Akaji Kenichi 赤路健一

… Alternative Names

AKAJI Kenichi 赤路健一

赤路健一アカジケンイチ

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Researcher Number	60142296
Other IDs
External Links
Affiliation (Current)	2025: 京都薬科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2013 – 2019: 京都薬科大学, 薬学部, 教授 2011: 京都薬科大学, 薬学部, 教授 2009 – 2010: Kyoto Prefectural University of Medicine, 医学研究科, 教授 2006 – 2007: 京都府立医科大学, 医学研究科, 教授 2001 – 2002: 大阪大学, たんぱく質研究所, 助教授 … More 1999: Institute for Protein Research, Osaka University, Associate Professor, 蛋白質研究所, 助教授 1992 – 1998: 京都薬科大学, 薬学部, 助教授 1990: 京都薬科大学, 薬学部, 助教授 1986 – 1987: 京都大学, 薬学部, 助手 Less
Review Section/Research Field	Principal Investigator Chemical pharmacy / Drug development chemistry / Chemical pharmacy Except Principal Investigator Chemical pharmacy / Drug development chemistry / 医薬分子機能学 / Physical pharmacy / Bioorganic chemistry / Biological Sciences
Keywords	Principal Investigator 阻害剤 / プロテアーゼ / SARS / 固相合成 / 縮合剤 / solid pahse synthesis / コンビナトリアル合成 / Protease / 医薬品化学 / プロテアーゼ阻害剤 … More / HTLV-1 / 薬学 / 新型コロナウイルス / アルツハイマー病 / 創薬 / aziridine / miraziridine A / inhibitor / 3CL-protease / Tokaramide A / アジリジン / Miraziridine A / 3CLプロテアーゼ / library / Solid phase synthesis / Transition state mimetic / Enzyme inhibitor / Asvmmetirc aldol reaction / ライブラリー / ヒト白血病ウイルス / 基質遷移状態 / 酵素阻害剤 / 不斉アルドール反応 / CIP reagent / dolastatin 15 / coupling reaction / デブシペプチド / Nメチルアミノ酸 / 固相上縮合 / CIP試薬 / ドラスタチン15 / 縮合反応 / fibrinogen binding / RGD structure / Heck reaction / intramolecular cyclization / RGD誘導体 / Heck反応 / フィブリノーゲン結合阻害 / RGD構造 / ヘック反応 / 分子内環化反応 / thiazoline / dialkyl amino acid / mirabazole / anti-cancer alkaloid / coupling reagent / チアゾリン / ジアルキルアミノ酸 / ミラバゾール / 抗腫瘍アルカロイド / Prodrug / AIDS / dipeptide / Inhibitor / エイズ薬 / プロドラッグ / エイズ / ジペプチド / BACE1 / 創薬科学 / 縮環構造 / 複合体構造解析 / 疎水性相互作用 / Retro-Inverso / Dアミノ酸 / 構造解析 / 化学合成 / インスリン / ペプチド合成 / シリルクロリド / 位置選択的形成 / ジスルフィド結合 / ヒトインスリン … More Except Principal Investigator ペプチド合成 / HIVプロテアーゼ阻害剤 / 基質遷移状態誘導体 / 酵素阻害剤 / 分子認識 / ドラッグデザイン / 抗エイズ薬 / HIVプロテアーゼ / ペプチドミミック / 基質遷移状態 / エイズ治療薬 / 酵素阻害剤複合体 / 抗ウイルス薬 / 抗HIV活性 / X線結晶構造解析 / コンフォーメーション解析 / アスパラギン酸プロテアーゼ / Anti-HIV Activity / Enzyme Inhibitor / Peptide Synthesis / Substrate Transition State / AIDS Therapeutics / Molecular Recognition / 酵素・阻害剤複合体 / 薬剤耐性 / ペプチドミメティック / 効率的固相合成法 / プロテアーゼ阻害剤 / 基質遷移状態概念 / 分子設計 / HIV Protease Inhibitor / コンフォメーション / HIV protease inhibitor / BACE1 / アルツハイマー病 / ＥＧＦレセプター / 二量化阻害 / EGFレセプター / コンフォメーション解析 / 抗ATL薬 / HTLVプロテアーゼ阻害剤 / レニン阻害剤 / ABCトランスポーター / アミロイドーシス / 脂質異常症 / コレステロール代謝 / ＨＤＬ / 糖鎖 / 脂質膜 / アミロイド / 抗体 / HDL / アポリポタンパク質 / ピペリジン / ピロリジン / アミジノ基 / 低分子阻害剤 / 二量化アーム / 創薬研究 / 抗がん薬 / アラニン置換 / 共焦点レーザー顕微鏡 / 抗がん薬リード / 細胞内輸送 / フルオレセイン標識 / フルオレセイン / 環状ペプチド / 細胞内薬物送達分子 / 抗がん活性ペプチド / 蛍光プローブ / 二量体化アーム / 1 M trimethylsilyl trifluoromethanesulfonate / cancer cell growth / mitogenic factor / human transforming growth factor-<alpha> / タリウム(【III】)酸化 / トリメチルシリルトリフラート / 癌診断 / ジスルフィド形成反応 / 【N^(ih)】-benzyloxymethyl histidine / ヒト腫瘍細胞増殖因子α / トリフルオロメタンスルホン酸銀塩 / 1Mトリメチルシリルトリフルオロメタンスルホネート / 腫瘍細胞増殖 / 成長因子 / ヒト腫瘍増殖因子-α / Trimethylsilyl trifluoromethanesulfonate / Human insulin-like growth factor-I / トリフルオロメタン脱保護法 / β-シクロヘプチルアスパルテイト / トリメチルシリルトリフルオロメタンスルホネート脱保護法 / 1-アダマンチルシステイン / インスリン様成長因子 / トリメチルシリルブロマイド / トリメチルシリルトリフレート / インシュリン様成長因子 / Double Drug / HIV protease / HIV Protease / Anti-AIDS Drug / Drug Resistant Virus / X-ray Crystallography / Conformational Analysis / Peptide synthesis / Substrate Transition State Analog / Enzyme・Inhibitor Complex / HIV Protease Inhibitors / 薬剤耐性ウイルス / 薬物代謝 / キノスタチン / 抗HIV薬 / peptide synthesis / prodrug / kynostatin / drug design / anti-HIV drug / activiral drug / peptide mimic / anti-AIDS drug / 閉環メタセシス / 遷移状態アナログ / ヒドロキシエチルアミン / 側鎖改変 / 親和性増強 / 二量化阻害ペプチド / 質量分析 / キャピラリー電気泳動 / スクリーニング / レセプター創薬 / ループ構造模倣環状ペプチド / 酵素活性中心 / 固相合成 / ウイルスプロテアーゼ / 構造規制 / NMR / リ-ドオプチマイゼーション / キノスタチン-272 / HTLV-1プロテアーゼ / ATL治療薬 / 高血圧症治療薬 / ペプチドmimic / HIVプロテア-ゼ / レニン / アスパラギン酸プロテア-ゼ Less

Strategies for transformation of a substrate-based protease inhibitor to non-peptide inhibitorPrincipal Investigator
- Principal Investigator
  
  Akaji Kenichi
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kyoto Pharmaceutical University
Development of novel BACE1 inhibitors based on the N-amidino nitrogen-containing ring structure
- Principal Investigator
  
  Kobayashi Kazuya
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kyoto Pharmaceutical University
Studies on new chemical probes development that assumed dimeric interface of the EGF receptor ectodomain a target
- Principal Investigator
  
  Mizuguchi Takaaki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo Medical and Dental University
Design of non-peptide inhibitors based on structure analyses of the protease/inhibitor complexPrincipal Investigator
- Principal Investigator
  
  Akaji Kenichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kyoto Pharmaceutical University
Development of novel BACE1 inhibitors: Structure activity relationship study based on the substrate sequence
- Principal Investigator
  
  KOBAYASHI Kazuya
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kyoto Pharmaceutical University
Physicochemical mechanism on formation and metabolism of HDL particles by apolipoproteins
- Principal Investigator
  
  Saito Hiroyuki
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyoto Pharmaceutical University
  The University of Tokushima
Systematic structure optimization of the EGF receptor-inhibiting peptide through use of a screening technology
- Principal Investigator
  
  SAITO Kazuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
Development of a novel persistent protease inhibitor containing D-amino acidPrincipal Investigator
- Principal Investigator
  
  AKAJI Kenichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kyoto Pharmaceutical University
  Kyoto Prefectural University of Medicine
Development of SARS virus inhibitor using unusual amino acid-containing natural products as seedsPrincipal Investigator
- Principal Investigator
  
  AKAJI Kenichi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kyoto Prefectural University of Medicine
Combinatorial Synthesis of Transition State Mimetic Inhibitor Using Asymmetric Aldol, ReactionPrincipal Investigator
- Principal Investigator
  
  AKAJI Kenichi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka University
変異HIVに対する阻害剤のデザインとウイルス病原性の分子機構解明への展開
- Principal Investigator
  
  木曽良明
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto Pharmaceutical University
Study on strategy for AIDS drugs against mutant viruses
- Principal Investigator
  
  KISO Yoshiaki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  医薬分子機能学
- Research Institution
  KYOTO PHARMACEUTICAL UNIVERSITY
Intramolecularcyclization by solid-phase olefination and its application to combinatorial synthesisPrincipal Investigator
- Principal Investigator
  
  AKAJI Kenichi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka University
  Kyoto Pharmaceutical University
Convergent synthesis and SAR of dolastatin 15 by solid phase couplingPrincipal Investigator
- Principal Investigator
  
  AKAJI Kenichi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka University
  Kyoto Pharmaceutical University
変異HIVに対する阻害剤のデザインとウイルス病原性の分子機構解明への展開
- Principal Investigator
  
  木曽良明
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto Pharmaceutical University
アスパラギン酸プロテアーゼ活性中心をターゲットとしてデザインされた阻害剤の開発
- Principal Investigator
  
  木曽良明
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto Pharmaceutical University
Molecular design of HIV protease inhibitors restricted to active conformation
- Principal Investigator
  
  KISO Yoshiaki
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  KYOTO PHARMACEUTICAL UNIVERSITY
変異HIVに対する阻害剤のデザインとウイルス病原性の分子機構解明への展開
- Principal Investigator
  
  木曽良明
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto Pharmaceutical University
アスパラギン酸プロテアーゼ活性中心をターゲットとしてデザインされた阻害剤の開発
- Principal Investigator
  
  木曽良明
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto Pharmaceutical University
Joint Study on AIDS Drug Based on HIV Protease
- Principal Investigator
  
  KISO Yoshiaki
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Chemical pharmacy
- Research Institution
  KYOTO PHARMACEUTICAL UNIVERSITY
Convergent Synthesis of Anti-Cancer Alkaloid, Mirabazols, using a New Coupling ReagentPrincipal Investigator
- Principal Investigator
  
  AKAJI Kenichi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kyoto Pharmaceutical University
プロテアーゼ・阻害剤複合体の構造解析に基づく阻害剤の構造活性相関研究
- Principal Investigator
  
  木曽良明
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto Pharmaceutical University
ATL治療薬をめざしたHTLV-1プロテアーゼ阻害剤のデザイン
- Principal Investigator
  
  木曽良明
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto Pharmaceutical University
変異HIVに対する阻害剤のデザインとウイルス病原性の分子機構解明への展開
- Principal Investigator
  
  木曽良明
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto Pharmaceutical University
Molecular design of AIDS therapeutics based on molecular recognition of enzymes.
- Principal Investigator
  
  KISO Yoshiaki
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Kyoto Pharmaceutical University
Development of Low Molecular Weight HIV Protease Inhibitor for Oral UsePrincipal Investigator
- Principal Investigator
  
  AKAJI Kenichi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kyoto Pharmaceutical University
プロテアーゼ・阻害剤複合体の構造解析に基づく阻害剤の構造活性相関研究
- Principal Investigator
  
  木曽良明
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto Pharmaceutical University
ATL治療薬をめざしたHTLV-1プロテアーゼ阻害剤のデザイン
- Principal Investigator
  
  木曽良明
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto Pharmaceutical University
ATL治療薬をめざしたHTLV-1プロテアーゼ阻害剤のデザイン
- Principal Investigator
  
  木曽良明
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto Pharmaceutical University
アスパラギン酸プロテアーゼの基質遷移状態概念に基づく医薬品の分子設計
- Principal Investigator
  
  木曽良明
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kyoto Pharmaceutical University
位置選択的架橋反応を用いるヒトインスリンの高効率合成Principal Investigator
- Principal Investigator
  
  赤路健一
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kyoto Pharmaceutical University
Joint study on protease-targeted anti-AIDS drugs
- Principal Investigator
  
  KISO Yoshiaki, 木曾良明
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kyoto Pharmaceutical University
アスパラギン酸プロテアーゼの基質遷移状態概念に基づく阻害剤の分子設計と合成研究
- Principal Investigator
  
  木曽良明
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kyoto Pharmaceutical University
アスパラギン酸プロテア-ゼの基質遷移状態概念に基づく阻害剤の分子設計と合成研究
- Principal Investigator
  
  KISO Yoshiaki
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kyoto Pharmaceutical University
Synthetic Studies on Human Transforming Growth Factor(hTGF)-<alpha>
- Principal Investigator
  
  FUJII Nobutaka
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kyoto University
Chemical Synthesis of Human Insulin-Like Growth Factor-I (IGF-I)
- Principal Investigator
  
  YAJIMA Haruaki
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kyoto University

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All Journal Article Presentation Book

[Book] 遺伝子医学MOOK別冊　次世代ペプチド医薬創製2014
- Author(s)
  赤路健一・編著
- Total Pages
  131
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-25460160
[Journal Article] Evaluation of an octahydroisochromene scaffold used as a novel SARS 3CL protease inhibitor2020
- Author(s)
  oshizawa, S.; Hattori, Y.; Kobayashi, K.; Akaji, K.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 28 Issue: 4 Pages: 115273-115273
- DOI
  10.1016/j.bmc.2019.115273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05104
[Journal Article] Convergent Synthesis of <i>trans</i>-2,6-Disubstituted Piperidine Alkaloid, (−)-<i>iso</i>-6-Spectaline by Palladium-Catalyzed Cyclization2019
- Author(s)
  Kameda, R.; Sohma, T.; Kobayashi, K.; Uchiyama, R.; Nosaka, K.; Konno, H.; Kenichi Akaji, K.; Hattori, Y.
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 67 Issue: 3 Pages: 253-257
- DOI
  10.1248/cpb.c18-00817
- NAID
  130007607123
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2019-03-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05104
[Journal Article] Evaluation of a non-prime site substituent and warheads combined with a decahydroisoquinolin scaffold as a SARS 3CL protease inhibitor2019
- Author(s)
  Ohnishi Kouji、Hattori Yasunao、Kobayashi Kazuya、Akaji Kenichi
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 27 Issue: 2 Pages: 425-435
- DOI
  10.1016/j.bmc.2018.12.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16J10921, KAKENHI-PROJECT-16H05104
[Journal Article] Structure-Activity Relationship Study of Cyclic Pentapeptide Ligands for Atypical Chemokine Receptor 3 (ACKR3)2018
- Author(s)
  Sekiguchi Haruka、Kuroyanagi Tomoko、Rhainds David、Kobayashi Kazuya、Kobayashi Yuka、Ohno Hiroaki、Heveker Nikolaus、Akaji Kenichi、Fujii Nobutaka、Oishi Shinya
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 61 Issue: 8 Pages: 3745-3751
- DOI
  10.1021/acs.jmedchem.8b00336
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04654, KAKENHI-PROJECT-16H05104
[Journal Article] Effects of replacement and addition of an amino acid contained in a cyclic peptide corresponding to a β-hairpin loop sequence of human EGF receptor2017
- Author(s)
  Kobayashi K, Mizuguchi T, Hattori Y, Ohara N, Ninomiya R, Iida M, Ooe H, Yamazaki Y, Takata M, Tamamura H, Akaji K
- Journal Title
  
  Journal of Peptide Science
  
  Volume: 印刷中 Issue: 7-8 Pages: 581-586
- DOI
  10.1002/psc.3004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18910, KAKENHI-PROJECT-16H05104
[Journal Article] Synthesis and evaluation of phenylisoserine derivatives for the SARS-CoV 3CL protease inhibitor2017
- Author(s)
  Konno Hiroyuki、Onuma Takumi、Nitanai Ikumi、Wakabayashi Masaki、Yano Shigekazu、Teruya Kenta、Akaji Kenichi
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 27 Issue: 12 Pages: 2746-2751
- DOI
  10.1016/j.bmcl.2017.04.056
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07709, KAKENHI-PROJECT-16H05104, KAKENHI-PROJECT-15K01804
[Journal Article] A dimer model of human calcitonin 13-32 forms an α-helical structure and robustly aggregates in 50% aqueous 2,2,2-trifluoroethanol solution2016
- Author(s)
  Kawashima, H.; Katayama, M.; Yoshida, R.; Akaji, K.; Asano, A.; Doi, M.
- Journal Title
  
  Journal of Peptide Science
  
  Volume: 22 Issue: 7 Pages: 480-484
- DOI
  10.1002/psc.2891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05104
[Journal Article] The polyphenol (-)-epigallocatechin-3-gallate prevents apoA-IIowa amyloidosis in vitro and protects human embryonic kidney 293 cells against amyloid cytotoxicity.2016
- Author(s)
  Nakajima H, Nishitsuji K, Kawashima H, Kuwabara K, Mikawa S, Uchimura K, Akaji K, Kashiwada Y, Kobayashi N, Saito H, Sakashita N
- Journal Title
  
  Amyloid
  
  Volume: 23 Issue: 1 Pages: 17-25
- DOI
  10.3109/13506129.2015.1113167
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08265, KAKENHI-PROJECT-25293006, KAKENHI-PROJECT-15K19488, KAKENHI-PROJECT-15K08629, KAKENHI-PROJECT-16K08712
[Journal Article] Iowa Mutant Apolipoprotein A-I (ApoA-IIowa) Fibrils Target Lysosomes.2016
- Author(s)
  Kameyama H., Nakajima H., Nishitsuji K., Mikawa S., Uchimura K., Kobayashi N., Okuhira K., Saito H., and Sakashita N.
- Journal Title
  
  Sci. Rep.
  
  Volume: 6 Issue: 1 Pages: 30391-30391
- DOI
  10.1038/srep30391
- NAID
  120006534966
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293006, KAKENHI-PROJECT-15K19488, KAKENHI-PROJECT-15K08629, KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-16K08712, KAKENHI-PROJECT-15K08265
[Journal Article] Heparin promotes fibril formation by the N-terminal fragment of amyloidogenic apolipoprotein A-I2016
- Author(s)
  Mikawa, S., Mizuguchi, C., Nishitsuji, K., Baba, T., Shigenaga,A., Shimanouchi, T., Sakashita, N., Otaka, A., Akaji, K., Saito, H.
- Journal Title
  
  FEBS Letters
  
  Volume: 590(20) Issue: 20 Pages: 3492-3500
- DOI
  10.1002/1873-3468.12426
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16J01828, KAKENHI-PROJECT-25293006, KAKENHI-PROJECT-15K19488, KAKENHI-PROJECT-16K08712
[Journal Article] Design and synthesis of a series of serine derivatives as small molecule inhibitors of the SARS coronavirus 3CL protease2016
- Author(s)
  Konno, H.; Wakabayashi, M.; Takanuma, D.; Saito, Y.; Akaji, K.
- Journal Title
  
  Bioorganic and Medicinal Chemistry
  
  Volume: 24 Issue: 6 Pages: 1241-1254
- DOI
  10.1016/j.bmc.2016.01.052
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05104
[Journal Article] Structural basis for the development of SARS 3CL protease inhibitors from a peptide mimic to an aza-decaline scaffold2016
- Author(s)
  Teruya, K.; Hattori, Y.; Shimamoto, Y.; Kobayashi, K.; Sanjoh, A.; Nakagawa, A.; Yamashita, E.; Akaji, K.
- Journal Title
  
  Peptide Science
  
  Volume: 106 Issue: 4 Pages: 391-403
- DOI
  10.1002/bip.22773
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05104
[Journal Article] Studies on Identification of Active Sites of an Inhibitory Cyclic Peptide against EGF Receptor Dimerization2015
- Author(s)
  Mizuguchi T, Yamazaki Y, Kobayashi K, Ooe H, Iida M, Ninomiya R, Saito K, Akaji K, Tamamura H.
- Journal Title
  
  Peptide Science
  
  Volume: 2014 Pages: 163-164
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26893061
[Journal Article] Cellular Interaction and Cytotoxicity of the Iowa Mutation of Apolipoprotein A-I (ApoA-IIowa) Amyloid Mediated by Sulfate Moieties of Heparan Sulfate2015
- Author(s)
  Kuwabara, K., Nishitsuji, K., Uchimura, K., Hung, S.C., Mizuguchi, M., Nakajima, H., Mikawa, S., Kobayashi, N., Saito, H., and Sakashita, N.
- Journal Title
  
  J Biol Chem
  
  Volume: 290 Issue: 40 Pages: 24210-24221
- DOI
  10.1074/jbc.m115.652545
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08265, KAKENHI-PROJECT-15K08629, KAKENHI-PROJECT-15K19488, KAKENHI-PROJECT-25460709, KAKENHI-PROJECT-25293006
[Journal Article] Evaluation of transition-state mimics in a superior BACE1 cleavage sequence as peptide-mimetic BACE1 inhibitors2015
- Author(s)
  Hattori Y, Kobayashi K, Deguchi A, Nohara Y, Akiyama T, Teruya K, Sanjoh A, Nakagawa A, Yamashita E, Akaji K
- Journal Title
  
  Bioorganic and Medicinal Chemistry
  
  Volume: 23 Issue: 17 Pages: 5626-5640
- DOI
  10.1016/j.bmc.2015.07.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K01804, KAKENHI-PROJECT-25460160
[Journal Article] Synthesis of a pyrrolidine analog of a tetrahydrofuran containing acetogenin, cis-solamin2015
- Author(s)
  Ohnishi K, Sakurai H, Katsuyama M, Kobayashi K, Makabe H, Teruya K, Akaji K, Hattori Y.
- Journal Title
  
  HETEROCYCLES
  
  Volume: 91 Issue: 3 Pages: 573-582
- DOI
  10.3987/com-14-13163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K01804, KAKENHI-PROJECT-25460160
[Journal Article] Studies on identification of active sites of an inhibitory cyclic peptide against EGF receptor dimerization.2015
- Author(s)
  Takaaki Mizuguchi, Yukako Yamazaki, Kazuya Kobayashi, Honami Ooe, Mika Iida, Ryunosuke Ninomiya, Kazuki Saito, Kenichi Akaji, Hirokazu Tamamura
- Journal Title
  
  Peptide Science
  
  Volume: 2014 Pages: 163-164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590134
[Journal Article] FRET evidence for untwisting of amyloid fibrils on the surface of model membranes2015
- Author(s)
  Gorbenko, G., Trusova, V., Girych, M., Adachi, E., Mizuguchi, C., Akaji, K., and Saito, H.
- Journal Title
  
  Soft Matter
  
  Volume: 11 Issue: 31 Pages: 6223-6234
- DOI
  10.1039/c5sm00183h
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293006
[Journal Article] Fused-ring structure of decahydroisoquinolin as a novel scaffold for SARS 3CL protease inhibitors2015
- Author(s)
  Shimamoto Y, Hattori Y, Kobayashi K, Teruya K, Sanjho A, Nakagawa A, Yamashita E, Akaji K.
- Journal Title
  
  Bioorganic and Medicinal Chemistry
  
  Volume: 23 Issue: 4 Pages: 876-890
- DOI
  10.1016/j.bmc.2014.12.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K01804, KAKENHI-PROJECT-25460160
[Journal Article] Chemical Dynamic Kinetic Resolution and S/R Interconversion of Unprotected α-Amino Acids2014
- Author(s)
  Takeda, R.; Kawamura, A.; Kawashima, A.; Sato, T.; Moriwaki, H.; Izawa, K.; Akaji, K.; Wang, S.; Liu, H.; Acena, J. L.; Soloshonok, V. A.
- Journal Title
  
  Angew. Chem. Int. Ed.
  
  Volume: 53 Issue: 45 Pages: 12214-12217
- DOI
  10.1002/anie.201407944
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460160
[Journal Article] Synthesis of an O-acyl isopeptide by using native chemical ligation in an aqueous solvent system.2014
- Author(s)
  川島浩之
- Journal Title
  
  Journal of Peptide Science
  
  Volume: 20 Issue: 5 Pages: 361-365
- DOI
  10.1002/psc.2622
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J08493, KAKENHI-PROJECT-25460160
[Journal Article] Interaction of Thioflavin T with Amyloid Fibrils of Apolipoprotein A-I N-terminal Fragment: Resonance Energy Transfer Study.2014
- Author(s)
  Girych, M., Gorbenko, G., Trusova, V., Adachi, E., Mizuguchi, C., Nagao, K., Kawashima, H., Akaji, K., Lund-Katz, S., Phillips, M. C., and Saito, H.
- Journal Title
  
  J. Struct. Biol.
  
  Volume: 185 Issue: 1 Pages: 116-124
- DOI
  10.1016/j.jsb.2013.10.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293006, KAKENHI-PROJECT-25670014, KAKENHI-PROJECT-25850070
[Journal Article] The Extreme N-terminal Region of Human Apolipoprotein A-I Has a Strong Propensity to Form Amyloid Fibrils2014
- Author(s)
  Adachi, E., Kosaka, A., Tsuji, K., Mizuguchi, C., Kawashima, H., Shigenaga, A., Nagao, K., Akaji, K., Otaka, A., and Saito, H.
- Journal Title
  
  FEBS Lett.
  
  Volume: 588 Issue: 3 Pages: 389-394
- DOI
  10.1016/j.febslet.2013.11.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293006, KAKENHI-PROJECT-25670014, KAKENHI-PROJECT-25850070
[Journal Article] Effect of prome-site sequence of retro-inverso-modified HTLV-1 protease inhibitor.2014
- Author(s)
  Awahara, C.; Tatsumi, T.; Furuta, S.; Shinjoh, G.; Konno, H.; Nosaka, K.; Kobayashi, K.; Hattori, Y.; Akaji, K.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 22 Issue: 8 Pages: 2482-2488
- DOI
  10.1016/j.bmc.2014.02.050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25450145, KAKENHI-PROJECT-25460160
[Journal Article] Synthesis and evaluation of inhibitory activity of the curcumin derivatives toward the inhibitor of beta-site amyloid precursor protein cleaving enzyme 1.2014
- Author(s)
  Konno, H.; Endo, H.; Ise, S.; Miyazaki, K.; Aoki, H.; Sanjo, A.; Hattori, Y.; Akaji, K.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 24 Issue: 2 Pages: 685-690
- DOI
  10.1016/j.bmcl.2013.11.039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25450145, KAKENHI-PROJECT-25460160
[Journal Article] Dual role of an N-terminal amyloidogenic mutationin apolipoprotein A-I.2013
- Author(s)
  足立愛美
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 228 Issue: 4 Pages: 2848-2856
- DOI
  10.1074/jbc.m112.428052
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J08493, KAKENHI-PROJECT-22590046, KAKENHI-PROJECT-25293006
[Journal Article] Development of potent dipeptide-type SARS-CoV 3CL protease inhibitors with novel P3 scaffolds: Design, synthesis, biological evaluation, and docking studies2013
- Author(s)
  Thanigaimalai, P.; Konno, S.; Yamamoto, T.; Koiwai, Y.; Taguchi, A.; Takayama, K.; Yakushiji, F.; Akaji, K.; Chen, S.-E.;Naser-Tavakolian, A.; Schon, A.; Freire, E.; Hayashi, Y.
- Journal Title
  
  Eur. J. Med. Chem.
  
  Volume: 68 Pages: 372-384
- DOI
  10.1016/j.ejmech.2013.07.037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460160
[Journal Article] Effect of ring size and side-chain orientation of cyclic peptides for the inhibition of EGF receptor dimerization.2013
- Author(s)
  Takaaki Mizuguchi, Naho Ohara, Mika Iida, Ryunosuke Ninomiya, Shinji Wada, Yoshiaki Kiso, Kazuki Saito, Kenichi Akaji
- Journal Title
  
  Peptide Science
  
  Volume: 2012 Pages: 19-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590134
[Journal Article] Design, synthesis, and biological evaluation of novel dipeptide-type SARS-CoV 3CL protease inhibitors: Structure–activity relationship study2013
- Author(s)
  Pillaiyar Thanigaimalai
- Journal Title
  
  European Journal of Medicinal Chemistry
  
  Volume: in press Pages: 999-999
- DOI
  10.1016/j.ejmech.2013.05.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659059, KAKENHI-PROJECT-25460160
[Journal Article] Practical synthesis of peptide C-terminal aldehyde on a solid support2013
- Author(s)
  Konno, H.; Sema, Y.; Ishii, M.; Hattori, Y.; Nosaka, K.; Akaji, K.
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 54 Issue: 36 Pages: 4848-4850
- DOI
  10.1016/j.tetlet.2013.06.103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25450145, KAKENHI-PROJECT-25460160
[Journal Article] Design and synthesis of new tripeptide-type SARS-CoV 3CL protease inhibitors containing an electrophilic arylketone moiety2013
- Author(s)
  S. Konno, P. Thanigaimalai, Shen-En Chen, Ernesto Freire, Y. Hayashi, 他9名
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 21 Issue: 2 Pages: 412-424
- DOI
  10.1016/j.bmc.2012.11.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11F01104, KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-23659059, KAKENHI-PROJECT-25460160
[Journal Article] Evaluation of dimerization-inhibitory activities of cyclic peptides containing a β-hairpin loop sequence of the EGF receptor2012
- Author(s)
  Takaaki Mizuguchi, et al.
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 20 Issue: 19 Pages: 5730-5737
- DOI
  10.1016/j.bmc.2012.08.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J06748, KAKENHI-PROJECT-24590134
[Journal Article] Structure-based Design, Synthesis, and Evaluation of Peptide-mimetic SARS 3CL Protease Inhibitors2011
- Author(s)
  Akaji, K.; Konno, H.; Mitsui, H.; Teruya, K.; Shimamoto, Y.; Hattori, Y.; Ozaki, T.; Kusunoki, M.; Sanjoh, A
- Journal Title
  
  J. Med. Chem
  
  Volume: 54 Pages: 7962-7937
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590017
[Journal Article] Synthesis of Tokaramide A, a Cysteine Protease Inhibitor from Marine Sponge Theonella aff2011
- Author(s)
  Konno, H.; Nosaka, K.; Akaji, K
- Journal Title
  
  Mirabilis. Tetrahedron
  
  Volume: 67 Pages: 9067-9071
- Data Source
  KAKENHI-PROJECT-21590017
[Journal Article] Structure-Based Design, Synthesis, and Evaluation of Peptide-Mimetic SARS 3CL Protease Inhibitors2011
- Author(s)
  Kenichi. Akaji, et.al.
- Journal Title
  
  J.Med.Chem.
  
  Volume: 54 Issue: 23 Pages: 7962-7973
- DOI
  10.1021/jm200870n
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590017, KAKENHI-PROJECT-21689004, KAKENHI-PROJECT-23550195
[Journal Article] Evaluation of retero-inverso modification of HTLV-1 protease inhibitors containing a hydroxylethyl amine isoster2010
- Author(s)
  Tatsumi, T.; Awahara, C.; Naka, H.; Aimoto, S.; Konno, K.; Nosaka, K.; Akaji, K
- Journal Title
  
  Bioorg Med. Chem
  
  Volume: 18 Pages: 2720-2727
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590017
[Journal Article] Synthesis of solamin type mono-THF acetogenins using cross-methathesis2010
- Author(s)
  Konno, H.; Makabe, H.; Hattori, Y.; Nosaka, K.; Akaji, K
- Journal Title
  
  Tetrahedoron
  
  Volume: 66 Pages: 7946-7953
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590017
[Journal Article] Synthesis of solamin type mono-THF acetogenins using cross-methathesis2010
- Author(s)
  Konno, H.; Makabe, H.; Hattori, Y.; Nosaka, K.; Akaji, K
- Journal Title
  
  Tetrahedron
  
  Volume: 66 Pages: 7946-7953
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590017
[Journal Article] Synthetic studies on callipeltins : Stereoselective syntheses of(3S, 4R)-3, 4-Dimethyl-L-pyroglutamic acid and Fmoc-D-allothreonine from serine derivatives2010
- Author(s)
  Konno, K.; Takebayashi, Y.; Nosaka, K.; Akaji, K
- Journal Title
  
  Heterocycles
  
  Volume: 81 Pages: 79-89
- NAID
  40016913697
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590017
[Journal Article] Synthetic studies on callipeltins : Stereoselective syntheses of(3S,4R)-3,4-Dimethyl-L-pyroglutamic acid and Fmoc-D- allothreonine from serine derivatives2010
- Author(s)
  Konno, K.; Takebayashi, Y.; Nosaka, K.; Akaji, K
- Journal Title
  
  Heterocycles
  
  Volume: 81 Pages: 79-89
- NAID
  40016913697
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590017
[Journal Article] Evaluation of retero-inverso modification of HTLV-1 protease inhibitors containing a hydroxyethylamine isoster2010
- Author(s)
  Tatsumi, T.; Awahara, C.; Naka, H.; Aimoto, S.; Konno, K.; Nosaka, K.; Akaji, K
- Journal Title
  
  Bioorg.Med.Chem
  
  Volume: 18 Pages: 2720-2727
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590017
[Journal Article] Synthesis of [19,35,36-13C3]-labeled TAK779 as a Molecular Probe2009
- Author(s)
  Konno H, Aimoto S, Smith S.O, Nosaka K, Akaji K
- Journal Title
  
  Bioorg.Med.Chem 17
  
  Pages: 5769-5774
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590017
[Journal Article] Synthesis of [19, 35, 36-13C3]-labeled TAK779 as a Molecular Probe.2009
- Author(s)
  Konno H, ; Aimoto S, ; Smith SO, ; Nosaka K, ; Akaji K
- Journal Title
  
  Bioorg Med. Chem
  
  Volume: 17 Pages: 5769-5774
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590017
[Presentation] ペプチド化学を基盤とするプロテアーゼ阻害剤の設計・合成と評価2019
- Author(s)
  赤路健一
- Organizer
  日本農芸化学会2019年度大会 (東京)
- Invited
- Data Source
  KAKENHI-PROJECT-16H05104
[Presentation] Design and evaluation of functional molecules interacting with Epidermal Growth Factor Receptor (EGFR)2019
- Author(s)
  Kenichi Akaji
- Organizer
  2019 Research Day and International Conference at National Taiwan University
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05104
[Presentation] 新規相互作用部位を導入したデカヒドロイソキノリン型SARS 3CLプロテアーゼ阻害剤の設計と合成2018
- Author(s)
  大西康司、三谷勇人、嶋本康広、小林数也、服部恭尚、赤路健一
- Organizer
  日本薬学会第138年会 (金沢)
- Data Source
  KAKENHI-PROJECT-16H05104
[Presentation] Synthesis and evaluation of novel BACE1 inhibitors based on the N-amidino nitrogen-containing ring structure2018
- Author(s)
  Kazuya Kobayashi, Daiki Joho, Chinami Taniguchi, Misaki Tanaka, Rani Kimura, Kaho Komurasaki, Yuki Kawasaki, Yasunao Hattori, Kenichi Akaji
- Organizer
  256th ACS National Meeting & Exposition (Boston, USA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05104
[Presentation] オクタヒドロイソクロメン型SARS 3CLプロテアーゼ阻害剤の設計と評価2018
- Author(s)
  吉澤慎一郎、足尾真美、越野裕貴、山中優季、小林数也、服部恭尚、赤路健一:
- Organizer
  日本薬学会第138年会 (金沢)
- Data Source
  KAKENHI-PROJECT-16H05104
[Presentation] 大環状BACE1阻害剤の合成と活性評価2018
- Author(s)
  大谷拓也、小林数也、服部恭尚、赤路健一
- Organizer
  日本薬学会第138年会 (金沢)
- Data Source
  KAKENHI-PROJECT-16H05104
[Presentation] 新規相互作用部位を導入したオクタヒドロイソクロメン型SARS 3CLプロテアーゼ阻害剤の設計と合成2018
- Author(s)
  藤原采耶花、大西康司、吉澤慎一郎、濱本凪彩、小林数也、服部恭尚、赤路健一
- Organizer
  日本薬学会第138年会 (金沢)
- Data Source
  KAKENHI-PROJECT-16H05104
[Presentation] N-アミジノピペリジン型BACE1阻害剤の合成2017
- Author(s)
  城寳大輝、小林数也、服部恭尚、赤路健一
- Organizer
  日本薬学会第137年会 (仙台)
- Data Source
  KAKENHI-PROJECT-16H05104
[Presentation] デカヒドロイソキノリン骨格を基盤とする新規縮環型SARS 3CLprotease阻害剤の設計と合成2017
- Author(s)
  大西康司、嶋本康広、小林数也、服部恭尚、照屋健太、赤路健一
- Organizer
  日本薬学会第137年会 (仙台)
- Data Source
  KAKENHI-PROJECT-16H05104
[Presentation] オクタヒドロイソクロメン骨格を有するSARS 3CLプロテアーゼ阻害剤の合成研究2017
- Author(s)
  越野裕貴、吉澤慎一郎、足尾真美、山中優季、山本侑人、小林数也、服部恭尚、赤路健一
- Organizer
  第67回日本薬学会近畿支部総会・大会 (兵庫)
- Data Source
  KAKENHI-PROJECT-16H05104
[Presentation] N-アミジノ含窒素環状骨格を基盤とするBACE1阻害剤の探索研究2017
- Author(s)
  小林数也、城寳大輝、谷口智奈美、田中美咲、木村蘭希、川崎友紀、服部恭尚、赤路健一
- Organizer
  第43回反応と合成の進歩シンポジウム (富山)
- Data Source
  KAKENHI-PROJECT-16H05104
[Presentation] N-アミジノピペリジン型BACE1阻害剤の合成2017
- Author(s)
  城寳大輝、小林数也、服部恭尚、赤路健一
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K18902
[Presentation] オクタヒドロイソクロメン骨格を基盤とする縮環型SARS 3CLプロテアーゼ阻害剤の合成2017
- Author(s)
  吉澤慎一郎、足尾真美、越野裕貴、山中優季、小林数也、服部恭尚、赤路健一
- Organizer
  日本薬学会第137年会 (仙台)
- Data Source
  KAKENHI-PROJECT-16H05104
[Presentation] Effect of heparin on amyloid fibril formation of apoA-I fragment peptides2016
- Author(s)
  Shiho Mikawa, Chiharu Mizuguchi, Izumi Morita, Hiroyuki Oyama, Teruhiko Baba, Akira Shigenaga, Toshinori Shimanouchi, Norihiro Kobayashi, Akira Otaka, Kenichi Akaji, and Hiroyuki Saito
- Organizer
  第53回ペプチド討論会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-25293006
[Presentation] オクタヒドロイソクロメン骨格構築を基盤とする縮環型SARS 3CLプロテアーゼ阻害剤の合成2016
- Author(s)
  吉澤慎一郎、服部恭尚、小林数也、大西康司、足尾真美、越野裕貴、山中優季、赤路健一
- Organizer
  第42回反応と合成の進歩シンポジウム
- Place of Presentation
  静岡市、清水文化会館マリナート
- Year and Date
  2016-11-07
- Data Source
  KAKENHI-PROJECT-16H05104
[Presentation] Structure Activity Relationship Study for P1-P1’ Site of Transition State Mimic Inhibitors for BACE12016
- Author(s)
  Kazuya Kobayashi, Yasunao Hattori, Kenta Teruya, Akira Sanjoh, Atsushi Nakagawa, Eiki Yamashita, Kenichi Akaji
- Organizer
  34th European Peptide Symposium/8th International Peptide Symposium
- Place of Presentation
  Leipzig, Germany
- Year and Date
  2016-09-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05104
[Presentation] デカヒドロイソキノリン骨格を基盤とする新規縮環型SARS 3CLプロテアーゼ阻害剤の設計・合成と複合体解析2016
- Author(s)
  大西康司、服部恭尚、小林数也、嶋本康広、照屋健太、三城明、赤路健一
- Organizer
  第46回複素環化学討論会
- Place of Presentation
  金沢市、金沢歌劇座
- Year and Date
  2016-09-26
- Data Source
  KAKENHI-PROJECT-16H05104
[Presentation] Synthesis and Evaluation of Substrate-based BACE1 Inhibitors2016
- Author(s)
  Kazuya Kobayashi, Yasunao Hattori, Ayaka Deguchi, Yukie Nohara, Tomomi Akiyama, Kenta Teruya, Akira Sanjoh, Athsushi Nakagawa, Eiki Yamashita, Kenichi Akaji
- Organizer
  20th Korean Peptide Protein Society Symposium
- Place of Presentation
  Yangyang, Korea
- Year and Date
  2016-06-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05104
[Presentation] Studies on cyclic peptides for the development of potent dimerization inhibitors against the EGF receptor2016
- Author(s)
  Takaaki Mizuguchi, Kei Toyama, Wataru Nomura, Kenichi Akaji, Hirokazu Tamamura
- Organizer
  The 8th Takeda Science Foundation Symposium on PharmaSciences
- Place of Presentation
  Center for Learning and Innovation Takeda Pharmaceutical Company, Ltd.
- Year and Date
  2016-01-21
- Data Source
  KAKENHI-PROJECT-26893061
[Presentation] HEA型BACE1阻害剤の構造最適化を目指した合成法の開拓2016
- Author(s)
  小林数也、出口綾香、菊池真理、井尻咲、服部恭尚、赤路健一
- Organizer
  第66回日本薬学会近畿支部大会
- Place of Presentation
  大阪府高槻市、大阪薬科大学
- Year and Date
  2016-10-15
- Data Source
  KAKENHI-PROJECT-16H05104
[Presentation] Evaluation of Hydroxymethylcarbonyl and Hydroxyethylamine Isosteres in a Superior BACE1 Cleavage Sequence for BACE1 Inhibitors2015
- Author(s)
  Kazuya Kobayashi, Yasunao Hattori, Ayaka Deguchi, Yukie Nohara, Tomomi Akiyama, Kenta Teruya, Akira Sanjoh, Atsushi Nakagawa, Eiki Yamashita, Kenichi Akaji
- Organizer
  7th International Peptide Symposium
- Place of Presentation
  Singapore
- Year and Date
  2015-12-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460160
[Presentation] EGFレセプター二量化阻害環状ペプチドの活性部位に関する研究2014
- Author(s)
  水口貴章, 山﨑由香子, 小林数也, 大江保奈美, 飯田美佳, 二宮龍之介, 齋藤一樹, 赤路健一, 玉村啓和
- Organizer
  第51回ペプチド討論会
- Place of Presentation
  徳島大学蔵本キャンパス大塚講堂（徳島県徳島市）
- Year and Date
  2014-10-23
- Data Source
  KAKENHI-PROJECT-24590134
[Presentation] ヒドロキシエチルアミン型BACE1阻害剤の立体選択的合成によるプライムサイト構造活性相関研究2014
- Author(s)
  川崎友紀、松原弘樹、井尻咲、宮城崇滉、出口綾香、小林数也、服部恭尚、赤路健一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25860093
[Presentation] 二量体化に着目した新規作用機序のEGFレセプター阻害薬研究2014
- Author(s)
  水口貴章, 二宮龍之介, 飯田美佳, 大江保奈美, 山崎由香子, 小林数也, 齋藤一樹, 赤路健一, 玉村啓和
- Organizer
  創薬懇話会2014
- Place of Presentation
  長良川温泉ホテルパーク（岐阜県岐阜市）
- Year and Date
  2014-07-10
- Data Source
  KAKENHI-PROJECT-24590134
[Presentation] フラグメントペプチドを用いたアポA-Iアミロイド線維形成領域の同定2014
- Author(s)
  足立愛美，辻耕平，川島浩之，重永章，長尾耕治郎，赤路健一，大高章，斎藤博幸
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市総合体育館（熊本県）
- Data Source
  KAKENHI-PROJECT-25293006
[Presentation] アミロイドーシス変異アポA-Iの線維形成に及ぼす脂質膜の影響2013
- Author(s)
  水口智晴，足立愛美，川島浩之，長尾耕治郎，赤路健一，斎藤博幸
- Organizer
  第35回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  東京大学薬学部（東京都）
- Data Source
  KAKENHI-PROJECT-25293006
[Presentation] 脂質膜環境下でのアポA-Iアミロイド線維形成2013
- Author(s)
  水口智晴，足立愛美，川島浩之，長尾耕治郎，赤路健一，斎藤博幸
- Organizer
  日本膜学会第35年会
- Place of Presentation
  早稲田大学西早稲田キャンパス（東京都）
- Data Source
  KAKENHI-PROJECT-25293006
[Presentation] Design, synthesis, and evaluation of tripeptidemimetics with aryl ketone as inhibitors of SARS-COV 3CL protease2011
- Author(s)
  Kenichi Akaji, et.al.
- Organizer
  48^<th> Japanese peptide symposium
- Place of Presentation
  札幌コンベンションセンター(札幌市)
- Year and Date
  2011-09-28
- Data Source
  KAKENHI-PROJECT-21590017
[Presentation] Evaluation of substrate specificities for BACE 1 using synthetic peptide libraries2010
- Author(s)
  T Kakizawa, Y Hattrori, K Teruya, A Sanjoh2, K Akaji
- Organizer
  第5回国際ペプチドシンポジウム
- Place of Presentation
  京都国際会議場
- Year and Date
  2010-12-05
- Data Source
  KAKENHI-PROJECT-21590017
[Presentation] SARS 3CLプロテアーゼ阻害剤創成を目指したペプチドアルデヒドの合成と阻害能評価2010
- Author(s)
  今野博行、石井学、服部恭尚、野坂和人、赤路健一
- Organizer
  日本農芸化学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21590017
[Presentation] Synthesis and Evaluation of Small PeptideInhibitors for SARS 3CL Protease2010
- Author(s)
  Hiroyuki Konno, Manabu Ishii, Yasunao Hattori, Kazuto Nosaka, Kenichi Akaji
- Organizer
  5th International Peptide Symposium
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-21590017
[Presentation] 構造解析に基づくSARS 3CL Protease阻害剤の設計とその阻害能評価2010
- Author(s)
  今野博行、石井学、野坂和人、服部恭尚、赤路健一
- Organizer
  東北支部第145回大会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-21590017
[Presentation] Design of small molecular inhibitor for SARS 3CL protease besed on structure analysis2009
- Author(s)
  Akaji K, Nosaka K, Hattori Y, Mitsui H, Konno H, Kusunoki M, Ozaki T, Sanjo A
- Organizer
  第46回ペプチド討論会
- Place of Presentation
  北九州
- Year and Date
  2009-11-04
- Data Source
  KAKENHI-PROJECT-21590017
[Presentation] SARS 3CLプロテアーゼ阻害に必要なチオール反応性官能基の評価2009
- Author(s)
  三井寛法、高橋麻矢子、今野博行、野坂和人、赤路健一
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-21590017
[Presentation] 固相法によるペプチドアルデヒド類の実践的合成法の検討2009
- Author(s)
  今野博行、石井学、服部恭尚、野坂和人、赤路健一
- Organizer
  第46回ペプチド討論会
- Place of Presentation
  北九州
- Year and Date
  2009-11-04
- Data Source
  KAKENHI-PROJECT-21590017
[Presentation] 構造解析に基づくペプチドアルデヒド型SARS 3CLプロテアーゼ阻害剤の合成と評価2009
- Author(s)
  今野博行、野坂和人、小野塚真理、三井寛典、赤路健一、楠木正巳、尾崎健、三城明
- Organizer
  第35回反応と合成の進歩シンポジウム
- Place of Presentation
  金沢
- Year and Date
  2009-11-16
- Data Source
  KAKENHI-PROJECT-21590017
[Presentation] ヒドロキシエチルアミン型BACE1阻害剤の活性立体配置の同定とプライムサイト構造活性相関研究
- Author(s)
  井尻咲、松原弘樹、川崎友紀、宮城崇滉、出口綾香、小林数也、服部恭尚、赤路健一
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25860093
[Presentation] EGFレセプターの二量化阻害ペプチドをもとにしたアラニン置換ペプチドの細胞増殖抑制効果
- Author(s)
  二宮龍之介, 水口貴章, 大原菜穂, 飯田美佳, 齋藤一樹, 赤路健一
- Organizer
  第62回日本薬学会近畿支部総会・大会
- Place of Presentation
  武庫川女子大学浜甲子園キャンパス（西宮市）
- Data Source
  KAKENHI-PROJECT-24590134
[Presentation] EGFレセプターの二量化阻害に必要な環状ペプチドの環の大きさと側鎖配置の効果
- Author(s)
  水口貴章, 大原菜穂, 飯田美佳, 二宮龍之介, 和田真治, 木曽良明, 齋藤一樹, 赤路健一
- Organizer
  第49回ペプチド討論会
- Place of Presentation
  かごしま県民交流センター（鹿児島市）
- Data Source
  KAKENHI-PROJECT-24590134
[Presentation] EGFレセプターの二量化阻害活性を示す環状ペプチドの環サイズと側鎖配置の評価
- Author(s)
  大原菜穂, 水口貴章, 二宮龍之介, 飯田美佳, 齋藤一樹, 赤路健一
- Organizer
  第62回日本薬学会近畿支部総会・大会
- Place of Presentation
  武庫川女子大学浜甲子園キャンパス（西宮市）
- Data Source
  KAKENHI-PROJECT-24590134
[Presentation] ヒドロキシエチルアミン型BACE1阻害剤の立体選択的合成と活性評価
- Author(s)
  松原弘樹、井尻咲、川崎友紀、宮城崇滉、出口綾香、小林数也、服部恭尚、赤路健一
- Organizer
  第63回日本薬学会近畿支部総会・大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25860093
[Presentation] EGFレセプターの二量化阻害を示す環状ペプチドの構造的特徴
- Author(s)
  水口貴章, 大原菜穂, 二宮龍之介, 山崎由香子, 飯田美佳, 大江保奈美, 齋藤一樹, 赤路健一
- Organizer
  日本薬学会第133回年会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-24590134
[Presentation] Dアミノ酸を利用した阻害剤設計
- Author(s)
  赤路健一
- Organizer
  2014年度創薬科学フロンティアシンポジウム
- Place of Presentation
  京都
- Year and Date
  2014-11-22 – 2014-11-23
- Data Source
  KAKENHI-PROJECT-25460160
[Presentation] プロテアーゼの基質認識に基づく阻害剤設計
- Author(s)
  赤路健一
- Organizer
  第19回ペプチドフォーラム
- Place of Presentation
  山形大学工学部百周年記念会館（山形県米沢市）
- Invited
- Data Source
  KAKENHI-PROJECT-25460160

1. KISO Yoshiaki (40089107)

# of Collaborated Projects: 19 results

# of Collaborated Products: 0 results
2. KIMURA Tooru (70204980)

# of Collaborated Projects: 18 results

# of Collaborated Products: 0 results
3. FUJIWARA Yoichi (60199396)

# of Collaborated Projects: 16 results

# of Collaborated Products: 0 results
4. HATTORI Yasunao (20567028)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
5. FUNAKOSHI Susumu (10135593)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. NOSAKA Kazuto (10228314)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
7. KONNO Hiroyuki (50325247)

# of Collaborated Projects: 2 results

# of Collaborated Products: 21 results
8. MIZUGUCHI Takaaki (30732557)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
9. KOBAYASHI Kazuya (80647868)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
10. KOBAYASHI Yuji (20127228)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. YARCHOAN Robert

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. MITSUYA Hiroaki

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. YAMAZAKI Toshimasa

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. SAITO Kazuki (10192585)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. TAKADA Kanji (30102106)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. KAWAKAMI Toru (70273711)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. YAJIMA Haruaki (00025678)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. FUJII Nobutaka (60109014)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. TAMAMURA Hirokazu (80217182)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
20. NOMURA Wataru (80463909)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. Saito Hiroyuki (60300919)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
22. OTAKA Akira (20201973)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. OKAMURA Emiko (00160705)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. KOBAYASHI Norihiro (90205477)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
25. KITAGAWA Shuji (00108911)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. MICHIKAWA Makoto (40270912)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 笠原二郎 (10295131)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 長尾耕治郎 (40587325)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
29. DEGUCHI Ayaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
30. HAYASHI Yoshio

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. TOYAMA Kei

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
32. 木曾良明

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. ROBERT Yarch

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. USSERY Micha

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. TORCHIA Denn

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 三本勤

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. UCHIMURA Kenji

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
38. 大野浩章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 大石真也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 大高章

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
41. 斎藤一樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 8 results
42. 川島浩之

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
43. 照屋健太

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Akaji Kenichi 赤路 健一

AKAJI Kenichi 赤路 健一

赤路 健一 アカジ ケンイチ

Research Projects

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Co-Researchers

Strategies for transformation of a substrate-based protease inhibitor to non-peptide inhibitorPrincipal Investigator

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Design of non-peptide inhibitors based on structure analyses of the protease/inhibitor complexPrincipal Investigator

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Development of a novel persistent protease inhibitor containing D-amino acidPrincipal Investigator

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Development of SARS virus inhibitor using unusual amino acid-containing natural products as seedsPrincipal Investigator

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Combinatorial Synthesis of Transition State Mimetic Inhibitor Using Asymmetric Aldol, ReactionPrincipal Investigator

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Intramolecularcyclization by solid-phase olefination and its application to combinatorial synthesisPrincipal Investigator

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Convergent synthesis and SAR of dolastatin 15 by solid phase couplingPrincipal Investigator

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Akaji Kenichi 赤路健一

AKAJI Kenichi 赤路健一

赤路健一アカジケンイチ