KOHNO Takeyuki 河野武幸

… Alternative Names

河野武幸コウノタケユキ

KOUNO Takeyuki 河野武幸

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Researcher Number	50178224
Other IDs
Affiliation (Current)	2025: 一般財団法人生産開発科学研究所, その他部局等, 研究員
Affiliation (based on the past Project Information) *help	2015 – 2018: 摂南大学, 薬学部, 教授 2007 – 2009: Setsunan University, 薬学部, 教授 2001 – 2004: 摂南大学, 薬学部, 助教授 1993 – 2000: 摂南大学, 薬学部, 講師 1987 – 1988: 宮崎医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Laboratory medicine / Medical pharmacy / Biological pharmacy Except Principal Investigator 医薬分子機能学 / Immunology / General medical chemistry / 応用薬理学・医療系薬学 / Synthetic chemistry / Synthetic chemistry / Physical pharmacy
Keywords	Principal Investigator 酵素免疫測定法 / IgA / HLA / 薬剤誘発性血管炎 / 薬剤誘発生血管炎 / 臨床薬学 / ザルトプロフェン / 血管痛 / Diazo-IC / ダカルバジン … More / Cytokines / Enzyme Immunoassay / Mucosal Immunity / Albumin / Type 1 Diabetes Mellitus / サイトカイン / 粘膜免疫 / アルブミン / 1型糖尿病 / Epitope / Autoimmune Diseases / Enzyme immunoassay / Acetylcholine receptor autoantibody / Myasthenia Gravis / 自己免症疾患 / エピトープ / 自己免疫疾患 / アセチルコリン受容体自己抗体 / 重症筋無力症 / ステロイド抵抗性 / Ngaマウス / NC / アトピー性皮膚炎 / FTY720 / バイオアベイラビリティー / 骨粗鬆症 / カルシトニン … More Except Principal Investigator 酵素免疫測定法 / FTY720 / Enzyme immunoassay / Osteoporosis / Bone formation / Bone resorption / Osteoblast / Parathyroid hormone / Calcitonin / 破骨細胞 / 骨粗鬆症 / カルシトニン / ハプテン / モノクローナル抗体 / タキソール / 抗タキソールモノクローナル抗体 / フィンゴリモド / Interleukin-10 / 寛解 / 関節リウマチ / 病因抗原 / 免疫寛容 / interleukin-10 / Radioimmunoassay / Antibody / Anti-insulin IgG / Insulin / 糖尿病 / ラジオイムノアッセイ / 抗体 / 抗インスリン抗体 / インスリン / PHARMACO-BINDING SITE / EIPITOPE ANALYSIS / PHARMACOKINETICS / ORGAN TRANSPLANT / HAPTEN / ENZYME IMMUNOASSAY / IMMUNOSUPPRESSANT / 薬部動態 / 薬物認識部位 / エピトープ解析 / 薬物動態 / 臓器移植 / 免疫抑制剤 / Drug Disposition / IgG Antibody / Protein Drugs / Oral Tolerance / Systemic Immune Response / 経口免疫寛溶 / 体内動態 / IgG抗体 / 蛋白質医薬品 / 経口免疫寛容 / 全身免疫 / Osteoclast / TNF / IFN / 骨形成促進作用 / 副甲状腺ホルモン / Enzyme immuneassay / Parathy roid hormone / Osteo clast / Osteo porosis / enzyme immunoassay / bone absorption / osteoclast / osteomalacia / osteoporosis / calcitonin / 軟骨細胞 / 骨吸収 / 骨軟化症 / ニュートラルスキャン / ニュートラルロススキャン / MS法 / MS / ニュートラルロスキャン / 抗体反応 / ハイブリドーマ / 分子認識 / 立体選択的反応 / Baccatin III / カサランチン / ビンドリン / dihydropyridinium中間体 / anhydrovinblastine / 立体選択的合成 / 反応場 / ビンブラスチン / 抗ビンブラスチンモノクローナル抗体 / 経口ワクチン / AIDS / 経粘膜感染 / 経口感作 / IgA抗体 / 局所免疫 Less

Basic research on new therapeutic strategy for rheumatoid arthritis to induction of immune tolerance
- Principal Investigator
  
  Yoshida Yuya
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Setsunan University
Development of methods for reducing venous pain caused by dacarbazinePrincipal Investigator
- Principal Investigator
  
  KOHNO Takeyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Setsunan University
Attempted synthesis of taxol utilizing anti-taxol monoclonal antibody as a as a chiral mould
- Principal Investigator
  
  UESATO Shinichi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Synthetic chemistry
- Research Institution
  Kansai University
A novel immunomodulator, FTY720, ameliorates spontaneous dermatitis in NC/Nga micePrincipal Investigator
- Principal Investigator
  
  KOHNO Takeyuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Setsunan University
モノクローナル抗体を反応場として用いた天然抗がん剤の新規合成法の開発
- Principal Investigator
  
  UESATO Shinichi
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Synthetic chemistry
- Research Institution
  Kansai University
Establishment and Analysis of Enzym Immunoassay for Novel Immunosuppressant, FTY720
- Principal Investigator
  
  FUJITA Tetsuro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  RESEARCH INSTITUTE FOR PRODUCTION DEVELOPMENT
Development of Mass-Screening Method for the Identification of Patients at Risk of Developing Type 1 Diabetes Mellitus.Principal Investigator
- Principal Investigator
  
  KOHNO Takeyuki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Setsunan University
Use of Oral Tolerance to Improve the Disposition of Protein Drugs in the Body
- Principal Investigator
  
  YAMASHITA Shinji
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Setsunan University
The mode of action, pharmacokinetics and mutual interaction of calcitonin and parathyroid hormone as the anti-osteoporotics
- Principal Investigator
  
  KOIDA Masao
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Setsunan University
Development of ultra-sensitive enzyme immunoassay for anti-acetylcholine receptor autoantibodyPrincipal Investigator
- Principal Investigator
  
  KOHNO Takeyuki
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Setsunan University
エイズウイルスの性交渉感染予防を目的とした経口ワクチンの開発
- Principal Investigator
  
  YAMASHITA Shinji
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Setsunan University
Development of Assay Methods to Measure Salmon Calcitonin with Highly Sensitivity : Determination of the Bioavailability of Nasal Salmon Calcitonin.
- Principal Investigator
  
  KOIDA Masao
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Setsunan University
新しい高感度測定法を用いたサケ・カルシトニンの血中動態解析法の開発Principal Investigator
- Principal Investigator
  
  河野武幸
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Setsunan University
Basic Study on Development of Ultrasensitive Enzyme Immunoassay for Antibodies
- Principal Investigator
  
  ISHIKAWA Eiji
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Miyazaki Medical College

All 2019 2018 2017 2015 2009 2008 2005

All Journal Article Presentation Patent

[Journal Article] 免疫抑制薬フィンゴリモド（FTY720）を用いた免疫寛容誘導2019
- Author(s)
  吉田侑矢、河野武幸
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 71(5) Pages: 508-514
- Data Source
  KAKENHI-PROJECT-17K18263
[Journal Article] Consideration of Preventing Local Venous Pain by Dacarbazine2017
- Author(s)
  大坪達弥，辻琢己，梅山貴生，首藤みほ，米須香那，松本美菜子，吉田侑矢，坂野理絵，友金幹視，藤田敦夫，河野武幸，三上正
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 137 Issue: 3 Pages: 363-369
- DOI
  10.1248/yakushi.16-00222
- NAID
  130005396871
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2017-03-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08117
[Journal Article] ダカルバジンによる血管痛を抑制できる前投薬医薬品2017
- Author(s)
  辻　琢己，大坪　達弥，河野　武幸
- Journal Title
  
  BIO Clinica
  
  Volume: 32 Pages: 62-64
- Data Source
  KAKENHI-PROJECT-15K08117
[Patent] 有機化合物の製造方法およびそれに用いる抗体2005
- Inventor(s)
  上里新一, 長岡康夫, 河野武幸
- Industrial Property Rights Holder
  大阪TLO
- Filing Date
  2005-02-09
- Data Source
  KAKENHI-PROJECT-14655343
[Presentation] Glucose-6-phophate isomerase peptide (GPI325-339) 誘導性関節炎に対するFTY720と病因抗原併用療法の有用性とそのメカニズム - 第七報-: IL-10高産生性T細胞のRNA-seq 解析2019
- Author(s)
  長池新、才本麻矢、下野遥香、吉田侑矢、三上統久、坂野理絵、辻琢己、河野武幸
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K18263
[Presentation] Induction of immune tolerance by combination treatment with fingolimod (FTY720) plus pathogenic antigen in s glicose-6-phosphate isomerase peptide-induced arthritis mouse model: the fifth report2018
- Author(s)
  Yuya Yoshida, Norihisa Mikami, Rie Banno, Takumi Tsuji, Takeyuki Kohno
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K18263
[Presentation] 関節リウマチに効果的に免疫寛容を導入できる治療戦略の探索2018
- Author(s)
  吉田侑矢、三上統久、河野武幸
- Organizer
  第68回日本薬学会近畿支部総会・大会
- Data Source
  KAKENHI-PROJECT-17K18263
[Presentation] Induction of immune tolerance by combination treatment with fingolimod (FTY720) plus pathogenic antigen in a glucose-6-phosphate isomerase peptide-induced arthritis mouse model: the fourth report.2017
- Author(s)
  Yuya Yoshida、Norihisa Mikami、Rie Banno、Takumi Tsuji、Takeyuki Kohno
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K18263
[Presentation] FTY720と病因抗原の併用療法が誘導するTr1様細胞の特性解析2017
- Author(s)
  中西祐亮、才本麻矢、長池新、吉田侑矢、三上統久、坂野理絵、辻琢己、河野武幸
- Organizer
  第67回日本薬学会近畿支部総会・大会
- Data Source
  KAKENHI-PROJECT-17K18263
[Presentation] ダカルバジンによる血管痛は抗ブラジキニン作用で抑制される-ddYマウスを用いた検討-2017
- Author(s)
  松井久明，菊田真穂，大坪達弥，友金幹視，辻琢己，河野武幸
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K08117
[Presentation] ダカルバジン投与時に生じる血管痛の抑制2015
- Author(s)
  大坪達弥、辻琢己、友金幹視、藤田敦夫、魚嶋伸彦、小林裕、河野武幸、三上正
- Organizer
  第13回日本臨床腫瘍学会
- Place of Presentation
  北海道（札幌）
- Year and Date
  2015-07-17
- Data Source
  KAKENHI-PROJECT-15K08117
[Presentation] モノクローナル抗体を反応場としたタキソール合成の試み-抗クキソールモノクローナル抗体の作製2009
- Author(s)
  武本佳樹, 白浜辰弥, 河野武幸, 辻琢己, 盛實祐希, 長岡康夫, 上里新一
- Organizer
  日本薬学会129年会
- Place of Presentation
  京都国際会議場
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-19550114
[Presentation] モノクローナル抗体を反応場としたタキソール合成の試み-抗タキソールモノクローナル抗体の作製2009
- Author(s)
  武本佳樹, 白浜辰弥, 河野武幸, 辻琢己, 盛實祐希, 長岡康夫, 上里新一
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-19550114
[Presentation] アトピー性皮膚炎に対する新規免疫抑制剤FTY720の治療効果 : NC/Ngaマウスを用いた検討2008
- Author(s)
  辻琢己, 菊田裕規, 松下尚弘, 吉田侑矢, 藤多哲朗, 河野武幸
- Organizer
  2008年度日本免疫学会学術集会
- Place of Presentation
  国立京都国際会館(京都)
- Year and Date
  2008-12-01
- Data Source
  KAKENHI-PROJECT-19590166
[Presentation] FTY720は外因性抗原に対する免疫応答を抑制しない2008
- Author(s)
  辻琢己, 吉田侑矢, 藤多哲朗, 河野武幸
- Organizer
  日本薬学会第128年会
- Place of Presentation
  パシフイコ横浜(横浜市)
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-19590166

1. TSUJI Takumi (90454652)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
2. NAGAOKA Yasuo (90243039)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
3. YOSHIDA Yuya (50581435)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
4. YAMASHITA Shinji (00158156)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. UESATO Shinichi (50111969)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. KOIDA Masao (80039651)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. NAKAMUTA Hiromichi (70164275)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. BANNO Rie (90736844)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
9. SAKANE Toshiyasu (50215638)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. FUJITA Tetsuro (40027024)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. ISHIKAWA Eiji (40029939)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. MIKAMI Norihisa (20710388)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
13. MATSUSHITA Naohiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. OHKUBO Satoru

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. MIKAMI Tadashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. OHTSUBO Tatsuya

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results

KOHNO Takeyuki 河野 武幸

河野 武幸 コウノ タケユキ

KOUNO Takeyuki 河野 武幸

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Development of methods for reducing venous pain caused by dacarbazinePrincipal Investigator

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A novel immunomodulator, FTY720, ameliorates spontaneous dermatitis in NC/Nga micePrincipal Investigator

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Development of Mass-Screening Method for the Identification of Patients at Risk of Developing Type 1 Diabetes Mellitus.Principal Investigator

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Development of ultra-sensitive enzyme immunoassay for anti-acetylcholine receptor autoantibodyPrincipal Investigator

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新しい高感度測定法を用いたサケ・カルシトニンの血中動態解析法の開発Principal Investigator

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KOHNO Takeyuki 河野武幸

河野武幸コウノタケユキ

KOUNO Takeyuki 河野武幸