
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07922
  • [Presentation] The trends of acute hepatitis A and hepatitis E during the COVID-19 pandemic in Japan.2023

    • Author(s)
      Hiroo Fukada, Kazuyoshi Kon, Satoshi Sakuma, Toshifumi Sato, Maki Morinaga, Toshifumi Yamagata, Akira Uchiyama, Reiko Yaginuma, Kyoko Fukuhara, Shunhei Yamashina, Kenichi Ikejima.
    • Organizer
      Asian Pacific Association for the Study of the Liver (APASL) 2023 Taipei
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07922
  • [Presentation] ペマフィブラートによるオートファジー誘導を介した脂肪酸添加後ミトコンドリア障害と細胞障害の抑制効果2023

    • Author(s)
      山科俊平、今一義、池嶋健一
    • Organizer
      第109回日本消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-20K08296
  • [Presentation] A selective PPARα modulator pemafibrate reduced palmitic acid-induced lipotoxicity via induction of autophagy.2023

    • Author(s)
      Shunhei Yamashina, Satoshi Sakuma, Toshifumi Sato, Hiroo Fukada, HisafumiYamagata, Akira Uchiyama, Reiko Yaginuma, Kyoko Fukuhara, Kazuyoshi Kon, Kenichi Ikejima
    • Organizer
      The Asian Pacific Association for the Study of the Liver annual meeting 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08296
  • [Presentation] A selective PPARα modulator pemafibrate reduced palmitic acid-induced lipotoxicity via induction of autophagy.2023

    • Author(s)
      Shunhei Yamashina, Satoshi Sakuma, Toshifumi Sato, Hiroo Fukada, Hisafumi Yamagata, Akira Uchiyama, Reiko Yaginuma, Kyoko Fukuhara, Kazuyoshi Kon, Kenichi Ikejima.
    • Organizer
      Asian Pacific Association for the Study of the Liver (APASL) 2023 Taipei
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07922
  • [Presentation] Type I and type II natural killar T cells are involved in the development of steatohepatitis in elder mice.2022

    • Author(s)
      Kazuyoshi Kon, Eisuke Nakadera, Kumiko Arai, Akira Uchiyama, Hiroo Fukada, Toshifumi Sato, Reiko Yaginuma, Kyoko Okumura, Shunhei Yamashina, Kenichi Ikejima.
    • Organizer
      Digestive Disease Week 2022
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07922
  • [Presentation] Perihepatitis and Fitz-Hugh-Curtis syndrome: an unusual condition for upper abdominal pain and liver injury?2022

    • Author(s)
      Akira Uchiyama, Kazuyoshi Kon, Hiroo Fukada, Maki Morinaga, Reiko Yaginuma, Kyoko Fukuhara, Shunhei Yamashina, Kenichi Ikejima.
    • Organizer
      American Association for the Study of Liver Disease (AASLD) The Liver Meeting 2022
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07922
  • [Presentation] Glycine prevents steatohepatitis-related carcinogenesis in hepatocyte-specific phosphatase and tensin homolog-deficient mice.2022

    • Author(s)
      Kazuyoshi Kon, Kumiko Arai, Akira Uchiyama, Hiroo Fukada, Toshifumi Sato, Maki Morinaga, Kyoko Fukuhara, Reiko Yaginuma, Shunhei Yamashina, Kenichi Ikejima
    • Organizer
      Asian Pacific Association for the Study of the Liver (APASL) Oncology 2022 Takamatsu
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07922
  • [Presentation] Glycine supplementation inhibits steatohepatitis-related liver carcinogenesis in hepaticyte-specific PTEN deficient mice.2022

    • Author(s)
      Kazuyoshi Kon, Kumiko Arai, Akira Uchiyama, Reiko Yaginuma, Toshifumi Sato, Shunhei Yamashina, Kenichi Ikejima
    • Organizer
      American Association for the Study of Liver Disease (AASLD) The Liver Meeting 2022
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07922
  • [Presentation] Amino acid prevents tumorigenesis via ameliorating steatohepatitis in hepatocyte-specific phosphatase and tensin homolog knockout2021

    • Author(s)
      K Kon, K Arai, A Uchiyama, H Fukada, E Nakadera, M Morinaga, K Fukuhara, R Yaginuma, S Yamashina, K Ikejima.
    • Organizer
      American Association for the Study of Liver Disease (AASLD) The Liver Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07922
  • [Presentation] Glycine ameliorates steatohepatitis via reduction of oxidative stress in hepatocyte-specific PTEN-deficient mice.2021

    • Author(s)
      K Kon, A Uchiyama, H Fukada, E Nakadera, R Yaginuma, K Fukuhara, S Yamashina, K Ikejima.
    • Organizer
      The Asian Pacific Association for the Study of the Liver (APASL) Single Topic Conference. Molecular and Cell Biology of the Liver: Recent Evolution to Clinical Application, Osaka
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07922
  • [Presentation] Type I and type II NKT cells additively exacerbates steatohepatitis caused by high-fat and high-cholesterol diet in aged mice.2021

    • Author(s)
      E Nakadera, K Kon, K Arai, H Fukada, A Uchiyama, S Yamashina, K Ikejima.
    • Organizer
      American Association for the Study of Liver Disease (AASLD) The Liver Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07922
  • [Presentation] Hyperactivation of immune response following modulation of small intestinal microbiome causes exacerbation of alcoholic liver injury in female KK-Ay mice.2021

    • Author(s)
      K Kon, A Uchiyama, H Fukada, E Nakadera, R Yaginuma, K Fukuhara, S Yamashina, K Ikejima.
    • Organizer
      20th Congress of the International Society for Biomedical Research on Alcoholism
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07922
  • [Presentation] Accumulation of autophagy-specific substrate p62/SQSTM1 are associated with the formation of multinucleated cells in liver cancer2021

    • Author(s)
      S Yamashina, E Nakadera, H Fukada, A Uchiyama, R Yaginuma, K Fukuhra, K Kon, K Ikejima.
    • Organizer
      American Association for the Study of Liver Disease (AASLD) The Liver Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07922
  • [Presentation] The formation of P62-positive inclusion body is associated with macrophage polarization in non-alcohoic fatty liver disease.2017

    • Author(s)
      Fukushima H, Yamashina S, Arakawa A, Taniguchi G, Aoyama T, Uchiyama A, Kon K, Ikejima K, Watanabe S.
    • Organizer
      Digestive Disease Week
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09023
  • [Presentation] Female hormone enhances hepatic innate and autoimmune responses against double-stranded RNA.2017

    • Author(s)
      Uchiyama A, Ikejima K, Someya S, Arai K, Aoyama T, Kon K, Yamashina S, Watanabe S.
    • Organizer
      the Liver Meeting 2017 (AASLD)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09023
  • [Presentation] L-carnitine changes hepatic lipid composition and prevents lipotoxicity in hign-fat diet-fed KK-Ay mice.2017

    • Author(s)
      Kon K, Ikejima K, Uchiyama A, Arai K, Aoyama T, Yamashina S, Watanabe S.
    • Organizer
      Digestive Disease Week
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09023
  • [Presentation] Aging exacerbates high-fat diet-induced steatohepatitis through blunting of lipid metabolic response in mice.2017

    • Author(s)
      Ishizuka K, Kon K, Ikejima K, Suzuki M, Arai K, Uchiyama A, Aoyama T, Yamashina S, Watanabe S.
    • Organizer
      the Liver Meeting 2017 (AASLD)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09023
  • [Presentation] Glycine minimizes murine autoimmune cholangitisand pancreatitis caused by double-stranded RNA through modulation of innate immune response.2017

    • Author(s)
      Uchiyama A, Ikejima K, Kon K, Arai K, Fukuhara K, Aoyama T, Yamashina S, Watanabe S 演題名 GLYCINE MINIMIZES MURINE AUTOIMMUNE CHOLANGITIS AND PANCREATITIS CAUSED BY DOUBLE-STRANDED RNA THROUGH MODULATION OF INNATE IMMUNE RESPONSES 学会名
    • Organizer
      Digestive Disease Week
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09023
  • [Presentation] Identification of Nuclear Matrix Protein Alternations associated with Autophagic Dysfunction in the Liver2016

    • Author(s)
      山科俊平
    • Organizer
      Digestive Disease Week 2016
    • Place of Presentation
      San Diego Convention Center in San Diego
    • Year and Date
      2016-05-21
    • Data Source
      KAKENHI-PROJECT-26461020
  • [Presentation] Efficacy of denosumab on progression of osteoporosis in autoimmune liver diseases2016

    • Author(s)
      Ikejima K, Yaginuma R, Kon K, Aoyama T, Uchiyama A, Yamashina S, Watanabe S
    • Organizer
      The Liver Meeting 2016 (AASLD)
    • Place of Presentation
      Boston, MA, USA
    • Year and Date
      2016-11-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09023
  • [Presentation] 自己免疫性胆管病変マウスモデルにおける性差の解析2016

    • Author(s)
      染谷秀忍,池嶋健一,内山明,鈴木麻衣子,青山友則,今一義,山科俊平,渡辺純夫
    • Organizer
      JDDW2016
    • Place of Presentation
      神戸
    • Year and Date
      2016-11-03
    • Data Source
      KAKENHI-PROJECT-15K09023
  • [Presentation] Real-world efficacy of antiviral treatment using a combination of daclatasvir and asnaprevir in Japanese patients of chronic hepatitis C2016

    • Author(s)
      Ikejima K, Fukuhara K, Aoyama T, Uchiyama A, Kon K, Yamashina S, Watanabe S
    • Organizer
      HCV2016
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2016-10-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09023
  • [Presentation] Metabolic disease and NASH2016

    • Author(s)
      Ikejima K, Kon K, Yamashina S, Watanabe S
    • Organizer
      25th Conference of the Asian Pacific Association for the Study of the Liver
    • Place of Presentation
      Tokyo
    • Year and Date
      2016-02-23
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09023
  • [Presentation] Dietary glycine improves impaired glucose tolerance by modulating polarization of Kupffer cells in diabetic KK-Ay mice.2015

    • Author(s)
      Ikejima K, Arai K, Kon K, Uchiyama A, Yamashina S, Watanabe S
    • Organizer
      Digestive Disease Week
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2015-05-17
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09023
  • [Presentation] Contribution of regulatory T cells in pathogenesis of nonalcoholic steatohepatitis in mice2015

    • Author(s)
      Ikejima K, Yokokawa J, Arai K, Uchiyama A, Kon K, Yamashina S, Watanabe S
    • Organizer
      18th International Symposium on the Cells of Hepatic Sinusoid
    • Place of Presentation
      Asilomar, CA, USA
    • Year and Date
      2015-11-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09023
  • [Presentation] 肝脂肪化によるmTOR活性化を介したリソソーム酸性化障害とオートファジー機能抑制2015

    • Author(s)
      中寺英介、山科俊平、渡辺純夫
    • Organizer
      第101回消化器病学会総会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2015-04-24
    • Data Source
      KAKENHI-PROJECT-24390191
  • [Presentation] Ursolic acid ameliorates murine cholangitis induced by double-stranded RNA2014

    • Author(s)
      Ikejima K, Arai K, Uchiyama A, Kon K, Yamashina S, Watanabe S.
    • Organizer
      European Association for the Study of the Liver
    • Place of Presentation
      London
    • Year and Date
      2014-04-11
    • Data Source
      KAKENHI-PROJECT-24590996
  • [Presentation] Dietary supplementation of glycine ameliorates diabetic steatohepatitis in KK-Ay mice through immune-metabolic regulation2014

    • Author(s)
      Ikejima K, Takashima S, Arai K, Kon K, Yamashina S, Watanabe S
    • Organizer
      Digestive Disease Week
    • Place of Presentation
      Chicago
    • Year and Date
      2014-05-03
    • Data Source
      KAKENHI-PROJECT-24590996
  • [Presentation] Glycine prevents maturity-onset obesity and metabolic steatohepatitis in diabetic KK-Ay mice through modulation of hepatic innate immunity2013

    • Author(s)
      Ikejima K, Takashima S, Arai K, Kon K, Yamashina S, Watanabe S
    • Organizer
      Digestive Diesase Week
    • Place of Presentation
      Orlando, FL, USA
    • Data Source
      KAKENHI-PROJECT-24590996
  • [Presentation] Long term efficacy and safety of low-dose pioglitazone treatment for nonalcoholic fatty liver disease with insulin resistance2013

    • Author(s)
      Ikejima K, Fukuhara K, Yaginuma R, Kon K, Yamashina S, Suzuki S, Watanabe S
    • Organizer
      Asian Pacific Association for the Study of the Liver (APASL) Liver Week 2013
    • Place of Presentation
      Singapore
    • Data Source
      KAKENHI-PROJECT-24590996
  • [Presentation] 非アルコール性脂肪性肝疾患患者におけるオートファジー機能障害とカテプシン発現異常2013

    • Author(s)
      福生有華, 山科 俊平, 泉 光輔, 園上 浩司, 荒川 敦, 青山 友則, 内山 明, 今 一義, 鈴木 聡子, 池嶋 健一, 渡辺 純夫
    • Organizer
      第49回日本肝臓学会総会
    • Place of Presentation
      京王プラザホテル
    • Data Source
      KAKENHI-PROJECT-24390191
  • [Presentation] 非アルコール性脂肪性肝疾患患者におけるオートファジー機能障害とカテプシン発現異常2013

    • Author(s)
      福生有華,山科俊平,泉光輔,園上浩司,荒川敦,青山友則,内山明,今一義,鈴木聡子,池嶋健一,渡辺純夫
    • Organizer
      肝臓(0451-4203)54巻Suppl.1 PageA146
    • Data Source
      KAKENHI-PROJECT-23590989
  • [Presentation] Hepatic regulatory T Cells contribute to the development of dietary steatohepatitis in mice.2013

    • Author(s)
      Yokokawa J, Ikejima K, Arai K, Kon K, Yamashina S, Watanabe S
    • Organizer
      American Association for the Study of Liver Diseases
    • Place of Presentation
      Washington DC, USA
    • Data Source
      KAKENHI-PROJECT-24590996
  • [Presentation] Ursolic acid minimizes cholestatic liver injury in common bile duct-ligated rats2013

    • Author(s)
      Ikejima K, Arai K, Kon K, Yamashina S, Watanabe S
    • Organizer
      European Association for the Study of the Liver
    • Place of Presentation
      Amsterdam
    • Data Source
      KAKENHI-PROJECT-24590996
  • [Presentation] NAFLD患者における肝カテプシンL発現とオートファジー機能の評価福生有華2012

    • Author(s)
      山科俊平,泉光輔,稲見義宏,山形寿文,今一義,鈴木聡子,池嶋健一,渡辺純夫
    • Organizer
      肝臓(0451-4203)53巻Suppl.3 PageA929
    • Data Source
      KAKENHI-PROJECT-23590989
  • [Presentation] 肝細胞内脂肪滴蓄積とオートファジー機能障害2011

    • Author(s)
      山科俊平、稲見義宏、今一義、池嶋健一、渡辺純夫
    • Organizer
      第47回日本肝臓学会総会ワークショップ
    • Place of Presentation
      東京都ホテルグランパシフィック
    • Year and Date
      2011-06-02
    • Data Source
      KAKENHI-PROJECT-21390234
  • [Presentation] Innate immune responses involving NK and NKT cells promote liver regeneration after partial hepatectomy2011

    • Author(s)
      Hosoya S, Ikejima K, Arai K, Kon K, Yamashina S, Takeda K, Watanabe S
    • Organizer
      Poster Session(Poster of Distinction), The Liver Meeting 2011(Annual Meeting of American Association for Study of Liver Diseases)
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2011-11-07
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] Loss of parkin impairs liver regeneration2011

    • Author(s)
      Fukada H, Yamashina S, Izumi K, Nakadera E, Fukuo Y, Uchiyama A, Kon K, Ikejima K, Watanabe S
    • Organizer
      Poster Session, The Liver Meeting 2011(Annual Meeting of American Association for Study of Liver Diseases)
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2011-11-06
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] 肝細胞内脂肪滴蓄積とオートファジー機能障害.ワークショップ2 NASH-我が国の実態と発生機序の解明に向けて2011

    • Author(s)
      山科俊平, 稲見義宏, 今一義, 池嶋健一, 渡辺純夫
    • Organizer
      第47回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-02
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] Ursolic acid ameliorates hepatic fibrogenesis through induction of apoptosis in hepa Ses sion : Fibrogenesis Experimental2011

    • Author(s)
      Ikejima K, WFukuhara K, Hosoya S, Yamashina S, Watanabe S
    • Organizer
      The International Liver Congress 2011 : 46th Annual Meeting of the European Association for the Study of the Liver(EASL)
    • Place of Presentation
      Berlin, Germany
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] Differential role of natural killer T cell subsets in xenobiotics-induced hepatic inflammation and fibrogenesis2011

    • Author(s)
      Ikejima K, Ishikawa S, Hosoya S, Yamagata H, Arai K, Kon K, Yamashina S, Watanabe S
    • Organizer
      Poster Session(Poster of Distinction), Digestive Disease Week
    • Place of Presentation
      Chicago
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] アセトアミノフェン投与後の肝細胞死誘導に対する関与について.アセトアミノフェン投与後の肝細胞死誘導に対する関与について2011

    • Author(s)
      井草祐樹, 山科俊平, 今一義, 池嶋健一, 渡辺純夫
    • Organizer
      アセトアミノフェン投与後の肝細胞死誘導に対する関与について
    • Place of Presentation
      東京
    • Year and Date
      2011-06-02
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] Hepatic NKT cells are progressively depleted in steatohepatitis with tumorigenesis caused by hepatocyte-specific PTEN deficiency2011

    • Author(s)
      Miyaji T, Ikejima K, Hosoya S, Arai K, Kon K, Yamashina S, Watanabe S
    • Organizer
      Poster Session, The Liver Meeting 2011(Annual Meeting of Am Ass ociation for Study of Liver Diseases)
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2011-11-07
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] Mice depleting natural killer T cells are more susceptible to dietary-induced steatohepatitis, Selected Oral Presentation 102011

    • Author(s)
      Ikejima K, Yamagata H, Arai K, Ishikawa S, Hosoya S, Kon K, Yamashina S, Suzuki S, Takeda K, Watanabe S
    • Organizer
      18th International Symposium on Cells of the Hepatic Sinusoid(Biannual Meeting of International Society for Hepatic Sinusoidal Research)
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2011-09-22
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] Imaired liver regeneration after partial hepatectomy in mice depleting NK and NKT cells2011

    • Author(s)
      Hosoya S, Ikejima K, Arai K, Aoyama T, Kon K, Ishikawa S, Yamagata H, Yamashina S, Suzuki S, Takeda K, Watanabe S
    • Organizer
      Poster Session, 18th International Symposium on Cells of the Hepa Sin usoid(Biannual Meeting of International Society for Hepatic Sinusoidal Research)
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2011-09-22
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] 脂肪肝における低酸素暴露後のZone 3優位の酸化ストレスと肝細胞アポトーシス2011

    • Author(s)
      今一義, 池嶋健一, 谷口源太郎, 内山明, 福原京子, 細谷聡子, 山科俊平, 渡辺純夫
    • Organizer
      第47回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-03
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] ジエチルニトロソアミン投与後肝障害におけるオートファジーの関与について2010

    • Author(s)
      米合古麗阿不都雪克, 山科俊平, 深田浩大, 井草祐樹, 今一義, 池嶋健一, 渡辺純夫
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形
    • Year and Date
      2010-05-28
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] High-carbohydrate diet containing trans-fatty acid induces severe steatohepatitis via the enhancement of endoplasmic reticulum stress in KK-Ay mice2010

    • Author(s)
      Saito H, Kon K, Ishikawa S, Hosoya S, Arai K, Takashima M, Yamashina S, Ikejima K, Watanabe S
    • Organizer
      Poster Session, The 45th annual meeting of the European Association for the Study of the Liver
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2010-04-16
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] 脂肪性肝炎の病態形成におけるトランス脂肪酸の影響と酸化ストレスの役割.ワークショップ7,肝病態形成におおける酸化ストレスの意義2010

    • Author(s)
      今一義, 池嶋健一, 細谷聡子, 斉藤紘昭, 石川幸子, 柳沼礼子, 山科俊平, 渡辺純夫
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      新潟
    • Year and Date
      2010-05-28
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] 肥満モデルにおけるオートファジーを介した蛋白分解機能の変化2010

    • Author(s)
      稲見義宏、山科俊平、渡辺純夫
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      ホテルメトロポリタン山形
    • Year and Date
      2010-05-27
    • Data Source
      KAKENHI-PROJECT-21390234
  • [Presentation] アセトアミノフェン投与後肝障害におけるオートファジーの役割の検討2010

    • Author(s)
      井草祐樹, 山科俊平, 今一義, 池嶋健一, 渡辺純夫
    • Organizer
      第14回日本肝臓学会大会(JDDW 2010)
    • Place of Presentation
      横浜
    • Year and Date
      2010-10-13
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] 虚血再還流における肝細胞死とオートファジーの関係について2010

    • Author(s)
      山科俊平
    • Organizer
      Cytoprotection 研究会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-05
    • Data Source
      KAKENHI-PROJECT-20590797
  • [Presentation] 肝細胞内脂肪滴によるオートファジー機能障害と酸化ストレス2010

    • Author(s)
      稲見義宏、山科俊平、渡辺純夫
    • Organizer
      第18回日本消化器関連学会週間
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2010-10-14
    • Data Source
      KAKENHI-PROJECT-21390234
  • [Presentation] 肝細胞内脂肪滴によるオートファジー機能障害と酸化ストレス.シンポジウム7 : NAFLD/NASHの最近の知見2010

    • Author(s)
      稲見義宏, 山科俊平, 渡辺純夫
    • Organizer
      第14回日本肝臓学会大会(JDDW2010)
    • Place of Presentation
      横浜
    • Year and Date
      2010-10-14
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] Trans-fatty acid induces apoptosis of hepatocytes by enhancement of oxidative stress in steatotic liver of KK-Ay mice2010

    • Author(s)
      Kon K, Ikejima K, Saito H, Ishikawa S, Hosoya S, Arai K, Okumura K, Yamashina S, Watanabe S
    • Organizer
      Poster Session, The Liver Meeting 2010(Annual Meeting of American Association for Study of Liver Diseases)
    • Place of Presentation
      Boston, MA, USA
    • Year and Date
      2010-11-01
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] アセトアミノフェン投与後肝障害におけるオートファジーの役割の検討2010

    • Author(s)
      井草祐樹、山科俊平、今一義、池嶋健一、渡辺純夫
    • Organizer
      第18回日本消化器関連学会週間
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2010-10-13
    • Data Source
      KAKENHI-PROJECT-20590797
  • [Presentation] Loss of autophagy enhances the sensitization of Kupffer cells to endo toxin2010

    • Author(s)
      Hiroo Fukada, Shunhei Yamashina, Kousuke Izumi, Yoshihiro Inami, Kazuyoshi Kon, Kenichi Ikejima, Sumio Watanabe
    • Organizer
      The American association for the study of liver diseases 61th annual meeting and postgraduate course# 1971
    • Place of Presentation
      米国ボストンHynes convention center
    • Year and Date
      2010-11-03
    • Data Source
      KAKENHI-PROJECT-21390234
  • [Presentation] 肥満モデルにおけるオートファジーを介した蛋白分解機能の変化2010

    • Author(s)
      稲見義宏、山科俊平、渡辺純夫
    • Organizer
      第46回日本肝臓学会総会パネルディスカッション
    • Place of Presentation
      山形県山形テルサホール
    • Year and Date
      2010-05-28
    • Data Source
      KAKENHI-PROJECT-21390234
  • [Presentation] Ursolic acid ameliorates dietary steatohepatitis in obese diabetic KK-Ay mice2010

    • Author(s)
      Ikejima K, Piao N, Yamagata H, Kon K, Yamashina S, Watanabe S
    • Organizer
      AASLD Poster Session, Digestive Disease Week(DDW)
    • Place of Presentation
      New Orleans, LA, USA
    • Year and Date
      2010-05-02
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] Innate immunity and NAFLD/NASH. Session 4 : Immunity and cytokine responses in NASH2010

    • Author(s)
      Ikejima K, Yamagata H, Hosoya S, Ishikawa S, Aoyama T, Kon K, Yamashina S, Suzuki S, Watanabe S
    • Organizer
      The 9th Japan Society of Hepatology(JSH) Single Topic Conference NASH-2010
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2010-11-18
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] Loss of autophagy enhances the sensitization of Kupffer cells to endotoxin2010

    • Author(s)
      Fukada H, Yamashina S, Izumi K, Inami Y, Kon K, Ikejima K, Watanabe S
    • Organizer
      Poster Session Meeting 2010(Annual Meeting of American Association for Study of Liver Diseases)
    • Place of Presentation
      Boston, MA, USA
    • Year and Date
      2010-11-03
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] Loss of autophagy enhances acetaminophen-induced liver injury2010

    • Author(s)
      Igusa Y, Yamashina S, Izumi K, Fukada H, Mikirai A, Inami Y, Kon K, Ikejima K, Watanabe S
    • Organizer
      AASLD Poster Session, Digestive Disease Week(DDW)
    • Place of Presentation
      New Orleans, LA, USA
    • Year and Date
      2010-05-02
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] Synthetic triglyceride containing an arachidonic acid branch(8A8) minimizes endotoxin-induced liver injury2010

    • Author(s)
      Ikejima K, Piao N, Kon K, Aoyama T, Yamashina S, Takei Y, Sato N, Watanabe S
    • Organizer
      Poster Session, 2010 International Society for Biomedical Research on Alcoholism(ISBRA) World Congress
    • Place of Presentation
      Paris, France
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] Hepatic steatosis suppresses autophagic proteolysis. Poster Session2010

    • Author(s)
      Yamashina S, Inami Y Ikejima K, Watanabe S
    • Organizer
      2010 International Society for Bi Alc oholism(ISBRA) World Congress
    • Place of Presentation
      Paris, France
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] Depletion of natural killer T cells increases the susceptibility to dietary-induced steatohepatitis in mice2010

    • Author(s)
      Ikejima K, Yamagata H, Arai K, Ishikawa S, Hosoya S, Kon K, Yamashina S, Takeda K, Watanabe S
    • Organizer
      Poster Session, The Liver Meeting 2010(Annual Meeting of American Association for Study of Liver Diseases)
    • Place of Presentation
      Boston, MA, USA
    • Year and Date
      2010-11-01
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] Hepatic NKT and NK cells regulate liver reg hep atectomy in mice2010

    • Author(s)
      Hosoya S, Ikejima K, Aoyama T, Ishikawa S, Yamagata H, Kon K, Yamashina S, Takeda K, Watanabe S
    • Organizer
      Poster Session, The Liver Meeting 2010(Annual Meeting of American Association for Study of Liver Diseases)
    • Place of Presentation
      Boston, MA, USA
    • Year and Date
      2010-11-03
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] He viral response to peg an d ribavirin therapy in Japanese patients with chronic hepatitis C. Poster Session2009

    • Author(s)
      Yaginuma R, Ikejima K, Aoyama T, Yamagata H, Ishikawa S, KonK, Yamashina S, Suzuki S, Watanabe S
    • Organizer
      The 44th annual meeting of the European Association for the Study of the Liver
    • Place of Presentation
      Copenhagen, Denmark
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] Ezetimibe prevents metabolic syndrome-related steatohepatitis exacerbated by trans-fatty acid in KK-Ay mice. Poster Session2009

    • Author(s)
      Kon K, Ikejima K, Aoyama T, Ishikawa S, Hosoya S, Arai K, Yamashina S, Watanabe S
    • Organizer
      The Liver Meeting 2009(Annual Meeting of American Association for Study of Liver Diseases)
    • Place of Presentation
      Boston, USA
    • Year and Date
      2009-11-03
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] HBs抗原陰性・HCV抗体陰性の肝細胞癌における臨床的特徴と腫瘍マーカー測定の重要性2009

    • Author(s)
      今一義, 池嶋健一, 青山友則, 山形寿文, 柳沼礼子, 石川幸子, 高島基樹, 山科俊平, 鈴木聡子, 渡辺純夫
    • Organizer
      第95回日本消化器病学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2009-05-09
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] Obese diabetic KK-Ay mice are resistant to NKT cell-mediated liver injury induced by a-galactosylceramide2009

    • Author(s)
      Ikejima K, Yamagata H, Takeda K, Aoyama T, Kon K, Yamashina S, Suzuki S, Watanabe S
    • Organizer
      Poster S The 44th annual meeting of the European Association for the Study of the Liver
    • Place of Presentation
      Copenhagen, Denmark
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] Pioglitazone improves abnormal expression of hepatic NKT cells in obese and diabetic KK-Ay mice2009

    • Author(s)
      Ikejima K, Yamagata H, Takeda K, Kon K, Aoyama T, Yamashina S, Watanabe S
    • Organizer
      Poster session Conference on NAFLD/NASH and related metabolic disease
    • Place of Presentation
      Bologna, Italy
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] メタボリックシンドロームモデルKK-Ayマウスにおける肝内NKT細胞分画異常に対するピオグリタゾンの影響2009

    • Author(s)
      山形寿文, 池嶋健一, 青山友則, 今一義, 山科俊平, 渡辺純夫
    • Organizer
      第45回日本肝臓学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2009-06-05
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] Pioglitazone restores expression and function of hepatic NKT cells in obese and diabetic KK-Ay mice2009

    • Author(s)
      Yamagata H, Ikejima K, Takeda K, Aoyama T, Kon K, Yamashina S, Watanabe S
    • Organizer
      Poster Session, The 44 meeting of the European Association for the Study of the Liver
    • Place of Presentation
      Copenhagen, Denmark
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] 脂肪性肝炎形成における肝細胞内貯蔵鉄の役割-マウス初代培養肝細胞を用いた検討-ワークショップ1, NASH・NAFLDの礎2009

    • Author(s)
      今一義, 池嶋健一, 青山友則, 山形寿文, 内山明, 高島基樹, 石川幸子, 柳沼礼子, 山科俊平, 鈴木聡子, 渡辺純夫
    • Organizer
      第45回日本肝臓学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2009-06-04
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] NAFLD患者の低用量ピオグリタゾン療法におけるMRI肝脂肪測定の有用性2009

    • Author(s)
      柳沼礼子, 池嶋健一, 福原京子, 青山友則, 今一義, 山科俊平, 鈴木聡子, 渡辺純夫
    • Organizer
      第45回日本肝臓学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2009-06-05
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] Lipid accumulation inhibits induction of autophagy in the mouse liver2009

    • Author(s)
      Inami Y, Yamashina S, Izumi K, Fukada H, Kon K, Ikejima K, Watanabe S
    • Organizer
      Poster Session, The Liver Meetin Am erican Association for Study of Liver Diseases
    • Place of Presentation
      Boston, USA
    • Year and Date
      2009-11-03
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] C型肝炎ウイルス複製におけるニコチンの作用2009

    • Author(s)
      山科俊平, 高島基樹, 青山友則, 柳沼礼子, 今一義, 鈴木聡子, 池嶋健一, 佐藤信紘, 渡辺純夫
    • Organizer
      ポスターセッション,第13回日本肝臓学会大会(JDDW 2009)
    • Year and Date
      2009-10-14
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] Increased susceptibility to ethanol-induced liver injury in genetically diabetic KK-Ay mice2009

    • Author(s)
      Ikejima K, Kon K, Yamagata H, Aoyama T, Yamashina S, Suzuki S, Watanabe S
    • Organizer
      AASLD Poster Session, D Di sease Week(DDW)
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2009-06-02
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] Lipid accumulation inhibits induction of autophagy in the mouse liver2009

    • Author(s)
      Yoshihiro Inami, Shunhei Yamashina, Kousuke Izumi, Hiroo Fukada, Kazuyoshi Kon, Kenichi Ikejima, Sumio Watanabe
    • Organizer
      The American association for the study of liver diseases 60th annual meeting and postgraduate course# 1875
    • Place of Presentation
      日米国ボストンHynes convention center
    • Year and Date
      2009-11-03
    • Data Source
      KAKENHI-PROJECT-21390234
  • [Presentation] C型慢性肝炎のペグインターフェロンα-2b・リバビリン併用療法のガイドライン準拠率と治療奏効性の関連2009

    • Author(s)
      柳沼礼子, 池嶋健一, 青山友則, 山形寿文, 石川幸子, 今一義, 山科俊平, 鈴木聡子, 渡辺純夫
    • Organizer
      ポスターセッション,第13回日本肝臓学会大会(JDDW 2009)
    • Year and Date
      2009-11-14
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] Pioglitazone prevents apoptosis of hepatic NKT cells in obese and diabetic KK-Ay mice2009

    • Author(s)
      Yamagata H, Ikejima K, Takeda K, Kon K, Aoyama T, Yamashina S, Watanabe S
    • Organizer
      Poster Session,(Annual Meeting of American Association for Study of Liver Diseases)
    • Place of Presentation
      Boston, USA
    • Year and Date
      2009-11-03
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] Efficacy of low-dose pioglitazone for the treatment of NAFLD patients in Japan2008

    • Author(s)
      Yaginuma R, Ikejima K, Kon K, Okumura K, Yamashina S, Suzuki S, Watanabe S
    • Organizer
      Poster Session, The Liver Meeting 2009 on(Annual Meeting of American Association for Study of Liver Diseases)
    • Place of Presentation
      Boston, USA
    • Year and Date
      2008-11-01
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] 肝部分切除後の肝再生におけるオートファジーの役割2008

    • Author(s)
      山科俊平
    • Organizer
      第50回日本消化器病学会大会
    • Year and Date
      2008-10-01
    • Data Source
      KAKENHI-PROJECT-20590797
  • [Presentation] オートファジー蛋白分解糸を標的とした新たなC型肝炎治療戦略2008

    • Author(s)
      山科俊平
    • Organizer
      第44回日本肝臓学会総会
    • Place of Presentation
      愛媛県県民文化会館、愛媛、日本
    • Year and Date
      2008-06-05
    • Data Source
      KAKENHI-PROJECT-18790475
  • [Presentation] 肝部分切除後の肝再生におけるオートファジーの役割2008

    • Author(s)
      山科俊平
    • Organizer
      第12回日本肝臓学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-01
    • Data Source
      KAKENHI-PROJECT-20590797
  • [Presentation] 肝部分切除後の肝再生におけるオートファジーの役割2008

    • Author(s)
      山科俊平
    • Organizer
      浜名湖シンポジウム
    • Year and Date
      2008-12-25
    • Data Source
      KAKENHI-PROJECT-20590797
  • [Presentation] オートファジーを標的とした新たなHCV治療戦略-クロロキンによる抗ウイルス効果について2007

    • Author(s)
      水井 智和・山科俊平・渡辺純夫
    • Organizer
      第43回日本肝臓学会総会
    • Place of Presentation
      ホテルグランパシフィックメリディアン、東京、日本
    • Year and Date
      2007-06-01
    • Data Source
      KAKENHI-PROJECT-18790475
  • [Presentation] Chloroquine inhibits HCV replication synerglcally with interferon-alpha.2007

    • Author(s)
      Tomokazu, Mizui・Shunhei, Yamashina・Sumio, Watanabe
    • Organizer
      Asian Pacific Digestive Week 2007
    • Place of Presentation
      Kobe Convention Complex,神戸、日本
    • Year and Date
      2007-10-17
    • Data Source
      KAKENHI-PROJECT-18790475
  • [Presentation] Anti-malatial drug chloroquine suppresses the replication of HCV replication via PKR-independent mechanisms.2007

    • Author(s)
      Tomokazu, Mizui・Shunhei, Yamashina・Sumio, Watanabe
    • Organizer
      The 58th Annual Meeting of the American Association for the Study of Liver diseases
    • Place of Presentation
      Hynes Convention Center, Boston, USA
    • Year and Date
      2007-11-03
    • Data Source
      KAKENHI-PROJECT-18790475
  • [Presentation] Pathophysiological role of adipocytokines in the digestive system.

    • Author(s)
      Ikejima K, Kon K, Yamashina S, Watanabe S.
    • Organizer
      The 3rd Asian-Pacific Topic Conference
    • Place of Presentation
      Tokyo, Japan
    • Invited
    • Data Source
      KAKENHI-PROJECT-24590996
  • [Presentation] Role of NK and NKT cells in the pathogenesis and carcinogenesis in steatohepatitis.

    • Author(s)
      Ikejima, K, Miyaji T, Hosoya S, Arai K, Kon K, Yamashina S, Watanabe S.
    • Organizer
      16th Congress of International Society for Biomedical Research on Alcoholism
    • Place of Presentation
      Sapporo, Japan
    • Data Source
      KAKENHI-PROJECT-24590996
  • [Presentation] Hepatic steatosis suppresses mitochondrial autophagy

    • Author(s)
      Yamashina S, Inami Y, Uchiyama A, Kon K, Ikejima K, Watanabe S
    • Organizer
      Poster Session 1 : Animal Models and Pathogenesis-1, 6th International Symposium on Alcoholic Liver and Pancreatic Diseases Cirrohosis
    • Place of Presentation
      Fukuoka, Japan
    • Data Source
      KAKENHI-PROJECT-21590859
  • [Presentation] Induction of apoptosis in hepatic stellate cells as a treatment strategy for hepatic fibrosis.

    • Author(s)
      Ikejima K, Wang X, Arai K, Kon K, Yamashina S, Watanabe S.
    • Organizer
      16th Congress of International Society for Biomedical Research on Alcoholism.
    • Place of Presentation
      Sapporo, Japan
    • Data Source
      KAKENHI-PROJECT-24590996
  • [Presentation] 脂肪性肝炎の共通病態基盤としての肝内自然免疫系の関与

    • Author(s)
      池嶋健一,今一義,山科俊平,渡辺純夫
    • Organizer
      第12回日本抗加齢医学会総会
    • Place of Presentation
      横浜
    • Invited
    • Data Source
      KAKENHI-PROJECT-24590996
  • 1.  IKEJIMA Kenichi (20317382)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 103 results
  • 2.  KON Yoshikazu (30398672)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 87 results
  • 3.  WATANABE Sumio (20138225)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 9 results
  • 4.  UENO Takashi (10053373)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 1 results
  • 5.  TAKEDA Kazuyoshi (80272821)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 9 results
  • 6.  INAMI YOSHIHIRO (70445500)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  SUEMIZU Hiroshi (40332209)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  三浦 芳樹 (90279240)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  TAKASHIMA Motoki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  FUJIMURA Tsutomu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  内山 明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  小池 正人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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