ITO Daisuke 伊東大典

Researcher Number	40286844
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2010: Tokyo Medical and Dental University, その他 2010: 東京医科歯科大学, 大学院・医歯学総合研究科, 非常勤講師 2008 – 2010: Tokyo Medical and Dental University, 硬組織疾患ゲノムセンター, 特任講師 2008: 東京医科歯科大学, 歯学部, 特任講師 2008: 東京医科歯科大学, 歯学部, 講師 … More
Review Section/Research Field	Principal Investigator Surgical dentistry / Surgical dentistry Except Principal Investigator Surgical dentistry / Surgical dentistry
Keywords	Principal Investigator 遺伝子治療 / NK細胞 / マウス / B16F10 / 3LL / IL-12 / プラスミドベクター / 悪性腫瘍 / 化学発癌モデル / 細胞周期 … More Except Principal Investigator 口腔癌 / p21 / 細胞周期 / p53 / 4NQO / 遺伝子導入 / マウス / 発癌剤 / 上皮異形成 / 口腔扁平上皮癌 / 遺伝子診断・治療 / 口腔白板症 / MDM2 / 癌化 / 舌粘膜上皮 / oral leukoplakia / VEGFR-3 / HGF / c-Met / 遺伝子欠失マウス / 口腔粘膜上皮 / c-myc / c-fos / G1期 / COX-2阻害剤 / NS-398 / 舌癌由来扁平上皮癌細胞 / 白血病細胞 / 増殖抑制 / プロスタグランディン / PD-1遺伝子 / SCC抗原作動型 / 免疫遺伝子療法 / 口腔癌モデル / マウス舌粘膜 / 4-NQO / 臨床腫瘍学 / 分子標的治療 / アポトーシス / デスレセプター / 癌 / 遺伝子 / シグナル伝達 / 発現抑制 / 唾液 / 腫瘍マーカー / 唾液タンパク / 新規腫瘍マーカー / 病理組織 / 診断 / センチネルリンパ節 / 免疫応答 / 微少転移 / 悪性腫瘍 / 転移 / 腫瘍間質組織 / 口腔癌における発症機序 / 口腔癌発癌予測システム / 口腔癌の発症メカニズム / テロメラーゼ / ウイルス治療 / テロメライシン / テロメスキャン / ウィルス性剤 / 癌の可視化 / 口腔外科一般 / 口腔粘膜疾患 / 免疫抑制分子 / 上皮角化細胞 / 免疫療法 / インターフェロン-γ / インターロイキン12 / interferon-gamma / oral cancer / interleukin-12 / p53遺伝子欠失マウス / 野生型マウス / 発癌物質 / p53非依存性経路 / ATM / Rb / E2F / P53 deficient mouse / wild type mouse / carcinogen / P53 / p53 independent pathway / 上皮性異形成 / 遺伝子発現プロファイル / カリクレイン遺伝子 / サイトケラチン遺伝子 / 癌化予測マーカー / DNAチップ / 免疫染色 / 遺伝子プロファイル / マウス口腔粘膜 / 遺伝子発プロファイル / 前癌病変 / ヒト白板症 / mouse / epithelial dysplasia / gene expression profile / malignant transformation / kallikrein / cytokeratin / marker of malignant transformation / 扁平上皮癌 / VEGF / SCC抗原 / HIF1-α / HIF-1α / VFGF / LYMPHANGIOGENESIS / HIF / SQUAMOUS CELL CARCINOMA / MMP Less

Telomerase-Specific Replication-Selective Virotherapy for oral squamous cell carcinoma cell lines
- Principal Investigator
  
  SHINTANI Satoru
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Showa University
The analysis of the immune-inhibitory molecules in refractory inflammatory oral mucous disease and the basic research for development of new therapy.
- Principal Investigator
  
  TSUSHIMA Fumihiko
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Tokyo Medical and Dental University
TGF阻害と新規癌抗原を組み合わせた強化型口腔癌樹状細胞療法開発のための研究Principal Investigator
- Principal Investigator
  
  伊東大典
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Tokyo Medical and Dental University
Study of apoptotic induction through siRNA of c-FLIP in squamous cell carcinoma cells
- Principal Investigator
  
  IWASE Masayasu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Showa University
唾液より検出される新規腫瘍マーカーの機能解析による口腔癌の新しい診断法の確立
- Principal Investigator
  
  MATUURA Mituhiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Showa University
免疫応答をマーカーとしたセンチネルリンパ節微少転移診断
- Principal Investigator
  
  OOHASHI Masaru
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Showa University
Occurrence mechanism of oral leukoplakia and squamous cell carcinoma examining from abnormality of stromal tissue
- Principal Investigator
  
  TOYOSHIMA Takahiko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Showa University
Research on a highly-efficient and tumor-specific gene therapy using autologous NK/NKT cells as gene carriersPrincipal Investigator
- Principal Investigator
  
  ITO Daisuke
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Showa University
遺伝子治療と組織再生技術を組み合わせたシェーグレン症候群の治療と唾液腺機能回復Principal Investigator
- Principal Investigator
  
  伊東大典
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Showa University
ESTABLISHMENT OF ANTI-LYMPHANGIOGENETIC THERAPY BY CANCER SPECIFIC s-VEGFR-3.
- Principal Investigator
  
  HATORI Masashi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  SHOWA UNIVERSITY
SCC抗原作動型PD-1-Ig遺伝子を応用した新たな口腔癌免疫遺伝子療法の試み
- Principal Investigator
  
  南雲正男
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Surgical dentistry
- Research Institution
  Showa University
Prediction of malignant transformation of oral precancerous lesions by analyzing gene expression profiles and gene polymorphism.
- Principal Investigator
  
  NAGUMO Masao
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Surgical dentistry
- Research Institution
  Showa University
マウス化学発癌モデルを応用した口腔粘膜前癌病変の癌化予防遺伝子療法に関する研究Principal Investigator
- Principal Investigator
  
  伊東大典
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Showa University
The participation of p53 independent pathway in the process of oral carcinogenesis
- Principal Investigator
  
  NAGUMO Masao
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Showa University
条件的遺伝子発現機構を応用した抗腫瘍IL-12遺伝子療法の研究Principal Investigator
- Principal Investigator
  
  伊東大典
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Surgical dentistry
- Research Institution
  Showa University
COX-2阻害剤による口腔癌の増殖抑制とその機序の解明
- Principal Investigator
  
  南雲正男
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Surgical dentistry
- Research Institution
  Showa University
導入遺伝子の選択的発現調節による抗悪性腫瘍遺伝子療法の新たな試みPrincipal Investigator
- Principal Investigator
  
  伊東大典
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Showa University
p53遺伝子欠失マウスを用いた口腔癌発症機序の解析
- Principal Investigator
  
  NAGUMO Masao
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Surgical dentistry
- Research Institution
  Showa University
Establishment of therapeutic methods against oral cancer using interferon-gamma gene
- Principal Investigator
  
  KAMIJO Ryutaro
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Showa University

All 2009 2008 2007 2006 2004 Other

All Journal Article Presentation

[Journal Article] 口腔扁平苔癬135例の臨床的検討2009
- Author(s)
  伊東大典, 他
- Journal Title
  
  日本口腔粘膜学会雑誌 15
  
  Pages: 22-28
- NAID
  10026398178
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592365
[Journal Article] Enhanced susceptibility to apoptosis of oral squamous cell carcinoma cells subjected to combined treatment with anticancer drugs and phosphatidylinositol 3-kinase inhibitors2007
- Author(s)
  Iwase M, Yoshiba S, Uchida M, Takaoka S, Kurihara Y, Ito D, Hatori M, Shintani S
- Journal Title
  
  Int J Oncol 31
  
  Pages: 1141-1147
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390524
[Journal Article] Changes in the expression of transglutaminase-3 in the chemically-induced oral epithelial dysplasia2006
- Author(s)
  Ito, D, et. al.
- Journal Title
  
  J Jpn Assoc Oral Muc Membr 12(2)
  
  Pages: 51-58
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18592200
[Journal Article] Gene expression profiles of oral leukoplakia and carcinoma:A genome-wide comparison analysis using an oligonucleotide microarray technology2006
- Author(s)
  Odani T, Ito D, et. al.
- Journal Title
  
  International Journal of Oncology 28
  
  Pages: 619-624
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18592200
[Journal Article] Thalidomide suppresses melanoma growth by activating NK cells in mice2006
- Author(s)
  Kawamata A, Ito D, et. al.
- Journal Title
  
  Oncology Reports 16
  
  Pages: 1231-1236
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18592200
[Journal Article] 化学誘発性マウスロ腔粘膜上皮性異形成におけるtransglutaminase-3の発現変化2006
- Author(s)
  伊東大典、磯辺友秀, 他
- Journal Title
  
  日本口腔粘膜学会雑誌 12(2)
  
  Pages: 51-58
- NAID
  130003449484
- Data Source
  KAKENHI-PROJECT-18592200
[Journal Article] Gene expression profiles of oral leukoplakia and carcinoma : Genome-wide comparison analysis using oligonucleotide microarray technology.2006
- Author(s)
  Odani T, Ito D, Li M-H, et al.
- Journal Title
  
  International Journal of Oncology 28(3)
  
  Pages: 619-624
- Data Source
  KAKENHI-PROJECT-16791256
[Journal Article] Gene expression profiles of oral leukoplakia and carcinoma : A genome-wide comparison analysis using an oligonucleotide microarray technology2006
- Author(s)
  Odani, T, Ito, D, et. al.
- Journal Title
  
  Int J Oncol 28
  
  Pages: 619-624
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18592200
[Journal Article] Gene expression profiles of oral leukoplakia and carcinoma : A genome-wide comparison analysis using an oligonucleotide microarray technology2006
- Author(s)
  Odani T, Ito D, et al.
- Journal Title
  
  International Journal of Oncology 28
  
  Pages: 619-624
- Data Source
  KAKENHI-PROJECT-18592200
[Journal Article] Thalidomide suppresses melanoma growth by activating NK cells in mice2006
- Author(s)
  Kawamata A, Ito D, et al.
- Journal Title
  
  Oncology Reports 16
  
  Pages: 1231-1236
- Data Source
  KAKENHI-PROJECT-18592200
[Journal Article] 化学誘発性マウス口腔粘膜上皮性異形成におけるtransglutaminase-3の発現変化2006
- Author(s)
  伊東大典, 磯辺友秀, 他
- Journal Title
  
  日本口腔粘膜学会雑誌 12(2)
  
  Pages: 51-58
- NAID
  10018827774
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18592200
[Journal Article] A case of bullous pemphigoid initially occurred in the oral cavity2006
- Author(s)
  Ito, D, et. al.
- Journal Title
  
  J Jpn Assoc Oral Muc Membr 12(1)
  
  Pages: 30-35
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18592200
[Journal Article] Gene expression proilles or oral reukopiakia and carcinoma. A genome-wide comparison analysis using an oligonucleotide microarray2006
- Author(s)
  Odani T, Ito D, et. al.
- Journal Title
  
  International Journal of Oncology 28
  
  Pages: 619-624
- Data Source
  KAKENHI-PROJECT-18592200
[Journal Article] Thalidomide suppresses melanoma growth by activating natural killer cells in mice2006
- Author(s)
  Kawamata, A, Ito, D, et. al.
- Journal Title
  
  Oncol Rep 16
  
  Pages: 1231-1236
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18592200
[Journal Article] 化学誘発性マウス口腔粘膜上皮性異形成におけるtransglutaminase-3の発現変化2006
- Author(s)
  伊東大典, 磯辺友秀, 他
- Journal Title
  
  日本口腔粘膜学会雑誌 12(2)
  
  Pages: 51-58
- NAID
  10018827774
- Data Source
  KAKENHI-PROJECT-18592200
[Journal Article] 口腔内に初発した水疱性類天疱瘡の1例2006
- Author(s)
  伊東大典, 豊田華, 他
- Journal Title
  
  日本口腔粘膜学会雑誌 12(1)
  
  Pages: 30-35
- NAID
  10018827927
- Data Source
  KAKENHI-PROJECT-18592200
[Journal Article] Effect of 5-fluorouracil on G1 phase cell cycle regulation in oral cancer cell lines.2004
- Author(s)
  Li M-H, Ito D, Sanada M, Odani T, Hatori M, Iwase M, Nagumo M
- Journal Title
  
  Oral Oncol. 40
  
  Pages: 63-70
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16592020
[Journal Article] Effect of 5-fluorouracil on G1 phase cell cycle regulation in oral cancer cell lines.2004
- Author(s)
  Li M-H, Ito D, Sanada M, et al.
- Journal Title
  
  Oral Oncology 40(1)
  
  Pages: 63-70
- Data Source
  KAKENHI-PROJECT-16791256
[Journal Article] Inhibition of cyclooxygenase-2 suppresses invasiveness of oral squamous cell carcinoma cell lines via down-regulaion of matrix metalloproteinase-2 and CD44.2004
- Author(s)
  Kinugasa Y, Hatori M, Ito H, Kurihara Y, Ito D, Masao Nagumo
- Journal Title
  
  Clin Exp Metastasis 21
  
  Pages: 737-745
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16592020
[Journal Article] Inhibition of cyclooxygenase-2 suppresses invasiveness of oral squamous cell carcinoma cell lines via down-regulation of matrix metalloproteinase-2 and CD44.2004
- Author(s)
  Kinugasa Y, Hatori M, Ito H, Kurihara Y, Ito D, Masao Nagumo
- Journal Title
  
  Clinical and Experimental Metastasis 21
  
  Pages: 737-745
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16592020
[Journal Article] Effect of 5-fluorouracil on G1 phase cell cycle regulation in oral cancer cell lines.2004
- Author(s)
  Li M-H, Ito D, Sanada M, Odani T, Hatori M, Iwase M, Nagumo M
- Journal Title
  
  Oral Oncology 40
  
  Pages: 63-70
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16592020
[Journal Article] Hypoxia induces resistance to 5-fluorouracil in oral cancer cells via G1 phase cell cycle arrest
- Author(s)
  Yoshiba, S, Ito, D, et. al.
- Journal Title
  
  Oral Oncology (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18592200
[Journal Article] Hypoxia induces resistance to 5-FU in oral cancer cells via G1 phase cell cycle arrest
- Author(s)
  Yoshiba S, Ito D, et. al.
- Journal Title
  
  Oral Oncology (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592312
[Journal Article] Thalidomide suppresses melanoma growth by activating natural killer cells in mice.
- Author(s)
  Kawamata A, Odani T, Isobe T, Iwase M, Hatori M, Nagumo M, Ito D
- Journal Title
  
  Journal of immunology (in submission)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16592020
[Journal Article] Alterations in G1 phase cell cycle regulation during the development of benzo[a]pyrene-induced epithelial dysplasia in the murine tongue
- Author(s)
  Ota-Sanada M, Ito D, Li M-H, et al.
- Journal Title
  
  Oral Science International In press
- NAID
  10017396497
- Data Source
  KAKENHI-PROJECT-16791256
[Journal Article] Thalidomide suppresses melanoma growth by activating natural killer cells in mice.
- Author(s)
  Kawamata A, Odani T, Isobe T, Iwase M, Hatori M, Nagumo M, Ito D
- Journal Title
  
  J Immnol. In submission
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16592020
[Journal Article] Selective COX-2 inhibition suppresses invasiveness of oral squamous cell carcinoma cells through down-regulation of MMP-9.
- Author(s)
  Saito M et al.
- Journal Title
  
  J Showa Univ Dent Socie (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209070
[Presentation] 口腔扁平苔癬135例の臨床的検討2009
- Author(s)
  伊東大典, 他
- Organizer
  第18回日本口腔粘膜学会総会・学術集会
- Place of Presentation
  神奈川県葉山町
- Year and Date
  2009-06-06
- Data Source
  KAKENHI-PROJECT-20592365
[Presentation] Hypoxia induces resistance to 5-FU in oral cancer cells via G1 phase cell cycle arrest2008
- Author(s)
  Yoshiba S, Ito D, et. al.
- Organizer
  Annual Meeting of the AACR
- Place of Presentation
  San Diego,USA
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18592200
[Presentation] Hypoxia induces resistance to 5-FU in oral cancer cells via Gl phase cell cycle arrest2008
- Author(s)
  Yoshiba S, Ito D, et. al.
- Organizer
  Annual Meeting of the AACR
- Place of Presentation
  アメリカ、サンディエゴ
- Data Source
  KAKENHI-PROJECT-18592200
[Presentation] Hypoxia induces resistance to 5-fluorouracil in oral cancer cells via G1 phas cell cycle arrest2008
- Author(s)
  Yoshiba, S, Ito, D, et. al.
- Organizer
  Annual Meeting of AACR
- Place of Presentation
  San Diego
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18592200
[Presentation] European Association for Cranio2008
- Author(s)
  Saliva tumor markers for the identification of oral cancer S. Shintani, M. Hatori, T. Toyoshima, Y. Kurihara, Y. Kurokawa, H. Nakahira, T. Ito, T. Shirota
- Organizer
  Maxillofacial Surgery 9th-12th
- Place of Presentation
  Bologna, Italy
- Data Source
  KAKENHI-PROJECT-19592312

1. NAGUMO Masao (70013993)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. IWASE Masayasu (50193743)

# of Collaborated Projects: 5 results

# of Collaborated Products: 1 results
3. SHINTANI Satoru (80294429)

# of Collaborated Projects: 5 results

# of Collaborated Products: 2 results
4. HATORI Masashi (20245814)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
5. KAMIJO Ryutaro (70233939)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. ITO Hidetoshi (80384303)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. MATUURA Mituhiro (00297037)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. OOHASHI Masaru (40317524)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TOYOSHIMA Takahiko (90338533)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. TSUSHIMA Fumihiko (90456210)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. AZUMA Miyuki (90255654)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SAKURAI Jinkyo (30361710)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. ODANI Takeshi (40407440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
14. 堀雅人 (10276602)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

ITO Daisuke 伊東 大典

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Research Products

Co-Researchers

Principal Investigator

Project Period (FY)

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TGF阻害と新規癌抗原を組み合わせた強化型口腔癌樹状細胞療法開発のための研究Principal Investigator

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Research on a highly-efficient and tumor-specific gene therapy using autologous NK/NKT cells as gene carriersPrincipal Investigator

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遺伝子治療と組織再生技術を組み合わせたシェーグレン症候群の治療と唾液腺機能回復Principal Investigator

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マウス化学発癌モデルを応用した口腔粘膜前癌病変の癌化予防遺伝子療法に関する研究Principal Investigator

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条件的遺伝子発現機構を応用した抗腫瘍IL-12遺伝子療法の研究Principal Investigator

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ITO Daisuke 伊東大典