TAKAKU Hiroshi 高久洋

… Alternative Names

高久洋

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Researcher Number	50101267
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2014: 千葉工業大学, 附属研究所, 専任研究員 2012 – 2013: 千葉工業大学, 工学部, 教授 1991 – 1999: 千葉工業大学, 工学部, 教授 1993: 横浜国立大学, 工学部, 教授 1988: 千葉工業大学, 工学部, 助教授
Review Section/Research Field	Principal Investigator 広領域 / Virology Except Principal Investigator Chemical pharmacy
Keywords	Principal Investigator 非イオン界面活性剤 / アンチセンスDNA / マグネシウムイオン / 一価のカチオン / 耐分解酵素性 / 感染細胞 / レトロウイルス / RNase H活性 / センスRNA / RNAキメラオリゴマー … More / 環状DNA / エキソン / イントロン / スプライシング / RNAの特異的切断反応 / RNA / 逆転写酵素 / ヘアピン構造 / 抗HIV活性 / 自己切断反応 / nuclease resistance / HIV-1 infected cells / retrovirus / Rnase H / sense RNA / antisense DNA / DNA chimeric oligonucleotide / circular dumbbell RNA / 耐分解酵素 / RNaseH活性 / HIV-1 vif / HVV-1 / 宿主内因子 / MAGI cells / non-permissive cells / PGA1 / HIV-1 Vif / HIV-1 / HSP70 / APOBEC3G / tRNA^<Tyr> / cDNA / PBS配列 / vRNA / 変異tRNA^<Lys3> / tRNA^<Lys3> / レトロウイルスプライマー / 5'-OH RNA / 2'、3'-環状リン酸 / ピリミジン-アデニン / RNAの位置特異的切断反応 / 二重鎖構造 / DNAキメラ / 逆転写酵素阻害能 / 構造タンパク質遺伝子 / ホスホリピドDNA / ホスホロチオエ-トオリゴマー / RNA酵素 / 逆転者酵素 / アンチセンスDNAの作用機序 / AIDSウイルス / ヘアピン型RNA / 二価のイオン / 一価のイオン / オリゴボヌクレオチド / エイズ / リピドーDNA / ホスホロチオエートオリゴマー / HIVmRNA / 抗HIV剤 … More Except Principal Investigator リボザイム / ヌクレオシド / 核酸の化学合成 / オリゴヌクレオチド / V3loop / エイズ遺伝子治療 / 硫酸アルキルオリゴ糖 / 中和モノクローナル抗体 / クワシスピーシス / Rev / V3 loop / HIV / Tat / 遺伝子治療 / アンチセンス / 阻害剤 / コレセプター / ケモカイン / エイズ / HIV-1 / DNAプローブ / 核酸ループ / インターカレーター / NMR / 機能性核酸 / X線結晶解析 / 触媒RNA / RNA / 核酸高次構造 / RNA化学合成 Less

Screening for novel host factors that regulate HIV-1 replicationPrincipal Investigator
- Principal Investigator
  
  TAKAKU Hiroshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Chiba Institute of Technology
金属イオン-非イオン界面活性剤によるRNAの位置特異的切断反応Principal Investigator
- Principal Investigator
  
  高久洋
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Chiba Institute of Technology
ウイルス感染細胞内でアンチセンス機能を発揮するアンチセンス核酸の構築と感染制御Principal Investigator
- Principal Investigator
  
  高久洋
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Chiba Institute of Technology
エイズの病態と制御に関する基礎研究柱5.感染と病態の制御
- Principal Investigator
  
  YAMAMOTO Naoki
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Medical and Dental University
金属イオン-非イオン界面活性剤によるRNAの位置特異的切断反応Principal Investigator
- Principal Investigator
  
  高久洋
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Chiba Institute of Technology
HIV転写に要求されるtRNA^<Lys3>の構造とその遺伝子発現制御分子としての応用Principal Investigator
- Principal Investigator
  
  高久洋
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Chiba Institute of Technology
Inhibition of HIV-1 replication of an HIV-1 dependent antisense oligonucleotides.Principal Investigator
- Principal Investigator
  
  TAKAKU Hiroshi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  広領域
- Research Institution
  Chiba Institute of Technology
金属イオン-非イオン界面活性剤によるRNAの位置特異的切断反応Principal Investigator
- Principal Investigator
  
  高久洋
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Chiba Institute of Technology
新しいRNAの酵素機能Principal Investigator
- Principal Investigator
  
  高久洋
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Chiba Institute of Technology
抗HIV活性をもつ機能性アンチセンスDNAの合成とその作用機序Principal Investigator
- Principal Investigator
  
  高久洋
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Chiba Institute of Technology
新しいRNAの酵素機能Principal Investigator
- Principal Investigator
  
  高久洋
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Chiba Institute of Technology
機能の創生を目指すオリゴヌクレオチドの化学合成
- Principal Investigator
  
  大塚栄子
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
抗HIV活性をもつ機能性アンチセンスDNAの合成とその作用機序Principal Investigator
- Principal Investigator
  
  高久洋
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Chiba Institute of Technology
新しいRNAの酵素機能Principal Investigator
- Principal Investigator
  
  高久洋
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Chiba Institute of Technology
抗HIV活性をもつ機能性アンチセンスDNAの合成とその作用機序Principal Investigator
- Principal Investigator
  
  高久洋
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Chiba Institute of Technology
新しいRNAの酵素機能Principal Investigator
- Principal Investigator
  
  高久洋
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Chiba Institute of Technology
機能の創生を目指すオリゴヌクレオチドの化学合成
- Principal Investigator
  
  大塚栄子
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
核酸および核酸構成成分の合成と生体機能に関する研究
- Principal Investigator
  
  畑辻明
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo Institute of Technology

All 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] A new role for PGA1 in inhibiting hepatitis C virus-IRES-mediated translation by targeting viral translation factors.2015
- Author(s)
  Tsukimoto A, Sugiyama R, Abe M, Nishitsuji H, Shimizu Y, Shimotohno K, Kawai G, Takaku H.
- Journal Title
  
  Antiviral Res
  
  Volume: 117 Pages: 1-9
- DOI
  10.1016/j.antiviral.2015.01.013
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590557, KAKENHI-PROJECT-26860309
[Journal Article] Prominent steatosis with hypermetabolism of the cell line permissive for years of infection with hepatitis C virus2014
- Author(s)
  Sugiyama, K. Ebinuma, H. Nakamoto, N. Sakasegawa, N. Murakami, Y. Chu, P. S. Usui, S. Ishibashi, Y. Wakayama, Y. Taniki, N. Murata, H. Saito, Y. Fukasawa, M. Saito, K. Yamagishi, Y. Wakita, T. Takaku, H. Hibi, T. Saito, H. Kanai, T.
- Journal Title
  
  PLoS ONE
  
  Volume: 9 Issue: 4 Pages: 849-854
- DOI
  10.1371/journal.pone.0094460
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23590551, KAKENHI-PROJECT-24590557, KAKENHI-PROJECT-24590993
[Journal Article] The RNA-editing enzyme APOBEC1 requires heterogeneous nuclear ribonucleoprotein Q isoform 6 for efficient interaction with interleukin-8 mRNA.2014
- Author(s)
  Shimizu Y, Nishitsuji H, Marusawa H, Ujino S, Takaku H, Shimotohno K.
- Journal Title
  
  J Biol Chem.
  
  Volume: 289 Issue: 38 Pages: 26226-26238
- DOI
  10.1074/jbc.m114.563221
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22114004, KAKENHI-PROJECT-24229005, KAKENHI-PROJECT-24590557
[Journal Article] Induction of heat-shock protein 70 by prostaglandin A, inhibits HIV-1 Vif-mediated degradation of APOBEC3G2013
- Author(s)
  Sugiyama R, Abe M, Nishitsuiji H, Murakami Y, Takeuchi H, Takaku H.
- Journal Title
  
  Antival Res
  
  Volume: 99 Pages: 307-311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590557
[Journal Article] Inhibition of HIV-1 replication by RNA with a microRNA-like function2013
- Author(s)
  Kato K, Senoki T, Takaku H.
- Journal Title
  
  Int J Mol Med.
  
  Volume: 31 Pages: 252-258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590557
[Journal Article] HIV-1 suppressive sequences are modulated by Rev transport of unspliced RNA and are required for efficient HIV-1 production.2012
- Author(s)
  Noguchi K, Ishibashi K, Miyokawa K, Hokari M, Kanno T, Hirano T, Yamamoto N, Takaku H.
- Journal Title
  
  PLoS One
  
  Volume: 7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590557
[Journal Article] ZBRK1 represses HIV-1 LTR-mediated transcription.2012
- Author(s)
  Nishitsuji H, Abe M, Sawada R, Takaku H
- Journal Title
  
  FEBS Lett
  
  Volume: 586 Pages: 3562-3568
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590557
[Presentation] HSP70誘導斉であるProstagradin A1による新規HIV‐1複製抑制機構の解明2013
- Author(s)
  長沼晴樹、杉山隆一、阿部　真、西辻裕紀、小関寛、村上優子、武内覚明、高久洋
- Organizer
  第６１回日本ウイルス学会学術集会
- Place of Presentation
  神戸国際会議場 (兵庫県）
- Data Source
  KAKENHI-PROJECT-24590557
[Presentation] BST2の抗HIV-1活性におけるATPlB3の影響2013
- Author(s)
  阿部真、西辻裕紀、谷口善則、渡退宇裕、高久洋
- Organizer
  第６１回日本ウイルス学会学術集会
- Place of Presentation
  神戸国際会議場 (兵庫県）
- Data Source
  KAKENHI-PROJECT-24590557
[Presentation] ZBRKl represses HIV-l LTR-mediated transcription2013
- Author(s)
  Leila Sawada, ,Hironori Nishistuji, Makoto Abe, Hiroshi Takaku
- Organizer
  23rd Annual Meeting of the Japanese Association for Antiviral Therapy
- Place of Presentation
  リーガロイヤルホテル東京 (東京都）
- Data Source
  KAKENHI-PROJECT-24590557
[Presentation] Evaluation and identification of KRAB-Zinc finger protein influence on HIV-1 gene expression2013
- Author(s)
  Leila Sawada, 西辻裕紀, 阿部真, 高久洋
- Organizer
  第６１回日本ウイルス学会学術集会
- Place of Presentation
  神戸国際会議場 (兵庫県）
- Data Source
  KAKENHI-PROJECT-24590557
[Presentation] HSP70誘導剤；Prostanglandin A1はHIV-1 VifによるAPOBEC3G分解を抑制することでHIV-１複製を阻害する2012
- Author(s)
  杉山　隆一、西辻　裕紀、村上　優子、武内　寛明、脇田　隆宇、高久　洋
- Organizer
  第26回日本エイズ学会学術集会・総会
- Place of Presentation
  慶応義塾大学・日吉キャンパス・横浜・神奈川
- Data Source
  KAKENHI-PROJECT-24590557
[Presentation] Heat Shock Protein 70 Inhibits HIV-1 Vif-Mediated Ubiquitination and Degradation of APOBEC3G2012
- Author(s)
  Ryuichi Sugiyama, Hironori Nishitsuji, Makoto Abe, Masato Katahira, Hiroaki　Takeuchi, Yuichiro Habu, Akihide Ryo, Hiroshi Takaku
- Organizer
  The Twenty-Fifth International　Conference on Antiviral Research (ICAR)
- Place of Presentation
  Royton Sappro・Sapporo・Hokkaido
- Data Source
  KAKENHI-PROJECT-24590557
[Presentation] HSP70誘導剤：Prostaglandin A1による新規HIV-1複製抑制機構の解明
- Author(s)
  杉山隆一, 阿部真, 西辻裕紀, 村上優子, 武内寛明, 高久洋
- Organizer
  第24回抗ウイルス療法研究会総会
- Place of Presentation
  ハイランドリゾートホテル(山梨県、富士吉田市)
- Year and Date
  2014-05-07 – 2014-05-09
- Data Source
  KAKENHI-PROJECT-24590557
[Presentation] Hsp70阻害剤,KNK437によるC型肝ウイルス複製制御の解析
- Author(s)
  月本あつ子、杉山隆一、小倉大直、君塚圭亮、高久洋
- Organizer
  第６２回日本ウイルス学術総会
- Place of Presentation
  パシフィコ横浜　会議センター(神奈川県横浜市)
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-24590557
[Presentation] Effect of HEXIM1 and 7SK snRNA on HIV-1 LTR-driven gene transcription
- Author(s)
  高木啓太, 西辻裕紀, 天野亮,坂本泰一, 高久　洋
- Organizer
  第６２回日本ウイルス学術総会
- Place of Presentation
  パシフィコ横浜　会議センター(神奈川県横浜市)
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-24590557

1. TAKAI Kazuyuki (40260848)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. 大塚栄子 (80028836)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. 中島秀喜 (20192669)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. YAMAMOTO Naoki (00094053)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 上杉晴一 (70028851)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 牧野圭祐 (50159141)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 松本治 (10231599)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 竹中章郎 (80016146)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 島田隆 (20125074)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 伊藤正彦 (90045740)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 松下修三 (00199788)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 志田壽利 (00144395)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 多比良和誠 (10261778)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 畑辻明 (00016049)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 関根光雄 (40111679)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 石戸良治 (60016037)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 上田亨 (00001032)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. ABE Makoto

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
19. CHANG Myitt Oo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. SUGIYAMA Kazuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 斎藤英胤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 下遠野邦忠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAKAKU Hiroshi 高久 洋

高久 洋

Research Projects

Research Products

Co-Researchers

Screening for novel host factors that regulate HIV-1 replicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

金属イオン-非イオン界面活性剤によるRNAの位置特異的切断反応Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

ウイルス感染細胞内でアンチセンス機能を発揮するアンチセンス核酸の構築と感染制御Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

エイズの病態と制御に関する基礎研究 柱5.感染と病態の制御

Principal Investigator

Project Period (FY)

Research Category

Research Institution

金属イオン-非イオン界面活性剤によるRNAの位置特異的切断反応Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

HIV転写に要求されるtRNA^<Lys3>の構造とその遺伝子発現制御分子としての応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Inhibition of HIV-1 replication of an HIV-1 dependent antisense oligonucleotides.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

金属イオン-非イオン界面活性剤によるRNAの位置特異的切断反応Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

新しいRNAの酵素機能Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

抗HIV活性をもつ機能性アンチセンスDNAの合成とその作用機序Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

新しいRNAの酵素機能Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

機能の創生を目指すオリゴヌクレオチドの化学合成

Principal Investigator

Project Period (FY)

Research Category

Research Institution

抗HIV活性をもつ機能性アンチセンスDNAの合成とその作用機序Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

新しいRNAの酵素機能Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

抗HIV活性をもつ機能性アンチセンスDNAの合成とその作用機序Principal Investigator

Principal Investigator

Project Period (FY)

TAKAKU Hiroshi 高久洋

高久洋

エイズの病態と制御に関する基礎研究柱5.感染と病態の制御