Yamashita Tomohiro 山下智大

… Alternative Names

YAMASHITA Tomohiro 山下智大

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Researcher Number	30645635
Other IDs
Affiliation (Current)	2025: 九州大学, 薬学研究院, 講師
Affiliation (based on the past Project Information) *help	2022 – 2024: 九州大学, 薬学研究院, 講師 2017 – 2021: 九州大学, 薬学研究院, 助教 2014: 九州大学, 薬学研究科(研究院), 特任助教 2013: 九州大学, 薬学研究科(研究院), 研究員
Review Section/Research Field	Principal Investigator Basic Section 48030:Pharmacology-related / Neurochemistry/Neuropharmacology Except Principal Investigator Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Basic Section 55020:Digestive surgery-related / Basic Section 55010:General surgery and pediatric surgery-related / Broad Section I / Chemical biology
Keywords	Principal Investigator 化合物スクリーニング / DRGニューロン / ドラッグリポジショニング / マスト細胞 / オーファンGPCR / エコファーマ / かゆみ / Mas関連Gタンパク質共役型受容体 / 慢性掻痒 / 創薬 … More / 肥満細胞 / DRG神経 / MRGPR / 末梢神経系 / MRGPRs / 痒み伝達機構 / 化合物ライブラリー / 創薬スクリーニング / Mrgpr / 既承認薬 / 末梢神経刺激 / 脊髄後角 / MrgprC11 / MrgprA3 / 痒み / MRGPRC11 / MRGPRA3 / 創薬探索 / DRG / アカデミア創薬 / IL-1β / P2X7受容体 / 慢性炎症 / ATP受容体 / サイトカイン / 医薬品探索 / ミクログリア … More Except Principal Investigator 樹状細胞 / P2X4受容体 / タンパク質化学 / オートファジー / 抗腫瘍免疫 / 免疫抑制性微小環境 / Autophagy / 膵癌 / 抗原提示能 / 抗原性 / 腫瘍免疫 / CD4 / CD8 / 細胞傷害性Tリンパ球 / 活性化リンパ球 / 癌免疫治療 / 非抗体型免疫チェックポイント阻害剤 / 癌組織浸潤リンパ球 / 新規がん免疫治療 / 薬剤スクリーニング / 低分子化合物 / CD4リンパ球 / CD8リンパ球 / 免疫チェックポイント阻害剤 / PTPN3 / Fab / 大腸菌発現系 / 抗体工学 / 大腸菌発現 / タンパク質工学 / 抗P2X4抗体 / 脊髄後角神経回路 / 光遺伝学 / 一次求心性神経Aβ線維 / 神経障害性アロディニア / 痛み創薬 / 蛋白質科学 / モノクローナル抗体 / 神経障害性疼痛 / 抗体 / P2X4 / マイトファジー / ミトコンドリア Less

かゆみの伝達および慢性化にかかわるMRGPRsの多様性解明と新たな治療薬の創出Principal Investigator
- Principal Investigator
  
  山下智大
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Kyushu University
オートファジー依存性がん抗原放出機構の解明および免疫提示システムの強化改変
- Principal Investigator
  
  仲田興平
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyushu University
Development of cancer immunotherapy using non-receptor type immune checkpoint inhibitor targeting PTPN3
- Principal Investigator
  
  中山和典
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Kyushu University
Improvement of protein expression by Escherichia coli based on the structure of anti-P2X4 antibody Fab and development of its additional function.
- Principal Investigator
  
  Abe Yoshito
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  International University of Health and Welfare
かゆみ伝達に対するMRGPRの包括的研究および創薬シーズの探索Principal Investigator
- Principal Investigator
  
  山下智大
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Kyushu University
Unravelling the role of MRGPRs in itch transmission using activity compounds acquired by drug screening and the potential for drug discoveryPrincipal Investigator
- Principal Investigator
  
  Yamashita Tomohiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Kyushu University
Elucidation of abnormal functioning of neuronal circuits underlying neuropathic pain and its application for drug discovery
- Principal Investigator
  
  Tsuda Makoto
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section I
- Research Institution
  Kyushu University
Development of Pain-Inhibiting Derivatized Antibodies Using High-Affinity Antibodies to P2X4
- Principal Investigator
  
  Abe Yoshito
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  International University of Health and Welfare
  Kyushu University
Drug discovery and research for regulation of chronic inflammation caused by microglial activationPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Tomohiro
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kyushu University
Screen the chemicals that efficiently induce mitophagy
- Principal Investigator
  
  KANKI Tomotake
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Chemical biology
- Research Institution
  Niigata University

All 2023 2022 2021 2020 2019 2018 2015

All Journal Article Presentation Book

[Book] エコファーマによる新規神経障害性疼痛治療薬の探索2019
- Author(s)
  山下智大
- Total Pages
  5
- Publisher
  ファルマシア
- Data Source
  KAKENHI-PROJECT-17K17947
[Journal Article] GPR55 contributes to neutrophil recruitment and mechanical pain induction after spinal cord compression in mice2023
- Author(s)
  Ono Teruaki、Yamashita Tomohiro、Kano Ryota、Inoue Mariko、Okada Shota、Kano Koki、Koizumi Schuichi、Iwabuchi Kazuhisa、Hirabayashi Yoshio、Matsuo Ichiro、Nakashima Yasuharu、Kamiguchi Hiroyuki、Kohro Yuta、Tsuda Makoto
- Journal Title
  
  Brain, Behavior, and Immunity
  
  Volume: 110 Pages: 276-287
- DOI
  10.1016/j.bbi.2023.03.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K23463, KAKENHI-PROJECT-22K19098, KAKENHI-PROJECT-18K14821, KAKENHI-PLANNED-20H05900, KAKENHI-PROJECT-19H05658
[Journal Article] New Inhibitory Effects of Cilnidipine on Microglial P2X7 Receptors and IL-1β Release: An Involvement in its Alleviating Effect on Neuropathic Pain2021
- Author(s)
  Yamashita Tomohiro、Kamikaseda Sawako、Tanaka Aya、Tozaki-Saitoh Hidetoshi、Caaveiro Jose M. M.、Inoue Kazuhide、Tsuda Makoto
- Journal Title
  
  Cells
  
  Volume: 10 Issue: 2 Pages: 434-434
- DOI
  10.3390/cells10020434
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16502, KAKENHI-PLANNED-20H05900, KAKENHI-PROJECT-19H05658
[Journal Article] Involvement of exchange protein directly activated by cAMP and tumor progression locus 2 in IL-1β production in microglial cells following activation of β-adrenergic receptors.2020
- Author(s)
  Tozaki-Saitoh H, Sasaki I, Yamashita T, Hosoi M, Kato TA, Tsuda M
- Journal Title
  
  J Pharmacol Sci.
  
  Volume: pii: S1347-8613(20) Issue: 3 Pages: 30031-1
- DOI
  10.1016/j.jphs.2020.03.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03752, KAKENHI-PROJECT-19H05658, KAKENHI-PROJECT-18H04042
[Journal Article] Evidence for detection of rat P2X4 receptor expressed on cells by generating monoclonal antibodies recognizing the native structure2019
- Author(s)
  Igawa Tatsuhiro、Kishikawa Shuhei、Abe Yoshito、Yamashita Tomohiro、Nagai Saki、Shiroishi Mitsunori、Shinozaki Chinatsu、Tanaka Hiroyuki、Tozaki-Saitoh Hidetoshi、Tsuda Makoto、Inoue Kazuhide、Ueda Tadashi
- Journal Title
  
  Purinergic Signalling
  
  Volume: 15 Issue: 1 Pages: 27-35
- DOI
  10.1007/s11302-019-09646-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06597
[Journal Article] Green Pharma: A New Strategy for Drug Discovery in Academia by Targeting Glial Cells and ATP Receptors2018
- Author(s)
  Yamashita Tomohiro、Tsuda Makoto、Tozaki-Saitoh Hidetoshi、Inoue Kazuhide
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 138 Issue: 8 Pages: 1027-1031
- DOI
  10.1248/yakushi.17-00211-1
- NAID
  130007429840
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2018-08-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K17947
[Journal Article] New pharmacological effect of fulvestrant to prevent oxaliplatin-induced neurodegeneration and mechanical allodynia in rats2018
- Author(s)
  Yamamoto S, Yamashita T, Ito M, Caaveiro JMM, Egashira N, Tozaki-Saitoh H, Tsuda M
- Journal Title
  
  Int J Cancer
  
  Volume: - Issue: 8 Pages: 2107-2113
- DOI
  10.1002/ijc.32043
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08953, KAKENHI-PROJECT-15H02522, KAKENHI-PROJECT-17K17947
[Journal Article] Mitophagy is primarily due to alternative autophagy and requires MAPK1 and MAPK14 signaling pathway.2015
- Author(s)
  Hirota, Y.,Yamashita, S., Kurihara, Y., Jin, X., Aihara, M., Saigusa, T., Kang, D., and Kanki, T.
- Journal Title
  
  Autophagy
  
  Volume: 11 Issue: 2 Pages: 332-43
- DOI
  10.1080/15548627.2015.1023047
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13J04836, KAKENHI-PUBLICLY-25117714, KAKENHI-PROJECT-25560414, KAKENHI-PROJECT-26291039, KAKENHI-PROJECT-15K18501, KAKENHI-PROJECT-25253041
[Journal Article] Mitophagy in yeast: Molecular mechanisms and physiological role.2015
- Author(s)
  Kanki T, Furukawa K, Yamashita SI.
- Journal Title
  
  Biochim Biophys Acta.
  
  Volume: 印刷中 Issue: 10 Pages: 2756-2765
- DOI
  10.1016/j.bbamcr.2015.01.005
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-25117714, KAKENHI-PROJECT-25560414, KAKENHI-PROJECT-26291039, KAKENHI-PROJECT-15K18501
[Presentation] 化合物スクリーニングによって発見した新たなMRGPRA3アゴニストは非ヒスタミン性のかゆみを誘発する2023
- Author(s)
  山下智大, 伊藤麻結, 川浪侑華, 古賀啓祐, 兼久賢章, 藤井志織, 津田誠
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K06804
[Presentation] A newly discovered MRGPRA3 agonist by high-throughput screening induces scratching behaviors2022
- Author(s)
  Tomohiro Yamashita, Mayu Ito, Yuka Kawanami, Keisuke Koga, Kensho Kanehisa, Shiori Fujii, Jose M. M. Caaveiro, Makoto Tsuda.
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K16502
[Presentation] A newly discovered MRGPRA3 agonist by high-throughput screening induces scratching behaviors2022
- Author(s)
  Tomohiro Yamashita, Mayu Ito, Yuka Kawanami, Keisuke Koga, Kensho Kanehisa, Shiori Fujii, Jose M. M. Caaveiro, Makoto Tsuda.
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K06804
[Presentation] Therapeutic approach for the treatment of neuropathic pain by the inhibition of microglial P2X7 receptors from among approved drugs2021
- Author(s)
  Tomohiro Yamashita, Sawako Kamikaseda, Aya Tanaka, Hidetoshi Tozaki-Saitoh, Jose M. M. Caaveiro, Kazuhide Inoue, Makoto Tsuda
- Organizer
  PURINES 2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16502
[Presentation] Preparation of monoclonal antibody for rat P2X4 receptor recognizing the native structure2019
- Author(s)
  Yoshito Abe, Tatsuhiro Igawa, Shuhei Kishikawa, Tomohiro Yamashita, Hiroyuki Tanaka, Hidetoshi Tozaki-Saitoh, Makoto Tsuda, Kazuhide Inoue, Tadashi Ueda
- Organizer
  Neuro2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06597
[Presentation] Discovery of a new MrgprA3 agonist and evaluation of its effect for itch sensation (新規MrgprA3アゴニストの発見およびかゆみ感覚に対するその評価)2019
- Author(s)
  Tomohiro Yamashita (山下智大)
- Organizer
  第93回日本薬理学会年会（誌上開催）
- Data Source
  KAKENHI-PROJECT-19K16502
[Presentation] New pharmacological effects of approved drugs targeting P2X7 receptors against the release of IL-1β from microglial cells and neuropathic pain after peripheral nerve injury2018
- Author(s)
  Tomohiro Yamashita, Sawako Kamikaseda, Aya Tanaka, Hidetoshi Tozaki-Saitoh, Makoto Tsuda, and Kazuhide Inoue
- Organizer
  WCP2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17947
[Presentation] Drug discovery technologies to achieve pain relief through drug repositioning approaches2018
- Author(s)
  山下智大
- Organizer
  第92回日本薬理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K17947
[Presentation] New pharmacological effects of approved drugs targeting P2X7 receptors against the release of IL-1β from microglial cells and neuropathic pain after peripheral nerve injury2018
- Author(s)
  Tomohiro Yamashita, Sawako Kamikaseda, Aya Tanaka, Hidetoshi Tozaki-Saitoh, Makoto Tsuda, and Kazuhide Inoue
- Organizer
  PURINES 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17947
[Presentation] アドレナリン受容体を介したミクログリアの炎症応答調節2018
- Author(s)
  笹木泉, 山下智大, 齊藤秀俊, 津田誠
- Organizer
  第35回日本薬学会九州支部会
- Data Source
  KAKENHI-PROJECT-17K17947
[Presentation] Microglial ATP receptors in neuropathic pain2018
- Author(s)
  Kazuhide Inoue and Tomohiro Yamashita
- Organizer
  PURINES 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17947

1. Abe Yoshito (60315091)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. Tsuda Makoto (40373394)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. KANKI Tomotake (50398088)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. YAMASHITA Shun-ichi (30529095)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 八坂敏一 (20568365)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 中山和典 (30915252)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 大西秀哉 (30553276)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 藤村晶子 (60892718)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 大薗慶吾 (60912847)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 仲田興平 (30419569)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 肥川和寛 (50941308)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 池永直樹 (90759755)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 森崎隆 (90291517)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SAITOH Hidetoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
15. Jose Caaveiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. INOUE Kazuhide

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
17. HOSOI Masako

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. EGASHIRA Nobuaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 松尾一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamashita Tomohiro 山下 智大

YAMASHITA Tomohiro 山下 智大

Research Projects

Research Products

Co-Researchers

かゆみの伝達および慢性化にかかわるMRGPRsの多様性解明と新たな治療薬の創出Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

オートファジー依存性がん抗原放出機構の解明および免疫提示システムの強化改変

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of cancer immunotherapy using non-receptor type immune checkpoint inhibitor targeting PTPN3

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Improvement of protein expression by Escherichia coli based on the structure of anti-P2X4 antibody Fab and development of its additional function.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

かゆみ伝達に対するMRGPRの包括的研究および創薬シーズの探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Unravelling the role of MRGPRs in itch transmission using activity compounds acquired by drug screening and the potential for drug discoveryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of abnormal functioning of neuronal circuits underlying neuropathic pain and its application for drug discovery

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of Pain-Inhibiting Derivatized Antibodies Using High-Affinity Antibodies to P2X4

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Drug discovery and research for regulation of chronic inflammation caused by microglial activationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Screen the chemicals that efficiently induce mitophagy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] エコファーマによる新規神経障害性疼痛治療薬の探索2019

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] GPR55 contributes to neutrophil recruitment and mechanical pain induction after spinal cord compression in mice2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] New Inhibitory Effects of Cilnidipine on Microglial P2X7 Receptors and IL-1β Release: An Involvement in its Alleviating Effect on Neuropathic Pain2021

Author(s)

Journal Title

DOI

Data Source

Yamashita Tomohiro 山下智大

YAMASHITA Tomohiro 山下智大