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NISHINO TAKESHI  西野 武士

… Alternative Names

Nishino Takeshi  西野 武士

NISHINO Takeshi  西野 武士

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Researcher Number 40094312
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-9065-8564
External Links
Affiliation (Current) 2025: 東京医療学院大学, 保健医療学部, 客員教授
Affiliation (based on the past Project Information) *help 2016 – 2017: 東京医療学院大学, 保健医療学部, 客員教授
2015: 東京大学, 大学院農学生命科学研究科(農学部), 特任教授
2012: 東京大学, 大学院・農学生命科学研究科, 特任教授
2012: 東京大学, 農学生命科学研究科, 教授
2007 – 2008: Nippon Medical School, Graduate School of Medicine, Professor … More
2006: 日本医科大学, 大学院医学研究科, 教授
2003 – 2005: NIPPON MEDICAL SCHOOL, Dept. Biochemistry and Molecular Biology, professor, 大学院・医学研究科, 教授
1994 – 2002: 日本医科大学, 医学部, 教授
1995 – 2000: 日本医科大学, 教授
1999: NIPPON MEDICAL SCHOOL, BIOCHEMISTRY AND MOLECULAR BIOLOGY, Professor, 大学院・医学研究科, 教授
1993: 日本医科大学, 医学部, 助教授
1990 – 1992: 横浜市立大学, 医学部, 助教授
1988: Yokohama city university, School of medicine, associate professor, 医学生化学, 助教授
1988: 横浜市立大学, 医学部, 助教授
1987: 横浜市立大学, 医学部, 講師 Less
Review Section/Research Field
Principal Investigator
Functional biochemistry / Pathological medical chemistry / Biological Sciences / Chemistry related to living body / Structural biochemistry / Neuroscience in general / Pathological medical chemistry
Except Principal Investigator
Pathological medical chemistry / 林産学 / Functional biochemistry … More / Pathological medical chemistry / Biological Sciences / Physical chemistry / Biophysics / 代謝生物化学 Less
Keywords
Principal Investigator
キサンチン酸化酵素 / キサンチン脱水素酵素 / 活性酸素 / 非ヘム鉄 / 金属フラビン酵素 / X線結晶解析 / 金属タンパク質 / ALS / ペルオキシレドキシン / 鉄結合タンパク質 … More / NO合成酵素 / モリブデン / non-heme iron / xanthine dehydrogenase / Xanthine Dehydrogenase / Xanthine Oxidase / EPR / フリーラジカル / 抗痛風薬 / キサンチン酸化還元酵素 / 筋萎縮性側索硬化症 / flavoprotein / nNOS / X-線結晶解析 / X線結晶構造 / 電子スピン共鳴 / パルスラジオリシス / 分子内電子伝達 / cDNA発現系 / 抗高尿酸血症治療薬 / タンパク質凝集 / 高尿酸血症治療薬 / プリンサルベージ回路 / 阻害剤による治療薬 / XOR酵素阻害剤 / COVID-19 / XOR阻害剤 / アルツハイマー病 / 神経変性疾患 / x-ray crystallography / Molecular dynamics / Xanthine oxidase / Anti-gout drug / Three-dimensional-structure based drug design / キサンチン脱水素酸素 / モリブデン配位子 / X-線結晶構造 / モリブデン水酸化機構 / モリブデン金属 / 蛋白質の基準振動計算 / X線結晶構造解析 / 蛋白質の基準振動検査 / キサンチンオキシダーゼ / 蛋白質の立体構造に基づく創薬 / Iron-binding protein / Peroxiredoxin / Non-heme iron / X-ray crystallography / Metallo protein / Active Oxygen / superoxide anion / active oxygen / molybdenum enzyme / xnathine oxidase / X-ray crystal structure / 部位特異的変異法 / スーパーオキシド / モリブデン酵素 / フラビン酵素 / heme binding protein / peroxiredoxin / metallo-protein / niric oxide synthase / xanthine oxidase / reactive oxygen species / super oxide anion / nitric oxide / free radical / metalloprotein / Flavoprotein / セロビオース脱水素酵素 / プリン代謝 / 抗痛風剤 / ペルオキレドキシン / スーパーオキサイドセンサー / 情報スウィチ蛋白質 / 金属リセプター / スーパーオキシサイドセンサー / NOセンサー / O_2センサー / COセンサー / 情報スイッチ蛋白質 / 情報伝達金属タンパク質 / 余属リセプター / 金属タンパク / heme / Ca / sinal transduction / hitric oxide / SoxR / チトクロムP450nor / チトクロムP450cam / ヘムオキシゲナーゼ / Sox R / チトクロム P450 nor / チトクロムP450 cam / ADP-リボシル化 / ハムオキシゲナーゼ / グアニル酸シクラーゼ / P450 / ヘム結合性ストレス蛋白 / SOXR / 鉄イオウタンパク質 / グアニル酸シクララーゼ / NO合成酵素(NOS) / HBP23 / peroxidase / 部位特異的変異 / 再灌流障害 / スーパーオキシドアニオン / cDNA発現 / バキュロビールス / パルスラジオロシス / バキロビ-ルス / 一次構造 / cDNAクロ-ニング / 複合金属酵素 / 複合フラビン酵素 / モリブドプテリン / バキロウィ-ルスベクタ- / 発現酵素 / 高次構造 / 複合金属フラビン酵素 … More
Except Principal Investigator
キサンチン酸化酵素 / キサンチン脱水素酵素 / 活性酸素 / Humicola insolens / flavoprotein / xanthine dehydrogenase / xanthine oxidase / フラビン酵素 / 金属タンパク質 / 生体情報変換 / 生体エネルギー変換 / グアニレートシクラーゼ / NO合成酵素 / Structure and function of the enzyme / cDNA cloning / Xanthine dehydrogenase / Purine nuceotide / プリンヌクレオチド分解 / CDNAクローニング / 反応速度論的解析 / 酵素の構造と機能 / cDNAクローニング / プリンヌクレオチド / Phanerochaefe chrysosporium / Oxidoreductase / Heme / Flavin / Biodegradation / Cellobiose dehydrogenase / Cellulose / Phanerochaete chrysosporium / 酸化還元酵素 / ヘム / フラビン / 生分解 / セロビオース脱水素酵素 / セルロース / oxygen activation / cytochrome oxidase / cytochromes / heme proteins / gene control / biometals / Metallo-nuclic acid / Metallo-proteins / 生体無機化学 / 小分子活性化 / 生体情報伝達 / 生体エネルギー / 生体金属 / 分子認識 / 人工変異タンパク質 / 金属核酸 / 分子生物学 / 構造生物学 / 生体分子科学 / 金属酵素 / 光合成 / 小分子の活性化 / 金属核酸錯体 / 金属タンパク / 生物無機化学 / superoxide dismutase / 分子内伝達 / パルスラジオリシス / CDNA発見 / 変異型酵素 / cDNA発現 / スーパーオキシドデイスムターゼ / スーパーオキシドデスムターゼ / 金属フラビン酵素 / Super oxide demstase / モリブデン酸素 / 酸化酵素型-脱水素酵素型変換 / ノックインマウス / モリブデン酵素 / キサンチチン脱水素酵素 / キサンチチン酸化酵素 / トランスジェニックマウス / キサンチン酸化還元酵素 / スーパーオキシド / 分子病態学 / 結晶構造 / 遺伝子発現制御 / ペルオキシターゼ / チトクロム酸化酵素 / 一酸化窒素 / チトクロムP-450 / NO-ヘム / ケージ化合物 / 緩和時間測定 / NMR分光法 / 蛋白質の動的構造 / 蛋白質の構造 / 時間分割解析 / ラウエ法 / X線結晶構造解析 / ス-パ-オキシドアニオン / チトクロムPー450 / オキシゲナ-ゼ / チトクロムcオキシダ-ゼ / 酸素毒性 / 酸素の活性化 / 酸素 Less
  • Research Projects

    (25 results)
  • Research Products

    (106 results)
  • Co-Researchers

    (50 People)
  •  Mechanism of effectof XOR inhibitors on delay of progress of neurodegenerative diseasesPrincipal Investigator

    • Principal Investigator
      Nishino Takeshi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      University of Tokyo Health Sciences
      The University of Tokyo
  •  Effects of Change in Purine Metabolism on Accumulation of Aggregated Proteins in the CellPrincipal Investigator

    • Principal Investigator
      NISHINO Takeshi
    • Project Period (FY)
      2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Pathological medical chemistry
    • Research Institution
      The University of Tokyo
  •  Phasogenesis study of XOR mutant knock-in mouse.

    • Principal Investigator
      OKAMOTO Ken, 西野 朋子
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Nippon Medical School
  •  Determination of fine structure of the molybdo-enzyme and mechanism of hydroxylation and protein vibration.Principal Investigator

    • Principal Investigator
      NISHINO Takeshi
    • Project Period (FY)
      2004 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Chemistry related to living body
    • Research Institution
      Nippon Medical School
  •  Structure and function complex flavo-proteins which produce free radicalsPrincipal Investigator

    • Principal Investigator
      NISHINO Takeshi
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      NIPPON MEDICAL SCHOOL
  •  複反応中心をもつ金属フラビソ蛋白群の構造と機能

    • Principal Investigator
      NISHINO Tomoko
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Nippon Medical School
      Yokohama City University
  •  金属が関与するセンサーとスイッチのケミカルバイオロジーPrincipal Investigator

    • Principal Investigator
      西野 武士
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Nippon Medical School
  •  活性酸素種による遺伝子発現誘導の分子基盤Principal Investigator

    • Principal Investigator
      西野 武士
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Nippon Medical School
  •  Investigation on Function and Molecular Structure of Cellobiose Dehydrogenase

    • Principal Investigator
      SAMEJIMA Masahiro
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      林産学
    • Research Institution
      The University of Tokyo
  •  The structure and function of a complex metalloflavoproteinPrincipal Investigator

    • Principal Investigator
      NISHINO Takeshi
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Structural biochemistry
    • Research Institution
      Nippon Medical School
  •  小脳におけるパルス状一酸化窒素発生の分子機構Principal Investigator

    • Principal Investigator
      西野 武士
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Neuroscience in general
    • Research Institution
      Nippon Medical School
  •  Structures and functions of metalloflavoenzymes which produce free radicalsPrincipal Investigator

    • Principal Investigator
      NISHINO Takeshi
    • Project Period (FY)
      1997 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Functional biochemistry
    • Research Institution
      NIPPON MEDICAL SCHOOL
  •  金属蛋白質による情報変換Principal Investigator

    • Principal Investigator
      西野 武士
    • Project Period (FY)
      1996 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Nippon Medical School
  •  Molecular Science on the Specific Roles of Metal Ions in Biological Functions.

    • Principal Investigator
      KITAGAWA Teizo
    • Project Period (FY)
      1996 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Okazaki National Research Institutes
  •  生体機能における金属イオンの特異的作用の分子科学

    • Principal Investigator
      北川 禎三
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      Physical chemistry
    • Research Institution
      Okazaki National Research Institutes
  •  生体系におけるNOの合成と反応及びその検出

    • Principal Investigator
      北川 禎三
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      Biophysics
    • Research Institution
      Okazaki National Research Institutes
  •  キサンチン酸化酵素のモリブデン配位子の構造と機能Principal Investigator

    • Principal Investigator
      西野 武士
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Nippon Medical School
  •  時間分割ラウエ法利用研究

    • Principal Investigator
      三井 幸雄
    • Project Period (FY)
      1993 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Nagaoka University of Technology
  •  キサンチン酸化酵素における活性酸素生成の分子機構とその病態における役割Principal Investigator

    • Principal Investigator
      西野 武士
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Nippon Medical School
  •  Electron transport system on complex flavoprotein

    • Principal Investigator
      ABE Yasuko
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Functional biochemistry
    • Research Institution
      Department of Biochemistry and Molecular Biology
  •  キサンチン酸化酵素のモリブデン配位子の構造と機能Principal Investigator

    • Principal Investigator
      西野 武士
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Yokohama City University
  •  生体系における酸素活性化とその制御の分子機構

    • Principal Investigator
      石村 巽
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      代謝生物化学
    • Research Institution
      Keio University
  •  キサンチン酸化酵素のモリブデン配位子の構造と機能Principal Investigator

    • Principal Investigator
      西野 武士
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Yokohama City University
  •  複合フラビン酵素の高次構造Principal Investigator

    • Principal Investigator
      西野 武士
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Yokohama City University
  •  Stracture and expression of genes of the enzymes involved in purine nucleotide catabolism

    • Principal Investigator
      TSUSHIMA Keizo
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Yokohama city university, School of medicine

All 2018 2017 2016 2015 2013 2012 2011 2010 2009 2008 2007 2006 2005 2002 2000 1999 Other

All Journal Article Presentation Book Patent

  • [Book] Metallobiology2017

    • Author(s)
      T. Nishino, K. Okamoto and S. Leimkuehler
    • Total Pages
      47
    • Publisher
      Royal Society Press, London
    • Data Source
      KAKENHI-PROJECT-15H04702
  • [Book] New-Generation Uric Acid Production InhibitoFebuxostat, in Analogue-based Drug DiccoverIII (eds. J. Fischer, C. R. Canellin and D. Rotella )2013

    • Author(s)
      Okamoto, K., Kondo, S. and Nishino, T
    • Publisher
      Wiley-VCH
    • Data Source
      KAKENHI-PROJECT-24659144
  • [Book] HANDBOOK OF METALLOPROTEINS2008

    • Author(s)
      Takeshi Nishino, Emil F.Pai
    • Total Pages
      14
    • Publisher
      Wiley
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Book] METALIONS IN BIOLOGOCAL SISTEMS : Molybdenum and Tungsten : Their Roles in Biological Processes (The Molybdenum-Containing Xanthine Oxidoreductases and Picolinate Dehydrogenases.)2002

    • Author(s)
      E.F.Pai, T.Nishino
    • Total Pages
      24
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-10044324
  • [Book] Flavins and Flavoproteins : The mechanism of Conversion from Xanthine Dehydrogenase to Oxidase of Rat Enzyme Studied by Site-Directed Mutagenesis. (S.Ghisla et al., eds.)1999

    • Author(s)
      T.Nishino, K.Okamoto, H.Hori, A.Kounosu, T.Nishino
    • Total Pages
      4
    • Publisher
      RUDOLF WEBER AGENCY FOR SCIENTIFIC PUBLICATIONS
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-10044324
  • [Book] Flavins and Flavoproteins : Crystal structure of xanthine oxidreductase and EPR assignment of Fe/S center. (S.Ghisla et al., eds.)1999

    • Author(s)
      C.Enroth, B.T.Eger, E.F.Pai, K.Okamoto, T.Iwasaki, T.Nishino, T.Nishino
    • Total Pages
      4
    • Publisher
      RUDOLF WEBER AGENCY FOR SCIENTIFIC PUBLICATIONS
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-10044324
  • [Journal Article] Chemical Nature and Reaction Mechanisms of the Molybdenum Cofactor of Xanthine Oxidoreductase2013

    • Author(s)
      K. Okamoto, T. Kusano, T. Nishino.
    • Journal Title

      Curr. Pham. Des.

      Volume: 19 Issue: 14 Pages: 2606-2614

    • DOI

      10.2174/1381612811319140010

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23570198, KAKENHI-PROJECT-24590393, KAKENHI-PROJECT-24659144
  • [Journal Article] Mutations associated with functional disorder of xanthine oxidoreductase and hereditary xanthinuria in humans.2012

    • Author(s)
      Ichida K, Amaya Y, Okamoto K, Nishino T.
    • Journal Title

      Int J Mol Sci

      Volume: 13 Issue: 11 Pages: 15475-15495

    • DOI

      10.3390/ijms131115475

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590393, KAKENHI-PROJECT-24659144
  • [Journal Article] FYX-051 : a novel and potent hybrid-type inhibitor of xanthine oxidoreductase.2011

    • Author(s)
      Matsumoto K, Okamoto K, Ashizawa N, Nishino T.
    • Journal Title

      J Pharmacol Exp Ther.

      Volume: 336 Pages: 95-103

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590317
  • [Journal Article] FYX-051 : a novel and potent hybrid-type inhibitor of xanthine oxidoreductase.2011

    • Author(s)
      Matsumoto K, Okamoto K, Ashizawa N, Nishino T
    • Journal Title

      J Pharmacol Exp Ther. Jan ; 336(1)

      Pages: 95-103

    • Data Source
      KAKENHI-PROJECT-20590317
  • [Journal Article] Crystal Structures of Urate Bound Form of Xanthine Oxidoreductase : Substrate Orientation and Structure of the Key Reaction Intermediate.2010

    • Author(s)
      Okamoto K, Kawaguchi Y, Eger BT, Pai EF, Nishino T.
    • Journal Title

      J Am Chem Soc.

      Volume: 132 Pages: 17080-17083

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590317
  • [Journal Article] Crystal structures of mammalian xanthine oxidoreductase bound with various inhibitors : allopurinol, febuxostat, and FYX-0512008

    • Author(s)
      Okamoto K, Nishino T
    • Journal Title

      J Nippon Med Sch. Feb ; 75(1)

      Pages: 2-3

    • NAID

      130004057313

    • Data Source
      KAKENHI-PROJECT-20590317
  • [Journal Article] Mammalian xanthine oxidoreductase-mechanism of transition from xanthine dehydrogenase to xanthine oxidase.2008

    • Author(s)
      Nishino T
    • Journal Title

      FEBS J. 275

      Pages: 3278-3289

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590317
  • [Journal Article] Mammalian xanthine oxidoreductase-mechanism of transition from xanthine ehydrogenase to xanthine oxidase.2008

    • Author(s)
      Nishino T, Okamoto K, Eger BT, Pai EF, Nishino T
    • Journal Title

      FEBS J. Jul ; 275(13)

      Pages: 3278-89

    • Data Source
      KAKENHI-PROJECT-20590317
  • [Journal Article] Structure and mechanism of molybdenum hydroxylase2008

    • Author(s)
      Okamoto K, Nishino T.
    • Journal Title

      [Article in Japanese]Seikagaku. Jun ; 80(6)

      Pages: 531-9

    • NAID

      10021192278

    • Data Source
      KAKENHI-PROJECT-20590317
  • [Journal Article] Mammalian xanthine oxidoreductase-mechanism of transition from xanthine dehydrogenase to xanthine oxidase2008

    • Author(s)
      Tomoko Nishino
    • Journal Title

      FEBS.J 275

      Pages: 3278-3289

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Journal Article] Xanthine oxidoreductase2008

    • Author(s)
      Takeshi Nishino, Emil F.Pai
    • Journal Title

      HANDBOOK OF METALLOPROTEINS(Wiley)

      Pages: 1-14

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Journal Article] Mechanism of inhibition of xanthine oxidoreductase by allopurinol : crystal structure of reduced bovine milk xanthine oxidoreductase bound with oxipurinol.2008

    • Author(s)
      Okamoto K, Eger BT, Nishino T, Pai EF, Nishino T
    • Journal Title

      Nucleosides Nucleotides Nucleic Acids. Jun ; 27(6)

      Pages: 888-93

    • Data Source
      KAKENHI-PROJECT-20590317
  • [Journal Article] Mammalian xanthine oxidoreductase - mechanism of transition from xanthine dehydrogenase to xanthine oxidase2008

    • Author(s)
      Tomoko Nishino
    • Journal Title

      FEBS.J. 275

      Pages: 3278-3289

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Journal Article] Mechanism of the Conversion of Xanthine Dehydrogenase to Xanthine Oxidase2005

    • Author(s)
      Tomoko Nishino et al.
    • Journal Title

      J.Biol.Chem. 280・26

      Pages: 24888-24894

    • NAID

      10021987364

    • Data Source
      KAKENHI-PROJECT-16205021
  • [Journal Article] Mechanism of the Conversion of Xanthine Dehydrogenase to Xanthine Oxidase2005

    • Author(s)
      Tomoko Nishino, et al
    • Journal Title

      J.Biol.Chem. 280(26)

      Pages: 24888-24894

    • NAID

      10021987364

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Journal Article] Mecchanism of the Conversion of Xanthine Dehydrogenase to Xanthine Oxidase2005

    • Author(s)
      Tomoko Nishino, et al.
    • Journal Title

      J.Biol.Chem. 280・26

      Pages: 24888-24894

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Journal Article] METAL IONS IN BIOLOGOCAL SISTEMS : Molybdenum and Tungsten : Their Roles in Biological Processes2002

    • Author(s)
      E.F.Pai, T.Nishino
    • Journal Title

      The Molybdenum-Containing Xanthine Oxidoreductases and Picolinate Dehydrogenases

      Pages: 24-24

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-10044324
  • [Journal Article] Purification, crystallization and preliminary X-ray siffraction studies of xanthine dehydrogebse and xanthine oxidase isolated from bovine milk.2000

    • Author(s)
      B.T.Eger, K.Okamoto, C.Enroth, M.Sato, T.Nishino, E.F.Pai, T.Nishino
    • Journal Title

      Acta Cryst. D56

      Pages: 1656-1658

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-10044324
  • [Journal Article] The role of the [2Fe-2S] cluster centers in xanthine oxidoreductase.2000

    • Author(s)
      T.Nishino, K.Okamoto
    • Journal Title

      Journal of Inorganic Biochemistry 82

      Pages: 43-49

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-10044324
  • [Journal Article] Sequence Motif-Specific Assignment of Two [2Fe-2S] Clusters in Rat Xanthine Oxidoreductase Studied by Site-Directed Mutagenesis.2000

    • Author(s)
      T.Iwasaki, K.Okamoto, T.Nishino, J.Mizushima, H.Hori, T.Nishino
    • Journal Title

      J.Biochem. 127

      Pages: 771-778

    • NAID

      10005443636

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-10044324
  • [Journal Article] Sequence Motif-Specific Assignment of Two [2Fe-2S] Clusters in Rat Xanthine Oxidoreductase Studied by Site-Directed Mutagenesis2000

    • Author(s)
      T.Iwasaki, K.Okamoto, T.Nishino, J.Mizushima, H.Hori, T.Nishino
    • Journal Title

      J.Biochem. 127

      Pages: 771-778

    • NAID

      10005443636

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-10044324
  • [Journal Article] The role of the [2Fe-2S] cluster centers in xanthine oxidoreductase2000

    • Author(s)
      T.Nishino, K.Okamoto
    • Journal Title

      Journal of Inorganic Biochemistry 82

      Pages: 43-49

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-10044324
  • [Journal Article] Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase : Structure-based mechanism of conversion.2000

    • Author(s)
      C.Enroth, B.T.Eger, K.Okamoto, T.Nishino, T.Nishino, E.F.Pai
    • Journal Title

      Proc.Natle.Acad, Scie., USA 97

      Pages: 10723-10728

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-10044324
  • [Journal Article] Cellobiose Dehydrogenase from the Fungi Phanerochaete chrysosporium and Humicola insolens1999

    • Author(s)
      K.Igarashi, M.Verhagen, M.Samejima, M.Schulein, K.L.Eriksson, Takeshi Nishino
    • Journal Title

      J.Biol.Chem. 274

      Pages: 3338-3344

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-10044324
  • [Journal Article] Modulation of the Remote Heme Site Geometry of Recombinant Mouse Neuronal Nitric-oxide Synthase by the N-terminal Hook Region.1999

    • Author(s)
      T.Iwasaki, H.Hori, Y.Hayashi, T.Nishino
    • Journal Title

      J.Biol.Chem. 274

      Pages: 7705-7713

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-10044324
  • [Journal Article] Characterization of Mouse nNOS2, a Natural Variant of Neuronal Nitric-oxide Synthase Produced in the Central Nervous System by Selective Alternative Splicing.1999

    • Author(s)
      T.Iwasaki, H.Hori, Y.Hayashi, T.Nishino, K.Tamura, S.Oue, T.Iizuka, T.Ogura, H.Esumi
    • Journal Title

      J.Biol.Chem. 274

      Pages: 17559-7566

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-10044324
  • [Journal Article] Inhibition of Xanthine Oxidase and Xanthine Dehydrogenase by Nitric Oxide.1999

    • Author(s)
      K.Ichimori, M.Fukahori, H.Nakazawa, K.Okamoto, Takeshi Nishino
    • Journal Title

      J.Biol.Chem. 274

      Pages: 7763-7768

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-10044324
  • [Journal Article] Characterization of Mouse nNOS2, a Natural Variant of Neuronal Nitric-oxide Synthase Produced in the Central Nervous System by Selective Alternative Splicing1999

    • Author(s)
      T.Iwasaki, H.Hori, Y.Hayashi, T.Nishino, K.Tamura, S.Oue, T.Iizuka, T.Ogura, H.Esumi
    • Journal Title

      J.Biol.Chem. 274

      Pages: 17559-17566

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-10044324
  • [Journal Article] Cellobiose Dehydrogenase from the Fungi Phanerochaete chrysosporium and Humicola insolens.1999

    • Author(s)
      K.Igarashi, M.Verhagen, M.Samejima, M.Schulein, K.L.Eriksson, Takeshi Nishino
    • Journal Title

      J.Biol.Chem. 274

      Pages: 3338-3344

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-10044324
  • [Journal Article] Flavins and Flavoproteins (S.Ghisla et al., eds.) : Crystal structure of xanthine oxidreductase and EPR assignment of Fe/S center.1999

    • Author(s)
      C.Enroth, B.T.Eger, E.F.Pai, K.Okamoto, T.Iwasaki, T.Nishino, T.Nishino
    • Journal Title

      RUDOLF WEBER AGENCY FOR SCIENTIFIC PUBLICATIONS

      Pages: 4-4

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-10044324
  • [Journal Article] Flavins and Flavoproteins (S.Ghisla et al., eds.) : The mechanism of Conversion from Xanthine Dehydrogenase to Oxidase of Rat Enzyme Studied by Site-Directed Mutagenesis.1999

    • Author(s)
      T.Nishino, K.Okamoto, H.Hori, A.Kounosu, T.Nishino
    • Journal Title

      RUDOLF WEBER AGENCY FOR SCIENTIFIC PUBLICATIONS

      Pages: 4-4

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-10044324
  • [Journal Article] Modulation of the Remote Heme Site Geometry of Recombinant Mouse Neuronal Nitric-oxide Synthase by the N-terminal Hook Region1999

    • Author(s)
      T.Iwasaki, H.Hori, Y.Hayashi, T.Nishino
    • Journal Title

      J.Biol.Chem. 274

      Pages: 7705-7713

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-10044324
  • [Journal Article] Inhibition of Xanthine Oxidase and Xanthine Dehydrogenase by Nitric Oxide1999

    • Author(s)
      K.Ichimori, M.Fukahori, H.Nakazawa, K.Okamoto, Takeshi Nishino
    • Journal Title

      J.Biol.Chem. 274

      Pages: 7763-7768

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-10044324
  • [Journal Article] Crystal Structures of Urate Bound Form of Xanthine Oxidoreductase : Substrate Orientation and Structure of the Key Reaction Intermediate.

    • Author(s)
      Okamoto K, Kawaguchi Y, Eger BT, Pai EF, Nishino T
    • Journal Title

      J Am Chem Soc.

      Pages: 2010-2010

    • Data Source
      KAKENHI-PROJECT-20590317
  • [Patent] 認知症治療または予防薬2017

    • Inventor(s)
      西野武士、加藤信介、加藤雅子、鈴木秀典、岡本研
    • Industrial Property Rights Holder
      西野武士、加藤信介、加藤雅子、鈴木秀典、岡本研
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017-02-17
    • Overseas
    • Data Source
      KAKENHI-PROJECT-15H04702
  • [Patent] Therapeutic agent for amyotrophic lateral sclerosis2012

    • Inventor(s)
      Takeshi Nishino, Yasuko Abe Shinsuke Kato
    • Industrial Property Rights Holder
      Nippon Medical School Foundation and National University Corporation Tottori University
    • Acquisition Date
      2012-11-27
    • Overseas
    • Data Source
      KAKENHI-PROJECT-24659144
  • [Patent] 筋萎縮性側索硬化症治療薬2012

    • Inventor(s)
      西野武士, 阿部靖子、加藤信介
    • Industrial Property Rights Holder
      学校法人日本医科大学国立大学法人鳥取大学
    • Acquisition Date
      2012-10-19
    • Data Source
      KAKENHI-PROJECT-24659144
  • [Patent] 筋萎縮性側索硬化症治療薬2007

    • Inventor(s)
      西野武士, 阿部靖子, 加藤信介
    • Industrial Property Rights Holder
      日本医科大学・鳥取大学
    • Filing Date
      2007-07-13
    • Description
      「研究成果報告書概要(和文)」より
    • Overseas
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Presentation] エネルギー代謝から見た XOR(XDH/XO)の臓器間局在性とプリンサルベージ回路の 重要性についての仮説2018

    • Author(s)
      西野 武士、細山田 真、鎌谷 直之
    • Organizer
      日本痛風核酸代謝学会
    • Data Source
      KAKENHI-PROJECT-15H04702
  • [Presentation] ヒトが高尿酸血症を呈するようになった理由の新たな説明2018

    • Author(s)
      鎌谷 直之、細山田 真、西野 武士
    • Organizer
      日本痛風核酸代謝学会
    • Data Source
      KAKENHI-PROJECT-15H04702
  • [Presentation] 非プリン型キサンチン酸化還元酵素阻害剤(npXORI)によるアルツハイマー病モデル マウスの臨床症候学的改善効果の証明:アルツハイマー病新規治療薬開発への新戦略2018

    • Author(s)
      加藤 信介、加藤 雅子、西野 武士
    • Organizer
      日本痛風核酸代謝学会
    • Data Source
      KAKENHI-PROJECT-15H04702
  • [Presentation] プリン型キサンチン酸化還元酵素阻害剤(npXORI)によるアルツハイマー病モデル マウスの病理組織学的抑制効果の証明:アルツハイマー病新規治療薬開発への新戦略2018

    • Author(s)
      加藤 雅子、加藤 信介、岡本 研、西野 武士
    • Organizer
      日本痛風核酸代謝学会
    • Data Source
      KAKENHI-PROJECT-15H04702
  • [Presentation] The Strategy That Delays Progression of Neuro- Degenerative Diseases due to Accumulation of Misfolded Protein such as ALS and Alzheimer: Oral administration of xanthine oxidoreductase inhibitors that are not substrates for the purine salvage pathway to the transgenic mouse models.2017

    • Author(s)
      Takeshi Nishino
    • Organizer
      International Conference in Molybdenum and Tungsten Enzymes
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04702
  • [Presentation] Regulation of purine metabolism in rabbit reticulocytes2017

    • Author(s)
      Mai Sekine, T. Kusano, T. Nishino, K. Nagata, K. Okamoto
    • Organizer
      日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-15H04702
  • [Presentation] The Strategy That Delays Progression of Amyotrophic Lateral Sclerosis in G1H-G93A Transgenic Mice: Oral Administration of Xanthine Oxidoreductase Inhibitors that are Not Substrates for the Purine Salvage Pathway2017

    • Author(s)
      Takeshi Nishino
    • Organizer
      NeuroTalk2017
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04702
  • [Presentation] 日本の痛風・核酸代謝学会の特徴と果たす役割2017

    • Author(s)
      西野武士
    • Organizer
      日本痛風核酸代謝学会
    • Place of Presentation
      東京
    • Year and Date
      2017-02-16
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H04702
  • [Presentation] キサンチン酸化還元酵素基質結合ポケットの動的解析2016

    • Author(s)
      岡本研,菊地浩人, 藤崎弘士, 古田忠臣, 西野武士
    • Organizer
      第49回日本痛風・核酸代謝学会総会
    • Place of Presentation
      大阪府千里
    • Year and Date
      2016-02-19
    • Data Source
      KAKENHI-PROJECT-15H04702
  • [Presentation] キサンチン酸化還元酵素におけるAsp428はXDH/XO反応を巧妙に調節する重要アミノ酸である2016

    • Author(s)
      川口裕子、西野朋子、松村智裕、岡本研、西野武士
    • Organizer
      第49回日本痛風・核酸代謝学会総会
    • Place of Presentation
      大阪府千里
    • Year and Date
      2016-02-19
    • Data Source
      KAKENHI-PROJECT-15H04702
  • [Presentation] キサンチン脱水素酵素(XDH)のNAD+ の結合による反応調節2015

    • Author(s)
      川口 裕子1, 西野 朋子 , 岡本 研 , 西野 武士
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会
    • Place of Presentation
      神戸市ポートピア
    • Year and Date
      2015-12-04
    • Data Source
      KAKENHI-PROJECT-15H04702
  • [Presentation] The role of Asp428 in the reactivity of xanthine dehydrogenase2015

    • Author(s)
      Yuko Kawaguchi, Tomoko Nishino, Ken Okamoto, and Takeshi Nishino
    • Organizer
      IX. Molybdenum & Tungsten Enzymes Conference 2015
    • Place of Presentation
      Baratonfuered, Hungary
    • Year and Date
      2015-09-06
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04702
  • [Presentation] キサンチン酸化還元酵素の基質ガイド機構の解析2015

    • Author(s)
      岡本 研 , 菊地 浩人 , 藤崎 弘士 , 古田 忠臣 , 西野 武士
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会
    • Place of Presentation
      神戸市ポートピア
    • Year and Date
      2015-12-02
    • Data Source
      KAKENHI-PROJECT-15H04702
  • [Presentation] キサンチン酸化還元酵素の構造とプリン水酸化反応機構2013

    • Author(s)
      西野武士
    • Organizer
      第46回日本痛風核酸代謝学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24659144
  • [Presentation] キサンチン酸化還元酵素の構造とプリン水酸化反応機構2013

    • Author(s)
      西野武士
    • Organizer
      第46回日本痛風核酸代謝学会
    • Place of Presentation
      東京
    • Invited
    • Data Source
      KAKENHI-PROJECT-24659144
  • [Presentation] G1H-G93A遺伝子導入マウスの呈する筋萎縮性側索硬化症へのキサンチン酸化還元酵素阻害剤の影響2012

    • Author(s)
      草野輝男、加藤信介、加藤雅子、宮川拓也、西野武士
    • Organizer
      第85回日本生化学会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-24659144
  • [Presentation] G1H-G93A 遺伝子導入マウスの呈する筋萎縮性側索硬化症へのキサンチン酸化還元酵素阻害剤の影響2012

    • Author(s)
      草野輝男、加藤信介、加藤雅子、宮川拓也、西野武士
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-24659144
  • [Presentation] Reaction mechanism and substrate binding mode of xanthine oxidoreductase.2011

    • Author(s)
      Ken Okamoto、Yuko Kawaguchi、Teruo Kusano、Tomohiro Matsumura1、Koji Matsumoto、Takeshi Nishino
    • Organizer
      14th International Symposium on Purine and Pyrimidine Metabolism in Man
    • Place of Presentation
      東京
    • Year and Date
      2011-02-20
    • Data Source
      KAKENHI-PROJECT-20590317
  • [Presentation] 14th International Symposium on Purine and Pyrimidine Metabolism in Man Reaction mechanism and substrate binding mode of xanthine oxidoreductase.2011

    • Author(s)
      Ken Okamoto、Yuko Kawaguchi、Teruo Kusano、Tomohiro Matsumura 1、Koji Matsumoto、Takeshi Nishino
    • Data Source
      KAKENHI-PROJECT-20590317
  • [Presentation] ウシキサンチン酸化還元酵素と天然基質キサンチンとの反応中間体結晶構造Structure of xanthine oxidoreductase in action ; Reaction intermediate structure of milk xanthine oxidoreductase and natural substrate xanthine.2010

    • Author(s)
      Ken Okamoto, Tomohiro Matsumura, Kusano Teruo, Koji Matsumoto, Takeshi Nishino
    • Organizer
      2010年日本生化学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Data Source
      KAKENHI-PROJECT-20590317
  • [Presentation] 近赤外極微弱光検出装置を用いたヘムペルオキシダーゼ由来の一重項酸素の定量的測定法2009

    • Author(s)
      牧内正男, 辻田和宏, 草野輝男, 西野朋子, 柿沼カツ子
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-22
    • Data Source
      KAKENHI-PROJECT-20590317
  • [Presentation] ブチロフィリンが有す多機能B30.2/SPRYドメインとミルクキサンチン脱水素酵素との結合様式について2009

    • Author(s)
      西野朋子, 李穎, 岡本研, 草野輝男, 川口裕子, 松村智裕, 他
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-23
    • Data Source
      KAKENHI-PROJECT-20590317
  • [Presentation] キサンチン脱水素酵素から酸化酵素に変換する際の遷移状態における構造変2009

    • Author(s)
      西野朋子, 岡本研、川口裕子
    • Organizer
      蛋白質科学会
    • Data Source
      KAKENHI-PROJECT-20590317
  • [Presentation] キサンチン酸化還元酵素の基質結合様式と基質活性化機構2009

    • Author(s)
      岡本研, 松村智裕, 草野輝男, 松本浩二, 西野武士
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-23
    • Data Source
      KAKENHI-PROJECT-20590317
  • [Presentation] ラットキサンチン脱水素酵素におけるCH...O結合がFADの酸化還元電位に与える影響について2009

    • Author(s)
      川口裕子, 西野朋子, 松村智裕, 岡本研, 西野武士
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-23
    • Data Source
      KAKENHI-PROJECT-20590317
  • [Presentation] キサンチン酸化還元酵素の基質結合様式と基質活性化機構2009

    • Author(s)
      西野朋子, 岡本研、川口裕子
    • Organizer
      日本生化学会
    • Data Source
      KAKENHI-PROJECT-20590317
  • [Presentation] ラットキサンチン脱水素酵素における機能的CH...O水素結合の存在2009

    • Author(s)
      川口裕子, 西野朋子, 松村智裕, 岡本研, 西野武士
    • Organizer
      第9回蛋白質科学会年会
    • Place of Presentation
      熊本
    • Year and Date
      2009-05-20
    • Data Source
      KAKENHI-PROJECT-20590317
  • [Presentation] 新規キサンチン酸化還元酵素剤FYX-051の酵素学的,構造生物学的解析2009

    • Author(s)
      松本浩二, 岡本研, 松村智裕, 草野輝男, 西野武士
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-23
    • Data Source
      KAKENHI-PROJECT-20590317
  • [Presentation] knock-outマウスを用いたラクトペルオキシダーゼの組織局在の網羅的解析2009

    • Author(s)
      草野輝男, 松田陽子, 西野朋子, 石渡俊行, 内藤善哉, 西野武士
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-22
    • Data Source
      KAKENHI-PROJECT-20590317
  • [Presentation] 哺乳類ヘムペルオキシダーゼによる一重項酸素の生成2009

    • Author(s)
      辻田和宏, 草野輝男, 牧内正男, 西野朋子, 柿沼カツ子
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-22
    • Data Source
      KAKENHI-PROJECT-20590317
  • [Presentation] キサンチン脱水素酵素から酸化酵素に変換する際の遷移状態に於ける二量体サブユニット構造の非対称性2009

    • Author(s)
      西野朋子, 岡本研, 川口裕子, 辻井厚子, 他
    • Organizer
      第9回蛋白質科学会年会
    • Place of Presentation
      熊本
    • Year and Date
      2009-05-22
    • Data Source
      KAKENHI-PROJECT-20590317
  • [Presentation] New Application of Xanthine Oxidoreductase Inhibitors2008

    • Author(s)
      Takeshi Nishino
    • Organizer
      16^<th> International Symposioum on Flavins and Flavoproteins
    • Place of Presentation
      スペイン
    • Year and Date
      2008-06-08
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Presentation] キサンチンオキシダーゼによる活性酸素の生成機構2008

    • Author(s)
      西野武士
    • Organizer
      第15回マクロライド新作用研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-12
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Presentation] キサンチン脱水素酵素/酸化酵素の変換における二量体構造の非対称性2008

    • Author(s)
      西野朋子
    • Organizer
      第81回日本生化学大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-09
    • Data Source
      KAKENHI-PROJECT-20590317
  • [Presentation] New Application of Xanthine Oxidoreductase Inhibitors2008

    • Author(s)
      Takeshi Nishino
    • Organizer
      16^<th> International Symposium on Flavins and Flavoproteins
    • Place of Presentation
      Spain
    • Year and Date
      2008-06-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Presentation] 抗痛風薬の1つの利用法を例に本学会を考える2008

    • Author(s)
      西野武士
    • Organizer
      第41回日本痛風・核酸代謝学会
    • Place of Presentation
      福井
    • Year and Date
      2008-02-14
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Presentation] Insight into the significance of the society.A new therapeutic usage of anti-gout drugs2008

    • Author(s)
      Takeshi Nishino
    • Organizer
      41^<th> Annual meeting for gout and nucleic acid metabolism
    • Place of Presentation
      Fukui
    • Year and Date
      2008-02-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Presentation] Mechanism of formation of active oxygen species by xanthine oxidoreductase2008

    • Author(s)
      Takeshi Nishino
    • Organizer
      The 15^<th> meeting for newly found effect of macrolide drug
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-07-12
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Presentation] Old and new therapeutic drugs of anti-hyper uricemia2007

    • Author(s)
      Takeshi Nishino
    • Organizer
      40^<th> Annual meeting for gout and nucleic acid metabolism
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-02-15
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Presentation] 新旧高尿酸血症の治療薬2007

    • Author(s)
      西野武士
    • Organizer
      第40回日本痛風・核酸代謝学会
    • Place of Presentation
      東京
    • Year and Date
      2007-02-15
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Presentation] キサンチン脱水素酵素酸化酵素の変換機構/C末ペプチドの役割2007

    • Author(s)
      西野 朋子
    • Organizer
      第80回日本生化学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-11
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Presentation] The Molecular Mechanism of Transition from Xanthine Dehydrogenase to Xanthine Oxidase2007

    • Author(s)
      Takeshi Nishino
    • Organizer
      12th International Symposiumj on Purine and Pyrimidine Metabolism in Man
    • Place of Presentation
      アメリカ
    • Year and Date
      2007-06-24
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Presentation] キサンチン酸化還元酵素のミリブデン反応中心の構造:基質・阻害剤認識と反応機構2007

    • Author(s)
      西野武士
    • Organizer
      第45回日本生物物理学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-21
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Presentation] the structure of the molybdenum center, mechanism of molecular recognition of substrate & inhibitors, and hydroxylation reaction2007

    • Author(s)
      Takeshi Nishino
    • Organizer
      45^<th> Annual Meeting of Japanese Biophysical Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-12-21
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Presentation] The Molecular Mechanism of Transition from Xanthine Dehydrogenase to Xanthine Oxidase2007

    • Author(s)
      Takeshi Nishino
    • Organizer
      12th International Symposium on Purine and Pyrimidine Metabolism in Man
    • Place of Presentation
      アメリカ シカゴ
    • Year and Date
      2007-06-24
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Presentation] The Molecular Mechanism of Transition from Xanthine Dehydrogenase to Xanthine Oxidase2007

    • Author(s)
      Takeshi Nishino
    • Organizer
      12th International Symposium on Purine and Pyrimidine Metabolism in Man
    • Place of Presentation
      U.S.A
    • Year and Date
      2007-06-24
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Presentation] Therapeutic strategy with new drug against uric acid generation2006

    • Author(s)
      Takeshi Nishino
    • Organizer
      39^<th> Annual meeting for gout and nucleic acid metabolism
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-02-09
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Presentation] 新規尿酸生成阻害剤を用いた治療戦略2006

    • Author(s)
      西野武士
    • Organizer
      第39回日本痛風・核酸代謝学会
    • Place of Presentation
      京都
    • Year and Date
      2006-02-09
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Presentation] モリブドプテリン含有フラビン酵素であるキサンチン酸化還元酵素の構造・反応機構・調節機構と生理的意義2006

    • Author(s)
      西野武士
    • Organizer
      第20回プテリジンコンファレンス&第14回サイトカイン・ネオプテリン研究会第2回連合研究発表会
    • Place of Presentation
      東京
    • Year and Date
      2006-07-08
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Presentation] タンパク質の形と創薬2006

    • Author(s)
      西野武士
    • Organizer
      日本生化学会関東支部例会
    • Place of Presentation
      新潟
    • Year and Date
      2006-10-06
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Presentation] 種々の高尿酸血症治療薬をめざした阻害剤と蛋白質の複合体結晶構造解析から学ぶこと2006

    • Author(s)
      西野武士
    • Organizer
      第3回産学連携フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2006-02-22
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Presentation] Protein shape and drug design2006

    • Author(s)
      Takeshi Nishino
    • Organizer
      The Kanto-area Meeting of Japanese Biochemical Society
    • Place of Presentation
      Niigata
    • Year and Date
      2006-10-06
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Presentation] The Mammalian Xanthine Oxidoreductase : Mechanisms of Hydroxylation Reaction and Dehydrogenase/Oxidase Conversion2006

    • Author(s)
      Takeshi Nishino
    • Organizer
      Takeda Foundation for Scientific Reseach
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-04-10
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Presentation] Lessons from the crystal structures of the XOR protein bound with various inhibitors designed for anti-hyper uricemia2006

    • Author(s)
      Takeshi Nishino
    • Organizer
      The 3rd Forum for Cooperation within Academy and Industry
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-02-22
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Presentation] Purification and crystallization of complex flavoprotein having multiple reaction centers2006

    • Author(s)
      Takeshi Nishino
    • Organizer
      The 6^<th> Annual Meeting of Protein Science
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-04-24
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Presentation] 複合反応中心を持つ複合金属フラビン酵素の発現と精製と結晶化2006

    • Author(s)
      西野武士
    • Organizer
      第6回蛋白質科学会年会
    • Place of Presentation
      京都
    • Year and Date
      2006-04-24
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Presentation] Xanthine oxidase, a molybdopterin containing flavoprotein : structure, reaction mechanism regulation and physiological significance2006

    • Author(s)
      Takeshi Nishino
    • Organizer
      The 2^<nd> bound meeting of 2oth pterin society and 14^<th> cytokine and neopterin research organization
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-07-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Presentation] The Mammalian Xanthine Oxidoreductase : Mechanisms of Hydroxylation Reaction and Dehyrogenase/Oxidase Conversion2006

    • Author(s)
      Takeshi Nishino
    • Organizer
      武田科学振興財団シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2006-04-10
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Presentation] モリブデン配位子構造とキサンチン水酸化と機構2005

    • Author(s)
      西野武士
    • Organizer
      研究会「分子系の構造と電子状態」
    • Place of Presentation
      SPring-8
    • Year and Date
      2005-09-07
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Presentation] Mechanism of molybdenum-dependent hydroxylation : Crystal structure of reaction intermediate and roles of amino acid residues in the molybdenum active site2005

    • Author(s)
      Takeshi Nishino
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      イギリス
    • Year and Date
      2005-07-09
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Presentation] Structure of molybdenum ligands and mechanism of xanthine hydroxylation2005

    • Author(s)
      Takeshi Nishino
    • Organizer
      Structure and electronic state in molecular system
    • Place of Presentation
      Hyogo(SPring-8)
    • Year and Date
      2005-09-07
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16205021
  • [Presentation] Mechanism of molybdenum-dependent hydroxylation : Crystal structure of reaction intermediate and roles of amino acid residues in the molybdenum active site2005

    • Author(s)
      Takeshi Nishino
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      U.K
    • Year and Date
      2005-07-05
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16205021
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  • 2.  MATSUMURA Tomohiro (20297930)
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