MATSUBARA Shyuichiro 松原修一郎

… Alternative Names

Matsubara Shyichiro 松原修一郎

MATSUBARA Shuichiro 松原修一郎

松原修一郎マツバラシユウイチロウ

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Researcher Number	60199841
Other IDs
Affiliation (Current)	2025: 鹿児島大学, 医学部, 客員研究員
Affiliation (based on the past Project Information) *help	2022 – 2023: 鹿児島大学, 医学部, 客員研究員 2021: 鹿児島大学, 医歯学総合研究科, 客員研究員 2020: 鹿児島大学, 医歯学総合研究科医学系, 客員研究員 2018 – 2019: 鹿児島大学, 総合科学域総合研究学系, 准教授 2014 – 2017: 鹿児島大学, 医用ミニブタ・先端医療開発研究センター, 准教授 … More 2015: 鹿児島大学, 医用ミニブタ先端医療開発研究センター, 准教授 2006 – 2009: Kagoshima University, Frontier Science Research Center, Associate Professor 2005 – 2006: 鹿児島大学, フロンティアサイエンス研究推進センター, 助教授 2005: Kagoshima University, Frontier Science Research Center, Associate Professor, フロンテイアサイエンス研究推進センター, 助教授 2004: 鹿児島大学, 生命科学資源開発研究センター, 助教授 1992: 鹿児島大学, 医学部, 助手 1988 – 1989: 鹿児島大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Cell biology / Digestive surgery / General surgery Except Principal Investigator Laboratory animal science / 物質生物化学 / Digestive surgery / Biomedical engineering/Biological material science
Keywords	Principal Investigator mTOR / シグナル伝達 / microRNA / 膵臓癌 / 癌幹細胞 / CD133 / 繊維化 / マクロピノサイトーシス / KRAS / エクソゾーム … More / CD13 / Akt / nTOR / cell cycle regulators / multicellular spheroids / signal transduction / cell-cell adhesion / compaction / proliferation / cadherin / α-catenin / タンパク質リン酸化 / 足場非依存性増殖 / がん化 / 細胞内シグナル伝達 / 細胞接着 / カテニン / 浮游培養 / リン酸化 / p120 / 増殖制御因子 / スフェロイド / コンパクション / 増殖抑制 / 細胞間接着 / カドヘリン / α-カテニン / miRNA / Hedgehog / 膵癌幹細胞 / mTOR複合体 / EMT / HIF-1alpha / miR-30 / HIF-1 / Slug / 上皮間葉転換 (EMT) / マイクロRNA / 移植外科学 / 大型実験動物 / 医用ミニブタ … More Except Principal Investigator レチノイン酸 / 異種移植 / テラトカルシノーマ / ヘパリン / 成長因子 / Biohazard / Clawn miniature swine / PERV / Xenotransplantation / 安全性 / 医用ミニブタ / 内在性レトロウイルス / Wilms'tumor / Arzheimer disease / Syndecan / retinoic acid receptor / neurotrophic factor / Growth factor / MK gene / Midkine / ヒト癌 / MK / ウィルムス腫瘍 / アルツハイマー病 / シンデカン / レチノイン酸レセプター / 神経栄養因子 / MK遺伝子 / ミッドカイン / cDNAクローニング / 転写制御 / in situハイブリダイゼンション / 分化因子 / マウス発生 / 細胞分化 / ヒト化抗FRαβ抗体 / CD68マクロファージ / FRβマクロファージ / caerulein誘導慢性膵炎 / miRNA / N-cadherin / EMT / nude mouse / fibrotic stroma / FRb receptor / migration / invasion / microRNA / FRbeta / miR-30 / tumor microenvironment / FRb-receptor / macrophage / CD133 / cancer stem cell / pancreatic cancer / α-1,3-ガラクトース転移酸素 / 樹状細胞 / gene targeting / 内在性レトロウイルス(PERV) / α-1,3-ガラクトース転移酵素 / 制御性T細胞 / HMGB-1 / ブタ内在性レトロウイルス(PERV) / 転移酵素 / α-1,3-ガラクトース / クローンミニブタ / クラウン系ミニブタ / 脱がん / 胚発生 / 胚性腫瘍細胞 / 分化誘導 Less

Research on targeted therapy of pancreatic cancer stem cells using exosomesPrincipal Investigator
- Principal Investigator
  
  MATSUBARA Shyuichiro
- Project Period (FY)
  2018 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kagoshima University
CD133 dependent signals and microRNAs in cancer stem cellsPrincipal Investigator
- Principal Investigator
  
  MATSUBARA Shyuichiro
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kagoshima University
Analysis of the interaction between the folate receptor beta expression macrophages and cancer stem cells in pancreatic cancer invasion
- Principal Investigator
  
  TAKAO SONSHIN
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kagoshima University
Basic studies to produce genetically modified swine cells as the donor for nuclear-transferPrincipal Investigator
- Principal Investigator
  
  MATSUBARA Shyuichiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Kagoshima University
A fundamental study on xenotransplantation
- Principal Investigator
  
  TAKAO Sonshin
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Kagoshima University
Study on Safety of Xenotransplantation: Characterization of Porcine Endogenous Retrovirus of Clawn Miniature Swine
- Principal Investigator
  
  FUJIYOSHI Toshinobu
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Kagoshima University
Signal transduction from α-catenin and the mechanism of growth suppression dependent on cell-cell adhesion.Principal Investigator
- Principal Investigator
  
  MATSUBARA Shyuichiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Kagoshima University
Studies on a new growth factor under the control of retinoic acid, midkine (MK)
- Principal Investigator
  
  MURAMATSU Takashi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  物質生物化学
- Research Institution
  Nagoya University School of Medicine
  Kagoshima University
レチノイン酸による分化脱がん時に初期応答する遺伝子群の解析
- Principal Investigator
  
  MURAMATSU Takashi
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kagoshima University
テラトカルシノーマの分化方向決定に関連する遺伝子の転写制御と機能
- Principal Investigator
  
  村松喬
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kagoshima University

All 2020 2019 2018 2017 2016 2015 2014 2013 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation

[Journal Article] Prevention of Akt phosphorylation is a key to targeting cancer stem-like cells by mTOR inhibition2020
- Author(s)
  Shyuichiro Matsubara, Koichiro Tsukasa, Taisaku Kuwahata, Sonshin Takao
- Journal Title
  
  Human cell
  
  Volume: 33 Issue: 4 Pages: 1197-1203
- DOI
  10.1007/s13577-020-00416-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08627
[Journal Article] Efficient elimination of pancreatic cancer stem cells by Hedgehog/GLI inhibitor GANT61 in combination with mTOR inhibition.2016
- Author(s)
  Miyazaki Y, Matsubara S, Qiang Ding, Tsukasa K, Yoshimitsu M, Kosai K, Takao S.
- Journal Title
  
  Molecular Cancer
  
  Volume: 10 Issue: 1 Pages: 49-49
- DOI
  10.1186/s12943-016-0534-2
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293234, KAKENHI-PROJECT-26462069
[Journal Article] miR-30 family promotes migratory and invasive abilities in CD133+ pancreatic cancer stem-like cells.2016
- Author(s)
  Tsukasa K, Ding Q, Miyazaki Y, Matsubara S, Natsugoe S, Takao S.
- Journal Title
  
  Hum Cell
  
  Volume: 0 Pages: 0-0
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293288
[Journal Article] miR-30 family promotes migratory and invasive abilities in CD133+ pancreatic cancer stem-like cells.2016
- Author(s)
  Tsukasa K, Ding Q, Miyazaki 1, Matsubara S, Natsugoe S, Takao S
- Journal Title
  
  Hum Cell
  
  Volume: 28 Issue: 3 Pages: 1-8
- DOI
  10.1007/s13577-016-0137-7
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462069
[Journal Article] CD133 facilitates epithelial-mesenchymal transition through interaction with the ERK pathway in pancreatic cancer metastasis.2014
- Author(s)
  Ding Q, Miyazaki Y, Tsukasa K, Matsubara S, Yoshimitsu M, Takao S.
- Journal Title
  
  Molecular Cancer
  
  Volume: 13 Issue: 1
- DOI
  10.1186/1476-4598-13-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293288
[Journal Article] mTOR plays critical roles in pancreatic cancer stem cells through specific and stemness-related functions.2013
- Author(s)
  Matsubara S, Ding Q, Miyazaki Y, Kuwahata T, Tsukasa K and Takao S
- Journal Title
  
  Scientific Report
  
  Volume: 3 Issue: 1
- DOI
  10.1038/srep03230
- NAID
  120005672468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293288
[Journal Article] Efficient Transfection of Primarily Cultured Porcine Embryonic Fibroblasts Using the Amaxa Nucleofection System2007
- Author(s)
  Nakayama A, Sato M, Shinohara M, Matsubara S, Yokomine T, Akasaka E, Yoshida M, Takao S
- Journal Title
  
  Cloning Stem Cells 9(4)
  
  Pages: 523-535
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500288
[Journal Article] Efficient Transfection of Primarily Cultured Porcine Embryonic Fibroblasts Using the Amaxa Nucleofection System2007
- Author(s)
  Nakayama A, Sato M, Shinohara M, Matsubara S, Yokomine T, Akasaka E, Yoshida M, Takao S.
- Journal Title
  
  Cloning Stem Cells 9(4)
  
  Pages: 523-535
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17500288
[Journal Article] Efficient transfection of primarily cultured porcine embryonic fibroblastusing the Amaxa Nucleofection SystemTM2007
- Author(s)
  Nakayama, A., Matsubara, S.他
- Journal Title
  
  Cloning and stem cells 9
  
  Pages: 523-534
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591489
[Journal Article] Efficient transfection of primarily cultured porcine embryonic fibroblasts using the Amaxa nucleofection system TM2007
- Author(s)
  Nakayama A, Sato M, Matsubara S, Yoshida M, Takao S.
- Journal Title
  
  Cloning Stem Cells 9
  
  Pages: 523-534
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17100007
[Journal Article] Efficient transfection of primarily cultured porcine embryonic fibroblast using the Amaxa Nucleofection System^<TM>2007
- Author(s)
  Nakayama A, Sato M, Shinohara M, Matsubara S, Yokomine T, Akasaka E, Yoshida M, Takao S.
- Journal Title
  
  Cloning and stem cells 9
  
  Pages: 523-534
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591489
[Journal Article] ミニブタの医学応用 -とくにクラウン系ミニブタについて-2006
- Author(s)
  高尾尊身, 藤吉利信, 松原修一郎, 上村亮三, 瀬戸山健太郎, 鳥取潤一
- Journal Title
  
  日本疾患モデル学会記録 22
  
  Pages: 64-69
- NAID
  130000760646
- Data Source
  KAKENHI-PROJECT-17500288
[Journal Article] Medical Application of Miniature Swine -Clawn Miniature Swine- ( in Japanese)2006
- Author(s)
  Takao S, Fujiyoshi T, Matsubara S, Kamimura R, Setoyama K, Tottori J
- Journal Title
  
  Arch. Association Jpn. Disease Model Animals 22
  
  Pages: 64-69
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500288
[Journal Article] ミニブタの医学応用-とくにクラウン系ミニブタについて2006
- Author(s)
  高尾尊身, 藤吉利信, 松原修一郎, 上村亮三, 瀬戸山健太郎, 鳥取潤一
- Journal Title
  
  日本疾患モデル学会記録 22
  
  Pages: 64-69
- NAID
  130000760646
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17500288
[Journal Article] 医用ミニブタの活用と将来展望-遺伝子改変モデル動物としての可能性2005
- Author(s)
  松原修一郎, 藤吉利信, 高尾尊身
- Journal Title
  
  アニテックス 17(5)
  
  Pages: 169-170
- Data Source
  KAKENHI-PROJECT-17100007
[Journal Article] 医用ミニブプタの活用と将来展望-バイオハザードの克服2005
- Author(s)
  藤吉利信, 松原修一郎, 高尾尊身
- Journal Title
  
  アニテックス 17(5)
  
  Pages: 162-163
- Data Source
  KAKENHI-PROJECT-17100007
[Journal Article] 医用ミニブタの活用と将来展望-遺伝子改変モデル動物としての可能性2005
- Author(s)
  松原修一郎
- Journal Title
  
  アニテックス 17(5)
  
  Pages: 169-170
- Data Source
  KAKENHI-PROJECT-17500288
[Journal Article] Midkine promoter-driven suicide gene expression and -mediated adenovirus replication produced cytotoxic effects to immortalised and tumour cells.2004
- Author(s)
  Yu, L., Hamada, K., Namba, M., Kadomatsu, K., Muramatsu, T., Matsubara, S., Tagawa, M.
- Journal Title
  
  Eur.J.Cancer 40-11
  
  Pages: 1787-1794
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570162
[Journal Article] Midkine promoter can mediate transcriptional activation of a fused suicide gene in a broader range of human breast cancer compared with c-erbB-2 promoter.2004
- Author(s)
  Yu, L., Yamamoto, N., Kadomatsu, K., Muramatsu, T., Matsubara, S., Sakiyama, S., Tagawa M.
- Journal Title
  
  Oncology 66-2
  
  Pages: 143-149
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570162
[Journal Article] Expression of α-catenin in α-catenin-deficient cells results in a reduced proliferation in three-dimensional multicellular spheroids but not in two-dimensional monolayer culture.2004
- Author(s)
  Matsubara, S., Ozawa, M.
- Journal Title
  
  Oncogene 23巻・15号
  
  Pages: 2694-2702
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16570162
[Journal Article] Expression of alpha-catenin in alpha-catenin-deficient cells results in a reduced proliferation in three-dimensional multicellular spheroids but not in two-dimensional monolayer culture.2004
- Author(s)
  Matsubara, S., Ozawa, M.
- Journal Title
  
  Oncogene 23巻,15号
  
  Pages: 2694-2702
- Data Source
  KAKENHI-PROJECT-16570162
[Journal Article] Expression of α-catenin in α-catenin-deficient cells results in a reduced proliferation in three-dimensional multicellular spheroids but not in two-dimensional monolayer culture.2004
- Author(s)
  Matsubara, S., Ozawa, M.
- Journal Title
  
  Oncogene 23-15
  
  Pages: 2694-2702
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570162
[Journal Article] Insertion of an exogenous promoter in the E1A regulatory region of adenovirus does not disturb viral replication despite reduced E1A transcription.2004
- Author(s)
  Yu, L., Hamada, K., Namba, M., Kadomatsu, K., Muramatsu, T., Matsubara, S., Tagawa M.
- Journal Title
  
  Cancer Lett. 203-1
  
  Pages: 51-57
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570162
[Presentation] Prevention of Akt phosphorylation is a key to targeting pancreatic cancer stem-like cells by mTORC1 inhibition.2020
- Author(s)
  Matsubara, S., Shimono, R., Furukawa, T., Takao, S.
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K08627
[Presentation] Differential functions of mTORC1 and mTORC2 in the maintenance of stem-like properties of pancreatic cancer cells2019
- Author(s)
  Matsubara, S., Tsukasa, K., Kuwabata, T., Obara, T., Matsuyama,T., Takao, S.
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K08627
[Presentation] Differential functions of mTORC1 and mTORC2 in the maintenance of stem-like properties of pancreatic cancer cells2018
- Author(s)
  Matsubara, S., Tsukasa, K., Kuwabata, T., Obara, T., Matsuyama, T., Takao, S.
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K08627
[Presentation] CD133陽性膵癌幹細胞様細胞においてmiR-30 familyは遊走と浸潤を促進する.2017
- Author(s)
  政幸一郎、丁強、宮崎優美、松原修一郎、上野祥子、小原徹、松山隆美、高尾尊身
- Organizer
  第35回日本ヒト細胞学会学術集会
- Data Source
  KAKENHI-PROJECT-26462069
[Presentation] EMT inducing signals in CD133+ pancreatic cancer cells2017
- Author(s)
  Matsubara S, Tsukasa K, Maeda K, Ding Q, Miyazaki Y, Obara T, Matsuyama T, Takao S.
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-26462069
[Presentation] mTOR複合体1(mTORC1) および2(mTORC2)はCD133陽性膵癌細胞の幹細胞様性質に関与する.2017
- Author(s)
  松原修一郎、政幸一郎、宮崎優美、小原　徹、松山隆美、高尾尊身
- Organizer
  第35回日本ヒト細胞学会学術集会
- Data Source
  KAKENHI-PROJECT-26462069
[Presentation] mTOR複合体1(mTORC1) および2(mTORC2)はCD133陽性膵癌細胞の幹細胞様性質維持に異なる作用をもつ.2017
- Author(s)
  松原修一郎、政幸一郎、小原　徹、松山隆美、高尾尊身
- Organizer
  2017年度生命科学系学会合同年次大会 (ConBio2017)
- Data Source
  KAKENHI-PROJECT-26462069
[Presentation] Hedgehog/GLI and mTOR signals in pancreatic cancer stem cells2016
- Author(s)
  Matsubara, S., Miyazaki, Y., Tsukasa, K., Obara, T., Matsuyama, T., Takao, S.
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜 (神奈川県横浜市)
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26462069
[Presentation] CD133陽性膵癌幹細胞様細胞におけるmiR-30 famiｌyの機能 The role of miR30 family in pancreatic cancer stem-like cells2016
- Author(s)
  政幸一郎、丁強、宮崎優美、松原修一郎、上野祥子、小原徹、松山隆美、高尾尊身
- Organizer
  第5回膵勉強会
- Place of Presentation
  ホテルセントコスモ (鹿児島県・鹿児島市)
- Year and Date
  2016-02-20
- Data Source
  KAKENHI-PROJECT-26462069
[Presentation] The influence of miR-30 family to migration of a pancreatic cancer cell line, Capan-12015
- Author(s)
  Tsukasa K, Miyazaki Y, Ueno S, Obara T, Matsubara S, Yoshimitsu M, Matsuyama T,Takao S
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場 (愛知県・名古屋市)
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-26462069
[Presentation] Significant signaling in KRAS downstream cascade maintaining the stem-like property of pancreatic cancer cells.2015
- Author(s)
  Matsubara S, Miyazaki Y, Tsukasa K, Obara T, Ueno S, Matsuyama T,Takao S
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場 (愛知県・名古屋市)
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26462069
[Presentation] CD133+ pancreatic cancer cells promote peritumonal fibrosis2015
- Author(s)
  Miyazaki Y, Yoshimitsu M, Tsukasa K, Matsubara S, Obara T, Matsuyama T,Takao S
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場 (愛知県・名古屋市)
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-26462069
[Presentation] 膵癌幹細胞の維持自己複製におけるmTORおよびHedgehogシグナルの機能 mTOR and Hedgehog signaling in pancreatic cancer stem cells2015
- Author(s)
  松原修一郎、宮崎優美、政幸一郎、上野祥子、小原徹、松山隆美、高尾尊身
- Organizer
  BMB2015
- Place of Presentation
  神戸国際展示場 (兵庫県・神戸市)
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-26462069
[Presentation] The influence of miR-30 family to migration of a pancreatic cancer cell line, Capan-1.2015
- Author(s)
  Koichiro Tsukasa, Shoko Ueno, Yumi Miyazaki, Toru Obara, Shyichiro Matsubara, Sonshin Takao
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋市
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-25293288
[Presentation] 膵癌幹細胞とKRAS- mTOR経路2015
- Author(s)
  松原修一郎、政幸一郎、宮崎優美、小原徹、高尾尊身
- Organizer
  第4回膵勉強会
- Place of Presentation
  ブルーウェーブイン鹿児島 (鹿児島県鹿児島市)
- Year and Date
  2015-03-07
- Data Source
  KAKENHI-PROJECT-26462069
[Presentation] Slug contributes to gemcitabine resistance through epithelial-mesenchymal transition in CD133+ pancreatic cancer cells.2015
- Author(s)
  Koichiro Tsukasa, Qiang Ding, Makoto Yoshimitsu, Yumi Miyazaki, Shyuichiro Matsubara, Shoko Ueno, Toru Obara , Takami Matsuyama, Sonshin Takao
- Organizer
  第33回ヒト細胞学会学術集会
- Place of Presentation
  宮崎市
- Year and Date
  2015-08-23
- Data Source
  KAKENHI-PROJECT-25293288
[Presentation] Slug contributes to gemcitabine resistance through epithelial-mesenchymal transition in CD133(+) pancreatic cancer cells.2015
- Author(s)
  Tsukasa K, Ding Q, Yoshimitsu M, Miyazaki Y, Matsubara S, Ueno S, Obara T, Matsuyama T,Takao S
- Organizer
  第32回日本ヒト細胞学会学術集会
- Place of Presentation
  ホテルスカイタワー (宮崎県・宮崎市)
- Year and Date
  2015-08-22
- Data Source
  KAKENHI-PROJECT-26462069
[Presentation] 膵癌幹細胞とKRAS – mTOR経路2015
- Author(s)
  松原修一郎、政幸一郎、宮崎優美、小原徹、高尾尊身
- Organizer
  第4回鹿児島膵勉強会
- Place of Presentation
  ブルーウェーブイン鹿児島（鹿児島県鹿児島市）
- Year and Date
  2015-03-07
- Data Source
  KAKENHI-PROJECT-25293288
[Presentation] Not only mTORC1 but also mTORC2 are involved in the function to maintain stem-like property of pancreatic cancer cells.2014
- Author(s)
  Matsubara S, Miyazaki Y, Tsukasa K, Obara T, Ueno S, Takao S
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  国際会議場（神奈川県横浜市）
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-25293288
[Presentation] The role of miR-30a in the highly migratory pancreatic cancer cell line.2014
- Author(s)
  Koichiro Tsukasa, Qiang Ding, Ryoko Imakiire, Shoko Ueno, Yumi Miyazaki, Toru Obara, Shyichiro Matsubara, Sonshin Takao
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  国際会議場（神奈川県横浜市）
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-25293288
[Presentation] Not only mTORC1 but also mTORC2 are involved in the function to maintain stem-like property of pancreatic cancer cells.2014
- Author(s)
  Matsubara S, Miyazaki Y, Tsukasa K, Obara T, Ueno S, Takao S
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜 (神奈川県横浜市)
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-26462069
[Presentation] The role of miR-30a in the highly migratory pancreatic cancer cell line2014
- Author(s)
  Tsukasa K, Matsubara S, Miyazaki Y, Obara T, Ueno S, Takao S
- Organizer
  第73回日本癌学会学術総会 (横浜)
- Place of Presentation
  パシフィコ横浜 (神奈川県横浜市)
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-26462069
[Presentation] クラウン系ミニブタのPERVのヒト細胞への感染性2009
- Author(s)
  藤吉利信、松原修一郎、高尾尊身
- Organizer
  第12回日本異種移植研究会
- Place of Presentation
  鹿児島
- Year and Date
  2009-03-07
- Data Source
  KAKENHI-PROJECT-17100007
[Presentation] クラウン系ミニブタのPERVのヒト細胞への感染性2009
- Author(s)
  藤吉利信, 松原修一郎, 丁強, 小原徹, 鳥取潤一, 高尾尊身
- Organizer
  日本畜産学会第110回大会
- Place of Presentation
  鹿児島
- Year and Date
  2009-03-07
- Data Source
  KAKENHI-PROJECT-17100007
[Presentation] クラウン系ミニブタのPERV のヒト細胞への感染性の検討2009
- Author(s)
  藤吉利信、松原修一郎、丁強、小原徹、鳥取潤一、高尾尊身
- Organizer
  第12回日本異種移植研究会
- Place of Presentation
  鹿児島大学
- Year and Date
  2009-03-07
- Data Source
  KAKENHI-PROJECT-19591489
[Presentation] クラウン系ミニブタPERVのヒト細胞への感染性の検討2009
- Author(s)
  藤吉利信, 松原修一郎, 他
- Organizer
  第12回日本異種移植研究会
- Place of Presentation
  鹿児島大学連合農学研究科棟3階大会室
- Year and Date
  2009-03-07
- Data Source
  KAKENHI-PROJECT-19591489
[Presentation] 異種移植の安全性に関する研究-クラウン系ミニブタ内在性レトロウイルスのヒトへの感染性2009
- Author(s)
  藤吉利信、松原修一郎、高尾尊身
- Organizer
  第9回日本分子生物学会春季シンポ
- Place of Presentation
  月宮崎
- Data Source
  KAKENHI-PROJECT-17100007
[Presentation] クラウン系ミニブタのPERV感染性の評価2008
- Author(s)
  藤吉利信、赤坂恵理、松原修一郎、鳥取潤一、高尾尊身
- Organizer
  第11回日本異種移植研究会
- Place of Presentation
  国立循環器病センター
- Year and Date
  2008-02-23
- Data Source
  KAKENHI-PROJECT-17100007
[Presentation] クラウン系ミニブタのPERVの感染性の評価2008
- Author(s)
  藤吉利信、松原修一郎, 高尾尊身, 他
- Organizer
  第11回日本異種移植研究会
- Place of Presentation
  国立循環器病センター
- Year and Date
  2008-02-23
- Data Source
  KAKENHI-PROJECT-19591489
[Presentation] クラウン系ミニブタのPERVの感染性の評価2008
- Author(s)
  藤吉利信、松原修一郎, 他
- Organizer
  第11回日本異種移植研究会
- Place of Presentation
  国立循環器病センター図書館講堂
- Year and Date
  2008-02-23
- Data Source
  KAKENHI-PROJECT-19591489
[Presentation] The mTOR pathway as a mechanism to maintain pancreatic cancer stem cell properties and a target to eliminate stem-like cells
- Author(s)
  Shyuichiro Matsubara, Qiang Ding, Yumi Miyazaki, Taisaku Kuwahata, Koichiro Tsukasa and Sonshin Takao
- Organizer
  第７２回日本癌学会学術総会
- Place of Presentation
  横浜市　パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25293288
[Presentation] CD133 facilitates pancreatic cancer metastasis by promoting epithelial-mesenchymal transition (EMT)
- Author(s)
  Qiang Ding, Makoto Yoshimitsu, Yumi Miyazaki, Toru Obara, Koichirou Tsukasa, Shyuichiro Matsubara, Sonshin Takao
- Organizer
  第７２回日本癌学会学術総会
- Place of Presentation
  横浜市　パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25293288
[Presentation] The role of noncoding RNAs in highly CD133-expressing pancreatic cancer stem-like cells
- Author(s)
  Koichiro Tsukasa, Qiang Ding, Ryoko Imakiire, Shoko Ueno, Yumi Miyazaki, Toru Obara, Shyichiro Matsubara, Sonshin Takao
- Organizer
  第７２回日本癌学会学術総会
- Place of Presentation
  横浜市　パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25293288
[Presentation] Role of Slug in chemoresistance, invasion and metastasis of CD133-expressing pancreatic cancer
- Author(s)
  Koichirou Tsukasa, Qiang Ding, Makoto Yoshimitsu, Yumi Miyazaki, Toru Obara, Shyuichiro Matsubara, Sonshin Takao
- Organizer
  American Association for Cancer Research (AACR) Annual Meeting 2013
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-25293288
[Presentation] GLI-1 plays a pivotal role in Hedgehog pathway on self-renewal of pancreatic cancer stem cells
- Author(s)
  Yumi Miyazaki, Qiang Ding, Makoto Yoshimitsu, Toru Obara, Koichirou Tsukasa, Shyuichiro Matsubara, Sonshin Takao
- Organizer
  American Association for Cancer Research (AACR) Annual Meeting 2013
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-25293288
[Presentation] Immunohistochemical comparative analysis of the sphere cells of CD133-positive pancreatic cancer cells with iPS cells
- Author(s)
  Yumi Miyazaki, Wang Yuqing, Kaoru Mitsui, Qiang Ding, Koichiro Tsukasa, Shyuichiro Matsubara, Kenichiro Kosai and Sonshin Takao
- Organizer
  第７２回日本癌学会学術総会
- Place of Presentation
  横浜市　パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25293288

1. TAKAO Sonshin (80171411)

# of Collaborated Projects: 6 results

# of Collaborated Products: 48 results
2. MURAMATSU Takashi (00030891)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. FUJIYOSHI Toshinobu (50173480)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
4. MATSUYAMA Takami (30145479)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. OZAWA Masayuki (90136854)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
6. YOSHIDA Mitsutoshi (00174954)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. ATO Masahiro (30287099)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. MARUYAMA Ikuro (20082282)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. BABA Masanori (70181039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. NAGAI TAKU (90363647)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. DING QIANG (80457647)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
12. YOSHIMITSU MAKOTO (70404530)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
13. MURAMATSU Hisako (50182134)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 友村美根子 (30217559)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 大久保儀 (90322320)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 新地洋之 (60284874)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 下野隆一 (60404521)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. 小戝健一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MATSUBARA Shyuichiro 松原 修一郎

Matsubara Shyichiro 松原 修一郎

MATSUBARA Shuichiro 松原 修一郎

松原 修一郎 マツバラ シユウイチロウ

Research Projects

Research Products

Co-Researchers

Research on targeted therapy of pancreatic cancer stem cells using exosomesPrincipal Investigator

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CD133 dependent signals and microRNAs in cancer stem cellsPrincipal Investigator

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Analysis of the interaction between the folate receptor beta expression macrophages and cancer stem cells in pancreatic cancer invasion

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Basic studies to produce genetically modified swine cells as the donor for nuclear-transferPrincipal Investigator

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A fundamental study on xenotransplantation

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Study on Safety of Xenotransplantation: Characterization of Porcine Endogenous Retrovirus of Clawn Miniature Swine

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Signal transduction from α-catenin and the mechanism of growth suppression dependent on cell-cell adhesion.Principal Investigator

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Studies on a new growth factor under the control of retinoic acid, midkine (MK)

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レチノイン酸による分化脱がん時に初期応答する遺伝子群の解析

Principal Investigator

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Research Institution

テラトカルシノーマの分化方向決定に関連する遺伝子の転写制御と機能

Principal Investigator

Project Period (FY)

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Research Institution

[Journal Article] Prevention of Akt phosphorylation is a key to targeting cancer stem-like cells by mTOR inhibition2020

Author(s)

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DOI

Data Source

[Journal Article] Efficient elimination of pancreatic cancer stem cells by Hedgehog/GLI inhibitor GANT61 in combination with mTOR inhibition.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] miR-30 family promotes migratory and invasive abilities in CD133+ pancreatic cancer stem-like cells.2016

Author(s)

Journal Title

Data Source

[Journal Article] miR-30 family promotes migratory and invasive abilities in CD133+ pancreatic cancer stem-like cells.2016

MATSUBARA Shyuichiro 松原修一郎

Matsubara Shyichiro 松原修一郎

MATSUBARA Shuichiro 松原修一郎

松原修一郎マツバラシユウイチロウ