OHTSU Hiroshi 大津浩

Researcher Number	60250742
External Links
Affiliation (based on the past Project Information) *help	2014 – 2016: 東北大学, 工学(系)研究科(研究院), 教授 2005 – 2006: 東北大学, 工学部, 教授 2003 – 2004: 東北大学, 大学院・工学研究科, 教授 2001 – 2002: Tohoku University, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 1999 – 2000: Sch. Of Med., Tohoku Univ., Lecturer, 大学院・医学系研究科, 講師 1998 – 1999: 東北大学, 医学部, 講師 1993 – 1997: 東北大学, 医学部, 助手
Review Section/Research Field	Principal Investigator General pharmacology / General pharmacology / Biological Sciences Except Principal Investigator General pharmacology / Neurochemistry/Neuropharmacology / Respiratory organ internal medicine / Psychiatric science / Respiratory organ internal medicine / 老化(加齢) / 応用薬理学・医療系薬学
Keywords	Principal Investigator ヒスチジン脱炭酸酵素 / ヒスタミン / histidine decarboxylase / 肥満細胞 / ノックアウトマウス / histamine / トランスジェニックマウス / transcription / cell specificity / mast cell … More / 転写因子 / 転写制御 / 胃酸分泌 / behavior / 遺伝子 / 行動 / methylation / メチル化 / 転写 / transcription factor / 細胞特異性 / 血球分化 / アレルギー / Gastric juice secrestion / Central nervous system / Bronchial asthma / Transgenic mice / Wound healing / L-histidine decarboxylase / Knockout mice / Histamine / 中枢神経 / 気管支喘息 / トランジェニックマウス / 創傷治癒 / allergy / infection / gene / transgenic mice / knockout mice / SAGE法 / H2受容体 / 概日リズム / 感染 / demethylation / promoter / mast cells / 脱メチル化 / プロモーター / allergic reaction / knockout mouse / transgenic mouse / 行動薬理 / 眼電位図 / レスキュー / アレルギー反応 / basophil / DNase I / CpG配列 / DNase I高感受性領域 / 組織特異性 / 好塩期球 / DNase1 / 好塩基球 / DNaseI / transcription facter / hematopoictic cell / differantiation / ルシフェラーゼ / 融合遺伝子 / 薬剤スクリーニング / transcriptional regulation / differentiation of hematopoietic cells / ビスチジン脱炭酸酵素 / 蛍光 / レポーターマウス / ヒスタミン産生細胞 / HDC-KOマウス / ヒスチジン脱炭酸酵素(HDC) / ヘパリン / 表面抗原 / 細胞株 / 分化 / 炎症 / 免疫 / 転移 / 浸潤 / がん … More Except Principal Investigator ヒスタミン / ノックアウトマウス / ヒスチジン脱炭酸酵素 / PET / Histamine / ヒスタミンN-メチル基転移酵素 / H2受容体 / H1受容体 / GFP / 気管支喘息 / Knock-out mice / histidine decarboxylase / histamine / 遺伝子発現 / Aging / 肥満細胞 / 骨髄細胞 / トランスポーター / メタンフェタミン / 神経可塑性 / mouse / collagen / Bone marrow derived cells / fibroblast / remodeling / allergic airway inflammation / asthma / 粘膜線維化 / 気道リモデリング / 線維化 / コラーゲン沈着 / G-CSF / 骨髄キメラマウス / マウス / コラーゲン / 骨髄由来細胞 / 線維芽細胞 / リモデリング / アレルギー気道炎症 / 喘息 / Polymorphism / Schizophrenia / 逆耐性現象 / 覚醒剤精神病 / 遺伝子多型 / 精神分裂病 / knock-out mouse / allergic reaction / L-histidine decarboxylase / サイトカイン / ヒスチジン脱炭酸酵素(HDC) / 気道炎症 / L-ヒスチジン脱炭酸酵素(HDC) / アレルギー反応 / L-ヒスチジン脱炭酸酵素 / Brain functions / Histidine decarboxylase / H2 receptor / H1 receptor / 脳機能 / H_2受容体 / H_1受容体 / 遺伝子改変動物 / ヒスチジン脱炭素酵素 / transporter / knockout mice / HィイD23ィエD2 receptor / histamine N-methyltranferase / ヒスタミンN-メチルトランスフェラーゼ / ヒスチジン・デカルボキシラーゼ / ヒスタミンH3受容体 / ヒスチジン脳炭酸酵素 / ヒスタミンH_3受容体 / ヒスタミン・トランスポーター / H_3受容体 / ヒスタミンN-メチル基転位酵素 / mast cell / knockout mouse / gene expression / histamine N-methyltransferase / T細胞 / ヒスタミンヒスチジン脱炭酸酵素 / ノックアウトマウス / ヒスタミン N・メチル基転移酵素 / ヒステジン脱炭酸酵素 / H3 receptor / brain / human / Alzheimer disease / Histamine H1 receptor / ヒスタミンH-1受容体ノックアウトマウス / 老化促進マウス / 局所脳糖代謝率 / ヒト / ヒスタミンH_1受容体 / アルツハイマー病 / 脳の老化 / Convulsion / Learning-Memory / 加令 / 痙攣 / 学習・記憶 / ヒスチジン脱脳炭酸酵素 / メタンフエタミン / 逆耐性 / ヒスタミンの吸収 / 血液脳関門 / ヒスタミン欠陥マウス / 自発運動 / NO_2 / HMT阻害剤 / ヒスタミンN-メチル基転移酵素(HNT) / 喘息モデル / NOS / NO / 線状体 / 6-ヒドロキシドーパ / 物理的除神経 / 化学的除神経 / H3受容体 / ヒスタミン受容体 Less

トランスジェニックマウスを使ったヒスタミン産生細胞の病態解析Principal Investigator
- Principal Investigator
  
  大津浩
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Tohoku University
Analysis of bone-marrow derived fibroblasts involved in asthmatic airway remodeling and its interventional control of function
- Principal Investigator
  
  YAMAUCHI Kohei
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Iwate Medical University
Identification of histamine producing cells by the gene-rescue methodPrincipal Investigator
- Principal Investigator
  
  OHTSU Hiroshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Tohoku University
ヒスタミンによる肥満細胞分化制御機構Principal Investigator
- Principal Investigator
  
  大津浩
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Assessment of function of histamine using histidine decarboxylase gene-manupulated micePrincipal Investigator
- Principal Investigator
  
  OHTSU Hiroshi, 渡邉建彦
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Tohoku University
ヒスタミン・トランスポーターは、存在するか?ヒスタミン合成酵素KOマウスを用いた研究
- Principal Investigator
  
  渡邉建彦
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Tohoku University
The research of the regulation of transcription in histidine decarboxylase genePrincipal Investigator
- Principal Investigator
  
  OHTSU Hiroshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Tohoku University
ヒスタミンのがん浸潤・転移に及ぼす影響についてPrincipal Investigator
- Principal Investigator
  
  大津浩
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tohoku University
メタンフェタミン行動感作に中枢ヒスタミンが関与しているか?KOマウスを用いた研究
- Principal Investigator
  
  渡邉建彦
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Tohoku University
Role of brain histamine on refractory schizophrenia
- Principal Investigator
  
  ITO Chihiro, 佐藤光源
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Tohoku University
ヒスチジン脱炭酸酵素遺伝子ノックアウトマウスを用いたヒスタミンと神経可塑性の研究
- Principal Investigator
  
  渡邊建彦
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tohoku University
ヒスチジン脱炭酸酵素欠損マウスにおけるヒスタミンの由来:ヒスタミンの新規合成経路の可能性
- Principal Investigator
  
  渡邉建彦
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Tohoku University
Studies on Brain Histamine Neurons Using Gene-Targetted Mice
- Principal Investigator
  
  WATANABE Takehiko
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tohoku University
The discovery of new physiological effect of histamine by gene-manipulated mice and its application for the creation of pathological modelPrincipal Investigator
- Principal Investigator
  
  OHTSU Hiroshi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  TOHOKU UNIVERSITY
Analysis on the physiological role histamine in airway inflammation using knock-out mice
- Principal Investigator
  
  YAMAUCHI Kohei
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Iwate Medical University
ヒスタミン受容体および合成酵素のイックアウトマウスを用いた神経可塑性の研究
- Principal Investigator
  
  渡邊建彦
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
ヒスタミンの脳機能における役割の解明--国際学術共同研究をめざして
- Principal Investigator
  
  渡邉建彦
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tohoku University
ヒスタミンN-メチル基転移酵素の気道過敏症における役割:新規喘息治療薬の可能性
- Principal Investigator
  
  渡邉建彦
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tohoku University
Regulation of histamine synthesis and degradation at the gene level
- Principal Investigator
  
  WATANABE Takehiko
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  General pharmacology
- Research Institution
  Tohoku University
Molecular pharmacology of histamine system
- Principal Investigator
  
  WATANABE Takehiko
- Project Period (FY)
  1996 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General pharmacology
- Research Institution
  TOHOKU UNIVERSITY
Elucidation of the control mechanism of transcription of human L-histidine decarboxylase and trial of the control of histamine productionPrincipal Investigator
- Principal Investigator
  
  OHTSU Hiroshi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Tohoku University
神経可塑性におけるヒスタミンH3受容体
- Principal Investigator
  
  渡邉建彦
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
薬剤スクリーニングの簡素化-ヒト・ヒスチジン脱炭酸酵素Principal Investigator
- Principal Investigator
  
  OHTSTU Hiroshi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Tohoku University
The control of human histidine decarboxylase gene expression and elucidation of the regulatory mechanism of histamine synthesisPrincipal Investigator
- Principal Investigator
  
  OHTSU Hiroshi
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  TOHOKU UNIVERSITY SCHOOL OF MEDICINE
Imaging of neurotransmission in humnan brains : Normal and abnormal aging.
- Principal Investigator
  
  YANAI Kazuhiko
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  老化(加齢)
- Research Institution
  Tohoku University of Medicine
中枢ヒスタミンの遊離・合成の調節機構:前シナプス性H_3受容体のクローニング
- Principal Investigator
  
  WATANABE Takehiko
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
Histamine and learning-memory and convulsion
- Principal Investigator
  
  WATANABE Takehiko
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tohoku University Medical School

All 2016 2015 2014 2005 2004 2003

All Journal Article Presentation Book Patent

[Book] Handbook of Experimental Pharmacology2016
- Author(s)
  Hiroshi Ohtsu, Masahiro Seike
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-26460332
[Book] Handbook of Experimental Pharmacology ( Histamine and Histamine Receptors in Allergic Dermatitis.)2016
- Author(s)
  Ohtsu H, Seike M
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-26460332
[Journal Article] Deficiency of histidine decarboxylase attenuates peripheral nerve fibre elongation into the epidermis in surfactant-treated mouse skin.2016
- Author(s)
  Inami Y, Sato A, Ohtsu H, Mano Y, Sasaki A, Kuraishi Y, Andoh T.
- Journal Title
  
  Exp Dermatol.
  
  Volume: - Issue: 5 Pages: 441-443
- DOI
  10.1111/exd.13223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460332, KAKENHI-PROJECT-15K08667
[Journal Article] Effect of mineralocorticoid receptor antagonists on proteinuria and progression of chronic kidney disease: a systematic review and meta-analysis.2016
- Author(s)
  Currie G, Taylor AH, Fujita T, Ohtsu H, Lindhardt M, Rossing P, Boesby L, Edwards NC, Ferro CJ, Townend JN, van den Meiracker AH, Saklayen MG, Oveisi S, Jardine AG, Delles C, Preiss DJ, Mark PB.
- Journal Title
  
  BMC Nephrol.
  
  Volume: 17 Issue: 1 Pages: 127-140
- DOI
  10.1186/s12882-016-0337-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460332, KAKENHI-PROJECT-16K15494, KAKENHI-PROJECT-15H05788
[Journal Article] Crosstalk Between Histamine and T Cells in Allergic Disease.2016
- Author(s)
  Mayumi Saeki, Tomoe Nishimura, Osamu Kaminuma, Hiroshi Ohtsu, Akio Mori and Takachika Hiroi.
- Journal Title
  
  Current Immunology Reviews
  
  Volume: 12 Pages: 10-13
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460332
[Journal Article] Critical role of endogenous histamine in promoting end-organ tissue injury in sepsis.2016
- Author(s)
  Hattori M, Yamazaki M, Ohashi W, Tanaka S, Hattori K, Todoroki K, Fujimori T, Ohtsu H, Matsuda N, Hattori Y.
- Journal Title
  
  Intensive Care Med Exp.
  
  Volume: ４ Issue: 1 Pages: 36-44
- DOI
  10.1186/s40635-016-0109-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460332, KAKENHI-PROJECT-15K19319, KAKENHI-PROJECT-16K08200, KAKENHI-PROJECT-16K08231
[Journal Article] Histamine regulation of microglia: Gene-environment interaction in the regulation of central nervous system inflammation.2016
- Author(s)
  Frick L, Rapanelli M, Abbasi E, Ohtsu H, Pittenger C.
- Journal Title
  
  Brain Behav Immun.
  
  Volume: 57 Pages: 326-337
- DOI
  10.1016/j.bbi.2016.07.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460332
[Journal Article] High-amplitude theta wave bursts characterizing narcoleptic mice and patients are also produced by histamine deficiency in mice.2016
- Author(s)
  Bastianini S, Lo Martire V, Berteotti C, Silvani A, Ohtsu H, Lin JS, Zoccoli G.
- Journal Title
  
  J Sleep Res.
  
  Volume: 25 Issue: 5 Pages: 591-595
- DOI
  10.1111/jsr.12404
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460332
[Journal Article] Mast cell histamine-mediated transient inflammation following exposure to nickel promotes nickel allergy in mice2016
- Author(s)
  Kinbara M, Bando K, Shiraishi D, Kuroishi T, Nagai Y, Ohtsu H, Takano-Yamamoto T, Sugawara S, Endo Y
- Journal Title
  
  Exp Dermatol.
  
  Volume: 印刷中 Issue: 6 Pages: 466-71
- DOI
  10.1111/exd.12985
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K20578, KAKENHI-PROJECT-15H05048, KAKENHI-PROJECT-26460332, KAKENHI-PROJECT-16K11672, KAKENHI-PROJECT-16K20638
[Journal Article] Histidine decarboxylase knockout mice, a genetic model of Tourette syndrome, show repetitive grooming after induced fear.2015
- Author(s)
  Xu M, Li L, Ohtsu H, Pittenger C.
- Journal Title
  
  Neurosci Lett.
  
  Volume: 595 Pages: 50-53
- DOI
  10.1016/j.neulet.2015.03.067
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460332
[Journal Article] Protective effect of carnosine on febrile seizures in immature mice.2015
- Author(s)
  Dai Y, Wu D, Feng B, Hou W, Xu C, Ohtsu H, Chen Z, Hu W.
- Journal Title
  
  Neurosci Lett
  
  Volume: 588 Pages: 95-100
- DOI
  10.1016/j.neulet.2014.12.061
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460332
[Journal Article] Large particulate allergens can elicit mast cell-mediated anaphylaxis without exit from blood vessels as efficiently as do small soluble allergens2015
- Author(s)
  LiHua Li, Takuya Ohta, Kayo Horiguchi, Yohei Kawano, Hiroshi Ohtsu, Yoshinori Yamanishi, MD., Hajime Karasuyama.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 467 Issue: 1 Pages: 70-75
- DOI
  10.1016/j.bbrc.2015.09.120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460332, KAKENHI-PROJECT-15K20969, KAKENHI-PROJECT-15H05786, KAKENHI-PROJECT-15H02515
[Journal Article] Histamine Promotes Locomotion Recovery After Spinal Cord Hemisection via Inhibiting Astrocytic Scar Formation.2015
- Author(s)
  Zhao YY, Yuan Y, Chen Y, Jiang L, Liao RJ, Wang L, Zhang XN, Ohtsu H, Hu WW, Chen Z.
- Journal Title
  
  CNS Neurosci. Ther
  
  Volume: 21 Issue: 5 Pages: 454-62
- DOI
  10.1111/cns.12379
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460332
[Journal Article] Histamine suppresses regulatory T cells mediated by TGF-β in murine chronic allergic contact dermatitis.2015
- Author(s)
  Kyoko Tamaka, Masahiro Seike, Tamio Hagiwara, Atsushi Sato, Hiroshi Ohtsu.
- Journal Title
  
  Exp Dermatol
  
  Volume: 24 Issue: 4 Pages: 280-284
- DOI
  10.1111/exd.12644
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460332
[Journal Article] The role of histamine in the retina, studies on the HDC knockout mouse.2015
- Author(s)
  U Greferath, KA Vessey, AI Jobling, SA Mills, BV Bui, Z He, H Ohtsu , EL Fletcher.
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 12 Pages: e116025-e116025
- DOI
  10.1371/journal.pone.0116025
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460332
[Journal Article] Histamine Transmission Modulates the Phenotype of Murine Narcolepsy Caused by Orexin Neuron Deficiency2015
- Author(s)
  Stefano Bastianini; Alessandro Silvani; Chiara Berteotti; Viviana Lo Martire; Gary Cohen; Hiroshi Ohtsu; Jian-Sheng Lin; Giovanna Zoccoli.
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 10 Pages: e0140520-e0140520
- DOI
  10.1371/journal.pone.0140520
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460332
[Journal Article] Close relationship between T helper (Th)17 and Th2 response in murine allergic contact dermatitis.2014
- Author(s)
  A. Matsushita, M. Seike, T. Hagiwara, A. Sato and H. Ohtsu
- Journal Title
  
  Clin Exp Dermatol
  
  Volume: 39 Issue: 8 Pages: 924-931
- DOI
  10.1111/ced.12425
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460332
[Journal Article] Histidine decarboxylase deficiency causes Tourette syndrome: parallel findings in humans and mice.2014
- Author(s)
  L C Baldan, K A. Williams, J-D Gallezot, V Pogorelov, M Rapanelli, M Crowley, GM. Anderson, E Loring, R Gorczyca, E Billingslea, S Wasylink, KE. Panza, A. G Ercan-Sencicek, K Krusong, B L. Leventhal, Ohtsu, ZA. Hughes, JH. Krystal, Linda Mayes, I de Araujo, Y-S Ding, MW. State, C Pittenger.
- Journal Title
  
  Neuron
  
  Volume: 81 Issue: 1 Pages: 77-90
- DOI
  10.1016/j.neuron.2013.10.052
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460332
[Journal Article] Roles of histamine on the expression of aldehyde dehydrogenase 1 in endometrioid adenocarcinoma cell line.2014
- Author(s)
  Wang Y, Jiang Y, Ikeda J, Tian T, Sato A, Ohtsu H, Morii E .
- Journal Title
  
  Cancer Medicine
  
  Volume: 3 Issue: 5 Pages: 1126-1135
- DOI
  10.1002/cam4.296
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-25108507, KAKENHI-PROJECT-25460435, KAKENHI-PROJECT-26460332, KAKENHI-PROJECT-26460470
[Journal Article] Histamine H3 Receptors Aggravate Cerebral Ischemic Injury by Histamine-independent Mechanisms.2014
- Author(s)
  Haijing Yan, Xiangnan Zhang, Weiwei Hu, Jing Ma, Weiwei Hou, Xingzhou Zhang, Xiaofen Wang, Jieqiong Gao, Yao Shen, Jianxin Lu, Hiroshi Ohtsu, Feng Han, Guanghui Wang, and Zhong Chen.
- Journal Title
  
  Nature Communications
  
  Volume: 5 Issue: 1 Pages: 33334-33334
- DOI
  10.1038/ncomms4334
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460332
[Journal Article] Dysregulated intracellular signaling in the striatum in a pathophysiologically grounded model of Tourette syndrome.2014
- Author(s)
  Maximiliano Rapanelli, Luciana R. Frick, Vladimir Pogorelov, Kristie T. Ota, Eeman Abbasi, Hiroshi Ohtsu, Christopher Pittenger.
- Journal Title
  
  European Neuropsychopharmacology
  
  Volume: 24 Issue: 12 Pages: 1896-1906
- DOI
  10.1016/j.euroneuro.2014.10.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460332
[Journal Article] Histamine synthesis is required for granule maturation in murine mast cells.2014
- Author(s)
  Nakazawa, S., Sakanaka, M., Furuta, K., Natsuhara, M., Takano, H., Tsuchiya, S., Okuno, Y., Ohtsu, H., Nishibori, M., Thurmond, R.L., Hirasawa, N., Nakayama, K., Ichikawa, A., Sugimoto, Y., and Tanaka, S.
- Journal Title
  
  Eur. J. Immunol.
  
  Volume: 44 Issue: 1 Pages: 204-214
- DOI
  10.1002/eji.201343838
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22116001, KAKENHI-PROJECT-23590077, KAKENHI-PROJECT-23659044, KAKENHI-PUBLICLY-25113514, KAKENHI-PROJECT-25860049, KAKENHI-PROJECT-26460332
[Journal Article] The role of histamine in goblet cell hyperplasia in allergic airway inflammation-A study using the HDC knockout mouse-.2005
- Author(s)
  Piao H-M, Yamauchi K, Nakamura Y, Nakadate T, Ito H, Mouri T, Kobayashi H, Ohtsu H, Inoue H
- Journal Title
  
  Proceeding of the 6th Asia Pacific Congress of Allergology and Clinical Immunology : 2004, October 4-7.Tokyo : Monduzzi Editore
  
  Pages: 193-195
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590802
[Patent] 肥満モデル動物およびそれを用いた薬剤評価方法2004
- Inventor(s)
  岡部進, 市川厚, 大津浩
- Industrial Property Rights Holder
  天藤製薬株式会社大槻良三
- Industrial Property Number
  2004-094769
- Filing Date
  2004-03-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390076
[Patent] 形質転換不死化細胞株の樹立方法とその細胞株2003
- Inventor(s)
  大津浩, 帯刀益夫
- Industrial Property Rights Holder
  科学技術振興事業団
- Industrial Property Number
  2003-045518
- Filing Date
  2003-02-24
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390076
[Presentation] 産学連携による福祉機器の開発2015
- Author(s)
  大津　浩
- Organizer
  日本褥瘡学会
- Place of Presentation
  仙台国際会議場（宮城県、仙台市）
- Year and Date
  2015-08-28
- Invited
- Data Source
  KAKENHI-PROJECT-26460332
[Presentation] New findings of a histamine-related pathological phenomenon and its therapeutic application2015
- Author(s)
  大津　浩
- Organizer
  日本薬理学会
- Place of Presentation
  名古屋国際会議場（愛知県、名古屋市）
- Year and Date
  2015-03-18
- Data Source
  KAKENHI-PROJECT-26460332

1. WATANABE Takehiko (70028356)

# of Collaborated Projects: 16 results

# of Collaborated Products: 0 results
2. YANAI Kazuhiko (50192787)

# of Collaborated Projects: 10 results

# of Collaborated Products: 0 results
3. KARAMASU Atsuo (90302091)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
4. YAMAUCHI Kohei (20200579)

# of Collaborated Projects: 6 results

# of Collaborated Products: 1 results
5. WATANABE Takeshi (40028684)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. MAEYAMA Kazutaka (00157158)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. ITO Chihiro (60292330)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. 桜井映子

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. YAMATODANI Atsushi (30116123)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. HIRASAWA Noriyasu (80181155)

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# of Collaborated Products: 0 results
11. ICHIKAWA Atsushi (10025695)

# of Collaborated Projects: 2 results

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12. TERUI Tadashi (30172109)

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13. 佐藤光源 (70033321)

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14. FALUS Andras

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15. NAGY Andras

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16. ONODERA Kinji (40133988)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. MEGURO Kenichi (90239559)

# of Collaborated Projects: 1 results

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18. UENO Hiroshi (30241160)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. KUBOTA Yasuhiko (90333799)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. MURAI Kazunori (70285592)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 石井邦明 (10184459)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 安藤健二郎 (40261614)

# of Collaborated Projects: 1 results

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23. 古山和道 (80280874)

# of Collaborated Projects: 1 results

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24. YATSUNAMI Kimio

# of Collaborated Projects: 1 results

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25. YAMADA Noboru

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. SAKURAI Eiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 佐々木雅幸

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. ナギーアンドラス

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. ANDRAS Nagy

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. ANDRAS Falus

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. IKEDA Junichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 杉本幸彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 金原正敬

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OHTSU Hiroshi 大津 浩

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トランスジェニックマウスを使ったヒスタミン産生細胞の病態解析Principal Investigator

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Identification of histamine producing cells by the gene-rescue methodPrincipal Investigator

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ヒスタミンによる肥満細胞分化制御機構Principal Investigator

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Assessment of function of histamine using histidine decarboxylase gene-manupulated micePrincipal Investigator

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The research of the regulation of transcription in histidine decarboxylase genePrincipal Investigator

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ヒスタミンのがん浸潤・転移に及ぼす影響についてPrincipal Investigator

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The discovery of new physiological effect of histamine by gene-manipulated mice and its application for the creation of pathological modelPrincipal Investigator

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OHTSU Hiroshi 大津浩