Mizutani Kiyohito 水谷清人

… Alternative Names

MIZUTANI Kiyohito 水谷清人

Less

Researcher Number	50559177
Other IDs
Affiliation (Current)	2025: 徳島大学, 先端酵素学研究所, 教授
Affiliation (based on the past Project Information) *help	2015 – 2016: 神戸大学, 医学研究科, 特命講師 2013 – 2016: 神戸大学, 医学(系)研究科(研究院), 講師 2014: 神戸大学, 大学院医学研究科, 特命講師 2012 – 2013: 神戸大学, 医学(系)研究科(研究院), 特命助教 2011 – 2012: 神戸大学, 医学(系)研究科(研究院), 助教 2009 – 2010: 神戸大学, 医学研究科, 助教
Review Section/Research Field	Principal Investigator General medical chemistry Except Principal Investigator Functional biochemistry
Keywords	Principal Investigator Necl / ネクチン様分子 / ErbB / 細胞内シグナル伝達 / 血管内皮細胞 / PTPN13 / ErbB3 / CADM4 / Necl-4 / インテグリン / ヘミデスモソーム … More Except Principal Investigator … More アファディン / ネクチン / 異種細胞間接着 / 細胞情報伝達機構 / 細胞膜受容体 / 細胞シグナル伝達機構 / 細胞接着・運動 / 神経シナプス / 上皮細胞 / 神経突起 / 肺腺がん / ネクチン様分子-5 / デスモソーム / アドヘレンスジャンクション / ネクチン様分子 / タイトジャンクション / アドへレンスジャンクション Less

Roles and modes of action of nectins in heterotypic cell-cell adhesions
- Principal Investigator
  
  Takai Yoshimi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kobe University
Regulation by Nectin-like molecules of ErbB family receptor signalingPrincipal Investigator
- Principal Investigator
  
  Mizutani Kiyohito
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
Regulation by Nectin-like molecules of hemidesmosome disassembly and reorganizationPrincipal Investigator
- Principal Investigator
  
  MIZUTANI Kiyohito
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
Roles of Cell Adhesion and Signaling in Cell Morphogenesis
- Principal Investigator
  
  TAKAI YOSHIMI
- Project Period (FY)
  2009 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kobe University

All 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation Patent

[Journal Article] Nectin-4 co-stimulates the prolactin receptor by interacting with SOCS1 and inhibiting its activity on the JAK2-STAT5a signaling pathway.2017
- Author(s)
  Maruoka, M., Kedashiro, S., Ueda, Y., Mizutani, K., and Takai, Y.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 292 Issue: 17 Pages: 6895-6909
- DOI
  10.1074/jbc.m116.769091
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-26114007, KAKENHI-PROJECT-26251013, KAKENHI-PROJECT-16K19035
[Journal Article] A Novel Nectin-mediated Cell Adhesion Apparatus Which Is Implicated in Prolactin Receptor Signaling for Mammary Gland Development2016
- Author(s)
  Kitayama M, Mizutani K, Maruoka M, Mandai K, Sakakibara S, Ueda Y, Komori T, Shimono Y, Takai Y
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 291 Issue: 11 Pages: 5817-5831
- DOI
  10.1074/jbc.m115.685917
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K14381, KAKENHI-PLANNED-26114007, KAKENHI-PROJECT-26251013, KAKENHI-PROJECT-16K19035, KAKENHI-PROJECT-16K20411, KAKENHI-PROJECT-26860190
[Journal Article] Nectin spot: a novel type of nectin-mediated cell adhesion apparatus.2016
- Author(s)
  Mizutani, K., and Takai, Y.
- Journal Title
  
  Biochemical Journal
  
  Volume: 473 Issue: 18 Pages: 2691-2715
- DOI
  10.1042/bcj20160235
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-26114007, KAKENHI-PROJECT-26251013
[Journal Article] Downregulation of CXCR4 in Metastasized Breast Cancer Cells and Implication in Their Dormancy2015
- Author(s)
  Nobutani K, Shimono Y, Mizutani K, Ueda Y, Suzuki T, Kitayama M, Minami A, Momose K, Miyawaki K, Akashi K, Azuma T, Takai Y
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 6 Pages: e0130032-e0130032
- DOI
  10.1371/journal.pone.0130032
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14381, KAKENHI-PLANNED-26114007, KAKENHI-PROJECT-26251013, KAKENHI-PROJECT-26860190
[Journal Article] The cell adhesion molecule necl-4/cadm4 serves as a nobel regulator for contact inhibition of cell movement and proliferation.2015
- Author(s)
  Yamana S, Tokiyama A, Mizutani K, Hirata K, Takai Y, Rikitake Y.
- Journal Title
  
  PloS One.
  
  Volume: 10 Issue: 4 Pages: e0124259-e0124259
- DOI
  10.1371/journal.pone.0124259
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21227005, KAKENHI-PROJECT-24790284, KAKENHI-PLANNED-26114007, KAKENHI-PROJECT-26251013, KAKENHI-PROJECT-26860190, KAKENHI-PROJECT-25461128
[Journal Article] Suppression of the TGF-β1-induced protein expression of SNAI1 and N-cadherin by miR-199a.2014
- Author(s)
  Suzuki T, Mizutani K, Minami A, Nobutani K, Kurita S, Nagino M, Shimono Y, Takai Y.
- Journal Title
  
  Genes Cells.
  
  Volume: 19 Issue: 9 Pages: 667-675
- DOI
  10.1111/gtc.12166
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21227005, KAKENHI-PROJECT-23501268, KAKENHI-PROJECT-24790283, KAKENHI-PROJECT-24790284, KAKENHI-PUBLICLY-25130707, KAKENHI-PLANNED-26114007, KAKENHI-PROJECT-26251013, KAKENHI-PROJECT-26860190
[Journal Article] Genetic ablation of afadin causes mislocalization and deformation of Paneth cells in the mouse small intestinal epithelium.2014
- Author(s)
  Tanaka-Okamoto M, Itoh Y, Miyoshi J, Mizoguchi A, Mizutani K, Takai Y, Inoue M.
- Journal Title
  
  PLoS One.
  
  Volume: 9 Issue: 10 Pages: e110549-e110549
- DOI
  10.1371/journal.pone.0110549
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21227005, KAKENHI-PROJECT-24790284, KAKENHI-PLANNED-26114007, KAKENHI-PROJECT-26251013, KAKENHI-PROJECT-26860190
[Journal Article] Absence of primary cilia in cell cycle-arrested human breast cancer cells.2014
- Author(s)
  Nobutani K, Shimono Y, Yoshida M, Mizutani K, Minami A, Kono S, Mukohara T, Yamasaki T, Itoh T, Takao S, Minami H, Azuma T, Takai Y.
- Journal Title
  
  Genes Cells.
  
  Volume: 19 Issue: 2 Pages: 141-152
- DOI
  10.1111/gtc.12122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21227005, KAKENHI-PROJECT-23501268, KAKENHI-PROJECT-24790284, KAKENHI-PUBLICLY-25130707
[Journal Article] miR-214 and hypoxia down-regulate Necl-2/CADM1 and enhance ErbB2/ErbB3 signaling.2013
- Author(s)
  Momose, K.
- Journal Title
  
  Genes Cells
  
  Volume: 18 Issue: 3 Pages: 195-202
- DOI
  10.1111/gtc.12027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21227005, KAKENHI-PROJECT-23501268, KAKENHI-PROJECT-24790284, KAKENHI-PUBLICLY-23130510
[Journal Article] Reduction of the ST6 β-galactosamide α-2,6-sialyltransferase 1 (ST6GAL1)-catalyzed sialylation of nectin-like molecule 2/cell adhesion molecule 1 and enhancement of ErbB2/ErbB3 signaling by microRNA-199a.2013
- Author(s)
  Minami A, Shimono Y, Mizutani K, Nobutani K, Momose K, Azuma T, Takai Y.
- Journal Title
  
  J Biol Chem.
  
  Volume: 288 Issue: 17 Pages: 11845-11853
- DOI
  10.1074/jbc.m112.405993
- NAID
  40019873148
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21227005, KAKENHI-PROJECT-23501268, KAKENHI-PROJECT-24790284, KAKENHI-PUBLICLY-23130510
[Journal Article] Interaction of Necl-4/CADM4 with ErbB3 and integrin α6 β4 and inhibition of ErbB2/ErbB3 signaling and hemidesmosome disassembly.2013
- Author(s)
  Sugiyama H, Mizutani K, Kurita S, Okimoto N, Shimono Y, Takai Y.
- Journal Title
  
  Genes Cells.
  
  Volume: 18 Issue: 6 Pages: 519-528
- DOI
  10.1111/gtc.12056
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21227005, KAKENHI-PROJECT-23501268, KAKENHI-PROJECT-24790284, KAKENHI-PUBLICLY-23130510
[Journal Article] Interaction of nectin-like molecule 2 with integrin α6β4 and inhibition of the disassembly of integrin α6β4 from hemidesmosomes.2011
- Author(s)
  Mizutani, K. et al.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 286 Issue: 42 Pages: 36667-36676
- DOI
  10.1074/jbc.m110.200535
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21227005
[Patent] ErbB3活性化に伴うシグナルの伝達抑制物質及びそのスクリーニング方法2016
- Inventor(s)
  高井義美、水谷清人、慶田城迅
- Industrial Property Rights Holder
  高井義美、水谷清人、慶田城迅
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-096427
- Filing Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-26251013
[Presentation] 転移乳がん細胞におけるCXCR4の発現低下とがん休眠との関連2015
- Author(s)
  上田悠貴、信谷健太郎、下野洋平、水谷清人、鈴木俊裕、北山美登里、南晶洋、百瀬健次、宮脇恒太、赤司浩一、東健、高井義美
- Organizer
  第７４回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26251013
[Presentation] 転移乳がん細胞におけるCXCR4の発現低下とがん休眠との関連2015
- Author(s)
  上田悠貴、信谷健太郎、下野洋平、水谷清人、鈴木俊裕、北山美登里、南晶洋、百瀬健次、宮脇恒太、赤司浩一、東健、高井義美
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-26860190
[Presentation] 乳腺分化を制御する新規のネクチン依存性細胞間接着装置2015
- Author(s)
  圓岡真宏、北山美登里、水谷清人、高井義美
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26860190
[Presentation] Regulation by CXCR4 of competition between active and dormant states of breast cancer cell2015
- Author(s)
  Mizutani K., Nobutani K., Ueda Y., Shimono Y., and Takai Y.
- Organizer
  1st International Symposium on Cell Competition
- Place of Presentation
  Kyoto
- Year and Date
  2015-09-10
- Data Source
  KAKENHI-PROJECT-26860190
[Presentation] 乳腺分化を制御する新規のネクチン依存性細胞間接着装置2015
- Author(s)
  圓岡真宏、北山-吉田美登里、水谷清人、高井義美
- Organizer
  第３８回日本分子生物学会年会・第８８回日本生化学会大会　合同大会　(BMB2015)
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26251013
[Presentation] マイクロRNA-199aによるネクチン様分子２のシアル化修飾の減少とErbB2/ErbB3シグナル伝達の増強2013
- Author(s)
  下野洋平、南晶洋、水谷清人、信谷健太郎、百瀬健次、東健、高井義美
- Organizer
  第72回　日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24790284
[Presentation] ヒト正常乳腺と乳がん組織における細胞接着分子ネクチン、アファディン、およびネクチン様分子2013
- Author(s)
  北山美登里、下野洋平、信谷健太郎、水谷清人、向原徹、南博信、古森孝英、高井義美
- Organizer
  第72回　日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24790284
[Presentation] 大腸がん細胞においてマイクロRNA-214はNecl-2を抑制しErbB2/ErbB3シグナル伝達路を活性化する2012
- Author(s)
  百瀬健次、下野洋平、南晶洋、信谷健太郎、水谷清人、東健、高井義美
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌（北海道）
- Data Source
  KAKENHI-PROJECT-24790284
[Presentation] Neclとインテグリンα6β4の相互作用およびNeclによるへミデスモソーム崩壊制御機構2011
- Author(s)
  水谷清人　他
- Organizer
  第７０回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-21227005
[Presentation] Necl-2とインテグリンα_6β_4の相互作用およびNecl-2によるヘミデスモソーム崩壊抑制機構2010
- Author(s)
  水谷清人
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場(大阪)
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-21227005
[Presentation] マイクロRNA-199aはTGFβ1で誘導されるSNAI1とN-cadherinの発現を抑制する
- Author(s)
  鈴木俊裕、水谷清人、南晶洋、信谷健太郎、梛野正人、下野洋平、高井義美
- Organizer
  第73回　日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26860190
[Presentation] マイクロRNA-199aはTGFβ－1で誘導されるSNAI1とN-cadherinの発現を抑制する
- Author(s)
  鈴木俊裕、水谷清人、南晶洋、信谷健太郎、梛野正人、下野洋平、高井義美
- Organizer
  第７３回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26251013
[Presentation] マイクロRNA-199aはTGFβ1で誘導されるSNAI1とN-cadherinの発現を抑制する
- Author(s)
  鈴木俊裕、水谷清人、南晶洋、信谷健太郎、梛野正人、下野洋平、高井義美
- Organizer
  第73回　日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24790284
[Presentation] マイクロRNA-199aはTGFβ－1で誘導されるSNAI1とN-cadherinの発現を抑制する
- Author(s)
  鈴木俊裕、水谷清人、南晶洋、信谷健太郎、梛野正人、下野洋平、高井義美
- Organizer
  第７３回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-21227005

1. TAKAI YOSHIMI (60093514)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
2. SHIMONO Yohei (90594630)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
3. MIZOGUCHI Akira (90181916)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. OKAMOTO Miki (20332455)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. TOGASHI Hideru (90415240)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. OGITA Hisakazu (50379236)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KURITA Souichi (30595484)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. RIKITAKE Yoshiyuki (50419488)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. IKEDA Wataru (90362699)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 宮田宗明 (90582007)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MINAMI Hironobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Mizutani Kiyohito 水谷 清人

MIZUTANI Kiyohito 水谷 清人

Research Projects

Research Products

Co-Researchers

Roles and modes of action of nectins in heterotypic cell-cell adhesions

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation by Nectin-like molecules of ErbB family receptor signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation by Nectin-like molecules of hemidesmosome disassembly and reorganizationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of Cell Adhesion and Signaling in Cell Morphogenesis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Nectin-4 co-stimulates the prolactin receptor by interacting with SOCS1 and inhibiting its activity on the JAK2-STAT5a signaling pathway.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Novel Nectin-mediated Cell Adhesion Apparatus Which Is Implicated in Prolactin Receptor Signaling for Mammary Gland Development2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nectin spot: a novel type of nectin-mediated cell adhesion apparatus.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Downregulation of CXCR4 in Metastasized Breast Cancer Cells and Implication in Their Dormancy2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The cell adhesion molecule necl-4/cadm4 serves as a nobel regulator for contact inhibition of cell movement and proliferation.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Suppression of the TGF-β1-induced protein expression of SNAI1 and N-cadherin by miR-199a.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genetic ablation of afadin causes mislocalization and deformation of Paneth cells in the mouse small intestinal epithelium.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Absence of primary cilia in cell cycle-arrested human breast cancer cells.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] miR-214 and hypoxia down-regulate Necl-2/CADM1 and enhance ErbB2/ErbB3 signaling.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reduction of the ST6 β-galactosamide α-2,6-sialyltransferase 1 (ST6GAL1)-catalyzed sialylation of nectin-like molecule 2/cell adhesion molecule 1 and enhancement of ErbB2/ErbB3 signaling by microRNA-199a.2013

Author(s)

Journal Title

DOI

NAID

Data Source

Mizutani Kiyohito 水谷清人

MIZUTANI Kiyohito 水谷清人