KOYAMA Hideki 小山秀機

… Alternative Names

小山秀機コヤマヒデキ

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Researcher Number	40085626
Other IDs
Affiliation (based on the past Project Information) *help	2007: Yokohama City University, 国際総合科学研究科, 名誉教授 2007: Yokohama City University, International Graduate School of Arts and Sciences, Professor 1998 – 2006: 横浜市立大学, 木原生物学研究所, 教授 2005: Yokohama City University, Kihara Institute for Biological Research, Professor, 教授 1995: 横浜市立大学, 木原生研, 教授 1994: 横浜市立大学, 木原生物学研究所, 教授 1990: 横浜市立大学, 木原生物学研究所, 教授
Review Section/Research Field	Principal Investigator Biological Sciences / Molecular biology / Molecular biology / Cell biology Except Principal Investigator Basic veterinary science/Basic zootechnical science / Biological Sciences / Basic veterinary science/Basic zootechnical science / Applied molecular and cellular biology
Keywords	Principal Investigator ジーンターゲティング / ヒト細胞 / FEN1 / 塩基除去修復 / DNAポリメラーゼβ / がん / KU70 / 突然変異 / DNAリガーゼIV / BLM … More / 非相同的末端連結 / ブルーム症候群 / repair / genome / cancer / gene / genetics / ゲノム不安定性 / 遺伝子相互作用 / 組換え修復 / 遺伝子破壊株 / 修復 / ゲノム / 遺伝子 / 遺伝学 / Long-patch BER / Short-patch BER / knockout cell / Gene targeting / chicken DT40 cell / DNA polymerase beta / Base excision repair / BER活性 / 相同組換え / 非相同組換え / シーンターゲティング / 塩基除去修復活性 / 薬剤感受性 / 組換え能 / ニワトリDT40細胞 / TEN1 / Mutation / Checkpoint / Apoptosis / Abnormal neurogenesis / Knockout mouse / DNA repair / DNA polymerase? / チェックポイント / 細胞死 / 神経発生異常 / ノックアウトマウス / DNA修復 / 条件致死変異株 / 有糸分裂組換え / APRT遺伝子 / ノックアウト細胞 / Ku70 / 癌 / ジーンターゲテイング / ベクター / トポイソメラーゼ / 組換え / 動物細胞 … More Except Principal Investigator reactive oxygen species / neutrophil / 活性酸素 / 好中球 / infectious disease / immunology / myeloperoxidase / 感染 / 感染症 / 免疫 / ミエロペルオキシダーゼ / トポイソメラーゼ / Nalm-6 / DNA鎖切断 / apoptosis / inflammation / infection / アポトーシス / 炎症 / nonhomologous recombination / bleomycin / topoisomerase / gene transfer / mammalian cell / DNA / 非相同的組換え / ブレオマイシン / 遺伝子導入 / 動物細胞 / 逆遺伝的解析 / 逆遺伝学的解析 / DNA損傷応答 / TDP1 / ノックアウト / ヒト遺伝子 / ジーンターゲッティング / 前立腺癌 / 膀胱癌 / DNA-polymerase β / シグナル伝達系 / cGMP_-依存プロテインキナーゼ / D群不死化細胞株 / 微小核細胞融合法 / 7番目染色体 / 細胞老化遺伝子 / リン酸化 / ヒストンH1キナ-ゼ / トポイソメラ-ゼ / ユビキチン活性化酵素 / チミジル酸ストレス / 染色体異常 / 温度感受性変異株 / 細胞周期 Less

ヒトDNA鎖切断修復の逆遺伝学的解析と医療への応用
- Principal Investigator
  
  足立典隆
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
ヒト染色体DNA切断とその修復機構
- Principal Investigator
  
  足立典隆
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
Genetic studies on the interaction between base excision repair and recombinational repair using human gene knockout cellsPrincipal Investigator
- Principal Investigator
  
  KOYAMA Hideki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Yokohama City University
ヒト遺伝子の系統的な機能解析に向けた高効率ジーンターゲティング系の開発Principal Investigator
- Principal Investigator
  
  小山秀機
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
ヒトプレB細胞よりBLM破壊株の作製とその非相同組換え能の解析Principal Investigator
- Principal Investigator
  
  小山秀機
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
Impaired host defense and increased inflammation in mice deficient in myeloperoxidase and NADPH-oxidase
- Principal Investigator
  
  ARATANI Yasuaki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Yokohama City University
ヒトプレB細胞よりBLM破壊株の作製とそ非相同的末端連結能の解析Principal Investigator
- Principal Investigator
  
  小山秀機
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
Studies of base excision repair in cell mutants deficient. in either DNA polymerase, or flap endonuclease-1 or both, generated from chicken DT40 cells.Principal Investigator
- Principal Investigator
  
  KOYAMA Hideki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Yokohama City University, Kihara Institute for Biological Research
Impaired host defense in mice deficient in myeloperoxidase
- Principal Investigator
  
  ARATANI Yasuaki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Yokohama City University
Analysis of functions of DNA polymerase? with knockout mice.Principal Investigator
- Principal Investigator
  
  KOYAMA Hideki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Yokohama City University
Host Defense and Inflammatory Diseases in Mice Deficient in Myeloperoxidase
- Principal Investigator
  
  ARATANI Yasuaki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Yokohama City University
Stimulation of gene transfer efficiency by treatment of human cells with topoisomerase II inhibitors
- Principal Investigator
  
  ARATANI Yasuaki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  Yokohama City University
DNA-polymerase βのヒトがんの発生・進展への関わりについての研究
- Principal Investigator
  
  窪田吉信
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Yokohama City University
がん細胞の不死化遺伝子の同定
- Principal Investigator
  
  鮎沢大
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
哺乳類細胞の組換えにおけるトポイソメラーゼの関与Principal Investigator
- Principal Investigator
  
  小山秀機
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Yokohama City University
がん細胞における染色体の不安定化と再配列に関与する分子遺伝学的研究
- Principal Investigator
  
  瀬野捍二
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  National Institute of Genetics

All 2006 2005 2004 2003

All Journal Article

[Journal Article] Contribution of the myeloperoxidase-dependent oxidative system to host defense against Cryptococcus neoformans.2006
- Author(s)
  Aratani, Y., Kura, F., Watanabe, H., Akagawa, H., Takano, Y., Ishida-Okawara, A., Suzuki, K., Maeda, N., Koyama, H
- Journal Title
  
  J.Med.Microbiol. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16580243
[Journal Article] Earlier onset of neutrophil-mediated inflammation in the ultraviolet-exposed skin of mice deficient in myeloperoxidase and NADPH oxidase.2006
- Author(s)
  Komatsu, J., Koyama, H., Maeda, N., Aratani, Y
- Journal Title
  
  Inflamm.Res. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16580243
[Journal Article] Phorbol myristate acetate induces neutrophil death through activation of p38 mitogen-activated protein kinase that requires endogenous reactive oxygen species other than HOCl.2005
- Author(s)
  Saito, T., Takahashi, H., Doken, H., Koyama, H., Aratani, Y
- Journal Title
  
  Biosci.Biotech.Biochem. 69
  
  Pages: 2207-2212
- NAID
  130000030496
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16580243
[Journal Article] Genetic interaction between DNA polymerase b and DNA-PKcs in neurogenesis and embryogenesis2005
- Author(s)
  Niimi, N., Sugo, N., Aratani, Y., Koyama, H.
- Journal Title
  
  Cell Death Differentiation 12
  
  Pages: 184-191
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570146
[Journal Article] Genetic interaction between DNA polymerase beta and DNA-PKcs in embryogenesis and neurogenesis.2005
- Author(s)
  Niimi, N., Sugo, N., Aratani, Y., Koyama, H
- Journal Title
  
  Cell Death Differ 12
  
  Pages: 184-191
- Data Source
  KAKENHI-PROJECT-16580243
[Journal Article] Edivence for a role of vertebrate Rad52 in the repaire of topoisomerase II-mediated DNA damage2005
- Author(s)
  Adachi, N., Iiizumi, S., Koyama, H.
- Journal Title
  
  DNA Cell Biol. 24
  
  Pages: 388-393
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570146
[Journal Article] Genetic evidence for involvement of two distinct nonhomologous end-joining pathways in repair of topoisomerase II-mediated DNA damage2004
- Author(s)
  Adachi, N., Iiizumi, S., So, S., Koyama, H.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 318
  
  Pages: 856-861
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570146
[Journal Article] In vivo role of myeloperoxidase for the host defense.2004
- Author(s)
  Aratani, Y., Kura, F., Watanabe, H., Akagawa, H., Takano, Y., Suzuki, K., Dinauer, M.C., Maeda, N., Koyama, H
- Journal Title
  
  Jpn.J.Infect.Dis. 57
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16580243
[Journal Article] p53 deficiency rescues neuronal apoptosis but not differentiation in DNA polymerase b-deficient mice.2004
- Author(s)
  Sugo, N., Niimi, N., Aratani, Y., Takiguchi-Hahashi, K., Koyama, H
- Journal Title
  
  Mol.Cell Biol 24
  
  Pages: 9470-9477
- Data Source
  KAKENHI-PROJECT-16580243
[Journal Article] Genetic interactions between BLM and the nonhomologous end-joining pathway in human cells2004
- Author(s)
  So, S., Adachi, N., Lieber, M., Koyama, H.
- Journal Title
  
  J. Biol. Chem. 279
  
  Pages: 55433-55442
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570146
[Journal Article] p53 deficiency rescues apoptosis but not differentiation in DNA polymerase beta-deficient mice2004
- Author(s)
  Sugo, N., Niimi, N., Aratani, Y., Hayashi, K., Koyama, H.
- Journal Title
  
  Mol. Cell. Biol. 24
  
  Pages: 9470-9477
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570146
[Journal Article] Loss of nonhomologous end-joining confers camptothecin resistance in DT40 cells: Implications for the repair of topoisomerase I-mediated DNA damage2004
- Author(s)
  Adachi, N., So, S., Koyama, H.
- Journal Title
  
  J. Biol. Chem. 279
  
  Pages: 37343-37348
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570146
[Journal Article] Hypersensitivity of nonhomologous DNA end-joining mutants to VP-16 and ICRF-193-Imprications for repair of topoisomerase II-mediated DNA damage2003
- Author(s)
  Adachi, N., Suzuki, H., Iizumi, S., Koyama, H.
- Journal Title
  
  J. Biol. Chem. 278
  
  Pages: 35897-35902
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570146
[Journal Article] Decreased c-myc expression involved in X-ray-induced apoptotic cell death of human T-cell leukemia cell line MOLT-42003
- Author(s)
  Enomoto, A., Suzuki, N., Kang, Y., Hirano, K., Matsumoto, Y., Zhu, J., Morita, A., Hosoi, Y., Sakai, K., Koyama, H.
- Journal Title
  
  Int. J. Radiat. Biol. 79
  
  Pages: 589-600
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570146
[Journal Article] Enforced cytokinesis without complete nuclear division in embryonic cells depleting the activity of DNA topoisomerase II α2003
- Author(s)
  Akimitsu, N., Adachi, N., Hirai, H., Hossain, M.S., Hamamoto, H., Kobayashi, M., Aratani, Y.Koyama, H., Sekimizu, K.
- Journal Title
  
  Gene Cells 8
  
  Pages: 393-402
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570146

1. ADACHI Noritaka (30264675)

# of Collaborated Projects: 7 results

# of Collaborated Products: 6 results
2. ARATANI Yasuaki (30192470)

# of Collaborated Projects: 6 results

# of Collaborated Products: 6 results
3. 鮎沢大 (00142109)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. KURA Fumiaki (30161722)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SUZUKI Kazuo (20192130)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 瀬野捍二 (30076989)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 安藤俊夫 (20012693)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 綿矢有佑 (90127598)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 辻秀雄 (40163795)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 大石道夫 (00126004)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 窪田吉信 (10106312)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 執印太郎 (80179019)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KOYAMA Hideki 小山 秀機

小山 秀機 コヤマ ヒデキ

Research Projects

Research Products

Co-Researchers

Principal Investigator

Project Period (FY)

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Review Section

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Genetic studies on the interaction between base excision repair and recombinational repair using human gene knockout cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒト遺伝子の系統的な機能解析に向けた高効率ジーンターゲティング系の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ヒトプレB細胞よりBLM破壊株の作製とその非相同組換え能の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒトプレB細胞よりBLM破壊株の作製とそ非相同的末端連結能の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies of base excision repair in cell mutants deficient. in either DNA polymerase, or flap endonuclease-1 or both, generated from chicken DT40 cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of functions of DNA polymerase? with knockout mice.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Institution

哺乳類細胞の組換えにおけるトポイソメラーゼの関与Principal Investigator

KOYAMA Hideki 小山秀機

小山秀機コヤマヒデキ