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Oyama Fumitaka  小山 文隆

… Alternative Names

小山 文隆  オヤマ フミタカ

OYAMA Fumitaka  小山 文隆

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Researcher Number 40194641
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-1095-8306
Affiliation (Current) 2025: 工学院大学, 先進工学部, 教授
Affiliation (based on the past Project Information) *help 2023 – 2024: 工学院大学, 先進工学部, 教授
2016 – 2018: 工学院大学, 先進工学部, 教授
2009 – 2010: Kogakuin University, 工学部, 教授
2006 – 2008: 独立行政法人理化学研究所, 構造神経病理研究チーム, 研究員
2003: RIKEN (The Institute of Physical and Chemical Research), Brain Science Institute, Laboratory for Structural Neuropathology, Research Scientist, 構造神経病理研究チーム, 研究員 … More
2002: 理化学研究所, 構造神経病理研究チーム, 研究員
1998 – 2001: The Universi of Tokyo, Graduate School of Medicine, Lecturer, 大学院・医学系研究科, 講師
1997: 東京大学, 大学院医学系研究科, 講師
1996: 東京大学, 医学部, 講師
1994 – 1995: 東京大学, 医学部(医), 講師
1994: 東京大学, 医学部, 講師
1993 – 1994: 東京大学, 医学部脳研, 講師
1990: 藤田保健衛生大学, 医学部, 助手
1987 – 1989: 藤田学園保健衛生大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Nerve anatomy/Neuropathology / Nerve anatomy/Neuropathology / 老化(加齢) / Sections That Are Subject to Joint Review: Basic Section45010:Genetics-related ,Basic Section45020:Evolutionary biology-related / Basic Section 45010:Genetics-related / Basic Section 45020:Evolutionary biology-related / Applied biochemistry
Except Principal Investigator
物質生物化学 / Biological Sciences
Keywords
Principal Investigator
アルツハイマー病 / tau / lysosome / Alzheimer's disease / クロロキンミオパチー / タウ / 昆虫 / BACE1 / Gem GTPase / chloroquine myopathy … More / モデルマウス / ハンチントン病 / ナトリウムチャネルベータ4 / APP / ダウン症候群 / 家畜飼料化 / 変異体 / キメラ体 / 原因アミノ酸の同定 / 酵素の不活性化 / 反芻動物 / ウシ / 持続可能な食料生産 / 酸性キチナーゼ / 昆虫のキチン / 食性 / 哺乳類の進化 / 糖 / バイオマス / ペプシン / 酵素 / 食物繊維 / N-アセチル-D-グルコサミン (GlcNAc) / キチナーゼ / ブタ / マウス / 飼料 / 胃 / 消化酵素 / 新世界ザル / 旧世界ザル / マーモセット / カニクイザル / 家畜飼料 / プロテアーゼ耐性 / 糖質分解酵素 / キチン含有生物 / キチン / 酸性ほ乳類キチナーゼ / Neuritic degeneration / Transgenic mouse / Oligonucleotide array / Polyglutamine expansion / Neurodegenerative disorder / Sodium channel β4 subunit / Huntington disease / 発現抑制 / 投射ニューロン / トランスジェニックマウ / 線条体 / ナトリウムチャネルβ4 / 病態形成における役割 / 神経突起変性 / ポリグルタミン / オリゴヌクレオチドアレイ / 神経変性疾患 / cell elongation activity / transcriptome / tau deficient mouse / 細胞伸長活性 / トランスクリプトーム解析 / タウ欠損マウス / knockin mouse / Knockin mouse / RT-PCR法 / フローサイトメトリー / 遺伝子発現抑制 / ベータ4プロモーター / 蛍光タンパク質 / トランスジェニックマウス / mRNAレベル / Presenilin2 / リン酸化 / small tau / big tau / AD病変 / ApoE genotype / alternative splicing / 4-repeatタウ / APP-751 / upregulation … More
Except Principal Investigator
IIIa / 神経原線維変化 / アルツハイマー病 / 肝細胞癌 / 癌胎児性変化 / RNAスプライシング / フィブロネクチン / Asparagine(N)-linked Sugar Chain / Monoclonal Antibody / Ristocetin / Botrocetin / Glycoprotein(GP)IIb / Glycoprotein(GP)Ib / Platelet Aggregation / von Willebrand Factor / セリン結合糖鎖 / トレオニン / コラーゲン結合ドメイン / ヘパリン結合ドメイン / 血液凝固第VIII因子結合ドメイン / 血小板膜糖タンパク質 / フォンビルラント因子 / エピトープ / モノクロナール抗体 / ジスルヒド結合 / アミノ酸配列 / 血小板膜糖タンパク質(GP)Ib / フォルビルブラント因子 / 血小板膜GPIIb@IIIa / 血小板膜GPIb / アスパラギン結合糖鎖 / 単クロ-ン抗体 / リストセチン / ボトロセチン / 血小板膜GPIIb / 血小板膜GPlb / 血小板凝集 / フォンビルブラント因子 / Neuronal death / Neurofibrillary tangles / Tau / Alzheimer's disease / 神経細胞死 / タウ蛋白 / 第21染色体 / アポリポタンパクE4 / 神経成長抑制因子 / アミロイド前駆体タンパク / ダウン症 / アミロイド / アポリポタンパクE / 第14染色体 / 連鎖解析 / ポジショナルクローニング / 家族性アルツハイマー病 / 老人 / アルツハイマ-病 / 脳 / 選択的スプライシング / タウ / βーアミロイド蛋白質前駆体 / PHF / βアミロイド / 免疫組織化学 / テネイシン / 腎癌 / 肺癌 / 細胞外基質 Less
  • Research Projects

    (17 results)
  • Research Products

    (75 results)
  • Co-Researchers

    (26 People)
  •  Evolution of structure and function of acid chitinase (Chia): Promoting its use in livestock feed for insectsPrincipal Investigator

    • Principal Investigator
      小山 文隆
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 45020:Evolutionary biology-related
      Basic Section 45010:Genetics-related
      Sections That Are Subject to Joint Review: Basic Section45010:Genetics-related ,Basic Section45020:Evolutionary biology-related
    • Research Institution
      Kogakuin University
  •  Is acidic mammalian chitinase a major glycosidase in the stomachs of mouse and porcine?Principal Investigator

    • Principal Investigator
      Oyama Fumitaka
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied biochemistry
    • Research Institution
      Kogakuin University
  •  Downregulation of sodium channel β4 subunit in Huntington Disease transgenic micePrincipal Investigator

    • Principal Investigator
      OYAMA Fumitaka
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      The Institute of Physical and Chemical Research
  •  Pathological roles of sodium channel β4 subunit in Huntington disease transgenic micePrincipal Investigator

    • Principal Investigator
      OYAMA Fumitaka
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      The Institute of Physical and Chemical Research
  •  Identification of novel genes closely related to Alzheimer's diseasePrincipal Investigator

    • Principal Investigator
      OYAMA Fumitaka
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      RIKEN (The Institute of Physical and Chemical Research)
  •  Hyperphosphorylation and aggregation of tau protein, and neuronal death

    • Principal Investigator
      IHARA Yasuo
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      University of Tokyo
  •  Studies on the tau lysosomal proteolytic pathwayPrincipal Investigator

    • Principal Investigator
      OYAMA Fumitaka
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      University of Tokyo
  •  Studies on the tau lysosomal proteolytic pathwayPrincipal Investigator

    • Principal Investigator
      OYAMA Fumitaka
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      老化(加齢)
    • Research Institution
      The University of Tokyo
  •  アルツハイマー病原因遺伝子のヒト組織における発現制御Principal Investigator

    • Principal Investigator
      小山 文隆
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      老化(加齢)
    • Research Institution
      The University of Tokyo
  •  クロロキンミオパチーにおける細胞死の研究Principal Investigator

    • Principal Investigator
      小山 文隆
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  ダウン症候群患者脳におけるアルツハイマー病関連遺伝子の発現制御Principal Investigator

    • Principal Investigator
      小山 文隆
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      The University of Tokyo
  •  APPとタウ遺伝子のダウン症候群患者脳における発現制御Principal Investigator

    • Principal Investigator
      小山 文隆
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      The University of Tokyo
  •  アルツハイマー病の分子遺伝学的研究

    • Principal Investigator
      辻 省次
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Niigata University
  •  ヒト癌における組織特異的alternative splicingの脱制御の検証

    • Principal Investigator
      関口 清俊
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Fujita Health University
  •  アルツハイマ-病関連タンパク質mRNA前駆体の選択的スプライシングの脳での制御

    • Principal Investigator
      TITANI Koiti
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Fujita Health University
  •  ヒト癌におけるalternative splicingの脱制御の検証

    • Principal Investigator
      SEKIGUCHI Kiyotoshi
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Fujita Health University
  •  Studies on platelet aggregation by structural analysis of von Willebrand factor

    • Principal Investigator
      TITANI Koiti
    • Project Period (FY)
      1987 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      物質生物化学
    • Research Institution
      Fujita Health University

All 2023 2019 2018 2017 2016 2010 2009 2008 2007 2006 2004 2000

All Journal Article Presentation

  • [Journal Article] Evolutionary activation of acidic chitinase in herbivores through the H128R mutation in ruminant livestock2023

    • Author(s)
      Eri Tabata*, Ikuto Kobayashi, Takuya Morikawa, Akinori Kashimura, Peter O Bauer, Fumitaka Oyama
    • Journal Title

      iScience

      Volume: 26 Issue: 8 Pages: 107254-107254

    • DOI

      10.1016/j.isci.2023.107254

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22KJ2736, KAKENHI-PROJECT-23K27223
  • [Journal Article] High expression of acidic chitinase and chitin digestibility in the stomach of common marmoset (Callithrix jacchus), an insectivorous nonhuman primate2019

    • Author(s)
      Tabata, E., Kashimura, A., Uehara, M., Wakita, S., Sakaguchi, M., Sugahara, Y., Yurimoto, T., Sasaki, E., Matoska, V., Bauer, P. O. & Oyama, F.
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 159-159

    • DOI

      10.1038/s41598-018-36477-y

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18J23382, KAKENHI-PROJECT-16K07699
  • [Journal Article] Chitin digestibility is dependent on feeding behaviors, which determine acidic chitinase mRNA levels in mammalian and poultry stomachs2018

    • Author(s)
      Tabata, E., Kashimura, A., Kikuchi, A., Masuda, H., Miyahara, R., Hiruma, Y., Wakita, S., Ohno, M., Sakaguchi, M., Sugahara, Y., Matoska, V., Bauer, P. O. and Oyama, F.
    • Journal Title

      Sci. Rep.

      Volume: 8 Issue: 1 Pages: 1461-1461

    • DOI

      10.1038/s41598-018-19940-8

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07699, KAKENHI-PROJECT-18J23382
  • [Journal Article] Chitinase mRNA Levels Determined by QPCR in Crab-Eating Monkey (Macaca fascicularis) Tissues: Species-Specific Expression of Acidic Mammalian Chitinase and Chitotriosidase2018

    • Author(s)
      Uehara, M., Tabata, E., Ishii, K., Sawa, A., Ohno, M., Sakaguchi, M., Matoska, V., Bauer, P. O. & Oyama, F.
    • Journal Title

      Genes (Basel)

      Volume: 9 Issue: 5 Pages: 244-244

    • DOI

      10.3390/genes9050244

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07699
  • [Journal Article] Acidic chitinase-chitin complex is dissociated in a competitive manner by acetic acid: purification of natural enzyme for supplementation purposes2018

    • Author(s)
      Tabata, E., Kashimura, A., Wakita, S., Sakaguchi, M., Sugahara, Y., Imamura, Y., Shimizu, H., Matoska, V., Bauer, P. O. and Oyama, F.
    • Journal Title

      Int. J. Mol. Sci.

      Volume: 19 Issue: 2 Pages: 362-362

    • DOI

      10.3390/ijms19020362

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07699, KAKENHI-PROJECT-18J23382
  • [Journal Article] Improved fluorescent labeling of chitin oligomers: chitinolytic properties of acidic mammalian chitinase under somatic tissue pH conditions.2017

    • Author(s)
      Wakita, S., Kimura, M., Kato, N., Kashimura, A., Kobayashi, S., Kanayama, N., Ohno, M., Honda, S., Sakaguchi, M., Sugahara, Y., Bauer, P.O. and Oyama, F.
    • Journal Title

      Carbohydr. Polym.

      Volume: 164 Pages: 145-153

    • DOI

      10.1016/j.carbpol.2017.01.095

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07699
  • [Journal Article] Gastric and intestinal proteases resistance of chicken acidic chitinase nominates chitin-containing organisms for alternative whole edible diets for poultry.2017

    • Author(s)
      Tabata, E., Kashimura, A., Wakita, S., Ohno, M., Sakaguchi, M., Sugahara, Y., Kino, Y., Matoska, V., Bauer, P.O. and Oyama, F.
    • Journal Title

      Sci. Rep.

      Volume: 7 Issue: 1 Pages: 6662-6662

    • DOI

      10.1038/s41598-017-07146-3

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07699, KAKENHI-PROJECT-16K09683
  • [Journal Article] Mouse acidic mammalian chitinase exhibits transglycosylation activity at somatic tissue pH.2017

    • Author(s)
      Wakita S, Kobayashi S, Kimura M, Kashimura A, Honda S, Sakaguchi M, Sugahara Y, Kamaya M, Matoska V, Bauer PO, and Oyama F.
    • Journal Title

      FEBS Lett.

      Volume: 591 Issue: 20 Pages: 3310-3318

    • DOI

      10.1002/1873-3468.12798

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07699
  • [Journal Article] Protease resistance of porcine acidic mammalian chitinase under gastrointestinal conditions implies that chitin-containing organisms can be sustainable dietary resources2017

    • Author(s)
      Tabata, E., Kashimura, A., Wakita, S., Ohno, M., Sakaguchi, M., Sugahara, Y., Imamura, Y., Seki, S., Ueda, H., Matoska, V., Bauer, P. O. and Oyama, F.
    • Journal Title

      Sci. Rep.

      Volume: 7 Issue: 1 Pages: 12963-12963

    • DOI

      10.1038/s41598-017-13526-6

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07699, KAKENHI-PROJECT-17K07412
  • [Journal Article] Acidic mammalian chitinase is a proteases-resistant glycosidase in mouse digestive system.2016

    • Author(s)
      Ohno, M.; Kimura, M.; Miyazaki, H.; Okawa, K.; Onuki, R.; Nemoto, C.; Tabata, E.; Wakita, S.; Kashimura, A.; Sakaguchi, M.; Sugahara, Y.; Nukina, N.; Bauer, P. O.; Oyama, F.
    • Journal Title

      Sci. Rep.

      Volume: 6 Issue: 1 Pages: 37756-37756

    • DOI

      10.1038/srep37756

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07699
  • [Journal Article] Functional properties of mouse chitotriosidase expressed in the periplasmic space of Escherichia coli.2016

    • Author(s)
      Kimura, M.; Wakita, S.; Ishikawa, K.; Sekine, K.; Yoshikawa, S.; Sato, A.; Okawa, K.; Kashimura, A.; Sakaguchi, M.; Sugahara, Y.; Yamanaka, D.; Ohno, N.; Bauer, P. O.; Oyama, F.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 10 Pages: e0164367-e0164367

    • DOI

      10.1371/journal.pone.0164367

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07699
  • [Journal Article] Loss and gain of human acidic mammalian chitinase activity by nonsynonymous SNPs.2016

    • Author(s)
      Okawa, K.; Ohno, M.; Kashimura, A.; Kimura, M.; Kobayashi, Y.; Sakaguchi, M.; Sugahara, Y.; Kamaya, M.; Kino, Y.; Bauer, P. O.; Oyama, F.
    • Journal Title

      Mol. Biol. Evol.

      Volume: 33 Issue: 12 Pages: 3183-3193

    • DOI

      10.1093/molbev/msw198

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07699
  • [Journal Article] Functional reciprocity between Na+ channel Nav1.6 and beta1 subunits in the coordinated regulation of excitability and neurite outgrowth.2010

    • Author(s)
      Brackenbury W.J., Calhoun J.D., Chen C., Miyazaki H., Nukina N., Oyama F., Ranscht B., Isom L.L.
    • Journal Title

      Proc.Natl.Acad.Sci. USA. 107

      Pages: 2283-2288

    • Data Source
      KAKENHI-PROJECT-20500329
  • [Journal Article] Functional reciprocity between Na+ channel Nav1.6 and beta1 subunits in the coordinated regulation of excitability and neurite outgrowth.2010

    • Author(s)
      Brackenbury, W.J., Calhoun, J.D., Chen, C., Miyazaki, H., Nukina, N., Oyama, F., Ranscht, B., Isom, L.L.
    • Journal Title

      Proc.Natl.Acad.Sci.USA.

      Volume: 107 Pages: 2283-2288

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20500329
  • [Journal Article] Inhibition of rho-kinases enhances the degradation of mutant huntingtin.2009

    • Author(s)
      Bauer P.O., Wong HK., Oyama F., Goswami A., Okuno M., Kino Y., Miyazaki H., Nukina N.
    • Journal Title

      J.Biol.Chem. 284

      Pages: 13153-13164

    • Data Source
      KAKENHI-PROJECT-20500329
  • [Journal Article] Genetically determined differences in sodium current characteristics modulate conduction disease severity in mice with cardiac sodium channelopathy.2009

    • Author(s)
      Remme C.A., Scicluna B.S., Verkerk A.O., Amin A.S., Van Brunschot S., Beekman L., Deneer V.H.M., Chevalier C., Oyama F., Miyazaki H., Nukina N., Wilders R., Escande D., Houlgatte R., Wilde A.A.M., Tan H.L., Veldkamp M.W., de Bakker J.M.T., Bezzina C.R.
    • Journal Title

      Circulation Res. 104

      Pages: 1283-1292

    • Data Source
      KAKENHI-PROJECT-20500329
  • [Journal Article] A functional null mutation of SCN1B in a patient with Dravet syndrome.2009

    • Author(s)
      Patino G.A., Claes L.R., Lopez-Santiago L.F., Slat E.A., Dondeti R.S., Chen C., O'Malley H.A., Gray C.B., Miyazaki H., Nukina N., Oyama F., De Jonghe P., Isom L.L.
    • Journal Title

      J.Neurosci. 29

      Pages: 10764-10778

    • Data Source
      KAKENHI-PROJECT-20500329
  • [Journal Article] Suppression of mutant huntingtin aggregate formation by Cdk5/p35 through the effect on microtubule stability.2008

    • Author(s)
      Kaminosono S., Saito T., Oyama F., Ohshima T., Asada A., Nagai Y., Nukina N., Hisanaga S.
    • Journal Title

      J.Neurosci. 28

      Pages: 8747-8755

    • Data Source
      KAKENHI-PROJECT-20500329
  • [Journal Article] Mutant Huntingtin reduces HSP70 expression through the sequestration of NF-Y transcription factor.2008

    • Author(s)
      Yamanaka T., Miyazaki H., Oyama F., Kurosawa M., Washizu C., Doi H., Nukina N.
    • Journal Title

      EMBO J. 27

      Pages: 827-839

    • Data Source
      KAKENHI-PROJECT-20500329
  • [Journal Article] Floxed allele for conditional inactivation of the voltage-gated sodium channel β1 subunit Scnlb.2007

    • Author(s)
      Chen, C., Dickendesher, T. L., Oyama, F., Miyazaki, H., Nukina, N., Isom, L. L.
    • Journal Title

      Genesis. 45

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18500284
  • [Journal Article] N. : BACEI modulates filopodia-like protrusions induced by sodium channel β4 subunit.2007

    • Author(s)
      Miyazaki, H., Oyama, F., Wong, HK., Sakurai, T., Tamaoka, A., Nukina
    • Journal Title

      Biochem. Biophys. Res. Commun. 361

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18500284
  • [Journal Article] Sodium channel beta4 subunit : down-regulation and possible involvement in neuritic degeneration in Huntington's disease transgenic mice2006

    • Author(s)
      Oyama et al.
    • Journal Title

      Journal of Neurochemistry 98

      Pages: 518-529

    • Data Source
      KAKENHI-PROJECT-18500284
  • [Journal Article] N. : Sodium channel β4 : downregulated expression and possible involvement of neuritic degeneration in Huntington Disease transgenic mice.2006

    • Author(s)
      Oyama, F., Miyazaki, H., Sakamoto, N., Ikeda, T., Becquet, C., Machida, Y., Kaneko, K., Uchikawa, C., Suzuki, T., Kurosawa M., Tamaoka, A., Sakurai, T., Nukina
    • Journal Title

      J. Neurochem. 98

      Pages: 519-529

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18500284
  • [Journal Article] N. : rAAV-mediated shRNA reversed neuropathology in HD model mouse.2006

    • Author(s)
      Machida, Y., Okada, T., Kurosawa, M., Oyama, F., Ozawa, K., Nukina
    • Journal Title

      Biochem. Biophys. Res. Commun. 343

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18500284
  • [Journal Article] Sodium channel beta4 subunit : down-regulation and possible involvement in neuritic degeneration in Huntington's disease transgenic mice2006

    • Author(s)
      Oyama, et. al.
    • Journal Title

      Journal of Neurochemistry 98

      Pages: 518-529

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18500284
  • [Journal Article] Gem GTPase and tau : morphological changes induced by Gem GTPase in CHO cells are antagonized by tau.2004

    • Author(s)
      Oyama F, Kotliarova S, Harada A, Ito M, Miyazaki H, Ueyama Y, Hirokawa N, Nukina N, Ihara Y
    • Journal Title

      J Biol Chem 279

      Pages: 27272-27277

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12210005
  • [Journal Article] Gem GTPase and tau : morphological changes induced by gem GTPase in cho cells are antagonized by tau.2004

    • Author(s)
      Oyama F, et al.
    • Journal Title

      J Biol Chem 279・26

      Pages: 27272-27277

    • Data Source
      KAKENHI-PROJECT-12210005
  • [Journal Article] Gem GTPase and tau : morphological changes induced by Gem GTPase in CHO cells are antagonized by tau.2004

    • Author(s)
      Oyama F, et al.
    • Journal Title

      J Biol Chem 279

      Pages: 27272-27277

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-12210005
  • [Journal Article] Mutant-presenilin 2-transgenic mice : A large increase in the levels of Aβ42 is presumably associated with the low-density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin.2000

    • Author(s)
      Sawamura N, Morishima-Kawashima M, Waki H, Kobayashi K, Kuramochi T, Ito M, Oyama F, Ando S, Ihara Y
    • Journal Title

      J Biol Chem 275

      Pages: 27901-27908

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12210005
  • [Presentation] 反芻動物の酸性キチナーゼの活性化,2023

    • Author(s)
      田畑絵理、小林郁翔,森川卓也,樫村昭德,小山文隆
    • Organizer
      第37回日本キチン・キトサン学会大会
    • Data Source
      KAKENHI-PROJECT-23K27223
  • [Presentation] Engineering chimeric and mutant chitinase proteins to uncover the underlying mechanisms of decreased acidic chitinase activity in herbivorous animals2023

    • Author(s)
      Eri Tabata, Akinori Kashimura, Fumitaka Oyama
    • Organizer
      Engineering recombinant proteins for structural and functional studies
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K27223
  • [Presentation] The relationship of feeding behaviors and molecular evolution of acidic chitinase in Cetartiodactyla2023

    • Author(s)
      Eri Tabata, Akinori Kashimura, Fumitaka Oyama
    • Organizer
      Annual Meeting of Society for Molecular Biology and Evolution
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K27223
  • [Presentation] ブタ酸性キチナーゼは,消化器系プロテアーゼに耐性で,キチン分解酵素として機能する2019

    • Author(s)
      小山 文隆、樫村 昭徳、脇田 悟誌、菅原 康里、田畑 絵理
    • Organizer
      日本農芸化学会2019年度(H31年度)大会
    • Data Source
      KAKENHI-PROJECT-16K07699
  • [Presentation] Gene expression analysis of chitinases in crab-eating monkey: species-specific expression of acidic mammalian chitinase and chitotriosidase2018

    • Author(s)
      Uehara, M., Tabata, E., Ohno, M., Sakaguchi, M., Oyama, F.
    • Organizer
      14th International Chitin and Chitosan Conference (14th ICCC)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07699
  • [Presentation] Acidic chitinase mRNA levels and their chitinolytic activity are affected by the feeding behavior, which may determine chitin digestibility in animals2018

    • Author(s)
      Tabata, E., Kashimura, A., Wakita, S., Ohno, M., Sakaguchi, M., Sugahara, Y., Oyama, F.
    • Organizer
      14th International Chitin and Chitosan Conference (14th ICCC)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07699
  • [Presentation] Acidic mammalian chitinase is a major chitinase in stomach resistant to pepsin and trypsin/chymotrypsin digestion2018

    • Author(s)
      Oyama, F., Kimura, M., Okawa, K., Onuki, R., Nemoto, C., Tabata, E., Wakita, S., Kashimura, A., Sakaguchi, M., Sugahara, Y., Ohno, M.
    • Organizer
      14th International Chitin and Chitosan Conference (14th ICCC)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07699
  • [Presentation] Gene expression analysis of mammalian chitinases in common marmoset (Callithrix jacchus) tissue.2018

    • Author(s)
      Tabata, E., Kashimura, A., Uehara, M. Wakita, S., Sakaguchi, M., Sugahara, Y., Yurimoto, T., Sasaki, E., Oyama, F.
    • Organizer
      The 67th Annual Meeting of the American Society of Human Genetics
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07699
  • [Presentation] Feeding behaviors determine acidic chitinase mRNA levels in mammalian and poultry stomachs.2018

    • Author(s)
      Oyama, F., Kashimura, A., Kikuchi, A., Masuda, H., Miyahara, R., Hiruma, Y., Wakita, S., Ohno, M., Sakaguchi, M., Sugahara, Y., Tabata, E.
    • Organizer
      The 67th Annual Meeting of the American Society of Human Genetics
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07699
  • [Presentation] ヒト酸性ほ乳類キチナーゼの nonsynonymous SNPs による活性の調節2018

    • Author(s)
      小山文隆,大野美紗,樫村昭徳,木村将大,坂口政吉,菅原康里,大川一明
    • Organizer
      日本農芸化学会2018年度大会[名古屋]
    • Data Source
      KAKENHI-PROJECT-16K07699
  • [Presentation] Quantification of chitinases mRNA levels by qPCR in crab-eating monkey tissues: Comparison with mouse and human2018

    • Author(s)
      Uehara, M., Tabata, E., Ohno, M., Sakaguchi, M., Oyama, F.
    • Organizer
      The 67th Annual Meeting of the American Society of Human Genetics
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07699
  • [Presentation] ニワトリ酸性キチナーゼの消化酵素としての機能解析2018

    • Author(s)
      田畑絵理,樫村昭德,脇田悟誌,大野美紗,坂口政吉,菅原康里,小山文隆
    • Organizer
      日本農芸化学会2018年度大会[名古屋]
    • Data Source
      KAKENHI-PROJECT-16K07699
  • [Presentation] 2種類のマウスほ乳類キチナーゼのキチナーゼ活性比較2018

    • Author(s)
      木村将大,梅山隆敏,脇田悟誌,大川一明,坂口政吉,小山文隆
    • Organizer
      日本農芸化学会2018年度大会[名古屋]
    • Data Source
      KAKENHI-PROJECT-16K07699
  • [Presentation] Mechanistic insight of inactivation of mouse chitinase-like protein Ym12017

    • Author(s)
      Oyama, F., Sakaguchi, M., Sugahara, Y., Okawa, K.
    • Organizer
      The 67th Annual Meeting of the American Society of Human Genetics (ASHG) (Orlando)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07699
  • [Presentation] ヒト酸性ほ乳類キチナーゼの活性喪失とその活性化2017

    • Author(s)
      小山文隆
    • Organizer
      第6回 医薬工3大学 包括連携推進シンポジウム 特別講演(東京薬科大学)
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K07699
  • [Presentation] キチンオリゴ糖蛍光標識法を用いた酸性ほ乳類キチナーゼの特性解析2017

    • Author(s)
      脇田悟誌,木村将大, 樫村明徳, 坂口政吉, 菅原康里, 小山文隆
    • Organizer
      第31回日本キチン・キトサン学会大会
    • Data Source
      KAKENHI-PROJECT-16K07699
  • [Presentation] Chitinases mRNA levels quantified by qPCR in crab-eating monkey tissues.2017

    • Author(s)
      Kimura, M., Umeyama, T., Wakita, S., Okawa, K., Sakaguchi, M., Oyama, F.
    • Organizer
      The 67th Annual Meeting of the American Society of Human Genetics (ASHG) (Orlando)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07699
  • [Presentation] Gene expression analysis and enzyme function of pig mammalian chitinase2017

    • Author(s)
      Tabata, E., Kashimura, A., Wakita, S., Ohno, M., Sakaguchi, M., Sugahara, Y., Oyama, F.
    • Organizer
      The 67th Annual Meeting of the American Society of Human Genetics (ASHG) (Orlando)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07699
  • [Presentation] ニワトリ酸性キチナーゼの遺伝子発現解析とその酵素機能2017

    • Author(s)
      田畑絵理,樫村昭徳,脇田悟志,大野美紗,菅原康里,坂口政吉,小山文隆
    • Organizer
      第31回日本キチン・キトサン学会大会
    • Data Source
      KAKENHI-PROJECT-16K07699
  • [Presentation] カニクイザルにおけるキチナーゼ遺伝子の発現解析2017

    • Author(s)
      上原麻衣子,田畑絵里,大野美紗,坂口政吉,小山文隆
    • Organizer
      第31回日本キチン・キトサン学会大会
    • Data Source
      KAKENHI-PROJECT-16K07699
  • [Presentation] ヒト酸性ほ乳類キチナーゼの進化学的解析2017

    • Author(s)
      小山文隆,大野美紗,樫村昭徳,木村将大,坂口政吉,菅原康里,大川一明
    • Organizer
      第31回日本キチン・キトサン学会大会
    • Data Source
      KAKENHI-PROJECT-16K07699
  • [Presentation] マウスほ乳類キチナーゼの比較解析2017

    • Author(s)
      木村将大, 梅山隆敏, 脇田悟誌, 大川一明, 坂口政吉, 小山文隆
    • Organizer
      第31回日本キチン・キトサン学会大会
    • Data Source
      KAKENHI-PROJECT-16K07699
  • [Presentation] ニワトリ組織におけるキチナーゼ遺伝子発現レベルとその酵素学的機能の解析2017

    • Author(s)
      田畑絵理,樫村昭德,大野美紗,坂口政吉,小山文隆
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都市
    • Year and Date
      2017-03-18
    • Data Source
      KAKENHI-PROJECT-16K07699
  • [Presentation] マウス胃における酸性ほ乳類キチナーゼの発現と生産細胞の同定2016

    • Author(s)
      小山文隆,大野美紗,木村将大,大川一明,田畑絵理,脇田悟誌,樫村昭徳, 坂口政吉,菅原康里
    • Organizer
      第30回 日本キチン・キトサン学会大会
    • Place of Presentation
      川越市
    • Year and Date
      2016-08-19
    • Data Source
      KAKENHI-PROJECT-16K07699
  • [Presentation] Inactivation of mouse AMCase by introducing amino acid substitutions encoded by single-nucleotide polymorphisms in human AMCase gene.2016

    • Author(s)
      Oyama, F., Okawa, K., Ohno, M., Kashimura, A. Kobayashi, Y. Sakaguchi, M., Sugahara, Y.
    • Organizer
      The 66th Annual Meeting of the American Society of Human Genetics (ASHG)
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2016-10-19
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07699
  • [Presentation] Gene expression analysis of mammalian chitinase transcripts in pig tissues.2016

    • Author(s)
      Tabata, E., Ohno, M., Sakaguchi, M., Oyama, F.
    • Organizer
      The 66th Annual Meeting of the American Society of Human Genetics (ASHG)
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2016-10-20
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07699
  • [Presentation] ブタ組織におけるキチナーゼ遺伝子発現レベルの解析2016

    • Author(s)
      田畑絵理,大野美紗,坂口政吉,小山文隆
    • Organizer
      第30回 日本キチン・キトサン学会大会
    • Place of Presentation
      川越市
    • Year and Date
      2016-08-18
    • Data Source
      KAKENHI-PROJECT-16K07699
  • [Presentation] Correlation of nuclear accumulation of expanded polyglutamine and dysregulation of sodium channel beta4 subunit in Huntington disease transgenic mice2009

    • Author(s)
      F.Oyama, H. Miyazaki, M. Yamada, M. Kurosawa, Y. Kino, N. Nukina
    • Organizer
      The 59th Annual Meeting of the American Society of Human Genetics
    • Place of Presentation
      アメリカ合衆国、ハワイ州ホノルル市
    • Year and Date
      2009-10-23
    • Data Source
      KAKENHI-PROJECT-20500329
  • [Presentation] ポリグルタミン病の治療ターゲット探索のためのトランスジェニックマウスの開発・解析に関する研究厚生労働科学研究費補助金 運動失調症に関する調査研究2009

    • Author(s)
      小山文隆、宮崎晴子、山田みず樹、黒沢大、貫名信行
    • Organizer
      平成20年度班会議
    • Place of Presentation
      東京
    • Year and Date
      2009-01-16
    • Data Source
      KAKENHI-PROJECT-20500329
  • [Presentation] Correlation of nuclear accumulation of expanded polyglutamine and dysregulation of sodium channel beta4 subunit in Huntington disease transgenic mice2009

    • Author(s)
      Oyama, et al.
    • Organizer
      The 54th Annual Meeting of The American Society of Human Genetics
    • Place of Presentation
      Honolulu, Hawai, USA
    • Year and Date
      2009-10-23
    • Data Source
      KAKENHI-PROJECT-20500329
  • [Presentation] Downregulation of sodium channel β4 subunit in Huntington Disease transgenic mice2008

    • Author(s)
      Oyama, et al.
    • Organizer
      The 58th Annual Meeting of The American Society of Human Genetics
    • Place of Presentation
      Philadelphia, Pennsylvalnia, USA
    • Year and Date
      2008-11-14
    • Data Source
      KAKENHI-PROJECT-20500329
  • [Presentation] Downregulation of sodium channel β4 in Huntington Disease transgenic mice.2008

    • Author(s)
      小山文隆、宮崎晴子、黒沢大、山田みず樹、貫名信行
    • Organizer
      第31回日本神経科学大会、第31回大会
    • Year and Date
      2008-07-16
    • Data Source
      KAKENHI-PROJECT-20500329
  • [Presentation] Downregulation of sodium channel β4 subunit in Huntington Disease transgenic mice.2008

    • Author(s)
      F.Oyama, H. Miyazaki, M. Kurosawa, M. Yamada, N. Nukina
    • Organizer
      The 58th Annual Meeting of The American Society of Human Genetics
    • Place of Presentation
      アメリカ合衆国 ペンシルバニア州 フィラデルフィア市
    • Year and Date
      2008-11-12
    • Data Source
      KAKENHI-PROJECT-20500329
  • [Presentation] ハンチントン病トランスジェニックマウスにおけるナトリウムチャネルβ4サブユニットの発現抑制2008

    • Author(s)
      小山文隆, 他
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-10
    • Data Source
      KAKENHI-PROJECT-20500329
  • [Presentation] ハンチントン病モデルマウスにおけるナトリウムチャネルβ4サブユニットの発現抑制2007

    • Author(s)
      小山 文隆, 他
    • Organizer
      第30回日本神経科学学会
    • Place of Presentation
      横浜市
    • Year and Date
      2007-09-10
    • Data Source
      KAKENHI-PROJECT-18500284
  • [Presentation] BACE1 cleavage mediates neurite morphology induced by sodium channel β4 subunit.2007

    • Author(s)
      宮崎晴子、小山文隆、Hon-Kit Wong、金子貢巳、櫻井隆、玉岡晃、貫名信行
    • Organizer
      日本神経科学大会、第30回大会
    • Place of Presentation
      横浜市
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18500284
  • [Presentation] Dysregulation of β4 Gene Transcription in the Striatum of Huntington Disease Transgenic Mice2007

    • Author(s)
      Fumitaka Oyama, et. al.
    • Organizer
      The 57th Annual Meeting of The American Society of Human Genetics
    • Place of Presentation
      San Diego,California,
    • Data Source
      KAKENHI-PROJECT-18500284
  • [Presentation] BACE1 cleavage mediates neurite morphology induced by sodium channel β4 subunit.2007

    • Author(s)
      H. Miyazaki, F. Oyama. Hon-Kit Wong, K. Kaneko, T. Sakurai, A. Tamaoka, N. Nukina
    • Organizer
      The 30th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18500284
  • [Presentation] Dysregulation of β4 Gene Transcription in the Striatum of Huntington Disease Transgenic Mice2007

    • Author(s)
      Fumitaka Oyama, et. al.
    • Organizer
      The 57th Annual Meeting of The American Society of Human Genetics
    • Place of Presentation
      San Diego, California, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18500284
  • [Presentation] Dysregulation of sodium channel β4 expression in the striatum of Huntington Disease transgenic mice.2007

    • Author(s)
      F. Oyama, H. Miyazaki, M. Kurosawa, Takeshi Kaneko, Nobuyuki Nukina
    • Organizer
      The 57th Annual Meeting of The American Society of Human Genetics
    • Place of Presentation
      San Diego, California
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18500284
  • [Presentation] Dysregulation of β4 gene transcription in the striatum of Huntington Disease transgenic mice.2007

    • Author(s)
      小山文隆、宮崎晴子、黒沢大、玉岡晃、金子武嗣、貫名信行
    • Organizer
      日本神経科学大会、第30回大会、
    • Place of Presentation
      横浜市
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18500284
  • [Presentation] Dysregulation of β4 gene transcription in the striatum of Huntington Disease transgenic mice.2007

    • Author(s)
      F. Oyama, H. Miyazaki, M. Kurosawa, A. Tamaoka, Takeshi Kaneko, Nobuyuki Nukina
    • Organizer
      The 30th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18500284
  • [Presentation] Dysregulation of Sodium Channel β4 Subunit by Expanded Polyglutamine.2006

    • Author(s)
      F. Oyama, H. Miyazaki, K. Okamura, Y. Machida, M. Kurosawa, T. Sakurai, N. Nukina
    • Organizer
      The 56th Annual Meeting of The American Society of Huamn Genetics
    • Place of Presentation
      New Orleans, Louisiana
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18500284
  • [Presentation] Dysregulation of Sodium Channel β4 Subunit by Expanded Polyglutamine in Huntington Disease Transgenic Mice2006

    • Author(s)
      小山文隆、宮崎晴子、岡村和政、町田陽子、黒沢大、櫻井隆、貫名信行
    • Organizer
      日本神経科学大会、第29回大会
    • Place of Presentation
      京都市
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18500284
  • [Presentation] Dysregulation of Sodium Channel β4 Subunit by Expanded Polyglutamine,2006

    • Author(s)
      Fumitaka Oyama, et. al.
    • Organizer
      The 56th Annual Meeting of The American Society of Human Genetics
    • Place of Presentation
      New Orleans, Louisiana, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18500284
  • [Presentation] Dysregulation of Sodium Channel β4 Subunit by Expanded Polyglutamine in Huntington Disease Transgenic Mice.2006

    • Author(s)
      F. Oyama, H. Miyazaki, K. Okamura, Y. Machida, M. Kurosawa, T. Sakurai, N. Nukina
    • Organizer
      The 29th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18500284
  • 1.  IHARA Yasuo (60114386)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 2 results
  • 2.  SEKIGUCHI Kiyotoshi (50187845)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  TITANI Koiti (60179942)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  MORISHIMA Maho (50204722)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  FUNAMOTO Satoru (10345043)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  MIYASAKA Tomohiro (90342857)
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