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SHIMIZU TAKAHIKO  清水 孝彦

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SHIMIZU Takahiko  清水 孝彦

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Researcher Number 40301791
Other IDs
Affiliation (Current) 2025: 順天堂大学, 大学院医学研究科, 特任教授
Affiliation (based on the past Project Information) *help 2025: 順天堂大学, 大学院医学研究科, 特任教授
2022 – 2023: 国立研究開発法人国立長寿医療研究センター, 研究所 老化ストレス応答研究プロジェクトチーム, プロジェクトリーダー
2020 – 2021: 国立研究開発法人国立長寿医療研究センター, 老化ストレス応答研究プロジェクトチーム, プロジェクトリーダー
2017 – 2019: 千葉大学, 大学院医学研究院, 講師
2017: 千葉大学, 医学部, 客員准教授 … More
2015 – 2016: 千葉大学, 医学(系)研究科(研究院), 准教授
2015 – 2016: 千葉大学, 医学(系)研究科(研究院), 特任准教授
2015 – 2016: 千葉大学, 大学院医学研究院, 特任准教授
2015: 千葉大学, 医学科研究院, 准教授
2014: 千葉大学, 医学(系)研究科(研究院), 客員准教授
2014: 千葉大学, 医学部, 准教授
2014: 千葉大学, 大学院医学研究院先進加齢医学講座, 准教授
2013 – 2014: 千葉大学, 医学(系)研究科(研究院), 寄附講座教員
2012 – 2014: 千葉大学, 医学(系)研究科(研究院), その他
2013: 千葉大学, 大学院・医学系研究科, 客員准教授
2013: 千葉大学, 大学院医学研究院, 寄附講座教員
2012: 千葉大学, 医学(系)研究科(研究院), 准教授
2012: 千葉大学, 医学(系)研究科(研究院), 客員准教授
2012: 千葉大学, 医学研究科, 客員准教授
2012: 千葉大学, 大学院・医学研究院, 客員准教授
2011: 千葉大学, 医学研究院, 准教授
2011: 千葉大学, 医学部, 客員准教授
2011: 千葉大学, 大学院・医学研究科, 准教授
2010 – 2011: Tokyo Metropolitan Institute of Gerontology, 東京都健康長寿医療センター研究所, 研究員
2010: 地方独立法人東京都健康長寿医療センター, 東京都健康長寿医療センター研究所, 研究員
2010: 東京都健康長寿医療センター研究所, 研究員
2010: 財団法人東京都高齢者研究・福祉振興財団, 東京都老人総合研究所, 研究員
2008 – 2010: Tokyo Metropolitan Institute of Gerontology, 東京都老人総合研究所, 研究員
2008 – 2010: 地方独立行政法人東京都健康長寿医療センター, 東京都健康長寿医療センター研究所, 研究員
2009: 地方独立行政法人東京都健康長寿医療センター(東京都, 研究員
2007: (財)東京都高齢者研究・福祉振興財団, 東京都・老人総合研究所, 研究員
2005 – 2006: (財)東京都高齢者研究・福祉振興財団, 東京都老人総合研究所, 研究員
2005: 東京都老人総合研究所, 分子老化研究グループ, 研究員
2005: Tokyo Metropolitan Institute of Gerontology, Department of Molecular Gerontology, Researcher, 福祉振興財団・東京都老人総合研究所分子老化研究グループ, 研究員
2004: 財団法人東京都高齢者研究, 福祉振興財団・東京都老人総合研究所, 研究員
2004: 財団法人東京都高齢者研究, 福祉振興財団・東京都老人総合研究所・分子老化研究グループ, 研究員
2002 – 2003: (財)東京都高齢者研究・福祉振興財団, 東京都老人総合研究所・分子老化研究グループ, 研究員
2002 – 2003: 東京都老人総合研究所, 分子老化部門, 研究員
2001: 東京都老人総合研究所, 分子遺伝学部門, 研究員
1999: 財団法人 東京都老人総合研究所, 分子遺伝学部門, 研究員
1999: Tokyo Metropolitan Institute of Gerontology, Department of Molecular Genitics, Investigator., 分子遺伝子学部門, 研究員
1998: 東京都老人総合研究所, 分子遺伝学部門, 研究員 Less
Review Section/Research Field
Principal Investigator
General medical chemistry / Basic Section 59040:Nutrition science and health science-related / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Basic Section 52010:General internal medicine-related / 老化(加齢) / Orthopaedic surgery / Applied health science / Neurology
Except Principal Investigator
Bioproduction chemistry/Bioorganic chemistry / General internal medicine(including psychosomatic medicine) … More / Orthopaedic surgery / Gastroenterology / General medical chemistry / Bioproduction chemistry/Bioorganic chemistry / Bioorganic chemistry / Neurology / Periodontology / General internal medicine (including Psychosomatic medicine) / Integrated Nutrition Science / ケミカルバイオロジー / Biomedical engineering/Biological material science / Biological Sciences Less
Keywords
Principal Investigator
ミトコンドリア / 骨格筋 / 酸化ストレス / 神経変性 / 骨細胞 / SOD / 活性酸素 / MnSOD / 遺伝子治療 / ノックアウトマウス … More / イソアスパラギン酸メチル転移酵素 / イソアスパラギン酸 / 老化 / SOD2 / グリコーゲンフォスフォリラーぜ / グリコーゲン代謝 / ミトコンドリアROS / 組織連関 / 細胞老化 / ストレス応答 / Amyloid fibril / Isomerization / Aggregation / Senile plaques / Amyloid-bearing vessels / Alzheimer's disease / Amyloid β-protein / Isoaspartic acid / 脳 / アデノウイルス / βアミロイド蛋白質 / アミロイド繊維 / 血管アミロイド / アミロイドβ蛋白質 / アルミロイド繊維 / 異性化 / 凝集 / 老人斑 / 血管アルミロイド / アルツハイマー病 / アルミロイドβ蛋白質 / 骨 / 運動能力 / ATP / 加齢 / モデルマウス / 運動器老化 / Cre-loxP / ドーパミン産生細胞 / パーキンソン病 / 個体老化 / 脳特異的欠損マウス / Cre-loxpシステム / シナプス / シナプシン1 / トランスジェニックマウス / 翻訳後修飾 … More
Except Principal Investigator
酸化ストレス / 凝集 / Aβ42 / 老化 / アルツハイマー / βアミロイド / アルツハイマー病 / β-sheet / ミトコンドリア / オリゴマー / アミロイドβ / DARR / Cre-loxP / turn / amyloid / Alzheimer's disease / ターン / ベータシート / 早老症 / 老年医学 / Mn-SOD / iPS細胞 / 核酸アプタマー / 活性酸素 / 遺伝子 / 骨粗鬆症 / フラボノイド / 抗体 / 毒性ターン / モデルマウス / 加齢 / タキシフォリン / β-シート / 固体NMR / ラジカル / 細胞老化 / コレステロール / 肝臓癌 / 類洞内皮細胞 / アセトアミノフェン肝障害 / TLR9 / 遊離コレステロール / 非アルコール性脂肪肝炎 / 分化 / 間葉系幹細胞 / マーモセット / 動脈硬化 / ウェルナー症候群 / ATP synthesis / Apoptosis / Respiratory complex / Mitochondria / Aging / Superoxide / ATP合成 / アポトーシス / 呼吸鎖複合体 / 活性酵素 / MnSOD / solid-state NMR / aggregation / familial Alzheimer's disease / Aβ1-42 / 家族性アルツハイマー病 / β-turn / 家族性アルツハイマー / アミロイド / ウェルナー / 神経細胞毒性 / 毒性オリゴマー / ノックインマウス / 有機化学 / 脳神経疾患 / 診断 / 脳脊髄液 / DJ-1 / パーキンソン病 / 歯周組織 / セメント質肥大 / セメント芽細胞 / SOD2 / SOD2 / セメント質 / 骨代謝 / 破骨細胞 / 骨芽細胞 / 骨細胞 / 遺伝子発現 / 早老症候群 / Werner症候群 / マウス / 酸素消費 / 老化機構 / コエンザイムQ / 酸素消費量 / ミトコンドリア機能低下 / クロック-1遺伝子 / トランスジェニックマウス / 骨格筋 / 脳 / 代謝 / コエンザイムQ / 寿命 / インスリン受容体 / ビタミンC / 光親和性標識 / スーパーオキシドラジカル / 細胞質SOD / アルキン / アジド / フイスゲン反応 / プロドラッグ / 白金 / Huisgen反応 / ジアミノピペリン酸 / RNA / アプタマー / アミロイド β / キャリア / 抗酸化 / 酵素 / CuZn-SOD / スーパーオキサイドディスムターゼ(SOD) / 光アフィニティーラベリング / 毒性コンホマー / 抗ターン抗体 / アプリシアトキシン / シナプス毒性 / クルクミン / プロテインキナーゼC / カテコール / 凝集抑制 / シグナル伝達 / 糖尿病 / 内科 / 肝再生 / 肝細胞癌 / 急性肝障害 / 脂肪肝炎 / インスリン抵抗性 / レプチン / 肥満 / SOD / NASH / 脂肪肝 / スピンラベル / シリマリン / βシート / R2 / β-シ-ト / アルツハイマ-病 / ESR / Aβ抗体 / ターン形成 / 電子スピン共鳴法 Less
  • Research Projects

    (29 results)
  • Research Products

    (307 results)
  • Co-Researchers

    (40 People)
  •  Elucidation of the Regulatory Mechanism of Muscle Glycogen Metabolism by Mitochondrial ROSPrincipal Investigator

    • Principal Investigator
      清水 孝彦
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Juntendo University
  •  骨細胞由来の骨格筋恒常性阻害因子の探索研究Principal Investigator

    • Principal Investigator
      清水 孝彦
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
    • Research Institution
      National Center for Geriatrics and Gerontology
  •  Molecular mechanism of osteocyte senescence by mitochondrial retrograde signalingPrincipal Investigator

    • Principal Investigator
      Shimizu Takahiko
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52010:General internal medicine-related
    • Research Institution
      National Center for Geriatrics and Gerontology
  •  Elucidation of molecular pathology of aging and diseases based on multi-dimensional analysis of progeroid syndromes

    • Principal Investigator
      Yokote Koutaro
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      General internal medicine(including psychosomatic medicine)
    • Research Institution
      Chiba University
  •  Establishment of novel therapies for steatohepatitis and liver cancer, by targeting the free cholesterol-mediated signaling pathway.

    • Principal Investigator
      Tomita Kengo
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      National Defense Medical College
  •  Novel Preventive Strategy for Alzheimer's Disease Based on the Toxic Conformation Theory of Amyloid beta

    • Principal Investigator
      Irie Kazuhiro
    • Project Period (FY)
      2014 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Bioorganic chemistry
    • Research Institution
      Kyoto University
  •  Pathological elucidation of age-related diseases by integrative analyses of senescence genes

    • Principal Investigator
      Yokote Koutaro
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General internal medicine(including psychosomatic medicine)
    • Research Institution
      Chiba University
  •  Oxidative stress in bone regulates skeletal homeostasis in micePrincipal Investigator

    • Principal Investigator
      Shimizu Takahiko
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Chiba University
  •  The functional analysis of SOD2, antioxidantdefense in periodontal tissue

    • Principal Investigator
      USUI MICHIHIKO
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Periodontology
    • Research Institution
      Kyushu Dental College
  •  To generate and analyze new Parkinson's disease mice model with increased oxidative stress

    • Principal Investigator
      YAMAGUCHI Hiroo
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Neurology
    • Research Institution
      Kyushu University
  •  Establishment of disease iPS cells and molecular analysis of age-related changes in progeroid syndrome

    • Principal Investigator
      YOKOTE Koutaro
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      General internal medicine (including Psychosomatic medicine)
    • Research Institution
      Chiba University
  •  The role of oxidative stress in the maintenance of bone metabolism

    • Principal Investigator
      SAITA Yoshitomo
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Juntendo University
  •  Effects of coenzyme Q on aging in mammls

    • Principal Investigator
      TAKAHASHI Mayumi
    • Project Period (FY)
      2011 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Integrated Nutrition Science
    • Research Institution
      Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
  •  Mitochondria Treatment by Antioxidant with Multi-enzyme Activity

    • Principal Investigator
      KAWAKAMI Hiroyoshi
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biomedical engineering/Biological material science
    • Research Institution
      Tokyo Metropolitan University
  •  Development of RNA aptamer against toxic Aβ oligomer

    • Principal Investigator
      MURAKAMI Kazuma
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      ケミカルバイオロジー
    • Research Institution
      Kyoto University
  •  Development of medicinal seeds for Alzheimer's disease based on the structural analysis of toxic oligomers of amyloid beta

    • Principal Investigator
      IRIE Kazuhiro
    • Project Period (FY)
      2009 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Bioproduction chemistry/Bioorganic chemistry
    • Research Institution
      Kyoto University
  •  The development and analyses of the mouse model of age-related osteoporosis.

    • Principal Investigator
      SAITA Yoshitomo
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Juntendo University
  •  Molecular mechanism for aging control

    • Principal Investigator
      SHIRASAWA Takuji
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Juntendo University
  •  Oxidative stress in skeletal muscle causes severe disturbance of exercise activityPrincipal Investigator

    • Principal Investigator
      SHIMIZU Takahiko
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied health science
    • Research Institution
      Tokyo Metropolitan Institute of Gerontology
  •  Analysis of the paradoxical correlation between hepatic insulin resistance and oxidative stress in the pathogenesis of steatohepatitis

    • Principal Investigator
      TOMITA Kengo
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Keio University
  •  Development of antibodies and aggregation inhibitors for amyloid β peptides based on the new aggregation model

    • Principal Investigator
      IRIE Kazuhiro
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Bioproduction chemistry/Bioorganic chemistry
    • Research Institution
      Kyoto University
  •  アミロイドβ42凝集体のターン構造をエピトープとしたワクチン療法の開発

    • Principal Investigator
      SHIRASAWA Takuji
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Metropolitan Institute of Gerontology
  •  酸化ストレスによる神経変性の分子メカニズム解明Principal Investigator

    • Principal Investigator
      清水 孝彦
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Tokyo Metropolitan Institute of Gerontology
  •  Analysis of heart/muscle-specific Mn-SOD-deficient mice.

    • Principal Investigator
      SHIRASAWA Takuji
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Tokyo Metropolitan Foundation for Research on Aging and Promotion of Human Welfare
  •  Structural analysis of β-amyloid fibrils using solid-state NMR

    • Principal Investigator
      IRIE Kazuhiro
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Bioproduction chemistry/Bioorganic chemistry
    • Research Institution
      KYOTO UNIVERSITY
  •  脳酸化ストレス蓄積マウスの作製と解析Principal Investigator

    • Principal Investigator
      清水 孝彦
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Tokyo Metropolitan Institute of Gerontology
  •  神経変性モデルマウスに蓄積した変性タンパク質の同定Principal Investigator

    • Principal Investigator
      清水 孝彦
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Neurology
    • Research Institution
      Tokyo Metropolitan Institute of Gerontology
  •  Elucidation of aggregation mechanism of Alzheimer's β-peptides and development of their aggregation inhibitors

    • Principal Investigator
      IRIE Kazuhiro
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Bioproduction chemistry/Bioorganic chemistry
    • Research Institution
      Kyoto University
  •  Identification of isoaspartic acid containing proteins in aged brainPrincipal Investigator

    • Principal Investigator
      SHIMIZU Takahiko
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      老化(加齢)
    • Research Institution
      Tokyo Metropolitan Institute of Gerontology

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book Patent

  • [Book] ミトコンドリアダイナミクス2021

    • Author(s)
      渡辺憲史, 澁谷修一, 清水孝彦
    • Publisher
      エヌ・ティー・エス
    • ISBN
      4860437462
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Book] 老化遺伝子,新老年学「第3版」編集代表:大内尉義、秋山弘子2010

    • Author(s)
      清水孝彦、白澤卓二
    • Publisher
      東京大学出版会
    • Data Source
      KAKENHI-PROJECT-20500641
  • [Book] 新老年学「第3版」2010

    • Author(s)
      清水孝彦, ら
    • Publisher
      東京大学出版会
    • Data Source
      KAKENHI-PROJECT-20390085
  • [Book] 臓器老化モデルマウスを用いた抗老化食品の探索49巻1号2010

    • Author(s)
      清水孝彦
    • Publisher
      化学と生物化学と生物編集部
    • Data Source
      KAKENHI-PROJECT-20500641
  • [Book] Mn-SODコンディショナルノックアウトマウスを用いた抗老化研究130巻1号2010

    • Author(s)
      清水孝彦、白澤卓二
    • Publisher
      薬学雑誌日本薬学会
    • Data Source
      KAKENHI-PROJECT-20500641
  • [Book] 新老年学「第3版」2010

    • Author(s)
      清水孝彦, ら
    • Publisher
      東京大学出版会
    • Data Source
      KAKENHI-PROJECT-20500641
  • [Book] 老化・老年病のための動物実験ガイドブック2008

    • Author(s)
      清水孝彦ら
    • Publisher
      アドスリー
    • Data Source
      KAKENHI-PROJECT-20390085
  • [Book] 酸化ストレスモデルマウス,老化・老年病研究のための動物実験ガイドブック2008

    • Author(s)
      清水孝彦、川上哲、白澤卓二
    • Publisher
      日本基礎老化学会編アドスリー社
    • Data Source
      KAKENHI-PROJECT-20500641
  • [Book] 'Malignant' conformation of Alzheimer's β peptide (Aβ42) through radical formation (H. Ishida and H. Mihara (Eds.))2006

    • Author(s)
      K. Murakami, *K. Irie, 他3名, T. Shimizu, T. Shirasawa
    • Publisher
      The Japanese Peptide Society
    • Data Source
      KAKENHI-PROJECT-18208011
  • [Book] Detection of amyloid beta peptides with L-isoaspartate in Alzheimer's disease2006

    • Author(s)
      Takahiko Shimizu
    • Publisher
      Nova Biomedical Books
    • Data Source
      KAKENHI-PROJECT-17790201
  • [Book] Detection of amyloid beta peptides with L-isoaspartate in Alzheimer's disease2006

    • Author(s)
      Takahiko Shimizu
    • Publisher
      Nova Biomedical Books
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390085
  • [Book] Detection of amyloid beta peptides with L-isoaspartate in Alzhemier's disease2006

    • Author(s)
      Takahiko Shimizu
    • Publisher
      Nova Biomedical Books
    • Data Source
      KAKENHI-PROJECT-17390085
  • [Journal Article] GDE5 activity determines phosphatidylcholine composition in skeletal muscle and regulates contractile force in mice.2024

    • Author(s)
      Aisyah, R., Ohshima, N., Watanabe, D., Nakagawa, Y., Sakuma, T., Nitschke, F., Nakamura, M., Sato, K., Nakahata, K., Yokoyama, C., Kumrungsee, K., Shimizu, T., Sotomaru, Y., Takeo, T., Nakagata, N., Izumi, T., Minassian, B.A., Miura, S., Yamamoto, T., Wada, M., and Yanaka, N.
    • Journal Title

      Commun. Biol

      Volume: in press

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Journal Article] SOD2 orchestrates redox homeostasis in intervertebral discs: A novel insight into oxidative stress-mediated degeneration and therapeutic potential.2024

    • Author(s)
      Tamagawa, S., Sakai, D., Nojiri, H., Nakamura, Y., Warita, T., Matsushita, E., Schol, J., Soma, H., Ogasawara, S., Munesada, D., Koike, M., Shimizu, T., Sato, M., Ishijima, M., Watanabe, M.
    • Journal Title

      Redox Biol

      Volume: 71 Pages: 103091-103091

    • DOI

      10.1016/j.redox.2024.103091

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19607, KAKENHI-PROJECT-20H03809
  • [Journal Article] Linagliptin exacerbates heart failure due to energy deficiency via downregulation of glucose utilization and absorption in a mouse model.2023

    • Author(s)
      Shiraki, A., Jun-ichi Oyama, J., Shimizu, T., Node, K.
    • Journal Title

      Eur J Pharmacol

      Volume: 948 Pages: 175673-175673

    • DOI

      10.1016/j.ejphar.2023.175673

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03583, KAKENHI-PROJECT-22K19607
  • [Journal Article] Detection of Dietary Chalcone and Flavonoid Metabolites in Mice Using UPLC-MS/MS and Their Modulatory Effects on Amyloid β Aggregation2023

    • Author(s)
      Taniwa Kota, Murakami Kazuma, Sakaguchi Yoshiki, Izuo Naotaka, Hanaki Mizuho, Sampa Nobuaki, Kume Toshiaki, Shimizu Takahiko, Irie Kazuhiro
    • Journal Title

      Journal of Agricultural and Food Chemistry

      Volume: 71 Issue: 39 Pages: 14289-14299

    • DOI

      10.1021/acs.jafc.3c02598

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-22K19607
  • [Journal Article] 骨格筋特異的SOD2欠損はミトコンドリア機能不全に伴う運動不耐を引き起こす2023

    • Author(s)
      澁谷修一、坂本一晃、渡辺憲史、野尻英俊、清水孝彦
    • Journal Title

      基礎老化研究誌

      Volume: 47 Pages: 32-34

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Journal Article] アンチエイジング研究の基礎2023

    • Author(s)
      清水孝彦
    • Journal Title

      J Mamm Ova Res

      Volume: 40 Pages: 27-33

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Journal Article] Functional analyses of food materials using progeria models2023

    • Author(s)
      清水孝彦
    • Journal Title

      Functional Food Research

      Volume: 19 Issue: 0 Pages: 5-9

    • DOI

      10.32153/ffr.ffr19_p5-9

    • ISSN
      2432-3357, 2434-3048
    • Year and Date
      2023-10-12
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Journal Article] 骨格筋特異的SOD2欠損はミトコンドリア機能不全に伴う運動不耐を引き起こす2023

    • Author(s)
      澁谷修一、坂本一晃、渡辺憲史、野尻英俊、清水孝彦
    • Journal Title

      基礎老化研究誌

      Volume: 47 Pages: 32-34

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Journal Article] Exploring for compounds that enhance motor function using muscle fatigue-model mice2023

    • Author(s)
      澁谷修一,渡辺憲史,桜庭大樹,阿部卓哉,清水孝彦
    • Journal Title

      Functional Food Research

      Volume: 19 Issue: 0 Pages: 45-49

    • DOI

      10.32153/ffr.ffr19_p45-49

    • ISSN
      2432-3357, 2434-3048
    • Year and Date
      2023-10-12
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Journal Article] Insulin resistance induces earlier initiation of cognitive dysfunction mediated by cholinergic deregulation in a mouse model of Alzheimer’s disease.2023

    • Author(s)
      Izuo, N., Watanabe, N., Noda, Y., Saito, T., Saido, T.C., Yokote, K., Hotta, H., Shimizu, T.
    • Journal Title

      Aging Cell

      Volume: 22 Issue: 11 Pages: 1-13

    • DOI

      10.1111/acel.13994

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K19607, KAKENHI-PROJECT-23K07007, KAKENHI-PROJECT-23K20363
  • [Journal Article] 大豆イソフラボンによる筋グリコーゲン代謝制御機構解明2022

    • Author(s)
      清水孝彦
    • Journal Title

      大豆たん白質研究

      Volume: -

    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Journal Article] 酸化ストレスと骨格筋老化2022

    • Author(s)
      清水孝彦, 渡辺憲史, 澁谷修一
    • Journal Title

      実験医学

      Volume: 40 Pages: 78-85

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Journal Article] Empagliflozin improves cardiac mitochondrial function and survival through energy regulation in a murine model of heart failure.2022

    • Author(s)
      Shiraki, A., Jun-ichi Oyama, J., Shimizu, T., Nakashima, T., Yokota, T., Node, K.
    • Journal Title

      Eur J Pharmacol

      Volume: 931 Pages: 175194-175194

    • DOI

      10.1016/j.ejphar.2022.175194

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K19607, KAKENHI-PROJECT-20H03583
  • [Journal Article] 加齢脳とストレス応答異常2022

    • Author(s)
      清水孝彦, 渡辺憲史, 澁谷修一
    • Journal Title

      老年精神医学雑誌

      Volume: 33 Pages: 947-955

    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Journal Article] 酸化ストレスと骨格筋老化2022

    • Author(s)
      清水孝彦, 渡辺憲史, 澁谷修一
    • Journal Title

      実験医学

      Volume: 40 Pages: 78-85

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Journal Article] 酸化ストレスと運動器老化 特集:老化はなぜ進むのか?2022

    • Author(s)
      清水孝彦, 澁谷修一, 渡辺憲史
    • Journal Title

      BIO Clinica

      Volume: 37 Pages: 1287-1292

    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Journal Article] 加齢脳とストレス応答異常2022

    • Author(s)
      清水孝彦, 渡辺憲史, 澁谷修一
    • Journal Title

      老年精神医学雑誌

      Volume: 33 Pages: 947-955

    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Journal Article] 酸化ストレスと運動器老化 特集:老化はなぜ進むのか?2022

    • Author(s)
      清水孝彦, 澁谷修一, 渡辺憲史
    • Journal Title

      BIO Clinica

      Volume: 37 Pages: 1287-1292

    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Journal Article] Lysine-targeting inhibition of amyloid β oligomerization by a green perilla-derived metastable chalcone in vitro and in vivo.2022

    • Author(s)
      Murakami, K., Sakaguchi, Y., Taniwa, K., Izuo, N., Hanaki, M., Kawase, T., Hirose, K., Nagao, C., Mizoguchi, K., Shimizu, T., Irie, K.
    • Journal Title

      RSC Chem. Biol.

      Volume: 3 Issue: 12 Pages: 1380-1396

    • DOI

      10.1039/d2cb00194b

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K19607, KAKENHI-PROJECT-20H03583, KAKENHI-PROJECT-20K16006, KAKENHI-PROJECT-26221202
  • [Journal Article] Natural compounds that enhance the motor function in a mouse model of muscle fatigue.2022

    • Author(s)
      Shuichi, S., Watanabe, K., Sakuraba, D., Abe, T., and Shimizu, T.
    • Journal Title

      Biomedicines

      Volume: 10 Issue: 12 Pages: 3073-3073

    • DOI

      10.3390/biomedicines10123073

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K19607, KAKENHI-PROJECT-20H03583
  • [Journal Article] Short-term resveratrol treatment restored the quality of oocytes in aging mice.2022

    • Author(s)
      Okamoto, N., Sato, Y., Kawagoe, Y., Shimizu, T., Kawamura, K.
    • Journal Title

      Aging

      Volume: 14 Issue: 14 Pages: 5628-5640

    • DOI

      10.18632/aging.204157

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K19607, KAKENHI-PROJECT-20H03583, KAKENHI-PROJECT-18K19624, KAKENHI-PROJECT-19H03801
  • [Journal Article] Acai pulp upregulates erythropoietin by inducing renal hypoxic condition in mice2022

    • Author(s)
      澁谷修一,渡辺憲史,Mario Jose Villegas Yata,清水孝彦.
    • Journal Title

      Functional Food Research

      Volume: 18 Issue: 0 Pages: 65-69

    • DOI

      10.32153/ffr.ffr18_p65-69

    • ISSN
      2432-3357, 2434-3048
    • Year and Date
      2022-09-12
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K19607, KAKENHI-PROJECT-20H03583
  • [Journal Article] Symposium25-42022

    • Author(s)
      清水孝彦
    • Journal Title

      Japanese Journal of Physical Fitness and Sports Medicine

      Volume: 71 Issue: 1 Pages: 118-118

    • DOI

      10.7600/jspfsm.71.118

    • NAID

      130008141326

    • ISSN
      0039-906X, 1881-4751
    • Language
      Japanese
    • Open Access
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Journal Article] APP Knock-In Mice Produce E22P-Aβ Exhibiting an Alzheimer’s Disease-like Phenotype with Dysregulation of Hypoxia-Inducible Factor Expression2022

    • Author(s)
      Maki Takahito、Sawahata Masahito、Akutsu Ichiro、Amaike Shohei、Hiramatsu Genki、Uta Daisuke、Izuo Naotaka、Shimizu Takahiko、Irie Kazuhiro、Kume Toshiaki
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 21 Pages: 13259-13259

    • DOI

      10.3390/ijms232113259

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09323, KAKENHI-PROJECT-22K09020, KAKENHI-PROJECT-22K19607, KAKENHI-PROJECT-20H03583, KAKENHI-PROJECT-19K07119, KAKENHI-PROJECT-20K16006, KAKENHI-PROJECT-26221202
  • [Journal Article] Development of a Novel Alzheimer's Disease Model Based on the Theory of the Toxic-conformer of Amyloid β2021

    • Author(s)
      泉尾直孝、清水孝彦、村上一馬、入江一浩
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 141 Issue: 6 Pages: 843-849

    • DOI

      10.1248/yakushi.20-00251-5

    • NAID

      130008046322

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2021-06-01
    • Language
      Japanese
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-20H03583, KAKENHI-PROJECT-20K16006
  • [Journal Article] SOD2 in skeletal muscle: New insights from an inducible deletion model.2021

    • Author(s)
      Zhuang, A., Yang, C., Liu, Y., Tan, Y., Bond, S.T., Walker, S., Sikora, T., Laskowski, A., Sharma, A., de Haan, J.B., Meikle, P.J., Shimizu, T., Coughlan, M.T., Calkin, A.C., Drew, B.G.
    • Journal Title

      Redox Biology

      Volume: 47 Pages: 102135-102135

    • DOI

      10.1016/j.redox.2021.102135

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Journal Article] Xanthine oxidoreductase-mediated superoxide production is not involved in the age-related pathologies of Sod1-deficient mice2021

    • Author(s)
      Shibuya, S., Watanabe, K., Ozawa, Y., Shimizu, T.
    • Journal Title

      Int J. Mol. Sci.

      Volume: 22 Issue: 7 Pages: 3542-3542

    • DOI

      10.3390/ijms22073542

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Journal Article] Neuron-specific mitochondrial oxidative stress results in epilepsy, glucose dysregulation and a striking astrocyte response.2021

    • Author(s)
      Fulton, R.E., Pearson-Smith, J.N., Huynh, C.Q., Fabisiak, T., Liang, L., Aivazidis, S., High, B.A., Buscaglia, G., Corrigan, T., Valdez, R., Danis, E., Shimizu, T., and Patel, M.N.
    • Journal Title

      Neurobiol. Dis.

      Volume: 158 Pages: 105470-105470

    • DOI

      10.1016/j.nbd.2021.105470

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Journal Article] 老化ストレス応答研究2021

    • Author(s)
      清水孝彦
    • Journal Title

      医学のあゆみ

      Volume: 279 Pages: 364-369

    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Journal Article] An RNA aptamer with potent affinity for a toxic dimer of amyloid β42 has potential utility for histochemical studies of Alzheimer's disease2020

    • Author(s)
      Murakami Kazuma, Obata Yayoi, Sekikawa Asa, Ueda Haruka, Awano Tatsuya, Takabe Keiji, Takahiko Shimizu, Irie Kazuhiro
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 295 Issue: 15 Pages: 4870-4880

    • DOI

      10.1074/jbc.ra119.010955

    • Description
      in press
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-16H06194, KAKENHI-PROJECT-20H03583
  • [Journal Article] SOD1 deficiency alters gastrointestinal microbiota and metabolites in mice2020

    • Author(s)
      Sagi, H., Shibuya, S., Kato, T., Nakanishi, Y., Tsuboi, A., Moriya, S., Ohno, H., Miyamoto, H., Kodama, H., Shimizu, T.
    • Journal Title

      Exp. Gerontol.

      Volume: 130 Pages: 110795-110795

    • DOI

      10.1016/j.exger.2019.110795

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Journal Article] Cerebral artery dilation during transient ischemia is impaired by mechanical barrier of amyloid β deposition around cerebral artery in Alzheimer’s disease model mice2020

    • Author(s)
      Watanabe, N., Noda, Y., Iimura, K., Shimizu, T., Hotta, H.
    • Journal Title

      J. Physiol. Sci.

      Volume: 70 Issue: 1 Pages: 57-57

    • DOI

      10.1186/s12576-020-00785-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03583, KAKENHI-PROJECT-23K20363
  • [Journal Article] 臓器老化を標的にした食品素材の機能性解析2020

    • Author(s)
      清水孝彦
    • Journal Title

      Functional Food Research

      Volume: 16 Pages: 21-27

    • NAID

      130007899889

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Journal Article] Pathological relationship between intracellular superoxide metabolism and p53 signaling in mice2020

    • Author(s)
      Watanabe, K., Shibuya, S., Ozawa, Y., Toda, T., Shimizu, T.
    • Journal Title

      Int J. Mol. Sci.

      Volume: 22 Issue: 7 Pages: 3548-3548

    • DOI

      10.3390/ijms22073548

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Journal Article] Detection of amyloid β oligomers with RNA aptamers in AppNL-G-F/NL-G-F Mice: a model of Arctic Alzheimer’s disease2020

    • Author(s)
      Obata Yayoi、*Murakami Kazuma、Kawase Taiji、Hirose Kenji、Izuo Naotaka、Shimizu Takahiko、*Irie Kazuhiro
    • Journal Title

      ACS Omega

      Volume: 5 Issue: 34 Pages: 21531-21537

    • DOI

      10.1021/acsomega.0c02134

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H06194, KAKENHI-PROJECT-20H03583, KAKENHI-PROJECT-26221202
  • [Journal Article] 加齢と骨代謝2020

    • Author(s)
      清水孝彦
    • Journal Title

      医学のあゆみ

      Volume: 273 Pages: 600-606

    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Journal Article] Acai extract transiently upregulates erythropoietin by inducing a renal hypoxic condition in mice2020

    • Author(s)
      Shibuya, S., Toda, T., Ozawa, Y., Yata, M.J.V., Shimizu, T.
    • Journal Title

      Nutrients

      Volume: 12 Issue: 2 Pages: 533-533

    • DOI

      10.3390/nu12020533

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Journal Article] The effects of 3% diquafosol sodium eye drops on tear functions and ocular surface of the Cu, Zn-superoxide dismutase-1 (Sod1) knock out mice treated with antiglaucoma eye medications2020

    • Author(s)
      Yagi-Yaguchi, Y., Kojima, T., Higa, K., Dogru, M.*, Ibrahim, O., Shimizu, T., Tsubota, K. Shimazaki, J.
    • Journal Title

      Diagnostics

      Volume: 10 Issue: 1 Pages: 20-20

    • DOI

      10.3390/diagnostics10010020

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Journal Article] マトリックスメタロプロテアーゼ(MMP)と組織老化2020

    • Author(s)
      清水孝彦
    • Journal Title

      老年内科

      Volume: 2 Pages: 638-644

    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Journal Article] SOD2 deficiency in cardiomyocytes defines defective mitochondrial bioenergetics as a cause of lethal dilated cardiomyopathy2020

    • Author(s)
      Sharma, S., Bhattarai, S., Ara, H., Sun G., St. Clair, D.K., Bhuiyan, S., Kevil, C., Watts, M.N., Dominic, P., Shimizu, T., McCarthy, K.J., Sun, H., Panchatcharam, M.
    • Journal Title

      Redox Biology

      Volume: 37 Pages: 101740-101740

    • DOI

      10.1016/j.redox.2020.101740

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Journal Article] りんごポリフェノール2020

    • Author(s)
      増田功、清水孝彦
    • Journal Title

      運動機能・認知機能改善食品の開発

      Volume: 1 Pages: 91-95

    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Journal Article] Redox-dependent PPARγ/Tnpo1 complex formation enhances PPARγ nuclear localization and signaling2020

    • Author(s)
      Teratani Toshiaki、Tomita Kengo、Toma-Fukai Sachiko、Nakamura Yutaro、Itoh Toshimasa、Shimizu Hikaru、Shiraishi Yasunaga、Sugihara Nao、Higashiyama Masaaki、Shimizu Takahiko、Inoue Ikuo、Takenaka Yasuhiro、Hokari Ryota、Adachi Takeshi、Shimizu Toshiyuki、Miura Soichiro、Kanai Takanori
    • Journal Title

      Free Radical Biology and Medicine

      Volume: 156 Pages: 45-56

    • DOI

      10.1016/j.freeradbiomed.2020.06.005

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K17204, KAKENHI-PROJECT-18H02815, KAKENHI-PROJECT-20H03583, KAKENHI-PROJECT-18K08014, KAKENHI-PROJECT-18KK0246, KAKENHI-PROJECT-18K07924
  • [Journal Article] Syringaresinol Reverses Age-Related Skin Atrophy by Suppressing FoxO3a-Mediated Matrix Metalloproteinase-2 Activation in Copper/Zinc Superoxide Dismutase-Deficient Mice2019

    • Author(s)
      Kim J, Toda T, Watanabe K, Shibuya S, Ozawa Y, Izuo N, Cho S, Seo DB, Yokote K, Shimizu T
    • Journal Title

      J Invest Dermatol

      Volume: 139 Issue: 3 Pages: 648-655

    • DOI

      10.1016/j.jid.2018.10.012

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01558, KAKENHI-PROJECT-16J05570
  • [Journal Article] R3hdml regulates satellite cell proliferation and differentiation2019

    • Author(s)
      Sakamoto Kenichi、Furuichi Yasuro、Yamamoto Masashi、Takahashi Megumi、Akimoto Yoshihiro、Ishikawa Takahiro、Shimizu Takahiko、Fujimoto Masanori、Takada‐Watanabe Aki、Hayashi Aiko、Mita Yoshitaka、Manabe Yasuko、Fujii Nobuharu L、Ishibashi Ryoichi、Maezawa Yoshiro、Betsholtz Christer、Yokote Koutaro、Takemoto Minoru
    • Journal Title

      EMBO reports

      Volume: 20 Issue: 11 Pages: 1-12

    • DOI

      10.15252/embr.201947957

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06840, KAKENHI-PROJECT-19K16942, KAKENHI-PROJECT-17H01558, KAKENHI-PROJECT-17H02159, KAKENHI-PROJECT-17K09292, KAKENHI-PROJECT-17K09687, KAKENHI-PROJECT-17K19920, KAKENHI-PROJECT-18K19751, KAKENHI-PROJECT-18H04086
  • [Journal Article] An App knock-in mouse inducing the formation of a toxic conformer of Aβ as a model for evaluating only oligomer-induced cognitive decline in Alzheimer's disease2019

    • Author(s)
      Izuo Naotaka, Murakami Kazuma, Fujihara Yoshitaka, Maeda Masahiro, Saito Takashi, Saido C. Takaomi, Irie Kazuhiro, Shimizu Takahiko
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 515 Issue: 3 Pages: 462-467

    • DOI

      10.1016/j.bbrc.2019.05.131

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Journal Article] アミロイドβ「毒性コンホマー」を標的にしたアルツハイマー病の治療・診断法の開発2018

    • Author(s)
      泉尾直孝、清水孝彦、村上一馬、入江一浩
    • Journal Title

      医薬品医療機器レギュラトリーサイエンス

      Volume: 49 Pages: 312-318

    • Data Source
      KAKENHI-PROJECT-26221202
  • [Journal Article] Apple procyanidins promote mitochondrial biogenesis and proteoglycan biosynthesis in chondrocytes.2018

    • Author(s)
      Masuda I, Koike M, Nakashima S, Mizutani Y, Ozawa Y, Watanabe K, Sawada Y, Sugiyama H, Sugimoto A, Nojiri H, Sashihara K, Yokote K, Shimizu T
    • Journal Title

      Sci Rep.

      Volume: 8 Issue: 1 Pages: 7229-7229

    • DOI

      10.1038/s41598-018-25348-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10942, KAKENHI-PROJECT-17H01558
  • [Journal Article] Change of Amyloid-β 1-42 Toxic Conformer Ratio After Cerebrospinal Fluid Diversion Predicts Long-Term Cognitive Outcome in Patients with Idiopathic Normal Pressure Hydrocephalus2018

    • Author(s)
      Akiba C, Nakajima M, Miyajima M, Ogino I, Motoi Y, Kawamura K, Adachi S, Kondo A, Sugano H, Tokuda T, Irie K, Arai H
    • Journal Title

      J Alzheimers Dis.

      Volume: 25 Issue: 3 Pages: 989-1002

    • DOI

      10.3233/jad-180059

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K10372, KAKENHI-PROJECT-17K10908, KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-18H02916
  • [Journal Article] EGCG, a green tea catechin, attenuates the progression of heart failure induced by the heart/muscle-specific deletion of MnSOD in mice.2017

    • Author(s)
      Oyama, J.*, Shirakihara, A., Nishikido, T., Maeda, T., Komoda, H., Shimizu, T., Makino, N., Node, K.
    • Journal Title

      J Cardiol.

      Volume: 69 Issue: 2 Pages: 417-427

    • DOI

      10.1016/j.jjcc.2016.05.019

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26293165, KAKENHI-PROJECT-26462283, KAKENHI-PROJECT-15K08919
  • [Journal Article] Balfour Sartor, John P Iredale, Jack Satsangi. MDR1-deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation.2017

    • Author(s)
      Gwo-Tzer Ho, Rhona E Aird, Bo Liu, Nicholas A Kennedy, David A Dorward, Colin L Noble, Takahiko Shimizu, Nicholas M Morton, Adriano G Rossi, R. Balfour Sartor, John P Iredale, Jack Satsangi.
    • Journal Title

      Mucosal Immunology

      Volume: - Issue: 1 Pages: 120-130

    • DOI

      10.1038/mi.2017.31

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293165, KAKENHI-PROJECT-26462283
  • [Journal Article] A toxic conformer of Aβ42 with a turn at 22-23 is a novel therapeutic target for Alzheimer’s disease2017

    • Author(s)
      Naotaka Izuo, Chihiro Kasahara, Kazuma Murakami, Toshiaki Kume, Masahiro Maeda, Kazuhiro Irie, Koutaro Yokote, Takahiko Shimizu
    • Journal Title

      Sci. Rep.

      Volume: 7 Issue: 1 Pages: 11811-11811

    • DOI

      10.1038/s41598-017-11671-6

    • NAID

      120006368174

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-17H01558, KAKENHI-PROJECT-15K07965, KAKENHI-PROJECT-16J05570, KAKENHI-PROJECT-15K19279
  • [Journal Article] Manganese superoxide dismutase influences the extent of noise-induced hearing loss in mice.2017

    • Author(s)
      Tuerdi A, Kinoshita M, Kamogashira T, Fujimoto C, Iwasaki S, Shimizu T, Yamasoba T
    • Journal Title

      Neurosci Lett

      Volume: 642 Pages: 123-128

    • DOI

      10.1016/j.neulet.2017.02.003

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-26111506, KAKENHI-PROJECT-26253081, KAKENHI-PROJECT-15H06174, KAKENHI-PROJECT-25293347, KAKENHI-PROJECT-26293165, KAKENHI-PROJECT-26462283, KAKENHI-PROJECT-15K10743, KAKENHI-PROJECT-15K15616
  • [Journal Article] Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42 and its application toward the Alzheimer's disease diagnosis2016

    • Author(s)
      Kazuma Murakami, Maki Tokuda, Takashi Suzuki, Yumi Irie, Mizuho Hanaki, Naotaka Izuo, Yoko Monobe, Ken-ichi Akagi, Ryotaro Ishii, Harutsugu Tatebe, Takahiko Tokuda, Masahiro Maeda, Toshiaki Kume, Takahiko Shimizu, Kazuhiro Irie
    • Journal Title

      Sci. Rep.

      Volume: 6 Issue: 1 Pages: 29038-29038

    • DOI

      10.1038/srep29038

    • NAID

      120005774689

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26221202, KAKENHI-PROJECT-26293165, KAKENHI-PROJECT-26462283, KAKENHI-PROJECT-16K14254, KAKENHI-PROJECT-15K07965, KAKENHI-PROJECT-15K09322, KAKENHI-PROJECT-15K19279, KAKENHI-PROJECT-16J05570
  • [Journal Article] Effects of Korean ginseng berry on skin anti-pigmentation and anti-aging via FoxO3a activation.2016

    • Author(s)
      Juewon Kim, Si Young Cho, Su Hwan Kim, Donghyun Cho, Sunmi Kim, Chan-Woong Park, Shimizu, T., Jae Youl Cho, Dae Bang Seo*, Song Seok Shin*.
    • Journal Title

      J. Ginseng Res.

      Volume: - Issue: 3 Pages: 277-283

    • DOI

      10.1016/j.jgr.2016.05.005

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293165, KAKENHI-PROJECT-26462283
  • [Journal Article] アルツハイマー病様神経毒性におけるアミロイドβコンホマーの役割2015

    • Author(s)
      泉尾直孝*、村上一馬、久米利明、前田雅弘、入江一浩、清水孝彦
    • Journal Title

      基礎老化研究

      Volume: 39 Pages: 29-34

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Journal Article] Brain-specific superoxide dismutase 2 deficiency causes perinatal death with spongiform encephalopathy in mice.2015

    • Author(s)
      Izuo, N., Nojiri, H., Uchiyama, S., Noda, Y., Kawakami, S., Kojima, S., Sasaki, T., Shirasawa, T., Shimizu, T.
    • Journal Title

      Oxid. Med. Cell. Longev

      Volume: 2015 Pages: 238914-238914

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26462283
  • [Journal Article] Serum soluble LR11, a novel tumor derived biomarker associated with the outcome of patients with diffuse large B-cell lymphoma.2015

    • Author(s)
      Ohwada C, Yamazaki A, Kawaguchi T, Sugita Y, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Tsukamoto S, Muto T, Jiang M, Higashi M, Yokote K, Tamaru JI, Bujo H, Nakaseko C.
    • Journal Title

      Leuk Lymphoma.

      Volume: 印刷中 Issue: 10 Pages: 1-4

    • DOI

      10.3109/10428194.2015.1016930

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24591380, KAKENHI-PROJECT-25461409, KAKENHI-PROJECT-15K15198, KAKENHI-PROJECT-15K08366, KAKENHI-PROJECT-26670362, KAKENHI-PROJECT-26293165
  • [Journal Article] Resveratrol derivative-rich melinjo seed extract attenuates skin atrophy in Sod1-deficient mice.2015

    • Author(s)
      Watanabe, K., Shibuya, S., Ozawa, Y., Izuo, N., Shimizu, T.
    • Journal Title

      Oxid. Med. Cell. Longev.

      Volume: 2015 Pages: 391075-391075

    • DOI

      10.1155/2015/391075

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26462283, KAKENHI-PROJECT-15K19279
  • [Journal Article] Magnetic resonance enterocolonography in detecting erosion and redness in intestinal mucosa of patients with Crohn's disease.2015

    • Author(s)
      Sato H, Tamura C, Narimatsu K, Shimizu M, Takajyo T, Yamashita M, Inoue Y, Ozaki H, Furuhashi H, Maruta K, Yasutake Y, Yoshikawa K, Watanabe C, Komoto S, Tomita K, Nagao S, Miura S, Shinmoto H, Hokari R
    • Journal Title

      Journal of Gastroenterology and Hepatology

      Volume: 30 Issue: 4 Pages: 667-673

    • DOI

      10.1111/jgh.12851

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K09031
  • [Journal Article] Comparison in decision-making between bulimia nervosa, anorexia nervosa, and healthy women: influence of mood status and pathological eating concerns2015

    • Author(s)
      Matsumoto J, Hirano Y, Numata N, Matsuzawa D, Murano S, Yokote K, Iyo M, Shimizu E, Nakazato M.
    • Journal Title

      J Eat Disord

      Volume: 3 Issue: 1 Pages: 14-14

    • DOI

      10.1186/s40337-015-0050-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25461749, KAKENHI-PROJECT-25461750, KAKENHI-PROJECT-15K01703, KAKENHI-PROJECT-26293165
  • [Journal Article] The effects of 2% rebapimide ophthalmic solution on the tear functions and ocular surface of the superoxide dismutase-1 (Sod1) knockout mice.2015

    • Author(s)
      Kojima, T., Dogru, M.*, Ibrahim, O. M., Wakamatsu, T. H., Ito, M., Igarashi, A., Inaba, T., Shimizu, T., Shirasawa, T. Shimazaki, J., Tsubota, K.
    • Journal Title

      Invest. Ophthalmol. Vis. Sci.

      Volume: 54 Issue: 12 Pages: 7793-7802

    • DOI

      10.1167/iovs.13-13128

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26462283
  • [Journal Article] Brain-specific superoxide dismutase 2 deficiency causes perinatal death with spongiform encephalopathy in mice.2015

    • Author(s)
      Izuo, N., Nojiri, H., Uchiyama, S., Noda, Y., Kawakami, S., Kojima, S., Sasaki, T., Shirasawa, T., Shimizu, T.
    • Journal Title

      Oxid. Med. Cell. Longev.

      Volume: 2015 Pages: 238914-238914

    • DOI

      10.1155/2015/238914

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26462283, KAKENHI-PROJECT-26462319, KAKENHI-PROJECT-15K19279
  • [Journal Article] Mitochondrial superoxide in osteocytes perturbs canalicular networks in the setting of age-related osteoporosis.2015

    • Author(s)
      Kobayashi K1, Nojiri H2, Saita Y2, Morikawa D1, Ozawa Y3, Watanabe K3, Koike M1, Asou Y4, Shirasawa T5, Yokote K6, Kaneko K2, Shimizu T3.
    • Journal Title

      Scientific Reports

      Volume: Mar 16;5 Issue: 1 Pages: 9148-9148

    • DOI

      10.1038/srep09148

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24592257, KAKENHI-PROJECT-24791568, KAKENHI-PLANNED-26115009, KAKENHI-PROJECT-26462283, KAKENHI-PROJECT-26462319, KAKENHI-PROJECT-26670362, KAKENHI-PROJECT-26293165
  • [Journal Article] Aging-induced changes in sex-steroidogenic enzymes and sex-steroid receptors in the cortex, hypothalamus and cerebellum2015

    • Author(s)
      Munetomo A, Hojo Y, Higo S, Kato A, Yoshida K, Shirasawa T, Shimizu T, Barron A, Kimoto T and Kawato S
    • Journal Title

      J Physiol. Sci

      Volume: 65 Issue: 3 Pages: 253-263

    • DOI

      10.1007/s12576-015-0363-x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26430006, KAKENHI-PROJECT-26462283, KAKENHI-PROJECT-15H06154
  • [Journal Article] Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration2015

    • Author(s)
      Koike, M., Nojiri, H., Ozawa, Y., Watanabe, K., Muramatsu, Y., Kaneko, H., Morikawa, D., Kobayashi, K., Saita, Y., Sasho, T., Shirasawa, T., Yokote, K., Kaneko, K., Shimizu, T.
    • Journal Title

      Sci. Rep.

      Volume: 5 Issue: 1 Pages: 11722-11722

    • DOI

      10.1038/srep11722

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26462283, KAKENHI-PROJECT-26462319, KAKENHI-PROJECT-26670362, KAKENHI-PROJECT-26293165
  • [Journal Article] Mitochondrial respiration deficits driven by reactive oxygen species in experimental temporal lobe epilepsy.2015

    • Author(s)
      Rowley, S., Liang, LP., Fulton, R., Shimizu, T., Day, B., Patel, M.
    • Journal Title

      Neurobiol. Dis.

      Volume: 75 Pages: 151-158

    • DOI

      10.1016/j.nbd.2014.12.025

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462283
  • [Journal Article] Superoxide dismutase 1 loss disturbs intracellular redox signaling, resulting in global age-related pathological changes.2014

    • Author(s)
      Watanabe, K., Shibuya, S., Ozawa, Y., Nojiri, H., Izuo, N., Yokote, K., and Shimizu, T.
    • Journal Title

      BioMed. Res. Int.

      Volume: 2014 Pages: 140165-140165

    • DOI

      10.1155/2014/140165

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26462283
  • [Journal Article] Sod1 loss induces intrinsic superoxide accumulation leading to p53-mediated growth arrest and apoptosis.2013

    • Author(s)
      Watanabe K, Shibuya S, Koyama H, Ozawa Y, Toda T, Yokote K, Shimizu T.
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 14(6) Issue: 6 Pages: 10998-11010

    • DOI

      10.3390/ijms140610998

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390185, KAKENHI-PROJECT-24659346
  • [Journal Article] Cytoplasmic reactive oxygen species and SOD1 regulate bone mass during mechanical unloading.2013

    • Author(s)
      Morikawa D, Nojiri H, Saita Y, Kobayashi K, Watanabe K, Ozawa Y, Koike M, Asou Y, Takaku T, Kaneko K, Shimizu T.
    • Journal Title

      J Bone Miner Res

      Volume: november 28(11) Issue: 11 Pages: 2368-80

    • DOI

      10.1002/jbmr.1981

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592257, KAKENHI-PROJECT-24791568
  • [Journal Article] Non-toxic conformer of Aβ42 may suppress Aβ42-induced toxicity in rat primary neurons : implications for the novel therapeutic strategy of Alzheimer's disease2013

    • Author(s)
      Izuo, N., Murakami, K., (他3名), Shimizu, T., Akaike, A., Irie, K., Kume, T
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 438 Issue: 1 Pages: 1-5

    • DOI

      10.1016/j.bbrc.2013.05.106

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21248015, KAKENHI-PROJECT-24390139, KAKENHI-PROJECT-24590111, KAKENHI-PROJECT-25460095, KAKENHI-PROJECT-25670036
  • [Journal Article] 骨細胞における抗酸化酵素Sod2の骨リモデリング制御機構2013

    • Author(s)
      小林 慶司, 野尻 英俊, 齋田 良知, 森川 大智, 小池 正人, 麻生 義則, 金子 和夫, 清水 孝彦
    • Journal Title

      日本整形外科学会雑誌

      Volume: 87巻8号

    • Data Source
      KAKENHI-PROJECT-24791568
  • [Journal Article] LR11 : a novel biomarker identified in follicular lymphoma2013

    • Author(s)
      Kawaguchi T, Ohwada C, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Sakai S, Tsukamoto S, Yamazaki A, Sugita Y, Jiang M, Higashi M, Yokote K, Tamura J, Bujo H, Nakaseko C
    • Journal Title

      Br J Haematol

      Volume: 163(2) Issue: 2 Pages: 277-280

    • DOI

      10.1111/bjh.12467

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390185, KAKENHI-PROJECT-23590413, KAKENHI-PROJECT-24390231, KAKENHI-PROJECT-24591380, KAKENHI-PROJECT-24659346, KAKENHI-PROJECT-24790907, KAKENHI-PROJECT-25461409
  • [Journal Article] 骨細胞特異的Sod2欠損マウスにおける骨リモデリング制御機構の解析2013

    • Author(s)
      小林 慶司, 野尻 英俊, 齋田 良知, 森川 大智, 小池 正人, 麻生 義則, 金子 和夫, 清水 孝彦
    • Journal Title

      日本骨代謝学会学術集会プログラム抄録集

      Volume: 31 Pages: 77-77

    • Data Source
      KAKENHI-PROJECT-24791568
  • [Journal Article] Reversal of slow growth and heartbeat through restoration of mitochondrial functions in clk-1-deficient mouse embryos by exogenous administration of coenzyme Q10.2012

    • Author(s)
      1. Takahashi, M., Shimizu, T., Shirasawa, T.
    • Journal Title

      Exp. Gerontol.

      Volume: 47 Issue: 6 Pages: 425-431

    • DOI

      10.1016/j.exger.2012.03.008

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23617042
  • [Journal Article] Factors associated with the efficiency of PBSC collection in POEMS syndrome patients undergoing autologous PBSC transplantation.2012

    • Author(s)
      Shimizu N
    • Journal Title

      Bone Marrow Transplantation

      Volume: 47 Pages: 1010-1012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659346
  • [Journal Article] Mobilization of PBSCs in poor mobilizers with POEMS syndrome using G-CSF with plerixafor.2012

    • Author(s)
      Shimizu N
    • Journal Title

      Bone Marrow Transplant

      Volume: 47(12) Pages: 1587-1588

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659346
  • [Journal Article] CuZn-SOD 欠損は低骨代謝回転型骨量減少と加齢性コラーゲン架橋変化を引き起こし骨脆弱化する2012

    • Author(s)
      清水 孝彦, 野尻 英俊
    • Journal Title

      Biomedical Research on Trace Elements

      Volume: 23巻1号 Pages: 1-5

    • NAID

      10030755992

    • Data Source
      KAKENHI-PROJECT-24791568
  • [Journal Article] Restoration of the behavioral rates and lifespan in clk-1 mutant nematodes in response to exogenous CoQ10.2012

    • Author(s)
      Takahashi, M., Ogawara, M., Shimizu, T., Shirasawa, T.
    • Journal Title

      Exp. Gerontol

      Volume: 47 Pages: 276-279

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23617042
  • [Journal Article] Pharmaceutical Effect of Manganese Porphyrins on Manganese Superoxide Dismutase Deficient Mice2012

    • Author(s)
      N. Hayakawa, S. Asayama, Y. Noda, ShimizuT. ShimizuT., H. Kawakami
    • Journal Title

      Mol. Pharmaceutics

      Volume: 9 Issue: 10 Pages: 2956-2959

    • DOI

      10.1021/mp300147v

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22300166, KAKENHI-PROJECT-24650281
  • [Journal Article] Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation2012

    • Author(s)
      Kulic, L., (他10名), Shimizu, T., Murakami, K., Irie, K., (他4名)
    • Journal Title

      Transl. Psychiatry

      Volume: 2 Issue: 11 Pages: e183-e183

    • DOI

      10.1038/tp.2012.109

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Journal Article] Stimulation of the Amyloidogenic Pathway by Cytoplasmic Superoxide Radicals in an Alzheimer's Disease Mouse Model2012

    • Author(s)
      Murakami, K., Murata, N., Noda, Y., Irie, K., Shirasawa, T., Shimizu, T
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 76 Issue: 6 Pages: 1098-1103

    • DOI

      10.1271/bbb.110934

    • NAID

      10030817824

    • ISSN
      0916-8451, 1347-6947
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21248015, KAKENHI-PROJECT-22603006
  • [Journal Article] Formation of the 42-mer amyloid β radical and the therapeutic role of superoxide dismutase in Alzheimer's disease.2011

    • Author(s)
      Murakami, K., Shimizu, T. Irie, K.
    • Journal Title

      J Amino Acid 2011

      Pages: 654207-654207

    • Data Source
      KAKENHI-PROJECT-20500641
  • [Journal Article] Superoxide dismutase deficiency enhances superoxide levels in brain tissues during oxygenation and hypoxia-reoxygenation.2011

    • Author(s)
      Sasaki T., Shimizu T., Koyama T., Sakai M., Uchiyama S., Kawakami S., Noda Y., Shirasawa T., Kojima S.
    • Journal Title

      J Neurosci Res 89

      Pages: 601-610

    • Data Source
      KAKENHI-PROJECT-20390085
  • [Journal Article] MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle atrophy during aging.2011

    • Author(s)
      Lustgarten, M.S., Jang, Y.C., Liu, Y., Qi, W., Qin, Y., Dahia, P.L., Shi, Y., Bhattacharya, A., Muller, F.L., Shimizu, T., Shirasawa, T., Richardson, A. Van Remmen, H.
    • Journal Title

      Aging Cell 10

      Pages: 493-505

    • Data Source
      KAKENHI-PROJECT-20500641
  • [Journal Article] Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice.2011

    • Author(s)
      Shimizu T, et al.
    • Journal Title

      Biochem Biophys Res Commun (in press.)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590796
  • [Journal Article] SOD1 (cupper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer's disease2011

    • Author(s)
      Murakami, K., (他8名), Irie, K., Shirasawa, T., Shimizu, T
    • Journal Title

      J. Biol. Chem

      Volume: 286 Issue: 52 Pages: 44557-44568

    • DOI

      10.1074/jbc.m111.279208

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21248015, KAKENHI-PROJECT-22300118, KAKENHI-PROJECT-22603006
  • [Journal Article] Antioxidant therapy attenuates myocardial telomerase activity reduction in superoxide dismutase-deficient mice.2011

    • Author(s)
      Makino, N., Maeda, T., Oyama, J.I., Sasaki, M., Higuchi, Y., Mimori, K. Shimizu, T.
    • Journal Title

      J Mol Cell Cardiol 50

      Pages: 670-677

    • NAID

      120004951631

    • Data Source
      KAKENHI-PROJECT-20500641
  • [Journal Article] Superoxide dismutase deficiency enhances superoxide levels in brain tissues during oxygenation and hypoxia-reoxygenation.2011

    • Author(s)
      Sasaki, T., Shimizu, T., Koyama, T., Sakai, M., Uchiyama, S., Kawakami, S., Noda, Y., Shirasawa, T., Kojima, S.
    • Journal Title

      J Neurosci Res 89

      Pages: 601-610

    • Data Source
      KAKENHI-PROJECT-20500641
  • [Journal Article] Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 232010

    • Author(s)
      Murakami, K., (他8名), Shimizu, T., Irie, K
    • Journal Title

      ACS Chem. Neurosci

      Volume: 1 Issue: 11 Pages: 747-756

    • DOI

      10.1021/cn100072e

    • NAID

      130004504903

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Journal Article]2010

    • Author(s)
      清水孝彦, ら
    • Journal Title

      新老年学「第3版」(東京大学出版社)

      Pages: 213-236

    • Data Source
      KAKENHI-PROJECT-20500641
  • [Journal Article] Oxidative stress in skeletal muscle causes severe disturbance of exercise activity without muscle atrophy.2010

    • Author(s)
      Kuwahara H., Horie T. Ishikawa S. Tsuda C., Kawakami S., Noda Y., Kaneko T., Tahara S., Tachibana T., Okabe M., Melki J., Takano R., Toda T., Morikawa D., Nojiri H., Kurosawa H., Shirasawa T., Shimizu T.
    • Journal Title

      Free Rad Biol Med 48

      Pages: 1252-1262

    • Data Source
      KAKENHI-PROJECT-20390085
  • [Journal Article] Silymarin Attenuated the Amyloid .BETA. Plaque Burden and Improved Behavioral Abnormalities in an Alzheimer's Disease Mouse Model2010

    • Author(s)
      Murata, N., Murakami, K., Ozawa, Y., Kinoshita, N., Irie, K., Shirasawa, T., Shimizu T
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 74 Issue: 11 Pages: 2299-2306

    • DOI

      10.1271/bbb.100524

    • NAID

      10027561730

    • ISSN
      0916-8451, 1347-6947
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Journal Article]2010

    • Author(s)
      清水孝彦, 他
    • Journal Title

      新老年学「第3版」(東京大学出版会)

      Pages: 213-236

    • Data Source
      KAKENHI-PROJECT-20390085
  • [Journal Article] Oxidative stress in skeletal muscle causes severe disturbance of exercise activity without muscle atrophy.2010

    • Author(s)
      Kuwahara, H., Horie, T. Ishikawa, S. Tsuda, C., Kawakami, S., Noda, Y., Kaneko, T., Tahara, S., Tachibana, T., Okabe, M., Melki, J., Takano, R., Toda, T., Morikawa, D., Nojiri, H., Kurosawa, H., Shirasawa, T., Shimizu, T.
    • Journal Title

      Free Rad Biol Med 48

      Pages: 1252-1262

    • Data Source
      KAKENHI-PROJECT-20500641
  • [Journal Article] Model mice for tissue-specific deletion of the manganese superoxide dismutase (Mn-SOD) gene.2010

    • Author(s)
      Shimizu T., Kawakami S., Nojiri N., Shirasawa T.
    • Journal Title

      Geriatr Gerontol Int 10

    • NAID

      40005949431

    • Data Source
      KAKENHI-PROJECT-20390085
  • [Journal Article] Oxidative stress in skeletal muscle causes severe disturbance of exercise activity without muscle atrophy.2010

    • Author(s)
      Shimizu T, et al.
    • Journal Title

      Free Radic Biol Med 48

      Pages: 1252-1262

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590796
  • [Journal Article] Model mice for tissue-specific deletion of the manganese superoxide dismutase (Mn-SOD) gene.2010

    • Author(s)
      Shimizu, T., Kawakami, S., Nojiri, N., Shirasawa, T.
    • Journal Title

      Geriatr Gerontol Int 10

      Pages: 70-79

    • NAID

      40005949431

    • Data Source
      KAKENHI-PROJECT-20500641
  • [Journal Article] The turn formation at positions 22 and 23 in the 42-mer amyloid beta peptide : the emerging role in the pathogenesis of Alzheimer's disease2010

    • Author(s)
      Murakami, K., Masuda, Y., Shirasawa, T., Shimizu, T., Irie, K
    • Journal Title

      Geriatr. Gerontol. Int

      Volume: 10 Issue: s1

    • DOI

      10.1111/j.1447-0594.2010.00598.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Journal Article] Identification of Physiological and Toxic Conformations in Aβ42 Aggregates2009

    • Author(s)
      Y. Masuda,(他3名) K. Takegoshi, T. Shimizu, T. Shirasawa, K. Irie
    • Journal Title

      ChemBioChem 10

      Pages: 287-295

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18208011
  • [Journal Article] Identification of physiological and toxic conformations in Aβ42 aggregates2009

    • Author(s)
      Y. Masuda, 他3名, 2-4番目, K. Takegoshi, T. Shimizu, T. Shirasawa, *K. Irie
    • Journal Title

      ChemBioChem 10

      Pages: 287-295

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18208011
  • [Journal Article] Skin atrophy in cytoplasmic SOD-deficient mice and its complete recovery using a vitamin C derivative.2009

    • Author(s)
      Murakami K., Inagaki J., Saito M., Ikeda Y., Tsuda C., Noda Y., Kawakami S., Shirasawa T., Shimizu T.
    • Journal Title

      Biochem Biophys Res Commun 382

      Pages: 457-61

    • Data Source
      KAKENHI-PROJECT-20390085
  • [Journal Article] Conditional knockout of Mn-SOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity.2009

    • Author(s)
      Shimizu T, et al.
    • Journal Title

      Am J Physiol Cell Physiol 297

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590796
  • [Journal Article] Antioxidant, EUK-8, prevents murine dilated cardiomyopathy.2009

    • Author(s)
      Kawakami, S., Matsuda, A., Sunagawa, T., Noda, Y., Kaneko, T., Tahara, S., Hiraumi, Y., Adachi, S., Matsui, H., Ando, K., Fujita, T., Maruyama, N., Shirasawa, T., Shimizu, T.
    • Journal Title

      Cir J 73

      Pages: 2125-2134

    • NAID

      10025937556

    • Data Source
      KAKENHI-PROJECT-20500641
  • [Journal Article] Skin atrophy in cytoplasmic SOD-deficient mice and its complete recovery using a vitamin C derivative.2009

    • Author(s)
      Shimizu T, et al.
    • Journal Title

      Biochem Biophys Res Commun 382

      Pages: 457-461

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590796
  • [Journal Article] Skin atrophy in cytoplasmic SOD-deficient mice and its complete recovery using a vitamin Cderivative.2009

    • Author(s)
      Murakami, K., Inagaki, J., Saito, M., Ikeda, Y., Tsuda, C., Noda, Y., Kawakami, S., Shirasawa, T., Shimizu, T.
    • Journal Title

      Biochem Biophys Res Commun 382

      Pages: 457-61

    • Data Source
      KAKENHI-PROJECT-20500641
  • [Journal Article] Conditional knockout of MnSOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity.2009

    • Author(s)
      Lustgarten, M., Jang, Y., Liu, Y., Muller, F., Qi, W., Steinhelper, M., Brooks, S., Larkin, L. M., Shimizu, T., Shirasawa, T., McManus, L., Bhattacharya, A., Richardson, A., Van Remmen, H.
    • Journal Title

      Am J Physiol 297

      Pages: 1520-1532

    • Data Source
      KAKENHI-PROJECT-20500641
  • [Journal Article] Conditional knockout of MnSOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity.2009

    • Author(s)
      Lustgarten M., Jang Y., Liu Y., Muller F., Qi W., Steinhelper M., Brooks S., Larkin L. M., Shimizu T., Shirasawa T., McManus L., Bhattacharya A., Richardson A., Van Remmen H.
    • Journal Title

      Am J Physiol 297

    • Data Source
      KAKENHI-PROJECT-20390085
  • [Journal Article] Antioxidant, EUK-8, prevents murine dilated cardiomyopathy.2009

    • Author(s)
      Kawakami S., Matsuda A., Sunagawa T., Noda Y., Kaneko T., Tahara S., Hiraumi Y., Adachi S., Matsui H., Ando K., Fujita T., Maruyama N., Shirasawa T., Shimizu T.
    • Journal Title

      Cir J 73

      Pages: 2125-2134

    • NAID

      10025937556

    • Data Source
      KAKENHI-PROJECT-20390085
  • [Journal Article] Isomerization and/or racemization at Asp23 of Aβ42 do not increase its aggregative ability, neurotoxicity, and radical productivity in vitro2008

    • Author(s)
      K. Murakami, M. Uno, Y. Masuda, T. Shimizu, T. Shirasawa, *K. Irie,
    • Journal Title

      Biochem. Biophys. Res. Commun. 366

      Pages: 745-751

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18208011
  • [Journal Article] Retinal dysfunction and progressive retinal cell death in SOD1-deficient mice.2008

    • Author(s)
      Hashizume K., Hirasawa M., Imamura Y., Noda S., Shimizu T., Shinoda K., Kurihara T., Noda K., Ozawa Y., Ishida S., Miyake Y., Shirasawa T., Tsubota K.
    • Journal Title

      Am J Pathol 172

      Pages: 1325-1331

    • Data Source
      KAKENHI-PROJECT-20390085
  • [Journal Article] Retinal dysfunction and progressive retinal cell death in SOD1-deficient mice.2008

    • Author(s)
      Shimizu T, et al.
    • Journal Title

      Am J Pathol 129

      Pages: 291-298

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590796
  • [Journal Article] Verification of the C-terminal intramolecular β-sheet in Aβ42 aggregates using solid-state NMR2008

    • Author(s)
      Y. Masuda, 他3名, 2-4番目, K. Takegoshi, T. Shimizu, T. Shirasawa, *K. Irie
    • Journal Title

      Bioorg. Med. Chem. Lett. 18

      Pages: 3206-3210

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18208011
  • [Journal Article]2008

    • Author(s)
      清水孝彦, ら
    • Journal Title

      老化・老年病のための動物実験ガイドブック(アドスリー)

      Pages: 115-122

    • Data Source
      KAKENHI-PROJECT-20500641
  • [Journal Article] アミロイドβ (Aβ42) の毒性コンホメーションの提唱2008

    • Author(s)
      *村上一馬, 清水孝彦, 白澤卓二, 入江一浩
    • Journal Title

      基礎老化研究 32

      Pages: 25-29

    • NAID

      10024377833

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18208011
  • [Journal Article] Verification of the intermolecular parallel β-sheet in E22K-Aβ42 aggregates by solid-state NMR using rotational resonance : implications for the supramolecular arrangement of the toxic conformer of Aβ422008

    • Author(s)
      Y. Masuda, 他2名, 2-3番目, K. Takegoshi, T. Shimizu, T. Shirasawa, *K. Irie
    • Journal Title

      Biosci. Biotechnol. Biochem. 72

      Pages: 2170-2175

    • NAID

      10027531218

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18208011
  • [Journal Article] Clk-1 deficiency induces apoptosis associated with mitochondrial dysfunction in mouse embryos.2008

    • Author(s)
      Takahashi, M., Shimizu, T., Moriizumi, E. Shirasawa, T.
    • Journal Title

      Mech Ageing Dev 129

      Pages: 291-298

    • Data Source
      KAKENHI-PROJECT-20500641
  • [Journal Article] Verification of the Intermolecular Parallel 13-sheet in E22K-Aβ42 Aggregates by Solid-state NMR Using Rotational Resonance : Implications for the Supramolecular Arrangement of the Toxic Conformer of Aβ42. Biosci.2008

    • Author(s)
      Y. Masuda,(他3名),K. Takegoshi, T. Shimizu, T. Shirasawa, K. Irie
    • Journal Title

      Biotechnol. Biochem 72

      Pages: 2170-2175

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18208011
  • [Journal Article] Retinal dysfunction and progressive retinal cell death in SOD1-deficient mice.2008

    • Author(s)
      Hashizume, K., Hirasawa, M., Imamura, Y., Noda, S., Shimizu, T., Shinoda, K., Kurihara, T., Noda, K., Ozawa, Y., Ishida, S., Miyake, Y., Shirasawa, T., Tsubota, K.
    • Journal Title

      Am J Pathol 172

      Pages: 1325-1331

    • Data Source
      KAKENHI-PROJECT-20500641
  • [Journal Article] Clk-1 deficiency induces apoptosis associated with mitochondrial dysfunction in mouse embryos.2008

    • Author(s)
      Takahashi M., Shimizu T., Moriizumi E., Shirasawa T.
    • Journal Title

      Mech Ageing Dev 129

      Pages: 291-298

    • Data Source
      KAKENHI-PROJECT-20390085
  • [Journal Article] The Toxic Conformation of the 42-residue Amyloid β Peptide and Its Relevance to Oxidative Stress in Alzheimer's Disease.2007

    • Author(s)
      K. Irie., K. Murakami,(他5名) K. Takegoshi, H. Fukuda, M. Nagao, T. Shimizu, T. Shirasawa
    • Journal Title

      Mini-Rev. Med. Chem 7

      Pages: 1001-1008

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18208011
  • [Journal Article] The toxic conformation of the 42-residue amyloid β peptide and its relevance to oxidative stress in Alzheimer's disease2007

    • Author(s)
      *K. Irie., K. Murakami, 他5名, 3-7番目, K. Takeoshi, H. Fukuda, M. Nagao, T. Shimizu, T. Shirasawa
    • Journal Title

      Mini-Rev. Med. Chem. 7

      Pages: 1001-1008

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18208011
  • [Journal Article] Detection of amyloid beta peptides with L-isoaspartate in Alzheimer's disease2006

    • Author(s)
      Takahiko Shimizu
    • Journal Title

      Nova Biomedical Books

      Pages: 369-374

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390085
  • [Journal Article] Verification of the turn at positions 22 and 23 of the β-amyloid fibrils using solid-state NMR : implication for the pathogenesis of Alzheimer's disease.2005

    • Author(s)
      Y.Masuda, K.Irie, K.Murakami, H.Ohigashi, R.Ohashi, K.Takegoshi, T.Shimizu, T.Shirasawa
    • Journal Title

      Bioorg.Med.Chem. 13(24)

      Pages: 6803-6809

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16380080
  • [Journal Article] Structure of β-amyloid fibrils and its relevance to their neurotoxicity : implications for the pathogenesis of Alzheimer's disease.2005

    • Author(s)
      K.Irie, K.Murakami, Y.Masuda, A.Morimoto, H.Ohigashi, R.Ohashi, K.Takegoshi, M.Nagao, T.Shimizu, T.Shirasawa
    • Journal Title

      J.Biosci.Bioeng. 99(55)

      Pages: 437-447

    • NAID

      110002695685

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16380080
  • [Journal Article] New aggregation model of amyloid β by the systematic proline replacement.2005

    • Author(s)
      K.Murakami, K.Irie, A.Morimoto, Y.Masuda, H.Ohigashi, M.Nagao, H.Fukuda, T.Shimizu, T.Shirasawa
    • Journal Title

      In Peptide Science 2004, Shimohigashi, Y.(Ed.), The Japanese Peptide Society, Fukuoka, Japan

      Pages: 179-182

    • NAID

      10014459824

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16380080
  • [Journal Article] Formation and stabilization model of the 42-mer Aβ radical : implications for the long-lasting oxidative stress in Alzheimer's disease.2005

    • Author(s)
      K.Murakami, K.Irie, H.Ohigashi, H.Hara, M.Nagao, T.Shimizu, T.Shirasawa
    • Journal Title

      J.Am.Chem.Soc. 127(43)

      Pages: 15168-15174

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16380080
  • [Journal Article] Biological significance of isoasparate and its repair system2005

    • Author(s)
      Takahiko Shimizu
    • Journal Title

      Biol Pharm Bul 28・9

      Pages: 1590-1596

    • Data Source
      KAKENHI-PROJECT-17790201
  • [Journal Article] Biological significance of isoaspartate and its repair system2005

    • Author(s)
      Takahiko Shimizu
    • Journal Title

      Biological and Pharmaceutical Bulletin 28・9

      Pages: 1590-1596

    • NAID

      110003666473

    • Data Source
      KAKENHI-PROJECT-17025051
  • [Journal Article] Biological significance of isoaspartate and its repair system2005

    • Author(s)
      Takahiko Shimizu
    • Journal Title

      Biol Pharm Bul 28・9

      Pages: 1590-1596

    • NAID

      110003666473

    • Data Source
      KAKENHI-PROJECT-17390085
  • [Journal Article] Analysis of the secondary structure of β-amyloid (Aβ42) fibrils by systematic proline replacement.2004

    • Author(s)
      A.Morimoto, K.Irie, K.Murakami, Y.Masuda, H.Ohigashi, M.Nagao, H.Fukuda, T.Shimizu, T.Shirasawa
    • Journal Title

      J.Biol.Chem. 279(50)

      Pages: 52781-52788

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16380080
  • [Patent] アミロイドβの22位及び23位のターン構造を極めて特異的に認識する抗体(学内整理番号:4718)2015

    • Inventor(s)
      入江一浩,村上一馬,清水孝彦,泉尾直孝,清藤 勉
    • Industrial Property Rights Holder
      入江一浩,村上一馬,清水孝彦,泉尾直孝,清藤 勉
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-12-14
    • Overseas
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Patent] アミロイドβの22位及び23位のターン構造を極めて特異的に認識する抗体2014

    • Inventor(s)
      入江一浩,村上一馬,清水孝彦,泉尾直孝,清藤 勉
    • Industrial Property Rights Holder
      入江一浩,村上一馬,清水孝彦,泉尾直孝,清藤 勉
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-251898
    • Filing Date
      2014-12-12
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Patent] アミロイド β のターン構造を認識する抗体2011

    • Inventor(s)
      入江一浩, 村上一馬, 増田裕一, 清水孝彦,白 澤卓二, 清藤 勉
    • Industrial Property Rights Holder
      入江一浩, 村上一馬, 増田裕一, 清水孝彦,白 澤卓二, 清藤 勉
    • Industrial Property Rights Type
      特許
    • Filing Date
      2011-04-21
    • Overseas
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Patent] Antibody recognizing tumstructure in amyloid β2010

    • Inventor(s)
      Kazuhiro Irie, Kazuma Murakami, Yuichi Masuda, Takahiko Shimizu, Takuji Shirasawa, Tsutomu Seito
    • Industrial Property Rights Holder
      Kazuhiro Irie, Kazuma Murakami, Yuichi Masuda, Takahiko Shimizu, Takuji Shirasawa, Tsutomu Seito
    • Industrial Property Rights Type
      特許
    • Filing Date
      2010-10-18
    • Acquisition Date
      2014-04-29
    • Overseas
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Patent] βアミロイド,及びそれを用いたアルツハイマ-病治療薬又は予防薬のスクリ-ニング方法2005

    • Inventor(s)
      入江一浩, 村上一馬, 大東肇, 永尾雅哉, 白澤卓二, 清水孝彦
    • Industrial Property Rights Holder
      入江一浩, 村上一馬, 大東肇, 永尾雅哉, 白澤卓二, 清水孝彦
    • Patent Publication Number
      2006-265189
    • Filing Date
      2005-03-24
    • Data Source
      KAKENHI-PROJECT-18208011
  • [Patent] βアミロイド, 及びそれを用いたアルツハイマー病治療薬又は予防薬のスクリーニング方法2005

    • Inventor(s)
      入江一浩, 村上一馬, 大東肇, 永尾雅哉, 白澤卓二, 清水孝彦
    • Industrial Property Rights Holder
      入江一浩, 村上一馬, 大東肇, 永尾雅哉, 白澤卓二, 清水孝彦
    • Patent Publication Number
      2006-265189
    • Filing Date
      2005-03-24
    • Data Source
      KAKENHI-PROJECT-18208011
  • [Presentation] Mitochondrial stress response in osteocytes regulates nuclear structure and bone metabolism via ATF4-lamins-sclerostin axis in aged bone2024

    • Author(s)
      Takahiko Shimizu, Kenji Watanabe, Shuichi Shibuya
    • Organizer
      SAGL First Anniversary International Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] ファンクショナルフードの未来2024

    • Author(s)
      清水孝彦
    • Organizer
      第20回ファンクショナルフード学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] Superoxide Dismutase 2 Deficiency Accelerates Age-related Spontaneous Intervertebral Disc Degeneration In Mice2024

    • Author(s)
      Shota Tamagawa, Daisuke Sakai, Hidetoshi Nojiri, Takayuki Warita, Jordy Schol, Takahiko Shimizu, Masato Sato, Muneaki Ishijima, Masahiko Watanabe
    • Organizer
      Orthopaedic Research Society (ORS) 2024 Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] SOD1欠損マウスを用いた健康食品の抗老化作用の評価2024

    • Author(s)
      桜庭大樹、澁谷修一、渡辺憲史、阿部卓哉、大平はる香、山本貴司、永田岳史、山口芳正、清水孝彦
    • Organizer
      第20回ファンクショナルフード学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] 細胞外マトリックス制御による老化様皮膚病態の改善作用2024

    • Author(s)
      澁谷修一、上條真弘、渡辺憲史、清水孝彦
    • Organizer
      第20回ファンクショナルフード学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] 澁谷修一、上條真弘、渡辺憲史、清水孝彦2024

    • Author(s)
      澁谷修一、上條真弘、渡辺憲史、清水孝彦
    • Organizer
      日本農芸化学会2024年度大会
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] 老化ストレスによる運動器老化の機構解明研究2024

    • Author(s)
      清水孝彦
    • Organizer
      第24回GSRCセミナー
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] アサイー果実抽出物は腎低酸素化を介して造血因子erythropoietin を増加する2023

    • Author(s)
      澁谷修一、上條真弘、渡辺憲史、Mario Jose Villegas Yata、清水孝彦
    • Organizer
      日本農芸化学会2023年度大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] 筋疲労モデルマウスの運動機能を改善する機能性食品素材2023

    • Author(s)
      澁谷修一、渡辺憲史、桜庭大樹、阿部卓哉、清水孝彦
    • Organizer
      第19回ファンクショナルフード学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] 老化ストレス制御によるアンチエイジング食品の開発2023

    • Author(s)
      清水孝彦
    • Organizer
      食品開発展2023
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] 骨細胞老化における統合的ストレス応答の寄与2023

    • Author(s)
      清水孝彦、渡辺憲史
    • Organizer
      第23回日本抗加齢医学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] 臓器老化モデルマウスを用いたファンクショナルフードの機能性解析2023

    • Author(s)
      清水孝彦
    • Organizer
      第19回ファンクショナルフード学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] インスリン抵抗性はアルツハイマー病モデルマウスにおいてアセチルコリン神経系異常を伴って早期の認知機能障害を引き起こす2023

    • Author(s)
      "泉尾 直孝、渡辺 信博、野田 義博、斉藤 貴志、西道 隆臣、横手 幸太郎、堀田 晴美、清水 孝彦 "
    • Organizer
      第76回日本自律神経学会総会
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] 臓器老化モデルマウスを用いたファンクショナルフードの機能性解析2023

    • Author(s)
      清水孝彦
    • Organizer
      第19回ファンクショナルフード学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] Wrn and Recql5 deletions promote adipose senescence and dyslipidemia2023

    • Author(s)
      Shuichi Shibuya, Kenji Watanabe, Takahiko Shimizu
    • Organizer
      IAGG Asia/Oceania Regional Congress 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] 筋疲労モデルマウスの運動機能を改善する機能性食品素材2023

    • Author(s)
      澁谷修一、渡辺憲史、桜庭大樹、阿部卓哉、清水孝彦
    • Organizer
      第19回ファンクショナルフード学会学術集会
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] 核型トランスグルタミナーゼによるイトマキヒトデ胚・幼生のヒストン共有結合性二量化2023

    • Author(s)
      池上 晋、清水孝彦、中堅三弥子、金子洋之
    • Organizer
      日本動物学会 第94回大会
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] 骨細胞老化と核ラミナ構造変化2023

    • Author(s)
      清水孝彦、渡辺憲史、澁谷修一
    • Organizer
      第96回日本生化学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] アンチエイジングの基礎2023

    • Author(s)
      清水孝彦
    • Organizer
      第64回日本卵子学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] 老化ストレスによる運動器老化の機構解明研究2023

    • Author(s)
      清水孝彦
    • Organizer
      第14回GSRCセミナー
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] 低栄養マーカーを改善する機能性物質の解析2023

    • Author(s)
      澁谷修一、清水孝彦
    • Organizer
      第8回NCGGサマーセミナー
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] アサイー果実抽出物は腎低酸素化を介して造血因子erythropoietin を増加する2023

    • Author(s)
      澁谷修一、上條真弘、渡辺憲史、Mario Jose Villegas Yata、清水孝彦
    • Organizer
      日本農芸化学会2023年度大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] Integrated stress response caused by mitochondrial dysfunction induce age-related bone loss through nuclear deformation in osteocytes2023

    • Author(s)
      Kenji Watanabe, Shuichi Shibuya, Hidetoshi Nojiri, Takahiko Shimizu
    • Organizer
      IAGG Asia/Oceania Regional Congress 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] 速筋ミトコンドリアROSは可逆的にグリコーゲン代謝及び運動機能を調節する2023

    • Author(s)
      澁谷修一、坂本一晃、渡辺憲史、野尻英俊、清水孝彦
    • Organizer
      第9回骨格筋生物学研究会
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] Influence of amyloid β deposition around the pial artery on cerebral artery response during transient ischemia in Alzheimer’s disease model mice2023

    • Author(s)
      Nobuhiro Watanabe, Yoshihiro Noda, Taeko Nemoto, Kaori Iimura, Takahiko Shimizu, Harumi Hotta
    • Organizer
      Neurovascular Unit Conference 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] 運動器疾患のジェロサイエンス研究2023

    • Author(s)
      清水孝彦、渡辺憲史、澁谷修一
    • Organizer
      第46回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] Mitochondria stress response induced ATF4 activation associated with nuclear deformation resulted in age-related bone loss2023

    • Author(s)
      渡辺憲史、澁谷修一、野尻英俊、清水孝彦
    • Organizer
      第46回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] 老化ストレスによる運動器老化の機構解明研究2023

    • Author(s)
      清水孝彦
    • Organizer
      第14回GSRCセミナー
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] Acai berry, the Brazilian Amazon palm plant, transiently upregulates erythropoietin by inducing a renal hypoxic condition in mice2023

    • Author(s)
      Takahiko Shimizu, Shuichi Shibuya, Kenji Watanabe, Mario Jose Villegas Yata
    • Organizer
      IAGG Asia/Oceania Regional Congress 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] 新規ウェルナー早老症モデルマウスの老化病態解析2023

    • Author(s)
      澁谷修一、渡辺憲史、清水孝彦
    • Organizer
      第31回日本医学会総会
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] Regulation of MMP2 restores aging-related skin atrophy induced by SOD1 deficiency2023

    • Author(s)
      澁谷修一、上條真弘、渡辺憲史、清水孝彦
    • Organizer
      第46回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] 速筋ミトコンドリアROSは可逆的にグリコーゲン代謝及び運動機能を調節する2023

    • Author(s)
      澁谷修一、坂本一晃、渡辺憲史、野尻英俊、清水孝彦
    • Organizer
      第9回骨格筋生物学研究会
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] 青ジソに含まれるアミロイドbeta42のオリゴマー形成阻害物質の作用機構とマウスにおける生体内代謝2023

    • Author(s)
      村上一馬、谷輪厚太、坂口嘉紀、泉尾直孝、花木瑞穂,川瀬泰司、廣瀬賢治、清水孝彦、入江一浩
    • Organizer
      第65回天然有機化合物討論会
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] Influence of amyloid β deposition around the pial artery on cerebral artery response during transient ischemia in Alzheimer’s disease model mice2023

    • Author(s)
      Nobuhiro Watanabe, Yoshihiro Noda, Taeko Nemoto, Kaori Iimura, Takahiko Shimizu, Harumi Hotta
    • Organizer
      Neurovascular Unit Conference 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] 老化モデルマウスにおいて加齢に伴い骨髄由来免疫抑制細胞が増加する2023

    • Author(s)
      徳本裕乃、畠山瑞生、前田真奈、上園帆風、森永真衣、嶋本顕、清水 孝彦、川上広宣、篠原久明、堀江一郎
    • Organizer
      第40回日本薬学会九州山口支部大会
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] 早老症の分子基盤から考えるエイジングリサーチ2022

    • Author(s)
      澁谷修一、清水孝彦
    • Organizer
      第95回日本生化学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] 個体老化と細胞老化の基礎研究2022

    • Author(s)
      清水孝彦
    • Organizer
      第12回運動器抗加齢医学研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] 個体老化と細胞老化の基礎研究2022

    • Author(s)
      清水孝彦
    • Organizer
      第12回運動器抗加齢医学研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] Mitochondrial ROS in fast muscle reversibly regulates glycogen metabolism and physical activity in mice2022

    • Author(s)
      Shuichi Shibuya, Ikko Sakamoto, Kenji Watanabe, Hidetoshi Nojiri, Takahiko Shimizu
    • Organizer
      第45回(2022年)日本基礎老化学会大会
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] Syringaresinol はFoxO3aを介しては皮膚萎縮や色素沈着を緩和する2022

    • Author(s)
      清水孝彦、金 周元
    • Organizer
      第45回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] アサイー果実による造血因子エリスロポエチン誘導作用2022

    • Author(s)
      澁谷修一、清水孝彦
    • Organizer
      第7回(2022年)NCGGサマーセミナー
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] SODsが制御する酸化ストレスと臓器老化2022

    • Author(s)
      清水孝彦
    • Organizer
      日本組織培養学会第94回大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] 速筋ミトコンドリアROSはグリコーゲン代謝および運動機能を可逆的に調節する2022

    • Author(s)
      澁谷修一、坂本一晃、渡辺憲史、野尻英俊、清水孝彦
    • Organizer
      第45回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] 個体老化と細胞老化の基礎研究2022

    • Author(s)
      清水孝彦
    • Organizer
      第64回日本老年医学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] 早老症サルコペニアの発症機構解明2022

    • Author(s)
      澁谷修一、清水孝彦
    • Organizer
      第9回骨格筋生物学研究会
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] アサイー果実による造血因子エリスロポエチン誘導作用2022

    • Author(s)
      澁谷修一、清水孝彦
    • Organizer
      第7回(2022年)NCGGサマーセミナー
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] マトリックスプロテアーゼと組織老化2022

    • Author(s)
      清水孝彦
    • Organizer
      第9回骨格筋生物学研究会
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] アサイー果実は腎蔵の低酸素化を介して造血ホルモンを増加する2022

    • Author(s)
      澁谷修一、渡辺憲史、Mario Jose Villegas Yata、清水孝彦
    • Organizer
      第22回日本抗加齢医学会総会
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] SODsが制御する酸化ストレスと臓器老化2022

    • Author(s)
      清水孝彦
    • Organizer
      日本組織培養学会第94回大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] Mitochondrial dysfunction in osteocytes caused age-related bone loss due to the nuclear lamina abnormalities2022

    • Author(s)
      Kenji Watanabe, Shuichi Shibuya, Keiji Kobayashi, Hidetoshi Nojiri, Takahiko Shimizu
    • Organizer
      第45回(2022年)日本基礎老化学会大会
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] SOD/カタラーゼ模倣薬は接触皮膚炎を緩和する2022

    • Author(s)
      岩田拓磨、澁谷修一、渡辺憲史、清水孝彦
    • Organizer
      日本農芸化学会2022年度大会
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] Syringaresinol はFoxO3aを介しては皮膚萎縮や色素沈着を緩和する2022

    • Author(s)
      清水孝彦、金 周元
    • Organizer
      第45回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] 臓器老化モデルマウスを用いた機能性食品評価2022

    • Author(s)
      清水孝彦
    • Organizer
      アンチエイジング・機能性食品開発のための動物モデルセミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] アサイー果実は腎蔵の低酸素化を介して造血ホルモンを増加する2022

    • Author(s)
      澁谷修一、渡辺憲史、Mario Jose Villegas Yata、清水孝彦
    • Organizer
      第22回日本抗加齢医学会総会
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] Mitochondrial ROS in fast muscle reversibly regulates glycogen metabolism and physical activity in mice2022

    • Author(s)
      Shuichi Shibuya, Ikko Sakamoto, Kenji Watanabe, Hidetoshi Nojiri, Takahiko Shimizu
    • Organizer
      第45回(2022年)日本基礎老化学会大会
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] 臓器老化モデルマウスを用いた機能性食品評価2022

    • Author(s)
      清水孝彦
    • Organizer
      アンチエイジング・機能性食品開発のための動物モデルセミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] Mitochondrial dysfunction in osteocytes caused age-related bone loss due to the nuclear lamina abnormalities2022

    • Author(s)
      Kenji Watanabe, Shuichi Shibuya, Keiji Kobayashi, Hidetoshi Nojiri, Takahiko Shimizu
    • Organizer
      第45回(2022年)日本基礎老化学会大会
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] ミトコンドリア機能不全を起因とする核ラミナ構造破綻が骨量減少の原因となる2022

    • Author(s)
      渡辺憲史、澁谷修一、清水孝彦
    • Organizer
      第45回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] 速筋ミトコンドリアROSはグリコーゲン代謝および運動機能を可逆的に調節する2022

    • Author(s)
      澁谷修一、坂本一晃、渡辺憲史、野尻英俊、清水孝彦
    • Organizer
      第45回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] 早老症の分子基盤から考えるエイジングリサーチ2022

    • Author(s)
      澁谷修一、清水孝彦
    • Organizer
      第95回日本生化学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] アサイー果実パルプ水溶液は腎低酸素誘導を介して造血因子erythropoietinを増加する2022

    • Author(s)
      澁谷修一、戸田年彦、渡辺憲史、Mario Jose Villegas Yata、清水孝彦
    • Organizer
      第18回ファンクショナルフード学会学術集会
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] 個体老化と細胞老化の基礎研究2022

    • Author(s)
      清水孝彦
    • Organizer
      第64回日本老年医学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K19607
  • [Presentation] ミトコンドリア機能不全を起因とする核ラミナ構造破綻が骨量減少の原因となる2022

    • Author(s)
      渡辺憲史、澁谷修一、清水孝彦
    • Organizer
      第45回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] SODによる抗酸化防御と臓器老化2021

    • Author(s)
      清水孝彦
    • Organizer
      第94回日本生化学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] Pathological cross-talk between intracellular superoxide metabolism and p53 signaling in murine models2021

    • Author(s)
      Kenji Watanabe, Shuichi Shibuya, Takahiko Shimizu
    • Organizer
      第44回(2021年)日本基礎老化学会大会
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] Wrn and Recql5 deletions promote adipose senescence and dyslipidemia2021

    • Author(s)
      Shuichi Shibuya, Yusuke Ozawa, Kotarou Yokote, Takahiko Shimizu
    • Organizer
      第44回(2021年)日本基礎老化学会大会
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] Influence of amyloid β deposition around the cerebral artery on cerebrovascular response during transient ischemia2021

    • Author(s)
      Nobuhiro Watanabe, Yoshihiro Noda, Taeko Nemoto, Kaori Iimura, Takahiko Shimizu, Harumi Hotta
    • Organizer
      第44回(2021年)日本基礎老化学会大会
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] ミトコンドリア局在型SODによる骨格筋グリコーゲン代謝制御2021

    • Author(s)
      清水孝彦
    • Organizer
      第8回骨格筋生物学研究会
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] Superoxide dismutase 2 is involved in the senescence of dentin-pulp complex.2021

    • Author(s)
      Tomohiro Itoyama, Kenji Watanabe, Masataka Kadowaki, Hiroshi Kaneko, Shinichiro Yoshida, Takahiko Shimizu, Hidefumi Maeda
    • Organizer
      The 19th Joint Scientific Meeting between Japan Endodontic Association and Korean Association of Endodontic 2021 (JEA-KAE 2021)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] 新規早老症モデルマウスの骨格筋病態機能2021

    • Author(s)
      澁谷修一、清水孝彦
    • Organizer
      第8回骨格筋生物学研究会
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] SODによる骨格筋恒常性維持機構2021

    • Author(s)
      清水孝彦
    • Organizer
      第76回日本体力医学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] Empagliflozin Improves Prognosis and Energy Properties in Failing Murine Heart2021

    • Author(s)
      Aya Shiraki, Jun-ichi Oyama, Takahiko Shimizu, Takayuki Nakashima, Takashi Yokota, Koichi Node
    • Organizer
      European Society of Cardiology Congress 2021 (ESC 2021)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] 酸化ストレスを起因とした加齢性組織変化とp53シグナルの関連性2021

    • Author(s)
      渡辺憲史、澁谷修一、清水孝彦
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] アサイー果実抽出物は腎低酸素化を介して造血因子erythropoietinを増加する2021

    • Author(s)
      澁谷修一、戸田年彦、渡辺憲史、Mario Jose Villegas Yata、清水孝彦
    • Organizer
      日本農芸化学会2021年度大会
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] 新規ウェルナー早老症モデルマウスは脂肪細胞老化および脂質代謝異常を呈する2021

    • Author(s)
      澁谷修一、小澤裕介、横手幸太郎、清水孝彦
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] Mitochondrial ROS in muscle regulates motor function via glycogen metabolism in mice2020

    • Author(s)
      Takahiko Shimizu
    • Organizer
      The 6th NCGG-ICAH
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] アミロイドβ42の毒性オリゴマーを認識するRNAアプタマーの開発2020

    • Author(s)
      村上一馬、小畑弥生、関川あさ、上田遥、川瀬泰司、広瀬賢治、泉尾直孝、清水孝彦、入江一浩
    • Organizer
      第62回天然有機化合物討論会
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] ADモデルマウスにおける大脳皮質動脈周囲のアミロイドβ蓄積が一過性虚血中の動脈径変化に対する影響2020

    • Author(s)
      渡辺信博、野田義博、根本妙子、飯村佳織、清水孝彦、堀田晴美
    • Organizer
      第43回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] 一過性脳虚血時の軟膜動脈拡張反応に対する血管周囲のアミロイドβ蓄積の影響2020

    • Author(s)
      渡辺信博、野田義博、根本妙子、飯村佳織、清水孝彦、堀田晴美
    • Organizer
      第73回日本自律神経学会総会
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] 体性感覚刺激による脳血流増加反応に対するアミロイドβの影響2020

    • Author(s)
      渡辺信博、野田義博、飯村佳織、清水孝彦、堀田晴美
    • Organizer
      第43回(2020年)日本基礎老化学会大会
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] RNA aptamers that recognize amyloid β oligomers in AppNL-G-F/NL-G-F mice as a model of Arctic Alzheimer disease2020

    • Author(s)
      Kazuma Murakami, Yayoi Obata, Tajii Kawase, Keiji Hirose, Naotaka Izuo, Takahiko Shimizu, Kazuhiro Irie.
    • Organizer
      Alzheimer's Association International Conference 2020 (AAIC 2020)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] 老化制御研究におけるファンクショナルフードの役割2020

    • Author(s)
      清水孝彦
    • Organizer
      第15回ファンクショナルフード学会研修会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] 白金/パラジウム黒色溶液はSOD/カタラーゼ活性を持つナノ医療素材である2020

    • Author(s)
      澁谷修一、渡辺憲史、清水孝彦
    • Organizer
      第43回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] Wrn and Recql5 deletions accerelate adipose senescence and dyslipidemia2020

    • Author(s)
      澁谷修一、小澤裕介、横手幸太郎、清水孝彦
    • Organizer
      第43回(2020年)日本基礎老化学会大会
    • Data Source
      KAKENHI-PROJECT-20H03583
  • [Presentation] アミロイドβ42の毒性オリゴマーに対する核酸アプタマーの開発研究と脳組織染色への応用2019

    • Author(s)
      村上一馬、小畑弥生、関川あさ、上田 遥、泉尾直孝、粟野達也、高部圭司、清水孝彦、入江一浩
    • Organizer
      2019年度日本農芸化学会大会(東京農大、東京)優秀発表
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] RNA aptamers targeting the toxic oligomers of Aβ42 and their application to immunohistochemistry2018

    • Author(s)
      Murakami Kazuma、Obata Yayoi、Sekikawa Asa、Ueda Haruka、Izuo Naotaka、Awano Tatsuya、Takabe Keiji、Shimizu Takahiko、Irie Kazuhiro
    • Organizer
      The 45th International Symposium on Nucleic Acids Chemistry (Kyoto University Clock Tower Centennial Hall, Kyoto, Japan)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] 青ジソに含まれるアミロイドβ42の凝集阻害物質の作用機構とマウスにおける生体内代謝2018

    • Author(s)
      坂口嘉紀、村上一馬、花木瑞穂、泉尾直孝、小澤祐介、粟野達也、高部圭司、川瀬泰司、廣瀬賢治、三羽伸明、久米利明、清水孝彦、入江一浩
    • Organizer
      2018年度日本農芸化学会大会(大会トピックス賞)(名城大学、名古屋市)
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] アミロイドβ「毒性コンホマー」を標的にしたアルツハイマー病の治療・診断法の開発2017

    • Author(s)
      泉尾直孝、久米利明、村上一馬、徳田隆彦、前田雅弘、入江一浩、清水孝彦
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-25
    • Invited
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] Mitochondrial SOD in osteocytes plays a pivotal role in maintaining bone metabolism in mice.2017

    • Author(s)
      Takahiko Shimizu, Keiji Kobayashi, Hidetoshi Nojiri.
    • Organizer
      Asian Society of Aging Research Symposium 2017
    • Place of Presentation
      札幌グランドホテル(北海道札幌市)
    • Year and Date
      2017-03-02
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462283
  • [Presentation] Aβ42の22-23位におけるターン構造はAβ42誘発神経毒性を調節する2016

    • Author(s)
      泉尾直孝、久米利明、村上一馬、前田雅弘、入江一浩、清水孝彦
    • Organizer
      日本基礎老化学会大会
    • Place of Presentation
      伊勢原市民文化会館(神奈川県伊勢原市)
    • Year and Date
      2016-05-27
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] Identification of the “toxic conformer” of amyloid β and its pathogenic contribution of Alzheimer's disease2016

    • Author(s)
      Naotaka Izuo, Kazuma Murakami, Toshiaki Kume, Masahiro Maeda, Kazuhiro Irie, Takahiko Shimizu
    • Organizer
      2016 Spring International Conference of the Korean Society for Gerontology
    • Place of Presentation
      Convention Hall (Daegu, Korea)
    • Year and Date
      2016-06-16
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] Pathological significance of telomere in a model mouse for Werner syndrome.2016

    • Author(s)
      Shuichi Shibuya, Koutaro Yokote, Takahiko Shimizu.
    • Organizer
      RecQ helicase symposium 2016
    • Place of Presentation
      Seattle(米国)
    • Year and Date
      2016-05-28
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462283
  • [Presentation] アミロイドβのラジカル化:アルツハイマー病態におけるSOD1の役割2016

    • Author(s)
      村上一馬、清水孝彦、入江一浩
    • Organizer
      第11回レドックス・ライフイノベーションシンポジウム
    • Place of Presentation
      お茶の水女子大学(東京都文京区)
    • Year and Date
      2016-03-17
    • Invited
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] Passive immunization with the toxic conformer of Aβ ameliorated behavioral abnormalities in Alzheimer’s-like model without affecting senile plaque deposition2016

    • Author(s)
      泉尾直孝、村上一馬、久米利明、入江一浩、横手幸太郎、清水孝彦
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-03-10
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration.2016

    • Author(s)
      Takahiko Shimizu, Masato Koike, Hidetoshi Nojiri.
    • Organizer
      Cell symposia Aging & Metabolism
    • Place of Presentation
      Melia Stiges(スペイン)
    • Year and Date
      2016-07-10
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462283
  • [Presentation] Apple polyphenols protect cartilage degeneration through modulating mitochondrial function in mice.2016

    • Author(s)
      Isao Masuda, Masato Koike, Yusuke Ozawa, Kenji Watanabe, Shohei Nakashima, Hiroshi Sugiyama, Tomomasa Kanda Hidetoshi Nojiri, Takahiko Shimizu.
    • Organizer
      2016 World Congress of Osteoarthritis Research Society International
    • Place of Presentation
      Amsterdam(オランダ)
    • Year and Date
      2016-04-01
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462283
  • [Presentation] アミロイドβの毒性コンホマーにきわめて特異的な抗体の開発とアルツハイマー病診断への応用2016

    • Author(s)
      村上一馬、徳田真樹、鈴木天志、入江由美、花木瑞穂、柳田亮、物部容子、赤木謙一、石井亮太郎、建部陽嗣、徳田隆彦、前田雅弘、久米利明、泉尾直孝、清水孝彦、入江一浩
    • Organizer
      2016年度日本農芸化学会大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-28
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] Mitochondrial superoxide regulation in chondrocytes suppresses mechanical overloading-induced cartilage degeneration.2016

    • Author(s)
      Masato Koike, Hidetoshi Nojiri, Haruka Kaneko, Daichi Morikawa, Keiji Kobayashi, Yoshitomo Saita, Kazuo Kaneko, Takahiko Shimizu.
    • Organizer
      Orthopaedic Research Society (ORS) Annual Meeting 2016
    • Place of Presentation
      Orlando (USA)
    • Year and Date
      2016-03-05
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462283
  • [Presentation] Characterization of the monoclonal antibody (24B3) highly recognizing the toxic turn of amyloid β42 and its application to diagnosis for Alzheimer’s disease2016

    • Author(s)
      Kazuma Murakami, Mizuho Hanaki, Maki Tokuda, Ken-ichi kagi, Ryotaro Ishii, Harutsugu Tatebe, Takahiko Tokuda, Masahiro Maeda, Naotaka Izuo, Takahiko Shimizu, Kazuhiro Irie
    • Organizer
      The 8th Takeda Science Foundation Symposium on PharmaSciences “Biomolecule-based Medicinal Science: Featuring Mid-Size Drugs”
    • Place of Presentation
      Takeda Pharmaceutical Company, Ltd. (Suita, Japan)
    • Year and Date
      2016-01-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] Identification of the “Toxic Conformer” of Amyloid β and its Pathogenic Contribution of Alzheimer’s Disease.2016

    • Author(s)
      Naotaka Izuo, Kazuma Murakami, Toshiaki Kume, Masahiro Maeda, Kazuhiro Irie, Takahiko Shimizu
    • Organizer
      The Japan-Korea Joint Aging Symposium
    • Place of Presentation
      Daegu(韓国)
    • Year and Date
      2016-06-15
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462283
  • [Presentation] Aβ 毒性コンホマーの選択的除去は老人斑に影響せずアルツハイマー病症状を改善する2015

    • Author(s)
      泉尾直孝、村上一馬、前田雅弘、久米利明、横手幸太郎、入江一浩、清水孝彦
    • Organizer
      第34回日本認知症学会学術集会
    • Place of Presentation
      リンクステーションホール青森(青森県青森市)
    • Year and Date
      2015-10-02
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] アミロイドβの「毒性コンホマー」を標的とした受動免疫療法はアルツハイマー病モデルの神経症状を改善する2015

    • Author(s)
      泉尾直孝、村上一馬、徳田隆彦、久米利明、赤池昭紀、白澤卓二、横手幸太郎、入江一浩、清水孝彦
    • Organizer
      日本基礎老化学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-06-13
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] Pathophysiological activities of the “toxic conformer” and the “non-toxic conformer” of amyloid β-induced neurotoxicity2015

    • Author(s)
      泉尾直孝、久米利明、村上一馬、入江一浩、泉 安彦、赤池昭紀、横手幸太郎、清水孝彦
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2015-03-19
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] Aβ毒性コンホマーの選択的除去は老人班蓄積を阻害せずにアルツハイマー病モデルマウスの行動異常を改善する2015

    • Author(s)
      泉尾直孝、村上一馬、前田雅弘、久米利明、横手幸太郎、入江一浩、清水孝彦
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-04
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] Mn-SOD loss in osteocytes causes age-related bone loss associated with impairment of bone remodeling.2015

    • Author(s)
      Takahiko Shimizu, Keiji Kobayashi, Hidetoshi Nojiri
    • Organizer
      The 10th IAGG (International Association of Gerontology and Geriatrics) Asia/Oceania 2015 Congress
    • Place of Presentation
      Chiang Mai (Thailand)
    • Year and Date
      2015-10-19
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462283
  • [Presentation] Characterization of monoclonal antibodies against the toxic turn of amyloid β42 and their application to diagnosis for Alzheimer’s disease2015

    • Author(s)
      Kazuma Murakami, Mizuho Sato-Hanaki, L. M. Moro, G. Giaccone, F. Tagliavini, Ken-ichi Akagi, Ryotaro Ishii, Takahiko Tokuda, Masahiko Maeda, Naotaka Izuo, Takahiko Shimzu, Kazuhiro Irie
    • Organizer
      2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015)
    • Place of Presentation
      Hilton Hawaiian Villege (Honolulu, USA)
    • Year and Date
      2015-12-15
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] SOD2 loss in osteocytes perturbs canalicular networks associated with impairment of bone remodeling in age-related osteoporosis.2015

    • Author(s)
      Takahiko Shimizu, Keiji Kobayashi, Hidetoshi Nojiri, Koutaro Yokote
    • Organizer
      Biology of Ageing Conference
    • Place of Presentation
      Singapore
    • Year and Date
      2015-10-22
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462283
  • [Presentation] アミロイドβの毒性コンホマーを極めて特異的に認識する抗体の開発とAD診断への応用2015

    • Author(s)
      村上一馬、花木瑞穂、赤木謙一、石井亮太郎、徳田隆彦、前田雅弘、泉尾直孝、清水孝彦、入江一浩
    • Organizer
      第34回日本認知症学会学術集会
    • Place of Presentation
      リンクステーションホール青森(青森県青森市)
    • Year and Date
      2015-10-02
    • Data Source
      KAKENHI-PROJECT-26221202
  • [Presentation] Contribution of mitochondrial superoxide and SOD2 imbalance to the locomotive syndrome.2015

    • Author(s)
      Hidetoshi Nojiri, Daichi Morikawa, Keiji Kobayashi, Masato Koike, Yoshitomo Saita, Kazuo Kaneko, Takahiko Shimizu
    • Organizer
      The 2nd International Academy of Sportology
    • Place of Presentation
      順天堂大学(東京都文京区)
    • Year and Date
      2015-09-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462283
  • [Presentation] Oxidative stress, aging and progeric syndrome. Recent progress in basic and clinical research on progeroid syndrome2013

    • Author(s)
      Shimizu, T., Koyama, H., Shibuya, S., Shimamoto, A., Takemoto, M., Yokote, K.
    • Organizer
      The 20^<th> IAGG World Congress of Gerontology and Geriatrics (IAGG 2013)
    • Place of Presentation
      Seoul Korea
    • Data Source
      KAKENHI-PROJECT-24659346
  • [Presentation] Osteocyte Specific Deletion of Superoxide Dismutase2 Induces Osteocyte Loss Resulting in Bone Loss Associated with Impairment of Bone Remodeling2013

    • Author(s)
      Keiji Kobayashi, Hidetoshi Nojiri, Yoshitomo Saita, Daichi Morikawa, Masato Koike, Yusuke Ozawa, Yoshinori Asou, Kazuo Kaneko, Takahiko Shimizu,
    • Organizer
      2013 ASBMR Annual Meeting Abstracts
    • Place of Presentation
      Baltimore, USA
    • Data Source
      KAKENHI-PROJECT-24791568
  • [Presentation] Vitamin C and silymarin restores Aβ oligomerization and behavioral abnormality in Alzheimer's pathology2013

    • Author(s)
      Murakami, K., Murata, N., Ozawa, Y., Irie, K., Shirasawa, T., Shimizu, T
    • Organizer
      Alzheimer's Association International Conference (AAIC) 2013
    • Place of Presentation
      Boston, USA
    • Year and Date
      2013-07-15
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Presentation] 細胞質活性酸素とSOD1は機械的刺激応答に伴う骨量変化を制御する2013

    • Author(s)
      清水 孝彦, 森川 大智, 野尻 英俊, 斎田 良知, 渡辺 憲史, 麻生 義則, 金子 和夫
    • Organizer
      日本基礎老化学会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-24791568
  • [Presentation] 骨細胞特異的Sod2欠損マウスにおける骨リモデリング制御機構の解析2013

    • Author(s)
      小林 慶司, 野尻 英俊, 齋田 良知, 森川 大智, 小池 正人, 麻生 義則, 金子 和夫, 清水 孝彦
    • Organizer
      日本骨代謝学会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-24791568
  • [Presentation] 骨細胞における抗酸化酵素Sod2の骨リモデリング制御機構2013

    • Author(s)
      小林 慶司, 野尻 英俊, 齋田 良知, 森川 大智, 小池 正人, 麻生 義則, 金子 和夫, 清水 孝彦
    • Organizer
      日本整形外科学会基礎学術集会
    • Place of Presentation
      幕張メッセ
    • Data Source
      KAKENHI-PROJECT-24791568
  • [Presentation] Mn-SOD欠損細胞及びマウスに対するMnポルフィリンダイマー含有リポソームの抗酸化活性評価2012

    • Author(s)
      米田祥浩, 山口翔平,清水孝彦, 朝山章一郎, 川上浩良
    • Organizer
      第61回高分子学会年次大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2012-05-31
    • Data Source
      KAKENHI-PROJECT-22300166
  • [Presentation] インスリン抵抗性による高インスリン血症はアルツハイマー病様症状を増悪しない2012

    • Author(s)
      清水孝彦
    • Organizer
      2012年度日本農芸化学会大会
    • Place of Presentation
      京都女子大学(京都市)
    • Year and Date
      2012-03-24
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Presentation] スーパーオキサイドディスムターゼ1(SOD1)欠損は低代謝回転型骨量減少と加齢性コラーゲン架橋変化を引き起こし骨脆弱化する2012

    • Author(s)
      野尻 英俊, 斎田 良知, 森川 大智, 小林 慶司, 宮崎 剛, 斎藤 充, 丸毛 啓史, 金子 和夫, 清水 孝彦
    • Organizer
      第30回日本骨代謝学会学術集会
    • Place of Presentation
      新宿
    • Data Source
      KAKENHI-PROJECT-24791568
  • [Presentation] 細胞質酸化ストレスは低代謝型骨量減少を引き起こす2012

    • Author(s)
      森川 大智, 野尻 英俊, 斎田 良知, 津田 千鶴, 斎藤 充, 宮崎 剛, 金子 和夫, 清水 孝彦
    • Organizer
      日本生化学会大会・日本分子生物学会年会合同大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-24791568
  • [Presentation] コエンザイムQ10はclk-1変異線虫の寿命延長と行動リズム遅延及びclk-1欠損マウスの生体リズム遅延を完全レスキューする.2012

    • Author(s)
      1. 高橋真由美、小河原緑、清水孝彦、白澤卓二.
    • Organizer
      第35回日本基礎老化学会大会
    • Place of Presentation
      東邦大学
    • Data Source
      KAKENHI-PROJECT-23617042
  • [Presentation] インスリン抵抗性による高インスリン血症はアルツハイマー病様症状を増悪しない2012

    • Author(s)
      清水孝彦
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都女子大学
    • Year and Date
      2012-03-24
    • Data Source
      KAKENHI-PROJECT-22603006
  • [Presentation] Monoclonal antibody against a toxic conformer of Aβ42 with a turn at E22-D232012

    • Author(s)
      Irie, K., Murakami, K., Horikoshi-Sakuraba, Y., Kinoshikta, N., Shirasawa, T., Shimizu, T., Tokuda, T
    • Organizer
      Alzheimer's Association International Conference (AAIC) 2012
    • Place of Presentation
      Vancouver, British Columbia, Canada
    • Year and Date
      2012-07-15
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Presentation] メカニカルストレス応答における酸化ストレスと抗酸化酵素の解析2012

    • Author(s)
      森川 大智, 野尻 英俊, 齋田 良知, 小林 慶司, 渡辺 憲史, 麻生 義則, 金子 和夫, 清水 孝彦
    • Organizer
      第30回日本骨代謝学会学術集会
    • Place of Presentation
      新宿
    • Data Source
      KAKENHI-PROJECT-24791568
  • [Presentation] コエンザイムQの新たな機能:生体リズムと寿命の調節.2012

    • Author(s)
      2. 高橋真由美、小河原緑、清水孝彦、白澤卓二.
    • Organizer
      第35回日本分子生物学会大会
    • Place of Presentation
      福岡国際会議場
    • Data Source
      KAKENHI-PROJECT-23617042
  • [Presentation] Silymarin attenuated the amyloid βdeposition and behavioral abnormalities in a mouse model of Alzheimer's disease2011

    • Author(s)
      Takahiko Shimizu
    • Organizer
      41st Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Convention Center (Washington, USA)
    • Year and Date
      2011-11-16
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Presentation] Mnポルフィリンダイマーを用いたSOD欠損細胞に対する抗酸化評価2011

    • Author(s)
      窪田陸,田端久志, 清水孝彦(都健康長寿医療センター研),朝山章一郎,川上浩良
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡県立大学・静岡県コンベンションアーツセンター・ツインメッセ静岡
    • Data Source
      KAKENHI-PROJECT-22300166
  • [Presentation] Antioxidant, EUK-8, prevents murine dilated cardiomyopathy.2010

    • Author(s)
      Shirasawa, T., Kawakami, S., Shimizu, T.
    • Organizer
      Gordon Research Conferences
    • Place of Presentation
      Les Diablerets, Switzerland
    • Data Source
      KAKENHI-PROJECT-20500641
  • [Presentation] 筋細胞におけるミトコンドリア内酸化ストレスは呼吸鎖を障害し著しい運動能力の低下をきたす2010

    • Author(s)
      野尻英俊、桑原宏朋、森川大智、斎田良知、金子和夫、清水孝彦
    • Organizer
      第25回日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-20500641
  • [Presentation] Antioxidant, EUK-8, prevents murine dilated cardiomyopathy.2010

    • Author(s)
      Shirasawa T., Kawakami S., Shimizu T.
    • Organizer
      Gordon Research Conferences
    • Place of Presentation
      Les Diablerets, Switzerland
    • Data Source
      KAKENHI-PROJECT-20390085
  • [Presentation] アミロイドβ の毒性コンホマーを標的とした立体構造特異的抗体2010

    • Author(s)
      村上一馬, 堀越(櫻庭)優子, 村田 央, 野田義博, 増田裕一, 木下憲明, 初田裕幸, 村山繁雄, 白澤卓二, 清水孝彦, 入江一浩
    • Organizer
      2010年度日本農芸化学会大会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-29
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Presentation] 細胞質酸化ストレスは低代謝型骨減少症を引き起こす2010

    • Author(s)
      森川大智、野尻英俊、斎田良知、津田千鶴、斎藤充、宮崎剛、金子和夫、清水孝彦
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-20500641
  • [Presentation] アミロイドβ (Aβ42) の毒性コンホマー特異的抗体の作製2010

    • Author(s)
      村上一馬, 堀越(櫻庭)優子, 村田 央, 野田義博, 増田裕一, 木下憲明, 初田裕幸, 村山繁雄, 白澤卓二, 清水孝彦, 入江一浩
    • Organizer
      第52回天然有機化合物討論会
    • Place of Presentation
      静岡
    • Year and Date
      2010-09-30
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Presentation] Meet the Expert 1講演名:酸化ストレスと骨代謝-SOD欠損マウスを用いた解析-2010

    • Author(s)
      清水孝彦
    • Organizer
      第28回日本骨代謝学会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-21
    • Data Source
      KAKENHI-PROJECT-21791416
  • [Presentation] Intracellular superoxide dismutase deficiency decreased bone mass in vivo by impairment of cell viability and redox balance in osteoblasts.2010

    • Author(s)
      Saita, Y.Nojiri, H.Tsuda, C.Miyazaki, T.Morikawa, D., Kaneko, K.Shimizu, T.
    • Organizer
      The 32th Annual Meeting, The American Society for Bone and Mineral Research (ASBMR), Tronto
    • Place of Presentation
      Canada
    • Data Source
      KAKENHI-PROJECT-20500641
  • [Presentation] 細胞内SOD欠損による運動器障害の解析2010

    • Author(s)
      清水孝彦、白澤卓二
    • Organizer
      第33回日本分子生物学会年会・第83 回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-20500641
  • [Presentation] 臓器特異的にMn-SODをノックアウトしたマウス・心筋組織のミトコンドリアの形態2009

    • Author(s)
      立花利公、野尻英俊、清水孝彦、岡部正隆、白澤卓二
    • Organizer
      日本顕微鏡学会第65回学術講演会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-20500641
  • [Presentation] Copper/zinc superoxide dismutase deficiency causes low turnover osteopenia via osteoblastic dysfunction.2009

    • Author(s)
      Nojiri, H.Saita, Y.Tsuda, C.Morikawa, D., Kurosawa, H.Shimizu, T.
    • Organizer
      The 31th Annual Meeting, The American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      Denver, Colorado
    • Data Source
      KAKENHI-PROJECT-20500641
  • [Presentation] Oxidative stress in skeletal muscle causes severe disturbance of exercise activity without muscle atrophy.2009

    • Author(s)
      Shimizu, T.Horie, T.Kuwahara, H.Ishikawa, S.Tsuda, C.Kaneko, T.Tahara, S.Nojiri, N.Shirasawa, T.
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-20500641
  • [Presentation] Mn-SOD コンディショナルノックアウトマウスを用いた抗老化研究2009

    • Author(s)
      清水孝彦、白澤卓二
    • Organizer
      第123回日本薬学会年会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-20500641
  • [Presentation] ミ活性酸素と臓器老化-SOD欠損マウスを用いた解析-2009

    • Author(s)
      清水孝彦、白澤卓二
    • Organizer
      第9回日本抗加齢医学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-20500641
  • [Presentation] Copper/zinc superoxide dismutase deficiency causes low turnover osteopenia.2009

    • Author(s)
      Tsuda, C.Nojiri, H.Saita, Y.Miyazaki, T.Ozawa, Y.Morikawa, D.Shimizu, T.
    • Organizer
      第32回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-20500641
  • [Presentation] 骨格筋特異的Mn-SOD欠損マウスの酸化ストレスによる運動能不全の解析2009

    • Author(s)
      堀江哲郎、津田千鶴、石川慎、野田義博、桑原宏朋、川上哲、小澤裕介、白澤卓二、清水孝彦
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-20500641
  • [Presentation] 抗酸化剤投与によるMn-SOD欠損に起因する拡張型心筋症の予防と治療2008

    • Author(s)
      川上哲、松田瑛奈、金子孝夫、田原正一、砂川忠広、白澤卓二、清水孝彦
    • Organizer
      日本基礎老化学会第31回大会
    • Place of Presentation
      松本
    • Data Source
      KAKENHI-PROJECT-20500641
  • [Presentation] 骨格筋の運動機能におけるMn-SODの役割2008

    • Author(s)
      清水孝彦、堀江哲郎、桑原宏朋、津田千鶴、石川慎、野田義博、川上哲、白澤卓二
    • Organizer
      日本基礎老化学会第31回大会
    • Place of Presentation
      松本
    • Data Source
      KAKENHI-PROJECT-20500641
  • [Presentation] CuZn-SOD欠損マウスは加齢性皮膚炎を発症する2008

    • Author(s)
      稲垣潤、池田泰隆、川上哲、白澤卓二、清水孝彦
    • Organizer
      第8回日本抗加齢医学会総会
    • Data Source
      KAKENHI-PROJECT-20500641
  • [Presentation] 抗酸化剤投与によるmitochondrial cardiomyopathyの予防と治療2008

    • Author(s)
      川上哲、松田瑛奈、金子孝夫、田原正一、白澤卓二、清水孝彦
    • Organizer
      第8回日本抗加齢医学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-20500641
  • [Presentation] ミトコンドリアフリーラジカルと臓器障害2008

    • Author(s)
      清水孝彦、白澤卓二
    • Organizer
      第8回日本抗加齢医学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-20500641
  • [Presentation] 骨格筋特異的Mn-SOD欠損マウスを用いた筋機能と活性酸素過剰解析2008

    • Author(s)
      堀江哲郎、津田千鶴、石川慎、野田義博、桑原宏朋、川上哲、小澤裕介、吉田朋恵、白澤卓二、清水孝彦
    • Organizer
      第8回日本抗加齢医学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-20500641
  • [Presentation] Analysis of heart/muscle-specific Mn-SOD-deficient mice.The Japan-Korea Joint Seminar : Toward the Establishment of Asian Aging Research and Education Center2008

    • Author(s)
      Shimizu, T.
    • Organizer
      Nagasaki
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-20500641
  • [Presentation] アミロイドβペプチドのターン構造形成とアスパラギン酸残基修飾2007

    • Author(s)
      清水 孝彦
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-11
    • Data Source
      KAKENHI-PROJECT-18208011
  • [Presentation] SOD2 deficiency in chondrocytes accelerates age-related osteoarthritis in mice

    • Author(s)
      M. Koike, H. Nojiri, Y. Ozawa, K. Watanabe, I. Masuda, Y. Muramatsu, H. Kaneko, D. Morikawa, K. Kobayashi, Y. Saita, T. Sasho, T. Shirasawa, K. Yokote, K. Kaneko, T. Shimizu
    • Organizer
      Osteoarthritis and Cartilage 2014 World Congress
    • Place of Presentation
      Paris, France
    • Year and Date
      2014-04-24 – 2014-04-27
    • Data Source
      KAKENHI-PROJECT-24791568
  • [Presentation] Oxidative stress, aging and progeric syndrome. Recent progress in basic and clinical research on progeric syndrome.

    • Author(s)
      Takahiko Shimizu, Hirofumi Koyama, Shuichi Shibuya, Akira Shimamoto, Minoru Takemoto, Koutaro Yokote.
    • Organizer
      The 20th IAGG World Congress of Gerontology and Geriatrics
    • Place of Presentation
      COEX(韓国、ソウル)
    • Data Source
      KAKENHI-PROJECT-24659346
  • [Presentation] Mitochondrial superoxide in chondrocytes regulates age-related osteoarthritis.

    • Author(s)
      Takahiko Shimizu
    • Organizer
      The 4th International Symposium of Asian Association of Aging Research (AAAR) 2014
    • Place of Presentation
      Beijing (China)
    • Year and Date
      2014-11-07 – 2014-11-09
    • Invited
    • Data Source
      KAKENHI-PROJECT-26462283
  • [Presentation] Superoxide dismutase 2 deficiency in osteocytes causes age-related bone loss associated with impairment of bone remodeling.

    • Author(s)
      Takahiko Shimizu, Keiji Kobayashi, Hidetoshi Nojiri.
    • Organizer
      The Japan-Korea Joint Symposium 2014
    • Place of Presentation
      Jeju (Korea)
    • Year and Date
      2014-06-20 – 2014-06-21
    • Invited
    • Data Source
      KAKENHI-PROJECT-26462283
  • [Presentation] SOD1 insufficiency exacerbates Alzheimer’s-like phenotypes in mice

    • Author(s)
      Shimizu, T. et al.
    • Organizer
      The 20th IAGG World Congress of Gerontology and Geriatrics
    • Place of Presentation
      Coex (Seoul, Korea)
    • Data Source
      KAKENHI-PROJECT-21248015
  • [Presentation] SOD1の減少はアルツハイマー病様病態を早期に発症させる

    • Author(s)
      清水孝彦
    • Organizer
      第12回日本抗加齢医学会
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-22603006
  • [Presentation] 骨細胞における酸化ストレスは骨リモデリングバランスの破綻をもたらす

    • Author(s)
      小林 慶司, 野尻 英俊, 齋田 良知, 森川 大智, 小池 正人, 小澤 裕介, 麻生 義則, 金子 和夫, 清水 孝彦
    • Organizer
      日本整形外科学会
    • Place of Presentation
      神戸国際展示場
    • Year and Date
      2014-05-22 – 2014-05-25
    • Data Source
      KAKENHI-PROJECT-24791568
  • [Presentation] 早老症の病態と幹細胞

    • Author(s)
      横手幸太郎、清水孝彦、竹本稔
    • Organizer
      第13回日本抗加齢医学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-24659346
  • [Presentation] 細胞質局在型SODの減少はアミロイドβオリゴマー形成と記憶障害を促進する

    • Author(s)
      清水 孝彦
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Data Source
      KAKENHI-PROJECT-21248015
  • 1.  IRIE Kazuhiro (00168535)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 47 results
  • 2.  SHIRASAWA Takuji (80226323)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 3.  TAKEGOSHI Kiyonori (10206964)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 8 results
  • 4.  TOMITA Kengo (50317129)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 5.  MURAKAMI Kazuma (80571281)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 33 results
  • 6.  NOJIRI Hidetoshi (10317456)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 25 results
  • 7.  YOKOTE Koutaro (20312944)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 6 results
  • 8.  澁谷 修一 (70866342)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 57 results
  • 9.  SAITA Yoshitomo (00534885)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 11 results
  • 10.  TAKAHASHI Mayumi (50133632)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 11.  竹本 稔 (60447307)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  渡辺 憲史 (90866766)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 60 results
  • 13.  KAWAKAMI Hiroyoshi (10221897)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 14.  ASAYAMA Shoichiro (90315755)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 15.  USUI MICHIHIKO (10453630)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  YAMAGUCHI Hiroo (00701830)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  KIRA Jun-ichi (40183305)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  OGAWARA Midori (60100111)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  MORIIZUMI Eiko (20322711)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  久米 利明 (10303843)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 14 results
  • 21.  徳田 隆彦 (80242692)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 22.  喜田 昭子 (70273430)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  前澤 善朗 (80436443)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  ASOU Yoshinori
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 25.  DAISUKE Matsuzawa
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 26.  NAKAJIMA Madoka
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 27.  白沢 卓二
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 9 results
  • 28.  清水 直美
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  清水 栄司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 30.  平野 好幸
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  中里 道子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 32.  秋元 義弘
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 33.  菅野 秀宣
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 34.  新井 一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 35.  宮嶋 雅一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 36.  青木 茂樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 37.  川戸 佳
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 38.  藤本 千里
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 39.  歌 大介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 40.  白石 安永
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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