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NAKASHIMA Shigeru  中島 茂

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… Alternative Names

中島 茂  ナカシマ シゲル

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Researcher Number 60188935
Other IDs
External Links
Affiliation (based on the past Project Information) *help 1999 – 2003: Gifu University, School of medicine, Department of Biochemistry, Professor, 医学部, 教授
1997 – 1998: Gifu University, School of Medicine, Department of Biochemistry, Associate Professor, 医学部, 助教授
1994 – 1996: 岐阜大学, 医学部, 講師
1995: 岐阜大学, 医学部・生化学, 講師
1990: 岐阜大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Cell biology / Pathological medical chemistry / General medical chemistry / Surgical dentistry
Except Principal Investigator
Cerebral neurosurgery / Functional biochemistry / Pathological medical chemistry / Biological Sciences / 代謝生物化学
Keywords
Principal Investigator
ホスホリパーゼD / チロシンキナーゼ / phospholipase D / プロテインキナーゼC / protein tyrosine kinase / cDNA / differentiation / apoptosis / RhoA / 細胞分化 … More / アポトーシス / protein kinase C / MAPキナーゼ / PC12細胞 / gene knockout / cell-specific expression / phospholipase D superfamily / pld-1 gene / Caenorhabditis elegans / SL-1 / GFP / 遺伝子破壊 / 体内局在 / ホスホリパーゼD類縁遺伝子 / 遺伝子 / 線虫 / oxygen stress / ceramide / PLDOA / PLD1 / 酵素ストレス / 酸化ストレス / 酸素ストレス / セラミド / PLD_<OA> / PLDI / transcription factor / growth factor / クロストリジウムトキシンB / 転写因子 / 増殖因子 / Rho A / phospholipase C / prostaglandins / osteoblast cells / Cキナーゼ / ホスファチジン酸 / ジアシルグリセロール / プロスタグランジンFSα / プロスタグランシン / ホスホリパーゼC / プロスタグランジン / 骨芽細胞 / C6細胞 / 神経分泌 / GTP結合タンパク質 / カルシウム / ホスホリペ-ゼD … More
Except Principal Investigator
ホスホリパーゼD / アポトーシス / 分化 / ホスホリパーゼC / AKT / SPHINGOSINE 1-PHOSPHATE / PHOSPHOLIPASE D / ERK / スフィンゴシン1-リン酸 / apoptosis / 血小板 / セラミド / 増殖 / p53 / cAMP / caspase / PHOSPHATIDYLINOSITOL 3-KINASE / Akt / hypoxia / mRNA / セリンプロテアーゼ / r-gsp / Phospholipase C / Human platelet / IIIa / インテグリンGPIIb / ヒト血小板 / Apoptosis / Phospholipase D / CPP32 / 情報変換酵素 / 情報伝達 / チロシンキナーゼ / 遺伝子クローニング / 細胞骨格 / シグナル伝達機構 / 細胞増殖 / 分化誘導 / SURVIVAL SIGNALING / 膜脂質変換酵素 / 生存シグナル / PI3-キナーゼ / radiation / glima / caspase-3 / ヒト悪性膠腫 / 放射線 / グリオーマ / complement C1s / S100 protein / serine protease / glial differentiation / C6 glioma cells / リポフェクション / スタウロスポリン / サイクリックAMP / グリオーマ細胞 / S100タンパク質 / 補体C1s / 分泌型セリンプロテアーゼ / C6グリオーマ細胞 / EDG3 / PHOSPHATIDYLINOSITOL3-KINASE / PHINGOSINE KINASE / スフィンゴシンキナーゼ / reactive oxygen species / sphingomyelinase / ceramide / Bcl-2 family / phospholipase D / 低酸素刺激 / 虚血性脳血管障害 / Bcl-2 / スフィンゴミエリナーゼ / カスパーゼ / ネクローシス / 活性酸素 / SURVAIVAL / 老化 / 分泌応答 / 細胞機能解析 / 遺伝子導入 / P38MAPK / H_2O_2 / 癌化 / PI3キナーゼ / 抗アポトーシス作用 / PC12 cell / ischemia / tissue plasminogen activator / Serin protease / 海馬 / C6 / グリア / PLD / プロテアーゼ / 虚血 / 脳修復 / グリア細胞 / tPA / 低酸素 / 脳虚血 / Gbetagamma subunit / Integrin signaling / 接着 / チロシンリン酸化 / PI-PLC / G蛋白βγサブユニット / インテグリンシグナリング / Proliferation / Cell function / Molecular cloning / チロシンキナ-ザ / ホスホリバーゼD / 細胞機能 / Aggregation / Cytoskeleton / Intergin alpha_<IIb>beta_3 / ホスホリパーゼc / 凝集 / C6 cells / C2 ceramide / Signal transduction / ホスホリパーゼ / C6細胞 / C2セラミド / 情報変換系 / Signaltransduction / GTP-binding protein / Phosphatidylinositol-phospholipase C / Human Platelets / 分子多様性 / GTP結合蛋白質 / ホスホリパ-ゼC / Gタンパク質 / メディエーター / スフィンゴ脂質 / 白血病 / セラミド結合蛋白 / ATMキナーゼ / PI-3キナーゼ / SM合成遺伝子 / SM合成酵素 / C6・細胞 / PC12細胞 / MAPキナーゼ / NGF / 細胞増殖抑制 / リン脂質 / フォスファターゼ / リン酸化ペプチド抗体 / アダプター蛋白質 / 細胞内シグナル伝達 / 細胞ガン化 / small GTP結合蛋白質Rho / 細胞骨格リン酸化 / キナーゼ / ホスファターゼ / ストレス依存性シグナル伝達 / 膜リン脂質 / Crk / MAPKホスファターゼ / 表皮細胞 / GQ1b / ガングリオシド Less
  • Research Projects

    (23 results)
  • Co-Researchers

    (26 People)
  •  p53-Independent ceramide formation in human glioma cells during gamma-radiation-induced apoptosis.

    • Principal Investigator
      IWAMA Toru
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      GIFU UNIVERSITY
  •  REGULATORY MECHANISM OF PHOSPHOLIPASE D IN CELL GROWTH AND SURVIVAL SIGNALING

    • Principal Investigator
      BANNO Yoshiko
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional biochemistry
    • Research Institution
      GIFU UNIVERSITY
  •  Increased expression and secretion of r-Gsp protein, rat counterpart of complement C1s precursor during differentiation in rat C6 glioma cells

    • Principal Investigator
      SHINODA Jun
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      GIFU UNIVERSITY
  •  セラミド・シグナル調節による細胞死誘導機構の解明とその臨床的意義

    • Principal Investigator
      岡崎 俊朗
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tottori University
      Kyoto University
  •  MECHANISM OF PRODUCTION OF SUPHINGOSINE 1-PHOSPHATE AND SIGNAL TRANSDUCTION VIA ITS RECEPTOR

    • Principal Investigator
      BANNO Yoshiko
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional biochemistry
    • Research Institution
      GIFU UNIVERSITY
  •  Functional analysis of phospholipase D (PLD) superfamily in Caenorhabditis elegansPrincipal Investigator

    • Principal Investigator
      NAKASHIMA Shigeru
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cell biology
    • Research Institution
      Gifu University
  •  Analysis of signal transduction during ceramide-mediated apoptotic pathway in hypoxic PC12 cell death

    • Principal Investigator
      SAKAI Noboru
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      GIFU UNIVERSITY
  •  NGF誘起神経突起伸長におけるコリン燐脂質代謝亢進の分子機構

    • Principal Investigator
      野澤 義則
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Gifu University
  •  Functional analysis of the new signal transduction enzyme PLD by the molecular genetic technique

    • Principal Investigator
      NOZAWA Yoshinori
    • Project Period (FY)
      1998 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (B)
    • Review Section
      Biological Sciences
    • Research Institution
      INSTITUTE OF APPLIED BIOCHEMISTRY
      Gifu University
  •  Roles of a new signal transducing enzyme, phospholipase D (PLD) during cellular apoptosisPrincipal Investigator

    • Principal Investigator
      NAKASHIMA Shigeru
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Gifu University
  •  NGF誘起神経突起伸長におけるコリン燐脂質代謝亢進の分子機構

    • Principal Investigator
      野澤 義則
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Gifu University
  •  Molecular mechanisms for regulation and physiological role of phospholipase D

    • Principal Investigator
      NOZAWA Yoshinori
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      GIFU UNIVERSITY
  •  Studies on integtin signaling in platelet adhesion and aggregation

    • Principal Investigator
      BANNO Yoshiko
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      GIFU UNIVERSYTI
  •  Estimation of serine protease mRNA in glial cells after ischemic and hypoxic conditions.

    • Principal Investigator
      ANDOH Takashi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      ASAHI UNIVERSITY
      Gifu University
  •  NGF誘起神経突起伸長におけるコリン燐脂質代謝抗進の分子メカニズムPrincipal Investigator

    • Principal Investigator
      中島 茂
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Gifu University
  •  Regulatory mechanisms and roles of phospholipase D (PLD) in cellular responsesPrincipal Investigator

    • Principal Investigator
      NAKASHIMA Shigeru
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Gifu University
  •  シグナル伝達機構による細胞増殖制御

    • Principal Investigator
      稲垣 昌樹
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Aichi Cancer Center Research Institute
      Tokyo Metropolitan Institute of Gerontology
  •  NGF誘起神経突起伸長におけるコリン燐脂質代謝亢進の分子メカニズムPrincipal Investigator

    • Principal Investigator
      中島 茂
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Gifu University
  •  Molecular mechanisms for membrane lipid signaling in apoptosis

    • Principal Investigator
      NOZAWA Yoshinori
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      GIFU UNIVERSITY
  •  Studies on integrin signaling in human platelets

    • Principal Investigator
      BANNO Yoshiko
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      GIFU UNIVERSITY
  •  Cellular signal transduction system in prostaglandin-stimulated osteoblast-like MC3T3-E1 cells : Phospholipid turnover and protein tyrosine phosphorylationPrincipal Investigator

    • Principal Investigator
      NAKASHIMA Shigeru
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Gifu University
  •  ガングリオシドGQ1bによる表皮細胞の分化誘導機構

    • Principal Investigator
      NOZAWA Yoshinori
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Gifu University
  •  Interaction of multiple phospholipase C and GTP-binding proteins in platelet signal transduction

    • Principal Investigator
      NOZAWA Yoshinori
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      代謝生物化学
    • Research Institution
      Gifu University
  • 1.  BANNO Yoshiko (50116852)
    # of Collaborated Projects: 17 results
    # of Collaborated Products: 0 results
  • 2.  NOZAWA Yoshinori (10021362)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 0 results
  • 3.  YOSHIMURA Shin-ichi (40240353)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  SAKAI Noboru (10021487)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  SHINODA Jun (50273131)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  KANAHO Yasunori (00214437)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  OKANO Yukio (10177066)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  KAKU Yasuhiko (90242718)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  IWAMA Toru (20303498)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  OKA Nobumitsu (80019893)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  ANDOH Takashi (90126722)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  DEGUCHI Kazuki (60217445)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  TAKENAKA Katsunobu (00283292)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  YAMADA Mikito (40308672)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  KUBOTA Yoshinori (60278207)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  TANAKA Masashi (60155166)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  AKAO Yukihiro (00222505)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  HISAMOTO Naoki (80283456)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  稲垣 昌樹 (30183007)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  渡辺 裕 (40114722)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  田村 眞理 (20124604)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  菊池 九二三 (20006117)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  千田 和広 (00192188)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  尾崎 庄一郎 (80145060)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  岡崎 俊朗 (40233308)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  山川 弘保 (80291392)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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