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Inoue Tohru  井上 達

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INOUE Tohru  井上 達

井上 逹  イノウエ トオル

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Researcher Number 50100110
Other IDs
External Links
Affiliation (Current) 2025: 国立医薬品食品衛生研究所, 安全性生物試験研究センター, 客員研究員
Affiliation (based on the past Project Information) *help 2010 – 2011: 国立医薬品食品衛生研究所, 安全性生物試験研究センター, 客員研究員
2001 – 2009: Center for Biological Safcty & Research, National Institute of Health Sciences, Director, 安全性生物試験研究センター, センター長
2006: 国立医薬品食品衛生研究所, 安全欧生物試験研究センター, センター長
1997 – 2000: 国立医薬品食品衛生研究所, 毒性部, 部長
1997 – 1998: 国立医薬品食品衛生研究所, 安全性生物試験研究センター・毒性部, 部長 … More
1997: 国立衛生試験所, 毒性部, 部長(研究職)
1997: National Institute of Health Science, Toxicology, Chairman, 毒性部, (研究職)部長
1997: 安全性生物試験研究センター, 毒性部, 部長
1996 – 1997: 国立衛生試験所, 毒性部, 部長
1996: 厚生省国立衛生試験所, 安全生物試験研究センター, 部長
1996: 国立衛生試験所, 安全性生物試験研究センター・毒性部, 部長
1994: 横浜市立大, 医学部, 助教授
1986 – 1994: 横浜市立大学, 医学部, 助教授
1991: 横浜市立大学, 医学部・病理学教室, 助教授
1991: Yokohama City Univ. School of Med. Assoc. Professer, 医学部・病理学第一講座, 助教授
1990: 横浜市立大学, 医学部病理学第一講座, 助教授
1988: Dept. of Pathol. Yokohama City University School of Medicine, 医学部病理学教室, 助教授
1987: 横浜市立大学, 病理学教室・医学部, 助教授 Less
Review Section/Research Field
Principal Investigator
Experimental pathology / Risk sciences of radiation/Chemicals / 広領域 / 老化(加齢)
Except Principal Investigator
Pediatrics / Experimental pathology / Experimental pathology / 広領域 / General medical chemistry
Keywords
Principal Investigator
造血幹細胞 / 遺伝子改変動物 / サイトカイン / 細胞周期 / サイトカイン受容体 / 遺伝子導入 / CFU-S / hemopoietic stem cell / アリールハイドロカーボン受容体 / apoptosis … More / gap junction / アポトーシス / ギャップ結合細胞間連絡 / ペンタクロロフェノール / p53 / Hemopoietic stem cells / 放射線感受性 / CFUーS / ベンゼン代謝物 / ベンゼン / Ah受容体ノックアウトマウス / CYP2E1 / Ah受容体 / サブユニット構造 / 分裂寿命 / 多能性造血幹細胞 / がん遺伝子 / transgenic mouse / spleen colony forming cells / リンパ球系前駆細胞 / 胸腺組織支持細胞 / 放射線抵抗性亜分画 / 細胞加齢 / トランスジェニックマウス / 脾コロニー / benzene metabolites / benzene / suppression of the hemopoiesis / AhR knockout mouse / BUUV method / cell cycle / Arylhydrocarbon receptor (AhR) / Cyp2E1 / 骨髄造血抑制 / BUUV法 / アリールハイドロカーボン(Ah)受容体 / pentachlorophenol / connexin / promotion / Gap junction(細胞間連絡) / コネクシン / 発がんプロモーター / Dioxin / Hemopoietic cell / Ary Ihydrocarbon receptor / ダイオキシン / pentachlorohenol / ギャップ結合細胞間コミュニケーション / gene mutation / developmental toxicity / Embryonic stem cell / 突然変異検出系 / 分化 / 遺伝子突然変異 / 発生傷害 / 胚幹細胞 / hematopoietic progenitor cells / TGF-β / sytokine / p53-deficient mice / 骨髄造血前駆細胞 / TGFβ / P53欠失マウス / Radiation sensitivity / spleen colonies. / CFU-S (colony forming Unit S) / 脾コロニ- / 遺伝子発現変化 / 遺伝子改変マウス / 遺伝子発現変 / 芳香族炭化水素受容体(AhR) / 酸化的ストレス / 生体異物相互作用 / 幹細胞ニッチ / 幹細胞老化 / 移植アッセイ / 移植効率 / p53欠失マウス / 受容体サブユニット / IL-3受容体 / 脾コロニー法 / サイトカイン・レセプター遺伝子 / 脾コロニ-法 / サイトカイン・レセプタ-遺伝子 / 夛能性造血幹細胞 … More
Except Principal Investigator
造血幹細胞 / レセプター / サイトカイン / hematopoietic stem cell / p53 / JAK2 / STAT / NF-AT / TGF / thrombopoietin / stem cell / cell line / megakaryocyte / GM-CSF / シグナル伝達 / トランスジェニックマウス / 細胞周期 / myc遺伝子 / IL-3 / LIF / 遺伝子導入 / ミエロペルオキシダーゼ / benzene / suppression of hematopoiesis / BUUV method / Thioredoxin knockout mice / cell cycle / Thioredoxin overexpression mice / Thioredoxin / ベンゼン / 骨髄造血抑制 / BUUV法 / チオレドキシンノックアウトマウス / チオレドキシン過剰発現マウス / チオレドキシン / Gompertzean expression / p53-konckout mice / klotho mutated mice / Hemopoietic stem cell / multiplication theory for senescence / ゴンペルツ生存曲線 / p53欠失マウス / klotho遺伝子変異マウス / 加齢の多因子乗算論 / apoptosis / TGF-beta / Hematopoletic progenitor / アポトーシス / TGF-β / Immune response / Transcription factor / 免疫応答 / T細胞サブセット / GM-CSF受容体 / JAK / 免疫反応 / 転写因子 / cytokine / 無蛋白培養 / 細胞株 / 巨核球 / proliferation / differentiation / hematopoietic cell / transgenic mice / signal transduction / receptor expression / Cytokine receptor / GM-CSF receptor / EBNA / E2 / E1 / 複製 / EBV / BPV / ポリオーマ / エピソームベクター / ステムセル / 幹細胞 / エピゾーム / コロニー形成法 / 造血細胞 / 増殖 / 分化 / 血球細胞 / レセプター発現 / サイトカインレセプター / GM-CSFレセプター / Erythropoietin / Leukemia Inhibitory Factor / Stem Cell Factor / Interleukin 6 / Interleukin / Hemopoietic Stem Cells / CD_<34> / 免疫磁気ビ-ズ / 老化 / 幹細胞増殖因子 / 白血病阻害因子 / インタ-ロイキン6 / インタ-ロイキン3 / エリスロポイエチン / SCF / ILー6 / ILー3 / 血液幹細胞 / フレンド白血病 / WW^vマウス / PCR / 白血病株細胞 / 造血因子遺伝子 / 肺発癌プロモーター / 気道上皮細胞動態 / クララ細胞の代謝活性 / 細胞分離 / クララ細胞(細気管支無線毛上皮細胞) / グリセロール / クマリンハイドロキシラーゼ / 4NQO肺内代謝 / 肺発癌促進 / クララ細胞 / 酸化的ストレス / 生体異物相互作用 / 幹細胞ニッチ / 細胞死 / 増殖機構 / Id / 6M-CSF / ES(胚幹)細胞 / 貧血マウス / 松果体 / がん遺伝子 / フレンドウイルス / クローン性増殖 / 白血病 Less
  • Research Projects

    (29 results)
  • Research Products

    (172 results)
  • Co-Researchers

    (41 People)
  •  Toxicity mechanism in hematopoietic stem/progenitor-derived signaling via aryl hydrocarbon receptors induced by benzene exposurePrincipal Investigator

    • Principal Investigator
      INOUE Tohru
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      National Institute of Health Sciences
  •  Mechanism underlying functional impairment of hematopoietic stem cell niches caused by oxidative stress at the site of xenobiotic interrelationship

    • Principal Investigator
      HIRABAYASHI Yoko
    • Project Period (FY)
      2008 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      National Institute of Health Sciences
  •  Biological function of aryl hydrocarbon receptors in the hematopoietic progenitor cells with respect to a possible toxicologic mechanismPrincipal Investigator

    • Principal Investigator
      INOUE Tohru
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      National Institute of Health Sciences
  •  Oxidative stress-related xenobiotic responsive molecule : Study using mice with modified thioredoxin gene expression.

    • Principal Investigator
      HIRABAYASH Yoko
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      National Institute of Health Sciences
  •  Mechanism of benzene-induced hematopoietic disturbances mediated by arylhydrocarbon receptorsPrincipal Investigator

    • Principal Investigator
      INOUE Tohru
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      National Institute of Health Sciences
  •  Establishment of biotechnology-derived recombinant mice expressing accelerated aging -a sensitive model for drug-induced epigenetic damages

    • Principal Investigator
      HIRABAYASHI Yoko
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      National Institute of Health Sciences
  •  Study on the signal cross talk bencath the Arythydroearbon receptor in the hemopoietic stem cells.Principal Investigator

    • Principal Investigator
      INOUE Tohru
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      National Institute of Health Sciences
  •  Blocks of cell communication and apoptosis in carcinogenesisPrincipal Investigator

    • Principal Investigator
      INOUE Tohru
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Experimental pathology
    • Research Institution
      National Institute of Health Sciences
  •  薬剤評価モデルとしてのヒト型造血因子受容体遺伝子導入マウスとその造血幹細胞動態制御Principal Investigator

    • Principal Investigator
      井上 達
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      国立衛生試験所
  •  p53 null mice and chemical oncogenesis for promotion studyPrincipal Investigator

    • Principal Investigator
      INOUE Tohru
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Experimental pathology
    • Research Institution
      National Institute of Health Sciences
  •  遺伝子改変動物の造血幹細胞動態制御を指標としたサイトカイン系薬剤評価モデルの開発Principal Investigator

    • Principal Investigator
      井上 達
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      国立衛生試験所
  •  Signal transduction mediated by hematopoietic factors and TGF-β in p53-deficient micePrincipal Investigator

    • Principal Investigator
      INOUE Tohru
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      National Institute of Health Sciences
  •  Construction of mouse embryonic stem cells for the detection of gene mutationPrincipal Investigator

    • Principal Investigator
      INOUE Tohru
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      広領域
    • Research Institution
      National Institute of Health Sciences
  •  Characterization of hematopoietic stem cells in p53-deficient mice

    • Principal Investigator
      SASAKI Hideki
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      YOKOHAMA CITY UNIVERSITY
  •  Generation of disease model mice by the alteration of transcription factors regulating immune responses

    • Principal Investigator
      ARAI Ken-ichi
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Experimental pathology
    • Research Institution
      The University of Tokyo
  •  myc遺伝子導入造血幹細胞における増殖と細胞死シグナルの解析

    • Principal Investigator
      佐々木 秀樹
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Yokohama City University
  •  造血幹細胞へのサイトカイン受容体遺伝子導入による造血調節因子作用機構に関する研究Principal Investigator

    • Principal Investigator
      井上 達
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Yokohama City University
  •  P53欠失マウスを用いた連続骨髄移植法による造血幹細胞不死化に関する研究Principal Investigator

    • Principal Investigator
      井上 達
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      老化(加齢)
    • Research Institution
      Yokohama City University
  •  遺伝子導入ES細胞を用いたマウス胚初期発生におけるサイトカインの役割の研究

    • Principal Investigator
      ARAI Ken-ichi
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      The University of Tokyo
  •  Studies on regulatory mechanisms of megakaryocytepoiesis using the cell line grown in protein-free culture.

    • Principal Investigator
      SASAKI Hideki
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Yokohama City University School of Medicine
  •  多能性造血幹細胞への遺伝子導入とその機能発現Principal Investigator

    • Principal Investigator
      井上 達
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Yokohama City University
  •  Development of high-level expression vectors in embryonic and hematopoietic stem cells and generati of GM-CSF and IL-3 of receptor transgenic mice

    • Principal Investigator
      ARAI Ken-ichi
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      広領域
    • Research Institution
      The University of Tokyo
  •  多能性造血幹細胞への遺伝子導入と、その機能発現Principal Investigator

    • Principal Investigator
      井上 達
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Yokohama City University
  •  Study on a fraction with relative radioresistency from murine pluripotent hemopoietic stem cells.Principal Investigator

    • Principal Investigator
      INOUE Tohru
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Yokohama City University, Sohool of Medicine
  •  造血幹細胞の不死化・白血病化によるクローン性増殖発展の制御機構

    • Principal Investigator
      三浦 恭定
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Jichi Medical University
  •  The mechanisms of proliferation and differentiation of hematopoietic multipotent stem cells.

    • Principal Investigator
      SASAKI Hideki
    • Project Period (FY)
      1989 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Yokohama City University, School of Medicine
  •  造血幹細胞の不死化・白血病化によるクローン性増殖発展の制御機構

    • Principal Investigator
      三浦 恭定
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Jichi Medical University
  •  Study on proliferation and Differentiation of pluripotent hemopoietic stem cells (CFU-S).Principal Investigator

    • Principal Investigator
      INOUE Tohru M.D.
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Department of Pathology, Yokohama City University School of Medicine
  •  細気管支無線毛(Clara)細胞の代謝活性と細胞動態

    • Principal Investigator
      蟹沢 成好
    • Project Period (FY)
      1985 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Yokohama City University

All 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Other

All Journal Article Presentation Book Patent

  • [Book] Handbook of Systems Toxicology, Vol.1(Casciano DA, Sahu SC, eds)(Commonality and Stochasticity in Systems Toxicology.)2011

    • Author(s)
      Hirabayashi Y, Inoue T.
    • Publisher
      Hoboken, NJ John Wiley & Sons, Ltd.
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Book] Commonality and Stochasticity in Systems Toxicology In Handbook of Systems Toxicology (D.A.Casciano, and S.C.Sahu, Eds.)2011

    • Author(s)
      Hirabayashi Y, Inoue I
    • Publisher
      John Wiley & Sons, Ltd., Hoboken.NJ
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Book] Commonality and Stochasticity in Systems Toxicology In Handbook of Systems Toxicology(D.A.Casciano, and S.C.Sahu, Eds.)2011

    • Author(s)
      Hirabayashi Y, Inoue T
    • Publisher
      John Wiley & Sons, Ltd., Hoboken, NJ
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Book] Commonality and Stochasticity in Systems Toxicology In Handbook of Systems Toxicology (D.A.Casciano, and S.C.Sahu,Eds.)2011

    • Author(s)
      Hirabayashi Y, Inoue T
    • Publisher
      John Wiley & Sons,Ltd., Hoboken, NJ
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Book] Commonality and Stochasticity in Systems Toxicology In Handbook of Systems Toxicology(D.A.Casciano, and S.C.Sahu, Eds.)2011

    • Author(s)
      Hirabayashi Y, Inoue T
    • Publisher
      John Wiley & Sons, Ltd., Hoboken, NJ
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Book] Commonality and Stochasticity in Systems Toxicology. In : Handbook of Systems Toxicology2011

    • Author(s)
      Hirabayashi Y, Inoue T.
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Book] Commonality and Stochasticity in Systems Toxicology. In : Handbook of Systems Toxicology2011

    • Author(s)
      Hirabayashi Y, Inoue T
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Book] Aryl hydrocarbon receptor suppresses spontaneous neoplasms thereby extends life span. In : Morita M, edPersistent Organic Pollutants(POPs) Research in Asia2008

    • Author(s)
      Hirabayashi Y, Yoon BI, Li GX, Kaneko T, Kanno J, Fujii-Kuriyama Y, Inoue T
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Book] Principles of data-mining in toxicogenomics. In : Toxico-genomics : A Powerful Tool for Toxicity Assessment2008

    • Author(s)
      Hirabayashi Y, Inoue T
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Book] Toxicogenomics : A Powerful Tool for Toxicity Assessment (Sahu SC, ed)(Principles of data-mining in toxicogenomics.)2008

    • Author(s)
      Hirabayashi Y, Inoue T.
    • Publisher
      Hoboken, NJ John Wiley & Sons, Ltd.
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Book] 新しい視点からみたトキシコロジー-発生・成長・老化-In : トキシコロジーの到達点と新しい展望-多様性科学としてのトキシコロジー-2007

    • Author(s)
      井上 達
    • Total Pages
      145
    • Publisher
      第33回日本トキシコロジー学会学術年会(監修 堀井郁夫)
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Book] Principles of data-mining in toxicogenomics. In Toxicogenomics: A Powerful Tool for Toxicity Assessment (S. C. Sahu, Ed.)2007

    • Author(s)
      Hirabayashi Y、Inoue T.
    • Publisher
      John Wiley & Sons, Ltd.
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Book] Chapter 24. Toxicogenomics Applied to Hematotoxicology. In : J Borlak (ed) Handbook of Toxicogenomics.2005

    • Author(s)
      Hirabayashi Y, Inoue T
    • Publisher
      Weinheim : Wiley-VCH, Verlag GmbH
    • Data Source
      KAKENHI-PROJECT-16590329
  • [Book] Chapter 24. Toxicogenomics Applied to Hematotoxicology.(Handbook of Toxicogenomics) (In : J Borlak (ed))2005

    • Author(s)
      Hirabayashi Y, Inoue T
    • Publisher
      Weinheim : Wiley-VCH, Verlag GmbH
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590329
  • [Book] Chapter 24. Toxicogenomics Applied to Hematotoxicology. In : J Borlak (ed) Handbook of Toxicogenomics.2005

    • Author(s)
      Hirabayashi Y, Inoue T
    • Publisher
      Weinheim : Wiley-VCH, Verlag GmbH
    • Data Source
      KAKENHI-PROJECT-15510064
  • [Book] Toxicogenomics Applied to Hematotoxicology Handbook of Toxicogenomics (Eds: Borlak J., Weinheim)2005

    • Author(s)
      Hirabayashi Y, Inoue T
    • Publisher
      Wiley-VCH, Verlag GmbH
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510064
  • [Book] On the Mechanistic Differences of Benzene-induced Leukemogenesis between Wild type and p53 Knockout Mice. Molecular Mechanisms for Radiation-induced Cellular Response and Cancer Development. (Eds: Tanaka K, Takabatake T, Fujikawa K, Matsumoto T, Sato F.)2003

    • Author(s)
      Hirabayashi Y, Yoon BI, Kawasaki Y, Li GX, Kanno J, Inoue T
    • Publisher
      Aomori, Institute for Environmental Sciences:
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510064
  • [Book] Toxicogenomics (Introduction : Toxicogenomics-A new paradigm of Toxicology)(pp3-11)(Eds : Inoue T, Pennie WD.)2003

    • Author(s)
      Inoue T
    • Total Pages
      228
    • Publisher
      Springer, Tokyo
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15510064
  • [Book] Connexin 32 (Cx32) Plays Double Functions, a Promotion and a Protection, for the Chemically Induced Leukemogenesis. Molecular Mechanisms for Radiation-induced Cellular Response and Cancer Development. (Eds: Tanaka K, Takabatake T, Fujikawa K, Matsumoto T, Sato F. )2003

    • Author(s)
      Hirabayashi Y, Yoon BI, Tsuboi I, Huo Y, Kodama Y, Otto T, Kanno J, Willeck K, Trosko JE, Inoue T
    • Publisher
      Aomori, Institute for Environmental Sciences
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510064
  • [Book] Introduction: Toxicogenomics-A new paradigm of Toxicology (Toxicogenomics) (Eds: Inoue T, Pennie WD.)2003

    • Author(s)
      Inoue T
    • Publisher
      Springer, Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510064
  • [Book] 新しい視点からみたトキシコロジー-発生・成長・老化-. In トキシコロジーの到達点と新しい展望-多様性科学としてのトキシコロジー-(堀井郁夫編),

    • Author(s)
      井上達
    • Publisher
      第33回日本トキシコロジー学会学術年会
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Journal Article] The low-dose issue and stochastic responses to endocrine disruptors2011

    • Author(s)
      Hirabayashi Y, Inoue T
    • Journal Title

      J Appl Toxicol

      Volume: 31 Issue: 1 Pages: 84-88

    • DOI

      10.1002/jat.1571

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590388, KAKENHI-PROJECT-21510074
  • [Journal Article] Benzene-induced bone-marrow toxicity : a hemato-poietic stem-cell-specific, aryl hydrocarbon receptor-mediated adverse effect2010

    • Author(s)
      Hirabayashi Y, Inoue T.
    • Journal Title

      Chem Biol Interact

      Volume: 184(1-2) Pages: 252-252

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Journal Article] Hematopoietic neoplastic diseases develop in C3H/He and C57BL/6 mice after benzene exposure : strain differences in bone marrow tissue responses observed using microarrays2010

    • Author(s)
      Inoue T, Hirabayashi Y
    • Journal Title

      Chem Biol Interact

      Volume: 184(1-2) Pages: 240-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Journal Article] Hematopoietic neoplastic diseases develop in C3H/He and C57BL/6 mice after benzene exposure : strain differences in bone marrow tissue responses observed using microarrays2010

    • Author(s)
      Inoue T, Hirabayashi Y
    • Journal Title

      Chem Biol Interact

      Volume: 184 Pages: 240-245

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Journal Article] Benzene-induced hone-marrow toxicity : a hematopoictic stem-cell-specific, aryl hydrocarbon receptor-mediated adverse effect2010

    • Author(s)
      Hirabayashi Y, Inoue T
    • Journal Title

      Chern Biol Interact

      Volume: 184 Pages: 252-258

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Journal Article] Regeneration capability of Lin^-/c-Kit^+/Sca-1^+ cells with or without radiation exposure for repopulation of peripheral blood in lethally irradiated mice monitored using Ly5.1 isotype on days 35, 90, and 270 after transplantation.2010

    • Author(s)
      Otsuka K, Hirabayashi Y, Tsuboi I, Inoue T.
    • Journal Title

      Exp Hematol 38(5)

      Pages: 417-425

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Journal Article] Regeneration capability of Lin-/c-Kit^+/Sca-1^+cells with or without radiation exposure for repopulation of peripheral blood in lethally irradiated mice monitored using Ly5.1 isotype on days 35, 90, and 270 after transplantation2010

    • Author(s)
      Otsuka K, Hirabayashi Y, Tsuboi I, Inoue T.
    • Journal Title

      Exp Hematol

      Volume: 38(5) Pages: 417-425

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Journal Article] Benzene-induced bone-marrow toxicity : a hemato-poietic stem-cell-specific, aryl hydrocarbon receptor-mediated adverse effect2010

    • Author(s)
      Hirabayashi Y, Inoue T
    • Journal Title

      Chem Biol Interact

      Volume: 184(1-2) Pages: 252-258

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Journal Article] Benzene-induced bone-marrow toxicity : a hematopoietic stem-cell-specific, aryl hydrocarbon receptor-mediated adverse effect2010

    • Author(s)
      Hirabayashi Y, Inoue T
    • Journal Title

      Chem Biol Interact

      Volume: 184 Pages: 252-258

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Journal Article] Benzeneinduced bone-marrow toxicity : a hematopoietic stem-cell-specific, aryl hydrocarbon receptor-mediated adverse effect.2010

    • Author(s)
      Hirabayashi Y, Inoue T.
    • Journal Title

      Chem Biol Interact 184(1-2)

      Pages: 252-258

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Journal Article] Hematopoietic neoplastic diseases develop in C3H/He and C57BL/6 mice after benzene exposure : strain differences in hone marrow tissue responses observed using microarrays2010

    • Author(s)
      Inoue T, Hirabayashi Y
    • Journal Title

      Chem Biol Interact

      Volume: 184 Pages: 240-245

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Journal Article] Comparison of murine gene expression profiles between spontaneous and radiation-induced myelogenous leukemias : stochastic and probabilistic expression variances in the former vs. radiation-specific expression commonalities in the latter2009

    • Author(s)
      Hirabayashi Y, Tsuboi I, Kitada K, Igarashi K, Kodama Y, Kanno J, Yoshida, K, Dainiak, N. Inoue T.
    • Journal Title

      Exp Hematol

      Volume: 37(2) Pages: 195-205

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Journal Article] Benzene-induced hematopoietic neoplasms including myeloid leukemia in Trp53-deficient C57BL/6 and C3H/He mice2009

    • Author(s)
      Kawasaki Y, Hirabayashi Y, Kaneko T, Kanno J, Kodama Y, Matsushima Y, Ogawa Y, Saitoh M, Sekita K, Uchida O, Umemura T, Yoon BI, Inoue T
    • Journal Title

      Toxicol Sci

      Volume: 110(2) Pages: 293-306

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Journal Article] Aryl hydrocarbon receptor biology and xenobiotic responses in hematopoietic progenitor cells.2009

    • Author(s)
      Hirabayashi Y、Inoue T.
    • Journal Title

      Biochem Pharmacol 77

      Pages: 521-35

    • Data Source
      KAKENHI-PROJECT-18510066
  • [Journal Article] Comparison of murine gene expression profiles between spontaneous and radiation-induced myelogenous leukemias : stochastic and probabilistic expression variances in the former vs.radiation-specific expression commonalities in the latter.2009

    • Author(s)
      Hirabayashi Y, Tsuboi I, Kitada K, Igarashi K, Kodama Y, Kanno J, Yoshida, K, Dainiak, N., Inoue T.
    • Journal Title

      Exp Hematol 37(2)

      Pages: 195-205

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Journal Article] Aryl hydrocarbon receptor biology and xenobiotic responses in hematopoietic progenitor cells.2009

    • Author(s)
      Hirabayashi Y, Inoue T.
    • Journal Title

      Biochem Pharmacol 77(4)

      Pages: 521-535

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Journal Article] Aryl hydrocarbon receptor biology and xenobiotic responses in hematopoietic progenitor cells2009

    • Author(s)
      Hirabayashi Y, Inoue T
    • Journal Title

      Biochem Pharmacol

      Volume: 77(4) Pages: 521-535

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Journal Article] Aryl hydrocarbon receptor biology and xenobiotic responses in hematopoietic progenitor cells2009

    • Author(s)
      Hirabayashi Y, Inoue T
    • Journal Title

      Biochem Pharmacol

      Volume: 77(4) Pages: 521-535

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Journal Article] Comparison of murine gene expression profiles between spontaneous and radiation- induced myelogenous leukemias : Stochastic and probabilistic expression variances in the former vs radiation-specific expression commonalities in the latter.2009

    • Author(s)
      Hirabayashi Y、Tsuboi I、(6名省略)、Inoue T.
    • Journal Title

      Exp Hematol 37

      Pages: 195-205

    • Data Source
      KAKENHI-PROJECT-18510066
  • [Journal Article] Comparison of murine gene expression profiles between spontaneous and radiation-induced myelogenous leukemias : stochastic and probabilistic expression variances in the former vs. radiation-specific expression commonalities in the latter2009

    • Author(s)
      Hirabayashi Y, Tsuboi I, Kitada K, Igarashi K, Kodama Y, Kanno J, Yoshida K, Dainiak N. Inoue T
    • Journal Title

      Exp Hematol

      Volume: 37(2) Pages: 195-205

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Journal Article] Benzene-induced hematopoietic toxicity transmitted by AhR in wild-type mouse and nullified by repopulation with AhR-deficient bone marrow cells : time after benzene treatment and recovery2008

    • Author(s)
      Hirabayashi Y, Yoon BI, Li GX, Fujii-Kuriyama Y, Kaneko T, Kanno J, Inoue T
    • Journal Title

      Chemosphere

      Volume: 73(1 Suppl)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Journal Article] Benzene-induced hematopoietic toxicity transmitted by AhR in wild-type mouse and nullified by repopulation with AhR-deficient bone marrow cells : time after benzene treatment and recovery.2008

    • Author(s)
      Hirabayashi Y, Yoon BI, Li GX, Fujii-Kuriyama Y, Kaneko T, Kanno J, Inoue T.
    • Journal Title

      Chemosphere 73(1Suppl)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Journal Article] AhR-mediated benzene-induced hematopoietic toxicities: differential toxicities between one from AhR in the hematopoietic stem cells for the bone marrow and the other from possible hepatic- AhR for the peripheral blood.2008

    • Author(s)
      Hirabayashi Y、Yoon BI、(4名省略)、Inoue T.
    • Journal Title

      Organohalogen Compounds 70

      Pages: 287-290

    • Data Source
      KAKENHI-PROJECT-18510066
  • [Journal Article] Benzene-induced hematopoietic toxicity transmitted by AhR in wild-type mouse and nullified by repopulation with AhR-deficient bone marrow cells: time after benzene treatment and recovery.2008

    • Author(s)
      Hirabayashi Y、Yoon BI、(4名省略)、Inoue T.
    • Journal Title

      Chemosphere 73

    • Data Source
      KAKENHI-PROJECT-18510066
  • [Journal Article] Protective role of connexin 32 in steady-state hematopoiesis, regeneration state, and leukemogenesis2007

    • Author(s)
      Hirabayashi Y, Yoon BI, Tsuboi I, Huo Y, Kodama Y, Kanno J, Ott, T, Trosko JE, Inoue T
    • Journal Title

      Exp Biol Med (Maywood) 232

      Pages: 700-712

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590329
  • [Journal Article] p53 (TRP53) deficiency-mediated antiapoptosis escape after 5 Gy X irradiation still induces stem cell leukemia in C3H/He mice : comparison between whole-body assay and bone marrow transplantation (BMT) assay.2007

    • Author(s)
      Yoshida K、Hirabayashi Y、(4名省略)、Inoue T.
    • Journal Title

      Radiat Res 167

      Pages: 703-10

    • Data Source
      KAKENHI-PROJECT-18510066
  • [Journal Article] Aryl hydrocarbon receptor suppresses spontaneous neoplasms and extends life span : possible mechanism implied by hematopoietic stem cell kinetics.2007

    • Author(s)
      Hirabayashi Y、Yoon BI、(3名省略)、Inoue T.
    • Journal Title

      Organohalogen Compounds 69

      Pages: 357-361

    • Data Source
      KAKENHI-PROJECT-18510066
  • [Journal Article] Membrane Channel Connexin 32 Maintains Lin(-)/c-kit (+) Hematopoietic Progenitor Cell Compartment: Analysis of the Cell Cycle.2007

    • Author(s)
      Hirabayashi Y、Yoon BI、Tsuboi I、(5名省略)、Inoue T.
    • Journal Title

      J Membr Biol 217

      Pages: 105-113

    • Data Source
      KAKENHI-PROJECT-18510066
  • [Journal Article] Implications of hemopoietic progenitor cell kinetics and experimental leukemogenesis : Relevance to Gompertzean mortality as possible hematotoxicological endpoint2007

    • Author(s)
      Hirabayashi Y, Inoue T
    • Journal Title

      Exp Hematol 35

      Pages: 125-133

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590329
  • [Journal Article] Protective role of connexin 32 in steady-state hematopoiesis、regeneration state、and leukemogenesis.2007

    • Author(s)
      Hirabayashi Y、Yoon BI、Tsuboi I、(5名省略)、Inoue T.
    • Journal Title

      Exp Biol Med (Maywood) 232

      Pages: 700-12

    • Data Source
      KAKENHI-PROJECT-18510066
  • [Journal Article] Implications of hemopoietic progenitor cell kinetics and experimental leukemogenesis: Relevance to Gompertzean mortality as possible hematotoxicological endpoint.2007

    • Author(s)
      Hirabayashi Y、Inoue T.
    • Journal Title

      Exp Hematol 35

      Pages: 125-33

    • Data Source
      KAKENHI-PROJECT-18510066
  • [Journal Article] Caloric restriction prevents radiation-induced myeloid leukemia in C3H/HeMs mice and inversely increases incidence of tumor-free death: implications in changes in number of hemopoietic progenitor cells.2006

    • Author(s)
      Yoshida K, Hirabayashi Y, Watanabe F, Sado T, Inoue T
    • Journal Title

      Exp Hematol 34(3)

      Pages: 274-283

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510064
  • [Journal Article] Thioredoxin overexpression in mice, model of attenuation of oxidative stress, prevents benzene-induced hemato-lymphoid toxicity and thymic lymphoma2006

    • Author(s)
      Li GX, Hirabayashi Y, Yoon BI, Kawasaki Y, Tsuboi I, Kodama Y, Kurokawa Y, Yodoi J, Kanno J, Inoue T
    • Journal Title

      Exp Hematol 34

      Pages: 1687-1697

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590329
  • [Journal Article] Caloric restriction prevents radiation-induced myeloid leukemia in C3H/HeMs mice and inversely increases incidence of tumor-free death : implications in changes in number of hemopoietic progenitor cells2006

    • Author(s)
      Yoshida K, Hirabayashi Y, Watanabe F, Sado T, Inoue T
    • Journal Title

      Exp Hematol 34

      Pages: 274-283

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590329
  • [Journal Article] 老化と生体異物2006

    • Author(s)
      平林容子、井上達
    • Journal Title

      基礎老化研究 30(4)

      Pages: 9-15

    • Data Source
      KAKENHI-PROJECT-18510066
  • [Journal Article] Tumor suppressor function of aryl hydro- carbon receptor (AhR): early onsets of sponta- neous lymphoma and hepatoma、and resulting shortened life span observed in AhR deficient mice.2006

    • Author(s)
      Hirabayashi Y、Yoon BI、(4名省略)、Inoue T.
    • Journal Title

      Organohalogen Compounds 68

      Pages: 556-559

    • Data Source
      KAKENHI-PROJECT-18510066
  • [Journal Article] Benzene-induced hematopoietic toxicity transmitted by AhR in wild-type mouse nullified by repopulation of AhR deficient bone marrow cells: time after benzene treatment and recovery.2006

    • Author(s)
      Hirabayashi Y, Yoon BI, Li GX, Fujii-Kuriyama Y, Kaneko T, Kanno J, Inoue T
    • Journal Title

      Chemosphere (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510064
  • [Journal Article] Thioredoxin overexpression in mice、model of attenuation of oxidative stress、prevents benzene-induced hemato-lymphoid toxicity and thymic lymphoma.2006

    • Author(s)
      Li GX、Hirabayashi Y、Yoon BI、Kawasaki Y、Tsuboi I、(4名省略)、Inoue T.
    • Journal Title

      Exp Hematol 34

      Pages: 1687-97

    • Data Source
      KAKENHI-PROJECT-18510066
  • [Journal Article] Caloric restriction prevents radiation-induced myeloid leukemia in C3H/HeMs mice and inversely increases incidence of tumor-free death: implications in changes in number of hemopoietic progenitor cells.2006

    • Author(s)
      Yoshida K、Hirabayashi Y、(2名省略)、Inoue T.
    • Journal Title

      Exp Hematol 34

      Pages: 274-83

    • Data Source
      KAKENHI-PROJECT-18510066
  • [Journal Article] Meeting report: Validation of toxicogenomics-based test systems: ECVAM-ICCVAM/NICEATM considerations for regulatory use.2006

    • Author(s)
      Corvi R, Ahr HJ, Albertini S, Blakey DH, Clerici L, Coecke S, Douglas GP, Gribaldo L, Groten JP, Haase B, Hamernik K, Hartung T, Inoue T, Indans I, Maurici D, Orphanides G, Rembges D, Sansone SA, Snape JP, Toda E, Tong W, van Delft JH, Weis B, Schechtman LM
    • Journal Title

      Environ Health Perspect 114(3)

      Pages: 420-429

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510064
  • [Journal Article] Tumor suppressor function of aryl hydrocarbon receptor (AhR) : early onsets of spontaneous lymphoma and hepatoma, and resulting shortened life span observed in AhR deficient mice2006

    • Author(s)
      Hirabayashi Y, Yoon BI, Li GX, Fujii-Kuriyama Y, Kaneko T, Kanno J, Inoue T
    • Journal Title

      Organohalogen Compounds 68

      Pages: 556-559

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590329
  • [Journal Article] Meeting report : Validation of toxicogenomics-based test systems: ECVAM-ICCVAM/NICEATM considerations for regulatory use.2006

    • Author(s)
      Corvi R、(11名省略)、Inoue T、(10名省略)、Schechtman LM.
    • Journal Title

      Environ Health Perspect 114

      Pages: 420-9

    • Data Source
      KAKENHI-PROJECT-18510066
  • [Journal Article] Effects of neopterin on the hematopoietic microenvironment of senescence-accelerated mice (SAM).2006

    • Author(s)
      Kanbe E, Hatta Y, Tsuboi I, Harada T, Koshinaga M, Inoue T, Aizawa S
    • Journal Title

      Biol Pharm Bull 29(1)

      Pages: 43-48

    • NAID

      110005602080

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510064
  • [Journal Article] Benzene-induced hematopoietic toxicity transmitted by AhR in the wild-type mouse was negated by repopulation of AhR deficient bone marrow cells2005

    • Author(s)
      Hirabayashi Y, Yoon BI, Li GX, Fujii-Kuriyama Y, Kaneko T, Kanno J, Inoue T
    • Journal Title

      Organohalogen Compounds 67

      Pages: 2280-2283

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590329
  • [Journal Article] Benzene-induced hematopoietic toxicity transmitted by AhR in the wild-type mouse was negated by repopulation of AhR deficient bone marrow cells.2005

    • Author(s)
      Hirabayashi Y, Yoon BI, Li GX, Fujii-Kuriyama Y, Kaneko T, Kanno J, Inoue T
    • Journal Title

      Organohalogen Compounds 67

      Pages: 2280-2283

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510064
  • [Journal Article] Differential contributions of Mesp 1 and Mesp2 to the epithelialization and rostro-caudal patterning of somites.2005

    • Author(s)
      Takahashi Y, Kitajima S, Inoue T, Kanno J, Saga Y
    • Journal Title

      Development 132(4)

      Pages: 787-796

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510064
  • [Journal Article] Electron microscopical evidence of the protective function of thioredoxin (Trx/ADF) transgene against 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD)-induced cellular toxicity in the liver and brain2005

    • Author(s)
      Yoon BI, Kaneko T, Hirabayashi Y, Imazawa T, Nishikawa A, Kodama Y, Kanno J, Yodoi J, Han JH, Hirose M, Inoue T
    • Journal Title

      J Toxicol Pathol 18

      Pages: 41-46

    • NAID

      10025852625

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590329
  • [Journal Article] Eloctron microscopical evidence of the protective function of thioredoxin (Trx/ADF) transgene against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced cellular toxicity in the liver and brain.2005

    • Author(s)
      Yoon BI, Kaneko T, Hirabayashi Y, Imazawa T, Nishikawa A, Kodama Y, Kanno J, Yodoi J, Han JH, Hirose M, Inoue T
    • Journal Title

      J Toxicol Pathol 18

      Pages: 41-46

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510064
  • [Journal Article] Chapter 24. Toxicogenomics Applied to Hematotoxicology. In: Borlak J, ed.Handbook of Toxicogenomics.2005

    • Author(s)
      Hirabayashi Y, Inoue T
    • Journal Title

      Weinheim: Wiley-VCH, Verlag GmbH

      Pages: 583-608

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590329
  • [Journal Article] MX, a by-product of water chlorination, lacks in vivo genotoxicity in gpt delta mice but inhibits gap junctional intercellular communication in rat WB cells.2005

    • Author(s)
      Nishikawa A, Sai K, Okazaki K, Son HY, Kanki K, Nakajima M, Kinae N, Nohmi T, Trosko JE, Inoue T, Hirose M
    • Journal Title

      Environ Mol Mutagen

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510064
  • [Journal Article] The utility of genetically modified mouse assays for identifying human carcinogens: a basic understanding and path forward. The Alternatives to Carcinogenicity Testing Committee ILSI HESI.2004

    • Author(s)
      MacDonald J, French JE, Gerson RJ, Goodman J, Inoue T, Jacobs A, Kasper P, Keller D, Lavin A, Long G, McCullough B, Sistare FD, Storer R, van der Laan JW
    • Journal Title

      Toxicol Sci 77(2)

      Pages: 188-194

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510064
  • [Journal Article] Senescent B Lymphopoiesis Is Balanced in Suppressive Homeostasis: Decrease in Interleukin-7 and Transforming Growth Factor-beta Levels in Stromal Cells of Senescence-Accelerated Mice.2004

    • Author(s)
      Tsuboi I, Morimoto K, Hirabayashi Y, Li GX, Aizawa S, Mori KJ, Kanno J, Inoue T
    • Journal Title

      Exp Biol Med (Maywood) 229(6)

      Pages: 494-502

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510064
  • [Journal Article] Exacerbation of benzene pneumotoxicity in connexin 32 knockout mice: enhanced proliferation of CYP2E1-immunoreactive alveolar epithelial cells.2004

    • Author(s)
      Yoon BI, Hirabayashi Y, Kawasaki Y, Tsuboi I, Ott T, Kodama Y, Kanno J, Kim DY, Willecke K, Inoue T
    • Journal Title

      Toxicology 195(1)

      Pages: 19-29

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510064
  • [Journal Article] Mouse Nkdl, a Wnt antagonist, exhibits oscillatory gene expression in the PSM under the control of Notch signaling.2004

    • Author(s)
      Ishikawa A, Kitajima S, Takahashi Y, Kokubo H, Kanno J, Inoue T, Saga Y
    • Journal Title

      Mech Dev 121(12)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510064
  • [Journal Article] Mechanism of benzene-induced hematotoxicity and leukemogenicity: current review with implication of microarray analyses.2004

    • Author(s)
      Hirabayashi Y, Yoon BI, Li GX, Kanno J, Inoue T
    • Journal Title

      Toxicol Pathol 32 Suppl 2

      Pages: 12-16

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510064
  • [Journal Article] Mechanism of benzene-induced hematotoxicity and leukemogenicity: current review with implication of microarray analyses.2004

    • Author(s)
      Hirabayashi Y, Yoon BI, Li GX, Kanno J, Inoue T
    • Journal Title

      Toxicol Pathol 32 Suppl 2

      Pages: 12-6

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590329
  • [Journal Article] Hormonally active agents and plausible relationships to adverse effects on human health.2003

    • Author(s)
      Inoue T
    • Journal Title

      Pure Appl Chem 75(11-12)

      Pages: 2555-2561

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510064
  • [Journal Article] Mechanisms of benzene-induced hematotoxicity and leukemogenicity: cDNA microarray analyses using mouse bone marrow tissue.2003

    • Author(s)
      Yoon BI, Li GX, Kitada K, Kawasaki Y, Igarashi K, Kodama Y, Inoue T, Kobayashi K, Kanno J, Kim DY, Inoue T, Hirabayashi Y
    • Journal Title

      Environ Health Perspect 111(11)

      Pages: 1411-1420

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510064
  • [Journal Article] Health hazards of enocrine-disrupting chemicals on humans as examined from the standpoints of their mechanisms of action.2003

    • Author(s)
      Inoue T, Igarashi K, Sekizawa J
    • Journal Title

      JMAJ (Japan Mecical Association Journal) 46

      Pages: 97-102

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510064
  • [Journal Article] Evaluation of nonthreshold leukemogenic response to methyl nitrosourea in p53-deficient C3H/He mice.2003

    • Author(s)
      Hirabayashi Y, Yoshida K, Aizawa S, Kodama Y, Kanno J, Kurokawa Y, Yoshimura I, Inoue T
    • Journal Title

      Toxicol Appl Pharmacol 190(3)

      Pages: 251-261

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510064
  • [Journal Article] Feedback loops comprising D111, D113 and Mesp2, and differential involvement of Psen1 are essential for rostrocaudal patterning of somites.2003

    • Author(s)
      Takahashi Y, Inoue T, Gossler A, Saga Y
    • Journal Title

      Development 130(18)

      Pages: 4259-4268

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510064
  • [Journal Article] Hormonally active agents and plausible relationships to adverse effects on human health.2003

    • Author(s)
      Inoue T
    • Journal Title

      Pure Appl Chem 77(11-129

      Pages: 2555-2561

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15510064
  • [Journal Article] AhR suppresses hemopoiesis during steady state but accelerates cell cycle as an early response: a study of AhR-knockout mice.2003

    • Author(s)
      Hirabayashi Y, Yoon BI, Li GX, Fujii-Kuriyama Y, Kaneko T, Kanno J, Inoue T
    • Journal Title

      Organohalogen Compounds 64

      Pages: 270-273

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510064
  • [Journal Article] Targeted disruption of oncostatin M receptor results in altered hematopoiesis.2003

    • Author(s)
      Tanaka M, Hirabayashi Y, Sekiguchi T, Inoue T, Katsuki M, Miyajima A
    • Journal Title

      Blood 102(9)

      Pages: 3154-3162

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510064
  • [Patent] 発がんプロモーター作用の測定法2008

    • Inventor(s)
      佐井君江、菅野 純、井上達
    • Industrial Property Rights Holder
      国立医薬品食品衛生研究所所長
    • Acquisition Date
      2008-08-22
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Presentation] Comparison of microarray gene expression profiles corresponding to xenobiotic responses to oxidative stresses induced by ionizing radiation and benzene treatment2012

    • Author(s)
      Hirabayashi1 Y, Li GX, Igarashi1 K, Kanno J, Yodoi J, Inoue T
    • Organizer
      Society of Toxicology 51^<st> Annual Meeting & ToxExpo
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2012-03-14
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Presentation] Comparison of microarray gene expression profiles corresponding to xenobiotic responses to oxidative stresses induced by ionizing radiation and benzene treatment2012

    • Author(s)
      Hirabayashi1 Y, Li GX, Igarashi1 K, Kanno J, Yodoi J, Inoue T
    • Organizer
      Society of Toxicology 51^<st> Annual Meeting & ToxExpo
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2012-03-14
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Presentation] Hematopoietic stroma and niches form a generation-age structure, based on the stem/progenitor cell differentiation, separated by heterogeneous functional compartment2012

    • Author(s)
      Inoue T, Otsuka K, Tsuboi I, Aizawa S, Hirabayashi Y
    • Organizer
      Society of Toxicology 51^<st> Annual Meeting & ToxExpo
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2012-03-12
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Presentation] Hematopoietic stroma and niches form a generation-age structure, based on the stem/progenitor cell differentiation, separated by heterogeneous functional compartment2012

    • Author(s)
      Inoue T, et al
    • Organizer
      Society of Toxicology 51^<st> Annual Meeting & ToxExpo
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2012-03-12
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Presentation] A comparison of microarray gene expressions at leukemogenic doses between ionizing radiation and benzene exposure2011

    • Author(s)
      Hirabayashi Y, Yoon B-I, Li G-X, Igarashi K, Ogawa Y, Kanno J, Yodoi J, Inoue T
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-15
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Presentation] 放射線とベンゼンの酸化的障害性遺伝子発現マーカープロファイリングの比較探索2011

    • Author(s)
      井上達, 他
    • Organizer
      第38回日本トキシコロジー学会学術年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-07-11
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Presentation] 放射線照射後のマウスの骨髄に見られる、ストカスティックな遺伝子発現プロフィール2011

    • Author(s)
      井上達, 他
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-04-30
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Presentation] 放射線とベンゼンの酸化的障害性遺伝子発現マーカープロファイリングの比較探索2011

    • Author(s)
      井上達, 他
    • Organizer
      第38回日本トキシコロジー学会学術年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-07-11
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Presentation] Commonality and stochasticity in gene expression profiles during aging process2011

    • Author(s)
      Inoue T, Hirahayashi Y
    • Organizer
      Society of Toxicology 50^<th> Annual Meeting & ToxExpo
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-03-07
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Presentation] Commonality and stochasticity in gene expression profiles during aging process2011

    • Author(s)
      Inoue T, Hirabayashi Y
    • Organizer
      Society of Toxicology 50^<th> Annual Meeting & ToxExpo
    • Place of Presentation
      Washington DC.USA
    • Year and Date
      2011-03-07
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Presentation] 放射線とベンゼンの白血病誘発用量における酸化的障害性遺伝子発現マーカープロファイリングの比較探索2011

    • Author(s)
      井上達, 他
    • Organizer
      第73回日本血液学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-15
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Presentation] Radiation and senescence : Deceleration of cell-cycle in primitive hemopoietic progenitors (CFUS13) was only significant parameter during aging, which was reactively accelerated after 2Gy whole-body irradiation.2011

    • Author(s)
      Hirabayashi Y, Tsuboi I, Sekita K, Kanno J, Kusunoki Y, Inoue T
    • Organizer
      Society of Toxicology 50^<th> Annual Meeting & ToxExpo
    • Place of Presentation
      Washington DC, USA.
    • Year and Date
      2011-03-08
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Presentation] 放射線とベンゼンの白血病誘発用量における酸化的障害性遺伝子発現マーカープロファイリングの比較探索2011

    • Author(s)
      井上達, 他
    • Organizer
      第73回日本血液学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-15
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Presentation] 放射線照射後のマウスの骨髄に見られる、ストカスティックな遺伝子発現プロフィール2011

    • Author(s)
      井上達, 他
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-04-30
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Presentation] A comparison of microarray gene expressions at leukemogenic doses between ionizing radiation and benzene exposure2011

    • Author(s)
      Hirabayashi Y, Yoon B-I, Li G-X, Igarashi K, Ogawa Y, Kanno J, Yodoi J, Inoue T.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-15
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Presentation] Radiation and senescence : Deceleration of cell-cycle in primitive hemopoietic progenitors(CFU-S13) was only significant parameter during aging, which was reactively accelerated after 2Gy whole-body irradiation2011

    • Author(s)
      Hirabayashi Y, Tsuboi I, Sekita K, Kanno J, Kusunoki Y, Inoue T
    • Organizer
      Society of Toxicology 50^<th> Annual Meeting & ToxExpo
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-03-08
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Presentation] Commonality and stochasticity in gene expression profiles during aging process2011

    • Author(s)
      Inoue T, Hirabayashi Y
    • Organizer
      Society of Toxicology 50^<th> Annual Meeting & ToxExpo
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-03-07
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Presentation] ベンゼンの造血障害に対する多環芳香族炭化水素受容体の関与と骨髄特異的異物代謝 続報2010

    • Author(s)
      井上達, 他
    • Organizer
      第37回日本トキシコロジー学会学術年会
    • Place of Presentation
      宜野湾
    • Year and Date
      2010-06-17
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Presentation] Strain differences of the effect of benzene exposure : microarray study of the bone marrow in C57BL/6 and C3H/He mice.2010

    • Author(s)
      Hirabayashi Y, Yoon BI, Igarashi K, Kodama Y, Sekita K, Kaneko T, Kanno J, Inoue T
    • Organizer
      IUTOX 2010-XII International Congress of Toxicology
    • Place of Presentation
      Barcelona, Spain.
    • Year and Date
      2010-07-21
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Presentation] 加齢に特徴的な2種の発現遺伝子プロファイリング : Common aging profileとstochastic wing prulile2010

    • Author(s)
      井上達, 他
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-29
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Presentation] Commonality and stochasticity in gene expression profiles during aging2010

    • Author(s)
      Inoue T, Hirabayashi Y
    • Organizer
      BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Presentation] Strain differences of the effect of benzene exposure : microarray study of the bone marrow in C57BL/6 and C3H/He mice2010

    • Author(s)
      Hirabayashi Y, Yoon BI, Igarashi K, Kodama Y, Sekita K, Kaneko T, Kanno J, Inoue T
    • Organizer
      IUTOX 2010-XII International Congress of Toxicology
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-07-21
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Presentation] Strain differences of the effect of benzene exposure : microarray study of the bone marrow in C57BL/6 and C3H/He mice2010

    • Author(s)
      Hirabayashi Y, Yoon BI, Igarashi K, Kodama Y, Sekita K, Kaneko T, Kanno J, Inoue T
    • Organizer
      IUTOX 2010-XII International Congress of Toxicology
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-07-21
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Presentation] Gene Expression Profile of the Bone Marrow after Exposure in C57BL/6 and C3H/He Mice : Elucidation of strain difference by microarray study with reciprocal gene expression profile, the common gene expression and the stochastic gene expression2010

    • Author(s)
      井上達
    • Organizer
      Society of Toxicology 49^<th> Annual Meeting & ToxExpo
    • Place of Presentation
      Salt Lake City UT, USA
    • Year and Date
      2010-03-09
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Presentation] Gene Expression Profile of the Bone Marrow after Exposure in C57BL/6 and C3H/He Mice : Elucidation of strain difference by microarray study with reciprocal gene expression profile, the common gene expression and the stochastic gene expression2010

    • Author(s)
      井上達
    • Organizer
      Society of Toxicology 49^<th> Annual Meeting & ToxExpo
    • Place of Presentation
      Salt Lake City UT, USA
    • Year and Date
      2010-03-09
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Presentation] Commonality and stochasticity in gene expression profiles during aging.2010

    • Author(s)
      Inoue T, Hirabayashi Y
    • Organizer
      BMB2010(第33回日本分子生物学会年会第83回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Presentation] ベンゼンの造血障害に対する多環芳香族炭化水素受容体の関与と骨髄特異的異物代謝続報2010

    • Author(s)
      井上達, 他
    • Organizer
      第37回日本トキシコロジー学会学術年会
    • Place of Presentation
      宜野湾
    • Year and Date
      2010-06-17
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Presentation] Commonality and stochasticiry in gene expression profiles during aging.2010

    • Author(s)
      Inoue T, Hirabayashi Y
    • Organizer
      BMB 2010(第33回日本分7生物学会年会第83回日本生化学会大会合同大会)
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Presentation] 加齢に特徴的な2種の発現遺伝子プロファイリング : Common aging profileとstochastic aging profile2010

    • Author(s)
      井上達, 他
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-29
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Presentation] Gene expression profile of the bone marrow after benzene exposure in C57BL/6 and C3H/He mice : the common gene expression and the stochastic gene expression2009

    • Author(s)
      Inoue T
    • Organizer
      FDA-China International Forum and Workshop Microarray-Bioinformatics-Next-Generation Sequencing in Safety Assessment and Biomarker discovery
    • Place of Presentation
      Shanghai, China
    • Year and Date
      2009-09-26
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Presentation] 放射線の酸化的DNA障害によって引き起こされるストカスティックな発現遺伝子プロファイリング2009

    • Author(s)
      井上達
    • Organizer
      第71回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-25
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Presentation] 骨髄細胞における加齢に伴う発現遺伝子プロファイリングの特徴:Common aging profile と stochastic aging profile2009

    • Author(s)
      井上達
    • Organizer
      第36回日本トキシコロジー学会学術年会
    • Place of Presentation
      盛岡
    • Year and Date
      2009-07-06
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Presentation] Benzene-induced hematopoietic neoplasms developed in C3H/He and C57BL/6 mice : Differences observed using microarrays2009

    • Author(s)
      井上達
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-09
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Presentation] Thioredoxin-overexpression mice prevent benzene-induced lymphoma/leukemias : Experimental model for possible beneficial role in anti-oxidative stress by broccoli(Sulforaphan)2009

    • Author(s)
      井上達
    • Organizer
      Asia Pacific Symposium on Food Safety 2009
    • Place of Presentation
      Seoul
    • Year and Date
      2009-11-13
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Presentation] Benzene-induced hematopoietic neoplasms developed in C3H/He and C57BL/6mice : Differences observed using microarrays2009

    • Author(s)
      井上達
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-09
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Presentation] 骨髄細胞における加齢に伴う発現遺伝子プロファイリングの特徴:Common aging profile と stochastic aging profile2009

    • Author(s)
      井上達
    • Organizer
      第36回日本トキシコロジー学会学術年会
    • Place of Presentation
      盛岡
    • Year and Date
      2009-07-06
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Presentation] Benzene Induced Myeloid leukemia Revisited, Based on Induction of Thioredoxin2009

    • Author(s)
      Inoue T
    • Organizer
      2009 Autumn Symposium, Korean Society of Toxicology/Korean Society of Environ-mental Mutagens and Carcinogens/Korean Society of Environmental Toxicology
    • Place of Presentation
      Seoul, South Korea
    • Year and Date
      2009-11-13
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Presentation] Hematopoietic neoplastic diseases in C3H/He and C57BL/6 mice after benzene exposure. Differences observed using microarrays2009

    • Author(s)
      井上達
    • Organizer
      Benzene 2009 : Health Effects and Mechanisms of Bone Marrow Toxicity, Implication for t-AML and the Mode of Action Framework
    • Place of Presentation
      Munich
    • Year and Date
      2009-09-10
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Presentation] Induced Myeloid leukemia Revisited, Based on Induction of Thioredoxin2009

    • Author(s)
      井上達
    • Organizer
      2009 Autumn Symposium, Korean Society of Toxicology/ Korean Society of Environmental Mutagens and Carcinogens/ Korean Society of Environmental Toxicology
    • Place of Presentation
      Seoul
    • Year and Date
      2009-11-13
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Presentation] Thioredoxin-overexpression mice prevent benzene-induced lymphoma/leukemias : Experimental model for possible beneficial role in anti-oxidative stress by broccoli(Sulfo-raphan)2009

    • Author(s)
      Inoue T, Hirabayashi Y
    • Organizer
      Asia Pacific Symposium on Food Safety 2009
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2009-11-13
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Presentation] 放射線の酸化的DNA障害によって引き起こされるストカスティックな発現遺伝子プロファイリング2009

    • Author(s)
      井上達
    • Organizer
      第71回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-25
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Presentation] Hematopoietic neoplastic diseases in C3H/He and C57BL/6 mice after benzene exposure. Differences observed using microarrays2009

    • Author(s)
      井上達
    • Organizer
      Benzene 2009 : Health Effects and Mechanisms of Bone Marrow Toxicity, Implication for t-AML and the Mode of Action Framework
    • Place of Presentation
      Munich
    • Year and Date
      2009-09-10
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Presentation] C57BL/6およびC3H/He2系統のp53欠失マウスを用いたベンゼン吸引性造血器腫瘍発症の系統差に関する要因解析2009

    • Author(s)
      井上達
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-05-03
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Presentation] Biological Safety Testing in the 21^<st> Century : Overview of the past and prospects for the future2009

    • Author(s)
      井上達
    • Organizer
      10th Annual Commemorative Drug Nonclinical Safety Academic Conference, National Center for Safety Evaluation of Drugs Foundation(NCSEDF)
    • Place of Presentation
      Beijing
    • Year and Date
      2009-12-02
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Presentation] Thioredoxin-overexpression mice prevent benzene-induced lymphoma/leukemias : Experimental model for possible beneficial role in anti-oxidative stress by broccoli (Sulforaphan).2009

    • Author(s)
      Inoue T, Hirabayashi Y
    • Organizer
      Asia Pacific Symposium on Food Safety 2009
    • Place of Presentation
      Seoul, Korea.
    • Year and Date
      2009-11-13
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Presentation] Thioredoxin-overexpression mice prevent benzene-induced lymphoma/leukemias : Experimental model for possible beneficial role in anti-oxidative stress by broccoli(Sulforaphan)2009

    • Author(s)
      井上達
    • Organizer
      Asia Pacific Symposium on Food Safety 2009
    • Place of Presentation
      Seoul
    • Year and Date
      2009-11-13
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Presentation] Hematopoietic neoplastic diseases in C3H/He and C57BL/6 mice after benzene exposure. Differences observed using microarrays2009

    • Author(s)
      Inoue T
    • Organizer
      Benzene 2009 : Health Effects and Mechanisms of Bone Marrow Toxicity, Implication for t-AML and the Mode of Action Framework
    • Place of Presentation
      Munich, Germany
    • Year and Date
      2009-09-10
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Presentation] Biological Safety Testing in the 21^<st> Century : Overview of the past and prospects for the future2009

    • Author(s)
      Inoue T
    • Organizer
      The 10^<th> Annual Commemorative Drug Nonclinical Safety Academic Conference, National Center for Safety Evaluation of Drugs Foundation(NCSEDF)
    • Place of Presentation
      Beijing, China
    • Year and Date
      2009-12-02
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Presentation] C57BL/6およびC3H/He2系統のp53欠失マウス用いたベンゼン吸引性造血器腫瘍発症の系統差に関する要因解析2009

    • Author(s)
      井上達
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-05-03
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Presentation] Thioredoxin-over-expression mice prevent benzene-induced lymphoma/leukemias : Experimental model for possible beneficial role in anti-oxidative stress by broccoli(Sulforaphan)2009

    • Author(s)
      Inoue T, Hirabayashi Y
    • Organizer
      Asia Pacific Symposium on Food Safety 2009
    • Place of Presentation
      Seoul, South Korea
    • Year and Date
      2009-11-13
    • Data Source
      KAKENHI-PROJECT-21510074
  • [Presentation] Y:Gompertzean expression of the life span: Toxicological ultimate risk for xenobiotic responses.2008

    • Author(s)
      Inoue T、Hirabayashi Y
    • Organizer
      The 45^<th> Congress of the European Societies of Toxicology
    • Place of Presentation
      Athens, Greece
    • Year and Date
      2008-10-06
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Presentation] チオレドキシン(Trx)遺伝子改変(ノックアウト及び過剰発現)マウスにおける異物相互作用2008

    • Author(s)
      平林容子、尹秉一、(3名省略)、井上達
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-11
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Presentation] Connexin 32 maintains quiescent hematopoietic progenitor cells in Lin^-/c-kit^+/Sca1^+ fraction : Analysis of the cell cycle.2008

    • Author(s)
      Hirabayashi Y, Yoon BI, Tsuboi I, Ott T, Trosko JE, Inoue T
    • Organizer
      6^<th> ISSCR Annual Meeting
    • Place of Presentation
      Cairns, Australia.
    • Year and Date
      2008-06-14
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Presentation] Connexin 32 maintains quiescent hematopoietic progenitor cells in Lin^-/c-kit^+/Sca1^+fraction : Analysis of the cell cycle2008

    • Author(s)
      Hirabayashi Y, Yoon BI, Tsuboi I, Huo Y, Kodama Y, Kanno J, Ott T, Trosko JE, Inoue T
    • Organizer
      6^<th> ISSCR Annual Meeting
    • Place of Presentation
      Cairns, Australia
    • Year and Date
      2008-06-14
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Presentation] ベンゼンの造血障害発現機構 : 多環芳香族炭化水素受容体の関与と骨髄特異的異物代謝続報2008

    • Author(s)
      井上達、尹秉一、(3名省略)、平林容子
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-12
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Presentation] Benzene-inhalation enhanced the incidence of hematopoietic neoplasms in p53-deficient mice with respect to strain- differences between C57BL/6 and C3H/He.2008

    • Author(s)
      Hirabayashi Y、Yoon BI、Tsuboi I、(2名省略)、Inoue T
    • Organizer
      Society of Toxicology 47^<th> Annual Meeting & ToxExpo
    • Place of Presentation
      Seattle WA
    • Year and Date
      2008-03-16
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Presentation] Role of Cx32 in steady-state hematopoiesis and leukemogenesis : study in the Cx32-knockout mice.2008

    • Author(s)
      Hirabayashi Y、Yoon BI、Tsuboi I、(2名省略)、Inoue T
    • Organizer
      Society of Toxicology 47^<th> Annual Meeting & ToxExpo
    • Place of Presentation
      Seattle,WA
    • Year and Date
      2008-03-16
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Presentation] Hirabayashi Y、Yoon BI、(4名省略)、Inoue T2008

    • Author(s)
      Hirabayashi Y、Yoon BI、(4名省略)、Inoue T
    • Organizer
      28^<th> International Symposium on Halogenated Environmental Organic Pollutants and POPs (Dioxin 2008)
    • Place of Presentation
      Birmingham, UK
    • Year and Date
      2008-08-19
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Presentation] ベンゼンの造血障害発現機構:多環芳香族炭化水素受容体の関与と骨髄特異的異物代謝 続報2008

    • Author(s)
      井上達
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-12
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Presentation] 一般口演「血液2」ベンゼン誘発白血病の分子機構 : チオレドキシン過剰発現によるROS消去と白血病の抑制2008

    • Author(s)
      平林容子、李光勲、尹秉一、(3名省略)、井上達
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2008-05-16
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Presentation] Gompertzean expression of the life span : Toxicological ultimate risk for xenobiotic responses2008

    • Author(s)
      Inoue, T.
    • Organizer
      The 45^<th> Congress of the European Societies of Toxicology
    • Place of Presentation
      Athens, Greece
    • Year and Date
      2008-10-06
    • Data Source
      KAKENHI-PROJECT-20590388
  • [Presentation] ベンゼンの造血障害発現機構:多環芳香族炭化水素受容体の関与と骨髄特異的異物代謝 続報2008

    • Author(s)
      井上達
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-12
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Presentation] Benzene-induced hematopoietic impairment is mediated by aryl hydrocarbon receptor (AhR) function compartmentalized in the bone marrow.2008

    • Author(s)
      Hirabayashi Y、Yoon BI、(4名省略)、Inoue T
    • Organizer
      The 37^<th> Annual Scientific Meeting
    • Place of Presentation
      Boston, MA
    • Year and Date
      2008-07-09
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Presentation] Gompertzean expression of the life span : Toxicological ultimate risk for xenobiotic responses2008

    • Author(s)
      Inoue, T.
    • Organizer
      The 45^<th> Congress of the European Societies of Toxicology
    • Place of Presentation
      Athens, Greece
    • Year and Date
      2008-10-06
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Presentation] ゴンパーツ函数を指標とした生体異物相互作用の加齢に及ぼす影響2007

    • Author(s)
      井上達、平林容子
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-14
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Presentation] Aryl hydrocarbon receptor suppresses spontaneous neoplasms and extends life span: possible mechanism implied by hematopoietic stem cell kinetics.2007

    • Author(s)
      Hirabayashi Y、Yoon BI、(3名省略)、Inoue T
    • Organizer
      27th International Symposium on Halogeneated Environmental Organic Pollutants and POPs (Dioxin 2007)
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-09-04
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Presentation] Attenuation of oxidative stress in the Trx-overexpression mice:Study on benzene induced hemopoietic malignancies2007

    • Author(s)
      Inoue T, et. al.
    • Organizer
      The 4^<th> Meeting of lnternational REDOX Network
    • Place of Presentation
      Jeju lsland,Korea
    • Year and Date
      2007-11-02
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Presentation] 一般口演「腫瘍3」芳香族炭化水素受容体(AhR)の細胞周期抑制を介した腫瘍サプレッサー機能2007

    • Author(s)
      平林容子、(4名省略)、井上達
    • Organizer
      第96回日本病理学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-14
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Presentation] ベンゼンの造血障害発現機構 : 多環芳香族炭化水素受容体の関与と骨髄特異的異物代謝の関与の役割について2007

    • Author(s)
      井上達、尹秉一、(3名省略)、平林容子
    • Organizer
      第69回日本血液学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-11
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Presentation] A new toxicological biomarker, connexin 32, in the hematopoietic stem cells: the deficiency induced a prolongation of chemical damage and an increased incidence of leukemogenesis.2007

    • Author(s)
      Hirabayashi Y、Yoon BI、Tsuboi I、(5名省略)、Inoue T
    • Organizer
      International Congress of Toxicology XI
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2007-07-18
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Presentation] 話題提供「老化と環境化学物質生体応答」2007

    • Author(s)
      井上達、平林容子
    • Organizer
      日本基礎老化学会第30回大会
    • Place of Presentation
      札幌
    • Year and Date
      2007-06-22
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Presentation] AhR, a suppressor gene: mice with low AhR or KO exhibit a shortened lifespan with early onset of spontaneous neoplasms.2007

    • Author(s)
      井上達、尹秉一、(5名省略)、平林容子
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Presentation] Hemopoietic progenitors express aryl hydro- carbon receptors that suppress the cell cycle, thereby restoring their stemness.2007

    • Author(s)
      平林容子、尹秉一、(5名省略)、井上達
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Presentation] 基調講演海外における化学物質の内分泌かく乱作用に関する取り組みWHO/IPCSの取り組み2007

    • Author(s)
      井上達
    • Organizer
      化学物質の環境リスクに関する国際シンポジウム化学物質の内分泌かく乱作用について~10年間のあゆみ~
    • Place of Presentation
      大宮
    • Year and Date
      2007-12-09
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Presentation] Attenuation of oxidative stress in the Trx-overexpression mice : Study on benzene induced hemopoietic malignancies.2007

    • Author(s)
      Inoue T
    • Organizer
      The 4^<th> Meeting of International REDOX Network
    • Place of Presentation
      Jeju Island, Korea
    • Year and Date
      2007-11-02
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Presentation] Effect of endocrine disruptors on health : possible underlying mechanistic background of low-dose and synergistic actions.2006

    • Author(s)
      Inoue T
    • Organizer
      Weybridge+10 Workshop Impacts of Endocrine Disrupters
    • Place of Presentation
      Helsinki, Finland
    • Year and Date
      2006-11-10
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Presentation] Possible stem cell-specific xenobiotic metabolism in the bone marrow.2006

    • Author(s)
      Hirabayashi Y, Yoon BI、(4名省略)、Inoue T
    • Organizer
      International Society of Stem Cell Research 4^<th> ISSCR Annual Meeting
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2006-06-30
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Presentation] アリールハイドロカーボン受容体 : 癌抑制遺伝子モデル2006

    • Author(s)
      平林容子、(5名省略)、井上達
    • Organizer
      第23回日本疾患モデル学会
    • Place of Presentation
      伊香保
    • Year and Date
      2006-11-30
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Presentation] Xenobiotic response gene, aryl hydrocarbon receptor (AhR), plays a tumor suppressive function : an early onset and higher incidence of spontaneous tumori-/leukemogenicity and a consequent shortened lifespan in the AhR knockout mouse.2006

    • Author(s)
      Hirabayashi Y、(5名省略)、Inoue T
    • Organizer
      An AACR Special Conference in Cancer Research "Mouse Models of Cancer"
    • Place of Presentation
      Boston, MA
    • Year and Date
      2006-10-26
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Presentation] AhR mediated hematotoxicity is induced at the site of bone marrow where consequent CYP2E1-derived benzene metabolites locally induce their toxicity.2006

    • Author(s)
      Hirabayashi Y、Yoon BI、(4名省略)、Inoue T
    • Organizer
      Society of Toxicology 45^<th> Annual Meeting & ToxExpo
    • Place of Presentation
      San Diego, CA
    • Year and Date
      2006-03-06
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Presentation] Tumor suppressor function of aryl hydrocarbon receptor (AhR) : early onsets of spontaneous lymphoma and hepatoma, and resulting shortened life span observed in AhR deficient mice.2006

    • Author(s)
      Hirabayashi Y、Yoon BI、(4名省略)、Inoue T
    • Organizer
      26^<th> International Symposium on Halogeneated Environmental Organic Pollutants and POPs (Dioxin 2006)
    • Place of Presentation
      Oslo. Norway
    • Year and Date
      2006-08-22
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Presentation] 教育講演EL2 新しい視点から見たトキシコロジー : 発生・成長・老化2006

    • Author(s)
      井上達
    • Organizer
      第33回日本トキシコロジー学会学術年会
    • Place of Presentation
      名古屋
    • Year and Date
      2006-07-04
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Presentation] ベンゼンの毒性は、骨髄特異的異物代謝によって引き起こされる2006

    • Author(s)
      平林容子、尹秉一、(4名省略)、井上達
    • Organizer
      第33回日本トキシコロジー学会学術年会
    • Place of Presentation
      名古屋
    • Year and Date
      2006-07-05
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Presentation] Summary and Future Directions "Regulation of hematopoiesis".2006

    • Author(s)
      Inoue T
    • Organizer
      Pathophysio- logy & Molecular Biology of Hematopoiesis, Malignancy & Radiation Response "Internatio- nal Symposium in Memory of Eugene P. Cronkite, M.D."
    • Place of Presentation
      Upton, NY
    • Year and Date
      2006-05-12
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Presentation] Global Gene-Expression Profilings of Steady-State Mice Carrying A Graded Dosage of Trx-Gene Elucidate Major Principal Gene-Component for the ROS-removal and for Trx-Dependent Anti-Oxidative Stress.2006

    • Author(s)
      Inoue T, Yoon BI、(3名省略)、Hirabayashi Y
    • Organizer
      20^<th> IUBMB International Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-06-23
    • Data Source
      KAKENHI-PROJECT-18510066
  • [Presentation] 一般口演「造血器・リンパ節・脾臓6」アリールハイドロカーボン受容体の造血細胞での特異な発現とベンゼンの造血障害における役割2006

    • Author(s)
      平林容子、尹秉一、(4名省略)、井上達
    • Organizer
      第95回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2006-04-29
    • Data Source
      KAKENHI-PROJECT-18510066
  • 1.  HIRABAYASHI Yoko (30291115)
    # of Collaborated Projects: 15 results
    # of Collaborated Products: 114 results
  • 2.  SASAKI Hideki (50106316)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 0 results
  • 3.  YOKOTA Takashi (50134622)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 4.  ARAI Ken-ichi (00012782)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 5.  TAKAGI Atsuya (00179417)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 6.  木内 吉寛 (80012764)
    # of Collaborated Projects: 4 results
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  • 7.  梅村 隆志 (50185071)
    # of Collaborated Projects: 4 results
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  • 8.  IKUTA Koichiro (80159590)
    # of Collaborated Projects: 3 results
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  • 13.  MASAI Hisao (40229349)
    # of Collaborated Projects: 2 results
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  • 14.  FUNABIKI Tetsunori (20264616)
    # of Collaborated Projects: 2 results
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  • 15.  KANNO Jun (90186172)
    # of Collaborated Projects: 2 results
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  • 16.  三浦 恭定 (60048965)
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    # of Collaborated Projects: 2 results
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    # of Collaborated Projects: 2 results
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    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 21.  TROSKO James E.
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 22.  TSUBOI Isao (30350028)
    # of Collaborated Projects: 1 results
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  • 23.  NAKAHATA Tatsutoshi (20110744)
    # of Collaborated Projects: 1 results
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  • 24.  WATANABE Sumiko (60240735)
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    # of Collaborated Projects: 1 results
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    # of Collaborated Projects: 1 results
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  • 27.  HASEGAWA Ryuichi (50112496)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  KODAMA Yukio (90170274)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  渡辺 真一郎 (00240490)
    # of Collaborated Projects: 1 results
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  • 30.  蟹沢 成好 (60072972)
    # of Collaborated Projects: 1 results
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  • 31.  佐藤 哲男 (60092061)
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  • 32.  伊藤 隆明 (70168392)
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  • 38.  YOON Byung-il
    # of Collaborated Projects: 1 results
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  • 39.  KANG Kyung-sun
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 40.  TROSKOJAMES ジェームス・イー・
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 41.  松下 智哉
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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