Kawai Hidehiko 河合秀彦

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KAWAI Hidehiko 河合秀彦

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Researcher Number	30379846
Other IDs
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Affiliation (Current)	2025: 広島大学, 医系科学研究科(薬), 准教授
Affiliation (based on the past Project Information) *help	2019 – 2025: 広島大学, 医系科学研究科(薬), 准教授 2018: 広島大学, 大学院医歯薬保健学研究科(薬), 准教授 2017 – 2018: 広島大学, 医歯薬保健学研究科(薬), 准教授 2011 – 2016: 広島大学, 原爆放射線医科学研究所, 助教 2007 – 2009: Hiroshima University, Research Institute for Radiation Biology and Medicine, Assistant Professor 2005 – 2006: 広島大学, 原爆放射線医科学研究所, 助手
Review Section/Research Field	Principal Investigator Basic Section 63020:Radiation influence-related / Risk sciences of radiation/Chemicals / Risk sciences of radiation and chemicals Except Principal Investigator Risk sciences of radiation and chemicals / Basic Section 63030:Chemical substance influence on environment-related / Risk sciences of radiation/Chemicals / Medium-sized Section 47:Pharmaceutical sciences and related fields / Basic Section 48030:Pharmacology-related / Health science and related fields / Surgical dentistry / Biological pharmacy
Keywords	Principal Investigator 放射線 / がん / p53 / 細胞老化 / 放射線被曝 / 幹細胞 / ゲノム安定性 / 細胞応答 / iPS細胞 / MDM2 … More / 老化 / 微小環境 / 変異 / 発がん / 細胞運命 / ハイスループットスクリーニング / 持続放射線照射 / ゲノム編集 / 緩照射 / 急照射 / 放射線照射条件 / ゲノム安定性維持機構 / 放射線影響 / 照射線量率 / 応答 / 放射線応答 / MDM2-MDMX複合体 / ユビキチン化修飾 / P53 / ユビキチン-プロテアソーム / 電離放射線 / MDMX … More Except Principal Investigator 放射線発がん / 放射線 / 活性酸素 / APOBEC3 / 遠隔作用変異 / 8-hydroxyguanine / 低線量・低線量率 / p53 / Survivin / 細胞周期 / 二次元電気泳動 / プロテオーム解析 / 質量分析装置 / γ線 / DNA 損傷 / 抗癌剤 / 8-hydroxy-dGTP / 酸化損傷ヌクレオチド / DNA損傷 / プロテインキナーゼC / 神経変性疾患 / 小胞体関連分解 / 膜輸送 / セロトニントランスポーター / 小胞体ストレス / 細胞老化関連分泌形質（SASP） / 細胞老化関連分泌物質(SASP) / 細胞老化関連分泌形質(SASP) / 細胞老化関連分泌物質 / モデルマウス / 放射線持続照射 / 健康寿命延伸 / SASP / 老化 / 低線量 / 低線量、低線量率 / 遺伝子改変マウス / 細胞老化 / 低線量（率）放射線発がんリスク / 年齢依存性 / 動物モデル / 幹細胞 / 低線量(率) / 発がん / 発癌 / Borealin / 染色体パッセンジャータンパク / 細胞分裂 / 口腔癌 / ユビキチン分解 / 染色体パッセンジャー複合体 / Ribosome / Cellular response / Radiation / Aurora kinase / Cell cycle / Apoptosis / シグナル伝達因子 / 紫外線 / Ribosomal protein / MDM2 / Aurora / リボソーム / 細胞応答 / Auroraキナーゼ / アポトーシス / 遺伝子修正 / ゲノム編集 / 人工ヌクレアーゼ / iPS細胞 / ウェルナー症候群 / １細胞シーケンス / 1細胞 / 次世代シーケンサー / 線量推定 / マウス胸腺 / X線 / 放射線被ぼく / HPLC / タンパク質分解 / LyGDI / マウス / 放射線被ばく Less

放射線誘発性細胞老化と細胞傷害による多層的変異シグネチャー生成メカニズムの解析Principal Investigator
- Principal Investigator
  
  河合秀彦
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Hiroshima University
抗癌剤スクリーニングを志向した酸化損傷ヌクレオチドの可視化
- Principal Investigator
  
  紙谷浩之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Hiroshima University
老化細胞誘発クラスター性変異のNGS解析による放射線発がん機構研究Principal Investigator
- Principal Investigator
  
  河合秀彦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Hiroshima University
活性酸素と脱アミノ化酵素APOBEC3が誘発する遠隔作用変異の分子機構の解明
- Principal Investigator
  
  紙谷浩之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  Hiroshima University
Analysis of the function of the senescent cells for exploring the link between ionizing radiation and carcinogenesisPrincipal Investigator
- Principal Investigator
  
  Kawai Hidehiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Hiroshima University
Identification of novel ER stress relieving drugs using a high-content microscope and application to therapeutic development
- Principal Investigator
  
  Sakai Norio
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Hiroshima University
Molecular mechanisms of action-at-a-distance mutations induced by DNA damage
- Principal Investigator
  
  KAMIYA Hiroyuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  Hiroshima University
Mechanism of low dose(rate) radiation induced tumor development by using intestinal stem cell organoid system
- Principal Investigator
  
  Sasatani Megumi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Hiroshima University
A novel study on the mechanisms of low-dose radiation-induced aging and carcinogenesis
- Principal Investigator
  
  Kamiya Kenji
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Hiroshima University
Development of mice model for elucidating the mechanism of healthy life expectancy extension
- Principal Investigator
  
  Kamiya Kenji
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Research Field
  
  Health science and related fields
- Research Institution
  Hiroshima University
Clarification of the mechanism of oral carcinogenesis by the defect of degradation of chromosome passenger complex protein
- Principal Investigator
  
  KUDO Yasusei
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokushima
Advanced radiation research using comprehensive multi-high-throughput technologiesPrincipal Investigator
- Principal Investigator
  
  Kawai Hidehiko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Hiroshima University
Advanced research on the biological effects of genotoxic stress using different irradiation conditions and induced pluripotent cellsPrincipal Investigator
- Principal Investigator
  
  KAWAI HIDEHIKO
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Hiroshima University
Analysis of radiation induced mutations using next generation sequencer
- Principal Investigator
  
  KANAI Akinori
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Hiroshima University
Gene correction in iPS cells of premature aging syndrome toward clinical application by genome editing
- Principal Investigator
  
  SHIMAMOTO Akira
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Hiroshima University
The analysis of cell-type specific cellular responses under different irradiation conditions and dynamic regulation of p53 functionsPrincipal Investigator
- Principal Investigator
  
  KAWAI Hidehiko
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Hiroshima University
Analysis of a novel mechanism for the p53 response to radiation by the MDM2-MDMX E3 ubiquitin ligase complexPrincipal Investigator
- Principal Investigator
  
  KAWAI Hidehiko
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Hiroshima University
尿タンパク質のプロテオーム解析による簡便な被ばく者障害リスク評価法の開発
- Principal Investigator
  
  SUZUKI Fumio
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Hiroshima University
電離放射線照射によるp53活性化機構におけるMDM2複合体の機能解析Principal Investigator
- Principal Investigator
  
  河合秀彦
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Hiroshima University
The search and analysis for essential signaling mediators responding to radiation by proteome techniques.
- Principal Investigator
  
  SUZUKI Fumio
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Hiroshima University

[Journal Article] Correction of substitution, deletion, and insertion mutations by 5'-tailed duplexes2024
- Author(s)
  Kawai H, Sato K, Kato T, Kamiya H.
- Journal Title
  
  J Biosci Bioeng
  
  Volume: 137(3) Issue: 3 Pages: 157-164
- DOI
  10.1016/j.jbiosc.2023.12.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K12375
[Journal Article] Methylmercury Decreases AMPA Receptor Subunit GluA2 Levels in Cultured Rat Cortical Neurons2023
- Author(s)
  Ishida K, Takeda K, Takehara Y, Takabayashi T, Miyara M, Sanoh S, Kawai H, Ohta S, Kotake Y
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 46 Issue: 2 Pages: 292-300
- DOI
  10.1248/bpb.b22-00744
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2023-02-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K12375, KAKENHI-PROJECT-20H04342
[Journal Article] Development of a versatile high-throughput mutagenesis assay with multiplexed short-read NGS using DNA-barcoded supF shuttle vector library amplified in E. coli2022
- Author(s)
  Kawai H, Iwata R, Ebi S, Sugihara R, Masuda S, Fujiwara C, Kimura S, Kamiya H
- Journal Title
  
  eLife
  
  Volume: 11
- DOI
  10.7554/elife.83780
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K12375
[Journal Article] Low-Dose-Rate Irradiation Suppresses the Expression of Cell Cycle-Related Genes, Resulting in Modification of Sensitivity to Anti-Cancer Drugs2022
- Author(s)
  Shimabukuro K, Fukazawa T, Kanai A, Kawai H, Mekata K, Hirohashi N, Kakimoto N, Tanimoto K.
- Journal Title
  
  Cells
  
  Volume: 11(3) Issue: 3 Pages: 501-501
- DOI
  10.3390/cells11030501
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K12322, KAKENHI-PROJECT-20K20310, KAKENHI-PROJECT-21K10073, KAKENHI-PROJECT-21K12239
[Journal Article] RFWD3 and translesion DNA polymerases contribute to PCNA modification dependent DNA damage tolerance2022
- Author(s)
  Kanao Rie、Kawai Hidehiko、Taniguchi Toshiyasu、Takata Minoru、Masutani Chikahide
- Journal Title
  
  Life Science Alliance
  
  Volume: 5 Issue: 12 Pages: e202201584-e202201584
- DOI
  10.26508/lsa.202201584
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K12238, KAKENHI-PROJECT-22K12375, KAKENHI-PROJECT-20K21394, KAKENHI-PROJECT-20H03450, KAKENHI-PROJECT-20H04335, KAKENHI-PROJECT-21K19843
[Journal Article] DDX41 coordinates RNA splicing and transcriptional elongation to prevent DNA replication stress in hematopoietic cells2022
- Author(s)
  Satoru Shinriki;Mayumi Hirayama;Akiko Nagamachi;Akihiko Yokoyama;Takeshi Kawamura;Akinori Kanai;Hidehiko Kawai;Junichi Iwakiri;Rin Liu;Manabu Maeshiro;Saruul Tungalag;Masayoshi Tasaki;Mitsuharu Ueda;Kazuhito Tomizawa;Naoyuki Kataoka;Takashi Ideue;Yutaka Suzuki;Kiyoshi Asai;Tokio Tani;Toshiya Inaba;Hirotaka Matsui
- Journal Title
  
  Leukemia
  
  Volume: 36 Issue: 11 Pages: 2605-2620
- DOI
  10.1038/s41375-022-01708-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06174, KAKENHI-PROJECT-21K08395, KAKENHI-PROJECT-21K08419, KAKENHI-PROJECT-21K12239, KAKENHI-PROJECT-22K10195, KAKENHI-PROJECT-22K12375, KAKENHI-PROJECT-22K20997, KAKENHI-PROJECT-22KK0119, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-21H02948, KAKENHI-PROJECT-20K12041, KAKENHI-PROJECT-23K24368
[Journal Article] Correction of monomeric enhanced green fluorescent protein (mEGFP) gene by short 5′-tailed duplexes2022
- Author(s)
  Kawai H, Kamitsubo R, Kamiya H
- Journal Title
  
  Journal of Bioscience and Bioengineering
  
  Volume: 134 Issue: 3 Pages: 175-181
- DOI
  10.1016/j.jbiosc.2022.06.014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K12375
[Journal Article] ACTIVATION OF HUMAN FIBROBLASTS BY CHRONIC RADIATION RATHER THAN ACUTE RADIATION2022
- Author(s)
  Shimura T, Zaharieva E, Sasatani M, Kawai H, Kamiya K, Ushiyama A
- Journal Title
  
  Radiation Protection Dosimetry
  
  Volume: 198 Issue: 13-15 Pages: 1098-1103
- DOI
  10.1093/rpd/ncac065
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K12375
[Journal Article] Gene correction by 5'-tailed duplexes with short editor oligodeoxyribonucleotides2021
- Author(s)
  Kawai H, Yazama K, Yanai Y, Kamitsubo R, Kamiya H.
- Journal Title
  
  J Biosci Bioeng
  
  Volume: 132(6) Issue: 6 Pages: 552-559
- DOI
  10.1016/j.jbiosc.2021.08.012
- NAID
  40022779634
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K12322, KAKENHI-PROJECT-20K20310
[Journal Article] APC/CCdh1 is required for the termination of chromosomal passenger complex activity upon mitotic exit2020
- Author(s)
  Tsunematsu Takaaki、Arakaki Rieko、Kawai Hidehiko、Ruppert Jan、Tsuneyama Koichi、Ishimaru Naozumi、Earnshaw William C.、Pagano Michele、Kudo Yasusei
- Journal Title
  
  Journal of Cell Science
  
  Volume: 133 Issue: 18 Pages: 251314-251314
- DOI
  10.1242/jcs.251314
- NAID
  120006937581
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K12322, KAKENHI-PROJECT-20K20310, KAKENHI-PROJECT-20K18480, KAKENHI-PROJECT-17H00785, KAKENHI-PROJECT-19H01070, KAKENHI-PROJECT-19H03853, KAKENHI-PROJECT-19K22718, KAKENHI-PROJECT-16H06276
[Journal Article] Single-stranded DNA versus tailed duplex in sequence conversion of lacZα DNA2020
- Author(s)
  Kawai Hidehiko、Sato Kento、Shirahama Wataru、Suzuki Tetsuya、Kamiya Hiroyuki
- Journal Title
  
  Nucleosides, Nucleotides & Nucleic Acids
  
  Volume: 39 Issue: 9 Pages: 1245-1250
- DOI
  10.1080/15257770.2020.1790596
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K12322, KAKENHI-PROJECT-20K20310, KAKENHI-PROJECT-17H00785
[Journal Article] Spironolactone-induced XPB degradation depends on CDK7 kinase and SCF<FBXL18> E3 ligase2019
- Author(s)
  Ueda, M., Matsuura, K., Kawai, H., Wakasugi, M. and Matsunaga, T.
- Journal Title
  
  Genes to Cells
  
  Volume: 24 Issue: 4 Pages: 284-296
- DOI
  10.1111/gtc.12674
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02952, KAKENHI-PROJECT-19K12319, KAKENHI-PROJECT-19K12322, KAKENHI-PROJECT-17H00785, KAKENHI-PROJECT-19H04265, KAKENHI-PROJECT-20K20310
[Journal Article] Preferential digestion of PCNA-ubiquitin and p53-ubiquitin linkages by USP7 to remove polyubiquitin chains from substrates2019
- Author(s)
  Masuda Y, Kanao R, Kawai H, Kukimoto I, Masutani C.
- Journal Title
  
  J Biol Chem.
  
  Volume: 294 Issue: 11 Pages: 4177-4187
- DOI
  10.1074/jbc.ra118.005167
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11309, KAKENHI-PROJECT-18K11638, KAKENHI-PROJECT-17H00785, KAKENHI-PROJECT-18H03371, KAKENHI-PROJECT-16K00547, KAKENHI-PROJECT-20K20310, KAKENHI-PROJECT-19K12322, KAKENHI-PROJECT-16H01775
[Journal Article] Stepwise multipolyubiquitination of p53 by the E6AP-E6 ubiquitin ligase complex2019
- Author(s)
  Masuda Y, Saeki Y, Arai N, Kawai H, Kukimoto I, Tanaka K, Masutani C.
- Journal Title
  
  J Biol Chem
  
  Volume: 294 Issue: 41 Pages: 14860-14875
- DOI
  10.1074/jbc.ra119.008374
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11309, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-16H01775, KAKENHI-PROJECT-17H00785, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-18H03371, KAKENHI-PROJECT-20K20310
[Journal Article] Replication stress induces accumulation of FANCD2 at central region of large fragile genes.2018
- Author(s)
  Okamoto Y, Iwasaki WM, Kugou K, Takahashi KK, Oda A, Sato K, Kobayashi W, Kawai H, Sakasai R, Takaori-Kondo A, Yamamoto T, Kanemaki MT, Taoka M, Isobe T, Kurumizaka H, Innan H, Ohta K, Ishiai M, Takata M.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 46(6) Issue: 6 Pages: 2932-2944
- DOI
  10.1093/nar/gky058
- NAID
  120006488604
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K00547, KAKENHI-PROJECT-26291018, KAKENHI-PLANNED-17H06380, KAKENHI-PLANNED-25116002, KAKENHI-PROJECT-15H01738, KAKENHI-PROJECT-17H01408, KAKENHI-PROJECT-16H07295, KAKENHI-PROJECT-16K15095, KAKENHI-PROJECT-15K16127, KAKENHI-PROJECT-18K11648, KAKENHI-PUBLICLY-18H04719, KAKENHI-PUBLICLY-18H05097, KAKENHI-PROJECT-17H00785, KAKENHI-PROJECT-18H02170, KAKENHI-PROJECT-15H04403, KAKENHI-PROJECT-20K20310, KAKENHI-PROJECT-17H03711, KAKENHI-PROJECT-16K18477
[Journal Article] Radiation-Induced Myofibroblasts Promote Tumor Growth via Mitochondrial ROS-Activated TGFβ Signaling.2018
- Author(s)
  Shimura T, Sasatani M, Kawai H, Kamiya K, Kobayashi J, Komatsu K, Kunugita N
- Journal Title
  
  Mol. Cancer Res.
  
  Volume: 16(11) Issue: 11 Pages: 1676-1686
- DOI
  10.1158/1541-7786.mcr-18-0321
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K00553, KAKENHI-PROJECT-17K19944, KAKENHI-PUBLICLY-18H04978, KAKENHI-PROJECT-17H00785, KAKENHI-PROJECT-18H03377, KAKENHI-PROJECT-16K00547, KAKENHI-PROJECT-20K20310
[Journal Article] Metabolomic screening using ESI-FT MS identifies potential radiation-responsive molecules in mouse urine.2017
- Author(s)
  Iizuka D, Yoshioka S, Kawai H, Izumi S, Suzuki F, Kamiya K.
- Journal Title
  
  J Radiat Res.
  
  Volume: in press Issue: 3 Pages: 273-280
- DOI
  10.1093/jrr/rrw112
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K00547, KAKENHI-PROJECT-17K01964
[Journal Article] Overexpression of Rev1 promotes the development of carcinogen-induced intestinal adenomas via accumulation of point mutation and suppression of apoptosis proportionally to the Rev1 expression level.2017
- Author(s)
  Sasatani M, Xi Y, Kajimura J, Kawamura T, Piao J, Masuda Y, Honda H, Kubo K, Mikamoto T, Watanabe H, Xu Y, Kawai H, Shimura T, Noda A, Hamasaki K, Kusunoki Y, Zaharieva EK, Kamiya K.
- Journal Title
  
  Carcinogenesis.
  
  Volume: 38(5) Issue: 5 Pages: 570-578
- DOI
  10.1093/carcin/bgw208
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K00547, KAKENHI-PROJECT-17K00553, KAKENHI-PROJECT-17K19944, KAKENHI-PROJECT-15H02818, KAKENHI-PROJECT-16K12594
[Journal Article] A comparison of radiation-induced mitochondrial damage between neural progenitor stem cells and differentiated cells.2017
- Author(s)
  Shimura T, Sasatani M, Kawai H, Kamiya K, Kobayashi J, Komatsu K, Kunugita N.
- Journal Title
  
  Cell Cycle.
  
  Volume: 16 Issue: 6 Pages: 565-573
- DOI
  10.1080/15384101.2017.1284716
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26241013, KAKENHI-PROJECT-15H02819, KAKENHI-PROJECT-15K12220, KAKENHI-PROJECT-16K00547
[Journal Article] ATM-mediated mitochondrial damage response triggered by nuclear DNA damage in normal human lung fibroblasts.2017
- Author(s)
  Shimura T, Sasatani M, Kawai H, Kamiya K, Kobayashi J, Komatsu K, Kunugita N.
- Journal Title
  
  Cell Cycle.
  
  Volume: 16(24) Issue: 24 Pages: 2345-2354
- DOI
  10.1080/15384101.2017.1387697
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K00547, KAKENHI-PROJECT-17K00553, KAKENHI-PROJECT-17K19944, KAKENHI-PROJECT-26241013, KAKENHI-PROJECT-15H02819, KAKENHI-PROJECT-17H00785, KAKENHI-PROJECT-20K20310
[Journal Article] 低線量放射線が着床前期胚の発生に与える影響2016
- Author(s)
  清水なつみ、河合秀彦、笹谷めぐみ、遠藤充浩、稲葉俊哉、神谷研二
- Journal Title
  
  長崎医学会雑誌
  
  Volume: 91 Pages: 290-292
- Data Source
  KAKENHI-PROJECT-16K00547
[Journal Article] Mitochondrial reactive oxygen species perturb AKT/cyclin D1 cell cycle signaling via oxidative inactivation of PP2A in low-dose irradiated human fibroblasts.2016
- Author(s)
  Shimura T, Sasatani M, Kamiya K, Kawai H, Inaba Y, Kunugita N.
- Journal Title
  
  Oncotarget
  
  Volume: 7 Issue: 3 Pages: 3559-70
- DOI
  10.18632/oncotarget.6518
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12220, KAKENHI-PROJECT-25340033, KAKENHI-PROJECT-25340032, KAKENHI-PROJECT-25281020
[Journal Article] ガンマ線持続照射環境での細胞運命制御メカニズムの解析2016
- Author(s)
  河合秀彦、曹麗麗、金井昭教、稲葉俊哉、神谷研二
- Journal Title
  
  長崎医学会雑誌
  
  Volume: 91 Pages: 193-196
- Data Source
  KAKENHI-PROJECT-16K00547
[Journal Article] Hepcidin-2 in mouse urine as a candidate radiation-responsive molecule.2016
- Author(s)
  Iizuka D, Yoshioka S, Kawai H, Okazaki E, Kiriyama K, Izumi S, Nishimura M, Shimada Y, Kamiya K, Suzuki F.
- Journal Title
  
  J Radiat Res
  
  Volume: 57(2) Issue: 2 Pages: 142-149
- DOI
  10.1093/jrr/rrv098
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25340033, KAKENHI-PROJECT-26340024, KAKENHI-PROJECT-15K12207
[Journal Article] A novel ATM/TP53/p21-mediated checkpoint only activated by chronic γ-irradiation2014
- Author(s)
  CAO Lili, KAWAI Hidehiko, SASATANI Megumi, IIZUKA Daisuke, MASUDA Yuji, INABA Toshiya, SUZUKI Keiji, OOTSUYAMA Akira, UMATA Toshiyuki, KAMIYA Kenji, SUZUKI Fumio
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 8 Pages: e104279-e104279
- DOI
  10.1371/journal.pone.0104279
- NAID
  120006986457
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24310040, KAKENHI-PROJECT-25281020, KAKENHI-PROJECT-25340032, KAKENHI-PROJECT-25340033, KAKENHI-PROJECT-25550031, KAKENHI-PROJECT-26293222, KAKENHI-PROJECT-26340024
[Journal Article] Selective enhancing effect of Early mitotic inhibitor 1 depletion on sensi tivity of doxorubicin.2013
- Author(s)
  Shimizu N, Nakajima NI, Tsunematsu T, Ogawa I, Kawai H, Hirayama R, Fujimori A, Yamada A, Okayasu R, Ishimaru N, Takata T, Kudo Y.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 288 Issue: 24 Pages: 17238-17252
- DOI
  10.1074/jbc.m112.446351
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J06562, KAKENHI-PROJECT-23689074, KAKENHI-PROJECT-24249067, KAKENHI-PROJECT-24689068, KAKENHI-PROJECT-25340033, KAKENHI-PROJECT-25670798
[Journal Article] Aberrant microRNA expression in radiation-induced rat mammary cancer: the potential role of miR-194 overexpression in cancer cell proliferation2013
- Author(s)
  Iizuka, D., Imaoka, T., Nishimura, M., Kawai, H., Suzuki, F., Shimada, Y.
- Journal Title
  
  Radiat Res.
  
  Volume: 179(2) Pages: 151-159
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710069
[Journal Article] Aberrant microRNA expression in radiation-induced rat mammary cancer: the potential role of miR-194 overexpression in cancer cell proliferation.2013
- Author(s)
  Iizuka D, Imaoka T, Nishimura M, Kawai H, Suzuki F, Shimada Y.
- Journal Title
  
  Radiat Res
  
  Volume: 179(2) Pages: 151-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710069
[Journal Article] Asymmetric nature of two subunits of RAD18, a RING-type ubiquitin ligase E3, in the human RAD6A-RAD18 ternary complex2012
- Author(s)
  Masuda, Y., Suzuki, M., Kawai, H., Suzuki, F., Kamiya, K.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 40(3) Pages: 1065-1076
- NAID
  120005147856
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710069
[Journal Article] En bloc transfer of polyubiquitin chains to PCNA in vitro is mediated by two different human E2-E3 pairs2012
- Author(s)
  Masuda, Y., Suzuki, M., Kawai, H., Hishiki, A., Hashimoto, H., Masutani, C., Hishida, T., Suzuki, F., Kamiya, K
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 40(20) Pages: 10394-10407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710069
[Journal Article] Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p732012
- Author(s)
  Katayama, H., Wang, J., Treekitkarnmongkol, W., Kawai, H., Sasai, K., Zhang, H., Wang, H., Adams, HP., Jiang, S., Chakraborty, SN., Suzuki, F., Arlinghaus, RB., Liu, J., Mobley, JA., Grizzle, WE., Wang, H., Sen, S.
- Journal Title
  
  Cancer Cell
  
  Volume: 21(2) Pages: 196-211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710069
[Journal Article] Aurora Kinase-A Inactivates DNA Damage-Induced Apoptosis and Spindle Assembly Checkpoint Response Functions of p73.2012
- Author(s)
  Katayama, H., Wang, J., Treekitkarnmongkol, W., Kawai, H., et al.
- Journal Title
  
  Cancer Cell.
  
  Volume: 21(2) Pages: 196-211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710069
[Journal Article] Asymmetric nature of two subunits of RAD18, a RING-type ubiquitin ligase E3, in the human RAD6A-RAD18 ternary complex.2012
- Author(s)
  Masuda, Y., Suzuki, M., Kawai, H., Suzuki, F., and Kamiya, K.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 40(3) Pages: 1065-1076
- NAID
  120005147856
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710069
[Journal Article] En bloc transfer of polyubiquitin chains to PCNA in vitro is mediated by two different human E2-E3 pairs.2012
- Author(s)
  Masuda Y, Suzuki M, Kawai H, Hishiki A, Hashimoto H, Masutani C, Hishida T, Suzuki F, Kamiya K.
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 40(20) Pages: 10394-407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710069
[Journal Article] The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo2011
- Author(s)
  Huang, L., Yan, Z., Liao, X., Li, Y., Yang, J., Wang, ZG., Zuo, Y., Kawai, H., Shadfan, M., Ganapathy, S., Yuan, ZM
- Journal Title
  
  Proc. Natl. Acad. Sci. U. S. A.
  
  Volume: 108(29) Pages: 12001-12006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710069
[Journal Article] The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo.2011
- Author(s)
  Huang, L., Yan, Z., Liao, X., Li, Y., Yang, J., Wang, ZG., Zuo, Y., Kawai, H., Shadfan, M., Ganapathy, S., and Yuan, ZM.
- Journal Title
  
  Proc. Natl. Acad. Sci. U. S. A.
  
  Volume: 108(29) Pages: 12001-12006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710069
[Journal Article] RING domain-mediated interaction is a requirement for MDM2's E3 ligase activity2007
- Author(s)
  Kawai, H., et. al.
- Journal Title
  
  Cancer Research 67
  
  Pages: 6026-6030
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17310035
[Journal Article] RING domain-mediated interaction is a requirement for MDM2's E3 ligase activity.2007
- Author(s)
  Kawai, H.
- Journal Title
  
  Cancer Research 67
  
  Pages: 6026-6030
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17310035
[Journal Article] RING domain-mediated interaction is a requirement for MDM2's E3 Ligase activity.2007
- Author(s)
  Kawai, Hidehiko
- Journal Title
  
  Cancer Research 67
  
  Pages: 6026-6030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18651024
[Journal Article] RING domain-mediated interaction is a requirement for MDM2's E3 Ligase activity.2007
- Author(s)
  Kawai, Hidehiko
- Journal Title
  
  Cancer Research 67
  
  Pages: 6026-6030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17310035
[Journal Article] Caspase-3 mediated cleavage or train m ionizing irradiated cells : Expression of the cleaved LyGDI induces cell death2006
- Author(s)
  Kawai, H., et. al.
- Journal Title
  
  Nagasaki Medical Journal 81
  
  Pages: 315-317
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17310035
[Journal Article] 電離放射線誘発細胞死シグナルにおける分断化LyGDIの機能解析.2006
- Author(s)
  河合, 秀彦
- Journal Title
  
  長崎医学会雑誌 81
  
  Pages: 315-317
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17310035
[Journal Article] 電離放射線誘発細胞死シグナルにおける分断化LyGDIめ機能解析2006
- Author(s)
  河合秀彦
- Journal Title
  
  長崎医学会雑誌 81 特集号
  
  Pages: 315-317
- Data Source
  KAKENHI-PROJECT-18651024
[Presentation] 遺伝子変異研究における新しい基盤技術の開発2024
- Author(s)
  河合秀彦
- Organizer
  第149回日本薬学会中国四国支部例会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K12375
[Presentation] Analysis of PCNA ubiquitination-dependent DNA damage tolerance in human cells2023
- Author(s)
  Rie Kanao, Hidehiko Kawai, Toshiyasu Taniguchi, Minoru Takata, Chikahide Masutani
- Organizer
  AT workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K12375
[Presentation] 酸化グアニンが誘発する遠隔作用変異におけるDNAグリコシラーゼNEIL1の役割2023
- Author(s)
  藤川芳宏，鈴木哲矢，河合秀彦，紙谷浩之
- Organizer
  日本放射線影響学会第66回大会
- Data Source
  KAKENHI-PROJECT-23K25005
[Presentation] 5’-tailed duplexes による複数の置換・欠失・挿入変異の遺伝子編集2023
- Author(s)
  天崎光、河合秀彦、佐藤健斗、加藤太樹、紙谷浩之
- Organizer
  日本環境変異原ゲノム学会第52回大会
- Data Source
  KAKENHI-PROJECT-22K12375
[Presentation] 酸化損傷塩基の修復に関わるDNAグリコシラーゼの遠隔作用変異における役割2023
- Author(s)
  藤川芳宏，鈴木哲矢，河合秀彦，紙谷浩之
- Organizer
  日本環境変異原ゲノム学会第52回大会
- Data Source
  KAKENHI-PROJECT-23K25005
[Presentation] 人工ヌクレアーゼを用いない遺伝編集ツール5’-tailed duplexの遺伝子編集能の配列依存性2023
- Author(s)
  加藤太樹、河合秀彦、紙谷浩之
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K12375
[Presentation] supF-NGS 法を用いたガンマ線照射の変異シグネチャー解析2023
- Author(s)
  岩田廉、河合秀彦、紙谷浩之
- Organizer
  日本環境変異原ゲノム学会第52回大会
- Data Source
  KAKENHI-PROJECT-22K12375
[Presentation] 酸化損傷塩基の修復に関わる DNA グリコシラーゼの遠隔作用変異における役割2023
- Author(s)
  藤川芳宏、鈴木哲矢、河合秀彦、紙谷浩之
- Organizer
  日本環境変異原ゲノム学会第52回大会
- Data Source
  KAKENHI-PROJECT-22K12375
[Presentation] 酸化グアニンが誘発する遠隔作用変異におけるDNAグリコシラーゼNEIL1の役割2023
- Author(s)
  藤川芳宏、鈴木哲矢、河合秀彦、紙谷浩之
- Organizer
  日本放射線影響学会第66回大会
- Data Source
  KAKENHI-PROJECT-22K12375
[Presentation] 人工ヌクレアーゼを用いない遺伝子編集：様々な遺伝子配列の編集効率2023
- Author(s)
  紙谷浩之、加藤太樹、河合秀彦
- Organizer
  日本分析化学会第72回年会
- Data Source
  KAKENHI-PROJECT-22K12375
[Presentation] 次世代シークエンサーを用いたsupF遺伝子変異解析系の開発2022
- Author(s)
  増田翔吾, 岩田廉, 海老駿吾, 河合秀彦, 紙谷浩之
- Organizer
  第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-22K12375
[Presentation] 8-Oxo-7,8-dihydroguanineの遠隔作用変異へのNEIL1及びNTH1のノックダウンの影響2022
- Author(s)
  藤川芳宏、鈴木哲矢，河合秀彦，紙谷浩之
- Organizer
  日本環境変異原ゲノム学会第51回大会
- Data Source
  KAKENHI-PROJECT-23K25005
[Presentation] supF 遺伝子と Next Generation Sequencer を用いたハイスループット変異解析法の開発2022
- Author(s)
  岩田廉, 河合秀彦, 紙谷浩之
- Organizer
  日本環境変異原ゲノム学会第51回大会
- Data Source
  KAKENHI-PROJECT-22K12375
[Presentation] Shuttle Vector NGS 変異解析法による遠隔作用変異誘発機構解析2022
- Author(s)
  藤原千穂, 海老駿吾, 河合秀彦, 紙谷浩之
- Organizer
  第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-22K12375
[Presentation] RFWD3 and TLS polymerases play crucial roles in PCNA ubiquitination-dependent DNA damage tolerance in human cells2022
- Author(s)
  Rie Kanao, Hidehiko Kawai, Toshiyasu Taniguchi, Minoru Takata, Chikahide Masutani
- Organizer
  Meeting on Endogenous DNA Damage and Repair
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K12375
[Presentation] 8-Oxo-7,8-dihydroguanine の遠隔作用変異への NEIL1 及び NTH1 のノックダウンの影響2022
- Author(s)
  藤川芳宏 , 鈴木哲矢 , 河合秀彦 , 紙谷浩之
- Organizer
  日本環境変異原ゲノム学会第51回大会
- Data Source
  KAKENHI-PROJECT-22K12375
[Presentation] 人工ヌクレアーゼを用いない遺伝編集ツール5'-tailed duplexの遺伝子編集能の向上2022
- Author(s)
  上坪諒太郎, 河合秀彦, 紙谷浩之
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K12375
[Presentation] 人工ヌクレアーゼを用いない遺伝子編集ツールTailed Duplexにおける配列依存性の検討2022
- Author(s)
  上坪諒太郎, 河合秀彦, 紙谷浩之
- Organizer
  第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-22K12375
[Presentation] DDX41変異によるR-loop増加を介した細胞増殖障害2022
- Author(s)
  神力悟, 平山真弓, トンガラグ・サロール, 長町安希子, 金井昭教, 片岡直行, 河合秀彦, 横山明彦, 稲葉俊哉, 松井啓隆
- Organizer
  第84回日本血液学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K12375
[Presentation] RFWD3 mediates a crucial pathway of PCNA ubiquitination-dependent DNA damage tolerance in human cells2022
- Author(s)
  Rie Kanao, Hidehiko Kawai, Toshiyasu Taniguchi, Minoru Takata, Chikahide Masutani
- Organizer
  遺伝研国際シンポジウム2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K12375
[Presentation] ヒト細胞においてRFWD3はPCNAの翻訳後修飾依存的なDNA損傷トレランスに関与する2022
- Author(s)
  金尾梨絵, 河合秀彦, 谷口俊恭, 高田穣, 益谷央豪
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K12375
[Presentation] NGSと低線量率放射線環境を用いた遠隔作用変異の分子機構解析2021
- Author(s)
  海老駿吾、河合秀彦、紙谷浩之
- Organizer
  日本環境変異原ゲノム学会第50回記念大会
- Data Source
  KAKENHI-PROJECT-19K12322
[Presentation] プロテオーム解析による放射線被ばくのマウス尿中バイオマーカー探索2021
- Author(s)
  飯塚大輔、泉俊輔、河合秀彦、神谷研二、鈴木文男
- Organizer
  日本放射線影響学会第 64 回大会
- Data Source
  KAKENHI-PROJECT-19K12322
[Presentation] 次世代シークエンサーを用いたsupF遺伝子変異解析系の開発2021
- Author(s)
  増田翔吾、鈴木哲矢、河合秀彦、紙谷浩之
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19H04278
[Presentation] NGSと低線量率放射線環境を用いた遠隔作用変異の分子機構解2021
- Author(s)
  海老駿吾、河合秀彦、紙谷浩之
- Organizer
  日本環境変異原ゲノム学会第50回記念大会
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] PCNA のユビキチン化によって制御されるヒト細胞の新規 DNA 損傷トレランス経路の検出2021
- Author(s)
  益谷央豪、金尾梨絵、河合秀彦、谷口俊恭、髙田穣
- Organizer
  日本放射線影響学会第 64 回大会放生研シンポジウム
- Data Source
  KAKENHI-PROJECT-19K12322
[Presentation] 変異シグネチャー解析による8-hydroxyguanineにより誘発される遠隔作用変異誘発機構の解明2021
- Author(s)
  福島瑠里子、鈴木哲矢、河合秀彦、紙谷浩之
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19H04278
[Presentation] 人工ヌクレアーゼを用いない遺伝子編集ツールTailed Duplexの編集効率の向上2021
- Author(s)
  上坪諒太郎、佐藤健斗、矢間顕太郎、河合秀彦、紙谷浩之
- Organizer
  日本核酸医薬学会第６回年会
- Data Source
  KAKENHI-PROJECT-19K12322
[Presentation] ヒト細胞においてRFWD3はPCNAの翻訳後修飾依存的なDNA損傷トレランスに関与する2021
- Author(s)
  金尾梨絵、河合秀彦、谷口俊恭、高田穣、益谷央豪
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K12322
[Presentation] 変異シグネチャー解析による8-hydroxyguanineにより誘発される遠隔作用変異誘発機構の解明2021
- Author(s)
  福島瑠里子、鈴木哲矢、河合秀彦、紙谷浩之
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K12322
[Presentation] 人工ヌクレアーゼを用いない遺伝子編集ツールTailed Duplexにおける配列依存性の検討2021
- Author(s)
  上坪諒太郎、佐藤健斗、矢間顕太郎、河合秀彦、紙谷浩之
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K12322
[Presentation] DNA損傷に対するp53依存的、非依存的な細胞応答によるiPS細胞のゲノム安定性維持機構2021
- Author(s)
  杉原竜誠、河合秀彦、紙谷浩之
- Organizer
  日本環境変異原ゲノム学会第50回記念大会
- Data Source
  KAKENHI-PROJECT-19K12322
[Presentation] DNA損傷に対するp53依存的、非依存的な細胞応答によるiPS細胞のゲノム安定性維持機構2021
- Author(s)
  杉原竜誠、河合秀彦、紙谷浩之
- Organizer
  日本環境変異原ゲノム学会第50回記念大会
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] 次世代シークエンサーを用いたsupF遺伝子変異解析系の開発2021
- Author(s)
  増田翔吾、鈴木哲矢、河合秀彦、紙谷浩之
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K12322
[Presentation] 8-Oxo-7,8-dihydroguanine (8-hydroxyguanine) による遠隔作用変異誘発へのOGG1とWRNのダブルノックダウンの影響2020
- Author(s)
  財間悠大、鈴木哲矢、河合秀彦、紙谷浩之
- Organizer
  日本環境変異原学会第49回大会
- Data Source
  KAKENHI-PROJECT-19H04278
[Presentation] 8-dihydroguanine による遠隔作用変異誘発への OGG1 と WRN のダブルノックダウンの影響の解析2020
- Author(s)
  財間悠大、鈴木哲矢、河合秀彦、紙谷浩之
- Organizer
  日本環境変異原学会第49回大会（沼津）
- Data Source
  KAKENHI-PROJECT-19K12322
[Presentation] 人工ヌクレアーゼを用いない遺伝子編集2020
- Author(s)
  矢間顕太郎、鈴木哲矢、河合秀彦、紙谷浩之
- Organizer
  日本薬学会第140年会（京都）(中止）
- Data Source
  KAKENHI-PROJECT-19K12322
[Presentation] 人工ヌクレアーゼを用いない遺伝子編集法の開発：ミスマッチ塩基数の影響2020
- Author(s)
  佐藤健斗、矢間顕太郎、河合秀彦、紙谷浩之
- Organizer
  日本環境変異原学会第49回大会（沼津）
- Data Source
  KAKENHI-PROJECT-19K12322
[Presentation] supF遺伝子変異解析のための新規大腸菌株の作製2020
- Author(s)
  福島瑠里子、河合秀彦、鈴木哲矢、紙谷浩之
- Organizer
  日本薬学会第140年会（京都）(中止）
- Data Source
  KAKENHI-PROJECT-19K12322
[Presentation] supF遺伝子変異解析のための新規大腸菌株の作製2020
- Author(s)
  福島瑠里子，鈴木哲矢，河合秀彦，紙谷浩之
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19H04278
[Presentation] Apc Min/+マウスを用いた放射線誘発腫瘍における遺伝子変異解析2019
- Author(s)
  笹谷めぐみ, 飯塚大輔, 河合秀彦, Zaharieva Elena, 神谷研二
- Organizer
  第6回アジア環境変異原学会／日本環境変異原学会第48回大会合同大会
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] 核酸のみで行うゲノム編集法確立に向けた high throughput 解析法2019
- Author(s)
  紙谷浩之, 柳井優里，鈴木哲矢，河合秀彦
- Organizer
  第79回分析化学討論会
- Data Source
  KAKENHI-PROJECT-19K12322
[Presentation] DNA 損傷による細胞運命決定での MDM2-MDMX を介した TP53 の発現変動の役割2019
- Author(s)
  河合秀彦 , 紙谷浩之
- Organizer
  第6回アジア環境変異原学会／日本環境変異原学会第48回大会合同大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] 染色体パッセンジャー複合体による多能性幹細胞の未分化能維持機構2019
- Author(s)
  常松貴明, 河合秀彦, 石丸直澄, William C. Earnshaw, Michele Pagano, 工藤保誠
- Organizer
  第36回染色体ワークショップ
- Data Source
  KAKENHI-PROJECT-16H05542
[Presentation] 放射線が着床前期胚に与える影響2019
- Author(s)
  金井昭教、清水なつみ、長町安希子、河合秀彦、稲葉俊哉
- Organizer
  日本放射線影響学会第62回大会
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] Apc Min/+マウスを用いた放射線誘発腫瘍における遺伝子変異解析2019
- Author(s)
  笹谷めぐみ, 飯塚大輔, 河合秀彦, Zaharieva Elena, 神谷研二
- Organizer
  第6回アジア環境変異原学会／日本環境変異原学会第48回大会合同大会
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] 放射線が着床前期胚に与える影響2019
- Author(s)
  金井昭教、清水なつみ、長町安希子、河合秀彦、稲葉俊哉
- Organizer
  日本放射線影響学会第62回大会
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] DNA 損傷による細胞運命決定での MDM2-MDMX を介した TP53 の発現変動の役割2019
- Author(s)
  河合秀彦 , 紙谷浩之
- Organizer
  第6回アジア環境変異原学会／日本環境変異原学会第48回大会合同大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K12322
[Presentation] Apc Min/+マウスを用いた放射線誘発腫瘍における遺伝子変異解析2019
- Author(s)
  笹谷めぐみ, 飯塚大輔, 河合秀彦, Zaharieva Elena, 神谷研二
- Organizer
  日本環境変異原学会第47回大会
- Data Source
  KAKENHI-PROJECT-17K00553
[Presentation] Estimation of radiation-induced cancer risk at low doses and low dose rates using ApcMin/+ mice2019
- Author(s)
  Megumi Sasatani, Daisuke Iizuka, Hidehiko Kawai, Elena Zaharieva, Kenji Kamiya
- Organizer
  3rd International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] 人工ヌクレアーゼを用いない遺伝子編集：一本鎖DNAとTailed Duplexの比較2019
- Author(s)
  佐藤健斗, 鈴木哲矢, 河合秀彦, 紙谷浩之
- Organizer
  第 42 回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K12322
[Presentation] Estimation of radiation-induced cancer risk at low doses and low dose rates using ApcMin/+ mice2019
- Author(s)
  Megumi Sasatani, Daisuke Iizuka, Hidehiko Kawai, Elena Zaharieva, Kenji Kamiya,
- Organizer
  3rd International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science
- Data Source
  KAKENHI-PROJECT-17K00553
[Presentation] 人工ヌクレアーゼを用いない遺伝子編集：蛍光タンパク質を用いたハイスループットアッセイ系の確立2019
- Author(s)
  矢間顕太郎, 鈴木哲矢, 河合秀彦, 紙谷浩之
- Organizer
  第 42 回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K12322
[Presentation] 放射線が着床前期胚に与える影響2019
- Author(s)
  金井昭教、清水なつみ、長町安希子、河合秀彦、稲葉俊哉
- Organizer
  日本放射線影響学会第62回大会
- Data Source
  KAKENHI-PROJECT-19K12322
[Presentation] Estimation of radiation-induced cancer risk at low doses and low dose rates using ApcMin/+ mice2019
- Author(s)
  Megumi Sasatani, Daisuke Iizuka, Hidehiko Kawai, Elena Zaharieva, Kenji Kamiya
- Organizer
  3rd International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] DNA 損傷による細胞運命決定での MDM2-MDMX を介した TP53 の発現変動の役割2019
- Author(s)
  河合秀彦 , 紙谷浩之
- Organizer
  第6回アジア環境変異原学会／日本環境変異原学会第48回大会合同大会
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] Apc Min/+マウスを用いた放射線誘発腫瘍における遺伝子変異解析2019
- Author(s)
  笹谷めぐみ, 飯塚大輔, 河合秀彦, Zaharieva Elena, 神谷研二
- Organizer
  第6回アジア環境変異原学会／日本環境変異原学会第48回大会合同大会
- Data Source
  KAKENHI-PROJECT-17K00553
[Presentation] The role of fibroblasts in tumor microenvironment formation associated with radiation-induced cancer.2019
- Author(s)
  Tsutomu Shimura, Megumi Sasatani, Hidehiko Kawai, Kenji Kamiya, Akira Ushiyama
- Organizer
  Joint type-Network the of Symposium International 4th T
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K12322
[Presentation] Tailed duplex による培養細胞でのゲノム編集：染色体上 copepod GFP 遺伝子の修復2019
- Author(s)
  紙谷浩之, 河合秀彦，柳井優里，鈴木哲矢
- Organizer
  日本ゲノム編集学会第4回大会
- Data Source
  KAKENHI-PROJECT-19K12322
[Presentation] Apc Min/+ マウスを用いた放射線誘発腫瘍における遺伝子変異解析2018
- Author(s)
  笹谷めぐみ, 飯塚大輔, 河合秀彦, ザハリエバエレナ, 神谷研二
- Organizer
  日本環境変異原学会第47回大会
- Data Source
  KAKENHI-PROJECT-16K00547
[Presentation] 持続的DNA損傷に対する細胞応答の解析2018
- Author(s)
  河合秀彦, 笹谷めぐみ, ザハリエバエレナ, 紙谷浩之, 神谷研二
- Organizer
  日本環境変異原学会第47回大会
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] 持続的 DNA 損傷に対する細胞応答の解析2018
- Author(s)
  河合秀彦, 笹谷めぐみ, ザハリエバエレナ, 紙谷浩之, 神谷研二
- Organizer
  日本環境変異原学会第47回大会
- Data Source
  KAKENHI-PROJECT-16K00547
[Presentation] 持続的DNA損傷に対する細胞応答の解析2018
- Author(s)
  河合秀彦, 笹谷めぐみ, ザハリエバエレナ, 紙谷浩之, 神谷研二
- Organizer
  日本環境変異原学会第47回大会
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] TP53制御と細胞運命決定2018
- Author(s)
  河合秀彦、佐藤健一、紙谷浩之
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] Apc Min/+マウスを用いた放射線誘発腫瘍における遺伝子変異解析2018
- Author(s)
  笹谷めぐみ, 飯塚大輔, 河合秀彦, Zaharieva Elena, 神谷研二
- Organizer
  日本環境変異原学会第47回大会
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] 次世代シーケンサを用いた低線量放射線影響研究2018
- Author(s)
  金井　昭教、清水　なつみ、長町　安希子、河合　秀彦、稲葉　俊哉
- Organizer
  日本放射線影響学会61回大会
- Data Source
  KAKENHI-PROJECT-16K00547
[Presentation] TP53制御と細胞運命決定2018
- Author(s)
  河合秀彦、佐藤健一、紙谷浩之
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] 次世代シーケンサを用いた低線量放射線影響研究2018
- Author(s)
  金井　昭教、清水　なつみ、長町　安希子、河合　秀彦、稲葉　俊哉
- Organizer
  日本放射線影響学会61回大会
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] TP53制御と細胞運命決定2018
- Author(s)
  河合秀彦、佐藤健一、紙谷浩之
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K00547
[Presentation] 放射線誘発がん関連繊維芽細胞は、活性酸素によるTGFβシグナリング経路の活性化を介してがんの増殖を促進する2018
- Author(s)
  志村勉, 笹谷めぐみ, 河合秀彦, 神谷研二, 小林純也, 小松賢志, 欅田尚樹
- Organizer
  日本放射線影響学会第61回大会
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] TP53制御と細胞運命決定2018
- Author(s)
  河合秀彦、佐藤健一、紙谷浩之
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] 放射線誘発がん関連繊維芽細胞は、活性酸素によるTGFβシグナリング経路の活性化を介してがんの増殖を促進する2018
- Author(s)
  志村勉, 笹谷めぐみ, 河合秀彦, 神谷研二, 小林純也, 小松賢志, 欅田尚樹
- Organizer
  日本放射線影響学会第61回大会
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] 次世代シーケンサを用いた低線量放射線影響研究2018
- Author(s)
  金井　昭教、清水　なつみ、長町　安希子、河合　秀彦、稲葉　俊哉
- Organizer
  日本放射線影響学会61回大会
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] Apc Min/+マウスを用いた放射線誘発腫瘍における遺伝子変異解析2018
- Author(s)
  笹谷めぐみ, 飯塚大輔, 河合秀彦, Zaharieva Elena, 神谷研二
- Organizer
  日本環境変異原学会第47回大会
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] 次世代シーケンサを用いた低線量放射線影響研究2018
- Author(s)
  金井昭教、清水なつみ、長町安希子、河合秀彦、稲葉俊哉
- Organizer
  日本放射線影響学会61回大会
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] 放射線誘発がん関連線維芽細胞は、活性酸素によるTGFβシグナリング経路の活性化を介してがんの増殖を促進する2018
- Author(s)
  志村　勉、笹谷　めぐみ、河合　秀彦、神谷　研二、小林　純也、小松　賢志、欅田　尚樹
- Organizer
  日本放射線影響学会61回大会
- Data Source
  KAKENHI-PROJECT-16K00547
[Presentation] ApcMin/+マウスを用いた低線量、低線量率放射線発がんリスク評価の試みとその腫瘍解析2017
- Author(s)
  笹谷めぐみ, 飯塚大輔, 河合秀彦, Elena　Zaharieva, 神谷研二
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] Inflammatory response in primary human endothelial cells subjected to acute or protracted gamma irradiation2017
- Author(s)
  Zaharieva E, Kawai H, Inaba T, Matsuura S, Kamiya K
- Organizer
  第58回原爆後障害研究会
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] Apc Min/+マウスを用いた低線量、低線量率放射線発がんリスク評価2017
- Author(s)
  笹谷　めぐみ、飯塚　大輔、河合　秀彦、Zaharieva Elena、神谷　研二
- Organizer
  第60回日本放射線影響学会
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] 持続的なDNA損傷による生物影響の網羅的解析研究2017
- Author(s)
  河合秀彦、笹谷めぐみ、ザハリエバエレナ、紙谷浩之、神谷研二
- Organizer
  日本環境変異原学会第46回大会
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] 持続放射線照射環境を用いた細胞老化の分子機構解析2017
- Author(s)
  河合秀彦, 笹谷めぐみ, 金井昭教, 稲葉俊哉, 神谷研二,
- Organizer
  2017年度生命科学系学会合同年次大会,
- Data Source
  KAKENHI-PROJECT-16K00547
[Presentation] 遺伝的背景が放射線発がん高感受性モデルマウスの腫瘍形成に与える影響について2017
- Author(s)
  笹谷めぐみ, 飯塚大輔, 河合秀彦, Zaharieva Elena, 神谷研二
- Organizer
  第58回原子爆弾後障害研究会
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] Apc Min/+マウスを用いた放射線誘発腫瘍における遺伝子変異の検出2017
- Author(s)
  笹谷めぐみ、飯塚大輔、河合秀彦、Zaharieva Elena、神谷研二
- Organizer
  日本環境変異原学会第46回大会
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] Apc Min/+マウスを用いた放射線誘発腫瘍における遺伝子変異の検出.2017
- Author(s)
  笹谷めぐみ、飯塚大輔、河合秀彦、Zaharieva Elena、神谷研二
- Organizer
  日本環境変異原学会第46回大会
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] Analysis of radiation induced mutations using next generation sequencer2017
- Author(s)
  Akinori Kanai, Akiko Nagamachi, Hidehiko Kawai, Hirotaka Matsui, Kenji Kamiya, Toshiya Inaba
- Organizer
  The 1st International Symposium of the network-type joint Usage/Research Center for Radiation Disaster Medical Science
- Place of Presentation
  広島市
- Year and Date
  2017-02-21
- Data Source
  KAKENHI-PROJECT-16K00547
[Presentation] 放射線発がん高感受性マウスを用いた低線量・低線量率発がんリスク評価2017
- Author(s)
  笹谷めぐみ, 飯塚大輔, 河合秀彦, Zaharieva Elena, 神谷研二
- Organizer
  第2回放射線災害・医科学研究拠点カンファランス
- Data Source
  KAKENHI-PROJECT-17K00553
[Presentation] 異なる線量率の持続放射線照射を用いた放射線生物学2017
- Author(s)
  河合秀彦
- Organizer
  第58回原爆後障害研究会
- Invited
- Data Source
  KAKENHI-PROJECT-16K00547
[Presentation] 持続的なDNA損傷による生物影響の網羅的解析研究2017
- Author(s)
  河合秀彦、笹谷めぐみ、ザハリエバエレナ、紙谷浩之、神谷研二
- Organizer
  日本環境変異原学会第46回大会
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] ApcMin/+マウスを用いた低線量、低線量率放射線発がんリスク評価の試みとその腫瘍解析2017
- Author(s)
  笹谷めぐみ, 飯塚大輔, 河合秀彦, Elena　Zaharieva, 神谷研二
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] A comparison of radiation-induced mitochondrial damage between neural progenitor stem cells and differentiated cells2017
- Author(s)
  Tsutomu Shimura, Megumi Sasatani, Hidehiko Kawai, Kenji Kamiya, Naoki Kunugida
- Organizer
  The 1st International Symposium of the network-type joint Usage/Research Center for Radiation Disaster Medical Science
- Place of Presentation
  広島市
- Year and Date
  2017-02-21
- Data Source
  KAKENHI-PROJECT-16K00547
[Presentation] 遺伝的背景が放射線発がん高感受性モデルマウスの腫瘍形成に与える影響について2017
- Author(s)
  笹谷めぐみ, 飯塚大輔, 河合秀彦, Zaharieva Elena, 神谷研二
- Organizer
  第58回原子爆弾後障害研究会
- Data Source
  KAKENHI-PROJECT-17K00553
[Presentation] ガンマ線持続照射環境を用いた細胞運命制御メカニズムの解析2017
- Author(s)
  河合秀彦、曹麗麗、笹谷めぐみ、ザハリエバエレナ、金井昭教、稲葉俊哉、神谷研二
- Organizer
  第60回日本放射線影響学会
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] 異なる線量率の持続放射線照射を用いた放射線生物学2017
- Author(s)
  河合秀彦
- Organizer
  第58回原爆後障害研究会
- Invited
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] マウス個体を用いた低線量率放射線被ばくの生物影響について2017
- Author(s)
  笹谷　めぐみ、飯塚　大輔、河合　秀彦、Zaharieva Elena、神谷　研二
- Organizer
  第42回中国地区放射線影響研究会
- Data Source
  KAKENHI-PROJECT-17K00553
[Presentation] ガンマ線持続照射環境を用いた細胞運命制御メカニズムの解析2017
- Author(s)
  河合秀彦、曹麗麗、笹谷めぐみ、ザハリエバエレナ、金井昭教、稲葉俊哉、神谷研二
- Organizer
  第60回日本放射線影響学会
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] 持続的なDNA損傷による生物影響の網羅的解析研究2017
- Author(s)
  河合秀彦、笹谷めぐみ、ザハリエバエレナ、紙谷浩之、神谷研二
- Organizer
  日本環境変異原学会第46回大会
- Data Source
  KAKENHI-PROJECT-16K00547
[Presentation] ガンマ線持続照射環境を用いた細胞運命制御メカニズムの解析2017
- Author(s)
  河合秀彦、曹麗麗、笹谷めぐみ、ザハリエバエレナ、金井昭教、稲葉俊哉、神谷研二
- Organizer
  第60回日本放射線影響学会,
- Data Source
  KAKENHI-PROJECT-16K00547
[Presentation] Apc Min/+マウスを用いた低線量、低線量率放射線発がんリスク評価2017
- Author(s)
  笹谷　めぐみ、飯塚　大輔、河合　秀彦、Zaharieva Elena、神谷　研二
- Organizer
  第60回日本放射線影響学会
- Data Source
  KAKENHI-PROJECT-17K00553
[Presentation] Apc Min/+マウスを用いた放射線誘発腫瘍における遺伝子変異の検出2017
- Author(s)
  笹谷　めぐみ、飯塚　大輔、河合　秀彦、Zaharieva Elena、神谷　研二
- Organizer
  日本環境変異原学会第46回大会
- Data Source
  KAKENHI-PROJECT-17K00553
[Presentation] ApcMin/+マウスを用いた低線量、低線量率放射線発がんリスク評価の試みとその腫瘍解析2017
- Author(s)
  笹谷めぐみ, 飯塚大輔, 河合秀彦, Elena　Zaharieva, 神谷研二
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K00553
[Presentation] Mammary microenvironment is important for the increase of stem cells frequency by radiation exposure2017
- Author(s)
  Daisuke Iizuka, Megumi Sasatani, Hidehiko Kawai, Kenji Kamiya
- Organizer
  The 1st International Symposium of the network-type joint Usage/Research Center for Radiation Disaster Medical Science
- Place of Presentation
  広島市
- Year and Date
  2017-02-21
- Data Source
  KAKENHI-PROJECT-16K00547
[Presentation] Biological effects of low-dose radiation on cells and their implications in cancer risk2017
- Author(s)
  河合秀彦
- Organizer
  Consultancy Meeting on Science, Technology and Society Perspectives on Nuclear Science, Radiation and Human Health - The International Perspective
- Invited
- Data Source
  KAKENHI-PROJECT-16K00547
[Presentation] 持続放射線照射環境を用いた細胞老化の分子機構解析2017
- Author(s)
  河合秀彦, 笹谷めぐみ, 金井昭教, 稲葉俊哉, 神谷研二
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17H00785
[Presentation] マウス個体を用いた低線量率放射線被ばくの生物影響について2017
- Author(s)
  笹谷めぐみ、飯塚大輔、河合秀彦、Zaharieva Elena、神谷研二
- Organizer
  第42回中国地区放射線影響研究会
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] Apc Min/+マウスを用いた低線量、低線量率放射線発がんリスク評価2017
- Author(s)
  笹谷めぐみ、飯塚大輔、河合秀彦、Zaharieva Elena、神谷研二
- Organizer
  第60回日本放射線影響学会
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] Biological effects of low-dose radiation on cells and their implications in cancer risk2017
- Author(s)
  河合秀彦
- Organizer
  Consultancy Meeting on Science, Technology and Society Perspectives on Nuclear Science, Radiation and Human Health - The International Perspective
- Invited
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] Inflammatory response to acute and chronic gamma irradiation in primary human endothelial cells.2017
- Author(s)
  Elena Zaharieva, Hidehiko Kawai, Megumi Sasatani, Toshiya Inaba, Shinya Matsuura, Kenji Kamiya
- Organizer
  第60回日本放射線影響学会
- Data Source
  KAKENHI-PROJECT-20K20310
[Presentation] DNA end resectionの誘発と細胞の応答2016
- Author(s)
  矢島浩彦、劉翠華、薛蓮、中島菜花子、河合秀彦
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜市
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K00547
[Presentation] 次世代シーケンサーを用いた放射線誘発変異解析2016
- Author(s)
  金井昭教、長町安希子、河合秀彦、松井啓隆、神谷研二、稲葉俊哉
- Organizer
  第59回日本放射線影響学会
- Place of Presentation
  広島市
- Year and Date
  2016-10-27
- Data Source
  KAKENHI-PROJECT-16K00547
[Presentation] 低線量放射線が着床前期胚の発生に与える影響2016
- Author(s)
  清水なつみ、河合秀彦、笹谷めぐみ、遠藤充浩、稲葉俊哉、神谷研二
- Organizer
  第57回原子爆弾後障害研究会
- Place of Presentation
  長崎市
- Year and Date
  2016-06-05
- Data Source
  KAKENHI-PROJECT-16K00547
[Presentation] Inflammatory response in primary human endothelial cells subjected to gamma irradiation at different dose rates2016
- Author(s)
  Zaharieva Elena、河合秀彦、稲葉俊哉、松浦伸也、神谷研二
- Organizer
  第59回日本放射線影響学会
- Place of Presentation
  広島市
- Year and Date
  2016-10-28
- Data Source
  KAKENHI-PROJECT-16K00547
[Presentation] ガンマ線持続照射環境での細胞運命制御メカニズムの解析2016
- Author(s)
  河合秀彦、曹麗麗、金井昭教、稲葉俊哉、神谷研二
- Organizer
  第57回原子爆弾後障害研究会
- Place of Presentation
  長崎市
- Year and Date
  2016-06-05
- Data Source
  KAKENHI-PROJECT-16K00547
[Presentation] ApcMin/+マウスを用いた放射線発がんにおける線量率効果と遺伝的背景が及ぼす影響について2016
- Author(s)
  笹谷めぐみ、飯塚大輔、河合秀彦、神谷研二
- Organizer
  第41回中国地区放射線影響研究会
- Place of Presentation
  広島市
- Year and Date
  2016-07-26
- Data Source
  KAKENHI-PROJECT-16K00547
[Presentation] 低線量放射線による着床前期胚の発生抑制メカニズム2016
- Author(s)
  清水なつみ、河合秀彦、笹谷めぐみ、遠藤充浩、稲葉俊哉、神谷研二
- Organizer
  第59回日本放射線影響学会
- Place of Presentation
  広島市
- Year and Date
  2016-10-28
- Data Source
  KAKENHI-PROJECT-16K00547
[Presentation] 低線量被ばくによる乳腺幹細胞頻度の増加に関与する遺伝子群の同定2016
- Author(s)
  飯塚大輔、笹谷めぐみ、河合秀彦、神谷研二
- Organizer
  第59回日本放射線影響学会
- Place of Presentation
  広島市
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-16K00547
[Presentation] ガンマ線持続照射による細胞老化の分子機構解析2016
- Author(s)
  河合秀彦、曹麗麗、金井昭教、笹谷めぐみ、飯塚大輔、ザハリエバエレナ、稲葉俊哉、神谷研二
- Organizer
  第59回日本放射線影響学会
- Place of Presentation
  広島市
- Year and Date
  2016-10-27
- Data Source
  KAKENHI-PROJECT-16K00547
[Presentation] Apcmin/+ マウスを用いた放射線発がんにおける線量率効果2016
- Author(s)
  笹谷めぐみ、飯塚大輔、河合秀彦、神谷研二
- Organizer
  第59回日本放射線影響学会
- Place of Presentation
  広島市
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-16K00547
[Presentation] NER阻害化合物A6のERCC1-XPF分解誘導メカニズムの解析2016
- Author(s)
  小田桐周平、三島観知、若杉光生、上田将信、川原弘明、西永真理、河合秀彦、長田裕之、松永司
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜市
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K00547
[Presentation] 放射線被ばくによる乳腺幹細胞への影響解析―低線量被ばくでの乳腺幹細胞頻度の増加には系統差が見られる―2016
- Author(s)
  飯塚大輔、笹谷めぐみ、河合秀彦、神谷研二
- Organizer
  第41回中国地区放射線影響研究会
- Place of Presentation
  広島市
- Year and Date
  2016-07-26
- Data Source
  KAKENHI-PROJECT-16K00547
[Presentation] 過酸化水素によるTGF-bを介した上皮間葉転換促進メカニズム2016
- Author(s)
  飯塚大輔、笹谷めぐみ、河合秀彦、神谷研二
- Organizer
  第159回日本獣医学会
- Place of Presentation
  神奈川県藤沢市
- Year and Date
  2016-09-06
- Data Source
  KAKENHI-PROJECT-16K00547
[Presentation] DNA 二本鎖切断の修復経路選択と細胞応答2016
- Author(s)
  矢島浩彦、劉翠華、薛蓮、中島菜花子、河合秀彦
- Organizer
  第59回日本放射線影響学会
- Place of Presentation
  広島市
- Year and Date
  2016-10-27
- Data Source
  KAKENHI-PROJECT-16K00547
[Presentation] 人工多能性幹細胞（iPS 細胞）の放射線高感受性における DNA 損傷応答の役割2016
- Author(s)
  嶋本顕、香川晴信、加藤尚也、河合秀彦、佐久間哲史、山本卓、塩谷文章、田原栄俊
- Organizer
  第59回日本放射線影響学会
- Place of Presentation
  広島市
- Year and Date
  2016-10-27
- Data Source
  KAKENHI-PROJECT-16K00547
[Presentation] Mechanism of Multiple Lysine 48-linked Ubiquitin Chain Synthesis by E6AP2016
- Author(s)
  Yuji Masuda, Yasushi Saeki, Saeko Yanaka, Hidehiko Kawai, Iwao Kukimoto, Koichi Kato, Keiji Tanaka, Chikahide Masutani
- Organizer
  FASEB Science Research Conference
- Place of Presentation
  Montana, USA
- Year and Date
  2016-06-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K00547
[Presentation] 低線量長期放射線照射細胞におけるミトコンドリア由来活性酸素の蓄積と酸化2016
- Author(s)
  志村勉、笹谷めぐみ、河合秀彦、神谷研二、欅田尚樹
- Organizer
  第59回日本放射線影響学会
- Place of Presentation
  広島市
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-16K00547
[Presentation] 次世代シーケンサーを用いた放射線誘発変異解析2016
- Author(s)
  金井昭教1、長町安希子、河合秀彦、松井啓隆、神谷研二、稲葉俊哉
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜市
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K00547
[Presentation] The function of Chromatin Remodeling Complexes in Cell-fate Decision in Response to Chronic Ionizing Irradiation2015
- Author(s)
  Cao L, Kawai H, Inaba T, Suzuki F, Kamiya K.
- Organizer
  15th International Congress of Radiation Research
- Place of Presentation
  Kyoto, JAPAN
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] Effects of low dose gamma irradiation on primary human endothelial cells2015
- Author(s)
  Elena Zaharieva、河合秀彦、稲葉俊哉、松浦伸也、神谷研二
- Organizer
  広島大学原爆放射線医科学研究所第５回国際シンポジウム
- Place of Presentation
  広島市
- Year and Date
  2015-03-03
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] The effect low dose radiation exposure in the first hours after fertilization on the development of early mouse embryos2015
- Author(s)
  清水なつみ、河合秀彦、笹谷めぐみ、遠藤充浩、稲葉俊哉、神谷研二
- Organizer
  広島大学原爆放射線医科学研究所第５回国際シンポジウム
- Place of Presentation
  広島市
- Year and Date
  2015-03-03
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] 放射線照射環境での細胞応答の解析2015
- Author(s)
  河合秀彦
- Organizer
  変異機構研究会第２８回夏の学校
- Place of Presentation
  小牧市
- Year and Date
  2015-07-25
- Invited
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] Enhanced DNA End Resection and Subsequent Responses During The Processing of Complex DNA Double Strand Breaks Induced By Heavy Ion Beams2015
- Author(s)
  Yajima H, Liu C, Xue L, Fujisawa H, Nakajima N, Kawai H.
- Organizer
  15th International Congress of Radiation Research
- Place of Presentation
  Kyoto, JAPAN
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] Analysis of Radiation Induced Mutations Using Next Generation Sequencer2015
- Author(s)
  Kanai A, Nagamachi A, Kawai H, Matsui H, Kamiya K, Inaba T.
- Organizer
  15th International Congress of Radiation Research
- Place of Presentation
  Kyoto, JAPAN
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] Dose rate-dependent cellular senescence in response to chronic γ-irradiation via the ATM/TP53/p21 pathway2015
- Author(s)
  曹麗麗、河合秀彦、笹谷めぐみ、飯塚大輔、稲葉俊哉、神谷研二、鈴木文男
- Organizer
  広島大学原爆放射線医科学研究所第５回国際シンポジウム
- Place of Presentation
  広島市
- Year and Date
  2015-03-03
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] DNA Damage Response in Human Induced Pluripotent Stem Cells2015
- Author(s)
  嶋本顕、香川晴信、河合秀彦、佐久間哲史、山本卓、塩谷文章、田原栄俊
- Organizer
  広島大学原爆放射線医科学研究所第５回国際シンポジウム
- Place of Presentation
  広島市
- Year and Date
  2015-03-03
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] Comprehensive analyses of cellular responses to chronic γ-irradiation (II)2015
- Author(s)
  河合秀彦、曹麗麗、清水なつみ、笹谷めぐみ、飯塚大輔、松井啓隆、金井昭教、稲葉俊哉、神谷研二、鈴木文男
- Organizer
  広島大学原爆放射線医科学研究所第５回国際シンポジウム
- Place of Presentation
  広島市
- Year and Date
  2015-03-03
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] Perturbation of AKT/cyclin D1 signaling pathway by oxidative stresses following low dose long-term fractionated radiation in human human fibroblasts2015
- Author(s)
  志村勉、笹谷めぐみ、神谷研二、河合秀彦、欅田尚樹
- Organizer
  広島大学原爆放射線医科学研究所第５回国際シンポジウム
- Place of Presentation
  広島市
- Year and Date
  2015-03-03
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] An Integrated Approach Using High-throughput Sequencing and Imaging Technologies to the Study of Cellular Responses to Low Dose Radiation2015
- Author(s)
  Kawai H, Cao L, Shimizu N, Matsui H, Kanai A, Hirouchi T, Inaba T, Kamiya K, Suzuki F.
- Organizer
  15th International Congress of Radiation Research
- Place of Presentation
  Kyoto, JAPAN
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] Differential Response to Acute and Chronic Low Dose Gamma Irradiation in Primary Human Endothelial Cells2015
- Author(s)
  Zaharieva E, Kawai H, Inaba T, Matsuura S, Kamiya K.
- Organizer
  15th International Congress of Radiation Research
- Place of Presentation
  Kyoto, JAPAN
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] 低線量（率）放射線がマウス着床前期胚発生過程に与える影響2015
- Author(s)
  清水なつみ，河合秀彦，笹谷めぐみ，遠藤充浩，稲葉俊哉，神谷研二
- Organizer
  第５６回原子爆弾後障害研究会
- Place of Presentation
  広島市
- Year and Date
  2015-06-07
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] 次世代シーケンサーを用いた放射線誘発変異解析2015
- Author(s)
  金井昭教，長町安希子，河合秀彦，松井啓隆，神谷研二，稲葉俊哉
- Organizer
  第４０回中国地区放射線影響研究会
- Place of Presentation
  東広島市
- Year and Date
  2015-07-17
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] Novel Mechanism of Human PCNA Ubiquitination Mediated by Two E2- E3 Pairs2015
- Author(s)
  Masuda Y, Suzuki M, Kawai H, Hishiki A, Hashimoto H, Masutani C, Hishida T, Suzuki F, Kamiya K.
- Organizer
  15th International Congress of Radiation Research
- Place of Presentation
  Kyoto, JAPAN
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] ハイスループット解析技術による放射線照射環境下での細胞応答の研究2015
- Author(s)
  河合秀彦，曹麗麗，金井昭教，稲葉俊哉，神谷研二，鈴木文男
- Organizer
  第１回放射線ワークショップ
- Place of Presentation
  富山市
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] DNA Damage Response in Human Induced Pluripotent Stem Cells2015
- Author(s)
  Shimamoto A, Kagawa H, Kawai H, Sakuma T, Yamamoto T, Shiotani B, Tahara H.
- Organizer
  15th International Congress of Radiation Research
- Place of Presentation
  Kyoto, JAPAN
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] The Effect of Low Dose Radiation on The Development of Early Mouse Embryos2015
- Author(s)
  Shimizu N, Kawai H, Sasatani M, Endoh M, Inaba T, Kamiya K.
- Organizer
  15th International Congress of Radiation Research
- Place of Presentation
  Kyoto, JAPAN
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] RAD18 Activates The G2/M Checkpoint Through DNA Damage Signaling to Maintain Genome Integrity By Ionizing Radiation2015
- Author(s)
  Sasatani M, Xu Y, Kawai H, Cao L, Tateishi S, Li J, Iizuka D, Kamiya K.
- Organizer
  15th International Congress of Radiation Research
- Place of Presentation
  Kyoto, JAPAN
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] 放射線によるDNA損傷シグナル活性化におけるRAD18の寄与2015
- Author(s)
  笹谷めぐみ，徐衍賓，河合秀彦，飯塚大輔，神谷研二
- Organizer
  第５６回原子爆弾後障害研究会
- Place of Presentation
  広島市
- Year and Date
  2015-06-07
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] γ線照射環境での細胞運命決定とその制御因子の同定2015
- Author(s)
  曹麗麗，河合秀彦，稲葉俊哉，鈴木文男，神谷研二
- Organizer
  第５６回原子爆弾後障害研究会
- Place of Presentation
  広島市
- Year and Date
  2015-06-07
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] Analysis of radiation induced mutations using next generation sequencer2015
- Author(s)
  金井昭教、長町安希子、河合秀彦、松井啓隆、神谷研二、稲葉俊哉
- Organizer
  広島大学原爆放射線医科学研究所第５回国際シンポジウム
- Place of Presentation
  広島市
- Year and Date
  2015-03-03
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] 糖鎖修飾を指標とした放射線被ばくのバイオマーカー探索2014
- Author(s)
  飯塚大輔、桐山慧大、岡崎恵美、河合秀彦、泉俊輔、神谷研二
- Organizer
  第55回原子爆弾後障害研究会
- Place of Presentation
  長崎市
- Year and Date
  2014-06-01
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] RAD18 mediates DNA damage signaling to activate G2/M checkpoint for maintaining genome integrity after ionizing radiation exposure2014
- Author(s)
  徐衍賓、笹谷めぐみ、河合秀彦、曹麗麗、飯塚大輔、神谷研二
- Organizer
  日本放射線影響学会第57回大会
- Place of Presentation
  鹿児島市
- Year and Date
  2014-10-02
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] 人工多能性幹細胞（iPS 細胞）のX 線高感受性の分子機構2014
- Author(s)
  嶋本顕、香川晴信、河合秀彦、佐久間哲史、山本卓、塩谷文章、田原栄俊
- Organizer
  日本放射線影響学会第57回大会
- Place of Presentation
  鹿児島市
- Year and Date
  2014-10-01
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] 異なる線量率での放射線被曝環境と細胞運命決定機構2014
- Author(s)
  河合秀彦、曹麗麗、笹谷めぐみ、飯塚大輔、松井啓隆、金井昭教、稲葉俊哉、神谷研二、鈴木文男
- Organizer
  日本放射線影響学会第57回大会
- Place of Presentation
  鹿児島市
- Year and Date
  2014-10-02
- Invited
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] A combination of experimental and bioinformatics approaches for assessing the biological effects of ionizing radiation2014
- Author(s)
  河合秀彦、曹麗麗、飯塚大輔、松井啓隆、金井昭教、稲葉俊哉、笹谷めぐみ、神谷研二、鈴木文男
- Organizer
  広島大学原爆放射線医科学研究所・第４回国際シンポジウム
- Place of Presentation
  広島市
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] iPS cells show hypersensitivity to X-irradiation than isogenic somatic cells, leading to p53-depedent apoptosis2014
- Author(s)
  香川晴信、河合秀彦、佐久間哲史、山本卓、嶋本顕、田原栄俊
- Organizer
  広島大学原爆放射線医科学研究所・第４回国際シンポジウム
- Place of Presentation
  広島市
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] 次世代シーケンサーを用いた放射線誘発変異解析2014
- Author(s)
  金井昭教、長町安希子、河合秀彦、松井啓隆、稲葉俊哉
- Organizer
  第55回原子爆弾後障害研究会
- Place of Presentation
  長崎市
- Year and Date
  2014-06-01
- Data Source
  KAKENHI-PROJECT-25550030
[Presentation] 次世代シーケンサーを用いた放射線誘発変異解析2014
- Author(s)
  金井昭教、長町安希子、河合秀彦、松井啓隆、稲葉俊哉
- Organizer
  第55回原子爆弾後障害研究会
- Place of Presentation
  長崎市
- Year and Date
  2014-06-01
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] γ線照射環境での線量率依存的な老化様細胞増殖停止はATM/TP53/P21経路依存的である2014
- Author(s)
  曹麗麗、河合秀彦、笹谷めぐみ、飯塚大輔、松井啓隆、金井昭教、稲葉俊哉、神谷研二、鈴木文男
- Organizer
  日本放射線影響学会第57回大会
- Place of Presentation
  鹿児島市
- Year and Date
  2014-10-02
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] 次世代シーケンサーを用いた放射線誘発変異解析にむけた方法論の確立2014
- Author(s)
  金井昭教、松井啓隆、長町安希子、河合秀彦、稲葉俊哉
- Organizer
  第39回中国地区放射線影響研究会
- Place of Presentation
  広島市
- Year and Date
  2014-07-18
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] Ｅ３ユビキチンライゲースRAD18が放射線損傷応答におよぼす寄与2014
- Author(s)
  徐衍賓、笹谷めぐみ、河合秀彦、飯塚大輔、神谷研二
- Organizer
  第55回原子爆弾後障害研究会
- Place of Presentation
  長崎市
- Year and Date
  2014-06-01
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] 放射線照射環境における線量率に依存した細胞運命決定機構の解析2014
- Author(s)
  河合秀彦、曹麗麗、清水なつみ、笹谷めぐみ、飯塚大輔、金井昭教、松井啓隆、稲葉俊哉、神谷研二、鈴木文男
- Organizer
  第39回中国地区放射線影響研究会
- Place of Presentation
  広島市
- Year and Date
  2014-07-18
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] 次世代シーケンサーを用いた放射線誘発変異解析2014
- Author(s)
  金井昭教、長町安希子、河合秀彦、松井啓隆、稲葉俊哉
- Organizer
  第39回中国地区放射線影響研究会
- Place of Presentation
  広島市
- Year and Date
  2014-07-18
- Data Source
  KAKENHI-PROJECT-25550030
[Presentation] 次世代シーケンサーを用いた放射線誘発変異解析2014
- Author(s)
  金井昭教、長町安希子、河合秀彦、松井啓隆、稲葉俊哉
- Organizer
  日本放射線影響学会第57回大会
- Place of Presentation
  鹿児島市
- Year and Date
  2014-10-02
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] 大量データ解析を駆使した放射線影響解析手法の確立にむけて2014
- Author(s)
  松井啓隆、河合秀彦、金井昭教、稲葉俊哉
- Organizer
  日本放射線影響学会第57回大会
- Place of Presentation
  鹿児島市
- Year and Date
  2014-10-01
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] γ線照射環境下での線量率依存的な細胞運命決定とその分子機構の解析2014
- Author(s)
  曹麗麗、河合秀彦、笹谷めぐみ、飯塚大輔、松井啓隆、金井昭教、稲葉俊哉、神谷研二、鈴木文男
- Organizer
  第55回原子爆弾後障害研究会
- Place of Presentation
  長崎市
- Year and Date
  2014-06-01
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] 次世代シーケンサーを用いた放射線誘発変異解析2013
- Author(s)
  金井昭教、長町安希子、河合秀彦、松井啓隆、稲葉俊哉
- Organizer
  日本放射線影響学会第56回大会
- Place of Presentation
  青森市
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] γ線照射環境下における細胞応答の線量率依存性の解析2013
- Author(s)
  河合秀彦、曹麗麗、飯塚大輔、松井啓隆、金井昭教、稲葉俊哉、笹谷めぐみ、神谷研二、鈴木文男
- Organizer
  日本放射線影響学会第56回大会
- Place of Presentation
  青森市
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] DOSE-RATE-DEPENDENT CELLULAR RESPONSES TO CHRONIC γ-IRRADIATION2013
- Author(s)
  曹麗麗、河合秀彦、飯塚大輔、松井啓隆、金井昭教、稲葉俊哉、笹谷めぐみ、神谷研二、鈴木文男
- Organizer
  THE 3rd ASIAN CONGRESS OF RADIATION RESEARCH
- Place of Presentation
  北京　中国
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] 人工多能性幹細胞における X 線に対する高感受性細胞死の p53 依存的な誘導機構の解明2013
- Author(s)
  香川晴信、河合秀彦、佐久間哲史、山本卓、塩谷文章、嶋本顕、田原栄俊
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] Comprehensive analysis of cellular responses to chronic γ-irradiation2013
- Author(s)
  河合秀彦
- Organizer
  3rd International Symposium of RIRBM
- Place of Presentation
  広島市
- Year and Date
  2013-02-13
- Data Source
  KAKENHI-PROJECT-23710069
[Presentation] 慢性的な放射線照射に対する細胞応答機構の解析2012
- Author(s)
  河合秀彦
- Organizer
  第37回中国地区放射線影響研究会
- Place of Presentation
  広島市
- Year and Date
  2012-07-27
- Data Source
  KAKENHI-PROJECT-23710069
[Presentation] 異なる線量率のγ線照射下での細胞応答の多次元解析2012
- Author(s)
  河合秀彦
- Organizer
  日本放射線影響学会第55回大会
- Place of Presentation
  仙台市
- Year and Date
  2012-09-08
- Data Source
  KAKENHI-PROJECT-23710069
[Presentation] The role of p53 in human iPS cells in the cellular response to DNA-damage2012
- Author(s)
  河合秀彦
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡市
- Year and Date
  2012-12-13
- Data Source
  KAKENHI-PROJECT-23710069
[Presentation] 恒常的な放射線照射に対する細胞応答の線量率依存性の解析2011
- Author(s)
  河合秀彦
- Organizer
  第52回原子爆弾後障害研究会
- Place of Presentation
  広島市
- Year and Date
  2011-06-05
- Data Source
  KAKENHI-PROJECT-23710069
[Presentation] γ線の照射環境下での細胞応答の線量率依存性の解析2011
- Author(s)
  河合秀彦
- Organizer
  日本放射線影響学会第54回大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23710069
[Presentation] 恒常的な放射線照射に対する細胞応答の線量率依存性の解析2011
- Author(s)
  河合秀彦
- Organizer
  第52回原子爆弾後障害研究会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23710069
[Presentation] γ線の照射環境下での細胞応答の線量率依存性の解析2011
- Author(s)
  河合秀彦
- Organizer
  日本放射線影響学会第54回大会
- Place of Presentation
  神戸市
- Year and Date
  2011-11-19
- Data Source
  KAKENHI-PROJECT-23710069
[Presentation] MDM2ファミリーによるP53の安定性と放射線応答の制御機構2009
- Author(s)
  河合秀彦
- Organizer
  日本放射線影響学会第52回大会
- Place of Presentation
  広島市
- Year and Date
  2009-11-11
- Data Source
  KAKENHI-PROJECT-20710044
[Presentation] Analysis of the molecular mechanism of p53 ubiquitination by the MDM2-MDMX E3 ubiquitin ligase complex2009
- Author(s)
  河合秀彦
- Organizer
  2nd Asian Congress of Radiation Research
- Place of Presentation
  ソウル(大韓民国)
- Year and Date
  2009-05-17
- Data Source
  KAKENHI-PROJECT-20710044
[Presentation] p53制御機構におけるMDM2/MDMXヘテロ複合体の機能解析2008
- Author(s)
  河合秀彦
- Organizer
  日本放射線影響学会第51回大会
- Place of Presentation
  北九州市
- Year and Date
  2008-11-19
- Data Source
  KAKENHI-PROJECT-20710044
[Presentation] The essential role of MDM2/MDMX complex in the regulation of p53.2008
- Author(s)
  Kawai, H.
- Organizer
  The Fifth International Symposium of the Hiroshima University 21st Century COE Program
- Place of Presentation
  広島市
- Year and Date
  2008-01-23
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17310035
[Presentation] The essential role of MDM2/MDMX complex in the regulatton of p532008
- Author(s)
  Kawai, H
- Organizer
  The Fifth International Symposium on Hiroshima University 21st Casualty Medical Research Center
- Place of Presentation
  Hiroshima
- Year and Date
  2008-01-23
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17310035
[Presentation] The functional analysis of the MDM2-MDMX complex as an E3 ubiquitin ligase for p532008
- Author(s)
  河合秀彦
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋市
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-20710044
[Presentation] MDM2-MDMX複合体とE3ユビキチンリガーゼ活性2008
- Author(s)
  河合秀彦
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸市
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-20710044
[Presentation] The analysis of the function for MDM2-family as a negative rerulator for p532007
- Author(s)
  Kawai, H
- Organizer
  The 66th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Yokohama
- Year and Date
  2007-10-03
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17310035
[Presentation] The regulation of p53 stability by MDM2/114DMX heterocomplex2007
- Author(s)
  Kawai, H
- Organizer
  The 50th Annual Meeting of the Japan Radiation Research Society
- Place of Presentation
  Chiba
- Year and Date
  2007-11-15
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17310035
[Presentation] The analysis of the function for MDM2-family as a negative regulator for p53.2007
- Author(s)
  Kawai, Hidehiko
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜市
- Year and Date
  2007-10-03
- Data Source
  KAKENHI-PROJECT-17310035
[Presentation] MDM2ファミリーのリンングフィンガードメインを介した複合体形成とE3ユビキチンリガーゼ.2007
- Author(s)
  河合, 秀彦
- Organizer
  第30回日本分子生物学会年会
- Place of Presentation
  横浜市
- Year and Date
  2007-12-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17310035
[Presentation] MDM2/MDMXヘテロ複合体によるp53安定性制御2007
- Author(s)
  河合, 秀彦
- Organizer
  日本放射線影響学会第50回大会
- Place of Presentation
  千葉市
- Year and Date
  2007-11-15
- Data Source
  KAKENHI-PROJECT-17310035
[Presentation] p53制御因子としてのMDM2ファミリーの機能解析.2007
- Author(s)
  河合, 秀彦
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜市
- Year and Date
  2007-10-03
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17310035
[Presentation] Ring finger domain-mediated interaction is a requirement for MDM2'E3 ubiquitin ligase activity2007
- Author(s)
  Kawai, H
- Organizer
  The 30th Annual Meeting of the Molecular Biology Society of Japan & the 80th Annual Meeting of the Biochemistry Society of Japan
- Place of Presentation
  Yokohama
- Year and Date
  2007-12-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17310035
[Presentation] MDM2/MDMXヘテロ複合体によるp53安定性制御.2007
- Author(s)
  河合, 秀彦
- Organizer
  日本放射線影響学会大会第50回大会
- Place of Presentation
  千葉市
- Year and Date
  2007-11-15
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17310035
[Presentation] Aurora-B regulates RNA methylation2006
- Author(s)
  Kawai, H
- Organizer
  The 65th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Yokohama
- Year and Date
  2006-09-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17310035
[Presentation] オーロラBによるRNAメチル化の制御.2006
- Author(s)
  河合, 秀彦
- Organizer
  第65回日本癌学会学術総会
- Place of Presentation
  横浜市
- Year and Date
  2006-09-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17310035
[Presentation] Suppressor gene p53 by MDM2 family2006
- Author(s)
  Kawai, H
- Organizer
  The 76th Annual Meeting of the Japanese Society for Hygiene
- Place of Presentation
  Ube
- Year and Date
  2006-03-27
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17310035
[Presentation] MDM2ファミリーによるがん抑制遺伝子p53の制御.2006
- Author(s)
  河合, 秀彦
- Organizer
  第76回日本衛生学会総会ミニシンポジウム
- Place of Presentation
  宇部市
- Year and Date
  2006-03-27
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17310035
[Presentation] 電離放射線誘発細胞死シグナルにおける分断化LyGDIの機能解析.2006
- Author(s)
  河合, 秀彦
- Organizer
  第47回原子爆弾後障害研究会
- Place of Presentation
  長崎市
- Year and Date
  2006-06-04
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17310035
[Presentation] Caspase-3 mediated cleavage of LyGDI in ionizing irradiated cells : Expression of the cleaved LyGDI induces cell death2006
- Author(s)
  Kawai, H
- Organizer
  The 47th Conference of Atomic Bomb Disease
- Place of Presentation
  Nagasaki
- Year and Date
  2006-06-04
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17310035
[Presentation] 放射線照射環境下での細胞応答とその分子機構
- Author(s)
  河合秀彦、曹麗麗、飯塚大輔、松井啓隆、金井昭教、稲葉俊哉、笹谷めぐみ、神谷研二、鈴木文男
- Organizer
  第38回中国地区放射線影響研究会
- Place of Presentation
  広島市
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] 恒常的な放射線被曝環境下のゲノム安定性維持にはATM-p53-p21経路の活性化が必要である
- Author(s)
  曹麗麗、河合秀彦、笹谷めぐみ、飯塚大輔、松井啓隆、金井昭教、稲葉俊哉、神谷研二、鈴木文男
- Organizer
  第54回原子爆弾後障害研究会
- Place of Presentation
  広島市
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] 次世代シーケンサーを用いた放射線誘発変異解析
- Author(s)
  金井昭教、長町安希子、河合秀彦、松井啓隆、稲葉俊哉
- Organizer
  日本放射線影響学会第57回大会
- Place of Presentation
  鹿児島市
- Year and Date
  2014-10-01 – 2014-10-03
- Data Source
  KAKENHI-PROJECT-25550030
[Presentation] 低線量率放射線被曝生体影響の細胞生物学的研究
- Author(s)
  河合秀彦
- Organizer
  第54回原子爆弾後障害研究会
- Place of Presentation
  広島市
- Invited
- Data Source
  KAKENHI-PROJECT-25340033
[Presentation] 人工多能性幹細胞における X 線に対する高感受性細胞死のp53依存的な誘導機構の解明
- Author(s)
  香川晴信，河合秀彦，佐久間哲史，山本卓，塩谷文章，嶋本顕，田原栄俊
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-25670030
[Presentation] 次世代シーケンサーを用いた放射線誘発変異解析
- Author(s)
  金井昭教、長町安希子、河合秀彦、松井啓隆、稲葉俊哉
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜市
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25550030
[Presentation] The role of p53 in human iPS cells in the cellular response to DNA-damage
- Author(s)
  河合秀彦
- Organizer
  第３５回日本分子生物学会年回
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-23710069
[Presentation] 慢性的な放射線照射に対する細胞応答機構の解析
- Author(s)
  河合秀彦
- Organizer
  第３７回中国地区放射線影響研究会
- Place of Presentation
  広島市
- Data Source
  KAKENHI-PROJECT-23710069

1. KAMIYA Hiroyuki (10204629)

# of Collaborated Projects: 4 results

# of Collaborated Products: 23 results
2. Sasatani Megumi (80423052)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. Kamiya Kenji (60116564)

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4. 鈴木哲矢 (20573950)

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5. SUZUKI Fumio (10019672)

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6. SHIMAMOTO AKIRA (70432713)

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7. 林田耕臣 (10882061)

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8. 神代紗央理 (60882058)

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9. ZAHARIEVA ELENA (30766697)

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10. KANAI Akinori (60549567)

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11. YAMAMOTO Takashi (90244102)

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12. FURUE Miho (80257310)

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13. KUDO Yasusei (50314753)

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14. Sakai Norio (70263407)

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15. 岡本哲治 (00169153)

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16. 宮本洋二 (20200214)

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17. 石丸直澄 (60314879)

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18. 常松貴明 (70726752)

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19. 長町安希子 (20585153)

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20. 本庶仁子 (80614106)

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24. 杉田誠 (50235884)

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26. 小松康雄 (30271670)

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27. TOYOSHIMA Megumi

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# of Collaborated Products: 34 results
28. SAJI Tetsuya

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29. KANAO Rie

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30. 増田雄司

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31. 若杉光生

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32. 松永司

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33. 柊元巌

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34. 志村勉

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35. 谷時雄

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36. 小松賢志

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37. 小林純也

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Kawai Hidehiko 河合 秀彦

KAWAI Hidehiko 河合 秀彦

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放射線誘発性細胞老化と細胞傷害による多層的変異シグネチャー生成メカニズムの解析Principal Investigator

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老化細胞誘発クラスター性変異のNGS解析による放射線発がん機構研究Principal Investigator

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Analysis of the function of the senescent cells for exploring the link between ionizing radiation and carcinogenesisPrincipal Investigator

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Advanced radiation research using comprehensive multi-high-throughput technologiesPrincipal Investigator

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Advanced research on the biological effects of genotoxic stress using different irradiation conditions and induced pluripotent cellsPrincipal Investigator

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Kawai Hidehiko 河合秀彦

KAWAI Hidehiko 河合秀彦