NAKASHIMA Izumi 中島泉

Researcher Number	40022826
Affiliation (based on the past Project Information) *help	2006: Chubu University, Life Health Sciences, Professor 2005: 中部大学, 生命健康科学研究所, 教授 2002 – 2003: 名古屋大学, 大学院・医学系研究科, 教授 2001: Graduate School of Medicine, Nagoya University, Professor, 大学院・医学研究科, 教授 1993 – 2000: 名古屋大学, 医学部, 教授 1989 – 1991: 名古屋大学, 医学部, 教授
Review Section/Research Field	Principal Investigator Biological Sciences / 広領域 / Dermatology Except Principal Investigator General surgery / Biological Sciences / Immunology / Risk sciences of radiation/Chemicals / Immunology / Experimental pathology / Pathological medical chemistry / 広領域
Keywords	Principal Investigator RET / トランスジェニックマウス / メラノーマ / 酸化ストレス / がん遺伝子 / 紫外線 / MKK6- / RETがん遺伝子 / グリチルリチン / 十全大補湯 … More / 細胞傷害性Tリンパ球 / アメリカ / 国際情報交換 / チロシンキナーゼ / システイン残基 / 腫瘍免疫 / メラノ-マ / negative selection / -mouse / apoptosis / reft / T-lymphocyte / redox / Tyrosine kinase / ネガテイブセレクション / -マウス / アポトーシス / ラフト / T細胞 / レドックス / チロシンナーゼ / anti-oxidants / oxidative stress / melanocytic tumors / malignant melanoma / malignant / ultraviolet / RET-transgenic mice / RET oncogene / 悪性転化 / スーパー活性化 / Rfp-Ret / 抗酸化物質 / メラノサイト系腫瘍 / 悪性黒色腫 / RET-トランスジェニックマウス / クルクミン / 漢方 / 腫瘍増殖抑制 / 免疫促進 / 重金属ストレス / 抗c-Kit抗体 / Wvマウス / Wv / c-Kit / メラニン産生 / S-S結合 / 酸化還元 / 2量体 / チロシンリン酸化 / Srcキナーゼ / スルフヒドリル基 / シグナル伝達 / 一酸化窒素 / 塩化第2水銀 / 重金属イオン / 免疫遺伝子治療 / TNFレセプター / がん遺伝子ret / 発がん制御 / 前がん / プレ-Bリンホマ / メラノ-シス / retがん遺伝子 / 免疫反応 / がん発生 … More Except Principal Investigator トランスジェニックマウス / 異種移植 / CD122 / 制御性T細胞 / メラノーマ / CXCR3 / EAE / RET / チロシンキナーゼ / TIMP / MMP / トランスジェニック動物 / トランスジェニックブタ / 異種抗原 / Complement regulatory factor / 遺伝子操作 / 補体制御因子 / CD8 / サイトカイン / キラーT細胞 / がん抗原 / CD8^+ T cells / Regulatory T cells / Immune regulation / CD8^+T細胞 / 免疫制御 / superactivation / cancer / superoxide dismutase / tyrosine kinase / arsenic / ゼラチン分解酵素 / ERK / 癌遺伝子産物 / スーパーオキサイド / アミノ酸 / 発癌機構 / スーパー活性化 / 癌 / スーパーオキサイドディスミュターゼ / ヒ素 / Chemokine / Gene-targeted mice / Functional assay / Gene cloning / Cytokine / Survival factor / Lymph node-derived stromal cells / Resting T cells / cDNAクローニング / リンパ節ストロマ細胞 / 遺伝子ターゲティング / T細胞生存因子 / ケモカイン / ノックアウトマウス / 機能的アッセイ / 遺伝子クローニング / 生存因子 / リンパ節由来ストロマ細胞 / 静止期T細胞 / malignant melanoma / medullary thyroid carcinoma / RET gene / metastasis / transgenic mouse / MMP-9 / ret遺伝子 / MEN2A / 甲状腺髄様癌 / 悪性黒色腫 / RET遺伝子 / 癌転移 / Fucosyltransferases / Galactosylransferases / Antigens, Heterophile / Complement Inactivators / Animals, Transgenic / Transplantation, Heterologous / α1.2FT / α1.3GT / ノックアウト動物 / 遺伝子制御 / フコシルトランスフェラーゼ / ガラクトシルトランスフェラーゼ / 補体不活化因子 / Gene engineering / Xenoantigen / Transgenic pig / Xenotransplantaion / 補体制御因子遺伝子 / Hyperacute rejection / Xenoantibody production / Gene Engineering / Xenotransplantation / marzinal zone / gene engineering / 超急性拒絶反応 / 抗体産生 / Polymorphism of oligosac-charides / Oligosaccharide structure / Glycocojugates, / 糖鎖抗原 / モノクロ-ナル抗体 / 糖鎖と病態 / 糖鎖の多様性 / 糖鎖構造 / 複合糖質 / PNH / Hydrophobic Anchor / Phosphatidylinositol / Membranous Proteins / PI Anchor / PIアンカ- / 発作性夜間血色素尿症 / 疎水性アンカ- / ホスファチジルイノシト-ル / 膜蛋白質 / PI:アンカ- / インターロイキン(IL)-10 / インターフェロン(IFN)-γ / インターロイキン-10 / T細胞受容体 / MHCクラスI / インターフェロン-γ / IL-2受容体 / CD8陽性 / 細胞表面マーカー / ナイーブT細胞 / 試験管内培養系 / T細胞サブセット / 腫瘍発生 / 細胞障害性T細胞 / 十全大補湯 / 遺伝子リンケージスタディ / Retトランスジェニックマウス / 遺伝子型解析 / 発がん感受性 / Retがん遺伝子 / ペプチドモチーフ / クラスIMHC / T細胞レパトア / TIL / 補助シグナル / T細胞エピトープ / MHCペプチド / 免疫寛容 / トレランス / 養子免疫療法 / IL-12 / NKT細胞 / ドレランス / がん免疫 / CTL / MHC結合ペプチド Less

CD8^+CD122^+制御性T細胞による免疫制御機構の解明
- Principal Investigator
  
  鈴木治彦
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
Clarification of the role of CD8^+CD122^+ regulatory T cells in vivo and development of their clinical applications
- Principal Investigator
  
  SUZUKI Haruhiko
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Nagoya University
Mechanism of a arsenic-mediated cancer development
- Principal Investigator
  
  KATO Masashi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Chubu University
メラノーマ自然発症マウスを用いたCTL免疫誘導促進性抗がん物質の新規探索法の開発Principal Investigator
- Principal Investigator
  
  中島泉
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
メラノーマ自然発症トランスジェニックモデルを用いたCTL誘導性抗がん物質の探索Principal Investigator
- Principal Investigator
  
  中島泉
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
Study on redox-linked regulatory mechanism of intracellular signal transduction for differentiation and death of T lymphocytesPrincipal Investigator
- Principal Investigator
  
  NAKASHIMA Izumi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  広領域
- Research Institution
  Nagoya University
制御性T細胞の発がん制御への関わりとその機構に関する研究
- Principal Investigator
  
  鈴木治彦
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
がん遺伝子産物チロシンキナーゼの酸化的構造修飾による高度活性化の機序と意義Principal Investigator
- Principal Investigator
  
  中島泉
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
Retがん遺伝子誘発メラノーマの発がん感受性を決定する遺伝子の検索
- Principal Investigator
  
  鈴木治彦
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
増殖因子受容体がん遺伝子産物の酸化的構造修飾による活性化の機序と意義Principal Investigator
- Principal Investigator
  
  中島泉
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
トランスジェニックマウスを用いたc-Kit分子を標的とした悪性黒色腫治療Principal Investigator
- Principal Investigator
  
  中島泉
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
Identification of factors sftpporting the survival of mature T lymphocytes
- Principal Investigator
  
  SUZUKI Haruhiko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Nagoya University
Analysis of the mechanism of ultraviolet irradiation-mediated induction skin malignant melanomaPrincipal Investigator
- Principal Investigator
  
  NAKASHIMA Izumi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Nagoya University
Retがん遺伝子誘発メラノーマの発がん感受性を決定する遺伝子要因
- Principal Investigator
  
  鈴木治彦
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Nagoya University
がん免疫寛容のメカニズムとその制御
- Principal Investigator
  
  谷口克
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Chiba University
SH基修飾性化学物質を探索子とするストレスシグナル伝達カスケードの解析Principal Investigator
- Principal Investigator
  
  中島泉
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya University
Analysis of molecular mechanisms of cancer metastasis using transgenic mice
- Principal Investigator
  
  TAKAHASHI Masahide
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagoya University
Research on xenotransplantation using genetic engineering
- Principal Investigator
  
  TAKAGI Hiroshi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General surgery
- Research Institution
  Nagoya University
Establishment of Transgenic Pig for Organ Xenotransplantation
- Principal Investigator
  
  TAKAGI Hiroshi
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Nagoya University
がん抗原分子と免疫認識
- Principal Investigator
  
  谷口克
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Chiba University
トランスジェニックマウス発がん個体において有効な免疫遺伝子治療法開発のための基礎的研究Principal Investigator
- Principal Investigator
  
  中島泉
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Nagoya University
Study of Xenotransplatation Using Gene Engineering Technique
- Principal Investigator
  
  TAKAGI Hiroshi
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Nagoya University
がん遺伝子トランスジェニックマウス前がん段階の免疫調節による発がんの制御Principal Investigator
- Principal Investigator
  
  中島泉
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Nagoya University
メラノ-マ好発系トランスジェニックマウスにおけるがん発生初期段階の免疫反応の解析Principal Investigator
- Principal Investigator
  
  中島泉
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Nagoya University
The Biological Significance of PI as the Hydrophobic Anchor for Membranous Proteins
- Principal Investigator
  
  IKEZAWA Hiroh
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  広領域
- Research Institution
  Nagoya City University
Polymorphism of oligosaccharide structure in glycoconjugaates
- Principal Investigator
  
  TAKAHASHI Noriko
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nagoya City University College of Nursing

All 2006 2005

All Journal Article Book

[Book] 免疫実験法ハンドブック2006
- Author(s)
  中島泉 (編)
- Total Pages
  358
- Publisher
  名古屋大学出版会
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390142
[Book] 免疫学実験法ハンドブック2006
- Author(s)
  中島, 加藤ら[中島泉編]
- Total Pages
  358
- Publisher
  名古屋大学出版会
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16310037
[Book] Handbook of Experimental Immunology2006
- Author(s)
  Izumi Nakashima (editor)
- Total Pages
  358
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390142
[Book] Prog Protein Res2005
- Author(s)
  Nakashima I, Kato M (5/6), et al.
- Publisher
  MXXCW motif as a potential initiator of protein tyrosine kinases.(印刷中)
- Data Source
  KAKENHI-PROJECT-16310037
[Journal Article] A PKC-mediated backup mechanism of the MXXCW motif-linked switch for initiating tyrosine kinase activities2006
- Author(s)
  Takeda K, Kawamoto Y, Okuno Y, Kato M, Takahashi M, Suzuki H, Isobe K, Nakashima I
- Journal Title
  
  FEBS Letter 580
  
  Pages: 839-843
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390142
[Journal Article] A PKC-mediated backup mechanism of the MXXCW motif-linked switch for initiating tyrosine kinase activities.2006
- Author(s)
  Takeda K, Kawamoto Y, Okuno Y, Kato M, Takahashi M, Suzuki H, Isobe K, Nakashima I.
- Journal Title
  
  FEBS Letter 580(3)
  
  Pages: 839-843
- Data Source
  KAKENHI-PROJECT-17390142
[Journal Article] A PKC-mediated backup mechanism of the MXXCW motif-linked switch for initiating tyrosine kinase activities2006
- Author(s)
  Takeda K, Kawamoto Y, Okuno Y, Kato M, Takahashi M, Suzuki H. Isobe K, Nakashima I
- Journal Title
  
  FEBS Letter 580
  
  Pages: 839-843
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390142
[Journal Article] Redox control of catalytic activities of membrane-associated protein.2005
- Author(s)
  Nakashima I, Kato M (5/6), et al.
- Journal Title
  
  Arch Biochem Biophys 434
  
  Pages: 3-10
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16310037
[Journal Article] Redox control of catalytic activities of membrane-associated protein2005
- Author(s)
  Nakashima I, Kato M (6人中5番目), et al.
- Journal Title
  
  Arch Biochem Biophys
  
  Volume: 434 Pages: 3-10
- Data Source
  KAKENHI-PROJECT-16310037
[Journal Article] Redox control of catalytic activities of membrane-associated protein tyrosine kinases.2005
- Author(s)
  Nakashima I
- Journal Title
  
  Arch Biochem Biophys
  
  Volume: 434 Pages: 3-10
- Data Source
  KAKENHI-PROJECT-16310037
[Journal Article] Redox control of catalytic activities of membrane-associated protein2005
- Author(s)
  Nakashima I, Kato M (5/6), et al.
- Journal Title
  
  Arch Biochem Biophys 434
  
  Pages: 3-10
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16310037

1. SUZUKI Haruhiko (90283431)

# of Collaborated Projects: 14 results

# of Collaborated Products: 3 results
2. KATO Masashi (10281073)

# of Collaborated Projects: 6 results

# of Collaborated Products: 5 results
3. ISOBE K (20151441)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. TAKEDA Kozue (80345884)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
5. OKADA Hidechika (30160683)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. TAKAGI Hiroshi (70154755)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. HAYASHI S (30218573)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. 谷口克 (80110310)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 佐藤昇志 (50158937)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 古川鋼一 (80211530)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 栗林景容 (10064578)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. IKEZAWA Hiroh (40080163)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TAKESUE Yoshiki (50023651)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TOMITA Motowo (30102370)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. IKEHARA Yukio (70037612)

# of Collaborated Projects: 1 results

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16. KITO Makoto (60027183)

# of Collaborated Projects: 1 results

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17. TAKAHASHI Noriko (90079989)

# of Collaborated Projects: 1 results

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18. KANNAGI Reiji (80161389)

# of Collaborated Projects: 1 results

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19. ISHIHARA Hideko (90080192)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. HAYASHI Kyozo (00029935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. ARATA Yoji (40011499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. YOKOYAMA Itsuo (60240206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. KITO Junzo (60022802)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. MURAMATSU Takashi (00030891)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. TAKAHASHI Masahide (40183446)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. IWASHITA Toshihide (00283432)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. KAMBAYASHI Yasuhiro (20345630)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. OGINO Keiki (70204104)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. HAYAKAWA Akemi (70412377)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 岩本隆司 (60223426)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 長瀬文彦 (10109340)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 江浦正郎 (60193984)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 西村孝司 (30143001)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 藤原大美 (70116094)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 奥村康 (50009700)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 西村泰治 (10156119)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 石川哮 (00009143)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 高橋利忠 (00124529)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. 渡辺武 (40028684)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. 浅井直也 (80273233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. 小林章二

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. KOBAYASHI S

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NAKASHIMA Izumi 中島 泉

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メラノーマ自然発症マウスを用いたCTL免疫誘導促進性抗がん物質の新規探索法の開発Principal Investigator

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メラノーマ自然発症トランスジェニックモデルを用いたCTL誘導性抗がん物質の探索Principal Investigator

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Study on redox-linked regulatory mechanism of intracellular signal transduction for differentiation and death of T lymphocytesPrincipal Investigator

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がん遺伝子産物チロシンキナーゼの酸化的構造修飾による高度活性化の機序と意義Principal Investigator

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増殖因子受容体がん遺伝子産物の酸化的構造修飾による活性化の機序と意義Principal Investigator

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トランスジェニックマウスを用いたc-Kit分子を標的とした悪性黒色腫治療Principal Investigator

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Analysis of the mechanism of ultraviolet irradiation-mediated induction skin malignant melanomaPrincipal Investigator

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NAKASHIMA Izumi 中島泉