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Ozaki Toshinori  尾崎 俊文

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OZAKI TOSHINORI  尾崎 俊文

OZAKI Toshinori  尾崎 俊文

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Researcher Number 40260252
Other IDs
Affiliation (Current) 2025: 千葉県がんセンター(研究所), 発がん制御研究部, 特任研究員
Affiliation (based on the past Project Information) *help 2025: 千葉県がんセンター(研究所), 発がん制御研究部, 特任研究員
2016 – 2020: 千葉県がんセンター(研究所), 発がん研究グループ DNA損傷シグナル研究室, 室長
2018: 千葉県がんセンター(研究所), がん予防センター 腫瘍ゲノム研究室, 客員研究員
2017: 千葉県がんセンター, 研究局, 室長
2015: 千葉県がんセンター(研究所), DNA 損傷シグナル研究室, 室長 … More
2013: 千葉県がんセンター(研究所), がん治療開発グループ, 研究員
2013: 千葉県がんセンター(研究所), その他部局等, 研究員
2012: 千葉県がんセンター(研究所), DNA損傷シグナル研究室, 室長
2011: 千葉県がんセンター(研究所), その他部局等, 研究員
2007: Chiba Cancer Center (Research Institute), Division of Biochemistry, Senior Researcher
2003 – 2006: 千葉県がんセンター(研究所), 生化学研究部, 上席研究員
2003 – 2004: 千葉県がんセンター, 生化学研究部, 上席研究員
2002: 千葉がんセンター, 生化学研究部, 上席研究員
1998 – 2000: 千葉県がんセンター, 研究局・生化学研究部, 研究員
1999: Chiba Cancer Center Research Institute, Department of Biochemistry, Senior Investigater
1994 – 1996: 千葉県がんセンター, 研究局・生化学研究部, 研究員 Less
Review Section/Research Field
Principal Investigator
Molecular biology / General medical chemistry / Basic Section 52050:Embryonic medicine and pediatrics-related / Experimental pathology / Tumor biology
Except Principal Investigator
Biological Sciences / Digestive surgery / Pediatric surgery / Basic Section 50020:Tumor diagnostics and therapeutics-related / Dermatology / Hygiene / Pathological medical chemistry
Keywords
Principal Investigator
p53 / apoptosis / DA41 / DAN / APP / AICD / UFD2a / RanBPM / proteasome / ubiquitin … More / E3 ligase / p73 / BMP4 / Two-hybrid / ゲムシタビン / TAp73 / TAp63 / 薬剤耐性 / 膵がん / 抗がん剤感受性 / 膵臓がん / RUNX2 / Alzheimer's disease / アルツハイマー / ubiquitination / NEDL2 / E2F1 / Growth suppression / 分泌蛋白質 / BMP2 / 細胞増殖抑制 / DA14 / ゲノム遺伝子 / Two-hybrid法 / がん抑制遺伝子 / 細胞周期 / 差し引きスクリーニング … More
Except Principal Investigator
p73 / p53 / p63 / 神経芽腫 / Neuroblastoma / MYCN / XCE / nestin / BMP2 / Mdm2 / 大腸がん / Survivin / GDNF / TrkA / apoptosis / regression / マイクロアレイ / Two-hybrid法 / ゲノム遺伝子 / DAN / 抗がん剤 / マウス皮下腫瘍モデル / 抗腫瘍薬 / ポリエチレングリコール誘導体 / 呼吸鎖複合体 / 神経芽腫細胞 / 増殖抑制効果 / ポリエチレングリコール / 有棘細胞癌 / 腫瘍関連遺伝子 / 有棘細胞がん / マウスモデル / ヒストン脱メチル化酵素 / 皮膚有棘細胞癌 / アルキル化剤 / ChB-PIP / PIポリアミド / 融合遺伝子 / 肝内胆管癌 / エピゲノム制御 / JHDM1B/KDM2B / 薬剤耐性 / JHDM1B / エピゲノム的制御 / 癌幹細胞 / CD 133 / Stem cell markers / Cancer stem cells / TUJ1 / CD133 / 幹細胞マーカー / がん幹細胞 / cDNA microarray / neuroblastoma / multi-drug resistance / シスプラチン耐性 / ΔNp73 / 多剤耐性 / Alcohol / MTHFR / Folic acid / Colorectal cancer / 葉酸代謝酵素(MTHFR) / 飲酒 / spoptosis / Neuroblatoma / 脳神経疾患 / 癌 / 発生・分化 / 遺伝子 / 1p36 / RanBPM / IKK / UFD2 / プロテアゾーム / UFD2a / NEDL2 / ユビキチンリガーゼ / HMGB2 / HMGB1 / MDM2 / E2F1 / c-Myc / MM1 / SAMドメイン / 転写制御 / PACK1 / c-Abl / インプリンティング / 遺伝子変異 / アポトーシス誘導 / 転写活性化 / 神経分化 / 分泌タンパク質 / 細胞周期 / がん抑制遺伝子 Less
  • Research Projects

    (25 results)
  • Research Products

    (109 results)
  • Co-Researchers

    (30 People)
  •  クルクミン誘導体-PIPを用いた骨肉腫制御戦略の構築Principal Investigator

    • Principal Investigator
      尾崎 俊文
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  Analysis of the mechanism of tumor specific growth inhibition by polyethylene glycol derivative PEG-X

    • Principal Investigator
      FUJIWARA Kyoko
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Nihon University
  •  Fundamental research on drug resistance mediated by epigenetic regulation and novel colorectal cancer stem cell targeted therapy

    • Principal Investigator
      SHIMOZATO OSAMU
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  Development of the alkylating agent targeting intrahepatic cholangiocarcinoma -specific fusion gene

    • Principal Investigator
      TAKAGI Keiko
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nihon University
  •  An enhancement in the sensitivity of refractory pancreatic cancer cells to anti-tumor drugs through the functional regulation of RUNX2.Principal Investigator

    • Principal Investigator
      OZAKI TOSHINORI
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  Searching for human SCC related gene aberrations by using Gasc1 knockout mice

    • Principal Investigator
      FUJIWARA Kyoko
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Nihon University
  •  Enhancement of drug-sensitivity through the reactivation of mutant p53Principal Investigator

    • Principal Investigator
      OZAKI TOSHINORI
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Tumor biology
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  Elucidation of the molecular mechanisms behind AICD-mediated neuronal apoptotic cell deathPrincipal Investigator

    • Principal Investigator
      OZAKI Toshinori
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  小児癌由来遺伝子材料を基盤とした疾病関連遺伝子の探索と病態解明への応用

    • Principal Investigator
      ICHIKAWA Miki
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  Identification of Cancer Stem Cells and Its Clinical Application for Treating Aggressive Neuroblastomas

    • Principal Investigator
      NAKAGAWARA Akira
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatric surgery
    • Research Institution
      Chiba Cancer Center Research Institute
  •  p53とp73の分解と安定化に基づく機能制御機構と発がん

    • Principal Investigator
      中川原 章
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  p73およびΔNp73の安定性によるp53の分子機構と発がん

    • Principal Investigator
      中川原 章
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  Role of p53 family genes in acquiring drug resistance of neuroblastoma.

    • Principal Investigator
      NAKAGAWARA Akira
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatric surgery
    • Research Institution
      Chiba Cancer Center Research Institute
  •  Negative regulation of p53 family protein p73 by transcription factor E2F-1Principal Investigator

    • Principal Investigator
      OZAKI Toshinori
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Chiba Cancer Center Research Institute
  •  ΔNp73によるp73およびp53の負の分子制御機構

    • Principal Investigator
      中川原 章
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  p53関連蛋白質p73およびp51/p63の構造と機能制御機構の解析

    • Principal Investigator
      中川原 章
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  新規がん抑制遺伝子p73の構造と機能の解析

    • Principal Investigator
      中川原 章
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  Molecular mechanism of spontaneous regression of neuroblastoma and its application to the therapy

    • Principal Investigator
      NAKAGAWA Akira
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Chiba Cancer Center Research Institute
  •  アルコール代謝ならびに葉酸代謝酵素の遺伝的多型と大腸がんに関する疫学的研究

    • Principal Investigator
      MURATA Motoi
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hygiene
    • Research Institution
      Chiba Cancer Center Research Institute
  •  Functional analysis of DAN and DA41 proteins in early embryogenesisPrincipal Investigator

    • Principal Investigator
      OZAKI Toshinori
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Molecular biology
    • Research Institution
      Chiba Cancer Center Research Institute
  •  新規がん抑制遺伝子DANおよびその産物の機能の解析

    • Principal Investigator
      崎山 樹
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  新規がん抑制遺伝子DANおよびその産物の機能の解析

    • Principal Investigator
      崎山 樹
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  STRUCTURAL AND FUNCTIONAL ANALYSIS OF A NEW CANDIDATE TUMOR-SUPPRESSOR GENE,DANPrincipal Investigator

    • Principal Investigator
      OZAKI Toshinori
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Molecular biology
    • Research Institution
      CHIBA CANCER CENTER RESEARCH INSTITUTE
  •  新規がん抑制遺伝子の単離とその性状の解析

    • Principal Investigator
      崎山 樹
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  細胞のがん化に関与する新規転写制御因子の解析Principal Investigator

    • Principal Investigator
      尾崎 俊文
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Molecular biology
    • Research Institution
      Chiba Cancer Center (Research Institute)

All 2018 2017 2016 2015 2014 2013 2012 2011 2008 2007 2006 2005 2004 2003 Other

All Journal Article Presentation

  • [Journal Article] Impact of RUNX2 gene silencing on the gemcitabine sensitivity of p53 mutated pancreatic cancer MiaPaCa 2 spheres.2018

    • Author(s)
      Sang M, Nakamura M, Ogata T, Sun D, Shimozato O, Nikaido T, Ozaki T.
    • Journal Title

      Oncol Rep.

      Volume: 印刷中 Pages: 2749-2758

    • DOI

      10.3892/or.2018.6344

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04980, KAKENHI-PROJECT-15K08412, KAKENHI-PROJECT-16K10559
  • [Journal Article] Hydrophobic structure of hairpin ten-ring pyrrole-imidazole polyamides enhances tumor tissue accumulation/retention in vivo2018

    • Author(s)
      Inoue Takahiro、Shimozato Osamu、Matsuo Nina、Mori Yusuke、Shinozaki Yoshinao、Lin Jason、Watanabe Takayoshi、Takatori Atsushi、Koshikawa Nobuko、Ozaki Toshinori、Nagase Hiroki
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 26 Issue: 9 Pages: 2337-2344

    • DOI

      10.1016/j.bmc.2018.03.029

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K10559, KAKENHI-PUBLICLY-16H01579, KAKENHI-PROJECT-16J05439, KAKENHI-PROJECT-15K08412, KAKENHI-PROJECT-17K15047, KAKENHI-PROJECT-17H03602
  • [Journal Article] Impact of RUNX2 on drug-resistant human pancreatic cancer cells with p53 mutations.2018

    • Author(s)
      Ozaki T, Yu M, Yin D, Sun D, Zhu Y, Bu Y, Sang M.
    • Journal Title

      BMC Cancer

      Volume: 18 Issue: 1 Pages: 309-309

    • DOI

      10.1186/s12885-018-4217-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08412
  • [Journal Article] Circulating autoantibodies against neuroblastoma suppressor of tumorigenicity 1 (NBL1): A potential biomarker for coronary artery disease in patients with obstructive sleep apnea.2018

    • Author(s)
      Matsumura T, Terada J, Kinoshita T, Sakurai Y, Yahaba M, Tsushima K, Sakao S, Nagashima K, Ozaki T, Kobayashi Y, Hiwasa T, Tatsumi K.
    • Journal Title

      PLOS One

      Volume: 13 Issue: 3 Pages: 1-1

    • DOI

      10.1371/journal.pone.0195015

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09528, KAKENHI-PROJECT-15K08412
  • [Journal Article] Depletion of runt-related transcription factor 2 (RUNX2) enhances SAHA sensitivity of p53-mutated pancreatic cancer cells through the regulation of mutant p53 and TAp63.2017

    • Author(s)
      Ogata T, Nakamura M, Sang M, Yoda H, Hiraoka K, Yin D, Sang M, Shimozato O, Ozaki T.
    • Journal Title

      PLoS One

      Volume: 12 Issue: 7 Pages: e0179884-e0179884

    • DOI

      10.1371/journal.pone.0179884

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08412
  • [Journal Article] Drug resistance of cancer stem cell.2017

    • Author(s)
      Osamu Shimozato, Masashi Matsushita, Kyosuke Uchiumi, Yusuke Mori, Meijie Sang, Toshinori Ozaki
    • Journal Title

      BIO Clinica

      Volume: 32 Pages: 53-58

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K10559
  • [Journal Article] Autonomous feedback loop of RUNX1-p53-CBFB in acute myeloid leukemia cells.2017

    • Author(s)
      Morita K, Noura M, Tokushige C, Maeda S, Kiyose H, Kashiwazaki G, Taniguchi J, Bando T, Yoshida K, Ozaki T, Matsuo H, Ogawa S, Liu PP, Nakahata T, Sugiyama H, Adachi S, Kamikubo Y.
    • Journal Title

      Sci Rep.

      Volume: 7(1) Issue: 1 Pages: 16604-16604

    • DOI

      10.1038/s41598-017-16799-z

    • NAID

      120006368172

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19193, KAKENHI-PROJECT-15K08412, KAKENHI-PROJECT-17H04110
  • [Journal Article] Depletion of TFAP2E attenuates adriamycin-mediated apoptosis in human neuroblastoma cells.2017

    • Author(s)
      Hoshi R, Watanabe Y, Ishizuka Y, Hirano T, Nagasaki-Maeoka E, Yoshizawa S, Uekusa S, Kawashima H, Ohashi K, Sugito K, Fukuda N, Nagase H, Soma M, Ozaki T, Koshinaga T and Fujiwara K.
    • Journal Title

      ONCOLOGY REPORTS

      Volume: 37 Issue: 4 Pages: 2459-2464

    • DOI

      10.3892/or.2017.5477

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290060, KAKENHI-PROJECT-26462718, KAKENHI-PROJECT-15K08412
  • [Journal Article] Depletion of pro-oncogenic RUNX2 enhances gemcitabine (GEM) sensitivity of p53-mutated pancreatic cancer Panc-1 cells through the induction of pro-apoptotic TAp63.2016

    • Author(s)
      Ozaki T, Nakamura M, Ogata T, Sang M, Yoda H, Hiraoka K, Sang M, Shimozato O.
    • Journal Title

      Oncotarget

      Volume: 7 Issue: 44 Pages: 71937-71950

    • DOI

      10.18632/oncotarget.12433

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08412
  • [Journal Article] High mutation levels are compatible with normal embryonic development in Mlh1-deficient mice.2016

    • Author(s)
      Fan X, Li Y, Zhang C, Sang M, Cai J, Li Q, Ozaki T, Ono T, He D.
    • Journal Title

      Radiat. Res.

      Volume: 186 Pages: 377-384

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08412
  • [Journal Article] Improvement of gemcitabine sensitivity of p53-mutated pancreatic cancer MiaPaCa-2 cells by RUNX2 depletion-mediated augmentation of TAp73-dependent cell death.2016

    • Author(s)
      Nakamura M, Sugimoto H, Ogata T, Hiraoka K, Yoda H, Sang M, Sang M, Zhu Y, Yu M, Shimozato O, Ozaki T.
    • Journal Title

      Oncogenesis

      Volume: 5 Issue: 6 Pages: e233-e233

    • DOI

      10.1038/oncsis.2016.40

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08412
  • [Journal Article] Transcriptional regulation of BMCC1 mediated by E2F1 in neuroblastoma cells2016

    • Author(s)
      Mohammad Sazzadul Islam, Yasutoshi Tatsumi, Ryo Takano, Tomoki Yokochi, Jesmin Akter, Toshinori Ozaki, Yohko Nakamura, Miki Ohira, and Akira Nakagawara
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 478 Issue: 1 Pages: 81-86

    • DOI

      10.1016/j.bbrc.2016.07.089

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461602, KAKENHI-PROJECT-26461603, KAKENHI-PROJECT-15K08412, KAKENHI-PROJECT-15K08720
  • [Journal Article] Silencing of RUNX2 enhances gemcitabine sensitivity of p53-deficient human pancreatic cancer AsPC-1 cells through the stimulation of TAp63-mediated cell death.2015

    • Author(s)
      Sugimoto H, Nakamura M, Yoda H, Hiraoka K, Shinohara K, Sang M, Fujiwara K, Shimozato O, Nagase H, Ozaki T.
    • Journal Title

      Cell Death Discovery

      Volume: 6 Issue: 10 Pages: e1914-e1914

    • DOI

      10.1038/cddis.2015.242

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08412, KAKENHI-PROJECT-26350977, KAKENHI-ORGANIZER-25112001, KAKENHI-PUBLICLY-26112517, KAKENHI-PROJECT-26290060
  • [Journal Article] Runt-related transcription factor 2 (RUNX2) attenuates the transcriptional activity as well as DNA damage-mediated induction of pro-apoptotic TAp73 to regulate chemo-sensitivity2015

    • Author(s)
      Ozaki T, Sugimoto H, Nakamura M, Hiraoka K, Yoda H, Sang M, Fujiwara K, Nagase H.
    • Journal Title

      FEBS Journal

      Volume: 82 Issue: 1 Pages: 114-28

    • DOI

      10.1111/febs.13108

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-25112001, KAKENHI-PUBLICLY-25134718, KAKENHI-PUBLICLY-26112517, KAKENHI-PROJECT-26290060, KAKENHI-PROJECT-15K08412
  • [Journal Article] Inhibition of malignant phenotypes of human osteosarcoma cells by a gene silencer, a pyrrole-imidazole polyamide, which targets E-box.2014

    • Author(s)
      134. Taniguchi M, Nakai Y, Ozaki T, Koshikawa N, Kojima T, Kataba M, Oguni A, Matsuda H, Yoshida Y, Tokuhashi Y, Fukuda N, Ueno T, Soma T, Nagase H.
    • Journal Title

      FEBS Open Bio

      Volume: 4 Issue: 1 Pages: 328-334

    • DOI

      10.1016/j.fob.2014.03.004

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23300344, KAKENHI-PROJECT-23501278, KAKENHI-PROJECT-23501313, KAKENHI-PUBLICLY-25134718, KAKENHI-PUBLICLY-26112517, KAKENHI-PROJECT-26290060
  • [Journal Article] Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole-imidazole polyamide conjugate.2014

    • Author(s)
      Hiraoka K, Inoue T, Taylor RD, Watanabe T, Koshikawa N, Yoda H, Shinohara K, Takatori A, Sugimoto H, Maru Y, Denda T, Fujiwara K, Balmain A, Ozaki T, Bando T, Sugiyama H, Nagase H.
    • Journal Title

      Nat. Commun.

      Volume: 6 Issue: 1 Pages: 6706-6706

    • DOI

      10.1038/ncomms7706

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-25112001, KAKENHI-PUBLICLY-25134718, KAKENHI-PROJECT-25871150, KAKENHI-PUBLICLY-26112517, KAKENHI-PROJECT-26290060, KAKENHI-PROJECT-15K08412, KAKENHI-PROJECT-26350977, KAKENHI-PROJECT-25461573, KAKENHI-PROJECT-24310155, KAKENHI-PROJECT-24225005
  • [Journal Article] Inhibition of malignant phenotypes of human osteosarcoma cells by a gene silencer Pyrrole-Imidazole polyamide targeting E-box2014

    • Author(s)
      Taniguchi M, Fujiwara K, Nakai Y, Ozaki T, Koshikawa N, Kojima T, Kataba M, Oguni A, Matsuda H, Yoshida Y, Tokuhashi Y, Fukuda N, Ueno T, Soma M, and Nagase H
    • Journal Title

      FEBS Open Bio

      Volume: 4 Pages: 328-334

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23501278
  • [Journal Article] Receptor-type protein tyrosine phosphatasedirectly dephosphorylates CD133 and regulates downstream AKT activation2014

    • Author(s)
      Shimozato O, Souda H
    • Journal Title

      Oncogene

      Volume: 34(15) Issue: 15 Pages: 1-12

    • DOI

      10.1038/onc.2014.141

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23591978, KAKENHI-PROJECT-24249061, KAKENHI-PROJECT-24390269, KAKENHI-PROJECT-26462721, KAKENHI-PROJECT-15K08412
  • [Journal Article] Receptor-type protein tyrosine phosphatase κ (PTPRK) directly dephosphorylates CD133 and regulates downstream AKT activation.2014

    • Author(s)
      Shimozato O, Waraya M, Nakashima K, Soda H, Takiguchi N, Yamamoto H, Takenobu H, Uehara H, Ikeda E, Matsushita S, Kubo N, Nakagawara A, Ozaki T, Kamijo T.
    • Journal Title

      Oncogene

      Volume: 未定

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23501278
  • [Journal Article] Receptor-type protein tyrosine phosphatase к (PTPRK) directly dephosphorylates CD133 and regulates downstream AKT activation2014

    • Author(s)
      Shimozato O, Waraya M, Nakashima K, Soda H, Takiguchi N, Yamamoto H, Takenobu H, Uehara H, Ikeda E, Matsushita S, Kubo N, Nakagawara A, Ozaki T, Kamijo T
    • Journal Title

      Oncogene

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23501278
  • [Journal Article] Runt-related transcription factor 2 (RUNX2) inhibits p53- dependent apoptosis through the collaboration with HDAC6 in response to DNA damage.2013

    • Author(s)
      Ozaki T, Wu D, Sugimoto H, Nagase H, Nakagawara A.
    • Journal Title

      Cell Death Dis.

      Volume: e610 Issue: 4 Pages: e610-e610

    • DOI

      10.1038/cddis.2013.127

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23501278, KAKENHI-PROJECT-24249061
  • [Journal Article] NFBD1/MDC1 is phosphorylated by PLK1 and controls G2/M transition through the regulation of a TOPOIIα-mediated decatenation checkpoint2013

    • Author(s)
      Ando K, Ozaki T, Hirota T, Nakagawara A
    • Journal Title

      PLoS One

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23501278
  • [Journal Article] Dependence receptor UNC5D mediates nerve growth factor depletion-induced neuroblastoma regression.2013

    • Author(s)
      Zhu Y, Li Y, Haraguchi S, Yu M, Ohira M, Ozaki T, Nakagawa A, Ushijima T, Isogai E, Koseki H, Nakamura Y, Kong C, Mehlen P, Arakawa H, Nakagawara A.
    • Journal Title

      J Clin Invest.

      Volume: 123 Issue: 7 Pages: 2935-47

    • DOI

      10.1172/jci65988

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249015, KAKENHI-PROJECT-23501278, KAKENHI-PROJECT-23591562, KAKENHI-PROJECT-24249061, KAKENHI-PROJECT-24591566, KAKENHI-PROJECT-24592703, KAKENHI-PROJECT-25670169
  • [Journal Article] Dependence receptor UNC5D mediates nerve growth factor depletion-induced neuroblastoma regression2013

    • Author(s)
      Zhu Y, Li Y, Haraguchi S, Yu M, Ohira M, Ozaki T, Nakagawara A, Ushijima T, Isogai E, Koseki H, Nakamura Y, Kong C, Mehlen P, Arakawa H, Nakagawara A
    • Journal Title

      J. Clin. Invest.

      Volume: 123 Pages: 2935-2947

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23501278
  • [Journal Article] NFBD1/MDC1 is phosphorylated by PLK1 and controls G2/M transition through the regulation of a TOPOIIα-mediated decatenation checkpoint.2013

    • Author(s)
      Ando K, Ozaki T, Hirota T, Nakagawara A.
    • Journal Title

      PLoS One

      Volume: e82744 Issue: 12 Pages: 0-0

    • DOI

      10.1371/journal.pone.0082744

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23501278, KAKENHI-PUBLICLY-24114517, KAKENHI-PROJECT-24249061, KAKENHI-PROJECT-24370076, KAKENHI-PROJECT-25893292
  • [Journal Article] Co-chaperon DnaJC7/TPR2 enhances p53 stability and activity through blocking the complex formation between p53 and MDM22013

    • Author(s)
      Kubo N, Wu D, Yoshihara Y, Sang M, Nakagawara A, Ozaki T
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 430 Pages: 1034-1039

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23501278
  • [Journal Article] Co-chaperon DnaJC7/TPR2 enhances p53 stability and activity through blocking the complex formation between p53 and MDM2.2013

    • Author(s)
      Kubo N, Wu D, Yoshihara Y, Sang M, Nakagawara A, Ozaki T.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 430 Issue: 3 Pages: 1034-1039

    • DOI

      10.1016/j.bbrc.2012.11.121

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23501278, KAKENHI-PROJECT-24249061
  • [Journal Article] Runt-related transcription factor 2 (RUNX2) inhibits p53-dependent apoptosis through the collaboration with HDAC6 in response to DNA damage2013

    • Author(s)
      Ozaki T,Wu D, Sugimoto H, Nagase H, Nakagawara A
    • Journal Title

      Cell Death Dis.

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23501278
  • [Journal Article] p53 依存性のDNA 損傷応答機構における RUNX2 の新たな役割2013

    • Author(s)
      尾崎俊文、永瀬浩喜、中川原章
    • Journal Title

      生化学

      Volume: 未定

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23501278
  • [Journal Article] Runt-related transcription factor 2 (RUNX2) inhibits p53- dependent apoptosis through the collaboration with HDAC6 in response to DNA damage.2013

    • Author(s)
      Ozaki T, Wu D, Sugimoto H, Nagase H, Nakagawara A.
    • Journal Title

      Cell Death Disease

      Volume: 未定

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23501278
  • [Journal Article] Co-chaperon DnaJC7/TPR2 enhances p53 stability and activity through blocking the complex formation between p53 and MDM2.2013

    • Author(s)
      Kubo N, Wu D, Yoshihara Y, Sang M, Nakagawara A, Ozaki T.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 430 Pages: 1034-1039

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23501278
  • [Journal Article] Runt-related transcription factor 1 (RUNX1) stimulates tumor suppressor p53 in response to DNA damage through complex formation and acetylation.2013

    • Author(s)
      Wu D, Ozaki T, Yoshihara Y, Kubo N, Nakagawara A.
    • Journal Title

      J. Biol. Chem.

      Volume: 288 Pages: 1353-1364

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23501278
  • [Journal Article] Inhibitory role of E2F-1 in the regulation of tumor suppressor p53 during DNA damage response2012

    • Author(s)
      Yoshihara Y, Wu D, Kubo N, Sang M, Nakagawara A, Ozaki T
    • Journal Title

      Biochem, Biophys, Res. Commun.

      Volume: 421 Pages: 57-63

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23501278
  • [Journal Article] CREB represses p53-dependent transactivation of MDM2 through the complex formation with p53 and contributes to p53-mediated apoptosis in response to glucose deprivation2011

    • Author(s)
      Okoshi R, Kubo N, Nakashima K, Shimozato O, Nakagawara A, Ozaki T
    • Journal Title

      Biochem, Biophys, Res. Commun.

      Volume: 406 Pages: 79-84

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23501278
  • [Journal Article] DNA損傷刺激に応答したp53の活性化機構におけるRUNX3の新たな役割とアポトーシス誘導2011

    • Author(s)
      尾崎俊文、山田千寿、中川原章
    • Journal Title

      生化学

      Volume: 83 Pages: 751-754

    • NAID

      10029575150

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23501278
  • [Journal Article] Role of p53 in cell death and human cancers2011

    • Author(s)
      Ozaki T, Nakagawara A
    • Journal Title

      Cancers

      Volume: 3 Pages: 994-1013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23501278
  • [Journal Article] p73 and MDM2 confer the resistance of epidermoid carcinoma to cisplatin by blocking p53.2006

    • Author(s)
      Hayashi S, Ozaki Y, Yoshida K, Hosoda M, Todo S, Akiyama S, Nakagawara A.
    • Journal Title

      Biochem Biophys Res Commun. 347

      Pages: 60-66

    • Data Source
      KAKENHI-PROJECT-18590279
  • [Journal Article] p73-dependent induction of 14-3-3o increases the chemo-sensitivity of drug-resistant human breast cancers.2006

    • Author(s)
      Sang M, Li Y, Ozaki T, Ono S, Ando K, Yamamoto H, Koda T, Geng C, Nakagawara A
    • Journal Title

      Biochem Biophys Res Commun. 347

      Pages: 327-333

    • Data Source
      KAKENHI-PROJECT-18590279
  • [Journal Article] Bcl-2 is a key regulator for the retinoic acid-induced apoptotic cell death in neuroblastoma.2006

    • Author(s)
      Niizuma H, Nakamura Y, Ozaki T, Ohira M, Isogai E, Kageyama H, Imaizumi M, Nakagawara A.
    • Journal Title

      Oncogene

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390473
  • [Journal Article] The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis.2006

    • Author(s)
      Ozaki T, Li Y, Miyazaki K, Tomita T, Iwatsubo T, Nakagawara A
    • Journal Title

      Biochem Biophys Res Commun. 351

      Pages: 57-63

    • Data Source
      KAKENHI-PROJECT-18590279
  • [Journal Article] NF-kB regulates the stability and activity of p73 by inducing its proteolytic degradation through a ubiquitin-dependent proteasome pathway.2006

    • Author(s)
      Kikuchi H, Ozaki T, Furuya K, Hanamoto T, Nakanishi M, Yamamoto H, Yoshida K, Todo S, Nakagawara A.
    • Journal Title

      Oncogene 25

      Pages: 7608-7617

    • Data Source
      KAKENHI-PROJECT-18590279
  • [Journal Article] Bcl-2 is a key regulator for the retinoic acid-induced apoptotic cell death in neuroblastoma.2006

    • Author(s)
      Niizuma H, Nakamura Y, Ozaki T, Ohira M, Isogai E, Kageyama H, Imaizumi M, Nakagawara A.
    • Journal Title

      Oncogene 25

      Pages: 5046-5055

    • Data Source
      KAKENHI-PROJECT-18590279
  • [Journal Article] The intracellular domain of the amyloid precursor protein(AICD) enhances the p53-mediated apoptosis.2006

    • Author(s)
      Ozaki, et. al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 351

      Pages: 57-63

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590279
  • [Journal Article] p73, a sophisticated p53 family memberin the cancer world.2005

    • Author(s)
      Ozaki T, Nakagawara A. et al.
    • Journal Title

      Cancer Sci. 96

      Pages: 729-737

    • Data Source
      KAKENHI-PROJECT-17390473
  • [Journal Article] Identification of protein kinase A catalytic subunit β(PKA-Cβ) as a novel binding partner of p73 and regulation of p73 function.2005

    • Author(s)
      Hanamoto, T., Ozaki, T., et al.
    • Journal Title

      J.Biol.Chem. 280

      Pages: 16665-16675

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590261
  • [Journal Article] Protein stability and function of p73 are modulated by a physical interaction with RanBPM in mammalian cultured cells.2005

    • Author(s)
      Kramer S, Ozaki T, Miyazaki K, Kato C, Hanamoto T, Nakagawara A.
    • Journal Title

      Oncogene 24

      Pages: 938-944

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390535
  • [Journal Article] Identification of protein kinase A catalytic subunit b (PKA-Cb) as a novel binding partner of p73 and regulation of p73 function.2005

    • Author(s)
      Hanamoto T, Ozaki T, Furuya K, Hosoda M, Hayashi S, Nakanishi M, Yamamoto H, Kikuchi H, Todo S, Nakagawara A.
    • Journal Title

      J.Biol.Chem. 280

      Pages: 16665-16675

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390535
  • [Journal Article] LMO3 interacts with neuronal transcription factor, HEN2,and acts as an oncogene in neuroblastoma.2005

    • Author(s)
      Aoyama M, Ozaki T, Inuzuka H, Tomotsune D, Hirato J, Okamoto Y, Tokita H, Ohira M, Nakagawara A.
    • Journal Title

      Cancer Res. 65

      Pages: 4587-4597

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390535
  • [Journal Article] Functional implication of p73 protein stability in neuronal cell survival and death2005

    • Author(s)
      Ozaki T, Nakagawara A. et al.
    • Journal Title

      Cancer Lett 228

      Pages: 29-35

    • Data Source
      KAKENHI-PROJECT-17390473
  • [Journal Article] LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma.2005

    • Author(s)
      Aoyama, M., Ozaki, T., et al.
    • Journal Title

      Cancer Res. (in press)

    • Data Source
      KAKENHI-PROJECT-15590261
  • [Journal Article] Identification of protein kinase A catalytic subunit β (PKA-Cβ) as a novel binding partner of p73 and regulation of p73 function.2005

    • Author(s)
      Hanamoto, T., Ozaki, T., Furuya, K., Hosoda, M., Hayashi, S., Nakanishi, M., Yamamoto, H., Kikuchi, H., Todo, S., Nakagawara, A.
    • Journal Title

      J.Biol.Chem. 280

      Pages: 16665-16675

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590261
  • [Journal Article] Topors, a p53 topoisomerase I-binding RING finger protein, is a co-activator of p53 in growth suppression induced by DNA damage.2005

    • Author(s)
      Lin, L., Ozaki, T., et al.
    • Journal Title

      Oncogene (in press)

    • Data Source
      KAKENHI-PROJECT-15590261
  • [Journal Article] LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma.2005

    • Author(s)
      Aoyama M, Ozaki T, Inuzuka H, Tomotsune D, Hirato J, Okamoto Y, Tokita H, Ohira M, Nakagawara A.
    • Journal Title

      Cancer Res.

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390473
  • [Journal Article] Protein stability and function of p73 are modulated by a physical interaction with RanBPM in mammalian cultured cells.2005

    • Author(s)
      Kramer, S., Ozaki, T., et al.
    • Journal Title

      Oncogene 24

      Pages: 938-944

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590261
  • [Journal Article] Topors, a p53 and topoisomerase I-binding RING finger protein, is a co-activator of p53 in growth suppression induced by DNA damage.2005

    • Author(s)
      Lin L, Ozaki T, Takada Y, Kageyama H, Nakamura Y, Hata A, Zhang J-H, Simonds W, Nakagawara A. Koseki H.
    • Journal Title

      Oncogene 24

      Pages: 3385-3396

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390535
  • [Journal Article] Identification of protein kinase A catalytic subunitβ(PKA-Cβ) as a novel binding partner of p73 and regulation of p73 function.2005

    • Author(s)
      Hanamoto, T., Ozaki, T., et al.
    • Journal Title

      J.Biol.Chem. (in press)

    • Data Source
      KAKENHI-PROJECT-15590261
  • [Journal Article] Protein stability and function of p73 are modulated by a physical interaction with RanBPM in mammalian cultured cells.2005

    • Author(s)
      Kramer, S., Ozaki, T., Miyazaki, K., Kato, C., Hanamoto, T., Nakagawara, A.
    • Journal Title

      Oncogene 24

      Pages: 938-944

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590261
  • [Journal Article] Decreased expression of the candidate tumor suppressor gene ING1 is associated with poor prognosis in advanced neuroblastomas.2004

    • Author(s)
      Takahashi M, Ozaki T, Todo S, Nakagawara A.
    • Journal Title

      Oncol.Rep. 12

      Pages: 811-816

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390535
  • [Journal Article] Decreased expression of the candidate tumor suppressor gene ING1 is associated with poor prognosis in advanced neuroblastomas.2004

    • Author(s)
      Takahashi, M., Ozaki, T., et al.
    • Journal Title

      Oncogene 12

      Pages: 811-816

    • Data Source
      KAKENHI-PROJECT-15590261
  • [Journal Article] Polo-like kinase 1(Plk1) inhibits p53 function by physical interaction and phosphorylation.2004

    • Author(s)
      Ando K, Ozaki T, Yamamoto H, Furuya K, Hosoda M, Hayashi S, Fukuzawa M, Nakagawara A.
    • Journal Title

      J.Biol.Chem. 279

      Pages: 25549-25561

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390535
  • [Journal Article] Polo-like Kinase 1(Plk1) inhibits p53 function by physical interaction and phosphorylation.2004

    • Author(s)
      Ando, K., Ozaki, T., et al.
    • Journal Title

      J.Biol.Chem. 279

      Pages: 25519-25561

    • Data Source
      KAKENHI-PROJECT-15590261
  • [Journal Article] NEDL1,a novel ubiquitin-protein isopeptide ligase for Dishevelled-1,targets mutant superoxide dismutase-1.2004

    • Author(s)
      Miyazaki K, Fujita T, Ozaki T, Kato C, Kurose Y, Sakamoto M, Kato S, Goto T, Itoyama Y, Aoki M, Nakagawara A.
    • Journal Title

      J.Biol.Chem. 279

      Pages: 11327-11335

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390535
  • [Journal Article] Low expression of human tubulin tyrosine ligase and suppressed tubulin tyrosination/detyrosination cycle are associated with impaired neuronal differentiation in neuroblastomas with poor prognosis.2004

    • Author(s)
      Kato C, Miyazaki K, Nakagawa A, Ohira M, Nakamura Y, Ozaki T, Imai T, Nakagawara A.
    • Journal Title

      Int.J.Cancer 112

      Pages: 365-375

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390535
  • [Journal Article] Polo-like kinase 1 (Plk1) inhibits p53 function by physical interaction and phosphorylation.2004

    • Author(s)
      Ando, K., Ozaki, T., et al.
    • Journal Title

      J.Biol.Chem. 279

      Pages: 25549-25561

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590261
  • [Journal Article] Polo-like kinase 1(Plk1) inhibits p53 function by physical interaction and phosphorylation.2004

    • Author(s)
      Ando, K., Ozaki, T., Yamamoto, H., Furuya, K., Hosoda, M., Hayashi, S., Fukuzawa, M., Nakagawara, A.
    • Journal Title

      J.Biol.Chem. 279

      Pages: 25549-25561

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590261
  • [Journal Article] Function of p73,not of p53,is inhibited by the physical interaction with RACK1 and its inhibitory effect is counteracted by pRB.2003

    • Author(s)
      Ozaki T, Watanabe K, Nakagawa T, Miyazaki K, Takahashi M, Nakagawara A.
    • Journal Title

      Oncogene 22

      Pages: 3231-3242

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390535
  • [Journal Article] Accumulation of p27^<KIP1> is associated with BMP2-mediated growth arrest and neuronal differentiation of human neuroblastoma-derived cell lines.2003

    • Author(s)
      Nakamura Y, Ozaki T, Koseki H, Nakagawara A, Sakiyama S.
    • Journal Title

      Biochem.Biophys.Res.Commun. 307

      Pages: 206-213

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390535
  • [Journal Article] Negative autoregulation of p73 and p53 by DeltaNp73 in regulating differentiation and survival of human neuroblastoma cells.2003

    • Author(s)
      Nakagawa, T., Ozaki, T., et al.
    • Journal Title

      Cancer Lett. 197

      Pages: 105-109

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590261
  • [Journal Article] Function of p73,not of p53,is inhibited by the physical interaction with RACK1 and its inhibitory effect is counteracted by pRB.2003

    • Author(s)
      Ozaki, T., Watanabe, K., Nakagawa, T., Miyazaki, K., Takahashi, M., Nakagawara, A.
    • Journal Title

      Oncogene 22

      Pages: 3231-3242

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590261
  • [Journal Article] Negative autoregulation of p73 and p53 by ΔNp73 in regulating differentiation and survival of human neuroblastoma cells.2003

    • Author(s)
      Nakagawa T, Takahashi M, Ozaki T, Watanabe K, Hayashi S, Hosoda M, Todo S, Nakagawara A.
    • Journal Title

      Cancer Lett. 197

      Pages: 105-109

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390535
  • [Journal Article] Function of p73, not of p53, is inhibited by the physical interaction with RACK1 and its inhibitory effect is counteracted by pRB.2003

    • Author(s)
      Ozaki, T., Watanabe, K., et al.
    • Journal Title

      Oncogene 22

      Pages: 3231-3242

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590261
  • [Journal Article] Function of p73,not of p53,is inhibited by the physical interaction with RACK1 and its inhibitory effect is counteracted by pRB.2003

    • Author(s)
      Ozaki T, Nakagawara A. et al.
    • Journal Title

      Oncogene 22

      Pages: 3231-3242

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390535
  • [Journal Article] Negative autoregulation of p73 and p53 by DeltaNp73 in regulating differentiation and survival of human neuroblastoma cells.2003

    • Author(s)
      Nakagawa, T., Takahashi, M., Ozaki, T., Watanabe, K., Hayashi, S., Hosoda, M., Todo, S., Nakagawara, A.
    • Journal Title

      Cancer Lett. 197

      Pages: 105-109

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590261
  • [Journal Article] A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity.2003

    • Author(s)
      Miyazaki, K., Ozaki, T., et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 308

      Pages: 106-113

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590261
  • [Journal Article] A novel HECT-type E3 ubiquitin ligase, NEDL2,stabilizes p73 and enhances its transcriptional activity.2003

    • Author(s)
      Miyazaki, K., Ozaki, T., Kato, C., Hanamoto, T., Fujita, T., Irino, S., Watanabe, K., Nakagawa, T., Nakagawara, A.
    • Journal Title

      Biochem.Biophys.Res.Commun. 308

      Pages: 106-113

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590261
  • [Journal Article] UbcH10 is the cancer-related E2 ubiquitin conjugating enzyme.2003

    • Author(s)
      Okamoto Y, Ozaki T, Miyazaki K, Aoyama M, Miyazaki M, Nakagawara A.
    • Journal Title

      Cancer Res. 63

      Pages: 4167-4173

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390535
  • [Journal Article] A novel HECT-type E3 ubiquitin ligase, NEDL2,stabilizes p73 and enhances its transcriptional activity.2003

    • Author(s)
      Miyazaki K, Ozaki T, Kato C, Hanamoto T, Fujita T, Irino S, Watanabe K, Nakagawa T, Nakagawara A.
    • Journal Title

      Biochem.Biophys.Res.Commun. 308

      Pages: 106-113

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390535
  • [Journal Article] Functional implication of p73 protein stability in neuronal cell survival and death

    • Author(s)
      Ozaki T., Nakagawara A., et al.
    • Journal Title

      Cancer Lett (in press)

    • Data Source
      KAKENHI-PROJECT-16021263
  • [Journal Article] Functional implication of p73 protein stability in neuronal cell survival and death.

    • Author(s)
      Ozaki T, Hosoda M, Miyazaki K, Hayashi S, Watanabe K, Nakagawa T, Nakagawara A.
    • Journal Title

      Cancer Lett. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390535
  • [Journal Article] UFD2a mediates the proteasomal turnover of p73 without promoting p73 ubiquitination.

    • Author(s)
      Hosoda M, Ozaki T, Miyazaki K, Hayashi S, Furuya K, Watanabe K, Nakagawa T, Hanamoto T, Todo S, Nakagawara A.
    • Journal Title

      Oncogene (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390535
  • [Journal Article] Functional implication of p73 protein stability in neuronal cell survival and death.

    • Author(s)
      Ozaki T, Nakagawara A. et al.
    • Journal Title

      Cancer Lett (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390535
  • [Presentation] Internalization of DNA minor groove binder pyrrole-imidazole polyamide into cancer cells via active transport machineries2017

    • Author(s)
      下里 修、尾崎俊文
    • Organizer
      International symposium for the drug-discovery of the pyrrole-imidazole polyamides as novel biomedicines
    • Place of Presentation
      日本大学桜門会館
    • Year and Date
      2017-02-24
    • Data Source
      KAKENHI-PROJECT-16K10559
  • [Presentation] スフェア培養を用いたがん幹細胞が有する悪性形質獲得機構の解明2017

    • Author(s)
      下里 修、早田浩明、尾崎俊文
    • Organizer
      第16回日本再生医療学会総会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2017-03-07
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K10559
  • [Presentation] DNA副溝結合性化合物pyrrole-imidazole polyamideの能動輸送を介したがん細胞内移行メカニズム2017

    • Author(s)
      森祐輔、下里修、早田浩明、内海京寛、井上貴博、篠崎喜脩、渡部隆義、永瀬浩喜、尾崎俊文
    • Organizer
      第26回日本癌病態治療研究会
    • Data Source
      KAKENHI-PROJECT-16K10559
  • [Presentation] The hydrophobicity influences the pharmacokinetic property of a DNA minor-grove binder PIP in vivo.2017

    • Author(s)
      T. Inoue, O. Shimozato, N. Matsuo, Y. Shinozaki, T. Watanabe, A. Takatori, N. Koshikawa, T. Ozaki, H. Nagase
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16K10559
  • [Presentation] スフェア培養を用いたがん幹細胞が有する悪性形質獲得機構の解明2017

    • Author(s)
      下里修、早田浩明、松下雅司、内海京寛、森祐輔、筆宝義隆、永瀬浩喜、尾崎俊文
    • Organizer
      第16回日本再生医療学会総会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-15K08412
  • [Presentation] Lipophilicity is a critical determinant essential for the efficient incorporation of pyrrole-imidazole polyamides into malignant tumor tissues2017

    • Author(s)
      井上貴博、下里 修、尾崎俊文
    • Organizer
      International symposium for the drug-discovery of the pyrrole-imidazole polyamides as novel biomedicines
    • Place of Presentation
      日本大学桜門会館
    • Year and Date
      2017-02-24
    • Data Source
      KAKENHI-PROJECT-16K10559
  • [Presentation] スフェア形成能を有する大腸がん細胞のエピゲノム的薬剤耐性機構の解析2016

    • Author(s)
      内海京寛、下里 修、早田浩明、尾崎俊文
    • Organizer
      第25回日本病態治療研究会
    • Place of Presentation
      三井ガーデンホテル千葉
    • Year and Date
      2016-06-08
    • Data Source
      KAKENHI-PROJECT-16K10559
  • [Presentation] Internalization of DNA minor groove binder pyrrole-imidazole polyamide into cancer cells via actin-dependent mechanism.2016

    • Author(s)
      O. Shimozato, M. Matsushita, K. Uchiumi, M. Nakamura, T. Ogata, M. Sang, T. Inoue, T. Watanabe, H. Nagase, T. Ozaki:
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-15K08412
  • [Presentation] Comprehensive genetic analysis for the anticancer activity of a novel alkylating agent targeting KRAS mutation.2016

    • Author(s)
      K. Hiraoka, J. Lin, A. Takatori, A. Hattori, T. Inoue, H. Yoda, S. Krishnamurthy, Y. Shinozaki, T. Watanabe, N. Koshikawa, T. Ozaki, H. Nagase
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-15K08412
  • [Presentation] PTPRKによるがん幹細胞マーカーCD133の脱リン酸化を介した大腸がん進展の抑制2016

    • Author(s)
      松下雅司、下里修、早田浩明、内海京寛、森祐輔、中村瑞代、小形武広、桑梅潔、尾崎俊文
    • Organizer
      第25回日本病態治療研究会
    • Place of Presentation
      千葉
    • Data Source
      KAKENHI-PROJECT-15K08412
  • [Presentation] RUNX2 depletion improves gemcitabine sensitivity of p53-mutated pancreatic cancer cells through stimulation of TAp73.2016

    • Author(s)
      M. Nakamura, H. Sugimoto, T. Ogata, M. Sang, O. Shimozato, T. Ozaki
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-15K08412
  • [Presentation] Internalization of DNA minor groove binder pyrrole-imidazole polyamide into cancer cells via actin-dependent mechanism2016

    • Author(s)
      下里 修、早田浩明、尾崎俊文
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-08
    • Data Source
      KAKENHI-PROJECT-16K10559
  • [Presentation] Analysis of the role of GASC1 in development of skin tumor2016

    • Author(s)
      藤原恭子、尾崎由美、照井正、永瀬浩喜、相馬正義
    • Organizer
      第9回 日本大学先端バイオフォーラム
    • Place of Presentation
      日本大学会館(東京都、千代田区)
    • Year and Date
      2016-01-27
    • Data Source
      KAKENHI-PROJECT-15K09791
  • [Presentation] NLRR2 is involved in neuronal survival and differentiation through JNK pathway in neuroblastoma2015

    • Author(s)
      Afzal Sheikh,Atsushi Takatori,Md.Shamim Hossain,Md.Kamrul Hasan,Toshinori Ozaki ,Hiroki Nagase,Masatoshi Tagawa,Akira Nakagawara
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-15K08412
  • [Presentation] 進行神経芽腫に対するMYCN遺伝子標的ピロールイミダゾールポリアミドDNAアルキル化剤複合体の開発2015

    • Author(s)
      養田裕行、高取敦志、井上貴博、渡部隆義、越川信子、尾崎俊文、永瀬浩喜
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-10
    • Data Source
      KAKENHI-PROJECT-15K08412
  • [Presentation] RUNX2の発現抑制を介したTAp63の活性化による膵臓がん細胞のゲムシタビン感受性の向上2015

    • Author(s)
      中村瑞代、杉本博一、小形武広、下里修、永瀬浩喜、尾崎俊文
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-10
    • Data Source
      KAKENHI-PROJECT-15K08412
  • [Presentation] 新規アルキル化剤: ピロールイミダゾールポリアミド複合体による変異型 KRAS の発現抑制2015

    • Author(s)
      平岡桐子、井上貴博、養田裕行、クリシュナムルティサクティスリ、ジェイソンリン、渡部隆義、越川信子、高取敦志、尾崎俊文、永瀬浩喜
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-15K08412
  • [Presentation] KR12, KRAS mutation specific alkylating agent inhibits tumor growth by showing accumulation in KRAS mutant xenografts2015

    • Author(s)
      Takahiro Inoue,Kiriko Hiraoka,Hiroyuki Yoda,Takayoshi Watanabe,Atsushi Takatori,Nobuko Koshikawa,Toshikazu Bando,Hiroshi Sugiyama,Toshinori Ozaki, Hiroki Nagase
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-15K08412
  • [Presentation] RUNX2 inhibits p53-dependent apoptosis following DNA damage in collaboration with HDAC62013

    • Author(s)
      Ozaki T, Sugimoto H, Nakagawara A, Nagase H
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2013-10-04
    • Data Source
      KAKENHI-PROJECT-23501278
  • [Presentation] Phosphorylation of NFBD1/MDC1 by plk1 regulates decatenation checkpoint-mediated G2/M transition2013

    • Author(s)
      Ando K, Ozaki T, Hirota T, Nakagawara A
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2013-10-04
    • Data Source
      KAKENHI-PROJECT-23501278
  • [Presentation] DNA 損傷に応答したアポトーシス誘導過程における複合体形成を介した RUNX1 による p53 の制御機構の解析2012

    • Author(s)
      呉丹、久保奈津美、尾崎俊文、中川原章
    • Organizer
      第 71 回日本癌学会総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23501278
  • [Presentation] DNA 損傷応答過程におけるp53 と RUNX2 との機能的相互作用の解析2012

    • Author(s)
      尾崎俊文 呉丹、久保奈津美、上條岳彦、中川原章
    • Organizer
      第 71 回日本癌学会総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23501278
  • [Presentation] p53依存性アポトーシス誘導過程におけるRUNX2の役割2011

    • Author(s)
      久保奈津美、呉丹、中川原章、上條岳彦、尾崎俊文
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-23501278
  • [Presentation] DNA損傷に応答したRUNX1によるp53の活性化機構の解析2011

    • Author(s)
      呉丹、久保奈津美、吉原由佳里、尾崎俊文、中川原章
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23501278
  • [Presentation] Transcriptional regulation of NFBD1/MCC1 in response to DNA damage2008

    • Author(s)
      Ozaki, et. al.
    • Organizer
      66th Annual meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-10-03
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590279
  • [Presentation] DNA損傷に応答したNFBD1/MDC1遺伝子の発現調節機構の解析2007

    • Author(s)
      尾崎 俊文
    • Organizer
      第66回日本癌学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-10-03
    • Data Source
      KAKENHI-PROJECT-18590279
  • [Presentation] Phosphorylation of NFBD1/MDC1 by plk1 regulates decatenation checkpoint-mediated G2/M transition

    • Author(s)
      Ando K, Ozaki T, Hirota T, Nakagawara A.
    • Organizer
      日本癌学会
    • Place of Presentation
      YOKOHAMA
    • Data Source
      KAKENHI-PROJECT-23501278
  • [Presentation] RUNX2 inhibits p53-dependent apoptosis following DNA damage in collaboration with HDAC6

    • Author(s)
      Ozaki T, Sugimoto H, Nakagawara A, Nagase H.
    • Organizer
      日本癌学会
    • Place of Presentation
      YOKOHAMA
    • Data Source
      KAKENHI-PROJECT-23501278
  • 1.  NAKAGAWA Akira (50117181)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 30 results
  • 2.  ICHIKAWA Miki (20311384)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 4 results
  • 3.  FUJIWARA Kyoko (40595708)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 4.  崎山 樹 (30260243)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  NAKAMURA Yuko (60260254)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  NAGASE Hiroki (90322073)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 12 results
  • 7.  KAGEYAMA Hajume (50260253)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  ISOGAI Eriko (40300917)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  MURATA Motoi (90260257)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  TAKENOBU Hisanori (60392247)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  SHIMOZATO OSAMU (30344063)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 10 results
  • 12.  TAKAGI Keiko (20339328)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  近藤 和博 (60221983)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  大羽 成征 (80362838)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  田川 雅敏 (20171572)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  早田 浩明 (90261940)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 17.  緑川 泰 (10292905)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  照井 正 (30172109)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 19.  TATSUMI Yasutoshi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 20.  Tatsumi Koichiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 21.  Matsumura Takuma
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 22.  NAKAMURA Toshinobu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 23.  WATANABE Takayoshi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 24.  伊川 正人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 25.  篠原 隆司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 26.  二階堂 敏雄
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 27.  古関 明彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 28.  日和佐 隆樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  寺田 二郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 30.  松尾 英将
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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