Yamashita Hirofumi 山下博史

… Alternative Names

YAMASHITA Hirofumi 山下博史

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Researcher Number	60402913
Other IDs
Affiliation (Current)	2025: 日本赤十字社和歌山医療センター(臨床研究センター), 脳神経内科部, 部長 2025: 京都大学, 医学研究科, 助教
Affiliation (based on the past Project Information) *help	2017: 京都大学, 医学研究科, 講師 2015: 京都大学, 医学研究科, 講師 2012 – 2014: 京都大学, 医学(系)研究科(研究院), 助教 2011: 独立行政法人理化学研究所, 運動ニューロン変性研究チーム, 研究員 2010 – 2011: 京都大学, 医学研究科, 助教 2009: The Institute of Physical and Chemical Research, 運動ニューロン変性研究チーム, 研究員 2008: The Institute of Physical and Chemical Research, 山中研究ユニット, 研究員
Review Section/Research Field	Principal Investigator Neurology Except Principal Investigator Neurology / Biological Sciences
Keywords	Principal Investigator ミクログリア / 筋萎縮性側索硬化症 / 神経変性疾患 / マイクロアレイ / マイクログリア / グリア / 遺伝子 / 自然免疫 / トランスクリプトーム / アストロサイト … More / 筋委縮性側索硬化症 / 貪食 / 神経病態生化学 / 非自律的神経細胞死 / マトリックスメタロプロテアーゼ / SOD1 … More Except Principal Investigator 神経変性疾患 / グリア / 筋萎縮性側索硬化症 / ALS / アストロサイト / 細胞外環境 / 脊髄 / 脊髄環境 / 環境 / グリア細胞 / ミクログリア / 神経病態生化学 Less

Elucidating pathomechanism of ALS through the abnormality in astrocytes
- Principal Investigator
  
  YAMANAKA Koji
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
Microarray analysis in spinal cords of sporadic ALS patients with cell-type specific transcriptomePrincipal Investigator
- Principal Investigator
  
  YAMASHITA Hirofumi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyoto University
Spinal cord environment: elucidating the mechanism of neurodegeneration through glia-neuron interaction
- Principal Investigator
  
  Yamanaka Koji
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
  The Institute of Physical and Chemical Research
Evaluation of phagocytic function and analysis of antigen-processing mechanism of microglia in ALSPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Hirofumi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Kyoto University
Elucidating molecular pathology of glial cells in amyotrophic lateral sclerosis
- Principal Investigator
  
  YAMANAKA Koji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  The Institute of Physical and Chemical Research
Unraveling the mechanism of the non-cell autonomous neuronal cell death in amyotroohic lateral sclerosisPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Hirofumi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  The Institute of Physical and Chemical Research
A role of microglia in Amyotrophic Lateral Sclerosis
- Principal Investigator
  
  YAMANAKA Koji
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  The Institute of Physical and Chemical Research

All 2017 2015 2014 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation Book

[Book] 分子脳科学2015
- Author(s)
  山下博史・漆谷真・高橋良輔（三品　昌美　編）
- Total Pages
  312
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-24591259
[Book] 医学のあゆみ(遺伝子改変によるALSモデルマウス)2015
- Author(s)
  山下博史、漆谷真
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-24591259
[Book] medicina(筋萎縮～特徴的な所見と検査)2014
- Author(s)
  山下博史,髙橋良輔
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-24591259
[Book] 脳神経科学イラストレイテッド　改訂第3版「ALSなど運動ニューロン病」の章2013
- Author(s)
  山下博史、髙橋良輔
- Total Pages
  395
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-24591259
[Book] 脳神経科学イラストレイテッド　改訂第3版2013
- Author(s)
  山下博史、髙橋良輔
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-24591259
[Journal Article] Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant2014
- Author(s)
  Ayaki T, Ito H, Fukushima H, Inoue T, Kondo T, Ikemoto A, Asano T, Shodai A, Fujita T, Fukui S, Morino H, Nakano S, Kusaka H, Yamashita H, Ihara M, Matsumoto R, Kawamata J, Urushitani M, Kawakami H, Takahashi R.
- Journal Title
  
  Acta Neuropathol Commun.
  
  Volume: 2 Issue: 1 Pages: 172-185
- DOI
  10.1186/s40478-014-0172-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591259, KAKENHI-PROJECT-25860711, KAKENHI-PROJECT-26282218, KAKENHI-PROJECT-26290023, KAKENHI-PROJECT-26560465, KAKENHI-PLANNED-23111002
[Journal Article] A novel mutation in <i>glycyl-tRNA synthetase</i> caused Charcot-Marie-Tooth disease type 2D with facial and respiratory muscle involvement2014
- Author(s)
  N. Kawakami, K. Komatsu, H. Yamashita, K. Uemura,N.Oka, H. Takashima, and R. Takahashi
- Journal Title
  
  Rinsho Shinkeigaku
  
  Volume: 54 Issue: 11 Pages: 911-915
- DOI
  10.5692/clinicalneurol.54.911
- NAID
  130004706051
- ISSN
  0009-918X, 1882-0654
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591259
[Journal Article] Optineurin suppression causes neuronal cell death via NF-κB pathway.2013
- Author(s)
  Akizuki M, Yamashita H, Uemura K, Maruyama H, Kawakami H, Ito H, Takahashi R.
- Journal Title
  
  J Neurochem
  
  Volume: 126(6) Issue: 6 Pages: 2230-41
- DOI
  10.1111/jnc.12326
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002, KAKENHI-PLANNED-23111008, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23591246, KAKENHI-PROJECT-24300132, KAKENHI-PROJECT-24591259
[Journal Article] ALS病態におけるグリアの役割2012
- Author(s)
  山下博史、山中宏二
- Journal Title
  
  脳21
  
  Volume: 15 Pages: 28-33
- Data Source
  KAKENHI-PLANNED-23111006
[Journal Article] ALS病態におけるグリアの役割2012
- Author(s)
  山下博史、山中宏二
- Journal Title
  
  脳21
  
  Volume: 15 Pages: 28-33
- Data Source
  KAKENHI-PROJECT-22790834
[Journal Article] ALS病態におけるグリアの役割2012
- Author(s)
  山下博史,山中宏二
- Journal Title
  
  脳21
  
  Volume: 15 Pages: 28-33
- Data Source
  KAKENHI-PROJECT-21390274
[Journal Article] ALS-SOD1の発症機序2011
- Author(s)
  山下博史,山中宏二
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 29 Pages: 1044-1045
- Data Source
  KAKENHI-PROJECT-21390274
[Journal Article] ALS-SOD1の発症機序2011
- Author(s)
  山下博史、山中宏二
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 29 Pages: 1044-1045
- Data Source
  KAKENHI-PROJECT-22790834
[Journal Article] Down-regulation of secrete d lymphocyte antigen-6/urokinase-type pl asminogen activator-related peptide-1(SLURP-1), an endogenous allosteric & 7nic otinic acetylcholine receptor modulator, i n murine and human asthmatic conditio ns2010
- Author(s)
  Narumoto O., 他5名, Misawa H., Ya mashita N., Nagase T., Kawashima K., Yamashita N
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 398 Pages: 713-718
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390274
[Journal Article] Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis2008
- Author(s)
  Yamanaka K, Chun SJ, Boillee S, Fujimori-Tonou N, Yamashita H, Gutmann DH, Misawa H, Takahashi R, & Cleveland DW.
- Journal Title
  
  Nat. Neurosci. 11
  
  Pages: 251-253
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591021
[Journal Article] ALSとミクログリア: 非細胞自律性の神経細胞死2007
- Author(s)
  山中宏二、山下博史
- Journal Title
  
  Brain and Nerve 59
  
  Pages: 1163-1170
- Data Source
  KAKENHI-PROJECT-19591021
[Journal Article] Heat-shock protein 105 interacts with and suppresses aggregation of mutant Cu/Zn superoxide dismutase;clues to a possible strategy for treating ALS.2007
- Author(s)
  Hirofumi Yamashita, et. al.
- Journal Title
  
  Journal of Neurochemistry 102
  
  Pages: 1497-1505
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591021
[Presentation] Innate immune adaptor TRIF slows disease progression of ALS mice by eliminating aberrantly activated astrocytes.2017
- Author(s)
  Komine O, Yamashita H. Fujimori-Tonou N, Uematsu S, Akira S, Yamanaka K.
- Organizer
  28th International symposium on ALS/MND
- Data Source
  KAKENHI-PROJECT-26293208
[Presentation] ALSモデルマウスにおける自然免疫TRIF経路の役割2015
- Author(s)
  小峯　起、山下博史、藤森典子、森脇康博、三澤日出巳、山中宏二
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PLANNED-23111006
[Presentation] Microarray analysis in spinal cords of sporadic ALS patients with cell-type specific transcriptome2014
- Author(s)
  Hirofumi Yamashita 、 Noriko Fujimori 、 Hidefumi Ito 、Yohei Iguchi 、Naoki Atsuta 、 Fumiaki Tanaka 、Gen Sobue 、 Ryosuke Takahashi 、Koji Yamanaka
- Organizer
  Nucleic Acid Summit
- Place of Presentation
  San Diego,U.S.A.
- Year and Date
  2014-06-19
- Data Source
  KAKENHI-PROJECT-24591259
[Presentation] Microarray analysis in spinal cords of sporadic ALS patients with cell-type specific transcriptome2014
- Author(s)
  Hirofumi Yamashita, Okiru komine, Noriko Fujimori, Hidefumi Ito, Yohei Iguchi, Naoki Atsuta, Fumiaki Tanaka, Gen Sobue, Ryosuke Takahashi, Koji Yamanaka
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-13
- Data Source
  KAKENHI-PROJECT-24591259
[Presentation] Optineurin suppression causes neuronal cell death via NF-κB pathway2014
- Author(s)
  Akizuki M1, Yamashita H, Uemura K, Maruyama H, Kawakami H, Ito H, Takahashi R.
- Organizer
  14th Asian & Oceanian Congress of Neurology
- Place of Presentation
  Macau
- Data Source
  KAKENHI-PROJECT-24591259
[Presentation] NF-κB経路を介したOptineurinのノックダウンによる神経細胞死2013
- Author(s)
  秋月真由美、山下博史、植村健吾、丸山博文、川上秀文、伊東秀文、髙橋良輔
- Organizer
  第22回　日本Cell death学会
- Place of Presentation
  京都　京都大学
- Data Source
  KAKENHI-PROJECT-24591259
[Presentation] NF-κB経路を介したOptineurinのノックダウンによる神経細胞死2013
- Author(s)
  秋月真由美、山下博史、植村健吾、丸山博文、川上秀文、伊東秀文、髙橋良輔
- Organizer
  Neuro2013
- Place of Presentation
  京都　国際会議場
- Data Source
  KAKENHI-PROJECT-24591259
[Presentation] 細胞特異的トランスクリプトームを用いた、弧発性ALS患者脊髄のDNAマイクロアレイによる解析2012
- Author(s)
  山下博史、藤森典子、片岡礼音、井口洋平、熱田直樹、田中章景、祖父江元、山中宏二
- Organizer
  第52回日本神経学会学術大会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2012-05-18
- Data Source
  KAKENHI-PROJECT-22790834
[Presentation] Microarray Analysis in Spinal Cords of Sporadic ALS Patients with Cell-Type Specific Transcriptome.2012
- Author(s)
  Hirofumi Yamashita et al.
- Organizer
  American Academy of Neurology 64th Annual Meeting
- Place of Presentation
  New Orleans, USA
- Year and Date
  2012-04-21
- Data Source
  KAKENHI-PLANNED-23111006
[Presentation] 細胞特異的トランスクリプトームを用いた、弧発性ALS患者脊髄のDNAマイクロアレイによる解析2011
- Author(s)
  山下博史
- Organizer
  第52回日本神経学会学術大会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2011-05-18
- Data Source
  KAKENHI-PROJECT-22790834
[Presentation] 細胞特異的トランスクリプトームを用いた、弧発性ALS患者脊髄のDNAマイクロアレイによる解析2011
- Author(s)
  山下博史
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-22790834
[Presentation] 細胞特異的トランスクリプトームを用いた孤発性ALS患者脊髄のDNAマイクロアレイによる解析2011
- Author(s)
  山下博史, 他10名
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PLANNED-23111006
[Presentation] 細胞特異的トランスクリプトームを用いた孤発性ALS患者脊髄のDNAマイクロアレイによる解析2011
- Author(s)
  山下博史, 他7名
- Organizer
  第52回日本神経学会学術大会
- Place of Presentation
  名古屋
- Year and Date
  2011-05-18
- Data Source
  KAKENHI-PROJECT-21390274
[Presentation] 細胞特異的トランスクリプトームを用いた、弧発性ALS患者脊髄のDNAマイクロアレイによる解析2011
- Author(s)
  山下博史
- Organizer
  包括型脳科学研究推進支援ネットワーク「夏のワークショップ」
- Place of Presentation
  神戸国際会議場
- Year and Date
  2011-08-22
- Data Source
  KAKENHI-PROJECT-22790834
[Presentation] 変異SOD1発現マイクログリアにおける貪食機能の評価2010
- Author(s)
  山下博史
- Organizer
  日本神経学会総会
- Place of Presentation
  東京都・東京国際フォーラム
- Year and Date
  2010-05-22
- Data Source
  KAKENHI-PROJECT-22790834
[Presentation] 変異SOD1発現マイクログリアにおける貪食機能の評価2010
- Author(s)
  山下博史, 他
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京
- Year and Date
  2010-05-22
- Data Source
  KAKENHI-PROJECT-21390274
[Presentation] 変異SOD1発現マイクログリアにおける貪食機能の評価2010
- Author(s)
  山下博史、藤森典子、片岡礼音、山中宏二
- Organizer
  第51回日本神経学会学術大会
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2010-05-22
- Data Source
  KAKENHI-PROJECT-22790834
[Presentation] 細胞特異的トランスクリプトームを用いたALSマウス脊髄のDNAマイクロアレイによる解析2009
- Author(s)
  山下博史, 藤森典子, 渡辺祥司, 山中宏二
- Organizer
  第50回日本神経学会総会
- Place of Presentation
  仙台国際センター
- Year and Date
  2009-05-20
- Data Source
  KAKENHI-PROJECT-20790630
[Presentation] 細胞特異的トランスクリプトームを用いたALSマウス脊髄D NAマイクロアレイの解析2009
- Author(s)
  山下博史, 他3名
- Organizer
  第50回日本神経学会総会
- Place of Presentation
  仙台
- Year and Date
  2009-05-20
- Data Source
  KAKENHI-PROJECT-21390274
[Presentation] 細胞特異的トランスクリプトームを用いたALSマウス脊髄DNAマイクロアレイの解析2009
- Author(s)
  山下博史, 山中宏二, 他
- Organizer
  第50回日本神経学会総会
- Place of Presentation
  仙台
- Year and Date
  2009-05-20
- Data Source
  KAKENHI-PROJECT-21390274
[Presentation] 細胞特異的トランスクリプトームを用いたALSマウス脊髄DNAマイクロアレイの解析2009
- Author(s)
  山下博史
- Organizer
  第50回日本神経学会総会
- Place of Presentation
  仙台国際センター(宮城県仙台市)
- Year and Date
  2009-05-20
- Data Source
  KAKENHI-PROJECT-20790630
[Presentation] Microarray analysis in spinal cords of sporadic ALS patients with cell-type specific transcriptome
- Author(s)
  山下博史
- Organizer
  23rd international symposium on ALS/MND
- Place of Presentation
  Sheraton Cicago Hotel & Towers, Cicago, Illinois, USA
- Data Source
  KAKENHI-PROJECT-24591259
[Presentation] Microarray analysis in spinal cords of sporadic ALS patients with cell-type specific transcriptome
- Author(s)
  山下博史
- Organizer
  The 13th　Asian Oceanian Congress of Neurology
- Place of Presentation
  Melbourne Convention and Exhibition Centre, Melbourne, Australia
- Data Source
  KAKENHI-PROJECT-24591259
[Presentation] Microarray analysis in spinal cords of sporadic ALS patients with cell-type specific transcriptome
- Author(s)
  山下博史
- Organizer
  The 64th Annual Meeting of the American Academy of Neurology
- Place of Presentation
  Morial Convention Cente, New Orleans, Louisiana, USA
- Data Source
  KAKENHI-PROJECT-24591259

1. YAMANAKA Koji (80446533)

# of Collaborated Projects: 5 results

# of Collaborated Products: 10 results
2. MISAWA Hidemi (80219617)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
3. KOMINE Okiru (00456211)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. WATANABE Seiji (70633577)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. ENDO Fumito (10713307)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. KUROKAWA Yoichi (40326088)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. WATANABE Shoji (80462745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MORIWAKI Yasuhiro (00392150)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. Suzumura Akio (50196896)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Takeuchi Hideyuki (30362213)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Takahashi Ryosuke (90216771)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 高橋英機 (40446521)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 内匠透 (00222092)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. FUJIMORI Noriko

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. 川上秀史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamashita Hirofumi 山下 博史

YAMASHITA Hirofumi 山下 博史

Research Projects

Research Products

Co-Researchers

Elucidating pathomechanism of ALS through the abnormality in astrocytes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Microarray analysis in spinal cords of sporadic ALS patients with cell-type specific transcriptomePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Spinal cord environment: elucidating the mechanism of neurodegeneration through glia-neuron interaction

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluation of phagocytic function and analysis of antigen-processing mechanism of microglia in ALSPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidating molecular pathology of glial cells in amyotrophic lateral sclerosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Unraveling the mechanism of the non-cell autonomous neuronal cell death in amyotroohic lateral sclerosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A role of microglia in Amyotrophic Lateral Sclerosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 分子脳科学2015

Author(s)

Total Pages

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Data Source

[Book] 医学のあゆみ(遺伝子改変によるALSモデルマウス)2015

Author(s)

Publisher

Data Source

[Book] medicina(筋萎縮～特徴的な所見と検査)2014

Author(s)

Publisher

Data Source

[Book] 脳神経科学イラストレイテッド 改訂第3版 「ALSなど運動ニューロン病」の章2013

Author(s)

Total Pages

Publisher

Data Source

[Book] 脳神経科学イラストレイテッド 改訂第3版2013

Author(s)

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[Journal Article] Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant2014

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[Journal Article] A novel mutation in <i>glycyl-tRNA synthetase</i> caused Charcot-Marie-Tooth disease type 2D with facial and respiratory muscle involvement2014

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Yamashita Hirofumi 山下博史

YAMASHITA Hirofumi 山下博史

[Book] 脳神経科学イラストレイテッド　改訂第3版「ALSなど運動ニューロン病」の章2013

[Book] 脳神経科学イラストレイテッド　改訂第3版2013