Uehara Akira 上原明

… Alternative Names

UEHARA Akira 上原明

上原明ウエハラアキラ

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Researcher Number	60140745
Other IDs
Affiliation (based on the past Project Information) *help	2014 – 2017: 福岡大学, 医学部, 准教授 2010 – 2012: 福岡大学, 医学部, 准教授 2007 – 2008: 福岡大学, 医学部, 准教授 2003 – 2006: Fukuoka University, School of Medicine, Associate Professor, 医学部, 助教授 2000 – 2002: 福岡大学, 医学部, 助手 … More 1996: 福岡大学, 医学部, 助手 1994: Fukuoka Univ., Sch.Med.Joshu, 医学部, 助手 1993 – 1994: 福岡大学, 医学部, 講師 1988 – 1992: 福岡大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator General physiology / Neurophysiology and muscle physiology / General physiology / 神経・脳内生理学 / Neurophysiology and muscle physiology Except Principal Investigator Pediatrics / General anatomy (including Histology/Embryology) / Neurophysiology and muscle physiology
Keywords	Principal Investigator Heart / Sarcoplasmic reticulum / 小胞体 / Calcium / sarcoplasmic reticulum / 心臓 / Ca / リアノジン受容体 / 興奮収縮連関 / Ca^<2+> … More / Ryanodine receptor / イオンチャネル / 心筋 / 筋生理学 / Excitable cells / Na channels / Planar lipid bilayer / Naチャネル / 興奮性細胞 / Naチャンネル / 人工脂質膜法 / Junctophilin / Excitation-contraction coupling / Cardiomyocyte / Physiology / Caストア / ジャンクトフィリン / 心筋細胞 / 生理学 / single channel currents / cardiac muscle / ionic channels / 単一イオンチャネル電流 / 単一イオンチャネル / Ion Channels / Sarcoplasmic Reticulum / ion channels / arrythmia / calcium / 不整脈 / カルシウムイオン / 心筋生理学 / リアノジン … More Except Principal Investigator store-operated Ca2+ influx / 遺伝子 / 中枢神経 / てんかん / 受容体 / チャネル / rat / spleen / catenin / vascular endothelial cadherin / adherens junction / transient receptor potential channel / sinus endothelial cells / アドヘレンスジャンクション / Ca貯蔵小胞体 / ストレスファイバー / IP3レセプター / Caチャネル / リアノジンレセプター / アドヒーレンスジャンクション / stored-operated Ca2+influx / ラット / 脾臓 / カテニン / VE-カドヘリン / アドヒーレンスジャンクシ / 容量依存性Caチャネル / 脾洞内皮細胞 / Neurotransmitter / Transgenone / Channelopahtv / Channel / Epilepsy / 神経伝達物質 / 睡眠 / 遺伝子改変動物 / モデル動物 / 神経伝達 / 遺伝子組換え / チャネロパチー / 小胞体 / 悪性高熱 / 相互作用 / カルシウムチャネル / 筋小胞体 / リアノジン受容体 / 小児神経学 Less

Ventricular tachycardia triggered by augumented Ca leak through ryanodine receptor carrying point mutation: In vitro reconstruction of arrhythmogenicityPrincipal Investigator
- Principal Investigator
  
  Uehara Akira
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Fukuoka University
Study on regulation mechanisms of SR Ca2+-induced Ca2+ release by functional sub-domain of ryanodine receptorPrincipal Investigator
- Principal Investigator
  
  UEHARA Akira
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Fukuoka University
Regulation of ryanodine receptor channel by interdomain interaction
- Principal Investigator
  
  MURAYAMA Takashi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Juntendo University
Genetic analyses and generation of genetic engineered animals for childhood epilepsy focusing on ion channel abnormalities
- Principal Investigator
  
  HIROSE Shinichi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pediatrics
- Research Institution
  Fukuoka University
Analysis of dynamics of splenic sinus endothelial cells for controlling of blood cell passage
- Principal Investigator
  
  UEHARA Kiyoko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Fukuoka University
Physiological roles of junctional membrane complex formed by Ca^<2+> store and plasma membranes in excitation-contraction coupling of cardiac myocytes.Principal Investigator
- Principal Investigator
  
  UEHARA Akira
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Fukuoka University
Identification of the responsible genes for childhood epilepsies targeting at channels and receptors expressed in the brain
- Principal Investigator
  
  HIROSE Shinichi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Fukuoka University
Study with knockout mice on the activation mechanisms of the capacitative Ca^<2+> entry channel existing in the cardiac myocytePrincipal Investigator
- Principal Investigator
  
  UEHARA Akira
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Fukuoka University
Electrophysiologicalestudy on the cardiac ryanodine receptor operating the Ca-induced Ca-release mechanisms.Principal Investigator
- Principal Investigator
  
  AKIRA Uehara
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Fukuoka University
脳型リアノジン受容体の電気生理学的、遺伝子工学的研究Principal Investigator
- Principal Investigator
  
  上原明
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  神経・脳内生理学
- Research Institution
  Fukuoka University
Modification mechanisms of single ionic channel currents from cardiac sarcoplasmic reticulum and mitochondria by physiologically active substances.Principal Investigator
- Principal Investigator
  
  UEHARA Akira
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  神経・脳内生理学
- Research Institution
  Fukuoka University
Planar lipid bilayr and patch clamp studies on the single channel currents of cardiac sarcop lasmic reticulum.Principal Investigator
- Principal Investigator
  
  UEHARA Akira
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Fukuoka University
Comparison of Sodium Channel Currents Between Various Excitable Cells by Planar Lipid Bilayer and Patch Clamp MethodsPrincipal Investigator
- Principal Investigator
  
  UEHARA Akira
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Fukuoka University

All 2017 2016 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004

All Journal Article Presentation

[Journal Article] Extensive Ca2+ leak through K4750Q cardiac ryanodine receptors caused by cytosolic and luminal Ca2+ hypersensitivity.2017
- Author(s)
  Akira Uehara, Takashi Murayama, Midori Yasukochi, Michael Fill, Minoru Horie,Toru Okamoto, Yoshiharu Matsuura, Kiyoko Uehara, Takahiro Fujimoto, Takashi Sakurai,and Nagomi Kurebayashi.
- Journal Title
  
  J Gen Physiol
  
  Volume: 149 Pages: 199-218
- Data Source
  KAKENHI-PROJECT-26460305
[Journal Article] Differentiated localizations of phosphorylated focal adhesion2016
- Author(s)
  Uehara K and Uehara A
- Journal Title
  
  Cell Tiss Res
  
  Volume: 掲載確定 Issue: 3 Pages: 611-622
- DOI
  10.1007/s00441-015-2350-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460305
[Journal Article] Extensive Ca2+ leak through K4750Q cardiac ryanodine receptors caused by cytosolic and luminal Ca2+ hypersensitivity.2016
- Author(s)
  Uehara A, Horie M, et al.
- Journal Title
  
  Journal of General Physiology
  
  Volume: 149 Issue: 2 Pages: 199-218
- DOI
  10.1085/jgp.201611624
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818, KAKENHI-PROJECT-15K08243, KAKENHI-PROJECT-26460305, KAKENHI-PROJECT-16K08507
[Journal Article] Integrin in endothelial cells of rat splenic sinus: an immunohistochemical and untrastructural study.2014
- Author(s)
  Uehara K and Unhara A
- Journal Title
  
  Cell Tissue Research
  
  Volume: 356 Issue: 1 Pages: 183-189
- DOI
  10.1007/s00441-014-1796-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460305
[Journal Article] CLCA splicing isoform associated with adhesion through b1-integrin and its scaffolding protein YamazakiJ2013
- Author(s)
  Okamura K, K Uehara , Hatta M
- Journal Title
  
  J Biol Chem
  
  Volume: 288 No.7 Issue: 7 Pages: 4831-4843
- DOI
  10.1074/jbc.m112.396481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500366
[Journal Article] P2Y1, P2Y6, and P2Y12 receptors in rat splenic sinus endothelial cells: an immunohistochemical and ultrastructural study2011
- Author(s)
  Uehara K, Uehara A.
- Journal Title
  
  Histochem Cell Biol
  
  Volume: 136(5) Issue: 5 Pages: 557-67
- DOI
  10.1007/s00418-011-0859-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500366
[Journal Article] Vimentin intermediate filaments: the central base in sinus endothelial cells of the rat spleen2010
- Author(s)
  Uehara K, Uehara A.
- Journal Title
  
  Anat Rec
  
  Volume: 293(12) Issue: 12 Pages: 2034-43
- DOI
  10.1002/ar.21210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500366
[Journal Article] de novo KCNQ2 mutation detected innon-familial benign neonatal convulsions2009
- Author(s)
  Ishii A, Fukuma G, Uehara A, Miyajima T, MakitaY, Hamachi A, Yasukochi M, Inoue T, Yasumoto S,Okada M, Kaneko S, Mitsudome A, Hirose S
- Journal Title
  
  BrainDev 31(1)
  
  Pages: 27-33
- Data Source
  KAKENHI-PROJECT-18209035
[Journal Article] Altered KCNQ3 potassium channel function caused by the W309R pore-helix mutation found in human epilepsy2008
- Author(s)
  Uehara A, Nakamura Y, Shioya T, Hirose S, Yasukochi M, Uehara K.
- Journal Title
  
  J Membr Biol 222(2)
  
  Pages: 55-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209035
[Journal Article] Cell membrane-derived lysophosphatidylcholine activates cardiac ryanodine receptor channels.2007
- Author(s)
  Uehara A,. et al.
- Journal Title
  
  Pflugers Arch. 453(4)
  
  Pages: 455-462
- Data Source
  KAKENHI-PROJECT-18209035
[Journal Article] Distribution of adherens junction mediated by VE-cadherin complex In rat spleen sinus endothelial cells2006
- Author(s)
  K.Uehara
- Journal Title
  
  Cell and Tissue Research 323
  
  Pages: 417-424
- Data Source
  KAKENHI-PROJECT-16590159
[Journal Article] Distribution of adherens junction mediated by VE-cadherin complex in rat spleen sinus endothelial cells2006
- Author(s)
  K.Uehara
- Journal Title
  
  Cell and Tissue Research 323
  
  Pages: 417-424
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590159
[Journal Article] Distribution of adherens junction mediated by VE-cadherin complex in rat spleen sinus endothelial cells2006
- Author(s)
  K.Uehara
- Journal Title
  
  Ceall and Tissue Research 323
  
  Pages: 417-424
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590159
[Journal Article] Localization of TRCP1 channel in the sinus endothelial cells of rat spleen2005
- Author(s)
  K.Uehara
- Journal Title
  
  Histochemistry and Cell Biology 123
  
  Pages: 347-356
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590159
[Journal Article] Localization of TRPC1 channel in the sinus endothelial cells of rat spleen2005
- Author(s)
  K.Uehara
- Journal Title
  
  Histochemistry and Cell Biology 123
  
  Pages: 347-356
- Data Source
  KAKENHI-PROJECT-16590159
[Journal Article] Localization of ryanodine receptor 3 in the sinus endothelial cells of the rat spleen2004
- Author(s)
  K.Uehara, H.Onoue, L.H.Jeyakumar, S.Fleischer, A.Uehara
- Journal Title
  
  Cell and Tissue Research 317
  
  Pages: 137-145
- Data Source
  KAKENHI-PROJECT-16590159
[Presentation] リアノジン受容体チャネル催不整脈性変異によるカルシウム調節機構障害2016
- Author(s)
  上原　明
- Organizer
  日本生理学会
- Place of Presentation
  北海道
- Year and Date
  2016-03-20
- Data Source
  KAKENHI-PROJECT-26460305
[Presentation] リアノジン受容体の催不整脈性変異によるチャネル不安定化機構2014
- Author(s)
  上原　明
- Organizer
  筋生理の集い
- Place of Presentation
  慈恵医大
- Year and Date
  2014-12-06
- Data Source
  KAKENHI-PROJECT-26460305
[Presentation] 脾洞内皮細胞がタガ線維に接着するための分子インテグリンの局在-インテグリンβ1の関与-2013
- Author(s)
  上原清子
- Organizer
  第118回日本解剖学会
- Place of Presentation
  高知
- Data Source
  KAKENHI-PROJECT-22500366
[Presentation] Immunohistochmical localization of integrins in rat splenic sinus endothelial cells2012
- Author(s)
  上原清子
- Organizer
  Joint Meeting of the 45th annual meeting of the Japanese Society of Developmental Biologisits & the 64th annual meeting of the Japan Society for Cell Biology.
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22500366
[Presentation] 脾洞内皮細胞とタガ線維の接着部位におけるインテグリンの局在2012
- Author(s)
  上原清子
- Organizer
  第117回日本解剖学会
- Place of Presentation
  山梨
- Data Source
  KAKENHI-PROJECT-22500366
[Presentation] Immunohistochemical localization of P2Y receptors, PLC-b, and IP3R-1 in rat splenic sinus endothelial clls2011
- Author(s)
  上原清子
- Organizer
  第63回日本細胞生物学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22500366
[Presentation] ワークショップ発表:電子顕微鏡画像への第一歩～光学顕微鏡画像との連関2011
- Author(s)
  上原清子
- Organizer
  第67回日本顕微鏡学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22500366
[Presentation] 脾洞内皮細胞におけるヌクレオチド受容体の局在2011
- Author(s)
  上原清子
- Organizer
  第116回日本解剖学会・第88回日本生理学会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22500366
[Presentation] Vimentin filaments play the role as the central base in the rat splenic endothelial clls2010
- Author(s)
  上原清子
- Organizer
  第62回日本細胞生物学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22500366
[Presentation] A De Novo KCNQ2 Mutation Detected in Benign Neonatal Convulsions : Possible Involvement Of Genes responsible for Rare Inherited Epilepsy in Idiopathic Epilepsy2008
- Author(s)
  Ishii A., Fukuma G., Uehara A., Yasukochi M., Miyajima T., Makita Y., Hamachi A., Yonetani M., Inoue T., Okada M., Kaneko S., Hirose S.
- Organizer
  The 4^<th> Congress of Asian Society for Pediatric Research
- Place of Presentation
  Hawaii, USA
- Data Source
  KAKENHI-PROJECT-18209035

1. OGATA s. (30131816)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. OGAWA k. (60078780)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. HIROSE Shinichi (60248515)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
4. UEHARA Kiyoko (00084244)

# of Collaborated Projects: 3 results

# of Collaborated Products: 21 results
5. IMANAGA Ittusei (40078613)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. MISUMI Yoshio (10148877)

# of Collaborated Projects: 2 results

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7. ARAKI Kimi (90211705)

# of Collaborated Projects: 2 results

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8. SAITO Ryo (80122696)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. TAKANO Yukio (50113246)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. DESHIMARU Masanobu (70309889)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. MURAYAMA Takashi (10230012)

# of Collaborated Projects: 1 results

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12. KUREBAYASHI Nagomi (50133335)

# of Collaborated Projects: 1 results

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13. MORONE Nobuhiro (50399680)

# of Collaborated Projects: 1 results

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14. TAKAHAGI Takayuki (40271069)

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15. NAKASHIO a. (40227773)

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16. MATSUSHITA Misao (00165812)

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17. MITSUDOME Akihisa (30038749)

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18. KANEKO Sunao (40106852)

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19. OKADA Motohiro (10281916)

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20. KIYANAGI Midori (20153687)

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21. TANAKA Yoko (10207152)

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22. 塩谷孝夫 (20253594)

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23. 上野伸哉 (00312158)

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24. 堀江稔

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Uehara Akira 上原 明

UEHARA Akira 上原 明

上原 明 ウエハラ アキラ

Research Projects

Research Products

Co-Researchers

Ventricular tachycardia triggered by augumented Ca leak through ryanodine receptor carrying point mutation: In vitro reconstruction of arrhythmogenicityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on regulation mechanisms of SR Ca2+-induced Ca2+ release by functional sub-domain of ryanodine receptorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of ryanodine receptor channel by interdomain interaction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genetic analyses and generation of genetic engineered animals for childhood epilepsy focusing on ion channel abnormalities

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of dynamics of splenic sinus endothelial cells for controlling of blood cell passage

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Physiological roles of junctional membrane complex formed by Ca^<2+> store and plasma membranes in excitation-contraction coupling of cardiac myocytes.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of the responsible genes for childhood epilepsies targeting at channels and receptors expressed in the brain

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study with knockout mice on the activation mechanisms of the capacitative Ca^<2+> entry channel existing in the cardiac myocytePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Electrophysiologicalestudy on the cardiac ryanodine receptor operating the Ca-induced Ca-release mechanisms.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

脳型リアノジン受容体の電気生理学的、遺伝子工学的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Modification mechanisms of single ionic channel currents from cardiac sarcoplasmic reticulum and mitochondria by physiologically active substances.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Planar lipid bilayr and patch clamp studies on the single channel currents of cardiac sarcop lasmic reticulum.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Comparison of Sodium Channel Currents Between Various Excitable Cells by Planar Lipid Bilayer and Patch Clamp MethodsPrincipal Investigator

Principal Investigator

Uehara Akira 上原明

UEHARA Akira 上原明

上原明ウエハラアキラ