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Harigae Hideo  張替 秀郎

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… Alternative Names

HARIKAE Hiderou  張替 秀郎

HARIGAE Hideo  張替 秀郎

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Researcher Number 50302146
Other IDs
External Links
Affiliation (Current) 2025: 東北大学, 大学病院, 教授
2025: 東北大学, 医学系研究科, 教授
Affiliation (based on the past Project Information) *help 2023 – 2024: 東北大学, 大学病院, 教授
2022 – 2023: 東北大学, 医学系研究科, 教授
2016 – 2020: 東北大学, 医学系研究科, 教授
2014 – 2016: 東北大学, 医学(系)研究科(研究院), 教授
2012: 東北大学, 医学(系)研究科(研究院), 教授 … More
2011 – 2012: 東北大学, 医学系研究科, 教授
2009 – 2010: 東北大学, 大学院・医学系研究科, 教授
2007: Tohoku University, Tohoku University Graduate School of Medicine, 教授
2005 – 2006: Tohoku University, Hospital, Associate Professor, 病院, 講師
2003 – 2006: 東北大学, 病院・講師
2004: 東北大学, 大学病院, 講師
2002 – 2003: 東北大学, 医学部附属病院, 講師
2001 – 2002: 東北大学, 医学部附属病院, 助手
2001: Tohoku Univ. Hospital, Research Associate, 医学部・付属病院, 助手
2001: Tohoku University Hospital, Lecturer, 医学部・附属病院, 講師
1999 – 2001: 東北大学, 医学部・附属病院, 助手
1999: 東北大学, 大学院・医学系研究科, 助手 Less
Review Section/Research Field
Principal Investigator
Hematology / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / Basic Section 54010:Hematology and medical oncology-related / Laboratory medicine / Hematology
Except Principal Investigator
Pathological medical chemistry / Laboratory medicine / Medium-sized Section 48:Biomedical structure and function and related fields / 膠原病・アレルギー・感染症内科学 / 内科学一般 … More / General medical chemistry / Laboratory medicine / Pathological medical chemistry / Obstetrics and gynecology / Biological Sciences Less
Keywords
Principal Investigator
ヘム / heme / 内科 / 造血 / GATA2 / erythropoiesis / 赤血球造血 / 肺血管内皮 / ミトコンドリア / 獲得免疫 … More / T細胞分化 / T細胞初期分化 / 血液内科学 / 鉄芽球性貧血 / 癌 / フローサイトメトリー / アミノレブリン酸 / フローサイトメトリ― / 微小残存病変 / transcriptional regulation / hematopoietic cell differentiation / 遺伝子制御 / 血球分化 / gene regulation / 遺伝子調節 / erythroid differentiation / iron metabolism / ALAS2 / 赤血球型δ-アミノレブリン酸合成酵素 / 合成酵素 / 赤血球型δ-アミノレブリン酸 / X染色体連鎖性鉄芽球性貧血 / 赤血球型б-アミノレブリン酸合成酵素 / 赤血球分化 / 鉄代謝 / ヘム合成 / 赤血球型δアミノレブリン酸合成酵素 / 内科学 … More
Except Principal Investigator
RNA interference / Ku80 / 関節リウマチ / 白血病 / 骨髄異形成症候群 / 遺伝子発現 / 転写因子 / 老化 / 造血幹細胞 / MLR / SLE / ヘム / マクロファージ / siRNA / rheumatoid arthritis / TNF-α / NS1 / aminolevulinate synthase / アミノレブリン酸合成酵素 / anti-DNA antibody / 抗DNA抗体 / 遺伝性鉄芽球性貧血 / スクシニルCoA合成酵素 / レセプター / ヒトパルボウイルスB19 / 赤血球 / 造血管細胞 / 疲弊 / Bach2 / Tリンパ球 / 腫瘍免疫 / 質量分析 / Bach1 / Dendritic cell / Fc receptor / 細胞内侵入 / MDDC / カベオラ / ラフト / 樹状細胞 / heme oxygenase / heme / アミルブリン酸合成酵素 / ヘムオキシゲナーゼ / neutralizing antibody / KU80 / human parvovirus B19 / 低酸素 / P抗原 / T細胞 / 持続感染 / si RNA / ウイルス中和抗体 / TNFα / ヒトパルボウィルスB19 / 中和抗体 / ku80 / Parvovirus B19 / トランスジェニックマウス / 感染受容体 / 間接リウマチ / パルボウイルスB19 / hereditary sideroblastic anemia / succinyl CoA synthethase / RNA干渉法 / lupus nephritis / systemic lupus erythematosus / ループス腎炎 / 全身性エリテマトーデス / genetic tests / multi-drug resistance / MDRI gene / real-time quantitat*ue RFPCR / acute leukemia / hematological tumors / MRPI遺伝子 / MDRI遺伝子 / 薬物耐性 / 定量PCR法 / 薬剤耐性遺伝子 / 遺伝子診断 / 薬剤耐性 / 遺伝子検査 / 多剤耐性 / MDR1遺伝子 / リアルタイム遺伝子定量法 / 急性白血病 / 造血器腫瘍 / Hereditary Sideroblastic Anemia / Succinyl CoA synthethase / 5-aminolevulinate synthase / split hybrid system / スクシニルCoAシンターゼ / スクシニルCoA酵素 / 5-アミノレブリン酸合成酵素 / adult T cell leukemia virus / retrovirus / antinucleic acid antibody / Gene therapy / V遺伝子 / ヒトT細胞白血病ウイルス / VH,VL / 人工単鎖抗体 / 成人型T細胞 / レトロウィルス / 成人型T細胞白血病ウイルス / レトロウイルス / 遺伝子治療 / 抗核酸抗体 / 免疫抑制マウス / 卵子バンク / 生殖補助技術 / 卵巣凍結 / 卵子 / Oncofertility / フローサイトメトリー / 酸化ストレス / PCR / 微少残存病変 / 腫瘍マーカー / 微量残存病変 / ELISA / スタニオカルシン Less
  • Research Projects

    (26 results)
  • Research Products

    (58 results)
  • Co-Researchers

    (29 People)
  •  ヘム合成に着目した免疫細胞分化制御機構の解明とその破綻に伴う疾患の克服Principal Investigator

    • Principal Investigator
      張替 秀郎
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Tohoku University
  •  転写因子GATA2に着目した造血と肺血管内皮の連関解析Principal Investigator

    • Principal Investigator
      張替 秀郎
    • Project Period (FY)
      2024 – 2025
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
    • Research Institution
      Tohoku University
  •  The Roles of Transcription Factor GATA2 in T Cell Development by Epigenetic MemoryPrincipal Investigator

    • Principal Investigator
      Harigae Hideo
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
    • Research Institution
      Tohoku University
  •  Age-related alterations of hematopoietic stem and progenitor cells due to failure of Bach transcription factors

    • Principal Investigator
      IGARASHI Kazuhiko
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 48:Biomedical structure and function and related fields
    • Research Institution
      Tohoku University
  •  Elucidation of epigenetic regulation of erythropoiesis and translation to therapeutic strategy

    • Principal Investigator
      IGARASHI Kazuhiko
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Challenging Research (Pioneering)
    • Review Section
      Medium-sized Section 48:Biomedical structure and function and related fields
    • Research Institution
      Tohoku University
  •  International collaborative effort to study of pathophysiology and development of novel therapy of congenital sideroblastic anemiaPrincipal Investigator

    • Principal Investigator
      Harigae Hideo
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Tohoku University
  •  Development of a new strategy for tumor immunity activation

    • Principal Investigator
      IGARASHI Kazuhiko
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Tohoku University
  •  The photodynamic detection of MRD of multiple myeloma by flowcytometoryPrincipal Investigator

    • Principal Investigator
      HARIGAE HIDEO
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Laboratory medicine
    • Research Institution
      Tohoku University
  •  Regulation of erythropoiesis and macrophages by the heme signal

    • Principal Investigator
      IGARASHI Kazuhiko
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      General medical chemistry
    • Research Institution
      Tohoku University
  •  Generation and analysis of in vitro, in vivo model of sideroblastic anemiaPrincipal Investigator

    • Principal Investigator
      Harigae Hideo
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Tohoku University
  •  Examination of the behavior of the human leukemia cells in immunodeficient mice: For the safety improvement of the ovarian bank

    • Principal Investigator
      TERADA Yukihiro
    • Project Period (FY)
      2009 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Akita University
      Tohoku University
  •  Identification and functional analysis of erythroid-specific genes regulated by hemePrincipal Investigator

    • Principal Investigator
      HARIGAE Hideo
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Tohoku University
  •  Multiple mechanisms for the regulation of heme biosynthesis and catabolism.

    • Principal Investigator
      FURUYAMA Kazumichi
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Tohoku University
  •  Analysis of new biomarker for evaluation of SLE activity with autoantibody penetration to cells

    • Principal Investigator
      ISHII Tomonori
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory medicine
    • Research Institution
      Tohoku University
  •  Mechanism for human parvovirus B19-induced rheumatoid arthjritis

    • Principal Investigator
      SASAKI Takeshi
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      TOHOKU UNIVERSITY
  •  Regulation of erythropoiesis mediated by hemePrincipal Investigator

    • Principal Investigator
      HARIGAE Hideo
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      TOHOKU UNIVERSITY
  •  関節リウマチ発症におけるヒトパルボウイルスB19に関する研究

    • Principal Investigator
      佐々木 毅
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University
  •  The disruption of protein-protein interaction in mitochondria results in sideroblastic anemia.

    • Principal Investigator
      FURUYAMA Kazumichi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Tohoku University
  •  Pathogenic role of virus gene that was detected in patients with rheumatoid arthritis

    • Principal Investigator
      MUNAKATA Yasuhiko
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      TOHOKU UNIVERSITY
  •  新規酸化ストレス測定系の確立と臨床応用

    • Principal Investigator
      賀来 満夫
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Laboratory medicine
    • Research Institution
      Tohoku University
  •  Etiological agents responsible for systemic lupus erythrmatosus

    • Principal Investigator
      SASAKI Takeshi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      内科学一般
    • Research Institution
      Tohoku University
  •  Antinucleic aid antibody gene therapy for rheumatoid Arthritis and adult T cell Leukemia

    • Principal Investigator
      SASAKI Takeshi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      内科学一般
    • Research Institution
      Tohoku University
  •  Research for the relationship of hereditary sideroblastic anemia with enzyme complex formation in mitochondria

    • Principal Investigator
      FURUYAMA Kazumichi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Tohoku University
  •  Development of genetic diagmosis for drug resistance in cancer

    • Principal Investigator
      FUNATO Tadao
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory medicine
    • Research Institution
      Tohoku University
  •  腫瘍マーカーとしてのカルシウム調節ホルモン・スタニオカルシン

    • Principal Investigator
      SASAKI Takeshi
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Laboratory medicine
    • Research Institution
      Tohoku University
  •  Identification of the causative gene for inherited sideroblastic anemia and analysis of sideroblastis induced in vitroPrincipal Investigator

    • Principal Investigator
      HARIGAE Hideo
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Tohoku University

All 2023 2019 2018 2017 2016 2015 2007 2006 2003 Other

All Journal Article Presentation Patent

  • [Journal Article] Study of pathophysiology and molecular characterization of congenital anemia in India using targeted next-generation sequencing approach2019

    • Author(s)
      Kedar PS, Harigae H, Ito E, Muramatsu H, Kojima S, Okuno Y, Fujiwara T, Dongerdiye R, Warang PP, Madkaikar MR
    • Journal Title

      Int J Hematol

      Volume: 60 Issue: 5 Pages: 408-416

    • DOI

      10.1007/s12185-019-02716-9

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08314, KAKENHI-PROJECT-18H04039, KAKENHI-PROJECT-17H04668
  • [Journal Article] Molecular pathophysiology and genetic mutations in congenital sideroblastic anemia2019

    • Author(s)
      Fujiwara T, Harigae H
    • Journal Title

      Free Radic Biol Med

      Volume: 133 Pages: 179-185

    • DOI

      10.1016/j.freeradbiomed.2018.08.008

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K08314, KAKENHI-PROJECT-17H04668
  • [Journal Article] Generation and Molecular Characterization of Human Ring Sideroblasts: a Key Role of Ferrous Iron in Terminal Erythroid Differentiation and Ring Sideroblast Formation.2019

    • Author(s)
      Saito K, Fujiwara T, Hatta S, Morita M, Ono K, Suzuki C, Fukuhara N, Onishi Y, Nakamura Y, Kawamata S, Shimizu R, Yamamoto M, Harigae H.
    • Journal Title

      Mol Cell Biol.

      Volume: 39 Issue: 7

    • DOI

      10.1128/mcb.00387-18

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H02507, KAKENHI-PROJECT-18K08314, KAKENHI-PROJECT-17H04668, KAKENHI-PROJECT-19H03555
  • [Journal Article] Iron as Soul of Life on Earth Revisited: From Chemical Reaction, Ferroptosis to Therapeutics2019

    • Author(s)
      Harigae Hideo、Hino Keisuke、Toyokuni Shinya
    • Journal Title

      Free Radical Biology and Medicine

      Volume: 133 Pages: 1-2

    • DOI

      10.1016/j.freeradbiomed.2019.01.042

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04064, KAKENHI-PROJECT-17H04668
  • [Journal Article] Infection perturbs Bach2- and Bach1-dependent erythroid lineage chioce to cause anemia2018

    • Author(s)
      Kato H, Itoh-Nakadai A, Matsumoto M, Ishii Y, Watanabe-Matsui M, Ikeda M, Ebina-Shibuya R, Sato Y, Kobayashi M, Nishizawa H, Suzuki K, Muto A, Fujiwara T, Nannya Y, Cazzola M, Ogawa S, Harigae H, Igarashi K
    • Journal Title

      Nat Immunol

      Volume: 19 Issue: 10 Pages: 496-497

    • DOI

      10.1038/s41590-018-0202-3

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08314, KAKENHI-PROJECT-26221308, KAKENHI-PROJECT-18H04021, KAKENHI-PROJECT-16K07108, KAKENHI-PROJECT-16J40189, KAKENHI-PROJECT-16K08572
  • [Journal Article] Successful treatment of X-linked sideroblastic anemia with <i>ALAS2</i> R452H mutation using vitamin B<sub>6</sub>2018

    • Author(s)
      Kawakami T, Nakazawa H, Kawakami F, Matsuzawa S, Sudo Y, Sakai H, Nishina S, Senoo N, Senoo Y, Komatsu M, Umemura T, Yamaguchi T, Kosho T, Fujiwara T, Harigae H, Ishida F.
    • Journal Title

      Rinsho Ketsueki

      Volume: 59 Issue: 4 Pages: 401-406

    • DOI

      10.11406/rinketsu.59.401

    • NAID

      130006733285

    • ISSN
      0485-1439, 1882-0824
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H04668
  • [Journal Article] Five-aminolevulinic acid: New Approach for Congenital Sideroblastic Anemia2018

    • Author(s)
      Ishida H, Imamura T, Morimoto A, Fujiwara T, Harigae H
    • Journal Title

      Pediatr Int

      Volume: 60 Issue: 5 Pages: 496-497

    • DOI

      10.1111/ped.13558

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K08314, KAKENHI-PROJECT-17H04668
  • [Journal Article] A defined culture method enabling the establishment of ring sideroblasts from induced pluripotent cells of X-linked sideroblastic anemia.2018

    • Author(s)
      1.Hatta S, Fujiwara T, Yamamoto T, Saito K, Kamata M, Tamai Y, Kawamata S, Harigae H.
    • Journal Title

      Haematologica.

      Volume: - Issue: 5 Pages: 188-191

    • DOI

      10.3324/haematol.2017.179770

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04668, KAKENHI-PROJECT-15K09447, KAKENHI-PROJECT-16K19564, KAKENHI-PROJECT-18K08314
  • [Journal Article] Forced FOG1 expression in erythroleukemia cells: Induction of erythroid genes and repression of myelo-lymphoid transcription factor PU.1.2017

    • Author(s)
      Fujiwara T, Sasaki K, Saito K, Hatta S, Ichikawa S, Kobayashi M, Okitsu Y, Fukuhara N, Onishi Y, Harigae H.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 485 Issue: 2 Pages: 380-387

    • DOI

      10.1016/j.bbrc.2017.02.068

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26293225, KAKENHI-PROJECT-16K19564, KAKENHI-PROJECT-16K09819, KAKENHI-PROJECT-15K09447
  • [Journal Article] Dynamics of absorption, metabolism, and excretion of 5-aminolevulinic acid in human intestinal Caco-2 cells.2017

    • Author(s)
      Saito K, Fujiwara T, Ota U, Hatta S, Ichikawa S, Kobayashi M, Okitsu Y, Fukuhara N, Onishi Y, Ishizuka M, Tanaka T, Harigae H
    • Journal Title

      Biochemistry and Biophysics Reports

      Volume: 11 Pages: 105-111

    • DOI

      10.1016/j.bbrep.2017.07.006

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09819, KAKENHI-PROJECT-17K16176, KAKENHI-PROJECT-17H04668, KAKENHI-PROJECT-15K09447, KAKENHI-PROJECT-16K15324, KAKENHI-PROJECT-16K19564
  • [Journal Article] Impact of TET2 deficiency on iron metabolism in erythroblasts.2017

    • Author(s)
      Inokura K, Fujiwara T, Saito K, Iino T, Hatta S, Okitsu Y, Fukuhara N, Onishi Y, Ishizawa K, Shimoda K, Harigae H
    • Journal Title

      Exp Hematol.

      Volume: - Pages: 56-67

    • DOI

      10.1016/j.exphem.2017.01.002

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26293225, KAKENHI-PROJECT-15K09447, KAKENHI-PROJECT-16K09819, KAKENHI-PROJECT-16K19564, KAKENHI-PROJECT-17H04210
  • [Journal Article] Clinical utility of next-generation sequencing for inherited bone marrow failure syndromes.2017

    • Author(s)
      Muramatsu H, Okuno Y, Yoshida K, Shiraishi Y, Doisaki S, Narita A, Sakaguchi H, Kawashima N, Wang X, Xu Y, Chiba K, Tanaka H, Hama A, Sanada M, Takahashi Y, Kanno H, Yamaguchi H, Ohga S, Manabe A, Harigae H, Kunishima S, Ishii E, Kobayashi M, Koike K, Watanabe K, Ito E, Takata M, Yabe M, Ogawa S, Miyano S, Kojima S.
    • Journal Title

      Genet Med.

      Volume: - Issue: 7 Pages: 796-802

    • DOI

      10.1038/gim.2016.197

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-15H05909, KAKENHI-PROJECT-26221308, KAKENHI-PROJECT-15H01738, KAKENHI-PROJECT-26253061, KAKENHI-PROJECT-26293225, KAKENHI-PROJECT-15K09647, KAKENHI-PROJECT-16K09832, KAKENHI-PROJECT-16K10041, KAKENHI-PROJECT-15H04874
  • [Journal Article] Iron-heme-Bach1 axis is involved in erythroblast adaptation to iron deficiency.2017

    • Author(s)
      Kobayashi M, Kato H, Hada H, Itoh-Nakadai A, Fujiwara T, Muto A, Inoguchi Y, Ichiyanagi K, Hojo W, Tomosugi N, Sasaki H, Harigae H, Igarashi K.
    • Journal Title

      Haematologica

      Volume: 102 Issue: 3 Pages: 454-465

    • DOI

      10.3324/haematol.2016.151043

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26293225, KAKENHI-PROJECT-16K08572, KAKENHI-PROJECT-15H02506
  • [Journal Article] A novel heterozygous ALAS2 mutation in a female with macrocytic sideroblastic anemia resembling myelodysplastic syndrome with ring sideroblasts: a case report and literature review2017

    • Author(s)
      Fujiwara T, Fukuhara N, Ichikawa S, Kobayashi M, Okitsu Y, Onishi Y, Furuyama K, Harigae H
    • Journal Title

      Annals of Hematology

      Volume: 96(11) Issue: 11 Pages: 1955-1957

    • DOI

      10.1007/s00277-017-3106-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09819, KAKENHI-PROJECT-17K08640, KAKENHI-PROJECT-17K16176, KAKENHI-PROJECT-17H04668, KAKENHI-PROJECT-15K09447
  • [Journal Article] Identification of a novel putative mitochondrial protein FAM210B associated with erythroid differentiation.2016

    • Author(s)
      Kondo A, Fujiwara T, Okitsu Y, Fukuhara N, Onishi Y, Nakamura Y, Sawada K, Harigae H.
    • Journal Title

      Int J Hematol.

      Volume: 103 Issue: 4 Pages: 387-395

    • DOI

      10.1007/s12185-016-1968-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26293225, KAKENHI-PROJECT-15K09447, KAKENHI-PROJECT-16K09819
  • [Journal Article] Expression analyses and transcriptional regulation of mouse nucleolar spindle-associated protein gene in erythroid cells: essential role of NF-Y2006

    • Author(s)
      Fujiwara T, Harigae H, Takahashi S, OkitsuY, Yokoyama H Yamada FM, Ishizawa K, Kameoka J, Kaku M, Sasaki T
    • Journal Title

      British Journal of Haematology. 135

      Pages: 583-590

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591038
  • [Journal Article] Functional Analyses and Transcriptional Regulation of Mouse Nuclear Spindle-Associated Protein (NuSAP) Gene in Erythroid Cells : Essential Role of NF-Y2006

    • Author(s)
      Fujiwara T, Harigae H, Takahashi S, OkitsuY, Yokoyama H, Yamada FM, Ishizawa K, Kameoka J, Kaku M, Sasaki T
    • Journal Title

      British Journal of Haematology. 135

    • Data Source
      KAKENHI-PROJECT-18591038
  • [Journal Article] Expression analyses and transcriptional regulation of mouse nucleolar spindle-associated protein gene in erythroid cells: essential role of NF-Y2006

    • Author(s)
      Fujiwara T, Harigae H, Takahashi S, Okitsu Y, Yokoyama H Yamada FM, Ishizawa K, Kameoka J, Kaku M, Sasaki T.
    • Journal Title

      British Journal of Haematology 135

      Pages: 538-590

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591038
  • [Journal Article] Regulation of YB-1 gene expression by GATA transcription factors.2003

    • Author(s)
      H.Yokoyama, H.Harigae, S.Takahashi, K.Furuyama, M.Kaku, M.Yamamoto, T.Sasaki
    • Journal Title

      Biochem Biophys Res Commun. 303

      Pages: 140-145

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590266
  • [Journal Article] Aberrant iron accumulation and oxidized status of erythroid-specific delta-aminolevulinate synthase(ALAS2)-deficient definitive erythroblasts.2003

    • Author(s)
      H.Harigae, O.Nakajima, N.Suwabe, H.Yokoyama, K.Furuyama 他
    • Journal Title

      Blood 101

      Pages: 1188-1193

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590266
  • [Journal Article] Late-onset X-linked sideroblastic anemia following hemodialysis.2003

    • Author(s)
      K.Furuyama, H.Harigae, C.Kinoshita, T.Shimada, K.Miyaoka, C.Kanda, Y.Maruyama, S.Shibahara, S.Sassa
    • Journal Title

      Blood 101

      Pages: 4623-4624

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590266
  • [Journal Article] Aberrant iron accumulation and oxidized status of erythroid-specific delta-aminolevulinate synthase (ALAS2)-deficient definitive erythroblasts.2003

    • Author(s)
      H.Harigae, O.Nakajima, N.Suwabe, H.Yokoyama, K.Furuyama, T.Sasaki, M.Kaku, M.Yamamoto, S.Sassa
    • Journal Title

      Blood 101

      Pages: 1188-1193

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590266
  • [Journal Article] Regulation of YB-1 gene expression by GATA transcription factors.2003

    • Author(s)
      H.Yokoyama, H.Harigae, S.Takahashi, K.Furuyama, 他
    • Journal Title

      Biochem Biophys Res Commun 303

      Pages: 140-145

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590266
  • [Patent] 国際特許2019

    • Inventor(s)
      五十嵐和彦、加藤浩貴、石井悠翔、グエン チ ロン、張替秀郎
    • Industrial Property Rights Holder
      東北大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Overseas
    • Data Source
      KAKENHI-PROJECT-20K20382
  • [Patent] 特許権2019

    • Inventor(s)
      五十嵐和彦、加藤浩貴、石井悠翔、グエン チ ロン、張替秀郎
    • Industrial Property Rights Holder
      東北大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Overseas
    • Data Source
      KAKENHI-PROJECT-20K20382
  • [Presentation] Transcription Factor GATA2 Is Inevitable for the Survival and Proper Differentiation of Thymic Multipotent Progenitor Cells By Gene Expression Orchestration2023

    • Author(s)
      Sayaka Sano, Hiroki Kato, Yan Yan, Eijiro Furukawa, Daigo Michimata, Yuya Tanaka, Kazuki Sakurai, Koichi Onodera, Satoshi Ichikawa, Noriko Fukuhara, Yasushi Onishi, Hisayuki Yokoyama, Tohru Fujiwara, Hideo Harigae.
    • Organizer
      第65回米国血液学会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19537
  • [Presentation] Gene regulatory network for hematopoietic stem and progenitor differentiation2019

    • Author(s)
      Igarashi K, Kato H, Harigae H.
    • Organizer
      International Symposium on Epigenome
    • Invited
    • Data Source
      KAKENHI-PROJECT-18H04021
  • [Presentation] CRISPR/Cas9を用いたALAS2ミスセンス変異導入によるX連鎖性鉄芽球性貧血のモデル細胞2019

    • Author(s)
      小野浩弥、高橋昇之、藤原亨、細川奈津子、齋藤慧、鈴木千恵、小野寺晃一、市川聡、福原規子、大西康、張替秀郎
    • Organizer
      第43回日本鉄バイオサイエンス学会学術集会
    • Data Source
      KAKENHI-PROJECT-17H04668
  • [Presentation] Role of mitochondrial membrane protein FAM210B during erythroid differentiation2019

    • Author(s)
      Chie Suzuki ,Toru Fujiwara ,Kei Saito,Hiroki Shima ,Koya Ono,Koichi Onodera,Satoshi Ichikawa ,Noriko Fukuhara ,Yasushi Onishi ,Yukio Nakamura,Hideo Harigae
    • Organizer
      第81回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-17H04668
  • [Presentation] Proteomic Analysis of Mitochondrial Membrane Protein FAM210B in Erythroid Cells2019

    • Author(s)
      Chie Suzuki , Tohru Fujiwara, Hiroki Shima , Koya Ono, Kei Saito , Noriko Fukuhara,Yasushi Onishi, Hisayuki Yokoyama, Shinichi Fujimaki , Yukio Nakamura, Hideo Harigae,
    • Organizer
      61 st ASH Annual Meeting & Exposition (第61回アメリカ血液学会)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04668
  • [Presentation] Establishment of cellular model of X-linked sideroblastic anemia using homology-directed CRISPR/Cas92019

    • Author(s)
      Koya Ono,Noriyuki Takahashi ,Toru Fujiwara,Kei Saito ,Koichi Onodera ,Satoshi Ichikawa ,Noriko Fukuhara ,Yasushi Onishi ,Hideo Harigae
    • Organizer
      第81回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-17H04668
  • [Presentation] HRM解析による簡易SF3B1遺伝子変異スクリーニング法の確立2019

    • Author(s)
      鈴木千恵、藤原亨、平泉敦子、藤巻慎一、張替秀郎
    • Organizer
      第43回日本鉄バイオサイエンス学会学術集会
    • Data Source
      KAKENHI-PROJECT-17H04668
  • [Presentation] 鉄代謝と貧血2018

    • Author(s)
      張替秀郎
    • Organizer
      日本内科学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04668
  • [Presentation] X連鎖性鉄芽球性貧血患者の疾患特異的iPS細胞の樹立2018

    • Author(s)
      藤原亨、八田俊介、斎藤慧、福原規子、大西康、田中徹、川真田伸、張替秀郎
    • Organizer
      第42回日本鉄バイオサイエンス学会
    • Data Source
      KAKENHI-PROJECT-17H04668
  • [Presentation] Generation and Molecular Characterization of Human Ring Sideroblasts2018

    • Author(s)
      Saito K, Fujiwara T, Hatta S, Suzuki C, Fukuhara N, Onishi Y, Nakamura Y, Harigae H
    • Organizer
      60th ASH Annual Meeting & Exposition
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04668
  • [Presentation] Characterization of in vitro model of X-linked sideroblastic anemia2018

    • Author(s)
      Saito K, Fujiwara T, Hatta S, Onodera K, Ichikawa S, Fukuhara N, Onishi Y, Nakamura Y, Harigae H
    • Organizer
      第80回日本血液学会
    • Data Source
      KAKENHI-PROJECT-17H04668
  • [Presentation] X連鎖性鉄芽球性貧血モデルの樹立および特性解析2018

    • Author(s)
      斎藤慧、藤原亨、八田俊介、福原規子、大西康、中村幸夫、田中徹、張替秀郎
    • Organizer
      第42回日本鉄バイオサイエンス学会
    • Data Source
      KAKENHI-PROJECT-17H04668
  • [Presentation] A novel therapeutic approach for congenital sideroblastic anemia using 5-aminolevulinic acid.2017

    • Author(s)
      Ishida H, Fujiki A. Imamura T, Morimoto A, Ota U, Takahashi K, Ishizawa M, Fujiwara T, Harigae H
    • Organizer
      日本血液学会
    • Data Source
      KAKENHI-PROJECT-17H04668
  • [Presentation] Generation of induced pluripotent stem cell-derived erythroblasts of X-linked sideroblastic anemia2017

    • Author(s)
      Hatta S, Fujiwara T, Yamamoto T, Saito K, Kamata M, Tamai Y, Kawamata S, Harigae H
    • Organizer
      日本血液学会
    • Data Source
      KAKENHI-PROJECT-17H04668
  • [Presentation] ALAS2遺伝子変異を認めた大球性鉄芽球性貧血の一例2017

    • Author(s)
      藤原亨、福原規子、猪俣美津恵、大西康、古山和道、張替秀郎
    • Organizer
      日本鉄バイオサイエンス学会
    • Data Source
      KAKENHI-PROJECT-17H04668
  • [Presentation] 鉄芽球性貧血の病態2017

    • Author(s)
      張替秀郎
    • Organizer
      臨床ストレス応答学会
    • Data Source
      KAKENHI-PROJECT-17H04668
  • [Presentation] Establishment of in vivo and in vitro model of x-linked sideroblastic anemia by CRISPER/Cas92017

    • Author(s)
      Saito K, Fujiwara T, Morita M, Hatta S, Fukuhara N, Onishi Y, Nakamura n, Shimizu R, Harigae H
    • Organizer
      日本血液学会
    • Data Source
      KAKENHI-PROJECT-17H04668
  • [Presentation] Establishment of in vitro model of X-linked sideroblastic anemia2017

    • Author(s)
      Saito K, Fujiwara T, Hatta S, Oktsu Y, Fukuhara N, Onishi Y, Nakamura Y, Harigae H
    • Organizer
      ASH Annual Meeting & Exposition
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04668
  • [Presentation] 鉄と赤血球造血2017

    • Author(s)
      張替秀郎
    • Organizer
      日本微量元素学会
    • Data Source
      KAKENHI-PROJECT-17H04668
  • [Presentation] Establishment of in vivo and in vitro model of X-linked sideroblastic anemia2017

    • Author(s)
      Saito K, Fujiwara T, Morita M, Hatta S, Fukuhara N, Onishi Y, Nakamura Y, Shimizu R, Harigae H
    • Organizer
      Congress of European Hematology Society
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04668
  • [Presentation] Clinical and genetic characteristics of sideroblastic anemia2016

    • Author(s)
      張替秀郎
    • Organizer
      the 14th China National Congress of Hematology
    • Place of Presentation
      suzho jinji lake international convention center 上海・中国
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293225
  • [Presentation] Generation of Induced Pluripotent Stem Cell-Derived Erythroblasts from a Patient with X-Linked Sideroblastic Anemia2016

    • Author(s)
      Shunsuke Hatta,Tohru Fujiwara, Takako Yamamoto, Mayumi Kamata, Yoshiko Tamai, Yukio Nakamura, Shin Kawamata, Hideo Harigae
    • Organizer
      58th Annual Meeting of American Sciety of Hematology
    • Place of Presentation
      SanDiego convention center サンディエゴ・米国
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293225
  • [Presentation] Impact of TET2 on iron metabolism in erythroblasts:A potential link to ring sidero formation2016

    • Author(s)
      斎藤慧、猪倉恭子、藤原亨、八田俊介、沖津庸子、福原規子、大西康、石澤賢一、下田和哉、張替秀郎
    • Organizer
      日本血液学会
    • Place of Presentation
      パシフィコ横浜・横浜市
    • Data Source
      KAKENHI-PROJECT-26293225
  • [Presentation] Identification of a novel mitochondorial protein FAM210B associated with erythroid differentiation2016

    • Author(s)
      近藤愛子、藤原亨、沖津庸子、福原規子、大西康、中村幸夫、澤田賢一、張替秀郎
    • Organizer
      日本血液学会
    • Place of Presentation
      パシフィコ横浜・横浜市
    • Data Source
      KAKENHI-PROJECT-26293225
  • [Presentation] 腸管上皮細胞モデルにおけるALAの代謝2016

    • Author(s)
      斎藤慧、藤原亨、田中徹、張替秀郎
    • Organizer
      日本鉄バイオサイエンス学会
    • Place of Presentation
      名古屋大学豊田講堂・名古屋市
    • Data Source
      KAKENHI-PROJECT-26293225
  • [Presentation] 遺伝性鉄芽球性貧血の疫学と分子病態2015

    • Author(s)
      藤原亨、張替秀郎
    • Organizer
      第39回日本鉄バイオサイエンス学会学術集会
    • Place of Presentation
      岡山コンベンションセンター(岡山市)
    • Year and Date
      2015-08-29
    • Invited
    • Data Source
      KAKENHI-PROJECT-26293225
  • [Presentation] Analyses of heme-regulated genes during erythroid differentiation2007

    • Author(s)
      Fujiwara T, Okitsu Y, Ikura T, Takahashi S, Furuyama K, Igarashi K, Yamamoto M, Sassa S, Harigae H.
    • Organizer
      The 49th annual meeting of American Society of Hematology
    • Year and Date
      2007-12-09
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591038
  • [Presentation] Analyses of Heme-regulated genes during erythroid differentiation.2007

    • Author(s)
      Fujiwara T, Harigae H, 他5名
    • Organizer
      アメリカ血液学会
    • Place of Presentation
      米国 アトランタ市
    • Year and Date
      2007-12-09
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18591038
  • [Presentation] Impact of TET2 deficiency on iron metabolism in erythropoiesis:a potential link to ring sideroblast formation

    • Author(s)
      Inokura K, Fujiwara T, Okitsu Y, Fukuhara N, Onishi Y, Ishizawa K, Shimoda K, Harigae H
    • Organizer
      第56回アメリカ血液学会
    • Place of Presentation
      サンフランシスコ(米国)
    • Year and Date
      2014-12-06 – 2014-12-09
    • Data Source
      KAKENHI-PROJECT-26293225
  • [Presentation] TET2遺伝子の鉄芽球性貧血発症への関与

    • Author(s)
      猪倉恭子、藤原亨、下田和哉、張替秀郎
    • Organizer
      第38回日本鉄バイオサイエンス学会学術集会
    • Place of Presentation
      仙台国際センター(仙台市)
    • Year and Date
      2014-09-06 – 2014-09-07
    • Data Source
      KAKENHI-PROJECT-26293225
  • [Presentation] Exploring potential usefulness of 5-aminolevulinic acid for X-linked sideroblastic anemia

    • Author(s)
      Fujiwara T, Okamoto K, Niikuni R, Takahashi K, Okitsu Y, Fukuhara N, Onishi Y, Ishizawa K, Ichinohasama R, Nakamura Y, Nakajima M, Tanaka T, Harigae H
    • Organizer
      第56回アメリカ血液学会
    • Place of Presentation
      サンフランシスコ(米国)
    • Year and Date
      2014-12-06 – 2014-12-09
    • Data Source
      KAKENHI-PROJECT-26293225
  • [Presentation] Exploring the potential usefulness of 5-aminolevulinic acid (ALA) for sideroblastic anemia

    • Author(s)
      Nikuni R, Fujiwara T, Okitsu Y, Fukuhara N, Onishi Y, Ishizawa K, Ichinohasama R, Tanaka T, Harigae H
    • Organizer
      第76回日本血液学会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2014-10-31 – 2014-11-02
    • Data Source
      KAKENHI-PROJECT-26293225
  • [Presentation] 鉄芽球性貧血に対するALAの有用性の基礎的検討

    • Author(s)
      藤原亨、新國僚祐、田中徹、張替秀郎
    • Organizer
      第38回日本鉄バイオサイエンス学会学術集会
    • Place of Presentation
      仙台国際センター(仙台市)
    • Year and Date
      2014-09-06 – 2014-09-07
    • Data Source
      KAKENHI-PROJECT-26293225
  • 1.  SASAKI Takeshi (50110656)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 2.  MUNAKATA Yasuhiko (20271950)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 3.  KAMEOKA Junichi (30261621)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 4.  FURUYAMA Kazumichi (80280874)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 5 results
  • 5.  IGARASHI Kazuhiko (00250738)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 1 results
  • 6.  加藤 浩貴 (50801677)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 7.  FUNATO Tadao (70165455)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  ISHII Tomonori (10282138)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  TERADA Yukihiro (10260431)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  KUMAGAI Jin (60333936)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  KAWAMATA Shin (00360842)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 12.  FUJIWARA Tohru (60333796)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 18 results
  • 13.  KITAGAWA Yoshichika (10006752)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  ISHII Keiko (00291253)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  SHIBAHARA Shigeki (70206142)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  MATSUI Miki (00455784)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  SAIGUSA Daisuke (90545237)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  賀来 満夫 (40224357)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  八重樫 伸生 (00241597)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  高橋 藍子 (30436125)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  鍋島 寛志 (90547415)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  長谷川 久隆 (20455835)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  梨井 康 (60321890)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  OKITSU Yoko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 25.  SUZUKI Mikiko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 26.  山本 雅之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 27.  小川 誠司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 28.  江藤 浩之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  豊國 伸哉
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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