seino yutaka 清野裕

… Alternative Names

清野裕セイノユタカ

SEINO Yutaka 清野裕

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Researcher Number	40030986
Other IDs
External Links
Affiliation (Current)	2025: 株式会社関西メディカルネット(関西電力医学研究所), 関西電力医学研究所, 所長 2025: 京都大学, 医学研究科, 名誉教授
Affiliation (based on the past Project Information) *help	2017 – 2019: 株式会社関西メディカルネット(関西電力医学研究所), 関西電力医学研究所, 所長 2007 – 2011: Kyoto University, 医学研究科, 名誉教授 2004: Kyoto University, Graduate School of Medicine and Faculty of Medicine, emeritus Professor, 医学研究科, 名誉教授 1995 – 2003: Professor, Dept.of Metab.and Clin.Nutr.Kyoto University, School of Medicine,, 医学研究科, 教授 1999 – 2002: 京都大学, 大学院・医学研究科, 教授 … More 1998: 京都大学, 大学院医学研究科, 教授 1997: 京都大学, 大学院・医学研究科, 教授 1995: 京都大学, 医科研究科, 教授 1986 – 1994: 京都大学, 医学部, 助教授 1986: Division of Metabolism and Clinical Nutrition, Kyoto University, Faculty of Medicine, Associate Professor, 医学部, 助教授 Less
Review Section/Research Field	Principal Investigator 内分泌・代謝学 / Metabolomics / Metabolomics Except Principal Investigator 内分泌・代謝学 / Clinical psychology / General surgery
Keywords	Principal Investigator 膵β細胞 / 糖尿病 / GIP / GLUT2 / 糖輸送担体 / GLP-1 / インクレチン / SSTR2 / cAMP / ソマトスタチン … More / PCR-SSCP / 転写調節 / Tet expression system / ATF2 / PKA / CREM / oral hypoglycemic agents / intracellular calcium / voltage-dependent Ca^<2+> channel / patch clamp technique / diabetes mellitus / insulin secretion / pancreatic beta cells / パッチクランプ法 / インスリン分泌 / Pancreatic beta cell / ブドウ糖 / 筋肉 / 肝 / ラ氏島 / 糖輸送担体(GLUT) / アポトーシス / β細胞 / ERストレス / 糖質代謝異常 / エネルギー / MAPキナーゼ / オクトレオチド / ルシフェラーゼ・アッセイ / 細胞内カルシウム濃度 / 電位依存性カルシウムチャネル / インスリン / グルコース / クローニング / ソマトスタチン受容体 / Obesity / Non cholinergic neuron / Cholinergic neuron / Vagus / Somatostatin / 膵 / 交感神経 / 迷走神経 / osteoblast / adipocyte / incretin / 骨芽細胞 / 脂肪細胞 / Proliferation and differentiation / Target gene / Transcription factor / SAGE / pancreatic β-cell line / Tet Expression System / 膵β細胞の発生と機能 / 膵Β細胞株 / 分化・増殖 / 標的遺伝子 / 転写因子 / SAGE法 / 膵β細胞株 / CaMK TV / glucose-responsive / insulin gene / CRE-BPl / calmodulin-dependent protein kinase IV / カルシウムチャネル / TBP / p300 / CBP / CRE-BP1 / CRE / CaMKIV / グルコース応答性 / インスリン遺伝子 / Pancreatic beta cells / スルフォニルウレア受容体 / ATP感受性K^+チャネル / GIP Receptor / Voltage-dependent Calcium Channel / Glucose Transporter / Mutation / Gene / Diabetes Mellitus / PCR-SSCP法 / GIP受容体 / 電位依存性カルシウム・チャネル / 変異 / 遺伝子 / バッチクランプ法 / 電位依存性Ca^<2+>チャネル / 経口血糖降下剤 / Glucose / Luciferase assay / CAT assay / Hepatocyte / Transcription / SSTR / 転写制御 / GULT2 / CATアッセイ / 肝細胞 / sscp / insulin / pancreatic beta cell / diabetes / glucose transporter / 遺伝子発見 / SSCP / nuscle / liver / islet / mRNA / gene expression / glucose transporter (GLUT) / obesity / Diabetes mellitus / 低インスリン血症 / 高インスリン血症 / 高血糖 / メッセンジャ-(m)RNA / 遺伝子発現 / 肥満 / XBP-1 / Bip / CHOP / 秋田マウス / 再生 / 細胞増殖 / 細胞増殖抑制 / 細胞内情報伝達系 / SSTR1 / G蛋白質 / ATP感受性カリウムチャネル / NIDDM / HepG2 / フット・プリント法 / ゲルシフト・アッセイ / GLUT1 / α_1サブユニット / 多型性 / 遺伝子構造 / チャネル活性 / DNase Iフット・プリント法 / ゲルシフトアッセイ / GRP / ルシフェラーゼアッセイ / HepG2細胞 / 遺伝子転写調節領域 / 赤血球型糖輸送担体 / インターロイキン / 甲状腺癌 / 消化器癌 / ソマトスタチンレセプター / 脳腫瘍 / 糠輸送担体 / がん / シンチグラフィー / ソマトスタチンアナログ / RT-PCR / 結合特性 / 内分泌腫瘍 … More Except Principal Investigator 糖尿病 / インスリン分泌 / ATP感受性K^+チャネル / パッチクランプ法 / 膵β細胞 / インスリン / 電位依存性Ca^<2+>チャネル / ブドウ糖 / 血圧 / 糖輸送担体 / ANP / Patch-clamp technique / Diabetes mellitus / 細胞内カルシウム濃度 / cyclic AMP / GIP / POMC / CNP / BNP / Leumorphin / バソプレッシン / ロイモルフィン / オピオイドペプチド / SNPs / diabetes mellitus / 細胞内Ca^<2+>濃度 / ATP-sensitive K^+ channels / Insulin secretion / Pancreatic beta-cells / insulin / Intracellular calcium concentration / 細胞内カルシウム / 細胞内情報伝達系 / insulin gene / cAMP / GLUT / インスリン遺伝子 / 成長因子 / 遺伝子発現 / 甲状腺がん / 肝がん / 膵内分泌腫瘍 / 成長ホルモン / 甲状腺癌 / 単クロ-ン抗体 / 膵癌 / 肝癌 / 療養指導 / ライフサイクル / 糖尿病患者の心理的特徴 / 心理的介入 / ライフタスク / 高年クライシス / 中年クライシス / ウェールビーイング / ストレス / こころの健康度 / ⑦療養指導教育プログラム / ⑥高齢期糖尿病の療養指導教育 / ⑤心理介入 / ④ライフサイクル課題と危機 / ③ウエルビーイング / ②ストレス / ①心の健康度測定スケール「BUKK」 / Motilin / Cytokines / インターロイキン / 視床下部 / 神経内分泌学 / CRF / ACTH / POMC 遺伝子 / モチリン / サイトカイン / leumorphin / Phospholipase C / GTP-Binding Protein / Pancreatic Islet / Insulin Secretion / 刺激伝達機構 / Inosital1,4,5-trisphosphate / Isiet-Activating protein(IAP) / Cキナーゼ / イノシトールリン酸 / GTP結合蛋白 / ホスホリパーゼC / 分泌 / Drinking / Vasopressin / Blood Pressure / Pituitary Hormones / Opioid Peptides / 性週期 / 抗利尿ホルモン / 飲水行動 / ゴナドトロピン / オピオイドペプタイド / プロラクチン / 中枢性血圧調節 / 飲水 / 下垂体ホルモン / Type 1 diabetes / GMP facility / Non-heart-beating donor / Islet isolation method / Living donor / Living donor islet transplantation / 二層法膵保存 / 膵管保護 / ブタ膵島 / ISO9001 / GMP / 膵島移植 / インスリン依存状態糖尿病 / 膵島分離技術 / 生体膵島移埴 / 1型糖尿病 / GMP施設 / 心臓死ドナー / 膵島移植分離技術 / 生体ドナー / 生体膵島移植 / association analysis / gene structure / gene function / genetic analysis / multifactorial disease / 多遺伝子疾患 / 原因遺伝子解析 / 相関解析 / 遺伝子構造 / 遺伝子機能 / 遺伝子解析 / 多因子疾患 / voltage-dependent calcium channel / ATP-sensitive KィイD1+ィエD1 channel / calmodulin / SNARE protcins / intraccllular calcium / insulin secrction / 電位依存性CA^<2+>チャネル / バッチクランプ法 / 電位依存性Ca_<2+>チャネル / サイクリックAMP / カルモジュリン / SNARE蛋白群 / Intracellular Ca^<2+> / Voltage-dependent Ca^<2+> channels / Voltage-dependnet Ca^<2+> channels / 電位依存性Ca^<2+>チャンネル / ATP感受性K^+チャンネル / パッチランプ法 / CAMP / CRE (CAMP response element) / transcription / CRE(cyclic AMP rospone element) / CRE(cyclic AMP response elenent) / cAMP. / CRE(cyclic AMP response element) / 転写 / Voltage-dependent Ca^<2+> channel / ATP-sensitive K^+ channel / Intracellular signal transduction system / イオンチャネル / 電位依存Ca_<2+>チャネル / ATP感受K_+チャネル / プロモ-タ-領域 / エンハンサ-領域 / CAT活性 / HeLa / Hep G2 / CAT アッセイ / Glut 1 / 糖輸送担体(Glut) / 自律神経 / 糖代謝 / 膵酵素 / 食欲 / 味覚 / 単クローン抗体 / ブドウ糖輸送担体 / EGFレセプター / スルフォニルウレア受容体 / スルフォルニルウレア受容体 / 細胞内ブドウ糖代謝 / I変換酵素 / アンジオテンシン / 経口寛容 / サポニン / ソマスタチン / グルコキメーゼ / IGFI / GLUT5 / コレステロール / コラーゲン / 関節リュウマチ / 神経細胞 / アレルギー / 血圧降下作用 / ソマトスタチン / 脂肪細胞 / カゼイン / モノクロメ-ル抗体 / 免疫組織化学 / ELISA / 膵がん / IGF / 増殖因子レセプタ- / インスリン作用 / 摂食 / 嗅覚・味覚 / 食品成分 / インスリン様成長因子 / インスリン受容体 / 食欲促進物質 / 嗅覚応答 / 味覚応答 Less

Survey research on psycliological issues of the individuals with diavetes and the construction of an educational medical care program
- Principal Investigator
  
  Higashiyama Hiroko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical psychology
- Research Institution
  株式会社関西メディカルネット(関西電力医学研究所)
Investigation for intracellular mechanisms of pancreatic-cell proliferation and anti-apoptotic effect of incretinPrincipal Investigator
- Principal Investigator
  
  SEINO Yutaka
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kyoto University
Effect of incretin on beta cell proliferation and prevention of diabetesPrincipal Investigator
- Principal Investigator
  
  SEINO Yutaka
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kyoto University
Gut-peptides regulate metabolism in whole body.Principal Investigator
- Principal Investigator
  
  HOSOKAWA Masaya, 清野裕
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Kyoto University
Living donor islet transplantation for the treatment of sever diabetes
- Principal Investigator
  
  MATSUMOTO Shinichi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  KYOTO UNIVERSITY
Analysis of transcriptional network in pancreatic β-cellsPrincipal Investigator
- Principal Investigator
  
  SEINO Yutaka
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  KYOTO UNIVERSITY
Comprehensive Analysis of Genetic Factors in Diabetes Mellitus
- Principal Investigator
  
  SEINO Susumu
- Project Period (FY)
  1998 – 2002
- Research Category
  
  Grant-in-Aid for Creative Scientific Research
- Research Institution
  Chiba University
膵β細胞SUレセプターとATP感受性K+チャネルの機能的連関と糖尿病での異常
- Principal Investigator
  
  石田均
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
ソマトスタチンによる腫瘍増殖抑制機構の解析Principal Investigator
- Principal Investigator
  
  清野裕
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyoto University
Characterizetion of glucose-induced signal transduction and its impairment in type 2 diabetePrincipal Investigator
- Principal Investigator
  
  SEINO Yutaka
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyoto University
Molecular physiological and biological studies on the mechanismof impaired glucose-induced insulin secretion in diabetes mellitus
- Principal Investigator
  
  ISHIDA Hitoshi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyorin University
  Kyoto University
膵β細胞ATP感受性K^+チャネルとSUレセプターの機能協関と糖尿病における異常
- Principal Investigator
  
  石田均
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
ソマトスタチンによる抗腫瘍効果の分子機構に関する研究Principal Investigator
- Principal Investigator
  
  清野裕
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyoto University
Development of new hypoglycemic agents with a novel insulinotropic mechanism and their clinical appkicatiorPrincipal Investigator
- Principal Investigator
  
  SEINO Yutaka
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY
膵β細胞でのATP感受性K^+チャネルと糖輸送担体の機能協関と糖尿病における異常
- Principal Investigator
  
  石田均
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
糖尿病発症に関与する膵β細胞イオンチャネルの分子生物学的研究Principal Investigator
- Principal Investigator
  
  清野裕
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyoto University
A study on the beta-Cell glucose sensors in insulin secretion : The relationship between dysfunction of glucose sensors and development of diabetes mellitusPrincipal Investigator
- Principal Investigator
  
  SEINO Yutaka
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  KYOTO UNIVERSITY
Physiological and molecular biological studies on the pathogenesis of impaired insulin secretion in diabetes mellitus.
- Principal Investigator
  
  ISHIDA Hitoshi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY
食品の生体調節因子の解析と設計
- Principal Investigator
  
  上野川修一
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
グルコース飢餓における赤血球型糖輸送担体(GLUT1)発現増強機構の解析Principal Investigator
- Principal Investigator
  
  清野裕
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
カルシウムチャネル活性化に伴う神経細胞死に関する研究Principal Investigator
- Principal Investigator
  
  清野裕
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
高親和性糖輸送担体の発現抑制による細胞増殖抑制作用に関する研究Principal Investigator
- Principal Investigator
  
  清野裕
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
Development of new hypoglycemic agents with a novel insulinotropic mechanism and their clinical applicationPrincipal Investigator
- Principal Investigator
  
  SEINO Yutaka
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY
がんの産生する蛋白の診断への応用に関する研究Principal Investigator
- Principal Investigator
  
  清野裕
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
The analysis of transcriptional regulation in a series of glucose responsive genes.Principal Investigator
- Principal Investigator
  
  SEINO Yutaka
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY
Studies on the mechanism of transcription regulation of insulin gene in pancreatic B cell
- Principal Investigator
  
  TSUDA Kinsuke
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY
Physiological and molecular biological studies on functional alterations in ion channels of pancreatic beta cells in diabetes mellitus.
- Principal Investigator
  
  ISHIDA Hitoshi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY
インスリン分泌における糖輸送の分子機構Principal Investigator
- Principal Investigator
  
  清野裕
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyoto University
Roles of various types of glucose transporter gene in diabetes mellitusPrincipal Investigator
- Principal Investigator
  
  SEINO Yutaka, 井村裕夫
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kyoto University
Physiological and molecular biological studies on altered function of the intracellular signal transduction system in pancreatic beta cells of diabetes mellitus.
- Principal Investigator
  
  ISHIDA Hitoshi
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY
がんの産生する蛋白の診断への応用に関する研究
- Principal Investigator
  
  井村裕夫
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
がんの産生する蛋白の診断への応用に関する研究
- Principal Investigator
  
  井村裕夫
- Project Period (FY)
  1990 – 1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
Studies on molecular mechanism of etiology of diabetes mellitusPrincipal Investigator
- Principal Investigator
  
  SEINO Yutaka
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyoto University
Studies on negative regulation of insulin gene expression in non-pancreatic cells
- Principal Investigator
  
  TSUDA Kinsuke
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY
生体における食品成分の受容・応答の機作
- Principal Investigator
  
  井村裕夫
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
生体における食品成分の受容・応答の機作
- Principal Investigator
  
  井村裕夫
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
生体における食品成分の受容・応答の機作
- Principal Investigator
  
  井村裕夫
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
Grant-in-Aid for Scientific Research (A)
- Principal Investigator
  
  IMURA H
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyoto University
腫瘍におけるホルモンなどの活性物質の産生機構とその診断・治療への応用
- Principal Investigator
  
  IMURA Hiroo
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
腫瘍におけるホルモンなどの活性物質の産生とその診断・治療への応用
- Principal Investigator
  
  井村裕夫
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
The Role and Activation Mechanism of Phospholipase C in Insulin Secretion
- Principal Investigator
  
  TAMINATO Tomohiko
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyoto University
Physiological and clinical significance of opioids and related peptides
- Principal Investigator
  
  IMURA Hiroo
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyoto University
The role of somatostatin in pathophysiology of obesity and diabetes mellitusPrincipal Investigator
- Principal Investigator
  
  SEINO Yutaka
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyoto University

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[Journal Article] Immunoassays for incretin hormones GIP and GLP-12011
- Author(s)
  矢部大介、清野裕
- Journal Title
  
  日本臨床
  
  Volume: 69 Pages: 946-950
- NAID
  40018816647
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] The effect of gastric inhibitory polypeptide on intestinal glucose absorption and intestinal motility in mice2011
- Author(s)
  Ogawa E, Yamane S, Toyoda K, Seino Y, Inagaki N, et al.
- Journal Title
  
  Biochemical Biophysical Research Communication
  
  Volume: 404 Pages: 115-120
- NAID
  120002737766
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] The history of incretin hormones.2011
- Author(s)
  Yabe D, Seino Y
- Journal Title
  
  日本臨床
  
  Volume: 69 Pages: 755-760
- NAID
  40018816616
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] Understanding the incretin effect2011
- Author(s)
  Seino Y.
- Journal Title
  
  Journal of Endocrinology and Metabolism
  
  Volume: 96 Issue: 4 Pages: 934-935
- DOI
  10.1210/jc.2011-0329
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] The history of incretin hormones2011
- Author(s)
  矢部大介、清野裕
- Journal Title
  
  日本臨床
  
  Volume: 69 Pages: 755-760
- NAID
  40018816616
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] GLP-1 receptor agonist attenuates ER stress-mediatedβ-cell damage in Akita mice2011
- Author(s)
  Yamane S, Hamamoto Y, Toyoda K, Seino Y Inagaki N, et al.
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 2 Issue: 2 Pages: 79-154
- DOI
  10.1111/j.2040-1124.2010.00075.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132, KAKENHI-PROJECT-22590975
[Journal Article] Two incretin hormones GLP-1 and GIP : Comparison of their actions in insulin secretion and β cell preservation2011
- Author(s)
  Yabe D, Seino Y
- Journal Title
  
  Progress in Biophysics and Molecular Biology
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] comparison of their actions in insulin and. cell preservation2011
- Author(s)
  Yabe D, Seino Y.
- Journal Title
  
  Progress in Biophysics and Molecular Biology
  
  Volume: 107 Issue: 2 Pages: 248-256
- DOI
  10.1016/j.pbiomolbio.2011.07.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] The effect of gastric inhibitory polypeptide on intestinal glucose absorption and intestinal motility in mice Biochemical Biophysical2011
- Author(s)
  Ogawa E, Yamane S, Toyoda K, Seino Y, Inagaki N, et al.
- Journal Title
  
  Research Communication
  
  Volume: 404 Issue: 1 Pages: 115-120
- DOI
  10.1016/j.bbrc.2010.11.077
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] Two incretin hormones GLP-1 and GIP : Comparison of their actions in insulin secretion andβcell preservation2011
- Author(s)
  Yabe D, Seino Y.
- Journal Title
  
  Progress in Biophysics and Molecular Biology
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] Beneficial effects of exendin-4 on experimental polyneuropathy in diabetic mice2011
- Author(s)
  Himeno T, Seino Y, et al.
- Journal Title
  
  Diabetes
  
  Volume: 60 Issue: 9 Pages: 2397-2406
- DOI
  10.2337/db10-1462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132, KAKENHI-PROJECT-21592506, KAKENHI-PROJECT-22590975, KAKENHI-PROJECT-22592322
[Journal Article] Little enhancement of meal-induced glucagon-like peptide 1 secretion in Japanese : Comparison of type 2 diabetes patients and healthy controls2010
- Author(s)
  Yabe D, Kuroe A, Lee S, Watanabe K, Inagaki N, Seino Y, etal.
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 1 Pages: 56-59
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] Improved glycaemic control with minimal hypoglycaemia and no weight change with the once-daily human glucagon-like peptide-1 analogue liraglutide as add-on to sulphonylurea in Japanese patients with type 2 diabetes.2010
- Author(s)
  Kaku K, Rasmussen MF, Clauson P, Seino Y.
- Journal Title
  
  Diabetes, Obesity and Metabolism
  
  Volume: 12 Pages: 341-347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] Exendin-4 Protects Pancreatic Beta Cells from the Cytotoxic Effect of Rapamycin by Inhibiting JNK and p38 Phosphorylation2010
- Author(s)
  Kawasaki Y, Toyoda K, Yamane S, Seino Y, N. Inagaki et al.
- Journal Title
  
  Hormone and Metabolic Research
  
  Volume: 42 Issue: 05 Pages: 311-317
- DOI
  10.1055/s-0030-1249035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132, KAKENHI-PROJECT-22590975
[Journal Article] Improved glycaemic control with minimal hypoglycaemia and no weight change with the once-daily human glucagon-like peptide-1 analogue liraglutide as add-on to sulphonylurea in Japanese patients with type 2 diabetes.2010
- Author(s)
  Kaku K, Rasmussen MF, Clauson P, Seino Y.
- Journal Title
  
  Diabetes Obes Metab 12(4)
  
  Pages: 341-347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] Efficacy and safety of the once-daily human GLP-1 analogue, liraglutide, vsglibenclamide monotherapy in Japanese patients with type 2 diabetes.2010
- Author(s)
  Seino Y, Rasmussen MF, Nishida T, Kaku K.
- Journal Title
  
  Curr Med Res Opin 26(5)
  
  Pages: 1013-1022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] GIP and GLP-1, the two incretin hormones : Similarities and differences2010
- Author(s)
  Seino Y, Fukushima M, Yabe D.
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 1 Pages: 8-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] A GIP receptor agonist exhibits beta-cell anti-apoptotic actions in rat models of diabetes resulting in improved beta-cell function and glycemic control.2010
- Author(s)
  Widenmaier SB, Kim SJ, Yang GK, De Los Reyes T, Nian C, Asadi A, Seino Y, Kieffer TJ, Kwok YN, McIntosh CH
- Journal Title
  
  PLoS One 5(3)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] GPR119 regulates murine glucose homeostasis through incretin receptor-dependent and independent mechanisms2010
- Author(s)
  Flock G, Holland D, Seino Y, Drucker DJ.
- Journal Title
  
  Endocrinology
  
  Volume: 152 Pages: 374-383
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] Efficacy and safety of the once-daily human GLP-1 analogue, liraglutide, vsglibenclamide monotherapy in Japanese patients with type 2 diabetes.2010
- Author(s)
  Seino Y, Rasmussen MF, Nishida T, Kaku K.
- Journal Title
  
  Current Medical Research and Opinion
  
  Volume: 26 Pages: 1013-1022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] Differential importance of glucose-dependent insulinotropic polypeptide vs glucagon-like peptide 1 receptor signaling for beta cell survival in mice Gastroenterology2009
- Author(s)
  Maida A, Seino Y, et al.
- Journal Title
  
  Gastroenterology
  
  Volume: 137 Issue: 6 Pages: 2146-2157
- DOI
  10.1053/j.gastro.2009.09.004
- ISSN
  0016-5085
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132
[Presentation] The effects of glucose and meal ingestion on incretin secretion in Japanese subjects with normal glucose tolerance2011
- Author(s)
  山根俊介、清野裕, et al
- Organizer
  47^<th> annual meeting of the European Association for the Study of Diabetes
- Place of Presentation
  Lisbon, Portugal
- Year and Date
  2011-09-14
- Data Source
  KAKENHI-PROJECT-21591132
[Presentation] Clinical Implication of Incretin Treatment in Asian type 2 Diabetes2011
- Author(s)
  清野裕
- Organizer
  3rd AASD Plenary Lecture
- Place of Presentation
  北京、中国
- Data Source
  KAKENHI-PROJECT-21591132
[Presentation] The effects of glucose and meal ingestion on incretin secretion in Japanese subjects with normal glucose tolerance2011
- Author(s)
  山根俊介、原田範雄、豊田健太郎、清野裕、稲垣暢也
- Organizer
  47th annual meeting of the European Association for the Study of Diabetes
- Place of Presentation
  リスボン、ポルトガル
- Year and Date
  2011-09-14
- Data Source
  KAKENHI-PROJECT-21591132
[Presentation] 糖尿病専門診療のあり方2011
- Author(s)
  清野裕
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-21591132
[Presentation] Incretin-Based Drugs ; Potential and Problems in Asian Countries4th Asian Islet Biology and Incretin Study Group(AIBIS) Symposium2011
- Author(s)
  矢部大介、清野裕
- Organizer
  4th Asian Islet Biology and Incretin Study Group(AIBIS) Symposium
- Place of Presentation
  北京、中国
- Data Source
  KAKENHI-PROJECT-21591132
[Presentation] Clinical Implication of Incretin Treatment in Asian type 2 Diabetes2011
- Author(s)
  清野裕
- Organizer
  3rd AASD Plenary Lecture
- Place of Presentation
  北京(中国)
- Data Source
  KAKENHI-PROJECT-21591132
[Presentation] 日本人2型糖尿病患者にインクレチン関連薬の有用性-日本人のインクレチン分泌と実臨床での効果を踏まえて2011
- Author(s)
  矢部大介、清野裕
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-21591132
[Presentation] 糖尿病専門診療のあり方2011
- Author(s)
  清野裕
- Organizer
  日本糖尿病学会年次学術集会Symposium 16
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21591132
[Presentation] GLP-1アナログによるAkitaマウスの小胞体ストレス減少効果2009
- Author(s)
  山根俊介、浜本芳之、原田範雄、豊田健太郎、清野裕、稲垣暢也
- Organizer
  第5回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-05-21
- Data Source
  KAKENHI-PROJECT-21591132
[Presentation] LP-1アナログによるAkitaマウスの小胞体ストレス減少効果2009
- Author(s)
  山根俊介、原田範雄、山田千積、豊田健太郎、浜本芳之、清野裕、稲垣暢也
- Organizer
  第5回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-05-21
- Data Source
  KAKENHI-PROJECT-21591132
[Presentation] GLP-1 receptor activation attenuates beta cell damage in Akita mice2008
- Author(s)
  山根俊介、浜本芳之、原田範雄、豊田健太郎、清野裕、稲垣暢也
- Organizer
  第44回欧州糖尿病学会
- Place of Presentation
  ローマ、イタリア
- Year and Date
  2008-09-09
- Data Source
  KAKENHI-PROJECT-19591046
[Presentation] GLP-1シグナルの増強はAkitaマウスの膵β細胞障害を抑制する2008
- Author(s)
  山根俊介、原田範雄、山田千積、豊田健太郎、浜本芳之、清野裕、稲垣暢也
- Organizer
  第51回日本糖尿病学会年次学術集会
- Year and Date
  2008-05-23
- Data Source
  KAKENHI-PROJECT-19591046

1. ISHIDA Hitoshi (80212893)

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2. IMURA Hiroo (10025570)

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seino yutaka 清野 裕

清野 裕 セイノ ユタカ

SEINO Yutaka 清野 裕

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Investigation for intracellular mechanisms of pancreatic-cell proliferation and anti-apoptotic effect of incretinPrincipal Investigator

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Effect of incretin on beta cell proliferation and prevention of diabetesPrincipal Investigator

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Gut-peptides regulate metabolism in whole body.Principal Investigator

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Analysis of transcriptional network in pancreatic β-cellsPrincipal Investigator

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ソマトスタチンによる腫瘍増殖抑制機構の解析Principal Investigator

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Characterizetion of glucose-induced signal transduction and its impairment in type 2 diabetePrincipal Investigator

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ソマトスタチンによる抗腫瘍効果の分子機構に関する研究Principal Investigator

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Development of new hypoglycemic agents with a novel insulinotropic mechanism and their clinical appkicatiorPrincipal Investigator

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seino yutaka 清野裕

清野裕セイノユタカ

SEINO Yutaka 清野裕