IWASE Masayasu 岩瀬正泰

Researcher Number	50193743
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2011: 鶴見大学, 歯学部, 非常勤講師 2010: 昭和大学, 歯学部, 兼任講師 1992 – 2009: 昭和大学, 歯学部, 講師 2000: 昭和大, 歯学部, 講師 1990: Showa University, Dental School, Assistant Prof., 歯学部, 講師
Review Section/Research Field	Principal Investigator Surgical dentistry / Surgical dentistry Except Principal Investigator Surgical dentistry / Surgical dentistry / 矯正・小児・社会系歯学 / 外科・放射線系歯学
Keywords	Principal Investigator アポトーシス / 好中球 / Fas / Apoptosis / サイトカイン / 接着分子 / FLIP / Neutrophil / 走化性因子 / 急性炎症 … More / Chemoattractant / Fas抗原 / デスレセプター / 分子標的治療 / 臨床腫瘍学 / NSAID / CHEMOKINE / CYTOKINE / ADOHESIVEMOLECULE / ENDOTHELIAL CELLS / NEUTROPHILS / FAS / APOPTOSIS / NSAIDs / ケモカイン / 血管内皮細胞 / 末梢血好中球 / Adhesion molecule / Chemotactic factor / Glutathione / Caspase / 細胞接着分子 / グルタチオン / カスパーゼ / Cytokine / Differentiotion / Auute inflammation / Fas ligand / Fas antigen / 活性酸素 / 感染症 / 分化 / Fasリガンド / as antigen / Bacterial material / Inflammation / Cytokaine / Neutrophils / 細菌産物 / 化学老化性物質 / 細胞産物 / 科学走化性物質 / 炎症 / インターフェロン / OK432 / 抗腫瘍効果 / TRAIL / 発現抑制 / シグナル伝達 / 遺伝子 / 癌 / 中性プロテアーゼ / 付着能 / ロイコトキシン / Actinobacillus actinomycetemcomitans / 線維芽細胞 … More Except Principal Investigator 癌化 / p21 / oral leukoplakia / apoptosis / アポトーシス / 口腔癌 / 3LL / B16F10 / mouse / マウス / 舌粘膜上皮 / MDM2 / 口腔白板症 / MMP / CD44 / PT-PCR / Fas L / Fas / ICAM-1 / 5-Fu / CDDP / 細胞周期 / epithelial dysplasia / P53 / SNP / Tunel法 / 上皮異形成 / 白板症 / carcinogenesis / 癌遺伝子 / TGF-alpha / c-myc / 前癌病変 / superoxide dismutase / P16INK4 / tumor transplantation model / NK cells / p161NK4 / p16INK4 / 移植腫瘍モデル / NK細胞 / marker of malignant transformation / cytokeratin / kallikrein / malignant transformation / gene expression profile / ヒト白板症 / 遺伝子発プロファイル / マウス口腔粘膜 / 発癌剤 / 遺伝子プロファイル / 免疫染色 / DNAチップ / 癌化予測マーカー / サイトケラチン遺伝子 / カリクレイン遺伝子 / 遺伝子発現プロファイル / 上皮性異形成 / Arch length and width / Three dimensional study model analysis / Growth control / Bone morphometry / Soft X-way / Bone labelling / Titanium mini-screw / Adolescent male Beagle dog / 歯列弓長径 / 歯列弓径 / 3次元模型計測 / 成長の抑制 / 骨形態計測 / 軟X線写真 / 骨標識 / チタン製ミニスクリュー / 雄性ビーグル幼犬 / bone formation and maturation / relapse / low intensity pulsed ultrasound / rapid palatal expansion / ラベリング / 新生骨形成 / 口蓋縫合部 / 保定 / あと戻り / 骨成熟 / 低出力超音波パルス / 歯の後戻り / 骨形成 / 骨ラベリング剤 / 低出力超音波照射 / 上顎急速拡大 / ビーグル幼若犬 / p53 independent pathway / carcinogen / wild type mouse / P53 deficient mouse / E2F / Rb / 4NQO / ATM / p53非依存性経路 / p53 / 発癌物質 / 野生型マウス / p53遺伝子欠失マウス / Cytokeratin 19 / circulating cancer cell / magnetic bead / metastasis / oral cancer / mRNA / RT-PCR / 末梢血中細胞 / 局平上皮癌 / サイトケラチン19 / 末稍血中癌細胞 / 磁気ビーズ / 転移 / TNF-alpha / caspase / NO donors / IFN-γ / 可溶性Fas / FasL / 5-FU / TNF-α / カスペース / NO供与体 / TUNEL method / p53 knockout mouse / waf1 / cell cycle / cycline dependent kinase / G1 cycline / サイクリン / P53遺伝子欠失マウス / TUNEL法 / Waf1 / P21 / サイクリン依存性キナーゼ / G1サイクリン / oncogene / P53 protein / Le^y antigen / leukoplakia / bcl-2 / 異形成 / 遺伝子 / 抗癌剤 / Le^y抗原 / TGF-α / P53蛋白 / Le^Y抗原 / cell proliferation / Langerhans cell / gene expression / cytokines / precancerous lesions / myc / ras / IFN-gamma / HLA-DR抗原 / ウンゲルハンス細胞 / 細胞増殖 / ランゲルハンス細胞 / 遺伝子発現 / サイトカイン / bleomycin / superoxide anion / catalase / anticancer drugs / cancer cell line / 口腔癌由来株細胞 / 口腔悪性腫瘍 / ブレオマイシン / ス-パ-オキサイド / カタラ-ゼ / ス-パ-オキサイドディスムタ-ゼ / 抗腫瘍剤 / 腫瘍株細胞 / ウイルス治療 / 口腔扁平上皮癌 / TGF-beta / Smad7 / テロメラーゼ / 遺伝子導入 / 癌特異抗原 / TGFβ / 樹状細胞療法 Less

Antitumor effect of neutrophil-derived TRAIL for oral squamous cell carcinomaPrincipal Investigator
- Principal Investigator
  
  IWASE Masayasu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Tsurumi University
  Showa University
テロメラーゼ作動性Smad7発現型ウイルスによる口腔癌の制御
- Principal Investigator
  
  羽鳥仁志
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Showa University
TGF阻害と新規癌抗原を組み合わせた強化型口腔癌樹状細胞療法開発のための研究
- Principal Investigator
  
  伊東大典
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Tokyo Medical and Dental University
Study of apoptotic induction through siRNA of c-FLIP in squamous cell carcinoma cellsPrincipal Investigator
- Principal Investigator
  
  IWASE Masayasu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Showa University
Research on a highly-efficient and tumor-specific gene therapy using autologous NK/NKT cells as gene carriers
- Principal Investigator
  
  ITO Daisuke
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Showa University
Prediction of malignant transformation of oral precancerous lesions by analyzing gene expression profiles and gene polymorphism.
- Principal Investigator
  
  NAGUMO Masao
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Surgical dentistry
- Research Institution
  Showa University
BASIC APPROACH OF THE IMPLANT ORTHODONTICS FOR THE JUVENILE PATIENTS
- Principal Investigator
  
  SAITO Shigeru
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  矯正・小児・社会系歯学
- Research Institution
  SHOWA UNIVERSITY
The participation of p53 independent pathway in the process of oral carcinogenesis
- Principal Investigator
  
  NAGUMO Masao
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Showa University
EFFECTS OF LOW INTENSITY PULSED ULTRASOUND ON BONE MATURATION IN MANDIBULAR DISTRACTION OSTEOGENESIS AND RAPID PALATAL EXPANSION IN YOUNG DOGS
- Principal Investigator
  
  KURABAYASHI Hitomi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  矯正・小児・社会系歯学
- Research Institution
  SHOWA UNIVERSITY
MECHANISM OF PROLONGED INFLAMMATION IN THE ORAL:EFFECT OF NEUTROPHIL APOPTOSIS ON ENDOTHELIAI CELLSPrincipal Investigator
- Principal Investigator
  
  IWASE Masayasu
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  SHOWA UNIVERSITY
Development of detection method of metastasis from squamous cell carcinoma of head and neck using peripheral blood
- Principal Investigator
  
  NAGUMO Masao
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Surgical dentistry
- Research Institution
  Showa University
Pathogenic mechanism of oral severe infection: Analysis of phagocytic process for apoptotic neutrophilsPrincipal Investigator
- Principal Investigator
  
  IWASE Masayasu
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Showa University
Basic research for oral cancer therapy by anti-cancer drugs and apoptosis-inducing factor
- Principal Investigator
  
  NAGUMO Masao
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Showa University
Cell cycle and apoptosis in the process of carcinogenesis in oral precancerous lesions
- Principal Investigator
  
  NAGUMO Masao
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Showa University
Pothogenic mechanism of oral severe infection : Effect of oxidativc stress on neutrophil apoptosis.Principal Investigator
- Principal Investigator
  
  IWASE Masayasu
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Showa University
Apoptosis in the process of carcinogenesis of oral precancerous lesions
- Principal Investigator
  
  NAGUMO Masao
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Showa University
Control mechanisms on apoptosis of peripheral blood neutrophils, and the relationship for oral infection and oral mucous disease.Principal Investigator
- Principal Investigator
  
  IWASE Masayasu
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Showa University
Actinobacillusロイコトキシンによる組織障害機序の解明Principal Investigator
- Principal Investigator
  
  岩瀬正泰
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Surgical dentistry
- Research Institution
  Showa University
Changes of cytokines and their gene expression in the process of carcinogenesis of oral precancerous lesions
- Principal Investigator
  
  NAGUMO Masao
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  外科・放射線系歯学
- Research Institution
  Showa University
SOD and Catalase Activity in Oral Cancer Cell Line.
- Principal Investigator
  
  SAKURADA Shigeyo
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  外科・放射線系歯学
- Research Institution
  Showa university

All 2011 2009 2008 2007 2006 2003

All Journal Article Presentation

[Journal Article] Protease inhibitor sensitizes oral squamous cell carcinoma cells to TRAIL-mediated apotpsis.2011
- Author(s)
  Yoshiba S, Iwase K, et al
- Journal Title
  
  Oncol Rep
  
  Volume: 25 Pages: 645-652
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592562
[Journal Article] Proteasome inhibitor sensitizes oral squamous cell carcinoma cells to TRAIL-mediated apoptosis2011
- Author(s)
  SAYAKA YOSHIBA, MASAYASU IWASE, SAYAKA TAKAOKA, MAKIKO UCHIDA, YUJI KURIHARA, HITOSGI WATANABE, SATORU SHINTANI
- Journal Title
  
  Oncology Reports
  
  Volume: 25 Pages: 645-652
- Data Source
  KAKENHI-PROJECT-21592562
[Journal Article] Epidermal growth factor receptor inhibitors enhance susceptibility to Fas-mediated apoptosis in oral squamous cell carcinoma cells2008
- Author(s)
  Iwase M, Takaoka S, Uchida M, Yoshiba S, Kondo G, Watanabe H, Ohashi M, Nagumo M
- Journal Title
  
  Oral Oncol 44
  
  Pages: 361-368
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390524
[Journal Article] Epidermal growth factor receptor inhibitors enhance susceptibility to Fasmediated apoptosis in oral squamous cell carcinoma cells.2008
- Author(s)
  Iwase M, et al
- Journal Title
  
  Oral Oncol 44
  
  Pages: 361-368
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390524
[Journal Article] Enhanced susceptibility to apoptosis of oral squamous cell carcinoma cells subjected to combined treatment with anticancer drugs and phosphatidylinositol 3-kinase inhibitors2007
- Author(s)
  Iwase M, Yoshiba S, Uchida M, Takaoka S, Kurihara Y, Ito D, Hatori M, Shintani S
- Journal Title
  
  Int J Oncol 31
  
  Pages: 1141-1147
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390524
[Journal Article] Enhanced susceptibility of apoptosis of oral squamous cell carcinoma cells subjected to combined treatment with anticancer drugs and phosphatidylinositol 3-kinase inhibitors2007
- Author(s)
  Iwase, M, et. al.
- Journal Title
  
  Int J Oncol 31(5)
  
  Pages: 1141-1147
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18592200
[Journal Article] Enhanced susceptibility to tumor necrosis factor-related apoptosis-inducing ligand-medaited apoptosis in oral squamous cell carcinoma cells treated with phosphatidylinositol 3-kinase inhibitors2007
- Author(s)
  Uchida M, Iwase M, Takaoka S, Yoshiba S, Kondo G, Watanabe H, Ohashi M, Nagumo M, Shintani S.
- Journal Title
  
  Int J Oncol 30
  
  Pages: 1163-1171
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390524
[Journal Article] Effect of combining epidermal growth factor receptor inhibitors and cisplatin on proliferation and apoptosis of oral squamous cell carcinoma cells2007
- Author(s)
  Takaoka S, Iwase M, Uchida M, Yoshiba S, Kondo G, Watanabe H, Ohashi M, Nagumo M, Shintani S.
- Journal Title
  
  Int J Oncol 30
  
  Pages: 1469-1476
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390524
[Journal Article] Regulation of Fas-mediated apoptosis in neutrophils after surgery-induced acute inflammation2006
- Author(s)
  Iwase M, Kondo G, et al.
- Journal Title
  
  Journal of Surgical Research 34
  
  Pages: 114-123
- Data Source
  KAKENHI-PROJECT-18592200
[Journal Article] Accelerative effect of selective cyclooxygenase-2 inhibitor on Fas-mediated apoptosis in human neutrophils2006
- Author(s)
  Iwase M, Takaoka S, et al.
- Journal Title
  
  International Immunopharmacology 6
  
  Pages: 334-341
- Data Source
  KAKENHI-PROJECT-18592200
[Journal Article] Accelerative effect of a selective cyclooxygenase-2 inhibitor on Fas-mediated apoptosis in human neutrophils.2006
- Author(s)
  Iwase M et al.
- Journal Title
  
  Int Immunopharmacology 6(3)
  
  Pages: 334-341
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209070
[Journal Article] Accelerative effect of selective cyclooxygenase-2 inhibitor on Fas-mediated apoptosis in human neutrophils2006
- Author(s)
  Iwase M et al.
- Journal Title
  
  Int Immunopharmacol 6
  
  Pages: 334-341
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209070
[Journal Article] Enhanced susceptivility of oral squamous cell carcinoma cell lines to Fas-mediated apoptosis by cisplatin and 5-fluorouracil2003
- Author(s)
  Iwase M et al.
- Journal Title
  
  Int J Cancer 106
  
  Pages: 619-625
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209070
[Journal Article] Enhanced susuceptibilitu of oral squamous cell carcinoma cel lines to Fas-mediated apoptosis by cisplatin and 5-fuluorouracil.2003
- Author(s)
  Iwase M et al.
- Journal Title
  
  Int J Cancer 106(4)
  
  Pages: 619-625
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209070
[Presentation] デスレセプター誘導アポトーシス感受性の増強による扁平上皮癌に対する分子標的治療の開発に関する研究2009
- Author(s)
  岩瀬正泰、近藤元、高岡清佳、内田真紀子、葭葉清香、代田達夫、羽鳥仁志、新谷悟
- Organizer
  昭和大学歯学部ハイテク・リサーチ・センター平成20年度研究成果発表会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19390524
[Presentation] Enhanced susceptibility to TRAIL-mediated apoptosis in oral squamous cell carcinoma cells through down-regulation of cellular FLIP2009
- Author(s)
  MASAYASU IWASE, SAYAKA TAKAOKA, MAKIKO UCHIDA, SAYAKA YOSHIBA, TATSUO SHIROTA, MASASHI HATORI, SATORU SHINTANI
- Organizer
  2nd World Congress of the International Academy of Oral Oncology
- Place of Presentation
  Toronto, Canada
- Data Source
  KAKENHI-PROJECT-21592562
[Presentation] Enhanced susceptibility to TRAIL-mediated apoptosis in oral squamous cell carcinoma cells through down-regulation of cellular FLIP.2009
- Author(s)
  Iwase M, Takaoka S, et al.
- Organizer
  2nd World Congress of Oral Oncology
- Place of Presentation
  Toronto, Canada
- Data Source
  KAKENHI-PROJECT-21592562
[Presentation] Enhanced susceptibility to TRAIL-mediated apoptosis in oral squamous cell carcinoma cells through down-regulation of cellular FLIP2007
- Author(s)
  Iwase M, Takaoka S, Uchida M, Yoshiba S, Shirota T, Hatori M, Shintani S.
- Organizer
  19th AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
- Place of Presentation
  San Francisco, CA
- Data Source
  KAKENHI-PROJECT-19390524

1. NAGUMO Masao (70013993)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
2. ITO Daisuke (40286844)

# of Collaborated Projects: 5 results

# of Collaborated Products: 1 results
3. KAMIJO Ryutaro (70233939)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. HATORI Masashi (20245814)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
5. SHINTANI Satoru (80294429)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
6. NAKAMURA Masako (80286856)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KURABAYASHI Hitomi (20255889)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. MOROHASHI Tomio (10146871)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. SAITO Shigeru (20195986)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. SEKI Kenji (00245820)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. ITO Hidetoshi (80384303)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. SAKURADA Shigeyo (00112730)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. YAGAMI Kimitoshi (00210211)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TACHIBANA Hideharu (70317577)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. OHASHI Masaru (40317524)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. TANAKA Norio (60343498)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. ODANI Takeshi (40407440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 栗原祐史 (90514969)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. 河野葉子 (40195681)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 西村明之 (50150652)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 大島修 (50167300)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 掘雅人 (10276602)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

IWASE Masayasu 岩瀬 正泰

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Antitumor effect of neutrophil-derived TRAIL for oral squamous cell carcinomaPrincipal Investigator

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Study of apoptotic induction through siRNA of c-FLIP in squamous cell carcinoma cellsPrincipal Investigator

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MECHANISM OF PROLONGED INFLAMMATION IN THE ORAL:EFFECT OF NEUTROPHIL APOPTOSIS ON ENDOTHELIAI CELLSPrincipal Investigator

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Pathogenic mechanism of oral severe infection: Analysis of phagocytic process for apoptotic neutrophilsPrincipal Investigator

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Pothogenic mechanism of oral severe infection : Effect of oxidativc stress on neutrophil apoptosis.Principal Investigator

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IWASE Masayasu 岩瀬正泰