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Takeuchi Hideyuki  竹内 英之

… Alternative Names

TAKEUCHI Hideyuki  竹内 英之

竹内 英之  タケウチ ヒデユキ

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Researcher Number 30362213
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-5912-7581
Affiliation (Current) 2025: 国際医療福祉大学, 医学部, 教授
2025: 横浜市立大学, 医学研究科, 客員教授
Affiliation (based on the past Project Information) *help 2023 – 2024: 国際医療福祉大学, 医学部, 教授
2023: 横浜市立大学, 医学研究科, 客員教授
2017 – 2022: 横浜市立大学, 医学部, 准教授
2016: 横浜市立大学, 附属病院, 准教授
2012 – 2015: 名古屋大学, 環境医学研究所, 助教
2005 – 2006: 名古屋大学, 環境医学研究所, 助手
Review Section/Research Field
Principal Investigator
Basic Section 52020:Neurology-related / Neurology / Biological Sciences
Except Principal Investigator
Basic Section 52020:Neurology-related / Basic Section 51030:Pathophysiologic neuroscience-related / Medium-sized Section 52:General internal medicine and related fields / Neurology
Keywords
Principal Investigator
神経変性疾患 / ミクログリア / 単球系細胞 / 全身炎症 / マクロファージ / 脳神経疾患 / ニューロン / 神経変性 / IL-19 / 神経炎症 … More / アストロサイト / 制御性T細胞 / ミッドカイン / T細胞 / コンディショナルノックアウトマウス / ノックアウトマウス / 前頭側頭葉型認知症 / 筋萎縮性側索硬化症 / TDP-43 / 毒性転換 / neuritic beading / 神経細胞機能不全 / 興奮性神経毒性 / サイトカイン / グルタミン酸 … More
Except Principal Investigator
ALS / ミクログリア / microglia / 多発性硬化症 / Nogo / LOTUS / 脊髄小脳変性症 / 神経変性疾患 / 脱髄疾患 / コネキシン / 伝搬 / オリゴマー / シヌクレイン / 脱髄 / 多系統萎縮症 / RNA結合タンパク質 / 非膜オルガネラ / FTLD / 病態解析 / リピート病 / RAN translation / RFC1 / FISH / 病理学的解析 / RNA foci / CANVAS / アミロイド / アミロイドβ / タウ / RIPK1 / amyloid-beta / tau / CACNA1G / 光遺伝学 / 疾患修飾療法 / カルシウムチャネル / neuroinflammation / multiple sclerosis / マイクログリア / 軸索変性 / 神経炎症 / Nogo受容体 / SALS / DDX17 / DDX5 / Dead box RNA helicase / 孤発性ALS / DEAD box RNA helicase / DEAD box protein / TDP-43 / PIR-B / コンディショナルノックアウト / UBQLN2 / ノックアウトマウス / 筋萎縮性側索硬化症 / マウスモデル / 脊髄小脳失調症 / calcium channel / mouse model / spinocerebellar ataxia / アストロサイト Less
  • Research Projects

    (18 results)
  • Research Products

    (105 results)
  • Co-Researchers

    (37 People)
  •  全身炎症に伴う単球系細胞の異常分化遷移による神経変性疾患の病態進展の機序解明Principal Investigator

    • Principal Investigator
      竹内 英之
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      International University of Health and Welfare
  •  Elucidation of glia inflammation mechanisms common to degeneration and demyelination by novel pathogenic microglia

    • Principal Investigator
      吉良 潤一
    • Project Period (FY)
      2023 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      International University of Health and Welfare
  •  Analysis of pathological dynamics of membrane-less organelles in SALS

    • Principal Investigator
      多田 美紀子
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 51030:Pathophysiologic neuroscience-related
    • Research Institution
      Yokohama City University
  •  Development of disease-modifying therapy for spinocerebellar ataxia type 42 and elucidation of pathophysiological basis using optogenetic methods

    • Principal Investigator
      DOI Hiroshi
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 51030:Pathophysiologic neuroscience-related
    • Research Institution
      Yokohama City University
  •  Elucidation of amyloid-tau association and development of new therapeutic methods based on analysis of microglia RIPK1

    • Principal Investigator
      KATSUMOTO Atsuko
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Yokohama City University
  •  Establishment of a pathophysiological analysis model for novel intronic repeat disease CANVAS

    • Principal Investigator
      Tanaka Fumiaki
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Yokohama City University
  •  Elucidation of the mechanism of neurodegenerative disease progression by systemic inflammationPrincipal Investigator

    • Principal Investigator
      Takeuchi Hideyuki
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Yokohama City University
  •  Development of innovative treatment for multiple sclerosis based on control of neurodegeneration and inflammation by applying function of LOTUS

    • Principal Investigator
      TAKAHASHI Keita
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 51030:Pathophysiologic neuroscience-related
    • Research Institution
      Yokohama City University
  •  DEAD box RNA helicases are involved in sporadic ALS pathology

    • Principal Investigator
      TADA Mikiko
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 51030:Pathophysiologic neuroscience-related
    • Research Institution
      Yokohama City University
  •  Elucidation of pathophysiology and development of treatment for spinocerebellar ataxia using a novel mouse model

    • Principal Investigator
      DOI Hiroshi
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Yokohama City University
  •  Analysis of UBQLN2 based on loss of function model

    • Principal Investigator
      TANAKA Kenichi
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Yokohama City University
  •  Development of novel therapeutic strategy against neurodegenerative diseases by modulation of monocyte-lineage cellPrincipal Investigator

    • Principal Investigator
      TAKEUCHI Hideyuki
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Yokohama City University
  •  Development of ALS therapy targeting LOTUS, a functional molecule for neuronal regeneration

    • Principal Investigator
      TANAKA Fumiaki
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Yokohama City University
  •  Role of T cell dysregulation in neurodegenerative diseasesPrincipal Investigator

    • Principal Investigator
      TAKEUCHI Hideyuki
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Yokohama City University
      Nagoya University
  •  Elucidating pathomechanism of ALS through the abnormality in astrocytes

    • Principal Investigator
      YAMANAKA Koji
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Nagoya University
  •  ミクログリアの毒性転換の制御による神経変性疾患の新規治療法開発Principal Investigator

    • Principal Investigator
      竹内 英之
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Nagoya University
  •  Elucidation of disease mechanism of ALS/FTD using TDP-43vconditional knockout micePrincipal Investigator

    • Principal Investigator
      TAKEUCHI Hideyuki
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Nagoya University
  •  神経変性に伴うニューロン・ミクログリア間の応答因子の探索Principal Investigator

    • Principal Investigator
      竹内 英之
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Neurology
    • Research Institution
      Nagoya University

All 2024 2023 2022 2021 2020 2019 2018 2017 2015 2014 2013 2012 2011 2006 2005 Other

All Journal Article Presentation Book Patent

  • [Book] Midkine: From Embryogenesis to Pathogenesis and Therapy2012

    • Author(s)
      Takeuchi H
    • Total Pages
      335
    • Publisher
      Springer
    • Data Source
      KAKENHI-PUBLICLY-24111520
  • [Journal Article] Reduced likelihood of the Poggendorff illusion in cerebellar strokes: a clinical and neuroimaging study2023

    • Author(s)
      Higashiyama Yuichi、Kuroki Miho、Kudo Yosuke、Hamada Tomoya、Morihara Keisuke、Saito Asami、Miyaji Yosuke、Kimura Katsuo、Joki Hideto、Kishida Hitaru、Doi Hiroshi、Ueda Naohisa、Takeuchi Hideyuki、Johkura Ken、Tanaka Fumiaki
    • Journal Title

      Brain Communications

      Volume: 5 Issue: 2

    • DOI

      10.1093/braincomms/fcad053

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K15714, KAKENHI-PROJECT-21K07298
  • [Journal Article] Autoimmune disorders mimicking neurodegenerative diseases2023

    • Author(s)
      Takeuchi Hideyuki
    • Journal Title

      Clinical and Experimental Neuroimmunology

      Volume: 14 Issue: 4 Pages: 158-158

    • DOI

      10.1111/cen3.12770

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07465
  • [Journal Article] RNA Foci in Two bi‐Allelic RFC1 Expansion Carriers2023

    • Author(s)
      Wada Taishi、Doi Hiroshi, et al.
    • Journal Title

      Annals of Neurology

      Volume: 95 Issue: 3 Pages: 607-613

    • DOI

      10.1002/ana.26848

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K07298, KAKENHI-PROJECT-21K07440, KAKENHI-PROJECT-22K15041, KAKENHI-ORGANIZER-21H05158, KAKENHI-PLANNED-21H05159, KAKENHI-PROJECT-21H02405, KAKENHI-PROJECT-23K27520
  • [Journal Article] Lateral olfactory tract usher substance (LOTUS), an endogenous Nogo receptor antagonist, ameliorates disease progression in amyotrophic lateral sclerosis model mice2023

    • Author(s)
      Ikeda Takuya、Takahashi Keita、Higashi Minatsu、Komiya Hiroyasu、Asano Tetsuya、Ogasawara Akihiro、Kubota Shun、Hashiguchi Shunta、Kunii Misako、Tanaka Kenichi、Tada Mikiko、Doi Hiroshi、Takeuchi Hideyuki、Takei Kohtaro、Tanaka Fumiaki
    • Journal Title

      Cell Death Discovery

      Volume: 9 Issue: 1 Pages: 454-454

    • DOI

      10.1038/s41420-023-01758-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K07298, KAKENHI-PROJECT-21K07465
  • [Journal Article] Anti-inflammatory effects of siponimod on astrocytes2022

    • Author(s)
      Akihiro Ogasawara, ・・Hiroshi Doi, Fumiaki Tanaka
    • Journal Title

      Neuroscience Research

      Volume: 184 Pages: 38-46

    • DOI

      10.1016/j.neures.2022.08.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07298, KAKENHI-PROJECT-21K07465
  • [Journal Article] Inhibition of Crmp1 phosphorylation at Ser522 ameliorates motor function and neuronal pathology in amyotrophic lateral sclerosis model mice2022

    • Author(s)
      Asano Tetsuya、Nakamura Haruko、Kawamoto Yuko、Tada Mikiko、Kimura Yayoi、Takano Hiroshi、Yao Ryoji、Saito Hiroya、Ikeda Takuya、Komiya Hiroyasu、Kubota Shun、Hashiguchi Shunta、Takahashi Keita、Kunii Misako、Tanaka Kenichi、Goshima Yoshio、Nakamura Fumio、Takeuchi Hideyuki、Doi Hiroshi、Tanaka Fumiaki
    • Journal Title

      eneuro

      Volume: - Issue: 3 Pages: 0133-22

    • DOI

      10.1523/eneuro.0133-22.2022

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K07419, KAKENHI-PROJECT-21K07298, KAKENHI-PROJECT-21K07465, KAKENHI-PROJECT-18K15457
  • [Journal Article] Phosphorylated CRMP1, axon guidance protein, is a component of spheroids and is involved in axonal pathology in amyotrophic lateral sclerosis2022

    • Author(s)
      Yuko, Kawamoto・・・Hiroshi Doi, et al.
    • Journal Title

      Frontiers in Neurology

      Volume: 13 Pages: 994676-994676

    • DOI

      10.3389/fneur.2022.994676

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K07298, KAKENHI-PROJECT-21K07465, KAKENHI-PROJECT-18K15457
  • [Journal Article] Ablation of interleukin-19 improves motor function in a mouse model of amyotrophic lateral sclerosis2021

    • Author(s)
      Komiya Hiroyasu、Takeuchi Hideyuki、Ogawa Yuki、Suzuki Kosuke、Ogasawara Akihiro、Takahashi Keita、Azuma Yasu-Taka、Doi Hiroshi、Tanaka Fumiaki
    • Journal Title

      Molecular Brain

      Volume: 14 Issue: 1 Pages: 74-74

    • DOI

      10.1186/s13041-021-00785-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07531, KAKENHI-PROJECT-18K07532, KAKENHI-PROJECT-21K07298, KAKENHI-PROJECT-21K07465
  • [Journal Article] Interleukin-19 Abrogates Experimental Autoimmune Encephalomyelitis by Attenuating Antigen-Presenting Cell Activation2021

    • Author(s)
      Horiuchi Hiroshi、Parajuli Bijay、Komiya Hiroyasu、Ogawa Yuki、Jin Shijie、Takahashi Keita、Azuma Yasu-Taka、Tanaka Fumiaki、Suzumura Akio、Takeuchi Hideyuki
    • Journal Title

      Frontiers in Immunology

      Volume: 12 Pages: 615465-615465

    • DOI

      10.3389/fimmu.2021.615898

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K21510, KAKENHI-PROJECT-18K07531, KAKENHI-PROJECT-18K14825, KAKENHI-PROJECT-21K07465
  • [Journal Article] Therapeutic efficacy of heparin and direct factor Xa inhibitors in cancer-associated cryptogenic ischemic stroke with venous thromboembolism2021

    • Author(s)
      Yamaura Genpei、Ito Takeshi、Miyaji Yosuke、Ueda Naohisa、Nakae Yoshiharu、Momoo Takayuki、Nakano Tatsu、Johmura Yuji、Higashiyama Yuichi、Joki Hideto、Doi Hiroshi、Takeuchi Hideyuki、Takahashi Tatsuya、Koyano Shigeru、Yamaguchi Shigeki、Yokoyama Mutsumi、Tanaka Fumiaki
    • Journal Title

      Thrombosis Research

      Volume: 206 Pages: 99-103

    • DOI

      10.1016/j.thromres.2021.08.016

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07298
  • [Journal Article] SGTA associates with intracellular aggregates in neurodegenerative diseases2021

    • Author(s)
      Kubota Shun、Doi Hiroshi、Koyano Shigeru、Tanaka Kenichi、Komiya Hiroyasu、Katsumoto Atsuko、Ikeda Shingo、Hashiguchi Shunta、Nakamura Haruko、Fukai Ryoko、Takahashi Keita、Kunii Misako、Tada Mikiko、Takeuchi Hideyuki、Tanaka Fumiaki
    • Journal Title

      Molecular Brain

      Volume: 14 Issue: 1 Pages: 59-59

    • DOI

      10.1186/s13041-021-00770-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K16581, KAKENHI-PROJECT-21K07465
  • [Journal Article] Long-read Sequencing Identifies the Pathogenic Nucleotide Repeat Expansion in RFC1 in a Japanese Case of CANVAS2020

    • Author(s)
      Haruko Nakamura, Hiroshi Doi, Satomi Mitsuhashi, Satoko Miyatake, Kazutaka Katoh, Martin C Frith, Tetsuya Asano, Yosuke Kudo, Takuya Ikeda, Shun Kubota, Misako Kunii, Yu Kitazawa, Mikiko Tada, Mitsuo Okamoto, Hideto Joki, Hideyuki Takeuchi, Naomichi Matsumoto, Fumiaki Tanaka
    • Journal Title

      Journal of Human Genetics

      Volume: 65 Issue: 5 Pages: 475-480

    • DOI

      10.1038/s10038-020-0733-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07977, KAKENHI-PROJECT-19K17014, KAKENHI-PROJECT-17K10080, KAKENHI-PROJECT-20K06767, KAKENHI-PROJECT-20K07907, KAKENHI-PROJECT-18K07503
  • [Journal Article] CCR2 is localized in microglia and neurons, as well as infiltrating monocytes, in the lumbar spinal cord of ALS mice.2020

    • Author(s)
      Komiya H, Takeuchi H (責任著者), Ogawa Y, Hatooka Y, Takahashi K, Katsumoto A, Kubota S, Nakamura H, Kunii M, Tada M, Doi H, Tanaka F
    • Journal Title

      Molecular Brain

      Volume: 13 Issue: 1 Pages: 64-64

    • DOI

      10.1186/s13041-020-00607-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07531, KAKENHI-PROJECT-19K17014, KAKENHI-PROJECT-18K07503, KAKENHI-PROJECT-18K07532
  • [Journal Article] Reply to "GGC Repeat Expansion of NOTCH2NLC is Rare in European Leukoencephalopathy"2020

    • Author(s)
      Doi H, Okubo M, Fukai R, Fujita A, Mitsuhashi S, Takahashi K, Kunii M, Tada M, Fukuda H, Mizuguchi T, Miyatake S, Miyake N, Sone J, Sobue G, Takeuchi H, Matsumoto N and Tanaka F
    • Journal Title

      Ann Neurol

      Volume: 88 Issue: 3 Pages: 642-643

    • DOI

      10.1002/ana.25819

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K08164, KAKENHI-PROJECT-20K16581, KAKENHI-PROJECT-18K07503
  • [Journal Article] Tonsillectomy Improved Therapeutic Response in Anti-SRP Myopathy With Chronic Tonsillitis2020

    • Author(s)
      Ikeda Takuya、Takeuchi Hideyuki、Takahashi Keita、Nakamura Haruko、Kunii Misako、Katsumoto Atsuko、Tada Mikiko、Higashiyama Yuichi、Hibiya Takashi、Suzuki Shigeaki、Nishino Ichizo、Koyano Shigeru、Doi Hiroshi、Tanaka Fumiaki
    • Journal Title

      Frontiers in Immunology

      Volume: 11 Pages: 595480-595480

    • DOI

      10.3389/fimmu.2020.595480

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07503
  • [Journal Article] De novo CACNA1G variants in developmental delay and early-onset epileptic encephalopathies2020

    • Author(s)
      Misako Kunii, Hiroshi Doi, Shunta Hashiguchi, Toyojiro Matsuishi, Yasunari Sakai, Mizue Iai, Masaki Okubo, Haruko Nakamura, Keita Takahashi, Atsuko Katsumoto, Mikiko Tada, Hideyuki Takeuchi, Taro Ishikawa, Noriko Miyake, Hirotomo Saitsu, Naomichi Matsumoto, Fumiaki Tanaka
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 416 Pages: 117047-117047

    • DOI

      10.1016/j.jns.2020.117047

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06529, KAKENHI-PROJECT-19K08281, KAKENHI-PROJECT-20H03641, KAKENHI-PROJECT-18K07503, KAKENHI-PROJECT-19K17014
  • [Journal Article] Adult-onset vocal cord paralysis in slow-channel congenital myasthenic syndrome2019

    • Author(s)
      Nakamura Haruko、Komiya Hiroyasu、Uematsu Eri、Nakae Yoshiharu、Tanaka Kenichi、Kunii Misako、Tada Mikiko、Joki Hideto、Koyano Shigeru、Matsumoto Naomichi、Doi Hiroshi、Takeuchi Hideyuki、Tanaka Fumiaki
    • Journal Title

      Neurology: Clinical Practice

      Volume: 9 Issue: 5

    • DOI

      10.1212/cpj.0000000000000599

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07503, KAKENHI-PROJECT-18K07504, KAKENHI-PROJECT-19K17014, KAKENHI-PROJECT-17H01539
  • [Journal Article] Proteomic analysis of exosome-enriched fractions derived from cerebrospinal fluid of amyotrophic lateral sclerosis patients2019

    • Author(s)
      Hayashi Noriko、Doi Hiroshi、Kurata Yoichi、Kagawa Hiroyuki、Atobe Yoshitoshi、Funakoshi Kengo、Tada Mikiko、Katsumoto Atsuko、Tanaka Kenichi、Kunii Misako、Nakamura Haruko、Takahashi Keita、Takeuchi Hideyuki、Koyano Shigeru、Kimura Yayoi、Hirano Hisashi、Tanaka Fumiaki
    • Journal Title

      Neuroscience Research

      Volume: in press Pages: 30487-0

    • DOI

      10.1016/j.neures.2019.10.010

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07503, KAKENHI-PROJECT-18K07504, KAKENHI-PROJECT-19K17014, KAKENHI-PROJECT-18K15460, KAKENHI-PROJECT-19H03774
  • [Journal Article] Non-traumatic Acute Epidural Hematoma in Multiple Sclerosis Treated With Fingolimod2019

    • Author(s)
      Fukai Ryoko、Takahashi Keita、Abe Hiroyuki、Higashiyama Yuichi、Doi Hiroshi、Takeuchi Hideyuki、Tanaka Fumiaki
    • Journal Title

      Frontiers in Neurology

      Volume: 10 Pages: 763-763

    • DOI

      10.3389/fneur.2019.00763

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07503, KAKENHI-PROJECT-18K15459
  • [Journal Article] Tau Pathology in Chronic Traumatic Encephalopathy and Alzheimer's Disease: Similarities and Differences.2019

    • Author(s)
      Katsumoto A, Takeuchi H (責任著者), Tanaka F
    • Journal Title

      Frontiers in Neurology

      Volume: 10 Pages: 980-980

    • DOI

      10.3389/fneur.2019.00980

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07531, KAKENHI-PROJECT-18K15460
  • [Journal Article] Genetic analysis of adult leukoencephalopathy patients using a custom-designed gene panel2018

    • Author(s)
      Kunii M.、Doi H.、Ishii Y.、Ohba C.、Tanaka K.、Tada M.、Fukai R.、Hashiguchi S.、Kishida H.、Ueda N.、Kudo Y.、Kugimoto C.、Nakano T.、Udaka N.、Miyatake S.、Miyake N.、Saitsu H.、Ito Y.、Takahashi K.、Nakamura H.、Tomita-Katsumoto A.、Takeuchi H.、Koyano S.、Matsumoto N.、Tanaka F.
    • Journal Title

      Clinical Genetics

      Volume: - Issue: 2 Pages: 232-238

    • DOI

      10.1111/cge.13371

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K16128, KAKENHI-PROJECT-15K09344, KAKENHI-PROJECT-17K10080, KAKENHI-PROJECT-18K07503, KAKENHI-PROJECT-18K07504, KAKENHI-PROJECT-17H01539
  • [Journal Article] Two cases of anaphylactic shock by methylprednisolone in neuromyelitis optica2018

    • Author(s)
      Takahashi Keita、Asano Tetsuya、Higashiyama Yuichi、Koyano Shigeru、Doi Hiroshi、Takeuchi Hideyuki、Tanaka Fumiaki
    • Journal Title

      Multiple Sclerosis Journal

      Volume: 24 Issue: 11 Pages: 1514-1516

    • DOI

      10.1177/1352458518763099

    • NAID

      120006808928

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07503, KAKENHI-PROJECT-18K15458
  • [Journal Article] Cerebrospinal fluid level of Nogo receptor 1 antagonist lateral olfactory tract usher substance (LOTUS) correlates inversely with the extent of neuroinflammation2018

    • Author(s)
      Takahashi Keita、Takeuchi Hideyuki、Kurihara Yuji、Doi Hiroshi、Kunii Misako、Tanaka Kenichi、Nakamura Haruko、Fukai Ryoko、Tomita-Katsumoto Atsuko、Tada Mikiko、Higashiyama Yuichi、Joki Hideto、Koyano Shigeru、Takei Kohtaro、Tanaka Fumiaki
    • Journal Title

      Journal of Neuroinflammation

      Volume: 15 Issue: 1 Pages: 46-46

    • DOI

      10.1186/s12974-018-1084-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K16128, KAKENHI-PROJECT-16K19518, KAKENHI-PROJECT-16K21268, KAKENHI-PROJECT-18K07503, KAKENHI-PROJECT-18K15458
  • [Journal Article] Cerebellar ataxia-dominant phenotype in patients with ERCC4 mutations2018

    • Author(s)
      Doi H、Koyano S、Miyatake S、Nakajima S、Nakazawa Y、Kunii M、Tomita-Katsumoto A、Oda K、Yamaguchi Y、Fukai R、Ikeda S、Kato R、Ogata K、Kubota S、Hayashi N、Takahashi K、Tada M、Tanaka K、Nakashima M、Tsurusaki Y et al.
    • Journal Title

      Journal of Human Genetics

      Volume: 63 Issue: 4 Pages: 417-423

    • DOI

      10.1038/s10038-017-0408-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K19536, KAKENHI-PROJECT-17K16128, KAKENHI-PROJECT-15H05333, KAKENHI-PROJECT-17H00783, KAKENHI-PROJECT-16H05357, KAKENHI-PROJECT-15K09344, KAKENHI-PROJECT-16K15526, KAKENHI-PROJECT-18K07503, KAKENHI-PROJECT-18K07504, KAKENHI-PROJECT-18K11639, KAKENHI-PROJECT-17H01539, KAKENHI-PROJECT-17H01877, KAKENHI-PROJECT-18H03372, KAKENHI-PROJECT-15H02654
  • [Journal Article] White matter hyperintensities on MRI in dementia with Lewy bodies, Parkinson's disease with dementia, and Alzheimer's disease2018

    • Author(s)
      Joki Hideto、Higashiyama Yuichi、Nakae Yoshiharu、Kugimoto Chiharu、Doi Hiroshi、Kimura Katsuo、Kishida Hitaru、Ueda Naohisa、Nakano Tatsu、Takahashi Tatsuya、Koyano Shigeru、Takeuchi Hideyuki、Tanaka Fumiaki
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 385 Pages: 99-104

    • DOI

      10.1016/j.jns.2017.12.018

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07503
  • [Journal Article] Confirmation of SLC5A7-related distal hereditary motor neuropathy 7 in a family outside Wales2018

    • Author(s)
      Hamanaka K.、Takahashi K.、Miyatake S.、Mitsuhashi S.、Hamanoue H.、Miyaji Y.、Fukai R.、Doi H.、Fujita A.、Imagawa E.、Iwama K.、Nakashima M.、Mizuguchi T.、Takata A.、Miyake N.、Takeuchi H.、Tanaka F.、Matsumoto N.
    • Journal Title

      Clinical Genetics

      Volume: 94 Issue: 2 Pages: 274-275

    • DOI

      10.1111/cge.13369

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K10080, KAKENHI-PROJECT-18K07503, KAKENHI-PROJECT-17H01539, KAKENHI-PROJECT-16H06254, KAKENHI-PROJECT-17K15630
  • [Journal Article] A Case of McLeod Syndrome with A Novel XK Missense Mutation2018

    • Author(s)
      Komiya H, Takasu M, Hashiguchi S, Uematsu E, Fukai R, Tanaka K, Tada M, Joki H, Takahashi T, Koyano S, Doi H, Takeuchi H, Tanaka F
    • Journal Title

      Mov Disord Clin Pract.

      Volume: 5 Issue: 3 Pages: 333-336

    • DOI

      10.1002/mdc3.12614

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07504
  • [Journal Article] Differential activation of neuronal and glial STAT3 in the spinal cord of the SOD1 G93A mouse model of amyotrophic lateral sclerosis2017

    • Author(s)
      Ohgomori Tomohiro、Yamasaki Ryo、Takeuchi Hideyuki、Kadomatsu Kenji、Kira Jun-ichi、Jinno Shozo
    • Journal Title

      Eur J Neurosci.

      Volume: 46 Issue: 4 Pages: 2001-2014

    • DOI

      10.1111/ejn.13650

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K00858, KAKENHI-PROJECT-16H05139, KAKENHI-PLANNED-25117012, KAKENHI-PROJECT-15H04267, KAKENHI-PROJECT-15K09338
  • [Journal Article] Interleukin-19 Acts as a Negative Autocrine Regulator of Activated Microglia2015

    • Author(s)
      Hiroshi Horiuchi, Bijay Parajuli, Yue Wang, Yasu-Taka Azuma, Tetsuya Mizuno, Hideyuki Takeuchi, Akio Suzumura
    • Journal Title

      PLOS ONE

      Volume: 10 Issue: 3 Pages: e0118640-e0118640

    • DOI

      10.1371/journal.pone.0118640

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24591258
  • [Journal Article] Evidence for Aberrant Astrocyte Hemichannel Activity in Juvenile Neuronal Ceroid Lipofuscinosis (JNCL).2014

    • Author(s)
      Maria Burkovetskaya, Nikolay Karpuk, Juan Xiong, Megan Bosch, Michael D Boska, Hideyuki Takeuchi, Akio Suzumura, Tammy Kielian
    • Journal Title

      PLoS ONE

      Volume: 9(4) Issue: 4 Pages: e95023-e95023

    • DOI

      10.1371/journal.pone.0095023

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-24111520
  • [Journal Article] FGF-2 released from degenerating neurons exerts microglial-induced neuroprotection via FGFR3-ERK signaling pathway.2014

    • Author(s)
      Mariko Noda, Kento Takii, Bijay Parajuli, Jun Kawanokuchi, Yoshifumi Sonobe, Hideyuki Takeuchi, Tetsuya Mizuno, Akio Suzumura
    • Journal Title

      Journal of Neuroinflammation

      Volume: 11(1) Issue: 1 Pages: 76-76

    • DOI

      10.1186/1742-2094-11-76

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-24111520, KAKENHI-PROJECT-26670441
  • [Journal Article] Midkine and multiple sclerosis.2014

    • Author(s)
      Hideyuki Takeuchi
    • Journal Title

      British Journal of Pharmacology

      Volume: 171(4) Issue: 4 Pages: 931-935

    • DOI

      10.1111/bph.12499

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-24111520
  • [Journal Article] Gap junctions and hemichannels composed of connexins: potential therapeutic targets for neurodegenerative diseases2014

    • Author(s)
      Hideyuki Takeuchi, Akio Suzumura
    • Journal Title

      Frontiers in Cellular Neuroscience

      Volume: 8 Pages: 189-189

    • DOI

      10.3389/fncel.2014.00189

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24591258
  • [Journal Article] Sirtuin 1 attenuates oxidative stress via upregulation of superoxide dismutase 2 and catalase in astrocytes2014

    • Author(s)
      Yi Cheng, Hideyuki Takeuchi, Yoshifumi Sonobe, Shijie Jin, Yue Wang, Hiroshi Horiuchi, Bijay Parajuli, Jun Kawanokuchi, Tetsuya Mizuno, Akio Suzumura
    • Journal Title

      Journal of neuroimmunology

      Volume: 269(1-2) Issue: 1-2 Pages: 38-43

    • DOI

      10.1016/j.jneuroim.2014.02.001

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-24111520, KAKENHI-PROJECT-24591258
  • [Journal Article] GM-CSF increases LPS-induced production of proinflammatory mediators via upregulation of TLR4 and CD14 in murine microglia.2013

    • Author(s)
      Bijay Parajuli, Yoshifumi Sonobe, Jun Kawanokuchi, Yukiko Doi, Mariko Noda, Hideyuki Takeuchi, Tetsuya Mizuno, Akio Suzumura
    • Journal Title

      Journal of Neuroinflammation

      Volume: 9(1) Issue: 1 Pages: 268-268

    • DOI

      10.1186/1742-2094-9-268

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-24111520, KAKENHI-PROJECT-24591258, KAKENHI-PROJECT-24659430
  • [Journal Article] Minocycline selectively inhibits M1 polarization of microglia2013

    • Author(s)
      Kazuyoshi Kobayashi
    • Journal Title

      Cell Death and Disease

      Volume: 4 Issue: 3 Pages: e525-e525

    • DOI

      10.1038/cddis.2013.54

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23790360, KAKENHI-PUBLICLY-24111520, KAKENHI-PROJECT-24590349, KAKENHI-PROJECT-24591258, KAKENHI-PROJECT-24890084, KAKENHI-PROJECT-25860234
  • [Journal Article] Fingolimod phosphate promotes the neuroprotective effects of microglia.2013

    • Author(s)
      Hiromi Noda, Hideyuki Takeuchi, Tetsuya Mizuno, Akio Suzumura
    • Journal Title

      Journal of neuroimmunology

      Volume: 256(1-2) Issue: 1-2 Pages: 13-18

    • DOI

      10.1016/j.jneuroim.2012.12.005

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-24111520, KAKENHI-PROJECT-24591258
  • [Journal Article] Oligomeric amyloid β induces IL-1β processing via production of ROS: implication in Alzheimer's disease.2013

    • Author(s)
      B Parajuli, Y Sonobe, H Horiuchi, H Takeuchi, T Mizuno, A Suzumura
    • Journal Title

      Cell Death & Disease

      Volume: 4 Issue: 12 Pages: e975-e975

    • DOI

      10.1038/cddis.2013.503

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-24111520, KAKENHI-PROJECT-24659430
  • [Journal Article] Fingolimod Phosphate Attenuates Oligomeric Amyloid β-Induced Neurotoxicity via Increased Brain-Derived Neurotrophic Factor Expression in Neurons.2013

    • Author(s)
      Yukiko Doi, Hideyuki Takeuchi, Hiroshi Horiuchi, Taketo Hanyu, Jun Kawanokuchi, Shijie Jin, Bijay Parajuli, Yoshifumi Sonobe, Tetsuya Mizuno, Akio Suzumura
    • Journal Title

      PLoS ONE

      Volume: 8(4) Issue: 4 Pages: e61988-e61988

    • DOI

      10.1371/journal.pone.0061988

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-24111520
  • [Journal Article] Ablation of Keratan Sulfate Accelerates Early Phase Pathogenesis of ALS.2013

    • Author(s)
      Kenichi Hirano, Tomohiro Ohgomori, Kazuyoshi Kobayashi, Fumiaki Tanaka, Tomohiro Matsumoto, Takamitsu Natori, Yukihiro Matsuyama, Kenji Uchimura, Kazuma Sakamoto, Hideyuki Takeuchi, Akihiro Hirakawa, Akio Suzumura, Gen Sobue, Naoki Ishiguro, Shiro Imagama, Kenji Kadomatsu
    • Journal Title

      PLoS ONE

      Volume: 8(6) Issue: 6 Pages: e66969-e66969

    • DOI

      10.1371/journal.pone.0066969

    • NAID

      120005946841

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-24111520, KAKENHI-PROJECT-24890084, KAKENHI-PROJECT-25293207, KAKENHI-PROJECT-25860234
  • [Journal Article] The neuroprotective effects of milk fat globule-EGF factor 8 against oligomeric amyloid β toxicity.2012

    • Author(s)
      Li E, Noda M, Doi Y, Parajuli B, Kawanokuchi J, Sonobe Y, Takeuchi H, Mizuno T, Suzumura A.
    • Journal Title

      Journal of Neuroinflammation

      Volume: 9 Issue: 1 Pages: 148-148

    • DOI

      10.1186/1742-2094-9-148

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591258, KAKENHI-PUBLICLY-24111520
  • [Journal Article] Midkine inhibits inducible regulatory T cell differentiation by suppressing the development of tolerogenic dendritic cells2012

    • Author(s)
      SONOBE Yoshifumi
    • Journal Title

      Journal of Immunology

      Volume: 188(6) Issue: 6 Pages: 2602-2611

    • DOI

      10.4049/jimmunol.1102346

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790816, KAKENHI-PROJECT-23390078, KAKENHI-PUBLICLY-24111520
  • [Journal Article] TGF-β induced by interleukin-34-stimulated microglia regulates microglial proliferation and attenuates oligomeric amyloid β neurotoxicity2012

    • Author(s)
      Ma D, Doi Y, Jin S, Li E, Sonobe Y, Takeuchi H, Mizuno T, Suzumura A
    • Journal Title

      Neuroscience Letters

      Volume: 529(1) Issue: 1 Pages: 86-91

    • DOI

      10.1016/j.neulet.2012.08.071

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591258, KAKENHI-PROJECT-24659430, KAKENHI-PUBLICLY-24111520
  • [Journal Article] Immunoglobulin G_1 immune complex upregulates interferon-γ induced nitrie oxide production via ERK1/2 activation in murine microglia2011

    • Author(s)
      PARAJULI Bijay
    • Journal Title

      Journal of Neuroimmunology

      Volume: 244(1-2) Issue: 1-2 Pages: 57-62

    • DOI

      10.1016/j.jneuroim.2012.01.004

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790816, KAKENHI-PUBLICLY-24111520
  • [Journal Article] Interferon-γ induces microglial activation-induced cell death : a hypothetical mechanism of relapse and remission in multiple sclerosis.2006

    • Author(s)
      TAKEUCHI Hideyuki, et al.
    • Journal Title

      Neurobiology of Disease 22

      Pages: 33-39

    • Data Source
      KAKENHI-PROJECT-17790577
  • [Journal Article] Tumor necrosis factor-α induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner2006

    • Author(s)
      TAKEUCHI Hideyuki, et al.
    • Journal Title

      The Journal of Biological Chemistry 281

      Pages: 21362-21368

    • Data Source
      KAKENHI-PROJECT-17790577
  • [Journal Article] Neuritic beading induced by activated microglia is an early feature of neuronal dysfunction toward neuronal death by inhibition of mitochondrial respiration and axonal transport.2005

    • Author(s)
      TAKEUCHI Hideyuki, et al.
    • Journal Title

      The Journal of Biological Chemistry 280・11

      Pages: 10444-10454

    • Data Source
      KAKENHI-PROJECT-17790577
  • [Patent] グリチルレチン酸誘導体及びその利用2014

    • Inventor(s)
      竹内英之、錫村明生
    • Industrial Property Rights Holder
      名古屋大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-11-20
    • Overseas
    • Data Source
      KAKENHI-PROJECT-24591258
  • [Patent] 特願2013-2431302013

    • Inventor(s)
      竹内英之、錫村明生
    • Industrial Property Rights Holder
      竹内英之、錫村明生
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-11-25
    • Data Source
      KAKENHI-PUBLICLY-24111520
  • [Patent] 神経細胞の細胞死阻害剤及びスクリーニング方法2006

    • Inventor(s)
      竹内英之, 錫村明生
    • Industrial Property Rights Holder
      名古屋大学
    • Filing Date
      2006-02-01
    • Data Source
      KAKENHI-PROJECT-17790577
  • [Patent] 神経細胞の細胞死阻害剤及びスクリーニング方法2006

    • Inventor(s)
      竹内 英之, 錫村 明生
    • Industrial Property Rights Holder
      名古屋大学
    • Industrial Property Number
      2006-026144
    • Filing Date
      2006-02-02
    • Data Source
      KAKENHI-PROJECT-17790577
  • [Presentation] 両アレル性AAGGGおよびACAGGリピート伸長を持つCerebellar ataxia with neuropathy and vestibular areflexia syndrome (CANVAS) 剖検2例におけるRNA fociの形成2024

    • Author(s)
      和田大司, 土井宏, 大久保正紀, 多田美紀子, 上田直久, 冨永和奏, 小池春樹, 中村治子, 高橋慶太, 國井美紗子, 宮地洋輔, 東山雄一, 宮武聡子, 勝野雅央, 藤井誠志, 松本直通, 竹内英之 ,田中章景.
    • Organizer
      日本小脳学会 第14回学術大会
    • Data Source
      KAKENHI-PROJECT-21K07440
  • [Presentation] Pathological evaluations of patients of CANVAS with biallelic expansion of AAGGG and ACAGG repeats.2023

    • Author(s)
      和田大司, 土井宏, 大久保正紀, 多田美紀子, 上田直久, 冨永和奏, 小池春樹, 細田航平, 中村治子, 高橋慶太, 國井美紗子, 宮地洋輔, 東山雄一, 宮武聡子, 勝野雅央, 藤井誠志, 松本直通, 竹内英之, 田中章景
    • Organizer
      第64回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-21K07298
  • [Presentation] Connexin hemichannel blockade ameliorates EAE by suppressing glial inflammation2023

    • Author(s)
      Ezgi Ozdemir Takase, Ryo Yamasaki, Satoshi Nagata, Mitsuru Watanabe, Katsuhisa Masaki, Hiroo Yamaguchi, Jun-ichi Kira, Hideyuki Takeuchi, Noriko Isobe
    • Organizer
      European Charcot Foundation Annual Meeting 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K18266
  • [Presentation] グリア細胞からみた脳内炎症とその治療2023

    • Author(s)
      竹内 英之
    • Organizer
      第64回日本神経学会学術大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K07465
  • [Presentation] Pathological evaluations of patients of CANVAS with biallelic expansion of AAGGG and ACAGG repeats2023

    • Author(s)
      Wada T, Doi H, Okubo M, Tada M, Ueda N, Tominaga W, Koike H, Hosoda K, Nakamura H, Takahashi K, Kunii M, Miyaji Y, Higashiyama Y, Miyatake S, Katsuno M, Fujii S, Matsumoto N, Takeuchi H, Tanaka F.
    • Organizer
      64th Annual Meeting of the Japnese Society of Neurology
    • Data Source
      KAKENHI-PROJECT-21K07440
  • [Presentation] グリア細胞と神経変性疾患2023

    • Author(s)
      竹内 英之
    • Organizer
      第35回日本神経免疫学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K07465
  • [Presentation] Analysis of genetic background of adult leukoencephalopathies.2023

    • Author(s)
      土井宏, 大久保正紀, 深井綾子, 國井美紗子, 和田大司, 岸田日帯, 工藤洋祐, 山口滋紀, 高橋慶太, 多田美紀子, 宮武聡子, 伊藤泰広, 上田直久, 児矢野繁, 竹内英之, 松本直通, 田中章景
    • Organizer
      第64回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-21K07298
  • [Presentation] Nogo受容体の内因性アンタゴニストであるLOTUSはALSモデルマウスの症状を改善する2022

    • Author(s)
      池田拓也,髙橋慶太,橋口俊太,田中健一,土井宏,竹居光太郎,竹内英之,田中章景
    • Organizer
      第40回日本神経治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K07465
  • [Presentation] A novel automated quantitative system for LOTUS, a candidate biomarker for disease activity in MS2022

    • Author(s)
      高橋慶太、竹内英之、国井美紗子、池田拓也、橋口俊太、田中健一、勝元敦子、多田美紀子、土井宏、田中章景
    • Organizer
      第63回日本神経学会学術大会,
    • Data Source
      KAKENHI-PROJECT-20K07761
  • [Presentation] CRMP1のリン酸化阻害は筋萎縮性側索硬化症モデルマウスの生存期間,運動機能の改善をもたらす2022

    • Author(s)
      浅野徹也,中村治子,川本裕子,多田美紀子,木村弥生,高野洋志,八尾良司,橋口俊太,髙橋慶太,國井美紗子,田中健一,五嶋良郎,中村史雄,竹内英之,土井宏,田中章景
    • Organizer
      第40回日本神経治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K07465
  • [Presentation] Anti-inflammatory effects of siponimod on astrocyte.2022

    • Author(s)
      小笠原陽大,竹内英之,古宮裕泰,小川有紀,髙橋慶太,橋口俊太,國井美紗子,多田美紀子,田中健一,土井宏,田中章景
    • Organizer
      第63回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-21K07465
  • [Presentation] Ser522-phosphorylation of CRMP1 modulates the motor function of amyotrophic lateral sclerosis mice.2022

    • Author(s)
      浅野徹也,中村治子,川本裕子,多田美紀子,木村弥生,高野洋志,八尾良司,橋口俊太,髙橋慶太,國井美紗子,田中健一,五嶋良郎,中村史雄,竹内英之,土井宏,田中章景
    • Organizer
      第63回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-21K07465
  • [Presentation] Ethosuximide improves clinical and pathological phenotypes of SCA42 mouse model.2022

    • Author(s)
      Shunta Hashiguchi, Hiroshi Doi, Masaki Okubo, Misako Kunii, Keita Takahashi, Mikiko Tada, Kenichi Tanaka, Hideyuki Takeuchi, Taro Ishikawa, Fumiaki Tanaka
    • Organizer
      第63回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-21K07298
  • [Presentation] LOTUS, an Nogo receptor antagonist, improves phenotypes of ALS.2022

    • Author(s)
      池田拓也,髙橋慶太,橋口俊太,國井美紗子,田中健一,多田美紀子,土井宏,竹居光太郎,竹内英之,田中章景
    • Organizer
      第63回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-21K07465
  • [Presentation] Anti-inflammatory effects of siponimod on astrocyte.2022

    • Author(s)
      小笠原陽大,竹内英之,古宮裕泰,小川有紀,髙橋慶太,橋口俊太,國井美紗子,多田美紀子,田中健一,土井宏,田中章景
    • Organizer
      第45回日本神経科学大会/第65回日本神経化学会大会/第32回日本神経回路学会大会
    • Data Source
      KAKENHI-PROJECT-21K07465
  • [Presentation] ミクログリアに対するインフラマソームを介したシポニモドの抗炎症作用2022

    • Author(s)
      古宮裕泰,竹内英之,小笠原陽大,髙橋慶太,田中健一,多田美紀子,土井宏,田中章景
    • Organizer
      第34回日本神経免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K07465
  • [Presentation] Axonal accumulation of phosphorylated CRMP1 in human ALS spinal cords.2022

    • Author(s)
      川本裕子,浅野徹也,中村治子,多田美紀子,橋口俊太,髙橋慶太,國井美紗子,田中健一,五嶋良郎,竹内英之,土井宏,中村史雄,田中章景
    • Organizer
      第63回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-21K07465
  • [Presentation] Ser522-phosphorylation of CRMP1 modulates the motor function of amyotrophic lateral sclerosis mice.2022

    • Author(s)
      浅野徹也,中村治子,川本裕子,多田美紀子,木村弥生,高野洋志,八尾良司,橋口俊太,髙橋慶太,國井美紗子,田中健一,五嶋良郎,中村史雄,竹内英之,土井宏,田中章景
    • Organizer
      第45回日本神経科学大会/第65回日本神経化学会大会/第32回日本神経回路学会大会
    • Data Source
      KAKENHI-PROJECT-21K07465
  • [Presentation] Ethosuximide improves clinical and pathological phenotypes of SCA42 mouse model.2022

    • Author(s)
      Masaki Okubo, Hiroshi Doi, Shunta Hashiguchi, Misako Kunii, Keita Takahashi, Mikiko Tada, Kenichi Tanaka, Hideyuki Takeuchi, Taro Ishikawa, Fumiaki Tanaka
    • Organizer
      第45回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-21K07298
  • [Presentation] Ablation of interleukin-19 improves motor function in a mouse model of amyotrophic lateral sclerosis.2021

    • Author(s)
      Komiya H, Takeuchi H, Ogawa Y, Ogasawara A, Takahashi K, Doi H, Tanaka F.
    • Organizer
      15th International Society of Neuroimmunology Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07465
  • [Presentation] An Endogenous Nogo receptor antagonist LOTUS, a novel therapeutic target for ALS2021

    • Author(s)
      Takuya Ikeda, Keita Takahashi, Hiroshi Doi, Kohtaro Takei, Hideyuki Takeuchi, Fumiaki Tanaka
    • Organizer
      Pan-Asia Consortium for Treatment and Research in ALS
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07761
  • [Presentation] Astroglial connexin 43 Is a novel therapeutic target for a chronic multiple sclerosis model.2021

    • Author(s)
      Ozdemir E, Yamasaki R, Nagata S, Yamaguchi H, Masaki K, Kira JI, Takeuchi H, Isobe N.
    • Organizer
      15th International Society of Neuroimmunology Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07465
  • [Presentation] Anti-inflammatory effects of siponimod on astrocyte.2021

    • Author(s)
      Ogasawara A, Takeuchi H, Komiya H, Ogawa Y, Takahashi K, Doi H, Tanaka F.
    • Organizer
      15th International Society of Neuroimmunology Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07465
  • [Presentation] RNA helicases DDX5 and DDX17 are involved in sporadic ALS pathology.2021

    • Author(s)
      Mikiko Tada, Hiroshi Doi, Shingo Ikeda, Shunta Hashiguchi, Keita Takahashi, Misako Kunii, Kenichi Tanaka, Shigeru Koyano, Hideyuki Takeuchi, Fumiaki Tanaka
    • Organizer
      62nd Annual Meeting of Japanese Society of Neurology
    • Data Source
      KAKENHI-PROJECT-19K07845
  • [Presentation] Identification of intronic repeat expansion of RFC1 by long-read sequencer.2021

    • Author(s)
      土井宏、中村治子、宮武聡子、三橋里美、水口剛、大久保正紀、工藤洋祐、浅野徹也、國井美紗子、田中健一、多田美紀子、上木英人、竹内英之、松本直通、田中章景
    • Organizer
      第62回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-21K07298
  • [Presentation] Ablation of interleukin-19 improves motor function in a mouse model of amyotrophic lateral sclerosis.2021

    • Author(s)
      Komiya H, Takeuchi H, Ogasawara A, Ogawa Y, Takahashi K, Doi H, Tanaka F.
    • Organizer
      Pan-Asia Consortium for Treatment and Research in ALS
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07465
  • [Presentation] CCR2 is localized in microglia and neurons, as well as infiltrating monocytes, in the lumbar spinal cord of ALS mice.2021

    • Author(s)
      Ogasawara A, Takeuchi H, Komiya H, Ogawa Y, Takahashi K, Doi H, Tanaka F.
    • Organizer
      Pan-Asia Consortium for Treatment and Research in ALS
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07465
  • [Presentation] Ataxic phenotype with altered CaV3.1 channel property in a mouse model for spinocerebellar ataxia 422020

    • Author(s)
      橋口俊太,土井宏,國井美紗子,中村行宏,志牟田美佐,鈴木江津子,大久保正紀, 窪田瞬,多田美紀子,児矢野繁,竹内英之,石川太郎,田中章景
    • Organizer
      第61回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-18K07503
  • [Presentation] Genetic analysis of adult leukoencephalopathies2020

    • Author(s)
      土井宏,大久保正紀,深井綾子,國井美紗子,岸田日帯,高橋慶太,勝元敦子,多田美紀子,藤田京志,三橋里美,宮武聡子,伊藤泰広, 上田直久,児矢野繁,竹内英之,松本直通,田中章景
    • Organizer
      第61回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-18K07503
  • [Presentation] Evaluation of serum LOTUS as a biomarker of neuroinflammation2020

    • Author(s)
      Keita Takahashi, Hideyuki Takeuchi, Misako Kunii, Ken-ichi Tanaka, Mikiko Tada, Kohtaro Takei, Fumiaki Tanaka
    • Organizer
      日本神経学会
    • Data Source
      KAKENHI-PROJECT-20K07761
  • [Presentation] DDX5 accumulates in neuronal cytoplasmic inclusions with TDP-43 in SALS.2020

    • Author(s)
      Mikiko Tada, Hiroshi Doi, Shingo Ikeda, Shunta Hashiguchi, Atsuko Katsumoto, Misako Kunii, Keita Takahashi, Koyano Shigeru, Hideyuki Takeuchi, Fumiaki Tanaka
    • Organizer
      61st Annual Meeting of the Japanese Society of Neurology, Okayama, 2020,5.
    • Data Source
      KAKENHI-PROJECT-19K07845
  • [Presentation] シンポジウム「神経免疫と認知症・精神疾患」・神経免疫と精神・神経疾患2020

    • Author(s)
      竹内 英之
    • Organizer
      第32回日本神経免疫学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K07531
  • [Presentation] DDX5 accumulates in neuronal cytoplasmic inclusions with TDP-43 in SALS.2020

    • Author(s)
      Mikiko Tada,Hiroshi Doi,Shingo Ikeda,Shunta Hashiguchi,Atsuko Katsumoto,Misako Kunii,Keita Takahashi,Koyano Shigeru, Hideyuki Takeuchi, Fumiaki Tanaka
    • Organizer
      第61回日本神経学会総会
    • Data Source
      KAKENHI-PROJECT-19K07845
  • [Presentation] シンポジウム「神経免疫疾患の病態解明への多面的アプローチ」・グリア細胞からのアプローチ.2019

    • Author(s)
      竹内英之
    • Organizer
      第60回日本神経学会学術大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K07531
  • [Presentation] Ataxic phenotype with altered CaV3.1 channel property in a mouse model for spinocerebellar ataxia 42.2019

    • Author(s)
      Hiroshi Doi, Shunta Hashiguchi, Misako Kunii, Yukihiro Nakamura, Misa Shimuta, Etsuko Suzuki, Masaki Okubo, Toshikuni Sasaoka, Hideyuki Takeuchi, Taro Ishikawa, Fumiaki Tanaka
    • Organizer
      Neuroscience 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07503
  • [Presentation] Gap junction/hemichannel blockers ameliorate a mouse model of neuropathic pain.2018

    • Author(s)
      竹内英之
    • Organizer
      第59回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-18K07531
  • [Presentation] グリアを標的とした神経疾患の治療法開発2018

    • Author(s)
      竹内英之
    • Organizer
      第61回日本神経化学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K07531
  • [Presentation] 血管内大細胞性B細胞リンパ腫を併発し、R-CHOP療法で劇的な改善を認めた抗SRP抗体陽性筋炎の1例2018

    • Author(s)
      古宮 裕泰, 児矢野 繁, 土井 宏, 西野 一三, 竹内 英之, 田中 章景
    • Organizer
      第36回日本神経治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K07504
  • [Presentation] Clinical characteristics of four patients with ERCC4 mutations manifesting ataxia phenotype.2018

    • Author(s)
      土井 宏, 児矢野繁, 宮武聡子, 中島伸二, 中沢由華, 國井美紗子, 勝元敦子, 深井綾子, 荻朋男, 竹内英之, 松本直通, 田中章景
    • Organizer
      第59回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-18K07503
  • [Presentation] Gap junction/hemichannel blockers ameliorate the disease progression of FTLD/ALS mice.2017

    • Author(s)
      Takeuchi H, Mizoguchi H, Tanaka F, Suzumura A
    • Organizer
      The XXIII World Congress of Neurology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09338
  • [Presentation] FTY720 はミクログリアの炎症作用を抑え神経保護作用を上昇させる2012

    • Author(s)
      野田裕美(竹内英之)
    • Organizer
      第24回神経免疫学会学術集会
    • Place of Presentation
      軽井沢
    • Year and Date
      2012-09-19
    • Data Source
      KAKENHI-PUBLICLY-24111520
  • [Presentation] GM-CSF increases proinflammatory cytokineproduction via upregulation of TLR4 and CD14 in microglia.2012

    • Author(s)
      Parajuli B (竹内英之)
    • Organizer
      第24回神経免疫学会学術集会
    • Place of Presentation
      軽井沢
    • Year and Date
      2012-09-19
    • Data Source
      KAKENHI-PUBLICLY-24111520
  • [Presentation] FTY720 has the effects of anti-neuroinflammation and neuroprotection on microglia.2012

    • Author(s)
      Noda H (Takeuchi H)
    • Organizer
      11th International Congress of Neuroimmunology
    • Place of Presentation
      Boston, USA
    • Year and Date
      2012-11-04
    • Data Source
      KAKENHI-PUBLICLY-24111520
  • [Presentation] FTY720 has the effects of anti-neuroinflammation and neuroprotection on microglia.2012

    • Author(s)
      Noda H (Takeuchi H)
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2012-12-05
    • Data Source
      KAKENHI-PUBLICLY-24111520
  • [Presentation] Roles of glial calls in neuroinflammation and neurodegeneration.

    • Author(s)
      TAKEUCHI Hideyuki
    • Organizer
      12th MS Workshop
    • Place of Presentation
      福岡
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-24111520
  • [Presentation] FTY720はBDNFの発現上昇を介してアミロイドβによる神経細胞死を抑制する

    • Author(s)
      竹内英之, 土井由紀子, 薗部佳史, 水野哲也, 錫村明生
    • Organizer
      第54回日本神経学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PUBLICLY-24111520
  • [Presentation] フィンゴリモドの神経保護作用

    • Author(s)
      竹内英之
    • Organizer
      第18回グリア研究会
    • Place of Presentation
      仙台
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-24111520
  • [Presentation] Ablation of neuronal TDP-43 develops FTLD/ALS phenotypes in mice.

    • Author(s)
      3. TAKEUCHI Hideyuki, HORIUCHI Hiroshi, MIZOGUCHI Hiroyuki, SUZUMURA Akio, KWONG Linda, TROJANOWSKI John, LEE Virginia
    • Organizer
      Neuroscience2013, Annual Meeting of Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Data Source
      KAKENHI-PROJECT-24591258
  • [Presentation] Fingolimodの神経保護作用

    • Author(s)
      竹内英之, 金 世杰, 土井由紀子, 堀内 浩, 川ノ口潤, 水野哲也, 錫村明生
    • Organizer
      第25回日本神経免疫学会学術集会
    • Place of Presentation
      下関
    • Data Source
      KAKENHI-PUBLICLY-24111520
  • [Presentation] 薬剤誘導性神経特異的TDP-43ノックアウトマウスはFTLD/ALSの表現型を呈する

    • Author(s)
      竹内英之
    • Organizer
      第55回日本神経学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-05-21 – 2014-05-25
    • Data Source
      KAKENHI-PROJECT-24591258
  • [Presentation] 可溶性Aβオリゴマーによるミクログリアの神経傷害作用

    • Author(s)
      PARAJULI Bijay, 水野哲也, 竹内英之, 錫村明生
    • Organizer
      第25回日本神経免疫学会学術集会
    • Place of Presentation
      下関
    • Data Source
      KAKENHI-PUBLICLY-24111520
  • [Presentation] Fingolimod protects axonal damage in experimental autoimmune encephalomyelitis

    • Author(s)
      JIN Shijie, TAKEUCHI Hideyuki, MIZUNO Tetsuya, SUZUMURA Akio
    • Organizer
      PACTRIMS2013, Annual Meeting of Pan-Asian Committee for Treatment and Research in Multiple Sclerosis
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PUBLICLY-24111520
  • [Presentation] 脳移行性CpGのアルツハイマー病モデルマウスの認知機能障害に対する有用性の検討

    • Author(s)
      水野哲也, 土井由紀子, 竹内英之, 錫村明生
    • Organizer
      第54回日本神経学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PUBLICLY-24111520
  • 1.  TANAKA Fumiaki (30378012)
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