Uchida Chiharu 内田千晴

… Alternative Names

UCHIDA Chiharu 内田千晴

内田千晴ウチダチハル

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Researcher Number	60223567
Other IDs
Affiliation (Current)	2025: 浜松医科大学, 光医学総合研究所, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2025: 浜松医科大学, 光医学総合研究所, 准教授 2017 – 2023: 浜松医科大学, 光尖端医学教育研究センター, 准教授 2016: 浜松医科大学, 先進機器共用推進部, 准教授 2015: 浜松医科大学, 光尖端医学教育研究センター, 准教授 2007 – 2008: Hamamatsu University School of Medicine, 医学部, 助教 … More 2006: Hamamatsu Univ. Sch. Med., Assistant Prof, 医学部, 助教授 1997 – 2006: 浜松医科大学, 医学部, 助手 2004: 国立大学法人浜松医科大学, 医学部, 助手 1995: 浜松医科大学, 医学部, 助手 1993: 浜松医科大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator General medical chemistry / General medical chemistry / Basic Section 63020:Radiation influence-related / Basic Section 50010:Tumor biology-related / Molecular biology / Biological Sciences Except Principal Investigator Biological Sciences / Functional biochemistry / General medical chemistry / Basic Section 50010:Tumor biology-related … More / Basic Section 37030:Chemical biology-related / Basic Section 38050:Food sciences-related / Tumor biology / Functional biochemistry / Cell biology Less
Keywords	Principal Investigator ユビキチン / 細胞周期 / プロテアソーム / DNA複製ストレス / RBファミリー / 複製ストレス / がん抑制遺伝子 / ETAA1 / ATR / 染色体不安定性 … More / p130RB2 / がん抑制因子 / DNA損傷・修復 / RB ファミリー / Cell cycle / Degradation / Proteasome / Ubiquitin / p27kip1 / p27<kip1> / 分解 / p27^<Kip1> / がん化 / DNA複製 / クロマチン / pRB / E1A / p27 / 癌 / RBタンパク質 / 癌抑制遺伝子産物 / TATA-lessプロモーター / セリンピルビン酸アミノ転移酵素 / 肝特異的 / 転写制御 / Sp1 / AP-2 / PKA / cAMP / 転写開始機構 / 遺伝子発現 / セリン:ピルビン酸アミノ転移酵素 / 転写因子 / TATA-lessプロモータ / セリン:ピルビン酸アミノ基転移酵素 … More Except Principal Investigator 細胞周期 / p27^<Kip1> / 癌 / RBタンパク質 / ユビキチン / プロテアソーム / 予後 / セリンアミノ転移酵素 / Cell cycle / ユビキチンリガーゼ / リン酸化 / ペルオキシソーム / ノンコーディングRNA / RB / cancer / RB protein / prognosis / Ubiquitin ligase / ユビキチン化 / タンパク質の質と量の制御 / タンパク質過剰産生ストレス / 細胞応答 / 誘導性小胞体膜 / オルガネラ移行配列 / クリスタロイド小胞体 / タンパク質過剰発現 / 発がん / p53 / p27Kip1 / 癌抑制遺伝子産物 / ジーンターゲッティング / 遺伝子治療 / ユビキチン-プロテアソーム / ノックアウトマウス / 膜透過 / ミトコンドリア / オルガネラ局在化機構 / がん / 細胞運命 / シグナル伝達 / 細胞運命制御 / エピゲノム制御 / 長鎖ノンコーディングRNA / ビリ蛋白質 / ビリン類 / 蛍光蛋白質 / 賦活化 / 抗腫瘍免疫能 / 腫瘍 / ケトン / メトフォルミン / ケトン食 / quality of life / tumor / CT26 / ketogenic diet / metformin / lncRNA / cell response / inducible ER / organelle targeting signal / crystalloid endoplasmic reticulum / protein overexpression / タンパク質過剰発見 / ubiquitin / Mdm2 / 癌化 / Gene therapy / p27^<kip1> / serine aminotransferase / peroxisomes / mitochondria / organelle translocations / targeting signal / ペルオキシソーム移行シグナル / ミトコンドリア移行シグナル / 高次構造 / 局在化シグナル / ペルオキシソール / オルガネラ局在 / 標的シグナル / p27 / サイクリン / Skp2 / タンパク質分解 / 大腸癌 / CDK / ウレタン / 肺胞細胞 / 細気管支 / 肺発癌 / 肺分化 / 肺発生 / LUN遺伝子 / 鰓弓 / 大動脈弓 / エンドセリン受容体A / 神経堤 / MFH-1 / 22q11.2症候群 / 尿酸酸化酵素 / 変性 / シャペロン活性 / ペルオキシゾーム / 細胞内移行シグナル / 蛋白質の細胞内局在化 / オルガネラ移行 / 転写調節 Less

がん抑制因子の機能不全によるDNA修復亢進とがん細胞の耐性獲得の機序Principal Investigator
- Principal Investigator
  
  内田千晴
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Hamamatsu University School of Medicine
Cell fate control by lncRNA regulating genetic specificities of epigenetic factors
- Principal Investigator
  
  北川雅敏
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Hamamatsu University School of Medicine
新規イメージングプローブ開発を目指した魚類の赤色蛍光蛋白質の機能解析
- Principal Investigator
  
  合田真
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Hamamatsu University School of Medicine
The tumor suppressor p130RB2 functions in replication stress response and suppression of chromosome instabilityPrincipal Investigator
- Principal Investigator
  
  UCHIDA Chiharu
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Hamamatsu University School of Medicine
The mechanism by which a ketogenic diet activates anti-tumor immune function and suppresses tumor growth.
- Principal Investigator
  
  NAKATA Takahiro
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Tokoha University
RB family functions in regulation of replication stress checkpointPrincipal Investigator
- Principal Investigator
  
  UCHIDA CHIHARU
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Hamamatsu University School of Medicine
Long non-coding RNA associated with cancer stemness
- Principal Investigator
  
  KITAGAWA Masatoshi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor biology
- Research Institution
  Hamamatsu University School of Medicine
Regulation of DNA replication and repair by ubiquitin or ubiquitin-like modification in cancer cellsPrincipal Investigator
- Principal Investigator
  
  UCHIDA Chiharu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Hamamatsu University School of Medicine
p53制御分子Pirh2の新たなユビキチン化標的分子とがん化との関連
- Principal Investigator
  
  北川雅敏
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hamamatsu University School of Medicine
タンパク質の誤局在、過剰産生ストレスに対する膜構造変化を伴う細胞応答
- Principal Investigator
  
  小田敏明
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hamamatsu University School of Medicine
個体レベルでの細胞周期のリアルタイムイメージングの試み
- Principal Investigator
  
  北川雅敏
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Hamamatsu University School of Medicine
Degradation of the CDK inhibitor p27^<Kip1> by a novel ubiquitin ligase.Principal Investigator
- Principal Investigator
  
  UCHIDA Chiharu
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Hamamatsu University School of Medicine
Ubiquitination of overexpressed protein and enclosure by inducible ER membrane
- Principal Investigator
  
  ODA Toshiaki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Hamamatsu University School of Medicine
p27^<Kip1>の発現量低下を伴う予後不良の癌の分子標的の同定
- Principal Investigator
  
  北川雅敏
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hamamatsu University School of Medicine
RBファミリータンパク質のリン酸化と分解を介した細胞周期制御機構
- Principal Investigator
  
  北川雅敏
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hamamatsu University School of Medicine
Regulation of tumor suppressor RB pathway via ubiquitin system.
- Principal Investigator
  
  KITAGAWA Masatoshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hamamatsu University School of Medicine
蛋白質安定化機能を持つ新規p27^<kip1>結合因子の癌化抑制への関与Principal Investigator
- Principal Investigator
  
  内田千晴
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hamamatsu University School of Medicine
p27^<kip1>の発現量低下による予後不良の癌形質の形成メカニズムの研究
- Principal Investigator
  
  北川雅敏
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hamamatsu University School of Medicine
RBタンパク質のリン酸化と分解を介した標的遺伝子選択的制御機構
- Principal Investigator
  
  北川雅敏
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hamamatsu University School of Medicine
RBタンパク質の部位特異的リン酸化および分解による標的遺伝子の選択的発現制御機構Principal Investigator
- Principal Investigator
  
  内田千晴
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Hamamatsu University School of Medicine
Accelerated degradation of tumor suppressor gene products in human cancers
- Principal Investigator
  
  KITAGAWA Masatoshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE
RBタンパク質の部位特異的リン酸化を介した標的遺伝子選択的制御機構
- Principal Investigator
  
  北川雅敏
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Hamamatsu University School of Medicine
p27^<kip1>のコンデショナルノックアウトによるヒト腫瘍の悪性化の解析
- Principal Investigator
  
  北川雅敏
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Hamamatsu University School of Medicine
ゲノム資源とノックアウトマウスを用いた22q11.2症候群の成因の解明
- Principal Investigator
  
  三浦直行
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Hamamatsu University School of Medicine
肺発生、肺分化、肺発癌におけるフォークヘッド遺伝子LUNの役割
- Principal Investigator
  
  三浦直行
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Hamamatsu University School of Medicine
分解耐性型p27kip1の分子デザインと癌治療への応用
- Principal Investigator
  
  KITAGAWA Masatoshi
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Hamamatsu University School of Medicine
Application of ubiquitin ligase against tumor suppressor gene products for cancer therapy
- Principal Investigator
  
  KITAGAWA Masatoshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hamamatsu University School of Medicine
二重のプロモーターに支配されるセリンアミノ転移酵素遺伝子の転写開始機構Principal Investigator
- Principal Investigator
  
  内田千晴
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Hamamatsu University School of Medicine
ペルオキシソーム酵素の膜透過時の構造解析
- Principal Investigator
  
  小田敏明
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Hamamatsu University School of Medicine
Analysis of mechanism for selective translocation of a protein having two subcellular localization signals
- Principal Investigator
  
  ODA Toshiaki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hamamatsu University School of Medicine
ペルオキシゾームに検出されるセリンアミノ転移酵素変性活性の解析
- Principal Investigator
  
  小田敏明
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hamamatsu University School of Medicine
ラット肝セリンアミノ転移酵素の2種のオルガネラ移行シグナルの相互作用の解析
- Principal Investigator
  
  小田敏明
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Hamamatsu University School of Medicine
ラットセリンアミノ転移酵素遺伝子の下流側TATA-lessプロモータの解析Principal Investigator
- Principal Investigator
  
  内田千晴
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Hamamatsu University School of Medicine
ラット肝セリンアミノ転移酵素の細胞内二重局在を規定する分子機構
- Principal Investigator
  
  ODA Toshiaki
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hamamatsu University School of Medicine

All 2023 2019 2016 2008 2007 2006 2005 Other

All Journal Article Presentation

[Journal Article] p130RB2 positively contributes to ATR activation in response to replication stress via the RPA32-ETAA1 axis2023
- Author(s)
  Uchida Chiharu、Niida Hiroyuki、Sakai Satoshi、Iijima Kenta、Kitagawa Kyoko、Ohhata Tatsuya、Shiotani Bunsyo、Kitagawa Masatoshi
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  
  Volume: 1870 Issue: 6 Pages: 119484-119484
- DOI
  10.1016/j.bbamcr.2023.119484
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06662, KAKENHI-PROJECT-20K07614, KAKENHI-PROJECT-23K24999
[Journal Article] Long Noncoding RNA ELIT-1 Acts as a Smad3 Cofactor to Facilitate TGFβ/Smad Signaling and Promote Epithelial-Mesenchymal Transition.2019
- Author(s)
  Sakai S, Ohhata T, Kitagawa K, Uchida C, Aoshima T, Niida H, Suzuki T, Inoue Y, Miyazawa K, Kitagawa M.
- Journal Title
  
  Cancer Res
  
  Volume: 79(11) Issue: 11 Pages: 2821-38
- DOI
  10.1158/0008-5472.can-18-3210
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08727, KAKENHI-PROJECT-18K06660, KAKENHI-PROJECT-16H04696, KAKENHI-PROJECT-16K08580, KAKENHI-PROJECT-16K07250, KAKENHI-PROJECT-19H03501
[Journal Article] Long Non-coding RNA, PANDA, Contributes to the Stabilization of p53 Tumor Suppressor Protein.2016
- Author(s)
  Kotake Y, Kitagawa K, Ohhata T, Sakai S, Uchida C, Niida H, Naemura M, Kitagawa M.
- Journal Title
  
  Anticancer Res.
  
  Volume: 36 Pages: 1605-1611
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26640073
[Journal Article] Roles of pRB in the Regulation of Nucleosome and Chromatin Structures.2016
- Author(s)
  Uchida C
- Journal Title
  
  Biomed Research International
  
  Volume: - Pages: 1-11
- DOI
  10.1155/2016/5959721
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07250
[Journal Article] RING-, HECT-, and RBR-type E3 Ubiquitin Ligases: Involvement in Human Cancer.2016
- Author(s)
  Uchida C, Kitagawa M
- Journal Title
  
  Curr. Cancer Drug Targets
  
  Volume: 16(2) Pages: 157-174
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07250
[Journal Article] Pirh2 interacts with and ubiquitylates signal recognition particle receptor beta subunit2008
- Author(s)
  Abe, K., Hattori, T., Isobe, T., Kitagawa, K., Oda, T., Uchida, C., Kitagawa, M.
- Journal Title
  
  Biomed Res 29
  
  Pages: 53-60
- NAID
  130004470702
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590272
[Journal Article] ARA54 is involved in transcriptional regulation of the cyclin D1 gene in human cancer cells2007
- Author(s)
  Kikuchi, H, Uchida, C, Hattori, T, Isobe, T, Hiramatsu, Y, Kitagawa, K, Oda, T, Konno, H, Kitagawa, M.
- Journal Title
  
  Carcinogenesis 28
  
  Pages: 1752-1758
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590272
[Journal Article] Pirh2 Promotes Ubiquitin-Dependent Degradation of the CDK Inhibitor p27Kip12007
- Author(s)
  Hattori, T, Isobe, T, Abe, K, Kikuchi, H, Kitagawa, K, Oda, T, Uchida, C, Kitagawa, M.
- Journal Title
  
  Cancer Research 67
  
  Pages: 10789-10795
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590272
[Journal Article] Renal damage in obstructive nephropathy is decreased in Skp2-deficient mice.2007
- Author(s)
  Suzuki, S., Fukasawa, H., Kitagawa, K., Uchida, C., Hattori, T., Isobe, T., Oda, T., Misaki, T., Ohashi, N., Nakayama, K., Nakayama, K.I., Hishida, A., Yamamoto, T., Kitagawa, M.
- Journal Title
  
  Am. J. Pathol. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590244
[Journal Article] Contribution of Extracellular Signal-Regulated Kinases to the IL-1-induced Growth Inhibition of Human Melanoma Cells A3752007
- Author(s)
  Arakawa, T, Yamamura, T, Hattori, T, Hayashi H, Mori, A, Yoshida, A, Uchida, C, Kitagawa, M, Onozaki, K.
- Journal Title
  
  International Immunopharmacology 8
  
  Pages: 80-89
- Data Source
  KAKENHI-PROJECT-19590272
[Journal Article] Renal damage in obstructive nephropathy is decreased in Skp2-deficient mice. Am2007
- Author(s)
  Suzuki, S, Fukasawa, H, Kitagawa, K, Uchida, C, Hattori, T, Isobe, T, Oda, T, Misaki, T, Ohashi, N, Nakayama, K, Nakayama, K, I., Hishida, A, Yamamoto, T, Kitagawa, M.
- Journal Title
  
  J.Pathol 171
  
  Pages: 473-483
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590272
[Journal Article] Renal damage in obstructive nephropathy is decreased in Skp2-deficient mice.2007
- Author(s)
  Suzuki, S., Fukasawa, H., Kitagawa, K., Uchida, C., Hattori, T., Isobe, T., Oda, T., Misaki, T., Ohashi, N., Nakayama, K., Nakayama, K.I., Hishida, A., Yamamoto, T., Kitagawa M.
- Journal Title
  
  Am. J. Pathol. (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590244
[Journal Article] Mdm2-mediated pRB downregulation is involved in carcinogenesis in a p53-independent manner.2006
- Author(s)
  Miwa, S., Uchida, C., Kitagawa, K., Hattori, T., Oda, T., Sugimura, H., Yasuda, H., Nakamura, H., Chida K., Kitagawa, M.
- Journal Title
  
  Biochem Biophys Res Commun. 340
  
  Pages: 54-61
- Data Source
  KAKENHI-PROJECT-17590244
[Journal Article] Mdm2-mediated pRB downregulation is involved in carcinogenesis in a p53-independent manner.2006
- Author(s)
  Miwa, S., Uchida, C., Kitagawa, K., Hattori, T., Oda, T., Sugimura, H., Yasuda, H., Nakamura, H.Chida K., Kitagawa, M.
- Journal Title
  
  Biochem Biophys Res Commun. 340
  
  Pages: 54-61
- Data Source
  KAKENHI-PROJECT-17028021
[Journal Article] Effect of MdmX on Mdm2-mediated downregulation of pRB.2006
- Author(s)
  Uchida, C.
- Journal Title
  
  FEBS Letters 560
  
  Pages: 1753-1758
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370060
[Journal Article] Up-regulation of GPR48 induced by down-regulation of p27^<Kip1> enhances carcinoma cell invasiveness and metastasis2006
- Author(s)
  Gao, Y., Kitagawa, K., Hiramatsu, Y., Kikuchi, H., Isobe, T., Shimada, M., Uchida, C., Hattori, T., Oda, T., Nakayama, K., Nakayama, K.I., Tanaka, T., Konno, H., Kitagawa, M.
- Journal Title
  
  Cancer Res 66
  
  Pages: 11623-11631
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590244
[Journal Article] Effect of MdmX on Mdm2-mediated downregulation of pRB2006
- Author(s)
  Uchida, C.
- Journal Title
  
  FEBS Letters 580
  
  Pages: 1753-1758
- Data Source
  KAKENHI-PROJECT-17028021
[Journal Article] Ubiquitin-dependent degradation of adenovirus E1A protein is inhibited by BS69.2006
- Author(s)
  Isobe, T., Uchida, C., Hattori, T., Kitagawa, K., Oda, T., Kitagawa, M.
- Journal Title
  
  Biochem Biophys Res Commun. 339
  
  Pages: 367-374
- Data Source
  KAKENHI-PROJECT-17028021
[Journal Article] Effects of MdmX on Mdm2-mediated downregulation of pRB.2006
- Author(s)
  Uchida, C., Miwa, S., Isobe, T., Kitagawa, K., Hattori, T., Oda, T., Yasuda, H., Kitagawa, M.
- Journal Title
  
  FEBS Letters 560
  
  Pages: 1753-1758
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590244
[Journal Article] Ubiquitin-dependent degradation of SnoN and Ski is increased in renal fibrosis induced by obstructive injury2006
- Author(s)
  Fukasawa, H., Yamamoto, T., Togawa, A., Ohashi, N., Fujigaki, Y., Oda T., Uchida C., Kitagawa, K., Hattori, T., Suzuki, S., Kitagawa, M., Hishida
- Journal Title
  
  Kidney Int 69
  
  Pages: 1733-1740
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590244
[Journal Article] Mdm2-mediated pRB downregulation is involved in carcinogenesis in a p53-independent manner2006
- Author(s)
  Miwa, S., Uchida, C., Kitagawa, K., Hattori, T., 0da, T., Sugimura, H., Yasuda, H., Nakamura, H., Chida K., Kitagawa, M
- Journal Title
  
  Biochem Biophys Res Commun 340
  
  Pages: 54-61
- Data Source
  KAKENHI-PROJECT-17590244
[Journal Article] Effect of MdmX on Mdm2-mediated downregulation of pRB.2006
- Author(s)
  Uchida, C et al.
- Journal Title
  
  FEBS Letters 560
  
  Pages: 1753-1758
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370060
[Journal Article] Degradation of Tob1 Mediated by SCF^<ska2>-Dependent Ubiquitination2006
- Author(s)
  Hiramatsu, Y., Kitagawa, K., Suzuki, T., Uchida, C., Hattori, T., Kikuchi, H., Oda, T., Hatakeyama, S., Nakayama, KI., Yamamoto, T., Konno, H., Kitagawa M.
- Journal Title
  
  Cancer Res 66
  
  Pages: 8477-8483
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590244
[Journal Article] Degradation of Tobl Mediated by SkP2-Dependent Ubiquitination2006
- Author(s)
  Hiramatsu, Y., Kitagawa, K., Suzuki, T., Uchida, C., Hattori, T., Kikuchi, H., Oda T., Hatakeyama, S., Nakayama, KI., Yamamoto, T., Konno, H., Kitagawa M.
- Journal Title
  
  Cancer Res. 66
  
  Pages: 8477-8483
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590244
[Journal Article] Mdm2-mediated pRB downregulation is involved in carcinogenesis in a p53-independent manner2006
- Author(s)
  Miwa, S., Uchida, C., Kitagawa, K., Hattori, T., Oda, T., Sugimura, H., Yasuda, H., Nakamura, H., Chida K., Kitagawa, M.
- Journal Title
  
  Biochem Biophys Res Commun 340
  
  Pages: 54-61
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590244
[Journal Article] Generation of a constitutively active mutant of human GPR48/LGR4, a G-protein-coupled receptor2006
- Author(s)
  Gao, Y., Kitagawa, K., Shimada, M., Uchida, C., Hattori, T., Oda, T., Kitagawa, M.
- Journal Title
  
  H. J. Med. Sci(北海道医誌). 81
  
  Pages: 101-109
- NAID
  10029919292
- Data Source
  KAKENHI-PROJECT-17590244
[Journal Article] Ubiquitin-dependent degradation of adenovirus E1A protein is inhibited by BS69.2006
- Author(s)
  Isobe, T., Uchida, C., Hattori T., Kitagawa, K., Oda, T., Kitagawa, M.
- Journal Title
  
  Biochem Biophys Res Commun 339
  
  Pages: 367-374
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590244
[Journal Article] Up-regulation of GPR48 induced by down-regulation of p27^<Kip1> enhances carcinoma cell invasiveness and metastasis2006
- Author(s)
  Gao, Y., Kitagawa, K., Hiramatsu, Y., Kikuchi, H., Isobe, T., Shimada, M., Uchida.C., Hattori, T., Oda.T., Nakayama, K., Nakayama, K.I., Tanaka, T., Konno, H., Kitagawa.M
- Journal Title
  
  Cancer Res 66
  
  Pages: 11623-11631
- Data Source
  KAKENHI-PROJECT-17590244
[Journal Article] Ubiqui tin-dependent degradation of SnoN and Ski is increased in renal fibrosis induced by obstructive injury2006
- Author(s)
  Fukasawa, H., Yamamoto, T., Togawa, A., Ohashi, N., Fujigaki, Y., Oda, T., Uchida, C., Kitagawa, K., Hattori, T., Suzuki, S., Kitagawa, M., Hishida
- Journal Title
  
  Kidney Int. 69
  
  Pages: 1733-1740
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590244
[Journal Article] Effects of MdmX on Mdm2-mediated downregulation of pRB.2006
- Author(s)
  Uchida, C., Miwa, S., Isobe, T., Kitagawa, K., Hattori, T., Oda.T., Yasuda, H., Kitagawa.M.
- Journal Title
  
  FEBS Letters 560
  
  Pages: 1753-1758
- Data Source
  KAKENHI-PROJECT-17590244
[Journal Article] Ubiquitin-dependent degradation of adenovirus E1A protein is inhibited by BS69.2006
- Author(s)
  Isobe, T., Uchida.C., Hattori, T., Kitagawa, K., Oda, T., Kitagawa, M
- Journal Title
  
  Biochem Biophys Res Commun 339
  
  Pages: 367-374
- Data Source
  KAKENHI-PROJECT-17590244
[Journal Article] Ubiquitin-dependent degradation of adenovirus E1A protein is inhibited by BS69.2006
- Author(s)
  Isobe, T., Uchida, C., Hattori, T., Kitagawa, K., Oda, T., Kitagawa, M.
- Journal Title
  
  Biochem Biophys Res Commun. 339
  
  Pages: 367-374
- Data Source
  KAKENHI-PROJECT-17590244
[Journal Article] Ubiquitin-dependent degradation of SnoN and Ski is increased in renal fibrosis induced by obstructive injury2006
- Author(s)
  Fukasawa, H., Yamamoto, T., Togawa, A., Ohashi, N., Fujigaki, Y., Oda, T., Uchida C., Kitagawa, K., Hattori, T., Suzuki, S., Kitagawa, M., Hishida
- Journal Title
  
  Kidney Int 69
  
  Pages: 1733-1740
- Data Source
  KAKENHI-PROJECT-17590244
[Journal Article] Effects of MdmX on Mdm2-mediated downregulation of pRB.2006
- Author(s)
  Uchida, C., et al.
- Journal Title
  
  FEBS letters. 580
  
  Pages: 1753-1758
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590243
[Journal Article] Ubiquitin-dependent degradation of adenovirus E1A protein is inhibited by BS69.2006
- Author(s)
  Isobe, T., Uchida, C., Hattori, T., Kitagawa, K., Oda, T., Kitagawa, M
- Journal Title
  
  Biochem Biophys Res Commun. 339
  
  Pages: 367-374
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590244
[Journal Article] Generation of a constitutively active mutant of human GPR48/LGR4, a G-protein-coupled receptor2006
- Author(s)
  Gao, Y., Kitagawa, K., Shimada, M., Uchida, C., Hattori, T., Oda, T., Kitagawa.M.
- Journal Title
  
  H. J. Med. Sci.(北海道医誌). 81
  
  Pages: 101-109
- NAID
  10029919292
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590244
[Journal Article] Up-regulation of GPR48 induced by down-regulation of p27kip1 enhances carcinoma cell invasiveness and metastasis2006
- Author(s)
  Gao, Y., Kitagawa, K., Hiramatsu, Y., Kikuchi, H., Isobe, T., Shimada, M., Uchida, C., Hattori, T., Oda, T., Nakayama, K., Nakayama, K.I., Tanaka, T., Konno, H., Kitagawa, M
- Journal Title
  
  Cancer Res. 66
  
  Pages: 11623-11631
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590244
[Journal Article] Degradation of Tobl Mediated by SCF^<Skp2>-Dependent Ubiquitination2006
- Author(s)
  Hiramatsu, Y., Kitagawa, K., Suzuki, T., Uchida, C., Hattori, T., Kikuchi, H., Oda, T., Hatakeyama, S., Nakayama, KI., Yamamoto, T., Konno, H., Kitagawa M.
- Journal Title
  
  Cancer Res 66
  
  Pages: 8477-8483
- Data Source
  KAKENHI-PROJECT-17590244
[Journal Article] Effects of MdmX on Mdm2-mediated downregulation of pRB2006
- Author(s)
  Uchida, C., et al.
- Journal Title
  
  FEBS letters. 580
  
  Pages: 1753-1758
- Data Source
  KAKENHI-PROJECT-17590243
[Journal Article] Effect of MdmX on Mdm2-mediated downregulation of pRB.2006
- Author(s)
  Uchida, C. et al.
- Journal Title
  
  FEBS Letters 580
  
  Pages: 1753-1758
- Data Source
  KAKENHI-PROJECT-17659079
[Journal Article] Effects of MdmX on Mdm2-ediated downregulation of pRB2006
- Author(s)
  Uchida, C., Miwa, S., Isobe, T., Kitagawa, K., Hattori, T., Oda, T., Yasuda, H., Kitagawa, M.
- Journal Title
  
  FEBS Letters 560
  
  Pages: 1753-1758
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590244
[Journal Article] Mdm2-mediated pRB downregulation is involved in carcinogenesis in a p53-independent manner2006
- Author(s)
  Miwa, S., Uchida C., Kitagawa, K., Hattori, T., Oda, T., Sugimura, H., Yasuda, H., Nakamura, H.Chida K., Kitagawa, M
- Journal Title
  
  Biochem Biophys Res Commun 340
  
  Pages: 54-61
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590244
[Journal Article] Generation of a constitutively active mutant of human GPR48/LGR4, a G-protein-coupled receptor2006
- Author(s)
  Gao, Y., Kitagawa, K., Shimada, M., Uchida, C., Hattori, T., Oda, T., Kitagawa, M.
- Journal Title
  
  H.J.Med.Sci(北海道医誌). 81
  
  Pages: 101-109
- NAID
  10029919292
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590244
[Journal Article] Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation.2005
- Author(s)
  Chiharu Uchida et al.
- Journal Title
  
  EMBO J. 24
  
  Pages: 160-169
- Data Source
  KAKENHI-PROJECT-16026214
[Journal Article] Transcriptional induction of Smurf2 ubiquitin ligase by TGF-b.2005
- Author(s)
  Ohashi, N., Yamamoto, T., Uchida, C., Togawa, A., Fukasawa, H., Fujigaki, Y., Suzuki, S., Kitagawa, K., Hattori, T., Oda, T., Hayashi, H., Hishida, A., Kitagawa, M
- Journal Title
  
  FEBS Letters 579
  
  Pages: 2557-2563
- Data Source
  KAKENHI-PROJECT-17028021
[Journal Article] Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation.2005
- Author(s)
  Uchida, C., et al.
- Journal Title
  
  EMBO J. 24
  
  Pages: 160-169
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590243
[Journal Article] Enhanced Mdm2 activity inhibits pRB function via ubiquitindependent degradation.2005
- Author(s)
  Uchida, C et al.
- Journal Title
  
  EMBO J. 24
  
  Pages: 160-169
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370060
[Journal Article] Transcriptional induction of Smurf2 ubiquitin ligase by TGF-b.2005
- Author(s)
  Ohashi, N., Yamamoto, T., Uchida, C., Togawa, A., Fukasawa, H., Fujigaki, Y., Suzuki, S., Kitagawa, K., Hattori, T., Oda, T., Hayashi, H., Hishida, A., Kitagawa, M
- Journal Title
  
  FEBS Letters 579
  
  Pages: 2557-2563
- Data Source
  KAKENHI-PROJECT-17590244
[Journal Article] Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation.2005
- Author(s)
  Chiharu Uchida et al.
- Journal Title
  
  EMBO J. 24
  
  Pages: 160-169
- Data Source
  KAKENHI-PROJECT-16021220
[Journal Article] Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation.2005
- Author(s)
  Uchida C., Miwa S., Kitagawa K., Hattori T., Isobe T., Otani S., Oda T., Sugimura H., Kamijo T., Ookawa K., Yasuda H., Kitagawa M.
- Journal Title
  
  EMBO J. 24
  
  Pages: 160-169
- Data Source
  KAKENHI-PROJECT-17028021
[Journal Article] Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation.2005
- Author(s)
  Chiharu Uchida et al.
- Journal Title
  
  EMBO J. 24
  
  Pages: 160-169
- Data Source
  KAKENHI-PROJECT-16370060
[Journal Article] Enhanced Mdm2 activity ibhibits pRB function via ubiquitin-dependent degradation.2005
- Author(s)
  Uchida C., Miwa S., Kitagawa K., Hattori T., Isobe T., Otani S., Oda T., Sugimura H., Kamijo T., Ookawa K., Yasuda H., Kitagawa M.
- Journal Title
  
  EMBO J. 24
  
  Pages: 160-169
- Data Source
  KAKENHI-PROJECT-17590244
[Journal Article] Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation.2005
- Author(s)
  Uchida, C.
- Journal Title
  
  EMBO J. 24
  
  Pages: 160-169
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370060
[Journal Article] Ubiquitin-dependent degradation of SnoN and Ski is increased in renal fibrosis induced by obstructive injury.
- Author(s)
  Fukasawa, H., Yamamoto, T., Togawa, A., Ohashi, N., Fujigaki, Y., Oda, T., Uchida, C., Kitagawa, K., Hattori, T., Suzuki, S., Kitagawa, M., Hishida, A
- Journal Title
  
  Kidney Int. (in press)
- Data Source
  KAKENHI-PROJECT-17590244
[Journal Article] Ubiquitin-dependent degradation of SnoN and Ski is increase in renal fibrosis induced by obstructive injury.
- Author(s)
  Fukasawa, H., Yamamoto, T., Togawa, A., Ohashi, N., Fujigaki, Y., Oda, T., Uchida, C., Kitagawa, K., Hattori, T., Suzuki, S., Kitagawa, M., Hishida, A
- Journal Title
  
  Kidney Int. (in press)
- Data Source
  KAKENHI-PROJECT-17028021
[Presentation] p130RB2 positively contributes to ATR activation in response to replication stress2023
- Author(s)
  Uchida C, Niida H, Sakai S, Ohhata T, Shiotani B, Kitagawa M.
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07614
[Presentation] Positive role of p130RB2 in ATR activation in response to replication stress2023
- Author(s)
  Uchida C, Niida H, Shiotani B, Kitagawa M.
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K07614
[Presentation] p130RB2は複製ストレス応答におけるATR活性化へ正に関与する2023
- Author(s)
  内田千晴
- Organizer
  日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07614
[Presentation] p130RB2は DNA複製ストレスにおける ATR活性化に正に関わる2019
- Author(s)
  内田千晴、丹伊田　浩行、北川雅敏
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K07250
[Presentation] GPR48による癌転移機構の解析2008
- Author(s)
  磯部智康, 島田真衣, 劉寧, 北川恭子, 鈴木小由里, 小田敏明, 服部隆行, 内田千晴, 北川雅敏
- Organizer
  第31回日本分子生物学会、第81回日本生化学会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-19590272
[Presentation] タンパク質過剰発現誘導性小胞体の構造と機能2008
- Author(s)
  小田敏明, 服部隆行, 磯部智康, 北川恭子, 内田千晴, 横田貞記, 北川雅敏
- Organizer
  第31回日本分子生物学会、第81回日本生化学会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-19590272
[Presentation] 腎障害進行におけるSkp2発現亢進の解析 : Skp2KOマウスを用いた検討2007
- Author(s)
  鈴木小由里, 深澤洋敬, 北川恭子, 戸川証大橋温, 小田敏明, 内田千晴, 服部隆行, 中山敬一, 山本龍夫, 菱田明, 北川雅敏
- Organizer
  第30回日本分子生物学会、第80回日本生化学会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-07
- Data Source
  KAKENHI-PROJECT-19590272

1. KITAGAWA Masatoshi (50294971)

# of Collaborated Projects: 20 results

# of Collaborated Products: 45 results
2. ODA Toshiaki (90126805)

# of Collaborated Projects: 16 results

# of Collaborated Products: 32 results
3. KITAGAWA Kyoko (20299605)

# of Collaborated Projects: 11 results

# of Collaborated Products: 2 results
4. HATTORI Takayuki (50377751)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. MIURA Satoshi (60157427)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. OHHATA Tatsuya (80616459)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. NIIDA Hiroyuki (20336671)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
8. 三浦直行 (40165965)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. YOKOTA Sadaki (40020755)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. NAKATA Takahiro (40273932)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 吉田進昭 (10250341)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 高山英次 (70533446)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 横尾宏毅 (30332894)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 杉山千歳 (00326125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 森下紗帆 (30614010)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 佐藤泰司 (10505267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 合田真 (70442960)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 堀口涼 (70452969)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 塩谷文章 (10627665)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
20. 松本雅記 (60380531)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 酒井聡 (50566081)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Uchida Chiharu 内田 千晴

UCHIDA Chiharu 内田 千晴

内田 千晴 ウチダ チハル

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Co-Researchers

がん抑制因子の機能不全によるDNA修復亢進とがん細胞の耐性獲得の機序Principal Investigator

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The tumor suppressor p130RB2 functions in replication stress response and suppression of chromosome instabilityPrincipal Investigator

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RB family functions in regulation of replication stress checkpointPrincipal Investigator

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Regulation of DNA replication and repair by ubiquitin or ubiquitin-like modification in cancer cellsPrincipal Investigator

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Degradation of the CDK inhibitor p27^<Kip1> by a novel ubiquitin ligase.Principal Investigator

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Uchida Chiharu 内田千晴

UCHIDA Chiharu 内田千晴

内田千晴ウチダチハル