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SHIEN KAZUHIKO  枝園 和彦

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… Alternative Names

SHIEN Kazuhiko  枝園 和彦

枝園 和彦  シエン カズヒコ

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Researcher Number 30708079
Other IDs
Affiliation (Current) 2025: 岡山大学, 医療開発領域, 講師
Affiliation (based on the past Project Information) *help 2020 – 2024: 岡山大学, 大学病院, 講師
2016 – 2020: 岡山大学, 大学病院, 助教
2019: 岡山大学, 大学病院, 客員研究員
2017: 岡山大学, 医歯薬学総合研究科, 助教
2015: 岡山大学, 大学院医歯薬学総合研究科, 助教
2013: 岡山大学, 医歯(薬)学総合研究科, 助教
Review Section/Research Field
Principal Investigator
Basic Section 55040:Respiratory surgery-related / Respiratory surgery / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
Except Principal Investigator
Basic Section 55040:Respiratory surgery-related / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / Respiratory surgery / Basic Section 50010:Tumor biology-related / Basic Section 55010:General surgery and pediatric surgery-related / Tumor biology
Keywords
Principal Investigator
非小細胞肺がん / がん微小環境 / 薬剤耐性 / マルチオミクス解析 / 微小環境 / EGFR / 非小細胞肺癌 / ディスバイオーシス / メタゲノム解析 / COPD … More / 空間解析 / iPS細胞 / オルガノイド / 肺がん / 炎症性サイトカイン / 分子標的薬 / 薬剤反応性 / トランスレーショナルリサーチ / 癌 / マイクロRNA … More
Except Principal Investigator
肺癌 / 薬剤耐性 / がん関連線維芽細胞 / がん微小環境 / 炎症 / EGFR / 線溶阻害因子 / 空間解析 / 腫瘍免疫 / B細胞 / 腫瘍免疫療法 / TLS / 腫瘍浸潤B細胞 / 空間マルチオミクス解析 / 血管内皮細胞 / マトリセルラー蛋白 / マトリセルラータンパク質 / 非小細胞肺がん / 肉腫肺転移 / 腫瘍微小環境 / 肺腺癌 / 腫瘍免疫応答 / 内在性レトロウイルス / HER2 / TDM1 / 耐性化機序 / 乳癌 / 胸部悪性腫瘍 / 抗体療法 / 癌微小環境 / EGFR遺伝子変異 / LRIG1 / 転移 / S100A8/A9受容体 / S100A8/A9 / がん / 外科 / 癌 / 次世代シーケンサー / 分子標的治療薬 / 非小細胞肺癌 / PDX / EMT / 次世代シークエンサー / 分子バーコード / 分子標的薬 / 上皮成長因子受容体チロシンキナーゼ阻害薬 / 上皮間葉移行 / 上皮成長因子受容体チロシンキナーゼ阻害剤 / 癌幹細胞 / 原発性肺癌 Less
  • Research Projects

    (17 results)
  • Research Products

    (43 results)
  • Co-Researchers

    (31 People)
  •  樹状細胞の活性化を介した抗腫瘍免疫応答の増強による新規肺腺癌治療戦略の基礎的検討

    • Principal Investigator
      土生 智大
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55040:Respiratory surgery-related
    • Research Institution
      Okayama University
  •  Clarification of spatiotemporal diversity in tumor microenvironment promoting lung metastases from bone and soft tissue sarcoma

    • Principal Investigator
      山本 寛斉
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55040:Respiratory surgery-related
    • Research Institution
      Shimane University
  •  Development of a novel therapeutic strategy targeting the microenvironment that tolerates the progression of refractory lung cancerPrincipal Investigator

    • Principal Investigator
      枝園 和彦
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55040:Respiratory surgery-related
    • Research Institution
      Okayama University
  •  Functional analysis of TLS, tumor-infiltrating B-cell, by spatial multi-omics profiling and its application to tumor immunotherapy

    • Principal Investigator
      冨田 秀太
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55040:Respiratory surgery-related
    • Research Institution
      Okayama University
  •  メタゲノム解析によるCOPD合併肺がんの臓器横断的ディスバイオーシスの解明Principal Investigator

    • Principal Investigator
      枝園 和彦
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
    • Research Institution
      Okayama University
  •  Elucidation of Tumor Microenvironment Network Regulated by Fibrinolysis Inhibitory Factor and Its Therapeutic Application

    • Principal Investigator
      伊達 慶一
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Okayama University
  •  耐性化機序に基づいたHER2陽性乳癌に対する治療戦略の開発

    • Principal Investigator
      枝園 忠彦
    • Project Period (FY)
      2022 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Okayama University
  •  Clarification of the mechanism for endogenous retrovirus to get involved in the antitumor immunity response

    • Principal Investigator
      豊岡 伸一
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
    • Research Institution
      Okayama University
  •  マトリセルラータンパク質阻害によるがん微小環境の破壊と抗腫瘍効果の検討

    • Principal Investigator
      豊岡 伸一
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55040:Respiratory surgery-related
    • Research Institution
      Okayama University
  •  Novel therapeutic approaches for lung cancer by using iPS cell-derived organoidsPrincipal Investigator

    • Principal Investigator
      Shien Kazuhiko
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 55040:Respiratory surgery-related
    • Research Institution
      Okayama University
  •  Novel therapeutic strategy focused on EGFR-binding protein LRIG1 for EGFR-mutant lung cancer

    • Principal Investigator
      Yamamoto Hiromasa
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55040:Respiratory surgery-related
    • Research Institution
      Okayama University
  •  Development of innovative therapeutic antibodies targeting the inflammatory tumor microenvironment in refractory thoracic tumors

    • Principal Investigator
      Toyooka Shinichi
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
    • Research Institution
      Okayama University
  •  がん微小環境における炎症性サイトカインに着目した肺がん分子標的薬治療抵抗性の克服Principal Investigator

    • Principal Investigator
      枝園 和彦
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Respiratory surgery
    • Research Institution
      Okayama University
  •  Mechanistic analysis of an unidentified downstream signals of S100A8/A9 receptors that play a crucial role in acquisition of metastatic force and formation of cancer microenvironment.

    • Principal Investigator
      Sakaguchi Masakiyo
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Tumor biology
    • Research Institution
      Okayama University
  •  Development of new therapeutic strategy based on gene expression and mutation profiles in EGFR mutant lung cancer

    • Principal Investigator
      Toyooka Shinichi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Respiratory surgery
    • Research Institution
      Okayama University
  •  EGFR-TKI resistance and epigenetic alterations in lung cancer treatmentPrincipal Investigator

    • Principal Investigator
      Shien Kazuhiko
    • Project Period (FY)
      2016
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Respiratory surgery
    • Research Institution
      Okayama University
  •  Understanding and overcoming drug resistance to EGFR-inhibitors for lung cancer

    • Principal Investigator
      Toyooka Shinichi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Respiratory surgery
    • Research Institution
      Okayama University

All 2023 2022 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation Patent

  • [Journal Article] Correction to: Periostin secreted by cancer-associated fibroblasts promotes cancer progression and drug resistance in non-small cell lung cancer2023

    • Author(s)
      Takatsu Fumiaki、Suzawa Ken、Tomida Shuta、Thu Yin Min、Sakaguchi Masakiyo、Toji Tomohiro、Ohki Masayoshi、Tsudaka Shimpei、Date Keiichi、Matsuda Naoki、Iwata Kazuma、Zhu Yidan、Nakata Kentaro、Shien Kazuhiko、Yamamoto Hiromasa、Nakayama Akiko、Okazaki Mikio、Sugimoto Seiichiro、Toyooka Shinichi
    • Journal Title

      Journal of Molecular Medicine

      Volume: 102 Issue: 1 Pages: 147-147

    • DOI

      10.1007/s00109-023-02408-2

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K24421, KAKENHI-PROJECT-23K27439
  • [Journal Article] Periostin secreted by cancer-associated fibroblasts promotes cancer progression and drug resistance in non-small cell lung cancer2023

    • Author(s)
      Takatsu F, Suzawa K, Tomida S, Thu YM, Sakaguchi M, Shien K, Yamamoto H, Nakayama A, Okazaki M, Sugimoto S, Toyooka S
    • Journal Title

      Journal of molecular medicine (Berlin, Germany)

      Volume: 101 Issue: 12 Pages: 1603-1614

    • DOI

      10.1007/s00109-023-02384-7

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22H04923, KAKENHI-PROJECT-23K27439, KAKENHI-PROJECT-23K27688
  • [Journal Article] Identification of genetic loci associated with renal dysfunction after lung transplantation using an ethnic-specific single-nucleotide polymorphism array2023

    • Author(s)
      Tomioka Yasuaki、Sugimoto Seiichiro、Yamamoto Haruchika、Tomida Shuta、Shiotani Toshio、Tanaka Shin、Shien Kazuhiko、Suzawa Ken、Miyoshi Kentaroh、Otani Shinji、Yamamoto Hiromasa、Okazaki Mikio、Yamane Masaomi、Toyooka Shinichi
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 8912-8912

    • DOI

      10.1038/s41598-023-36143-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K08974, KAKENHI-PROJECT-23K27688
  • [Journal Article] Critical role of the MCAM-ETV4 axis triggered by extracellular S100A8/A9 in breast cancer aggressiveness.2019

    • Author(s)
      Chen Y, Sumardika IW, Tomonobu N, Kinoshita R, Inoue Y, Iioka H, Mitsui Y, Saito K, Ruma IMW, Sato H, Yamauchi A, Murata H, Yamamoto KI, Tomida S, Shien K, Yamamoto H, Soh J, Futami J, Kubo M, Putranto EW, Murakami T, Liu M, Hibino T, Nishibori M, Kondo E, Toyooka S, Sakaguchi M.
    • Journal Title

      Neoplasia.

      Volume: 21(7) Issue: 7 Pages: 627-640

    • DOI

      10.1016/j.neo.2019.04.006

    • NAID

      120006948963

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08276, KAKENHI-PROJECT-19K07369, KAKENHI-PROJECT-19K07474, KAKENHI-PROJECT-19K07676, KAKENHI-PROJECT-17H03577, KAKENHI-PROJECT-17H03590, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-18K15320
  • [Journal Article] Melanoma cell adhesion molecule is the driving force behind the dissemination of melanoma upon S100A8/A9 binding in the original skin lesion.2019

    • Author(s)
      Chen Y, Sumardika IW, Tomonobu N, Winarsa Ruma IM, Kinoshita R, Kondo E, Inoue Y, Sato H, Yamauchi A, Murata H, Yamamoto KI, Tomida S, Shien K, Yamamoto H, Soh J, Liu M, Futami J, Sasai K, Katayama H, Kubo M, Putranto EW, Hibino T, Sun B, Nishibori M, Toyooka S, Sakaguchi M
    • Journal Title

      Cancer Lett.

      Volume: - Pages: 178-190

    • DOI

      10.1016/j.canlet.2019.03.023

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H03577, KAKENHI-PROJECT-17H03590, KAKENHI-PROJECT-19K07369, KAKENHI-PROJECT-19K07474, KAKENHI-PROJECT-19K07676, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-18K15320
  • [Journal Article] Anti-tumor effect of neratinib against lung cancer cells harboring HER2 oncogene alterations.2019

    • Author(s)
      Ogoshi Y, Shien K, Yoshioka T, Torigoe H, Sato H, Sakaguchi M, Tomida S, Namba K, Kurihara E, Takahashi Y, Suzawa K, Yamamoto H, Soh J, Toyooka S
    • Journal Title

      Oncol Lett.

      Volume: - Pages: 2729-2736

    • DOI

      10.3892/ol.2019.9908

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H03577, KAKENHI-PROJECT-16K10681
  • [Journal Article] Neuroplastin-β mediates S100A8/A9-induced lung cancer disseminative progression.2019

    • Author(s)
      Sumardika IW, Chen Y, Tomonobu N, Kinoshita R, Ruma IMW, Sato H, Kondo E, Inoue Y, Yamauchi A, Murata H, Yamamoto KI, Tomida S, Shien K, Yamamoto H, Soh J, Futami J, Putranto EW, Hibino T, Nishibori M, Toyooka S, Sakaguchi M
    • Journal Title

      Mol Carcinog.

      Volume: - Issue: 6 Pages: 980-995

    • DOI

      10.1002/mc.22987

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H03577, KAKENHI-PROJECT-19K07369, KAKENHI-PROJECT-19K07474, KAKENHI-PROJECT-17H03590, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-18K15320
  • [Journal Article] Ganetespib in Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor-resistant Non-small Cell Lung Cancer2019

    • Author(s)
      Kurihara Eisuke、Shien Kazuhiko、Torigoe Hidejiro、Takeda Tatsuaki、Takahashi Yuta、Ogoshi Yusuke、Yoshioka Takahiro、Namba Kei、Sato Hiroki、Suzawa Ken、Yamamoto Hiromasa、Soh Junichi、Okazaki Mikio、Shien Tadahiko、Tomida Shuta、Toyooka Shinichi
    • Journal Title

      Anticancer Research

      Volume: 39 Issue: 4 Pages: 1767-1775

    • DOI

      10.21873/anticanres.13283

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K16608
  • [Journal Article] Activation of AXL as a Preclinical Acquired Resistance Mechanism Against Osimertinib Treatment in EGFR-Mutant Non-Small Cell Lung Cancer Cells2019

    • Author(s)
      Namba Kei、Shien Kazuhiko、Takahashi Yuta、Torigoe Hidejiro、Sato Hiroki、Yoshioka Takahiro、Takeda Tatsuaki、Kurihara Eisuke、Ogoshi Yusuke、Yamamoto Hiromasa、Soh Junichi、Tomida Shuta、Toyooka Shinichi
    • Journal Title

      Molecular Cancer Research

      Volume: 17 Issue: 2 Pages: 499-507

    • DOI

      10.1158/1541-7786.mcr-18-0628

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K10784, KAKENHI-PROJECT-16H05431, KAKENHI-PROJECT-17K16608
  • [Journal Article] Application of amplicon-based targeted sequencing with the molecular barcoding system to detect uncommon minor EGFR mutations in patients with treatment-naive lung adenocarcinoma2019

    • Author(s)
      Namba Kei、Tomida Shuta、Matsubara Takehiro、Takahashi Yuta、Kurihara Eisuke、Ogoshi Yusuke、Yoshioka Takahiro、Takeda Tatsuaki、Torigoe Hidejiro、Sato Hiroki、Shien Kazuhiko、Yamamoto Hiromasa、Soh Junichi、Tsukuda Kazunori、Toyooka Shinichi
    • Journal Title

      BMC Cancer

      Volume: 19 Issue: 1 Pages: 1-9

    • DOI

      10.1186/s12885-019-5374-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10784, KAKENHI-PROJECT-16H05431
  • [Journal Article] Therapeutic potential of targeting S100A11 in malignant pleural mesothelioma2018

    • Author(s)
      Sato Hiroki、Sakaguchi Masakiyo、Yamamoto Hiromasa、Tomida Shuta、Aoe Keisuke、Shien Kazuhiko、Yoshioka Takahiro、Namba Kei、Torigoe Hidejiro、Soh Junichi、Tsukuda Kazunori、Tao Hiroyuki、Okabe Kazunori、Miyoshi Shinichiro、Pass Harvey I.、Toyooka Shinichi
    • Journal Title

      Oncogenesis

      Volume: 7 Issue: 1 Pages: 11-11

    • DOI

      10.1038/s41389-017-0017-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10784, KAKENHI-PUBLICLY-16H01574, KAKENHI-PROJECT-17H03577
  • [Journal Article] Combined inhibition of MEK and PI3K pathways overcomes acquired resistance to EGFR-TKIs in non-small cell lung cancer.2018

    • Author(s)
      Sato H, Yamamoto H, Sakaguchi M, Shien K, Tomida S, Shien T, Ikeda H, Hatono M, Torigoe H, Namba K, Yoshioka T, Kurihara E, Ogoshi Y, Takahashi Y, Soh J, Toyooka S
    • Journal Title

      Cancer Sci.

      Volume: 109 Issue: 10 Pages: 3183-3196

    • DOI

      10.1111/cas.13763

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H03577
  • [Journal Article] Therapeutic strategies for afatinib-resistant lung cancer harboring HER2 alterations2018

    • Author(s)
      Torigoe Hidejiro、Shien Kazuhiko、Takeda Tatsuaki、Yoshioka Takahiro、Namba Kei、Sato Hiroki、suzawa Ken、Yamamoto Hiromasa、Soh Junichi、Sakaguchi Masakiyo、Tomida Shuta、Tsukuda Kazunori、Miyoshi Shinichiro、Toyooka Shinichi
    • Journal Title

      Cancer Sci.

      Volume: - Issue: 5 Pages: 1493-1502

    • DOI

      10.1111/cas.13571

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H03577, KAKENHI-PROJECT-17K16608
  • [Journal Article] Tumor-suppressive effect of LRIG1, a negative regulator of ErbB, in non-small cell lung cancer harboring mutant EGFR2018

    • Author(s)
      Torigoe H, Yamamoto H, Sakaguchi M, Youyi C, Numba K, Sato H, Shien K, Soh J, Suzawa K, Tomida S, Tsukuda K, Miyoshi S, Toyooka S
    • Journal Title

      Carcinogenesis

      Volume: - Issue: 5 Pages: 719-727

    • DOI

      10.1093/carcin/bgy044

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H03577, KAKENHI-PROJECT-18K08783
  • [Journal Article] Newly developed anti-S100A8/A9 monoclonal antibody efficiently prevents lung tropic cancer metastasis.2018

    • Author(s)
      Kinoshita R, Sato H, Yamauchi A, Takahashi Y, Inoue Y, Sumardika IW, Chen Y, Tomonobu N, Araki K, Shien K, Tomida S, Torigoe H, Namba K, Kurihara E, Ogoshi Y, Murata H, Yamamoto KI, Futami J, Putranto EW, Ruma IMW, Yamamoto H, Soh J, Hibino T, Nishibori M, Kondo E, Toyooka S, Sakaguchi M.
    • Journal Title

      Int J Cancer.

      Volume: 印刷中 Issue: 2 Pages: 569-575

    • DOI

      10.1002/ijc.31982

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H03590, KAKENHI-PROJECT-16K08728, KAKENHI-PROJECT-16K19037, KAKENHI-PROJECT-19K07474, KAKENHI-PROJECT-19K07676, KAKENHI-PROJECT-17H03577, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-18K15320
  • [Journal Article] exSSSRs (extracellular S100 soil sensor receptors)-Fc fusion proteins work as prominent decoys to S100A8/A9-induced lung tropic cancer metastasis.2018

    • Author(s)
      Kinoshita R, Sato H, Yamauchi A, Takahashi Y, Inoue Y, Sumardika IW, Chen Y, Tomonobu N, Araki K, Shien K, Tomida S, Torigoe H, Namba K, Kurihara E, Ogoshi Y, Murata H, Yamamoto KI, Futami J, Putranto EW, Ruma IMW, Yamamoto H, Soh J, Hibino T, Nishibori M, Kondo E, Toyooka S, Sakaguchi M
    • Journal Title

      Int J Cancer.

      Volume: - Issue: 12 Pages: 3138-3145

    • DOI

      10.1002/ijc.31945

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H03577, KAKENHI-PROJECT-17H03590, KAKENHI-PROJECT-16K08728, KAKENHI-PROJECT-16K19037, KAKENHI-PROJECT-19K07474, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-18K15320
  • [Journal Article] b-1,3-galactosyl-O-glycosyl-glycoprotein b-1,6-N-acetylglucosaminyltransferase 3 Increases MCAM Stability, Which Enhances S100A8/A9-Mediated Cancer Motility.2017

    • Author(s)
      Sumardika I Wayan、Youyi Chen、Kondo Eisaku、Inoue Yusuke、Ruma I Made Winarsa、Murata Hitoshi、Kinoshita Rie、Yamamoto Ken-Ichi、Tomida Shuta、Shien Kazuhiko、Satoh Hiroki、Yamauchi Akira、Futami Junichiro、Putranto Endy Widya、Hibino Toshihiko、Toyooka Shinichi、Nishibori Masahiro、Sakaguchi Masakiyo
    • Journal Title

      Oncology Reserch

      Volume: in press Issue: 3 Pages: 431-444

    • DOI

      10.3727/096504017x15031557924123

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19037, KAKENHI-PROJECT-17H03577, KAKENHI-PROJECT-17H03590, KAKENHI-PROJECT-16K15245, KAKENHI-PROJECT-16K18440, KAKENHI-PROJECT-16K08728, KAKENHI-PROJECT-15K10201, KAKENHI-PROJECT-18K15320
  • [Journal Article] Distant Bystander Effect of REIC/DKK3 Gene Therapy Through Immune System Stimulation in Thoracic Malignancies2017

    • Author(s)
      Suzawa K, Shien K, Peng H, Sakaguchi M, Watanabe M, Hashida S, Maki Y, Yamamoto H, Tomida S, Soh J, Asano H, Tsukuda K, Nasu Y, Kumon H, Miyoshi S, Toyooka S.
    • Journal Title

      Anticancer Res

      Volume: 14 Pages: 301-307

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H03577
  • [Journal Article] Targeting the miR-200c/LIN28B axis in acquired EGFR-TKI resistance non-small cell lung cancer cells harboring EMT features.2017

    • Author(s)
      Sato H, Shien K, Tomida S, Okayasu K, Suzawa K, Hashida S, Torigoe H, Watanabe M, Yamamoto H, Soh J, Asano H, Tsukuda K, Miyoshi S, Toyooka S.
    • Journal Title

      Sci Rep.

      Volume: 7 Issue: 1 Pages: 40847-40847

    • DOI

      10.1038/srep40847

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-16H01574, KAKENHI-PROJECT-16H06988, KAKENHI-PROJECT-15K19935
  • [Journal Article] Acquisition of cancer stem cell-like properties in non-small cell lung cancer with acquired resistance to afatinib2015

    • Author(s)
      Shinsuke Hashida, Hiromasa Yamamoto, Kazuhiko Shien, Yuichiro Miyoshi, Tomoaki Ohtsuka, Ken Suzawa, Mototsugu Watanabe, Yuho Maki, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyooka
    • Journal Title

      Cancer Science

      Volume: 10 Issue: 10 Pages: 1377-1384

    • DOI

      10.1111/cas.12749

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25293302
  • [Journal Article] Hsp90 inhibitor NVP-AUY922 enhances the radiation sensitivity of lung cancer cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors.2015

    • Author(s)
      Hashida S, Yamamoto H, Shien K, Ohtsuka T, Suzawa K, Maki Y, Furukawa M, Soh J, Asano H, Tsukuda K, Miyoshi S, Kanazawa S, Toyooka S
    • Journal Title

      Oncology Reports

      Volume: 33 Issue: 3 Pages: 1499-1504

    • DOI

      10.3892/or.2015.3735

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24791462, KAKENHI-PROJECT-25293302
  • [Patent] 抗S100A8/A9抗体とその用途2019

    • Inventor(s)
      阪口政清、豊岡伸一、冨田秀太、枝園和彦、木下理恵 他
    • Industrial Property Rights Holder
      岡山大学、新潟大学、群馬大学、川崎学園
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Overseas
    • Data Source
      KAKENHI-PROJECT-17H03577
  • [Presentation] 空間マルチオミクス解析を駆使した肺がんドライバー遺伝子異常と微小環境との相互作用の解明2023

    • Author(s)
      枝園 和彦, 大亀 正義, 冨田 秀太, 松岡 篤志, 吉川 真生, 諏澤 憲, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 遠西 大輔, 豊岡 伸一
    • Organizer
      第64回日本肺癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K27687
  • [Presentation] 空間トランスクリプトーム解析による間質性肺炎合併肺癌の病態解明2023

    • Author(s)
      大亀 正義, 枝園 和彦, 松岡 篤志, 冨田 秀太, 東原 朋諒, 向原 史晃, 林 直宏. 土生 智大, 吉川 真生, 諏澤 憲, 山本 寛斉, 遠西 大輔, 豊岡 伸一
    • Organizer
      第64回日本肺癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K27687
  • [Presentation] Periostin secreted by cancer-associated fibroblasts promotes cancer progression and drug resistance in non-small cell lung cancer2023

    • Author(s)
      Mao Yoshikawa, Ken Suzawa, Fumiaki Takatsu, Tomohiro Habu, Kazuma Iwata, Masayoshi Ohki, Naoki Matsuda, Yin Min Zhu, Kazuhiko Shien, Hiromasa Yamamoto, Shinichi Toyooka
    • Organizer
      AACR ANNUAL MEETING 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K24421
  • [Presentation] ショットガンメタゲノム解析を用いた難治性肺がんマイクロバイオームの解明2023

    • Author(s)
      松岡篤志、枝園和彦、大亀正義、冨田秀太、田中真、橋本好平、諏澤憲、三好健太郎、山本寛斉、岡崎幹生、杉本誠一郎、遠西大輔、豊岡伸一
    • Organizer
      第64回日本肺癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K18317
  • [Presentation] Periostin secreted by cancer-associated fibroblast promotes cancer progression and drug resistance in non-small cell lung cancer2022

    • Author(s)
      Ken Suzawa, Shuta Tomida, Kazuhiko Shien, Hiromasa Yamamoto, and Shinichi Toyooka
    • Organizer
      第81回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-23K24421
  • [Presentation] Activation of AXL as a preclinical acquired resistance mechanism against osimertinib treatment in EGFR-mutant non-small cell lung cancer cells2019

    • Author(s)
      Kei Namba, Kazuhiko Shien, Yuta Takahashi, Hiroki Sato, Takahiro Yoshioka, Ken Suzawa, Hiromasa Yamamoto, Junichi Soh, Shuta Tomida, Shinichi Toyooka
    • Organizer
      AACR Annual Meeting 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05431
  • [Presentation] Clinicopathological characteristics of lung cancer patients with concomitant idiopathic pulmonary fibrosis2019

    • Author(s)
      Kota Araki, Kazuhiko Shien, Shunsaku Miyauchi, Akihiro Miura, Yuta Takahashi, Eisuke Kurihara, Yusuke Ogoshi, Kei Namba, Ken Suzawa, Hiromasa Yamamoto, Shuta Tomida, Junichi Soh, Masakiyo Sakaguchi, Shinichi Toyooka
    • Organizer
      AACR Annual Meeting 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K19581
  • [Presentation] Potent anti-tumor effect of ganetespib in acquired EGFR-TKI resistance NSCLC cells2018

    • Author(s)
      Eisuke Kurihara, Kazuhiko Shien, Hidejiro Torigoe, Yuta Takahashi, Yusuke Ogoshi, Takahiro Yoshioka, Kei Namba, Hiroki Sato, Hiromasa Yamamoto, Junichi Soh, Shinichi Toyooka
    • Organizer
      IASLC 19th World Conference on Lung Cancer
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16608
  • [Presentation] Acquired resistance mechanisms to afatinib in lung cancer cells harboring HER2 alterations2018

    • Author(s)
      Hidejiro Torigoe, Kazuhiko Shien, Tatsuaki Takeda, Takahiro Yoshioka, Kei Namba, Hiroki Sato, Ken Suzawa, Hiromasa Yamamoto, Junichi Soh, Masakiyo Sakaguchi, Shuta Tomida, Shinichiro Miyoshi, Shinichi Toyooka
    • Organizer
      AACR Annual Meeting 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16608
  • [Presentation] Tumor-suppressive effect of LRIG1 in non-small cell lung cancer harboring mutant EGFR2018

    • Author(s)
      鳥越英次郎、山本寛斎、阪口政清、難波圭、佐藤博紀、枝園和彦、諏澤憲、宗淳一、冨田秀太、佃和憲、三好新一郎、豊岡伸一
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-17H03577
  • [Presentation] Ganetespib demonstrates strong anti-tumor effect in acquired EGFR-TKI resistance NSCLC cells2018

    • Author(s)
      Eisuke Kurihara, Kazuhiko Shien, Hidejiro Torigoe, Yuta Takahashi, Yusuke Ogoshi, Takahiro Yoshioka, Kei Namba, Hiroki Sato, Hiromasa Yamamoto, Junichi Soh, Shinichi Toyooka
    • Organizer
      AACR Annual Meeting 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16608
  • [Presentation] 第3世代EGFR-TKI Osimertinib耐性肺癌細胞株における獲得耐性機構の解明2017

    • Author(s)
      難波 圭, 枝園 和彦, 吉岡 貴裕, 鳥越 英次郎, 佐藤 博紀, 山本 寛斉, 宗 淳一, 浅野 博昭, 佃 和憲, 豊岡 伸一
    • Organizer
      第58回日本肺癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K16608
  • [Presentation] HER2遺伝子異常肺癌に対するマルチキナーゼ阻害剤Afatinb耐性獲得機序の解明2017

    • Author(s)
      鳥越 英次郎, 枝園 和彦, 吉岡 貴裕, 難波 圭, 佐藤 博紀, 山本 寛斉, 宗 淳一, 浅野 博昭, 冨田 秀太, 佃 和憲, 豊岡 伸一
    • Organizer
      第58回日本肺癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K16608
  • [Presentation] Multiple acquired resistance mechanisms against third generation EGFR-TKI osimertinib in non-small cell lung cancer cells2017

    • Author(s)
      Kei Namba, Kazuhiko Shien, Hidejiro Torigoe, Hiroki Sato, Hiromasa Yamamoto, Junichi Soh, Kazunori Tsukuda, Shinichi Toyooka
    • Organizer
      第58回日本肺癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-16H05431
  • [Presentation] 分子標的薬への耐性機構の解明 肺がんにおける分子標的薬耐性メカニズムの解明2017

    • Author(s)
      枝園 和彦, 佐藤 博紀, 鳥越 英次郎, 難波 圭, 吉岡 貴裕, 山本 寛斉, 宗 淳一, 豊岡 伸一
    • Organizer
      第58回日本肺癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K16608
  • [Presentation] Detection of multiple low-frequency mutations by molecular-barcode sequencing2017

    • Author(s)
      Kei Namba, Shuta Tomida, Hidejiro Torigoe, Hiroki Sato, Kazuhiko Shien, Hiromasa Yamamoto, Junichi Soh, Kazunori Tsukuda, Shinichi Toyooka
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16H05431
  • [Presentation] Detection of multiple low-frequency mutations by molecular-barcode sequencing2016

    • Author(s)
      Kei Namba, Shuta Tomida, Kazuhiko Shien, Hidejiro Torigoe, Hiroki Sato, Hiromasa Yamamoto, Junichi Soh, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyooka
    • Organizer
      第57回日本肺癌学会総会
    • Place of Presentation
      福岡市
    • Year and Date
      2016-12-19
    • Data Source
      KAKENHI-PROJECT-16H05431
  • [Presentation] Targeting miR-200c/LIN28B axis in acquired EGFR-TKI resistance non-small cell lung cancer cells harboring EMT features2016

    • Author(s)
      Kazuhiko Shien, Hiroki Sato, Ken Suzawa, Shuta Tomida, Shinsuke Hashida, Hiromasa Yamamoto, Junichi Soh, Hidejiro Torigoe, Kei Namba, Mototsugu Watanabe, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyooka
    • Organizer
      IASCL World Congress on Lung Cancer 2016
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2016-12-04
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06988
  • [Presentation] Effect of Hsp90 inhibitor NVP-AUY922 with radiation on lung adenocarcinoma cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors2015

    • Author(s)
      Yuho Maki, Shinsuke Hashida, Hiromasa Yamamoto, Kazuhiko Shien, Tomoaki Ohtsuka, Ken Suzawa, Masashi Furukawa, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Susumu Kanazawa, Shinichi Toyooka
    • Organizer
      AACR 106th Annual Meeting
    • Place of Presentation
      米国
    • Year and Date
      2015-04-18
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25293302
  • [Presentation] The molecular characters of acquired resistant non-small cell lung cancer cells to afatinib2014

    • Author(s)
      Shinsuke Hashida, Shinichi Toyooka, Tomoaki Ohtsuka, Ken Suzawa, Kazuhiko Shien, Hiromasa Yamamoto, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda,Shinichiro Miyoshi
    • Organizer
      AACR Annual Meeting 2014
    • Place of Presentation
      San Diego, California, U.S.A
    • Data Source
      KAKENHI-PROJECT-25293302
  • [Presentation] The molecular characters of acquired resistant non-small cell lung cancer cells to afatinib

    • Author(s)
      Shinsuke Hashida, Shinichi Toyooka, Tomoaki Ohtsuka, Ken Suzawa, Kazuhiko Shien, Hiromasa Yamamoto, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyosh
    • Organizer
      AACR Annual Meeting 2014
    • Place of Presentation
      San Diego, California, U.S.A
    • Year and Date
      2014-04-05 – 2014-04-09
    • Data Source
      KAKENHI-PROJECT-25293302
  • 1.  Toyooka Shinichi (30397880)
    # of Collaborated Projects: 15 results
    # of Collaborated Products: 29 results
  • 2.  冨田 秀太 (10372111)
    # of Collaborated Projects: 13 results
    # of Collaborated Products: 23 results
  • 3.  YAMAMOTO Hiromasa (40467733)
    # of Collaborated Projects: 12 results
    # of Collaborated Products: 16 results
  • 4.  諏澤 憲 (90839713)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 7 results
  • 5.  SOH Junichi (90559890)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 12 results
  • 6.  Sakaguchi Masakiyo (70379840)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 10 results
  • 7.  冨樫 庸介 (80758326)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  遠西 大輔 (20825096)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 9.  MIYOSHI Shinichiro (00190827)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 10.  MATSUDA Fumihiko (50212220)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  TSUKUDA Kazunori (20346430)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 12.  ASANO Hiroaki (70534775)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 13.  山本 健一 (00711798)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 14.  木下 理恵 (40518297)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 15.  村田 等 (90579096)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 16.  枝園 忠彦 (30509451)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  本田 知之 (80402676)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  土生 智大 (00974859)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  匹田 貴夫 (00437005)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  中山 雅敬 (70740918)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  中田 英二 (10649304)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  岡崎 幹生 (50467750)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 23.  細野 祥之 (60820363)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  大橋 圭明 (60729193)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  山中 玲子 (00379760)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  伊達 慶一 (30974860)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  SATO Hiroki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 28.  SUGIMOTO Seiichiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  KONDO Eisaku
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 30.  村上 孝
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  橘 逸勢
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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