TANUMA Nobuhiro 田沼延公

Researcher Number	40333645
Other IDs
Affiliation (Current)	2025: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 部長
Affiliation (based on the past Project Information) *help	2022 – 2024: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 部長 2021: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 上席主任研究員 2011 – 2021: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 主任研究員 2014: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), その他部局等, 研究員 2013: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 主任研究員 … More 2012: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), その他部局等, 研究員 2012: 宮城県立がんセンター(研究所), がん薬物療法研究部, 主任研究員 2011: 宮城県立がんセンター(研究所), 薬物療法学部, 主任研究員 2010: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), 薬物療法学部, 研究員 2006 – 2010: Miyagi Cancer Center Research Institute, Division of Cancer Chemotherapy, Staff, 薬物療法学部, 研究員 2008 – 2009: 宮城県立がんセンター研究所, 薬物療法学部, 研究員 2006: 宮城県立がんセンター(研究所), 研究員 2001 – 2005: Hokkaido Univ. Inst. Genet. Med. Inst., 遺伝子病制御研究所, 助手 Less
Review Section/Research Field	Principal Investigator Medium-sized Section 50:Oncology and related fields / Tumor biology / Basic Section 50010:Tumor biology-related / Tumor biology and related fields / Tumor biology / Molecular biology / Functional biochemistry Except Principal Investigator Functional biochemistry / Digestive surgery / Basic Section 56040:Obstetrics and gynecology-related … More / Tumor therapeutics / Thoracic surgery / Functional biochemistry / Biological Sciences / Basic Section 56010:Neurosurgery-related / Tumor biology / Cerebral neurosurgery / Basic Section 55040:Respiratory surgery-related / Basic Section 53030:Respiratory medicine-related / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Neurosurgery / Clinical oncology Less
Keywords	Principal Investigator 代謝 / がん / PKM / NAD / がん代謝 / Pkm / ワールブルグ効果 / 解糖系 / スプライシング / プロテインホスファターゼ … More / シグナル伝達 / 鉄硫黄クラスター / 腫瘍免疫 / がんターゲット治療 / Pkm2 / 小細胞肺がん / Pkm1 / がん細胞の特性 / オートファジー / グルコース代謝 / splicing / RNA / NIPP1 / PP1 / RNAプロセッシング / PTPεC / チロシンホスファターゼ / サイトカイン … More Except Principal Investigator 代謝 / ワールブルグ効果 / PP1 / スプライシング / プロテインホスファターゼ / 解糖系 / PKM / PP2A / PTPεC / がん / グリオーマ / 低酸素 / チロシンホスファターゼ / 標的治療 / 卵巣がん / Pkm / siRNA / tautomycetin / トウトマイセチン / 肺がん / 解糖系酵素 / MKP7 / LDP4 / 肺癌 / pp32 / 癌化 / PTPε / IL-6 / 腫瘍免疫 / 小細胞肺がん / Pkm2 / Pkm1 / SET / I-2^<PP2A> / I-1^<PP2A> / TCPTP / Aurora kinase / GSK3β / MAPK / LDP / JNK / Raf-1 / LDP-3 / MKP-7 / NIPP-1 / phosphatase / kinase / phosphorylation / 細胞増殖 / S6キナーゼ / トートマイセチン / ホスファターゼ / キナーゼ / リン酸化 / S6 / トウトマイシン / 大腸がん / DNA修復 / 分子標的治療 / モノクロナル抗体 / 遺伝子発現 / 化学療法 / ERK / 組織バンク / 呼吸器外科学 / 翻訳 / NIPP1 / 転移抑制 / トランスジェニックマウス / アポトーシス / 細胞分化 / 腫瘍免役 / ノックアウト / 鉄 / ビタミンC / 食事療法 / 栄養 / 食事 / ナイアシン / ビタミン / BRCA / 治療 / 鉄硫黄クラスター / 抗がん剤 / 細胞老化 / がん細胞の特性 / グルコース代謝 / NAD代謝 / 浸透圧刺激 / ユビキチン / MAPKホスファターゼ / 中心体 / ビメンチン / 阻害剤 / manzamenone / PTP1B / T-cell PTP / オーロラキナーゼ / MARK / dephosphorylation / gsk3b / raf / 脱リン酸化 / ストレス応答 / M1細胞 / JNKホスファターゼ / Raf / インヒビター2 / B-Raf / DSP / calcineurin / 免疫抑制 / 細胞周期 / がん化 / 欠損マウス / カルシニューリン / apoptosis / cell differentiation / dual specificity phosphatase / phosphotyrosine phosphatase / protein phosphatase / 2重特異性ホスファターゼ / インヒビター4 / 2重基質特異性ホスファタ-ゼ / セリンホスファタ-ゼ / チロシンホスファタ-ゼ / 二重基質特異性ホスファターゼ / ゲノム不安定性 / 低栄養 / 癌代謝 / ピルビン酸キナーゼ / 膵癌 / 代謝異常 / 遺伝子情報 / 大腸癌 / FDG-PET / 非小細胞肺がん / 診断法 / 脳腫瘍学 / 中心体制御 / PP6 / β-catenin / N-Cadherin / KIF3A / Dusp26 / 細胞死 / モータータンパク / 細胞間接着 / 癌 / DUSP26 / SAP155 / HRM / 早期肺癌 / 前癌病変 / 遺伝子変異 / 遺伝子発現異常 / MAPK経路 / KIF3モーター / 細胞内トランスポート / mRNA / クロマチンリモデリング活性 / 結合蛋白 / クロマチン免疫沈降法 / FHAドメイン / 転写 / 腫瘍原性 / 腫瘍現性 / IL-10 Less

卵巣がんの鉄・硫黄代謝を標的とする新規ターゲット治療の開発
- Principal Investigator
  
  山田秀和
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
小細胞肺がんの代謝脆弱性に着目した新規治療
- Principal Investigator
  
  盛田麻美
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
悪性神経膠腫における鉄関連メタボリズムの役割
- Principal Investigator
  
  山下洋二
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
がん代謝と自然免疫シグナル伝達経路のミッシングリンクPrincipal Investigator
- Principal Investigator
  
  田沼延公
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
がんの代謝脆弱性をターゲットする新規治療とメカニズムPrincipal Investigator
- Principal Investigator
  
  田沼延公
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
腫瘍細胞のグルコース代謝と免疫シグナルの相互作用
- Principal Investigator
  
  佐藤卓
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Targeting metabolic vulnerability of ovarian cancer
- Principal Investigator
  
  Yamada Hidekazu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Escape from energy/NAD-interdependence in malignant cancersPrincipal Investigator
- Principal Investigator
  
  Tanuma Nobuhiro
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Nutritional approach for activation of tumor immunity: mechanisms and therapeutic applications
- Principal Investigator
  
  Ito Shigemi
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
The yin and yang of the Warburg effect of tumors.Principal Investigator
- Principal Investigator
  
  Tanuma Nobuhiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
A novel molecularly-targeted therapy for IDH-mutant gliomas.
- Principal Investigator
  
  Yamashita Youji
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Metabolisms in BRCA-deficient and -proficient ovarian cancer as new therapeutic and diagnostic target.
- Principal Investigator
  
  Yamada Hidekazu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Molecular mechanisms by which PKM1, reversing the Warburg effect, promotes tumor cell growth.Principal Investigator
- Principal Investigator
  
  Tanuma Nobuhiro
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Tumor biology and related fields
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Tageting the PKM1-NAD metabolic axis in small cell lung cancer
- Principal Investigator
  
  Ito Shigemi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Active glucose metabolism and tumor promotion mediated by Pkm1Principal Investigator
- Principal Investigator
  
  TANUMA Nobuhiro
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor biology
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Targeting metabolic reprograming during therapy-induced cellular senescence in tumor cells.
- Principal Investigator
  
  Sato Ikuro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Aerobic glucose metabolism and Pkm1 in small cell lung cancer.
- Principal Investigator
  
  ITO Shigemi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor biology
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Identification of PKM as a target for pancreatic cancer therapy
- Principal Investigator
  
  Yamamoto Kuniharu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Possible interplay between metabolism and genomic instability during epithelial oncogenesis
- Principal Investigator
  
  SHIIBA KENICHI
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Analysis of human samples for developing a novel therapy that target the Warburg effect
- Principal Investigator
  
  SATO IKURO
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Fluorescent live-imaging of the switching of pyruvate kinase isoforms during tumorigenesis
- Principal Investigator
  
  ITO SHIGEMI
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor biology
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Roles for pyruvate kinase M in metabolic rewiring during gliomagenesis
- Principal Investigator
  
  KATAKURA RYUICHI
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurosurgery
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Roles for pyruvate kinase M in tumorigenesisPrincipal Investigator
- Principal Investigator
  
  TANUMA NOBUHIRO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Possible interdependence between Warburg effect and genomic instability during colorectal cancer development
- Principal Investigator
  
  SHIIBA KENITI
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所)
Development of novel therapy targeting the Warburg effect of cancer
- Principal Investigator
  
  SATO Ikuro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Clinical oncology
- Research Institution
  Miyagi Cancer Center Research Institute
Aberrant pre-mRNA splicing that contributes to increased glycolysis in glioma
- Principal Investigator
  
  KATAKURA Ryuuichi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Miyagi Cancer Center Research Institute
Aberrant pre-mRNA splicinginvolved in increased fluxof glycolysis in non-small lung cancer
- Principal Investigator
  
  SATO Masami
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  Kagoshima University
Clinical importance of aberrant splicing of pre-mRNA encoding a glycolytic enzyme in colorectal cancer and its potential for diagnostic marker
- Principal Investigator
  
  SHIIBA Kenichi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所)
  Miyagi Cancer Center Research Institute
癌のワールブルグ効果に関連するスプライシング異常の意義と機序Principal Investigator
- Principal Investigator
  
  田沼延公
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Miyagi Cancer Center Research Institute
解糖系異常亢進を惹起する肺癌特異的スプライシングスイッチング‐新規診断法の開発‐
- Principal Investigator
  
  佐藤雅美
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Thoracic surgery
- Research Institution
  Kagoshima University
  Miyagi Cancer Center Research Institute
Therapeutic effect of the polymeric micellar antineoplastic drugs infused convection-enhanced delivery against intracranial rat glioma models
- Principal Investigator
  
  YAMASHITA Yoji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Miyagi Cancer Center Research Institute
Development of genetic diagnosis and drugs for lung cancer, based on protein phosphatase targeting
- Principal Investigator
  
  SATO Masami
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  Miyagi Cancer Center Research Institute
Regulation of cell function by protein phosphatases
- Principal Investigator
  
  SHIMA Hiroshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Miyagi Cancer Center Research Institute
mRNA翻訳効率に対する転写過程での刷り込み現象
- Principal Investigator
  
  SHIMA Hiroshi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  Miyagi Cancer Center Research Institute
遺伝子発現の転写後調節におけるプロテインホスファターゼPP1の役割Principal Investigator
- Principal Investigator
  
  田沼延公
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Molecular biology
- Research Institution
  Miyagi Cancer Center Research Institute
  Hokkaido University
Regulation of cell function by protein dephosphorylation
- Principal Investigator
  
  SHIMA Hiroshi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Miyagi Cancer Center Research Institute
  Hokkaido University
チロシンホスファターゼPTPεCのがん抑制機構
- Principal Investigator
  
  菊池九二三
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
チロシンホスファターゼPTPεCのがん関連分子としての意義の解明
- Principal Investigator
  
  菊池九二三
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
チロシンホスファターゼによるサイトカインシグナル伝達の抑制機構Principal Investigator
- Principal Investigator
  
  田沼延公
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hokkaido University
Molecular mechanisms and their significance of protein phosphatase families which control the network-system of signal transduction
- Principal Investigator
  
  KIKUCHI Kunimi
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  HOKKAIDO UNIVERSITY
Regulation of translation by protein phosphorylation.
- Principal Investigator
  
  SHIMA Hiroshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  HOKKAIDO UNIVERSITY
発生やがん化に及ぼす内因性Jak-STAT阻害性ホスファターゼPTPεCの役割
- Principal Investigator
  
  KIKUCHI Kunimi
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
Regulatgion of translation by protein phosphorylation.
- Principal Investigator
  
  SHIMA Hiroshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  HOKKAIDO UNIVERSITY
Studies on control mechanism of protein phosphatases ds a network system of information
- Principal Investigator
  
  KIKUCHI Kunimi
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  HOKKAIDO UNIVERSITY

[Journal Article] Niacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma.2023
- Author(s)
  Nomura M, Ohuchi M, Sakamoto Y, Kudo K, Yaku K, Soga T, Sugiura Y, Morita M, Hayashi K, Miyahara S, Sato T, Yamashita Y, Ito S, Kikuchi N, Sato I, Saito R, Yaegashi N, Fukuhara T, Yamada H, Shima H, Nakayama KI, Hirao A, Kawasaki K, Arai Y, Akamatsu S, Tanuma S, Sato T, Nakagawa T and Tanuma N.
- Journal Title
  
  Nature Communications.
  
  Volume: 14(1) Issue: 1 Pages: 8095-8095
- DOI
  10.1038/s41467-023-43630-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09482, KAKENHI-PROJECT-21K11593, KAKENHI-ORGANIZER-23H04939, KAKENHI-PROJECT-22H04995, KAKENHI-PROJECT-23K24762, KAKENHI-PROJECT-23K27437
[Journal Article] PP6 deficiency in mice with KRAS mutation and Trp53 loss promotes early death by PDAC with cachexia-like features.2022
- Author(s)
  Fukui K, Nomura M, Kishimoto K, Tanuma N, Kurosawa K, Kanazawa K, Kato H, Sato T, Miura S, Miura K, Sato I, Tsuji H, Yamashita Y, Tamai K, Watanabe T, Yasuda J, Tanaka T, Satoh K, Furukawa T, Jingu K, Shima H.
- Journal Title
  
  Cancer Sci.
  
  Volume: 印刷中 Issue: 5 Pages: 1613-1624
- DOI
  10.1111/cas.15315
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09469, KAKENHI-PROJECT-20K06545, KAKENHI-PROJECT-21K19420, KAKENHI-PROJECT-21K19748, KAKENHI-PROJECT-21K07111, KAKENHI-PROJECT-20K07436, KAKENHI-PROJECT-21K15425, KAKENHI-PROJECT-21K16852
[Journal Article] Ppp6c deficiency accelerates K-rasG12D -induced tongue carcinogenesis.2021
- Author(s)
  Kishimoto K, Kanazawa K, Nomura M, Tanaka T, Shigemoto-Kuroda T, Fukui K, Miura K, Kurosawa K, Kawai M, Kato H, Terasaki K, Sakamoto Y, Yamashita Y, Sato I, Tanuma N, Tamai K, Kitabayashi I, Matsuura K, Watanabe T, Yasuda J, Tsuji H, Shima H.
- Journal Title
  
  Cancer Med.
  
  Volume: 10(13) Issue: 13 Pages: 4451-4464
- DOI
  10.1002/cam4.3962
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09109, KAKENHI-PROJECT-20K17365, KAKENHI-PROJECT-20K06545, KAKENHI-PROJECT-20K07436, KAKENHI-PROJECT-21K19420, KAKENHI-PROJECT-21K19748, KAKENHI-PROJECT-21K15425
[Journal Article] Ppp6c haploinsufficiency accelerates UV-induced BRAF(V600E)-initiated melanomagenesis.2021
- Author(s)
  Kanazawa K, Kishimoto K, Nomura M, Kurosawa K, Kato H, Inoue Y, Miura K, Fukui K, Yamashita Y, Sato I, Tsuji H, Watanabe T, Tanaka T, Yasuda J, Tanuma N, Shima H
- Journal Title
  
  Cancer Sci.
  
  Volume: in press Issue: 6 Pages: 2233-2244
- DOI
  10.1111/cas.14895
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09469, KAKENHI-PROJECT-19K18757, KAKENHI-PROJECT-20K17365, KAKENHI-PROJECT-20K06545, KAKENHI-PROJECT-20K07436, KAKENHI-PROJECT-21K15425
[Journal Article] Divergent metabolic responses dictate vulnerability to NAMPT inhibition in ovarian cancer2020
- Author(s)
  Kudo Kei、Nomura Miyuki、Sakamoto Yoshimi、Ito Shigemi、Morita Mami、Kawai Masaaki、Yamashita Yoji、Ito Kiyoshi、Yamada Hidekazu、Shima Hiroshi、Yaegashi Nobuo、Tanuma Nobuhiro
- Journal Title
  
  FEBS Letters
  
  Volume: 594 Issue: 9 Pages: 1379-1388
- DOI
  10.1002/1873-3468.13736
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09469, KAKENHI-PROJECT-17K07187, KAKENHI-PROJECT-19K09109, KAKENHI-PROJECT-18K09243, KAKENHI-PROJECT-17K07231, KAKENHI-PROJECT-18K15965
[Journal Article] Novel activating KRAS mutation candidates in lung adenocarcinoma2020
- Author(s)
  Abe Jiro、Tanuma Nobuhiro、Nomura Miyuki、Ito Shin、Kasugai Isao、Sato Ikuro、Tamai Keiichi、Mochizuki Mai、Yamaguchi Kazunori、Shima Hiroshi、Okada Yoshinori、Yasuda Jun
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 522 Issue: 3 Pages: 690-696
- DOI
  10.1016/j.bbrc.2019.11.151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07187, KAKENHI-PROJECT-17K07193, KAKENHI-PROJECT-17K07231
[Journal Article] ワールブルグ効果について，PKMノックインモデルを通してもう一度見つめなおす2019
- Author(s)
  田沼延公
- Journal Title
  
  生化学
  
  Volume: 91 Pages: 38-43
- Data Source
  KAKENHI-PROJECT-17K19620
[Journal Article] ピルビン酸キナーゼMのアイソフォームPkm1はがんの増殖を細胞自律的に促進する2018
- Author(s)
  盛田麻美・佐藤卓・田沼延公
- Journal Title
  
  First Author's
  
  Volume: - Pages: 038
- DOI
  10.7875/first.author.2018.038
- Data Source
  KAKENHI-PROJECT-18K15965, KAKENHI-PROJECT-17K19620
[Journal Article] Revisiting glucose metabolism in cancer: lessons from a PKM knock-in model.2018
- Author(s)
  Sato T, Morita M, Nomura M, Tanuma N
- Journal Title
  
  Mol Cell Oncol
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19620
[Journal Article] PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth.2018
- Author(s)
  M Morita, T Sato, M Nomura, Y Sakamoto, Y Inoue, R Tanaka, S Ito, K Kurosawa, K Yamaguchi, Y Sugiura, H Takizaki, Y Yamashita, R Katakura, I Sato, Y Okada, H Watanabe, G Kondoh, et al.
- Journal Title
  
  Cancer Cell
  
  Volume: 12 Issue: 3 Pages: 355-367
- DOI
  10.1016/j.ccell.2018.02.004
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07296, KAKENHI-PROJECT-16K09597, KAKENHI-PROJECT-16K10486, KAKENHI-PROJECT-17K19620, KAKENHI-PROJECT-17K16876, KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-16H04730, KAKENHI-PROJECT-15K09237, KAKENHI-PROJECT-15K21098, KAKENHI-PROJECT-16K19745, KAKENHI-PROJECT-17K07187, KAKENHI-PUBLICLY-17H05534, KAKENHI-PUBLICLY-17H06011, KAKENHI-PROJECT-16K10774, KAKENHI-PROJECT-17K19606, KAKENHI-PLANNED-17H06301, KAKENHI-PROJECT-16K07187, KAKENHI-PROJECT-17K07231
[Journal Article] A metabolic vulnerability of small-cell lung cancer2018
- Author(s)
  Nomura Miyuki、Morita Mami、Tanuma Nobuhiro
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 64 Pages: 32278-32279
- DOI
  10.18632/oncotarget.25964
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16876, KAKENHI-PROJECT-17K07231, KAKENHI-PROJECT-17K19620
[Journal Article] Loss of protein phosphatase 6 in mouse keratinocytes enhances K-ras G12D -driven tumor promotion2018
- Author(s)
  Kurosawa Koreyuki、Inoue Yui、Kakugawa Yoichiro、Yamashita Yoji、Kanazawa Kosuke、Kishimoto Kazuhiro、Nomura Miyuki、Momoi Yuki、Sato Ikuro、Chiba Natsuko、Suzuki Mai、Ogoh Honami、Yamada Hidekazu、Miura Koh、Watanabe Toshio、Tanuma Nobuhiro、Tachi Masahiro、Shima Hiroshi
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 7 Pages: 2178-2187
- DOI
  10.1111/cas.13638
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07187, KAKENHI-PROJECT-17K10660, KAKENHI-PROJECT-18K16043, KAKENHI-PROJECT-16H04690, KAKENHI-PROJECT-16K07296, KAKENHI-PROJECT-16K10486, KAKENHI-PROJECT-16K10774, KAKENHI-PROJECT-17K16358, KAKENHI-PROJECT-17K16876, KAKENHI-PROJECT-18K09243, KAKENHI-PROJECT-16K07187, KAKENHI-PROJECT-17K19620
[Journal Article] Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics2017
- Author(s)
  Akaike Takaaki、、、Nishida Motohiro（4）、、、、、、Fujii Shigemoto（20）、、、Motohashi Hozumi（26）
- Journal Title
  
  Nature Communications
  
  Volume: 8 Issue: 1 Pages: 1177-1177
- DOI
  10.1038/s41467-017-01311-y
- NAID
  120007134656
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0013, KAKENHI-PROJECT-16K09398, KAKENHI-PROJECT-17K07187, KAKENHI-PROJECT-17K08619, KAKENHI-PROJECT-17K19205, KAKENHI-PROJECT-17K19508, KAKENHI-PROJECT-17K19620, KAKENHI-PROJECT-17K15408, KAKENHI-PROJECT-17K15464, KAKENHI-PROJECT-17K17583, KAKENHI-INTERNATIONAL-15K21759, KAKENHI-PLANNED-26110003, KAKENHI-ORGANIZER-26111001, KAKENHI-PLANNED-26111008, KAKENHI-PLANNED-26111011, KAKENHI-PROJECT-17H06170, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15H03115, KAKENHI-PROJECT-15H04335, KAKENHI-PROJECT-15H04692, KAKENHI-PROJECT-16H04674, KAKENHI-PROJECT-17F17116, KAKENHI-PROJECT-15K08178, KAKENHI-PROJECT-15K08456, KAKENHI-PROJECT-16K13089, KAKENHI-PROJECT-16K15208, KAKENHI-PROJECT-15K20855, KAKENHI-PROJECT-15K20857, KAKENHI-PROJECT-15K20876, KAKENHI-PLANNED-26116005, KAKENHI-PROJECT-16H05092
[Journal Article] Ex vivo model of non-small cell lung cancer using mouse lung epithelial cells.2017
- Author(s)
  Sato T, Morita M, Tanaka R, Inoue Y, Nomura M, Sakamoto Y, Miura K, Ito S, Sato I, Tanaka N, Abe J, Takahashi S, Kawai M, Sato M, Hippo Y, Shima H, Okada Y, Tanuma N
- Journal Title
  
  Oncol Lett.
  
  Volume: 14(6) Pages: 6863-6868
- DOI
  10.3892/ol.2017.7098
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10486, KAKENHI-PROJECT-17K07187, KAKENHI-PROJECT-17K10660, KAKENHI-PROJECT-17K10796, KAKENHI-PROJECT-17K19620, KAKENHI-PROJECT-17K19624, KAKENHI-PROJECT-17K16876, KAKENHI-PROJECT-16K19745
[Journal Article] Enhanced expression of PKM2 is involved in the gastric cancer development via regulating cancer specific metabolism.2017
- Author(s)
  Shiroki T, Yokoyama M, Tanuma N, Maejima R, Tamai K, Yamaguchi K, Oikawa T, Noguchi T, Miura K, Fujiya T, Shima H, Sato I, Kamiya N, Hatakeyama M, Iijima K, Shimosegawa T and Satoh K.
- Journal Title
  
  Cancer Science
  
  Volume: 印刷中 Issue: 5 Pages: 931-940
- DOI
  10.1111/cas.13211
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430130, KAKENHI-PROJECT-26461967, KAKENHI-PROJECT-26462077, KAKENHI-PROJECT-15K19080, KAKENHI-PROJECT-16K08773, KAKENHI-PROJECT-17K07187, KAKENHI-PROJECT-17K10660, KAKENHI-PROJECT-17K19620, KAKENHI-PROJECT-16H06373, KAKENHI-PROJECT-16K15273, KAKENHI-PROJECT-16K07132
[Journal Article] Abrogation of protein phosphatase 6 promotes skin carcinogenesis induced by DMBA2015
- Author(s)
  Hayashi K, Momoi Y , Tanuma N, Kishimoto A, Ogoh H, Kato H, Suzuki M, Sakamoto Y, Inoue Y, Nomura M, Kiyonari H, Sakayori M, Fukamachi K, Kakugawa Y, Yamashita Y, Ito S, Sato I, Suzuki A, Nishio M, Suganuma M, Watanabe T, and Shima H
- Journal Title
  
  Oncogene
  
  Volume: 印刷中 Issue: 35 Pages: 4647-55
- DOI
  10.1038/onc.2014.398
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24570159, KAKENHI-PROJECT-24591928, KAKENHI-PROJECT-25861168, KAKENHI-PROJECT-15K10081, KAKENHI-PROJECT-26430130, KAKENHI-PROJECT-15K19081, KAKENHI-PROJECT-15K20237, KAKENHI-PROJECT-25430163
[Journal Article] Loss of protein phosphatase 6 in mouse keratinocytes increases susceptibility to ultraviolet-B-induced carcinogenesis.2015
- Author(s)
  Kato H, Kurosawa K, Inoue Y, Tanuma N, Momoi Y, Hayashi K, Ogoh H, Nomura M, Sakayori M, Kakugawa Y, Yamashita Y, Miura K, Maemondo M, Katakura R, Ito S, Sato M, Sato I, Chiba N, Watanabe T, Shima H.
- Journal Title
  
  Cancer Lett.
  
  Volume: 365 Issue: 2 Pages: 223-228
- DOI
  10.1016/j.canlet.2015.05.022
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09237, KAKENHI-PROJECT-15K10081, KAKENHI-PROJECT-26430130, KAKENHI-PROJECT-26461967, KAKENHI-PROJECT-15K14387, KAKENHI-PROJECT-15K19081, KAKENHI-PROJECT-15K20237, KAKENHI-PROJECT-25430163, KAKENHI-PROJECT-25670609
[Journal Article] 発がんにおけるPKMスイッチ-意義と分子機構2012
- Author(s)
  田沼延公
- Journal Title
  
  実験医学　特集「がんと代謝」
  
  Volume: 30 Pages: 42-47
- Data Source
  KAKENHI-PROJECT-23650629
[Journal Article] 総説:PKMスイッチと発がん2012
- Author(s)
  田沼延公
- Journal Title
  
  実験医学増刊「がんと代謝」
  
  Volume: (印刷中)(未定)
- Data Source
  KAKENHI-PROJECT-22700893
[Journal Article] Roles and mechanisms for PKM swtich during tumorigenesis and cancer development.2012
- Author(s)
  Nobuhiro Tanuma
- Journal Title
  
  Jikken Igaku‘‘metabolisms in cancer’’(ed.:Esumi H.and Soga M.,Yodo-sya,Tokyo)
  
  Volume: 未定
- Data Source
  KAKENHI-PROJECT-23650629
[Journal Article] 発がんにおけるPKMスイッチ-意義と分子機構2012
- Author(s)
  田沼延公
- Journal Title
  
  実験医学特集「がんと代謝」
  
  Volume: Vol. 30、No. 15 Pages: 42-47
- Data Source
  KAKENHI-PROJECT-23650629
[Journal Article] Novel function of MKP-5/DUSP10, a phosphatase of stress-activated kinases, on ERK-dependent gene expression, and upregulation of its gene expression in colon carcinomas2012
- Author(s)
  Nomura M, Shiiba K, Katagiri C, Kasugai I, Masuda K, Sato I, Sato M, Kakugawa Y, Nomura E, Hayashi K, Nakamura Y, Nagata T, Otsuka T, Katakura R, Yamashita Y, Sato M, Tanuma N, Shima H
- Journal Title
  
  Oncol Rep
  
  Volume: 28(3) Pages: 931-6
- DOI
  10.3892/or.2012.1862
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390272
[Journal Article] 発がんにおけるPKMスイッチ-意義と分子機構2012
- Author(s)
  田沼延公
- Journal Title
  
  実験医学　特集「がんと代謝」
  
  Volume: 30 Pages: 42-47
- Data Source
  KAKENHI-PROJECT-23659700
[Journal Article] Novel function of MKP-5/DUSP10, a phosphatase of stress-activated kinases, on ERK-dependent gene expression, and upregulation of its gene expression in colon carcinomas2012
- Author(s)
  Nomura M, Shiiba K, Katagiri C, Kasugai I, Masuda K, Sato I, Sato M, Kakugawa Y, Nomura E, Hayashi K, Nakamura Y, Nagata T, Otsuka T, Katakura R, Yamashita Y, Sato M, Tanuma N, Shima H
- Journal Title
  
  Oncol Rep.
  
  Volume: 28(3) Pages: 931-6
- Data Source
  KAKENHI-PROJECT-23659700
[Journal Article] Novel function of MKP-5/DUSP10, a phosphatase for stress-activated kinases, on ERK dependent gene expression, and up-regulation of its gene expression in colon carcinomas2012
- Author(s)
  Ikuro Sato,Nobuhiro Tanuma
- Journal Title
  
  Oncology Reports
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650629
[Journal Article] H:Novel function of MKP-5/DUSP10, a phosphatase of stress-activated kinases, on ERK-dependent gene expression, and upregulation of its gene expression in colon carcinomas2012
- Author(s)
  Nomura M, Shiiba K, Katagiri C, Kasugai I, Masuda K, Sato I, Sato M, Kakugawa Y, Nomura E, Hayashi K, Nakamura Y, Nagata T, Otsuka T, Katakura R, Yamashita Y, Sato M, Tanuma N, Shima H
- Journal Title
  
  Oncol Rep.
  
  Volume: 28(3) Pages: 931-6
- Data Source
  KAKENHI-PROJECT-23650629
[Journal Article] 発がんにおけるPKMスイッチ-意義と分子機構2012
- Author(s)
  田沼延公
- Journal Title
  
  実験医学特集「がんと代謝」
  
  Volume: Vol. 30、No. 15 Pages: 42-47
- Data Source
  KAKENHI-PROJECT-23659700
[Journal Article] 発がんにおけるPKMスイッチ-意義と分子機構2012
- Author(s)
  田沼延公
- Journal Title
  
  実験医学　特集「がんと代謝」
  
  Volume: 30 Pages: 42-47
- Data Source
  KAKENHI-PROJECT-24501326
[Journal Article] 発がんにおけるPKMスイッチ-意義と分子機構2012
- Author(s)
  田沼延公
- Journal Title
  
  実験医学　特集「がんと代謝」
  
  Volume: 30 Pages: 42-47
- Data Source
  KAKENHI-PROJECT-24659621
[Journal Article] 発がんにおけるPKMスイッチ-意義と分子機構2012
- Author(s)
  田沼延公
- Journal Title
  
  実験医学特集「がんと代謝」
  
  Volume: Vol.30、No.15 Pages: 42-47
- Data Source
  KAKENHI-PROJECT-22390272
[Journal Article] Novel function of MKP-5/DUSP10, a phosphatase for stress-activated kinases, on ERK dependent gene expression, and up-regulation of its gene expression in colon carcinomas2012
- Author(s)
  Ryuichi Katakura,Nobuhiro Tanuma
- Journal Title
  
  Oncology Reports
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659700
[Journal Article] 発がんにおけるPKMスイッチ-意義と分子機構2012
- Author(s)
  田沼延公
- Journal Title
  
  実験医学　特集「がんと代謝」
  
  Volume: 30 Pages: 42-47
- Data Source
  KAKENHI-PROJECT-22390272
[Journal Article] DUSP13B/TMDP inhibits stress-activated MAPKs and suppresses AP-1-dependent gene expression2011
- Author(s)
  Chiaki Katagiri, Kenichi Shiiba, Nobuhiro Tanuma
- Journal Title
  
  Molecular and Cellular Biochemistry
  
  Volume: 352巻 Pages: 155-162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659248
[Journal Article] DUSP13B/TMDP inhibits stress-activated MAPKs and suppresses AP-1-dependent gene expression2011
- Author(s)
  Katagiri C, Masuda K, Nomura M, Tanoue K, Fujita S, Yamashita Y, Katakura R, Shiiba K, Nomura E, Sato M, Tanuma N, Shima H
- Journal Title
  
  Mol Cell Biochem
  
  Volume: 352(1-2) Issue: 1-2 Pages: 155-62
- DOI
  10.1007/s11010-011-0749-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390272, KAKENHI-PROJECT-23650629, KAKENHI-PROJECT-23659700
[Journal Article] DUSP13B/TMDP inhibits stress-activated MAPKs and suppresses AP-1-dependent gene expression2011
- Author(s)
  Ryuichi Katakura,Nobuhiro Tanuma
- Journal Title
  
  Molecular and Cellular Biochemistry
  
  Volume: 352 Pages: 155-162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659700
[Journal Article] CDC25A mRNA levels significantly correlate with Ki-67 expression in h uman glioma samples2010
- Author(s)
  Yoji Yamashita, Nobuhiro Tanuma
- Journal Title
  
  Journal of Neuro-Oncology
  
  Volume: 100巻 Pages: 43-49
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659248
[Journal Article] MKP-7, a JNK phosphatase, blocks ERK-dependent gene activation by anchoring phosphorylated ERK in the cytoplasm.2010
- Author(s)
  Masuda K, Katagiri C, Nomura M, Sato M, Kakumoto K, Akagi T, Kikuchi K, Tanuma N, Shima H.
- Journal Title
  
  Biochem Biophys Res Commun 393
  
  Pages: 201-206
- Data Source
  KAKENHI-PROJECT-19390370
[Journal Article] CDC25A mRNA levels significantly correlate with Ki-67 expression in human glioma samples.2010
- Author(s)
  Yamashita Y, Kasugai I, Sato M, Tanuma N, Sato I, Nomura M, Yamashita K, Sonoda Y, Kumabe T, Tominaga T, Katakura R, Shima H
- Journal Title
  
  J Neurooncol 100
  
  Pages: 43-49
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591730
[Journal Article] MKP-7, a JNK phosphatase, blocks ERK-dependent gene activation by anchoring phosphorylated ERK in the cytoplasm2010
- Author(s)
  Masuda K, Katagiri C, Nomura M, Sato M, Kakumoto K, Akagi T, Kikuchi K, Tanuma N, Shima H
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 393(2) Issue: 2 Pages: 201-6
- DOI
  10.1016/j.bbrc.2010.01.097
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390272
[Journal Article] The phosphatase interactor NIPP1 regulates the occupancy of the histone methyltransferase EZH2 at Polycomb targets2010
- Author(s)
  Nele Van Dessel, Nobuhiro Tanuma
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 38巻 Pages: 7500-7512
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659248
[Journal Article] CDC25A mRNA levels significantly correlate with Ki-67 expression in human glioma samples2010
- Author(s)
  Yamashita Y, Kasugai I, Sato M, Tanuma N, Sato I, Nomura M, Yamashita K, Sonoda Y, Kumabe T, Tominaga T, Katakura R, Shima H
- Journal Title
  
  J Neuroncol
  
  Volume: 100 Issue: 1 Pages: 43-4
- DOI
  10.1007/s11060-010-0147-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390272
[Journal Article] MKP-7, a JNK phosphatase, blocks ERK-dependent gene activation by anchoring phosphorylated ERK in the cytoplasm2010
- Author(s)
  Kouhei Masuda, Nobuhiro Tanuma
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 393巻 Pages: 201-206
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659248
[Journal Article] Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion2009
- Author(s)
  Tanuma N
- Journal Title
  
  Oncogene 28
  
  Pages: 752-761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570142
[Journal Article] Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion2009
- Author(s)
  Tanuma N, Sato M, et al.
- Journal Title
  
  Oncogene 28巻
  
  Pages: 752-761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390370
[Journal Article] Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediaded cell-cel adhesion.2009
- Author(s)
  Tanuma N, Nomura M, Ikdea M, Kusugai I, Tsubaki Y, Takagaki K, Kawamura T, Yamashita Y, Sato I, Sato M, Katakura R, Kikuchi K, Shima H
- Journal Title
  
  Oncogene 28
  
  Pages: 752-76
- Data Source
  KAKENHI-PROJECT-19390370
[Journal Article] Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion.2009
- Author(s)
  Tanuma N, Nomura M, Ikeda M, Kasugai I, Tsubaki Y, Takagaki K, Kawamura T, Yamashita Y, Sato I, Sato M, Katakura R, Kikuchi K, Shima H
- Journal Title
  
  Oncogene 28
  
  Pages: 752-761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591730
[Journal Article] Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion2009
- Author(s)
  Tanuma N, Sato M, et al.
- Journal Title
  
  Oncogene 28巻
  
  Pages: 752-761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659333
[Journal Article] Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion2009
- Author(s)
  Tanuma N
- Journal Title
  
  Oncogene 28巻
  
  Pages: 752-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591730
[Journal Article] Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion.2009
- Author(s)
  Tanuma N, Nomura M, Ikeda M, Kasugai I, Tsubaki Y, Takagaki K,Kawamura T, Yamashita Y, Sato I, Sato M, Katakura R, Kikuchi K, Shima H.
- Journal Title
  
  Oncogene 28
  
  Pages: 752-761
- Data Source
  KAKENHI-PROJECT-19570142
[Journal Article] Nuclear inhibitor of protein phosphatase-1 (NIPP1) directs protein phosphatase-1 (PP1) to dephosphorylatethe U2 snRNP component, spliceosome-associated protein 155 (Sap155)2008
- Author(s)
  Tanuma N, Kim S-E, Beullens M, Tsubaki Y, Mitsuhashi S, Nomura M, Kawamura T, Isono K, Koseki H, Sato M, Bollen M, Kikuchi K, Shima H.
- Journal Title
  
  Journal of Biological Chemistry 283(51)
  
  Pages: 35805-35814
- Data Source
  KAKENHI-PROJECT-19570142
[Journal Article] Nuclear inhibitor of protein phosphatase-1 (NIPP1) directs protein phosphatase-1 (PP1) to dephosphorylate the U2 snRNP component, spliceosome-associated protein 155 (Sap155)2008
- Author(s)
  Tanuma N
- Journal Title
  
  J Biol Chem 283
  
  Pages: 35805-35814
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390370
[Journal Article] Nuclear inhibitor of protein phosphatase-1 (NIPP1) directs protein phosphatase-1 (PP1) to dephosphorylate the U2 snRNP component, spliceosome-associated protein 155 (Sap155)2008
- Author(s)
  Tanuma N
- Journal Title
  
  Journal of Biological Chemistry 283
  
  Pages: 35805-35814
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570142
[Journal Article] Tautomycetin suppresses the TNFa/NFkB pathway via inhibition of IKK activation2008
- Author(s)
  Mitsuhashi S, Shima H, Li Y, Tanuma N, Okamoto T, Kikuchi K, Ubukata M.
- Journal Title
  
  International Journal of Oncology 33(5)
  
  Pages: 1027-1035
- Data Source
  KAKENHI-PROJECT-19570142
[Journal Article] The NMR structure of the NIPP1 FHA domain2008
- Author(s)
  Kumeta H, Ogura K, Adachi S, Fujioka Y, Tanuma N, Kikuchi K, Inagaki F.
- Journal Title
  
  J Biomol NMR 40(3)
  
  Pages: 219-24
- Data Source
  KAKENHI-PROJECT-19570142
[Journal Article] Nuclear inhibitor of protein phosphatase-1 (NIPP1) directs protein phosphatase-1(PP1) to dephosphorylate the U2 small nuclesr ribonucleoprotein particle(snRNP)component2008
- Author(s)
  Tanuma N, Kim SE, Buellens M, Tsubaki Y, Mitsuhashi S, Nomura M, Kawamura T, Isono K, Koseki H, Sato M, Bollen M, Kikuchi K, Shima H
- Journal Title
  
  spliceosome-associated protein 155 (Sap155). J Biol Chem 52
  
  Pages: 35805-35814
- Data Source
  KAKENHI-PROJECT-19390370
[Journal Article] Characterization of a novel low-molecular-mass dual specificity phosphatase-4 (LDP-4) expressed in brain.2007
- Author(s)
  Takagaki K, Shima H, Tanuma N, Nomura M, Satoh T, Watanabe M, Kikuchi K.
- Journal Title
  
  Molecular and Cellular Biochemistry 296(1-2)
  
  Pages: 177-84
- Data Source
  KAKENHI-PROJECT-19570142
[Journal Article] Characterization of a novel low-molecular- mass dual specificity phosphatase-4(LDP-4) expressed in brain2006
- Author(s)
  Takagaki K, Shima H, Tanuma N, Nomura M, Satoh T, Watanabe M, Kikuchi K.
- Journal Title
  
  Mol Cell Biochem 296
  
  Pages: 177-184
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370055
[Journal Article] pp32/I-1^<PP2A> negatively regulates the Raf/MEK/ERK pathway.2005
- Author(s)
  Fukukawa C, Tanuma N, Okada T, Kikuchi K, Shima H.
- Journal Title
  
  Cancer Lett 226
  
  Pages: 155-160
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370055
[Journal Article] Protein phosphatase type 2A, PP2A, is involved in degradation of gp130.2005
- Author(s)
  Mitsuhashi S, Shima H, Tanuma N, Sasa S, Onoe K, Ubukata M, Kikuchi K
- Journal Title
  
  Molecular and Cellular Biochemistry 269
  
  Pages: 183-187
- Data Source
  KAKENHI-PROJECT-17770137
[Journal Article] pp32/ I-1(PP2A) negatively regulates the Raf-1/MEK/ERK pathway.2005
- Author(s)
  Fukukawa C, Tanuma N, Okada T, Kikuchi K, Shima H
- Journal Title
  
  Cancer Letters 226
  
  Pages: 155-160
- Data Source
  KAKENHI-PROJECT-17770137
[Journal Article] The oncoprotein I-2PP2A/SET negatively regulates the MEK/ERK pathway and cell proliferation.2005
- Author(s)
  Fukukawa C, Shima H, Tanuma N, Okada T, Kato N, Adachi Y, Kikuchi K
- Journal Title
  
  International Journal of Oncology 26
  
  Pages: 751-756
- Data Source
  KAKENHI-PROJECT-17770137
[Journal Article] Protein phosphatase type 2A, PP2A, is involved in degradation of gp130.2004
- Author(s)
  Mitsuhashi S, Shima H, Tanuma N, Sasa S, Onoe K, Ubukata M, Kikuchi K.
- Journal Title
  
  Mol Cell Biochem 269
  
  Pages: 183-187
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370055
[Journal Article] Analysis of isoform specific function of PP1 catalytic subunits in mammalian cells using siRNA.2004
- Author(s)
  Okada T, Fujii T, Tanuma N, Mitsuhashi S, Urano T, Araki Y, Shima H, Kikuchi K.
- Journal Title
  
  Int J Oncol 25
  
  Pages: 1383-1388
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370055
[Journal Article] Characterization of a novel low-molecular-mass dual-specificity phosphaase 3(LDP-3) that enhances activation of JNK and p38.2004
- Author(s)
  Takagaki K, Satoh T, Tanuma N, Masuda K, Takekawa M, Shima H, Kikuchi K.
- Journal Title
  
  Biochem J 383
  
  Pages: 447-455
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370055
[Journal Article] The oncoprotein I-2^<PP2A>/SET negatively regulates the MEK/ERK pathway and cell proliferation.2004
- Author(s)
  Fukukawa C, Shima H, Tanuma N, Okada T, Kato N, Adachi Y, Kikuchi K.
- Journal Title
  
  Int J Oncol 26
  
  Pages: 751-756
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370055
[Journal Article] Reduced tumorigenicity of murine leukemia cells expressing protein tyrosine phosphatase, PTPεC2003
- Author(s)
  Tanuma, Nobuhiro
- Journal Title
  
  Oncogene 22(12)
  
  Pages: 1758-1762
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14380299
[Journal Article] Novel function of MKP-5/DUSP10, a phosphatase for stress-activated kinases, on ERK dependent gene expression, and up-regulation of its gene expression in colon carcinomas
- Author(s)
  Miyuki Nomura, Kenichi Shiiba, Nobuhiro Tanuma
- Journal Title
  
  Oncology Reports
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659248
[Presentation] 鉄硫黄クラスター生合成欠損で腫瘍細胞に誘導された、細胞老化様の増殖停止2023
- Author(s)
  宮原周子、野村美有樹、大内麻衣、山田秀和、田沼延公
- Organizer
  日本生化学会東北支部第89回例会・シンポジウム
- Data Source
  KAKENHI-PROJECT-21K09482
[Presentation] 鉄硫黄クラスター欠損が卵巣癌細胞株にもたらす、細胞老化様の増殖停止2023
- Author(s)
  宮原周子、大内麻衣、野村美有樹、山田秀和、田沼延公
- Organizer
  第9回がんと代謝研究会2023 in 松山
- Data Source
  KAKENHI-PROJECT-21K09482
[Presentation] CRISPRスクリーニングによる、卵巣癌代謝ターゲットの探索2023
- Author(s)
  宮原周子、徳永英樹、島田宗昭、山田秀和、八重樫伸生、田沼延公
- Organizer
  第65回日本婦人科腫瘍学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K09482
[Presentation] FDX2欠損は卵巣がん細胞株に細胞老化様の増殖停止または細胞死をもたらす2023
- Author(s)
  宮原周子、大内麻衣、野村美有樹、橋本栄文、山下洋二、徳永英樹、島田宗昭、山田秀和、八重樫伸生、田沼延公
- Organizer
  第22回日本婦人科がん分子標的研究会
- Data Source
  KAKENHI-PROJECT-21K09482
[Presentation] 鉄硫黄クラスター生合成に異常をきたした細胞の表現型2023
- Author(s)
  宮原周子、野村美有樹、大内麻衣、林佳代子、山下洋二、徳永英樹、島田宗昭、山田秀和、田沼延公
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K09482
[Presentation] 「がん治療に食事が及ぼす効果」2023
- Author(s)
  田沼延公
- Organizer
  第26回日本病態栄養学会
- Invited
- Data Source
  KAKENHI-PROJECT-21K19420
[Presentation] Restriction of the dietary niacin enhances NAD-targeting therapy in mice2022
- Author(s)
  Miyuki Nomura, Tomoyoshi Soga, Shusuke Akamatsu, Mami Morita, Yoji Yamashita, Hiroshi Shima, Hidekazu Yamada, Taku Sato, Nobuhiro Tanuma
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K19420
[Presentation] Systemic niacin metabolism that limits efficacy of NAD-targeted therapy in cancer2022
- Author(s)
  野村美有樹、大内麻衣、伊藤しげみ、盛田麻美、菊池直彦、佐藤卓、中川崇、田沼延公
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K19420
[Presentation] Targeting NAD biogenesis in lung and prostate neuroendocrine carcinomas.2022
- Author(s)
  Nobuhiro Tanuma.
- Organizer
  第12回日米癌合同会議
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19420
[Presentation] NAD biogenesis is a targetable vulnerability of small-cell lung and prostate cancers2022
- Author(s)
  大内麻衣、宮原周子、野村美有樹、坂本良美、伊藤しげみ、盛田麻美、佐藤卓、菊池直彦、田沼延公
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K19420
[Presentation] Systemic niacin metabolism that limits efficacy of NAD-targeted therapy in cancer2022
- Author(s)
  野村美有樹、大内麻衣、伊藤しげみ、盛田麻美、菊池直彦、佐藤卓、中川崇、田沼延公
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K19748
[Presentation] NAD dependence of small-cell lung and prostate cancers2022
- Author(s)
  Nobuhiro Tanuma, Shuko Miya-hara, Miyuki Nomura, Tomoyoshi Soga, Shusuke Akamatsu, Mami Morita, Yoji Yamashita, Hiroshi Shima, Hidekazu Yamada, Taku Sato,
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K08989
[Presentation] NAD dependence of small-cell lung and prostate cancers2022
- Author(s)
  Nobuhiro Tanuma, Shuko Miya-hara, Miyuki Nomura, Tomoyoshi Soga, Shusuke Akamatsu, Mami Morita, Yoji Yamashita, Hiroshi Shima, Hidekazu Yamada, Taku Sato,
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K09482
[Presentation] Systemic niacin metabolism that limits efficacy of NAD-targeted therapy in cancer2022
- Author(s)
  野村美有樹、大内麻衣、伊藤しげみ、盛田麻美、菊池直彦、佐藤卓、中川崇、田沼延公
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K08989
[Presentation] NAD biogenesis is a targetable vulnerability of small-cell lung and prostate cancers2022
- Author(s)
  大内麻衣、宮原周子、野村美有樹、坂本良美、伊藤しげみ、盛田麻美、佐藤卓、菊池直彦、田沼延公
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K19748
[Presentation] NAD dependence of small-cell lung and prostate cancers2022
- Author(s)
  Nobuhiro Tanuma, Shuko Miya-hara, Miyuki Nomura, Tomoyoshi Soga, Shusuke Akamatsu, Mami Morita, Yoji Yamashita, Hiroshi Shima, Hidekazu Yamada, Taku Sato,
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K19420
[Presentation] NAD biogenesis is a targetable vulnerability of small-cell lung and prostate cancers2022
- Author(s)
  大内麻衣、宮原周子、野村美有樹、坂本良美、伊藤しげみ、盛田麻美、佐藤卓、菊池直彦、田沼延公
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K08989
[Presentation] Restriction of the dietary niacin enhances NAD-targeting therapy in mice2022
- Author(s)
  Miyuki Nomura, Tomoyoshi Soga, Shusuke Akamatsu, Mami Morita, Yoji Yamashita, Hiroshi Shima, Hidekazu Yamada, Taku Sato, Nobuhiro Tanuma
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K08989
[Presentation] Restriction of the dietary niacin enhances NAD-targeting therapy in mice2022
- Author(s)
  Miyuki Nomura, Tomoyoshi Soga, Shusuke Akamatsu, Mami Morita, Yoji Yamashita, Hiroshi Shima, Hidekazu Yamada, Taku Sato, Nobuhiro Tanuma
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K09482
[Presentation] 食事介入を活用したNAD高依存がんに対する代謝標的治療2022
- Author(s)
  田沼延公
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K19420
[Presentation] 食事中のNAD前駆体が、NAD標的治療の効果を限定するメカニズム2022
- Author(s)
  田沼延公
- Organizer
  第8回がんと代謝研究会
- Data Source
  KAKENHI-PROJECT-21K19420
[Presentation] Targeting NAD metabolism in cancer.2021
- Author(s)
  Tanuma N
- Organizer
  第80回日本癌学会学術集会 JCA-AACR Joint Symposia “Cancer Metabolism”（横浜）
- Invited
- Data Source
  KAKENHI-PROJECT-21K19420
[Presentation] Metabolism-targeting therapy and precision nutrition in cancer2021
- Author(s)
  Tanuma N
- Organizer
  第80回日本癌学会学術集会　モーニングレクチャー（横浜）
- Invited
- Data Source
  KAKENHI-PROJECT-21K19420
[Presentation] Targeting NAD metabolism in cancer.2021
- Author(s)
  Tanuma N
- Organizer
  第80回日本癌学会学術集会 JCA-AACR Joint Symposia “Cancer Metabolism”（横浜）
- Invited
- Data Source
  KAKENHI-PROJECT-21K19748
[Presentation] Metabolism-targeting therapy and precision nutrition in cancer2021
- Author(s)
  Tanuma N
- Organizer
  第80回日本癌学会学術集会　モーニングレクチャー（横浜）
- Invited
- Data Source
  KAKENHI-PROJECT-21K19748
[Presentation] がん代謝のシンボル、ワールブルグ効果の実体とは？2019
- Author(s)
  田沼延公
- Organizer
  愛媛大学プロテオサイエンスセンター第６回学術シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17K19620
[Presentation] アンチワールブルグ効果型の解糖系酵素Pkm1は、細胞自律的な機序で、がん促進的にはたらく2018
- Author(s)
  田沼延公
- Organizer
  第77回日本癌学会学術総会　JCA-AACR Joint Symposia
- Invited
- Data Source
  KAKENHI-PROJECT-17K19620
[Presentation] Revisiting glucose metabolism in cancer by a Pkm knock-in model2018
- Author(s)
  田沼延公
- Organizer
  金沢国際がん生物シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17K19620
[Presentation] Predominance of Pkm2 limits glucose metabolism and tumor development2017
- Author(s)
  Tanuma N
- Organizer
  2017　日本癌学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K19620
[Presentation] Pkm遺伝子改変から見えてきた、ワールブルグ効果の“がん抑制的”側面2017
- Author(s)
  田沼延公
- Organizer
  第5回　がんと代謝研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17K19620
[Presentation] ピルビン酸キナーゼM2(PKM2)と膵癌細胞増殖2016
- Author(s)
  1)横山美沙, 渋谷莉恵, 坂本良美, 田沼延公, 玉井恵一, 田中伸幸, 山口壹範, 菅村和夫, 佐藤賢一
- Organizer
  日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26462077
[Presentation] ピルビン酸キナーゼM2(PKM2)と膵癌細胞増殖第2016
- Author(s)
  1)横山美沙, 渋谷莉恵, 坂本良美, 田沼延公, 望月麻衣, 中村真央, 玉井恵一, 山口壹範, 田中伸幸, 菅村和夫, 佐藤賢一
- Organizer
  日本膵臓学会大会
- Place of Presentation
  仙台
- Year and Date
  2016-08-04
- Data Source
  KAKENHI-PROJECT-26462077
[Presentation] 皮膚Ppp6c欠損マウスは、UVB誘導皮膚扁平上皮発がんに高感受性となる2015
- Author(s)
  加藤浩之、田沼延公、三浦康、角川陽一郎、椎葉健一、山下洋二、林克剛、野村美有樹、佐藤郁郎、伊藤しげみ、渡邊利雄、島礼
- Organizer
  第74回　日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県・名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25430163
[Presentation] 皮膚Ppp6c欠損マウスは、UVB誘導皮膚扁平上皮発がんに高感受性となる2015
- Author(s)
  加藤浩之、田沼延公、三浦康、角川陽一郎、椎葉健一、山下洋二、林克剛、野村美有樹、佐藤郁郎、伊藤しげみ、渡邊利雄、島礼
- Organizer
  第74回　日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県・名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26670611
[Presentation] 紫外線誘導皮膚がんにおいて、PP6はがん抑制遺伝子として働く2015
- Author(s)
  黒沢是之、後藤孝浩、田沼延公、加藤浩之、佐藤郁郎、伊藤しげみ、島礼、館正弘
- Organizer
  第24回日本形成外科学会基礎学術集会
- Place of Presentation
  岩手県民会館（岩手県・盛岡市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25430163
[Presentation] 皮膚Ppp6c欠損マウスは、UVB誘導皮膚扁平上皮発がんに高感受性となる2015
- Author(s)
  加藤浩之、田沼延公、三浦康、角川陽一郎、椎葉健一、山下洋二、林克剛、野村美有樹、佐藤郁郎、伊藤しげみ、渡邊利雄、島礼
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県・名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K14387
[Presentation] 紫外線誘導皮膚がんにおいて、PP6はがん抑制遺伝子として働く2015
- Author(s)
  黒沢是之、後藤孝浩、田沼延公、加藤浩之、佐藤郁郎、伊藤しげみ、島礼、館正弘
- Organizer
  第24回日本形成外科学会基礎学術集会
- Place of Presentation
  岩手県民会館（岩手県・盛岡市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K14387
[Presentation] 発がんに伴う、Pyruvate Kinase Mのアイソザイム変換-代謝再プログラム化における意義解明のための新規マウスモデル2014
- Author(s)
  坂本良美、野村美有樹、松本祥子、盛田麻美、田中遼太、島礼、渡邊利雄、田沼延公
- Organizer
  第6回日本プロテインホスファターゼ研究会学術集会
- Place of Presentation
  津
- Year and Date
  2014-02-20
- Data Source
  KAKENHI-PROJECT-24659621
[Presentation] 発がんに伴う、Pyruvate Kinase Mのアイソザイム変換-代謝再プログラム化における意義解明のための新規マウスモデル2014
- Author(s)
  坂本良美、野村美有樹、松本祥子、盛田麻美、田中遼太、島礼、渡邊利雄、田沼延公
- Organizer
  第6回日本プロテインホスファターゼ研究会学術集会
- Place of Presentation
  三重
- Data Source
  KAKENHI-PROJECT-24501326
[Presentation] ノックインモデルを用いた、ピルビン酸キナーゼM（PKM）アイソフォームの機能解析2013
- Author(s)
  坂本良美、渡邊利雄、野村美有樹、山下洋二、椎葉健一、佐藤郁郎、佐藤雅美、島礼、田沼延公
- Organizer
  第72回日本癌学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25430163
[Presentation] PKMスイッチ不可能なマウスモデルの開発2013
- Author(s)
  田沼延公
- Organizer
  日本癌学会がん代謝シンポジウム
- Place of Presentation
  東京
- Year and Date
  2013-01-17
- Data Source
  KAKENHI-PROJECT-22390272
[Presentation] Roles for pyruvate kinase M (PKM) isoforms in tumor metabolism2013
- Author(s)
  Nobuhiro Tanuma
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸
- Invited
- Data Source
  KAKENHI-PROJECT-24501326
[Presentation] 「がんの代謝とピルビン酸キナーゼM-ノックインモデルを用いた解析」2013
- Author(s)
  田沼延公
- Organizer
  第15回がん・エピゲノム研究会
- Place of Presentation
  仙台
- Invited
- Data Source
  KAKENHI-PROJECT-24501326
[Presentation] Ptprz gene encoding a transmembrene-type protein phosphatase is up-regulated by Sox-2 in glioma.2013
- Author(s)
  Yoji Yamashita,Nobuhiro Tanuma,Ichiro Shibahara,Yukihiro Sonoda,Masayuki Kanamori,Ryuta Saito,Toshihiro Kumabe,Teiji Tominaga,Hiroshi Shima,Ryuichi Katakura
- Organizer
  AACR ANNUAL MEETING 2013
- Place of Presentation
  Washington,DC
- Data Source
  KAKENHI-PROJECT-25670627
[Presentation] Functions of pyruvate kinase M(PKM)isoforms in tumor development2013
- Author(s)
  Nobuhiro Tanuma
- Organizer
  第72回日本癌学会学術集会 Symposia"Cancer Cell Metabolism"
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-24501326
[Presentation] PKMスイッチ不可能なマウスモデルの開発2013
- Author(s)
  田沼延公
- Organizer
  日本癌学会がん代謝シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24501326
[Presentation] Pyruvate kinase type M2 (PKM2) is involved in human gastric cancer development2013
- Author(s)
  Shiroki T, Tanuma N, Sato I, Tanaka N, Sugamura K, Satoh K
- Organizer
  第72回日本癌学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2013-10-05
- Data Source
  KAKENHI-PROJECT-24659621
[Presentation] The pyruvate kinase type M2 (PKM2) expression is enhanced and induces cellular proliferation in human pancreatic cancer cells2013
- Author(s)
  横山美沙、渋谷利恵、白木健悠、田沼延公、玉井恵一、山口壹範、田中伸幸、菅村和夫、佐藤賢一
- Organizer
  第36回分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24501326
[Presentation] Generation of knock-in mice to dissect isoform-specific roles for each splicing isoform of pyruvate kinase M in vivo2013
- Author(s)
  松本祥子、坂本良美、野村美有樹、田中遼大、盛田麻美、伊藤しげみ、椎葉健一、野村栄樹、片倉隆一、山下洋二、佐藤郁郎、渡邊利雄、島礼、田沼延公
- Organizer
  第36回分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25670627
[Presentation] 「がんの代謝とピルビン酸キナーゼMによる制御機構」2013
- Author(s)
  田沼延公
- Organizer
  第6回Symphony
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24501326
[Presentation] PKMスイッチ不可能なマウスモデルの開発2013
- Author(s)
  田沼延公
- Organizer
  日本癌学会がん代謝シンポジウム
- Place of Presentation
  東京
- Year and Date
  2013-01-17
- Data Source
  KAKENHI-PROJECT-23650629
[Presentation] PKMアイソフォームに関する生理的、および病態生理的機能解析2013
- Author(s)
  坂本良美、松本祥子、渡邊利雄、近藤玄、野村美有樹、野村栄樹、椎葉健一、島礼、田沼延公
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24501326
[Presentation] Generation of knock-in mice to dissect isoform-specific roles for each splicing isoform of pyruvate kinase M in vivo2013
- Author(s)
  松本祥子、坂本良美、野村美有樹、田中遼大、盛田麻美、伊藤しげみ、椎葉健一、野村栄樹、片倉隆一、山下洋二、佐藤郁郎、渡邊利雄、島礼、田沼延公
- Organizer
  第36回分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24501326
[Presentation] PKMアイソフォームに関する生理的、および病態生理的機能解析2013
- Author(s)
  坂本良美、松本祥子、渡邊利雄、近藤玄、野村美有樹、野村栄樹、椎葉健一、島礼、田沼延公
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Year and Date
  2013-09-11
- Data Source
  KAKENHI-PROJECT-24659621
[Presentation] がんの代謝とピルビン酸キナーゼMによる制御機構2013
- Author(s)
  田沼延公
- Organizer
  第6回Symphony
- Place of Presentation
  東京
- Year and Date
  2013-09-22
- Data Source
  KAKENHI-PROJECT-24659621
[Presentation] PKMスイッチ不可能なマウスモデルの開発2013
- Author(s)
  田沼延公
- Organizer
  日本癌学会がん代謝シンポジウム
- Place of Presentation
  東京
- Year and Date
  2013-01-17
- Data Source
  KAKENHI-PROJECT-23659700
[Presentation] Pyruvate kinase type M2(PKM2)is involved in human gastric cancer development.2013
- Author(s)
  Takeharu Shiroki,Nobuhiro Tanuma,Ikuro Sato,Nobuyuki Tanaka,Kazuo Sugamura,Kennichi Satoh
- Organizer
  第72回日本癌学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24501326
[Presentation] Generation of knock-in mice to dissect isoform-specific roles for each splicing isoform of pyruvate kinase M in vivo2013
- Author(s)
  松本祥子、坂本良美、野村美有樹、田中遼大、盛田麻美、伊藤しげみ、椎葉健一、野村栄樹、片倉隆一、山下洋二、佐藤郁郎、渡邊利雄、島礼、田沼延公
- Organizer
  第36回分子生物学会
- Place of Presentation
  神戸
- Year and Date
  2013-12-05
- Data Source
  KAKENHI-PROJECT-24659621
[Presentation] ピルビン酸キナーゼMと、がんの代謝2013
- Author(s)
  田沼延公
- Organizer
  第1回がんと代謝研究会
- Place of Presentation
  鶴岡
- Year and Date
  2013-10-30
- Data Source
  KAKENHI-PROJECT-24659621
[Presentation] Functions of pyruvate kinase M(PKM)isoforms in tumor development2013
- Author(s)
  Tanuma N
- Organizer
  第72回日本癌学会学術集会Symposia"Cancer Cell Metabolism"
- Place of Presentation
  横浜
- Year and Date
  2013-10-05
- Data Source
  KAKENHI-PROJECT-24659621
[Presentation] The pyruvate kinase type M2 (PKM2) expression is enhanced and induces cellular proliferation in human pancreatic cancer cells2013
- Author(s)
  横山美沙、渋谷利恵、白木健悠、田沼延公、玉井恵一、山口壹範、田中伸幸、菅村和夫、佐藤賢一
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸
- Year and Date
  2013-12-05
- Data Source
  KAKENHI-PROJECT-24659621
[Presentation] Generation of knock-in mice to dissect isoform-specific roles for each splicing isoform of pyruvate kinase M in vivo2013
- Author(s)
  松本祥子、坂本良美、野村美有樹、田中遼大、盛田麻美、伊藤しげみ、椎葉健一、野村栄樹、片倉隆一、山下洋二、佐藤郁郎、渡邊利雄、島礼、田沼延公
- Organizer
  第36回分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25430163
[Presentation] PKMスイッチ不可能なマウスモデルの開発2013
- Author(s)
  田沼延公
- Organizer
  日本癌学会がん代謝シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24659621
[Presentation] Roles for pyruvate kinase M (PKM) isoforms in tumor metabolism2013
- Author(s)
  Tanuma N
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸
- Year and Date
  2013-12-05
- Data Source
  KAKENHI-PROJECT-24659621
[Presentation] がんの代謝とピルビン酸キナーゼM-ノックインモデルを用いた解析2013
- Author(s)
  田沼延公
- Organizer
  第15回がん・エピゲノム研究会
- Place of Presentation
  仙台
- Year and Date
  2013-04-03
- Data Source
  KAKENHI-PROJECT-24659621
[Presentation] Pyruvate kinase type M2(PKM2)is involved in human gastric cancer development.2013
- Author(s)
  Takeharu Shiroki,Nobuhiro Tanuma,Ikuro Sato,Nobuyuki Tanaka,Kazuo Sugamura,Kennichi Satoh
- Organizer
  第72回日本癌学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25430163
[Presentation] ピルビン酸キナーゼMと、がんの代謝2013
- Author(s)
  田沼延公
- Organizer
  第１回　がんと代謝研究会
- Place of Presentation
  鶴岡
- Invited
- Data Source
  KAKENHI-PROJECT-24501326
[Presentation] Generation of knock-in mice to dissect isoform-specific roles for each splicing isoform of pyruvate kinase M in vivo2013
- Author(s)
  松本祥子、坂本良美、野村美有樹、田中遼大、盛田麻美、伊藤しげみ、椎葉健一、野村栄樹、片倉隆一、山下洋二、佐藤郁郎、渡邊利雄、島礼、田沼延公
- Organizer
  第36回分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25640072
[Presentation] ノックインモデルを用いた、ピルビン酸キナーゼM(PKM)アイソフォームの機能解析2013
- Author(s)
  坂本良美、渡邊利雄、野村美有樹、山下洋二、椎葉健一、佐藤郁郎、佐藤雅美、島礼、田沼延公
- Organizer
  第72回日本癌学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2013-10-05
- Data Source
  KAKENHI-PROJECT-24659621
[Presentation] ノックインモデルを用いた、ピルビン酸キナーゼM（PKM）アイソフォームの機能解析2013
- Author(s)
  坂本良美、渡邊利雄、野村美有樹、山下洋二、椎葉健一、佐藤郁郎、佐藤雅美、島礼、田沼延公
- Organizer
  第72回日本癌学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24659621
[Presentation] ピルビン酸キナーゼM（PKM）の発現アイソフォームを固定したマウス・細胞モデル2013
- Author(s)
  田沼延公、ほか10名
- Organizer
  第８５回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23659700
[Presentation] ノックインモデルを用いた、ピルビン酸キナーゼM（PKM）アイソフォームの機能解析2013
- Author(s)
  坂本良美、渡邊利雄、野村美有樹、山下洋二、椎葉健一、佐藤郁郎、佐藤雅美、島礼、田沼延公
- Organizer
  第72回日本癌学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24501326
[Presentation] A mouse model incapable of switching PKM isoforms2012
- Author(s)
  田沼延公、渡邊利雄、野村美有樹、佐藤郁郎、椎葉健一、山下洋二、佐藤雅美、島礼
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Year and Date
  2012-09-20
- Data Source
  KAKENHI-PROJECT-23659700
[Presentation] A mouse model incapable of switching PKM isoforms2012
- Author(s)
  田沼延公、渡邊利雄、野村美有樹、佐藤郁郎、椎葉健一、山下洋二、佐藤雅美、島礼
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Year and Date
  2012-09-20
- Data Source
  KAKENHI-PROJECT-23650629
[Presentation] A mouse model incapable of switching PKM isoforms2012
- Author(s)
  田沼延公、渡邊利雄、野村美有樹、佐藤郁郎、椎葉健一、山下洋二、佐藤雅美、島礼
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Year and Date
  2012-09-20
- Data Source
  KAKENHI-PROJECT-22390272
[Presentation] A mouse model incapable of switching PKM isoforms2012
- Author(s)
  Tanuma N、ほか３名
- Organizer
  第７１回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24659621
[Presentation] 悪性グリオーマ検体およびグリオーマ樹立株におけるPTPzetaの解析2012
- Author(s)
  山下洋二、春日井勲、田沼延公、柴原一陽、園田順彦、金森政之、齋藤竜太、隈部俊宏、冨永悌二、島礼、片倉隆一
- Organizer
  日本脳神経外科学会第71回総会
- Place of Presentation
  大阪
- Year and Date
  2012-10-18
- Data Source
  KAKENHI-PROJECT-23659700
[Presentation] ピルビン酸キナーゼM（PKM）の発現アイソフォームを固定したマウス・細胞モデル2012
- Author(s)
  田沼延公、ほか10名
- Organizer
  第８５回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23650629
[Presentation] A mouse model incapable of switching PKM isoforms2012
- Author(s)
  Tanuma N、ほか３名
- Organizer
  第７１回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23659700
[Presentation] A mouse model incapable of switching PKM isoforms2012
- Author(s)
  Tanuma N、ほか３名
- Organizer
  第７１回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23650629
[Presentation] A mouse model incapable of switching PKM isoforms2012
- Author(s)
  Tanuma N、ほか３名
- Organizer
  第７１回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24501326
[Presentation] ピルビン酸キナーゼM（PKM）の発現アイソフォームを固定したマウス・細胞モデル2012
- Author(s)
  田沼延公、ほか10名
- Organizer
  第８５回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24501326
[Presentation] リン酸化によるスプライシング装置タンパクSap155/Sf3b1制御機構2012
- Author(s)
  田沼延公
- Organizer
  日本プロテインホスファターゼ研究会学術集会
- Place of Presentation
  大阪
- Year and Date
  2012-01-19
- Data Source
  KAKENHI-PROJECT-22659248
[Presentation] リン酸化によるスプライシング装置タンパクSap155/Sf3b1制御機構2012
- Author(s)
  田沼延公
- Organizer
  日本プロテインホスファターゼ研究会学術集会
- Place of Presentation
  大阪
- Year and Date
  2012-01-19
- Data Source
  KAKENHI-PROJECT-22700893
[Presentation] リン酸化によるスプライシング装置タンパク Sap155/Sf3b1 制御機構2012
- Author(s)
  田沼延公
- Organizer
  日本プロテインホスファターゼ研究会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23659700
[Presentation] Development of mouse brain tumor models derived from neural stem cells-神経幹細胞を用いたマウス脳腫瘍モデルの構築2011
- Author(s)
  大西伸幸、田沼延公
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22659248
[Presentation] Switch of pyruvate kinase M (PKM) isoforms in human breast cancers2011
- Author(s)
  田沼延公
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23650629
[Presentation] 「グリオーマにおけるピルビン酸キナーゼM（PKM)スプライシングのスイッチ機構」2011
- Author(s)
  田沼延公,片倉隆一
- Organizer
  第29回日本脳腫瘍学会学術集会
- Place of Presentation
  下呂温泉　水明館
- Data Source
  KAKENHI-PROJECT-23659700
[Presentation] Embryonic Lethality Caused in Mice Lacking the phosphatase domain of the PP6c gene2011
- Author(s)
  Ayako Kishimoto, Nobuhiro Tanuma
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-22659248
[Presentation] Development of mouse brain tumor models derived from neural stem cells-神経幹細胞を用いたマウス脳腫瘍モデルの構築2011
- Author(s)
  田沼　延公
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23650629
[Presentation] ピルビン酸キナーゼPKM2とダイオキシン受容体AhRの相互作用の機能解明2011
- Author(s)
  田沼　延公
- Organizer
  日本環境変異原学会第40回大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23650629
[Presentation] Phospho-Regulation of Spliceosomal Protein, Sap155/Sf3b12011
- Author(s)
  田沼延公
- Organizer
  9^<th> International Conference on Protein Phosphatrase
- Place of Presentation
  東京
- Year and Date
  2011-02-01
- Data Source
  KAKENHI-PROJECT-22700893
[Presentation] Embryonic Lethality Caused in Mice Lacking the phosphatase domain of the PP6c gene2011
- Author(s)
  Nobuhiro Tanuma
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23659700
[Presentation] グオーマにおけるピルビン酸キナーゼM(PKM)スプライシングのスイッチ機構2011
- Author(s)
  山下洋二、田沼延公
- Organizer
  日本脳神経外科学会第70回学術総会
- Place of Presentation
  横浜
- Year and Date
  2011-10-13
- Data Source
  KAKENHI-PROJECT-22659248
[Presentation] Generation of isoform-specific antibodies against pyruvate kinase(PKM)2010
- Author(s)
  野村美有樹、田沼延公、椎葉健一
- Organizer
  第69回日本癌学会総会
- Place of Presentation
  横浜
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22659248
[Presentation] Drift of pyruvate kinase M (PKM) alternative splicing associating with Warburg effect in human cancers.2010
- Author(s)
  田沼延公
- Organizer
  BMB2010 第33回日本分子生物学会年会第83回日本生化学学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22700893
[Presentation] Conversion of pyruvate kinase M(PKM) isozymes in human cancers-an analysis using isoform-specific antibodies2010
- Author(s)
  野村美有樹、田沼延公
- Organizer
  BMB2010第33回日本分子生物学会年会第83回日本生化学学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-22659248
[Presentation] Aberrant pre-mRNA splicing of pyrubate kinase M(PKM) in human cancer2010
- Author(s)
  田沼延公、椎葉健一
- Organizer
  第69回日本癌学会総会
- Place of Presentation
  横浜
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-22659248
[Presentation] 神経膠腫で発現が認められるプロテインホスファターゼ、DUSP26はKIF3モーターを制御し細胞間接着に働く2009
- Author(s)
  田沼延公
- Organizer
  第10回日本分子脳神経外科学会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20591730
[Presentation] Down regulation of DUSP26 may contribute to malignant phenotype of glioma.2009
- Author(s)
  田沼延公
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20591730
[Presentation] 脳腫瘍におけるDUSP26発現低下とその意義2009
- Author(s)
  田沼延公
- Organizer
  第4回日本プロテインホスファターゼ研究学術集会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-20591730
[Presentation] Dusp26 Associates with KIF3 Motor and Promotes Cadherin-Mediated Cell-Cell Adhesion EUROPHOSPHATASE 20092009
- Author(s)
  Miyuki Nomura, Nobuhiro Tanuma, Isao Kasugai, Masami Sato, Hiroshi Shima
- Organizer
  Protein phosphatases in development and disease, Egmond aan Zee
- Place of Presentation
  The Netherlands
- Year and Date
  2009-07-16
- Data Source
  KAKENHI-PROJECT-19390370
[Presentation] NIPP1 Directs PP1 to Dephosphorylate the Essential Pre-mRNA Splicing Factor, Sap 1552008
- Author(s)
  Nobuhiro Tanuma, Kunimi Kikuchi, Hiroshi Shima
- Organizer
  8th International Conference on Cellular Regulation by Protein Phosphatases "Protein Phosphatases: From Genome to Disease"
- Place of Presentation
  Maebashi, Japan
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] ホスファターゼPP1-NIPP1ホロ酵素によるU2snRNPのSap155/Sf3b1サブユニットの脱リン酸化 Phosphatase PP1-NIPP1 holoenzyme de-phosphorylates Sap155/Sf3b1 of U2snRNP2008
- Author(s)
  田沼延公、野村美有樹、島礼
- Organizer
  第67回日本癌学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] プロテインホスファターゼPP1/NIPP1複合体によるSap155/Sf3b1の脱リン酸化とsplicing制御機構2008
- Author(s)
  田沼延公、椿耶緒、野村美有樹、菊池九二三、島礼
- Organizer
  BMB2008第31回日本分子生物学会第81回日本生化学会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] DUSP26によるキネシンモーターKIF3の制御およびCadherin 依存性細胞接着の亢進2008
- Author(s)
  野村美有樹、田沼延公、池田正稔、春日井勲、菊池九二三、島礼
- Organizer
  BMB2008第31回日本分子生物学会第81回日本生化学会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] PP1/NIPP1複合体によるU2snRNPのSap155/Sf3b1構成タンパク、Sap155/Sf3b1の脱リン酸化2008
- Author(s)
  田沼延公、椿耶緒、野村美有樹、菊池九二三、島礼
- Organizer
  BMB2008第31回日本分子生物学会第81回日本生化学会合同大会シンポジウム「3S22ホスファターゼスーパーファミリーの機能と異常:ゲノムから疾患まで」
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] DUSP26はKIF3Aと結合しKAP3の脱リン酸化を促進する2008
- Author(s)
  野村美有樹、田沼延公、高垣謙太郎、島礼
- Organizer
  第67回日本癌学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] 二重基質特異性ホスファターゼLDP-4とキネシンの結合2007
- Author(s)
  野村美有樹,田沼延公,高垣謙太郎,菊池九二三,島礼
- Organizer
  BMB2007第30回日本分子生物学会第80回日本生化学会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] NIPP1-PP1cホロ酵素によるU2snRNPコンポーネントSap155/SF3b1の脱リン酸化2007
- Author(s)
  田沼延公,金世殷,椿耶緒,島礼,三橋進也,野村美有樹,菊池九二三
- Organizer
  BMB2007第30回日本分子生物学会第80回日本生化学会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] Low-molecular-mass dual specificity phosphatase-4(LDP-4) functions as an activator of JNK and p38.2007
- Author(s)
  野村美有樹、高垣謙太郎、田沼延公、菊池九二三、島礼
- Organizer
  第66回日本癌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] LDP-4, a cancer-associated dual-specificity protein phosphatase binds kinesine2007
- Author(s)
  田沼延公、高垣謙太郎、野村美有樹、菊池九二三、島礼
- Organizer
  第66回日本癌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] PP1 de-regulation by a mutant form of NIPP1 lacking the C-terminal region2007
- Author(s)
  Nobuhiro Tanuma, Shinya Mitsuhashi, Miyuki Nomura, Yao Tsubaki, Sei-Eun Kim, Kunimi Kikuchi, Hiroshi Shima
- Organizer
  EUROPHOSPHATASES 2007, Protein Phosphatases in Health and Disease
- Place of Presentation
  Aveiro, Portugal
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] Characterization of LDP-4, a cancer-associated dual-specificity phosphatase2007
- Author(s)
  Miyuki Nomura, Kentaro Takagaki, Nobuhiro Tanuma, Kumimi Kikuchi, Hiroshi Shima
- Organizer
  EUROPHOSPHATASES 2007, Protein Phosphatases in Health and Disease
- Place of Presentation
  Aveiro, Portugal
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] Function of MKP-7, at chromosome 12p, towards MAPK cascade2007
- Author(s)
  Hiroshi Shima, Chiaki Katagiri, Kouhei Masuda, Miyuki Nomura, Isao Kasugai, Nobuhiro Tanuma
- Organizer
  Mechanisms and Models of Cancer Meeting
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] ピルビン酸キナーゼM2(PKM2)は膵癌で高発現し、細胞増殖能を亢進させる
- Author(s)
  横山美沙、白木健悠、田沼延公、玉井恵一、山口壹範、田中伸幸、菅村和夫、佐藤賢一
- Organizer
  第７３回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26462077
[Presentation] ピルビン酸キナーゼM（PKM）の発現アイソフォームを固定したマウス・細胞モデル
- Author(s)
  田沼延公、ほか10名
- Organizer
  第８５回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22390272
[Presentation] A mouse model incapable of switching PKM isoforms
- Author(s)
  Tanuma N、ほか３名
- Organizer
  第７１回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22390272

1. SHIMA Hiroshi (10196462)

# of Collaborated Projects: 13 results

# of Collaborated Products: 45 results
2. KIKUCHI Kunimi (20006117)

# of Collaborated Projects: 9 results

# of Collaborated Products: 6 results
3. ITO Shigemi (80600006)

# of Collaborated Projects: 9 results

# of Collaborated Products: 11 results
4. SATO Ikuro (50225918)

# of Collaborated Projects: 8 results

# of Collaborated Products: 19 results
5. NOMURA Miyuki (40390893)

# of Collaborated Projects: 6 results

# of Collaborated Products: 23 results
6. YAMASHITA Yoji (30420045)

# of Collaborated Projects: 4 results

# of Collaborated Products: 7 results
7. SHIIBA Kenichi (90196345)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
8. SATO Masami (30250830)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
9. Yamada Hidekazu (10254012)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
10. 盛田麻美 (20647193)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
11. 佐藤卓 (90814541)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
12. KATAKURA Ryuuichi (10442675)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
13. SASAKI Nozomi (50467429)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. YOKOYAMA Masayuki (20220577)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. SONODA Yukihiko (90302140)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. NAKAMURA Yoshihiro (60381159)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. SAKASEGAWA Koichi (80601393)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. OTSUKA Tsunayuki (40464466)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. NAGATA Toshiyuki (70611763)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. AOKI Masaya (50624996)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. SATO Masayuki (00573685)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. Yamamoto Kuniharu (00375073)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. NAKAMURA Kouji (70281839)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 佐藤賢一 (10282055)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
25. 安田純 (00281684)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 長南雅志 (90813676)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 海野雄加 (30433212)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. KAWAI Masaaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
29. 本橋ほづみ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 西田基宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 藤井重元

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 赤池孝章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 渡辺利雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
34. 前門戸任

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TANUMA Nobuhiro 田沼 延公

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がん代謝と自然免疫シグナル伝達経路のミッシングリンクPrincipal Investigator

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がんの代謝脆弱性をターゲットする新規治療とメカニズムPrincipal Investigator

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Escape from energy/NAD-interdependence in malignant cancersPrincipal Investigator

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The yin and yang of the Warburg effect of tumors.Principal Investigator

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Molecular mechanisms by which PKM1, reversing the Warburg effect, promotes tumor cell growth.Principal Investigator

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Active glucose metabolism and tumor promotion mediated by Pkm1Principal Investigator

TANUMA Nobuhiro 田沼延公