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OHNO Ryuzo  大野 竜三

ORCIDConnect your ORCID iD *help
Researcher Number 70093002
Affiliation (based on the past Project Information) *help 2000: 愛知県がんセンター, 病院長
1997 – 1999: 浜松医科大学, 教授
1993 – 1999: 浜松医科大学, 医学部, 教授
1992: 名古屋大学, 医学部・附属病院分院, 助教授
1989 – 1992: 名古屋大学, 医学部, 助教授
1987 – 1988: 名古屋大学, 医学部, 講師
1986: Nagoya University School of Medicine, 医学部, 講師
Review Section/Research Field
Principal Investigator
Hematology
Except Principal Investigator
Hematology / Biological Sciences / 老化(加齢)
Keywords
Principal Investigator
急性前骨髄球性白血病 / 分化誘導療法 / レチノイン酸 / MEG-01 / Am-80 / PML / all-trans retinoic acid / 急性白血病 / 分子生物学 / PML遺伝子 … More / RAR遺伝子 / TPA / Megakaryocyte / Megakaryoblastic cell line / 細胞培養株 / 骨髄巨核球 / 骨髄巨核芽球細胞株 / matched-pair analysis / JALSG / IIIa / CD38 / CD34 / thrombopoietin receptor / erythropoietin receptor / MDS / acute promyelocytic leukemia / As_2O_3 / 化学療法 / MDR1 / レチノイドアンタゴニスト / 細胞内レチノイン酸結合蛋白 / 白血病 / 急性リンパ性白血病 / 多剤耐性遺伝子 / 薬剤耐性 / C-fos / C-myc / Phorbol esters / Differentiation induction / Oncogene / Culture cell line / c-sis / c-fos / c-myc / phorbol esters;TPA,分化誘導 / cーsis / cーfos / cーmyc / 分化誘導 / phorbol esters / 分化 / がん遺伝子 / MEGー01 / <beta> -thromboglobulin / Protein S / Coagulation factor / culture cell line / 単クローン抗体 / β-thromboglobulin / プロテインS / 凝固因子 / meta-analysis / differentiation therapy / bone marrow transplantation / chemotherapy / acute leukemia / MRC / IBMTR / メタアナリス / 急性骨髄性白血病 / メタアナリシス / マッチドペアアナリシス / 骨髄移植療法 / glycoprotein IIb / glycophorin A / Glycophorin-A / エリスロポイエチンレセプター / Glycoprotein IIb / Glycophorin A / 骨髄異形成症候群 / cytoplasmic retinoic acid binding protein / retinoid / apoptosis / Vitamin A / アポトーシス / 癌瘍1号-713 / PML-RARαキメラ遺伝子 / FAB classification / Chemotherapy / Hannover Medical School / University of Munster / Cooperative study / Leukemia / Federal Republic of Germany / 治療戦略 / ハノ-バ-大学 / ミュンスタ-大学 / 共同研究 / ドイツ連邦共和国 / Phenotypic change / Drug resistance / Retroviral vector / Hematopoietic stem cells / P-glycoprotin / Multidrug resistant gene / Gene transfection / PSVLベクタ- / CFU / 骨髄幹細胞 / mdr / 形質転換 / 形貭転換 / レトロウイルスベクタ- / 造血幹細胞 / Pー糖蛋白 / 遺伝子導入 / 亜砒酸 / RARA / トランスジェニック・マウス / ユビキチン・プロテアゾーム / ブファリン / ポリプレン酸 / レチノイン酸レセプター / レチノイド / 分子誘導療法 / 急性前骨髄性白血病 / レチノイン酸受容体 / 分子マ-カ- / CDR3 / 微量残存腫瘍 / 免疫グロブリン遺伝子 / cALL / ヌードマウス / 白血病細胞株 / mdr1 / 多剤耐性 … More
Except Principal Investigator
急性前骨髄球性白血病 / NB4 / 急性骨髄性白血病 / 薬剤耐性 / シスプラチン耐性 / 多剤耐性 / P-glycoprotein / All-trans Retinoic Acid (ATRA)-Resistance / Acute Promyelocytic Leukemia / 全トランス型レチノイン酸 / P糖蛋白 / 全トランス型レチノイン酸耐性 / Antisense nucleotide / myeloid differentiation / Acute myeloid leukemia / Homeobox Box gene / 骨髄性白血病 / ホメオボックス遺伝子 / 急性骨髄性白血病細胞株 / アンチセンス核酸 / レチノイン酸 / 細胞分化 / ホメオボックスB遺伝子 / ヒト化抗CD33抗体 / ATRA耐性 / 亜砒酸 / タミバロテン / CMA676 / ADF / 微少残存腫瘍(MRD) / キメラ抗体 / ミサイル療法 / モノクローナル抗体 / 癌組織血管内皮細胞 / Surrogateマーカー / 新規分子標的 / 分化誘導療法 / GVHD予防 / RI標識抗体結合物 / サロゲイトマーカー / チオレドキシン / ヒト化抗体 / 糖鎖抗原GM2,GD2 / 癌組織血管 / 分子誘導療法 / 抗体療法 / 分子標的 / アポトーシス / 耐性克服 / DNAトポイソメラーゼ / ABCカッセトファミリー / p-糖蛋白 / 抗がん剤 / mutation / 抗体サブクラス / B細胞分化 / CDR-III / B細胞レパトアー / 加齢 / 免疫グロブリン重鎖(IgH)遺伝子 / 治療効果 / PCR / 急性リンパ性白血病 / 超可変部遺伝子 / 免疫グログリン / 遺伝子マーカー / 微量残存腫瘍 / 耐性克服剤 / MDR1遺伝子 / Pー糖蛋白質 / 5ーフルオロウラシル耐性 / エトポシド耐性 / 制癌剤耐性 Less
  • Research Projects

    (22 results)
  • Co-Researchers

    (57 People)
  •  白血病における分子標的療法の至適臨床応用と併用による効果増強に関する研究

    • Principal Investigator
      OHNISHI Kazunori
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Hamamatsu University School of Medicine
  •  Study of Resistance Mechanisms of All-trans Retinoic Acid in Acute Promyelocytic Leukemia

    • Principal Investigator
      TAKESHITA Akihiro
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Hamamatsu University School of Medicine
  •  分子標的治療の臨床応用へのアプローチ

    • Principal Investigator
      上田 龍三
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Nagoya City University
  •  がん細胞分化機構の分子生物学的解明と分化誘導療法の臨床応用に関する基礎的研究Principal Investigator

    • Principal Investigator
      大野 竜三
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hamamatsu University School of Medicine
  •  Collaborative study for the best treatment of acute leukemia.Principal Investigator

    • Principal Investigator
      OHNO Ryuzo
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Hematology
    • Research Institution
      Hamamatsu University School of Medicine
  •  がん細胞分化機構の分子生物学的解明と分化誘導療法の臨床応用に関する基礎的研究Principal Investigator

    • Principal Investigator
      大野 竜三
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hamamatsu University School of Medicine
  •  臨床応用可能な抗がん剤耐性マーカーの探索とその克服

    • Principal Investigator
      桑野 信彦
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University
  •  Cytokine receptor expression and gene in myelodysplastic syndromes.Principal Investigator

    • Principal Investigator
      OHNO Ryuzo
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Hamamatsu University School of Medicine
  •  Homeobox B genes expression in human leukemia cell lines during myelomonocytic differentiation

    • Principal Investigator
      OHNISHI Kazunori
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Hamamatsu University School of Medicine
  •  がん細胞分化機構の分子生物学的の解明と分化誘導療法の臨床応用に関する基礎的研究Principal Investigator

    • Principal Investigator
      大野 竜三
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hamamatsu University School of Medicine
  •  レチノイン酸による急性前骨髄球性白血病の分化誘導療法と分化機構の細胞生物学的解明Principal Investigator

    • Principal Investigator
      大野 竜三
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hamamatsu University School of Medicine
  •  加齢にともなうB細胞免疫グロブリン遺伝子レパトアーの変遷

    • Principal Investigator
      直江 知樹
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      老化(加齢)
    • Research Institution
      Nagoya University
  •  Differentiation therapy of acute promylocytic leukemia.Principal Investigator

    • Principal Investigator
      OHNO Ryuzo, 大野 龍三
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Hamamatsu Univ.
  •  新しい制がん剤耐性遺伝子群の解析と克服法の確立

    • Principal Investigator
      桑野 信彦
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      大分医科大学
  •  遺伝子マーカーを指標にした微量残存腫瘍の高感度検出と治療効果の新評価法

    • Principal Investigator
      直江 知樹
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Nagoya University
  •  レチノイン酸による白血病の分化誘導療法と分化機構の分子生物学的解明Principal Investigator

    • Principal Investigator
      大野 竜三
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Nagoya University
  •  免疫遺伝子超可変部をマ-カとした2ステップPCR法による微量残存腫瘍の検出Principal Investigator

    • Principal Investigator
      大野 竜三
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Nagoya University
  •  Investigation on a cooperative development of stratergy on curative treatment of leukemia with Federal Republic of GermanyPrincipal Investigator

    • Principal Investigator
      OHNO Ryuzo, 大野 龍三
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Nagoya University
  •  ヌードマウス可移植性多剤耐性ヒト腫瘍細胞株を用いた抗腫瘍薬剤耐性克服に関する研究Principal Investigator

    • Principal Investigator
      大野 竜三
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Nagoya University
  •  Transfection of Multidrug Resistant Gene into Human Hematopoietic Stem Cells and its Clinical Application in Bone Marrow TransplantationPrincipal Investigator

    • Principal Investigator
      OHNO Ryuzo
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Nagoya University
  •  Analysis of genes involved in proliferation and differentiation of megakaryopoiesis using a human megakaryoblastic leukemia cell linePrincipal Investigator

    • Principal Investigator
      OHNO Ryuzo
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Nagoya University School of Medicine
  •  Differentiation of a human megaryoblastic cell line (MEG-01) and its production of platelets and platelet-derived factorsPrincipal Investigator

    • Principal Investigator
      OHNO Ryuzo
    • Project Period (FY)
      1985 – 1986
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Nagoya University
  • 1.  NAOE Tomoki (50217634)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 0 results
  • 2.  TAKESHITA Akihiro (00242769)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 3.  OHNISHI Kazunori (80252170)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 4.  福谷 久
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 5.  久保 和明
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 6.  本間 良夫 (70142114)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  武藤 泰敏 (20010069)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  橋本 祐一 (90164798)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  TANIMOTO Mitsune
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 10.  TOMONAGA Masao (40100854)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  SAITO Hidehiko (20153819)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  OGURA Michinori (40231229)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  MORISHIMA Yasuo (20220056)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  桑野 信彦 (80037431)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  石田 良司 (50150214)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 16.  垣塚 彰 (80204329)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 17.  TOBITA Tadasu
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 18.  REES John K
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 19.  FUJIMOTO Takeo (10037442)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  鬼頭 純三 (60022802)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  黒沢 良和 (10109259)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  西條 長宏 (00215526)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  前原 喜彦 (80165662)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  稲葉 実 (60085636)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  加藤 芳郎 (20152754)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  富田 章弘 (40251483)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  谷川原 祐介 (30179832)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  秋山 伸一 (60117413)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  梅沢 一夫 (70114402)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  上田 龍三 (20142169)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  真弓 忠範 (00098485)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  遠藤 啓吾 (10115800)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  山口 俊晴 (90111327)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  吉田 均 (30303548)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  王 伯銘 (60223707)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  栗山 一孝 (90128174)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  RIEHM Hansjog
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 38.  BUCHNER Thomas
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 39.  SHOU Dong
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 40.  CHEN Sai-juan
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 41.  CHEN Zhu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 42.  WANG Zen-yi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 43.  YANAGI Mitsuaki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 44.  DEGOS Laurent
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 45.  BURNETT Alan
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 46.  HOROWITZ Mary
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 47.  竹尾 高明
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 48.  伊藤 良則
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 49.  花井 陳雄
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 50.  森下 剛久
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 51.  RIEM Hansjog
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 52.  BUCHUER Thom
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 53.  CHUO Dong
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 54.  TAKESHITA Kaori
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 55.  新庄 香
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 56.  奥村 雅男
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 57.  OKUMURA Masao
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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