TAMURA Toshiki 田村敏生

… Alternative Names

田村敏生タムラトシキ

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Researcher Number	40291306
Other IDs
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立感染症研究所ハンセン病研究センター, 室長
Affiliation (based on the past Project Information) *help	2016 – 2018: 国立感染症研究所, ハンセン病研究センター感染制御部, 室長 2009: ハンセン病研究センター, 室長 2008: 国立感染症研究所, ハンセン病研究センター, 室長 2008: 富山大学, ハンセン病研究センター, 室長 2007: 国立感染症研究所, ハンセン病研究所センター, 室長 2005 – 2006: 国立感染症研究所, ハンセン病研究センター, 室長 1997 – 2005: 東京大学, 医科学研究所, 助手
Review Section/Research Field	Principal Investigator Experimental pathology Except Principal Investigator Biological Sciences / Bacteriology (including mycology) / Immunology / Immunology
Keywords	Principal Investigator IL-12 / Autoantibody / Gene therapy / Superantigen / Lympadenopathy / Glomerulonephritis / MRL-lprィイD1cgィエD1 mice / Autoimmune disease / 免疫複合体 / 可溶性CD4 … More / CD4欠損変異 / lpr^<cg>遺伝子 / IL-1 / 1pr^<cg>マウス / IL-12p40 / リンパ節腫脹 / スーパー抗原 / 自己抗体 / CD4T細胞 / 糸球体腎炎 / lpr^<cg>マウス / 自己免疫病 … More Except Principal Investigator トランスジェニックマウス / IFN-γ / Peptide-25 / Ag85B / 結核菌 / CD152 / CD28 / B7 / IL-12p35 / I-A拘束性 / Th1抗原ペプチド / 細胞障害活性 / アジュバント活性 / 免疫学 / パーシスター / 潜伏 / 潜在性 / ワクチン / 無症候感染 / 抗酸菌 / 発症 / 休眠 / 潜伏感染 / ヒストン様蛋白質 / 天然変性蛋白質 / LTBI / 潜在性結核 / 非結核性抗酸菌症 / ハンセン病 / 結核 / Cytotoxic Activity / Transgenic mice / Adjuvant Activity / I-A restriction / Thl-indicing Peptide / CTL / IFNγ / ペプチド-25 / ヘルパーT細胞 / α抗原 / TCRVβ11 / CpG DNA / CLT / IL-12 independent TH1 differentiation / MHC class II / IL-2p40 / T細胞上B7-2発現 / T細胞抗原受容体 / 副刺激 / B7刺激 / IL-12Rβ2 / IL-12受容体 / IL-12非依存性Th1分化 / MHCクラスII / IL-12p40 / CD40-CD40L / アジュバント効果 / IFN--γ / 癌 / 抗腫瘍免疫増強 / クロスプレゼンテーション / 抗原提示細胞 / Th2 / Th1 / APS / Lnk / クラススイッチ組換え / IgA / Bリンパ球 / IL-5 / 造血幹細胞 / クラススイッチ / B-1細胞 / インターロイキン5 / リンパ球 / クラススイッチ変換 / アダプター分子 / インターロイキン / 自然免疫 Less

Study of tuberculosis latency and development of anti-tuberculosis strategy by keeping latent state
- Principal Investigator
  
  Matsumoto Sohkichi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Niigata University
Enhancement of Th1 and antitumor immunity by Ag85B and Peptide-25.
- Principal Investigator
  
  TAKATSU Kiyoshi
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Toyama
  The University of Tokyo
Investigation of regulatory mechanisms for homeostasis and activation of lymphocyte
- Principal Investigator
  
  TAKATSU Kiyoshi
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
  University of Toyama
Augmented Induction of CD8+ Cytotoxic T cell Response and Antitumor Resistance by Thl-inducing peptide
- Principal Investigator
  
  TAKATSU Eyoshi
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tokyo
Elucidation of the mechanism how Vβ T cells aggravate autoimmune diseases and establishment of T cell receptor (TCR)-targeted gene therapies of autoimmune diseasesPrincipal Investigator
- Principal Investigator
  
  TAMURA Toshiki, 松澤昭雄
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  The University of Tokyo
Elucidation of T cell subset Th1 differentiation by IL-12
- Principal Investigator
  
  NARIUCHI Hideo
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo

All 2018 2010 2008 2007 2006 2005 2004 2003 2001

All Journal Article Presentation

[Journal Article] Lnk regulates integrin αIIbβ3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo2010
- Author(s)
  Takizawa H, Nishimura S, Takayama N, Oda A, Nishikii H, Morita Y, Kakinuma S, Yamazaki S, Okumura S, Tamura N, Goto S, Sawaguchi A, Manabe I, Takatsu K, Nakauchi H, Takaki S, Eto K
- Journal Title
  
  The Journal of Clinical Investigation 120
  
  Pages: 179-190
- NAID
  120003783344
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013024
[Journal Article] Suppressed induction of mycobacterial antigen-specific Th1-type CD4 + T cells in the lung after pulmonary mycobacterial infection2010
- Author(s)
  Yahagi A, Umemura M, Tamura T, Kariyone A, Begum MD, Kawakami K, Okamoto Y, Hamada S, Oshiro K, Kohama H, Arakawa T, Ohara N, Takatsu K, Matsuzaki G
- Journal Title
  
  International Immunology 22
  
  Pages: 307-308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013024
[Journal Article] Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs2008
- Author(s)
  Wolf AJ, Desvignes L, Linas B, Banaiee N, Tamura T, Takatsu K, Ernst JD
- Journal Title
  
  Journal of Experimental Medicine 20
  
  Pages: 288-294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013024
[Journal Article] CpG ODN mediated prevention from ovalbumin-induced anaphylaxis in mouse through B cell pathway2008
- Author(s)
  Xu W, Tamura T, Takatsu K
- Journal Title
  
  International Immunopharmacology 8
  
  Pages: 351-361
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013024
[Journal Article] Initiation of the adaptive immune response to M. tuberculosis depends on antigen production in the local lymph node, not the lungs2008
- Author(s)
  Wolf, AJ, Desvignes L, Linas B, Banaiee N, Tamura T, Takatsu K, Ernst JD
- Journal Title
  
  J. Exp. Med 205
  
  Pages: 105-115
- Data Source
  KAKENHI-PROJECT-16109004
[Journal Article] Mycobacterium tuberculosis infects dendritic cells with high frequency and impairs their function in vivo2007
- Author(s)
  Wolf AJ, Linas B, Trevejo-Nunez GJ, Kincaid E, Tamura T, Takatsu K, Ernst JD
- Journal Title
  
  Journal of Immunology 179
  
  Pages: 2509-2519
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013024
[Journal Article] Instruction of naive CD4+ T-cell fate to T-bet expression and T helper 1 development: roles of T-cell receptor-mediated signals2007
- Author(s)
  Ariga H, Shimohakamada Y, Nakada M, Tokunaga T, Kariyone A, Tamura T, Takatsu K
- Journal Title
  
  Immunology 122
  
  Pages: 210-221
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013024
[Journal Article] Instruction of CD4^+ T cell fate to T-bet expression and Th1 development by Th1-inducing peptide : roles of T cell receptor-mediated signals2007
- Author(s)
  Ariga H, Shimohakamada Y, Tokunaga T, Kikuchi T, Nakata M, Kariyone A, Tamura T, Takatsu K
- Journal Title
  
  Immunology 122
  
  Pages: 210-221
- Data Source
  KAKENHI-PROJECT-16109004
[Journal Article] Augmented induction of CD8+ cytotoxic T-cell response and antitumour resistance by T helper type 1- inducing peptide2006
- Author(s)
  Kikuchi T, Uehara S, Ariga H, Tokunaga T, Kariyone A, Tamura T, Takatsu K
- Journal Title
  
  Immunology 117
  
  Pages: 47-58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013024
[Journal Article] The role of antigenic peptide in CD4<SUP>+</SUP> T helper phenotype development in a T cell receptor transgenic model2004
- Author(s)
  Tamura, T., Ariga, H., Kariyone, A., Takatsu, K.et al.
- Journal Title
  
  International Immunology 16・12
  
  Pages: 1691-1699
- NAID
  10014207554
- Data Source
  KAKENHI-PROJECT-12213025
[Journal Article] The role of antigenic peptide in CD4+ T helper phenotype development in a T cell receptor transgenic model.2004
- Author(s)
  Tamura, T., Ariga, H., Kinashi, T., Uehara, S., Kikuchi, T., Nakada, M., Tokunaga, T., Xu, W., Kariyone, A., Saito, T., Kitamura, T., Maxwell, G., Takaki, S., Takatsu, K.
- Journal Title
  
  International Immunology 16(12)
  
  Pages: 1691-1699
- NAID
  10014207554
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213025
[Journal Article] The role of antigenic peptide in CD4^+ T helper phenotype development in a T cell receptor transgenic model2004
- Author(s)
  Tamura T, Ariga H, Kinashi T, Uehara S, Kikuchi T, Nakada M, Tokunaga T, Kariyone A, Saito T, Kitamura T, Maxwell G, Takaki S, Takatsu K
- Journal Title
  
  Int. Immunol 15
  
  Pages: 1691-1699
- NAID
  10014207554
- Data Source
  KAKENHI-PROJECT-16109004
[Journal Article] The role of antigenic peptide in CD4^+ T helper phenotype development in a T cell receptor transgenic model2004
- Author(s)
  Tamura. T
- Journal Title
  
  Int.Immunol 15
  
  Pages: 1691-1699
- NAID
  10014207554
- Data Source
  KAKENHI-PROJECT-16109004
[Journal Article] The role of antigenic peptide in CD4^+ T helper phenotype development in a T cell receptor transgenic model2004
- Author(s)
  Tamura, T., Ariga, H., Kariyone, A., Takatsu, K.et al.
- Journal Title
  
  International Immunology 16・12
  
  Pages: 1691-1699
- NAID
  10014207554
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12213025
[Journal Article] Immunogenicity of Peptide-25 of Ag85B in Th1 development : role of IFN-γ2003
- Author(s)
  Kariyone, A., Tamura, T., Kano, H., Takatsu, K.et al.
- Journal Title
  
  International Immunology 15・10
  
  Pages: 1183-1194
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12213025
[Journal Article] Immunogenicity of Peptide-25 of Ag85B in Thl development : role of IFN-y.2003
- Author(s)
  Kariyone, A., Tamura, T., Kano, H., Iwakura, Y., Takeda, K., Akira, S., Takatsu, K.
- Journal Title
  
  International Immunolology 15(10)
  
  Pages: 1183-1194
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213025
[Journal Article] Impairment in the expression and activity of Fyn during Differentiation of naive CD4^+ T cells into the Th2 subset.2001
- Author(s)
  Tamura, T., Igarashi, O., Hino, A., Nariuchi, H., et al.
- Journal Title
  
  Journal of Immunology 167・4
  
  Pages: 1962-1969
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12213025
[Journal Article] Impairment in the expression and activity of Fyn during differentiation of naive CD4+ T cells into the Th2 subset.2001
- Author(s)
  Tamura, T., Igarashi, 0., Hino, A., Yamane, H., Aizawa, S., Kato, T., Nariuchi, H.
- Journal Title
  
  Journal of Immunolology 167(4)
  
  Pages: 1962-1969
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213025
[Presentation] The effects of booster vaccine composed of MDP1 and G9.1 against tuberculosis in cynomogus monkeys.2018
- Author(s)
  Daisuke Hayashi, Jun-ichi Maeyama, Toshiko Yamamoto, Toshio Yamazaki, Tetsu Mukai, Toshiki Tamura, Sachi Okabayashi, Fumiko Suzuki, Yuriko Ozeki, Akira Yokoyama, Yuriko Suzaki, Yasushi Ami, Yoshitaka Goto, Sumiko Iho, Sohkichi Matsumoto and Saburo Yamamoto.
- Organizer
  US-Japan Cooperative Medical Science Program, 52nd Mycobacteria Panel Meeting,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05187
[Presentation] P25CD4^+T細胞活性化とクロスプライミング増強の解析2007
- Author(s)
  刈米アイ、田村敏生、高津聖志
- Organizer
  第37回日本免疫学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-16109004
[Presentation] Ag85B由来Peptide-25によるクロスプライミング増強効果の解析2006
- Author(s)
  刈米アイ、田村敏生、高津聖志
- Organizer
  第36回日本免疫学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-16109004
[Presentation] Role of T-cell receptor singal and T-bet in the induction of Th1 differentiation and cross-priming of antigen2006
- Author(s)
  akatsu K, Ariga H, Shimohakamada Y, Nakada M, Tokunaga T, Kikuchi T, Kariyone A, Tamura T
- Organizer
  RCAI-JSI International symposium on immunology
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2006-06-17
- Data Source
  KAKENHI-PROJECT-17013024
[Presentation] TCRシグナルを介するTh1分化における転写因子T-betの役割 : T-betノックアウトマウスを用いた解析2005
- Author(s)
  下袴田陽子、徳永岳史、仲田真己代、有賀晴之、刈米アイ、田村敏生、高津聖志
- Organizer
  第35回日本免疫学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-16109004

1. TAKATSU Kiyoshi (10107055)

# of Collaborated Projects: 3 results

# of Collaborated Products: 18 results
2. KARIYONE Ai (50114450)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
3. TAKAKI Satoshi (10242116)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. NAGAI Yoshinori (30431761)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. YOSHIMOTO Takayuki (80202406)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. KOURO Taku (90372424)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. IKUTANI Masashi (40513718)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. HONDA Hiroe (10463134)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. NARIUCHI Hideo (10012741)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. NAKANO Hideki (30266928)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Matsumoto Sohkichi (30244073)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 松澤昭雄 (50012745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 阿戸学 (20392318)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 西山晃史 (80452069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Mekura Ryoji

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. Ozeki Yuriko

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. Katahira Masato

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. Yamaguchi Takehiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TAMURA Toshiki 田村 敏生

田村 敏生 タムラ トシキ

Research Projects

Research Products

Co-Researchers

Study of tuberculosis latency and development of anti-tuberculosis strategy by keeping latent state

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Enhancement of Th1 and antitumor immunity by Ag85B and Peptide-25.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of regulatory mechanisms for homeostasis and activation of lymphocyte

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Augmented Induction of CD8+ Cytotoxic T cell Response and Antitumor Resistance by Thl-inducing peptide

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism how Vβ T cells aggravate autoimmune diseases and establishment of T cell receptor (TCR)-targeted gene therapies of autoimmune diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of T cell subset Th1 differentiation by IL-12

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Lnk regulates integrin αIIbβ3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Suppressed induction of mycobacterial antigen-specific Th1-type CD4 + T cells in the lung after pulmonary mycobacterial infection2010

Author(s)

Journal Title

Data Source

[Journal Article] Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs2008

Author(s)

Journal Title

Data Source

[Journal Article] CpG ODN mediated prevention from ovalbumin-induced anaphylaxis in mouse through B cell pathway2008

Author(s)

Journal Title

Data Source

[Journal Article] Initiation of the adaptive immune response to M. tuberculosis depends on antigen production in the local lymph node, not the lungs2008

Author(s)

Journal Title

Data Source

[Journal Article] Mycobacterium tuberculosis infects dendritic cells with high frequency and impairs their function in vivo2007

Author(s)

Journal Title

Data Source

[Journal Article] Instruction of naive CD4+ T-cell fate to T-bet expression and T helper 1 development: roles of T-cell receptor-mediated signals2007

Author(s)

Journal Title

Data Source

[Journal Article] Instruction of CD4^+ T cell fate to T-bet expression and Th1 development by Th1-inducing peptide : roles of T cell receptor-mediated signals2007

Author(s)

Journal Title

Data Source

[Journal Article] Augmented induction of CD8+ cytotoxic T-cell response and antitumour resistance by T helper type 1- inducing peptide2006

Author(s)

Journal Title

Data Source

[Journal Article] The role of antigenic peptide in CD4<SUP>+</SUP> T helper phenotype development in a T cell receptor transgenic model2004

Author(s)

TAMURA Toshiki 田村敏生

田村敏生タムラトシキ