SAKURAI Takashi 櫻井隆

… Alternative Names

櫻井隆サクライタカシ

桜井隆サクライタカシ

桜井正樹サクライマサキ

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Researcher Number	70225845
Other IDs
External Links
Affiliation (Current)	2024: 順天堂大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 順天堂大学, 医学部, 教授 2006 – 2019: 順天堂大学, 医学部, 教授 2004 – 2005: 独立行政法人理化学研究所, 構造神経病理研究チーム, 研究員 1998: 東大, 医学(系)研究科, 助手 1997: 東京大学, 大学院・医学系研究科, 助手 … More 1994 – 1996: 東京大学, 医学部, 助手 1994 – 1995: 東京大学, 医学部(医), 助手 1992: 東京大学, 医学部(医), 助手 1990: 東京大学, 医学部, 教務職員 Less
Review Section/Research Field	Principal Investigator General pharmacology / Nerve anatomy/Neuropathology / General pharmacology / Basic Section 51030:Pathophysiologic neuroscience-related / Nerve anatomy/Neuropathology / Nerve anatomy/Neuropathology / Biological Sciences / 応用薬理学・医療系薬学 Except Principal Investigator Neuroscience in general / Biological Sciences / Neurology
Keywords	Principal Investigator アルツハイマー病 / 組換え抗体 / プロテオーム / 神経科学 / 脳神経疾患 / 脂質 / 痴呆 / アクチン / オートファジー / 小胞輸送障害 … More / βアミロイド / Alzheimer's disease / 膜ラフト / アミロイド / 薬理学 / 認知症 / 平滑筋 / カルシウムイオン / カルシウム / cDNAディスプレイ / microdomains / amvloid / 膜マイクロドメイン / lipid rafts / amyloid / 神経変性疾患 / マラカイトグリーン / レーザー / 分化 / E box / クロム親和細胞 / PC12 / アドセバリン / 神経伝達物質 / ゲルゾリン / リン脂質 / アクチンフィラメント / 細胞骨格 / 開口分泌 … More Except Principal Investigator Chromogranin A / Membrane fusion / Intracellular Na^+ concentration / G protein / Receptor / Protein kinase C / Ion permeability of cell membrane / Cytosolic Ca^<2+> Concentration / Chromaffin cell / 開口放出 / シナプトタグミンン / アクチンフィラメント / ATP / 未分化クロム親和細胞 / クロモグラニンA / 膜融合 / 細胞内ナトリウムイオン濃度 / G蛋白系 / 受容体 / プロテインキナーゼC / 細胞膜イオン透過性 / 細胞質カルシウムイオン濃度 / クロム親和細胞 / 神経科学 / 脳・神経 / 脳神経疾患 / 興奮収縮連関 / 蛍光カルシウム指示薬 / 画像解析 / リアノジン受容体 / カルシウム / 心筋 / 骨格筋 / cDNAクローニング / アドセバリン / アクチン / 神経伝達物質 / メキシレチン / 筋緊張症 / カルシウムチャネル / 海馬長期増強 / 多発性硬化症 / 脱髄 / リドカイン / ナトリウムチャネル Less

時空間制御・解析可能な変性神経突起再現モデルを用いたAβ-タウ病態関連機序の解明Principal Investigator
- Principal Investigator
  
  櫻井隆
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Juntendo University
in vitro変性神経突起モデルを用いたアルツハイマー病病態進展機序の解明Principal Investigator
- Principal Investigator
  
  櫻井隆
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Juntendo University
Early Alzheimer-like pathogenic events in endocytic membrane traffic in Down Syndrome iPSC-derived neuronsPrincipal Investigator
- Principal Investigator
  
  Sakurai Takashi
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Juntendo University
Use of FALI with cDNA display single-domain antibodies for efficient functional screening of therapeutic targetsPrincipal Investigator
- Principal Investigator
  
  SAKURAI Takashi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Juntendo University
Application of FALI with antibody-like scaffolds to the high-throughput functional proteomic screen for therapeutic targetsPrincipal Investigator
- Principal Investigator
  
  SAKURAI Takashi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Juntendo University
Microdomain-dependent acceleration mechanisms for amyloidogenic processing of amyloid precursor protein induced by endocytic membrane traffic impairmentPrincipal Investigator
- Principal Investigator
  
  SAKURAI Takashi
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Juntendo University
Application of a cell-free protein display technology to the high-throughput functional proteomic screen for regulators of neuron-glia interactionPrincipal Investigator
- Principal Investigator
  
  SAKURAI Takashi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Juntendo University
Understanding the neuronal dysfunction/neurocircuit pathology based on iPSC technology
- Principal Investigator
  
  INOUE Haruhisa
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
新規ミクロドメイン解析法を用いたアミロイド産生ー輸送連関機構の解明Principal Investigator
- Principal Investigator
  
  櫻井隆
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Juntendo University
A novel microdomain-dependent regulatory mechanism of amyloid precursor protein processingPrincipal Investigator
- Principal Investigator
  
  SAKURAI Takashi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Juntendo University
光によるリアルタイム蛋白質不活化法を用いた神経-グリア相互作用新規解析法の開発Principal Investigator
- Principal Investigator
  
  櫻井隆
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Juntendo University
Study on cholesterol-dependent regulatory mechanisms of amyloid precursor protein processing in membrane microdomainsPrincipal Investigator
- Principal Investigator
  
  SAKURAI Takashi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Juntendo University
Study on cholesterol-dependent regulatory mechanisms of amyloid precursor protein processing in lipid microdomainsPrincipal Investigator
- Principal Investigator
  
  SAKURAI Takashi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  RIKEN
細胞内シグナル伝達研究におけるレーザー分子機能不活化法の薬理学的応用Principal Investigator
- Principal Investigator
  
  桜井隆 (櫻井隆)
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General pharmacology
- Research Institution
  The University of Tokyo
興奮収縮連関機構の構造機能協関
- Principal Investigator
  
  飯野正光
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
平滑筋薬理学のin vitro系確立を目的とした平滑筋細胞分化調節遺伝子の検索Principal Investigator
- Principal Investigator
  
  櫻井隆
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General pharmacology
- Research Institution
  The University of Tokyo
平滑筋薬理学のin vitro系確立を目的とした平滑筋細胞分化調節遺伝子の検索Principal Investigator
- Principal Investigator
  
  櫻井隆
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General pharmacology
- Research Institution
  The University of Tokyo
Chromaffin cells as a neuron model
- Principal Investigator
  
  KANNO Tomio
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neuroscience in general
- Research Institution
  HOKKAIDO UNIVERSITY
神経伝達物質放出の制御における細胞骨格及びその調節系の関与Principal Investigator
- Principal Investigator
  
  櫻井隆
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
開口分泌に伴う細胞骨格構造変化のCa^<2+>・リン脂質による制御機構Principal Investigator
- Principal Investigator
  
  櫻井隆, 桜井隆
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  The University of Tokyo
神経伝達物質放出の制御における細胞骨核及びその調節系の関与
- Principal Investigator
  
  中村清二
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
神経・疾患・筋疫患の病態におけるカチオンチャネルの役割
- Principal Investigator
  
  清水輝夫, 萬年徹
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  The University of Tokyo

[Book] Experimental Models of Parkinson’s Disease. Methods in Molecular Biology, vol 23222021
- Author(s)
  Kamikubo Y, Wakisaka K, Imai Y, Sakurai T
- Total Pages
  7
- Publisher
  Humana, New York, NY.
- ISBN
  9781071614945
- Data Source
  KAKENHI-PROJECT-21H02815
[Book] 分子から迫る神経薬理学　神経薬理学連載企画（平成25年4月号～平成26年3月号）2013
- Author(s)
  櫻井隆
- Total Pages
  24
- Publisher
  中外医学社
- Data Source
  KAKENHI-PLANNED-22110007
[Journal Article] Nuclear SphK2/S1P signaling is a key regulator of ApoE production and Aβ uptake in astrocytes2024
- Author(s)
  Komai Masato、Noda Yuka、Ikeda Atsuya、Kaneshiro Nanaka、Kamikubo Yuji、Sakurai Takashi、Uehara Takashi、Takasugi Nobumasa
- Journal Title
  
  Journal of Lipid Research
  
  Volume: 65 Issue: 3 Pages: 100510-100510
- DOI
  10.1016/j.jlr.2024.100510
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06170, KAKENHI-PROJECT-20K07765, KAKENHI-PROJECT-23KJ1603, KAKENHI-PROJECT-21H02815
[Journal Article] Ex vivo analysis platforms for monitoring amyloid precursor protein cleavage2023
- Author(s)
  Kamikubo Yuji、Jin Hao、Zhou Yiyao、Niisato Kazue、Hashimoto Yoshie、Takasugi Nobumasa、Sakurai Takashi
- Journal Title
  
  Frontiers in Molecular Neuroscience
  
  Volume: 15 Pages: 1068990-1068990
- DOI
  10.3389/fnmol.2022.1068990
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02815, KAKENHI-PROJECT-20K07014, KAKENHI-PROJECT-23K06170, KAKENHI-PROJECT-20K07765
[Journal Article] Specific AAV2/PHP.eB-mediated gene transduction of CA2 pyramidal cells via injection into the lateral ventricle2023
- Author(s)
  Okamoto Kazuki、Kamikubo Yuji、Yamauchi Kenta、Okamoto Shinichiro、Takahashi Megumu、Ishida Yoko、Koike Masato、Ikegaya Yuji、Sakurai Takashi、Hioki Hiroyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 323-323
- DOI
  10.1038/s41598-022-27372-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15230, KAKENHI-PROJECT-21H02815, KAKENHI-PROJECT-22KJ1876, KAKENHI-PROJECT-20K07231, KAKENHI-PROJECT-23K21351, KAKENHI-PROJECT-20K07765
[Journal Article] Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer’s disease2022
- Author(s)
  Kaneshiro Nanaka、Komai Masato、Imaoka Ryosuke、Ikeda Atsuya、Kamikubo Yuji、Saito Takashi、Saido Takaomi C.、Tomita Taisuke、Hashimoto Tadafumi、Iwatsubo Takeshi、Sakurai Takashi、Uehara Takashi、Takasugi Nobumasa
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 3 Pages: 103869-103869
- DOI
  10.1016/j.isci.2022.103869
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-21H02815, KAKENHI-PROJECT-19J22442, KAKENHI-PROJECT-20K07014, KAKENHI-PROJECT-20K07765, KAKENHI-PROJECT-21K07270
[Journal Article] G Protein-Coupled Glutamate and GABA Receptors Form Complexes and Mutually Modulate Their Signals2020
- Author(s)
  Sakairi Hakushun、Kamikubo Yuji、Abe Masayoshi、Ikeda Keisuke、Ichiki Arata、Tabata Toshihide、Kano Masanobu、Sakurai Takashi
- Journal Title
  
  ACS Chemical Neuroscience
  
  Volume: 11 Issue: 4 Pages: 567-578
- DOI
  10.1021/acschemneuro.9b00599
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09040, KAKENHI-PROJECT-18K06461, KAKENHI-PUBLICLY-19H05204, KAKENHI-PUBLICLY-19H05415, KAKENHI-PROJECT-18H04012, KAKENHI-PROJECT-16H04667
[Journal Article] Insights into channel modulation mechanism of RYR1 mutants using Ca2+ imaging and molecular dynamics2020
- Author(s)
  Yamazawa Toshiko、Ogawa Haruo、Murayama Takashi、Yamaguchi Maki、Oyamada Hideto、Suzuki Junji、Kurebayashi Nagomi、Kanemaru Kazunori、Oguchi Katsuji、Sakurai Takashi、Iino Masamitsu
- Journal Title
  
  The Journal of General Physiology
  
  Volume: 152 Issue: 1 Pages: 0-0
- DOI
  10.1085/jgp.201812235
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-19K07306, KAKENHI-PROJECT-19K09383, KAKENHI-PROJECT-16H04667, KAKENHI-PROJECT-16K08507, KAKENHI-PROJECT-19H03198, KAKENHI-PROJECT-19H03404
[Journal Article] Structural development of a type-1 ryanodine receptor (RyR1) Ca2+-release channel inhibitor guided by endoplasmic reticulum Ca2+ assay2019
- Author(s)
  Mori Shuichi、Iinuma Hiroto、Manaka Noriaki、Ishigami-Yuasa Mari、Murayama Takashi、Nishijima Yoshiaki、Sakurai Akiko、Arai Ryota、Kurebayashi Nagomi、Sakurai Takashi、Kagechika Hiroyuki
- Journal Title
  
  European Journal of Medicinal Chemistry
  
  Volume: 179 Pages: 837-848
- DOI
  10.1016/j.ejmech.2019.06.076
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-16H04667, KAKENHI-PROJECT-16K08507, KAKENHI-PROJECT-19H03404
[Journal Article] A novel strategy for treatment of cancer cachexia targeting xanthine oxidase in the brain2019
- Author(s)
  Uzu Miaki、Nonaka Miki、Miyano Kanako、Sato Hiromi、Kurebayashi Nagomi、Yanagihara Kazuyoshi、Sakurai Takashi、Hisaka Akihiro、Uezono Yasuhito
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 140 Issue: 1 Pages: 109-112
- DOI
  10.1016/j.jphs.2019.04.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07404, KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-16H04667, KAKENHI-PROJECT-18K15037
[Journal Article] Cerebellar Neurodegeneration and Neuronal Circuit Remodeling in Golgi pH Regulator-Deficient Mice2019
- Author(s)
  Sou Yu-shin、Kakuta Soichiro、Kamikubo Yuji、Niisato Kazue、Sakurai Takashi、Parajuli Laxmi Kumar、Tanida Isei、Saito Hiromitsu、Suzuki Noboru、Sakimura Kenji、Maeda Yusuke、Kinoshita Taroh、Uchiyama Yasuo、Koike Masato
- Journal Title
  
  eNeuro
  
  Volume: 6 Issue: 3 Pages: 0427-18
- DOI
  10.1523/eneuro.0427-18.2019
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09040, KAKENHI-PROJECT-19K07276, KAKENHI-PROJECT-18K14842, KAKENHI-PROJECT-16H04667, KAKENHI-PROJECT-18H02540, KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-17K15550, KAKENHI-PLANNED-17H06422
[Journal Article] Functional analysis of juxta- and intra-membrane domains of murine APP by genome editing in Neuro2a cells2018
- Author(s)
  Kaneshiro Nanaka、Imaoka Ryosuke、Komai Masato、Kashiyama Taku、Sakurai Takashi、Uehara Takashi、Takasugi Nobumasa
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 501 Issue: 4 Pages: 1023-1028
- DOI
  10.1016/j.bbrc.2018.05.102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08272, KAKENHI-PROJECT-16H04667
[Journal Article] Efficient high-throughput screening by ER Ca2+measurement to identify inhibitors of ryanodine receptor Ca2+-release channels2018
- Author(s)
  Murayama Takashi、Kurebayashi Nagomi、Ikegami-Yuasa Mari、Mori Shuichi、Suzuki Yukina、Akima Ryunosuke、Ogawa Haruo、Suzuki Junji、Kanemaru Kazunori、Oyamada Hideto、Kiuchi Yuji、Iino Masamitsu、Kagechika Hiroyuki、Sakurai Takashi
- Journal Title
  
  Molecular Pharmacology
  
  Volume: - Issue: 1 Pages: 722-730
- DOI
  10.1124/mol.117.111468
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08243, KAKENHI-PLANNED-25117002, KAKENHI-PROJECT-16K08507, KAKENHI-PROJECT-18K06572, KAKENHI-PROJECT-16H04667, KAKENHI-PROJECT-25221304
[Journal Article] TMEM30A is a candidate interacting partner for the β-carboxyl-terminal fragment of amyloid-β precursor protein in endosomes2018
- Author(s)
  Takasugi Nobumasa、Araya Runa、Kamikubo Yuji、Kaneshiro Nanaka、Imaoka Ryosuke、Jin Hao、Kashiyama Taku、Hashimoto Yoshie、Kurosawa Masaru、Uehara Takashi、Nukina Nobuyuki、Sakurai Takashi
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 8 Pages: 0200988-0200988
- DOI
  10.1371/journal.pone.0200988
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08272, KAKENHI-PROJECT-17K09040, KAKENHI-PROJECT-17H01564, KAKENHI-PROJECT-16H04667, KAKENHI-PROJECT-18H00446
[Journal Article] Induction of Oxidative Stress and Cell Death in Neural Cells by Silica Nanoparticles2018
- Author(s)
  Kamikubo Yuji、Yamana Tomohito、Hashimoto Yoshie、Sakurai Takashi
- Journal Title
  
  ACS Chemical Neuroscience
  
  Volume: 10 Issue: 1 Pages: 304-312
- DOI
  10.1021/acschemneuro.8b00248
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09040, KAKENHI-PROJECT-16H04667
[Journal Article] Consecutive Analysis of BACE1 Function on Developing and Developed Neuronal Cells2017
- Author(s)
  Kamikubo Y, Takasugi N, Niisato K, Hashimoto Y, Sakurai T
- Journal Title
  
  J Alzheimers Diｓ
  
  Volume: 56 Issue: 2 Pages: 641-653
- DOI
  10.3233/jad-160806
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H04667, KAKENHI-PROJECT-26430059, KAKENHI-PROJECT-26460707, KAKENHI-PROJECT-17K09040
[Journal Article] Application of surface plasmon　resonance imaging to monitoring G protein-coupled receptor signaling and its modulation in a heterologous expression system2016
- Author(s)
  Yuki Nonobe, Tomoki Yokoyama, Yuji Kamikubo, Sho Yoshida, Nozomi Hisajima, Hiroaki Shinohara, Yuki Shiraishi, Takashi Sakurai and Toshihide Tabata
- Journal Title
  
  BMC Biotechnology
  
  Volume: 16：36 Issue: 1 Pages: 1-9
- DOI
  10.1186/s12896-016-0266-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26630424, KAKENHI-PROJECT-16H04667, KAKENHI-PROJECT-26460707, KAKENHI-PROJECT-26430012
[Journal Article] Depletion of p62 reduces nuclear inclusions and paradoxically ameliorates disease phenotypes in Huntington's model mice.2015
- Author(s)
  4)Kurosawa M, Matsumoto G, Kino Y, Okuno M, Kurosawa-Yamada M, Washizu C, Taniguchi H, Nakaso K, Yanagawa T, Warabi E, Shimogori T, Sakurai T, Hattori N, Nukina N.
- Journal Title
  
  Hum Mol Genet.
  
  Volume: 24 Issue: 4 Pages: 1092-105
- DOI
  10.1093/hmg/ddu522
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-22110004, KAKENHI-PLANNED-22110007, KAKENHI-PROJECT-23300128, KAKENHI-PROJECT-23500434, KAKENHI-PROJECT-25220103
[Journal Article] Sequence of molecular events during maturation of developing mouse prefrontal cortex.2015
- Author(s)
  Ueda S, Niwa M, Hioki H, Sohn J, Kaneko T, Sawa A, Sakurai T.
- Journal Title
  
  Mol Neuropsychiatry
  
  Volume: In Press
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22110007
[Journal Article] Mg2+- and ATP-dependent inhibition of TRPM7 by oxidative stress.2014
- Author(s)
  Inoue H, Murayama T, Tashiro M, Sakurai T, Konishi M.
- Journal Title
  
  Free Radic Biol Med,
  
  Volume: 72 Pages: 257-266
- DOI
  10.1016/j.freeradbiomed.2014.04.015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22110007, KAKENHI-PROJECT-24590330, KAKENHI-PROJECT-25460302
[Journal Article] Assembly of the cochlear gap junction macromolecular complex requires connexin 26.2014
- Author(s)
  Kamiya K, Yum SW, Kurebayashi N, Muraki M, Ogawa K, Karasawa K, Miwa A, Guo X, Gotoh S, Sugitani Y, Yamanaka H, Ito-Kawashima S, Iizuka T, Sakurai T, Noda T, Minowa O, Ikeda K.
- Journal Title
  
  J Clin Invest,
  
  Volume: 124 Issue: 4 Pages: 1598-1607
- DOI
  10.1172/jci67621
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22110007, KAKENHI-PROJECT-24501325, KAKENHI-PROJECT-24590331, KAKENHI-PUBLICLY-25136718, KAKENHI-PROJECT-25293351, KAKENHI-PROJECT-25462653, KAKENHI-PROJECT-25670721, KAKENHI-PROJECT-221S0001
[Journal Article] 分子から迫る神経薬理学2014
- Author(s)
  櫻井隆
- Journal Title
  
  Clinical Neuroscience 神経薬理学連載企画（2013～）
  
  Volume: 32（4）-33（3）
- Data Source
  KAKENHI-PLANNED-22110007
[Journal Article] 受容体の情報伝達を分子構造・局在の視点から理解する2013
- Author(s)
  櫻井隆
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 31 Pages: 8-9
- Data Source
  KAKENHI-PROJECT-23300128
[Journal Article] Design and synthesis of cyclic ADP-4-thioribose as a stable equivalent of cyclic ADP-ribose, a calcium ion-mobilizing second messenger.2013
- Author(s)
  Tsuzuki, T., Sakaguchi, N., Kudoh, T., Takano, S., Uehara, M., Murayama, T., Sakurai, T., Hashii, M., Higashida, H., Weber, K., Guse, A.H., Kameda, T., Hirokawa, T., Kumaki, Y., Potter, B.V., Fukuda, H., Arisawa, M., Shuto, S.
- Journal Title
  
  Angew. Chem. Int. Ed. Engl
  
  Volume: 52 Issue: 26 Pages: 6633-6637
- DOI
  10.1002/anie.201302098
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22110007, KAKENHI-PROJECT-23246013, KAKENHI-PUBLICLY-25105702, KAKENHI-PROJECT-25670049
[Journal Article] Functional cooperation of metabotropic adenosine and glutamate receptors regulates postsynaptic plasticity in the cerebellum.2013
- Author(s)
  Kamikubo, Y., Shimomura, T., Fujita, Y., Tabata, T., Kashiyama, T., Sakurai, T., Fukurotani, K., Kano, M.
- Journal Title
  
  J. Neurosci
  
  Volume: 33 Issue: 47 Pages: 18661-18671
- DOI
  10.1523/jneurosci.5567-12.2013
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22110007, KAKENHI-PROJECT-23300128, KAKENHI-PROJECT-23500384, KAKENHI-PROJECT-25000015
[Journal Article] マイクロドメインスイッチング:アミロイド前駆体蛋白質のマイクロドメイン依存性代謝調節とシンタキシンI2010
- Author(s)
  櫻井隆
- Journal Title
  
  生体の科学
  
  Volume: 61 Pages: 252-256
- Data Source
  KAKENHI-PROJECT-20300125
[Journal Article] マイクロドメインスイッチング:アミロイド前駆体蛋白質のマイクロドメイン依存性代謝調節とシンタキシンI2010
- Author(s)
  櫻井隆
- Journal Title
  
  生体の科学
  
  Volume: 61 Pages: 252-256
- Data Source
  KAKENHI-PUBLICLY-21113525
[Journal Article] マイクロドメインスイッチング:アミロイド前駆体蛋白質のマイクロドメイン依存性代謝調節とシンタキシンI.2010
- Author(s)
  櫻井隆、樫山拓、貫名信行
- Journal Title
  
  生体の科学 61
  
  Pages: 252-256
- Data Source
  KAKENHI-PROJECT-20300125
[Journal Article] Mutant SOD1 impairs axonal transport of choline acetyltransferase and acetylcholine release by sequestering KAP32009
- Author(s)
  Tateno M, Kato S, Sakurai T, Nukina N, Takahashi R, Araki T
- Journal Title
  
  Hum Mol Genet 18
  
  Pages: 942-955
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300125
[Journal Article] βセクレターゼの構造と活性調節2008
- Author(s)
  櫻井隆
- Journal Title
  
  日本臨林増刊号「アルツハイマー病-基礎研究から予防、治療の新しいパラダイム-」 66(Suppl 1)
  
  Pages: 52-55
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500283
[Journal Article] Membrane microdomain switching : a regulatory mechanism of amyloid precursor protein processing.2008
- Author(s)
  Sakurai, Takashi
- Journal Title
  
  J Cell Biol 183
  
  Pages: 339-352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300125
[Journal Article] Membrane microdomain switching : a regulatory mechanism of amyloid precursor protein processing2008
- Author(s)
  Sakurai T, Kaneko K, Okuno M, Wada K, 樫山拓, Shimizu H, Akagi T, Hashikawa T, Nukina N
- Journal Title
  
  J Cell Biol 183
  
  Pages: 339-352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300125
[Journal Article] βセクレターゼの構造と活性調節2008
- Author(s)
  櫻井隆
- Journal Title
  
  日本臨牀増刊号「アルツハイマー病-基礎研究から予防・治療の新しいパラダイム-」 66(Suppl 1)
  
  Pages: 52-55
- Data Source
  KAKENHI-PROJECT-18500283
[Journal Article] Crystal structure of an active form of BACE1 : an enzyme responsible for amyloid beta protein production2008
- Author(s)
  Shimizu H, Tosaki A, Kaneko K, Hisano T, Sakurai T, Nukina N
- Journal Title
  
  Mol Cell Biol 28
  
  Pages: 3663-3671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300125
[Journal Article] β切断の機能と調節機構2007
- Author(s)
  櫻井隆
- Journal Title
  
  実験医学増刊脳神経疾患の分子病態と治療への展開 25
  
  Pages: 1923-1927
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500283
[Journal Article] ApoEとコレステロール,膜ラフト2006
- Author(s)
  櫻井隆
- Journal Title
  
  最新医学 61
  
  Pages: 2405-2410
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500283
[Journal Article] ApoEとコレステロール・膜ラフト2006
- Author(s)
  櫻井隆
- Journal Title
  
  最新医学 61
  
  Pages: 2405-2410
- Data Source
  KAKENHI-PROJECT-18500283
[Patent] アルツハイマー病予防治療薬のスクリーニング法2014
- Inventor(s)
  高杉展正、櫻井隆、清水瑠奈
- Industrial Property Rights Holder
  学校法人順天堂
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-132309
- Filing Date
  2014-06-27
- Data Source
  KAKENHI-PLANNED-22110007
[Patent] 特許権2014
- Inventor(s)
  高杉展正、新家瑠奈、櫻井隆
- Industrial Property Rights Holder
  学校法人順天堂
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-132309
- Filing Date
  2014-06-27
- Data Source
  KAKENHI-PROJECT-23300128
[Presentation] 脳器官培養法を用いたアミロイドβ分泌とアミロイド斑形成の経時的解析2023
- Author(s)
  上窪裕二, 周藝瑶, 櫻井隆
- Organizer
  第53回日本神経精神薬理学会年会
- Data Source
  KAKENHI-PROJECT-21H02815
[Presentation] 脳スライス培養を用いたアミロイドプラーク形成と神経突起変性の解析2023
- Author(s)
  周藝瑶、上窪裕二、石田葉子、日置寛之、櫻井隆
- Organizer
  第147回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-21H02815
[Presentation] 脳組織内部における１分子イメージング2023
- Author(s)
  大久保洋平, 並木繁行, 浅沼大祐, 櫻井隆, 廣瀬謙造
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21H02815
[Presentation] Phospholipid flippases ATP8A1 and ATP8A2 regulate the functional expression of synaptic proteins in hippocampal neurons2023
- Author(s)
  Kawase M, Matsuda T, Umemura Y, Oishi H, Sakurai T, Hattori M
- Organizer
  Neuroscience 2023, Washington DC, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02815
[Presentation] 代謝型グルタミン酸受容体とGABAB受容体における異種GPCR間相互作用2023
- Author(s)
  坂入伯駿、上窪裕二、櫻井隆
- Organizer
  第147回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-21H02815
[Presentation] 海馬スライス培養を用いたアミロイドプラーク形成と神経突起変性の経時的解析2023
- Author(s)
  周藝瑶, 上窪裕二, 石田葉子, 日置寛之, 櫻井隆
- Organizer
  第46回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-21H02815
[Presentation] 成体脳におけるセマフォリン3A発現を定量するELISAシステムの確立2023
- Author(s)
  杉山黎、林克儀、中村史雄、櫻井隆、五嶋良郎、山下直也
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21H02815
[Presentation] 1型代謝型グルタミン酸受容体とGABAB受容体における異種GPCR間複合体形成と双方向シグナル調節2022
- Author(s)
  坂入伯駿、上窪裕二、田端俊英、櫻井隆
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21H02815
[Presentation] 脳組織内部におけるシナプス分子動態の１分子イメージング2022
- Author(s)
  大久保洋平, 並木繁行, 浅沼大祐, 櫻井隆, 廣瀬謙造
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21H02815
[Presentation] Semaphorin3A-PlexinAシグナルがアミロイドβ前駆タンパク質の機能や代謝に与える影響2022
- Author(s)
  関口拓己, 櫻井隆, 山下直也
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21H02815
[Presentation] Semaphorin3A-PlexinA シグナルによるアミロイドβ前駆タンパク質の機能及び代謝制御2022
- Author(s)
  関口拓己、櫻井隆、山下直也
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21H02815
[Presentation] 成体脳におけるセマフォリン3A発現を定量するELISAシステムの確立2022
- Author(s)
  山下直也、水谷由衣、實木-高橋葵、林克儀、中村史雄、櫻井隆、五嶋良郎
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21H02815
[Presentation] 成体脳におけるセマフォリン3A発現を定量するELISAシステムの確立2022
- Author(s)
  古川涼音, 小林瑞季, 林克儀, 中村史雄, 櫻井隆, 五嶋良郎, 山下直也
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21H02815
[Presentation] Axonal targeting of TrkA-APP complex via transcytosis2021
- Author(s)
  Yamashita N, Sakurai T
- Organizer
  第44回日本神経科学大会 / CJK第1回国際会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02815
[Presentation] Hippocampal CA2 labeling with an AAV2/PHP.eB vector2021
- Author(s)
  Okamoto K, Kamikubo Y, Yamauchi K, Okamoto S, Takahashi M, Ishida Y, Sakurai T, Koike M, Ikegaya Y, Hioki H
- Organizer
  第44回日本神経科学大会 / CJK第1回国際会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02815
[Presentation] Effects of RYR2 inhibitors on Ca2+ signals in healthy and diseased cardiac cells2020
- Author(s)
  Kurebayashi N, Murayama T, Konishi M, Mori S, Ishigami-Yuasa M, Kagechika H, Ogawa H, Morimoto S, Sakurai T
- Organizer
  64th Annual Meeting of the Biophysical Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04667
[Presentation] 新規RyR1抑制薬の悪性高熱症モデルマウスに対する効果2020
- Author(s)
  村山尚, 山澤徳志子, 小林琢也, 呉林なごみ, 野口悟, 西野一三, 森修一, 影近弘之, Lopez JR, Allen PD, 櫻井隆
- Organizer
  第93回日本薬理学会年会（誌上開催）
- Data Source
  KAKENHI-PROJECT-16H04667
[Presentation] Characterization of novel RyR1-selective inhibitors identified by high-throughput screening using ER Ca2+ measurement2020
- Author(s)
  Matsukawa H, Murayama T, Kobayashi T, Kurebayashi N, Yamazawa T, Ishigami-Yuasa M, Mori S, Kagechika H, Sakurai T
- Organizer
  64th Annual Meeting of the Biophysical Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04667
[Presentation] 1型代謝型グルタミン酸受容体とGABAB受容体の細胞膜上における複合体形成と相互機能調節2020
- Author(s)
  坂入伯駿, 上窪裕二, 田端俊英, 櫻井隆
- Organizer
  第93回日本薬理学会年会（誌上開催）
- Data Source
  KAKENHI-PROJECT-16H04667
[Presentation] ナノ粒子による酸化ストレスの誘導と神経細胞死2020
- Author(s)
  上窪裕二, 橋本祥江, 井上由理子, 坂入伯駿, 櫻井隆
- Organizer
  第93回日本薬理学会年会（誌上開催）
- Data Source
  KAKENHI-PROJECT-16H04667
[Presentation] Cytotoxicity of nanomaterials and neuronal cell death2020
- Author(s)
  上窪裕二, 橋本祥江, 櫻井隆
- Organizer
  第97回日本生理学会大会（誌上開催）
- Data Source
  KAKENHI-PROJECT-16H04667
[Presentation] Improvements of ER-Ca2+ based high-throughput screening method for searching novel RYR2 inhibitors2020
- Author(s)
  Ito M, Kurebayashi N, Murayama T, Tamura M, Suzuki J, Kanemaru K, Iino M, Sakurai T
- Organizer
  64th Annual Meeting of the Biophysical Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04667
[Presentation] ナノマテリアルによる酸化ストレスと神経細胞死2019
- Author(s)
  上窪裕二, 山名智人, 井上由理子, 橋本祥江, 櫻井隆
- Organizer
  NEURO2019
- Data Source
  KAKENHI-PROJECT-16H04667
[Presentation] シリカナノ粒子による酸化ストレスと神経細胞死2019
- Author(s)
  上窪裕二、山名智人、橋本祥江、櫻井隆
- Organizer
  第92回日本薬理学会年会（大阪）
- Data Source
  KAKENHI-PROJECT-16H04667
[Presentation] 小胞体Ca2+濃度測定による新規1型リアノジン受容体阻害剤の探索2019
- Author(s)
  松川紘之, 村山尚, 小林琢也, 呉林なごみ, 湯浅磨里, 森修一, 影近弘之, 櫻井隆
- Organizer
  第5回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-16H04667
[Presentation] 代謝型グルタミン酸受容体1型とGABAB受容体の複合体形成と機能的相互作用2019
- Author(s)
  坂入伯駿, 上窪裕二, 阿部匡良, 池田圭祐, 一木新, 田端俊英, 櫻井隆
- Organizer
  NEURO2019
- Data Source
  KAKENHI-PROJECT-16H04667
[Presentation] 悪性高熱症モデルマウスを用いた新規RyR1阻害薬の治療効果の検討2019
- Author(s)
  村山尚, 山澤徳志子, 小林琢也, 呉林なごみ, 野口悟, 井上高良, 井上由紀子, 森修一, 飯沼大翔, 間中紀暁, 湯浅磨里, 影近弘之, 西野一三, 櫻井隆
- Organizer
  第5回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-16H04667
[Presentation] トランスサイトーシスを介したTrkAシグナル複合体の軸索への局在化2019
- Author(s)
  山下直也, 櫻井隆
- Organizer
  NEURO2019
- Data Source
  KAKENHI-PROJECT-16H04667
[Presentation] 小胞体Ca2+濃度測定法を用いた新規1型リアノジン受容体阻害剤の探索2019
- Author(s)
  松川紘之, 村山尚, 小林琢也, 呉林なごみ, 湯浅磨里, 森修一, 影近弘之, 櫻井隆
- Organizer
  第141日本薬理学会関東部会（誌上開催）
- Data Source
  KAKENHI-PROJECT-16H04667
[Presentation] トランスサイトーシスを介したTrkAおよびTrkA相互作用分子の軸索への局在化2019
- Author(s)
  山下直也、櫻井隆
- Organizer
  第92回日本薬理学会年会（大阪）
- Data Source
  KAKENHI-PROJECT-16H04667
[Presentation] セクレターゼはシナプス発達と成熟を制御する2018
- Author(s)
  上窪裕二, 新里和恵坂入伯駿, 橋本祥江, 櫻井　隆
- Organizer
  第41回日本神経科学大会（神戸）
- Data Source
  KAKENHI-PROJECT-16H04667
[Presentation] 小胞体内Ca2+ 濃度測定によるリアノジン受容体阻害薬探索システムの開発2018
- Author(s)
  村山　尚, 呉林なごみ, 湯浅（石上）磨里, 森　修一, 鈴木志奈, 秋間龍之介, 小川治夫, 鈴木純二, 金丸和典, 小山田英人, 木内祐二, 飯野正光, 影近弘之, 櫻井　隆
- Organizer
  第139回日本薬理学会関東部会(東京)
- Data Source
  KAKENHI-PROJECT-16H04667
[Presentation] Continuous inhibition of secretase regulates synapse formation.2018
- Author(s)
  Kamikubo Y, Niisato K, Jingo K, Jin H, Sakurai T
- Organizer
  18th World Congress of Basic and Clinical Pharmacology (Kyoto)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04667
[Presentation] 小胞体内Ca2+ 濃度測定による新規RyR1阻害薬のハイスループットスクリーニング2018
- Author(s)
  村山　尚, 呉林なごみ, 湯浅（石上）磨里, 森　修一, 鈴木志奈, 秋間龍之介, 小川治夫, 鈴木純二, 金丸和典, 小山田英人, 木内祐二, 飯野正光, 影近弘之, 櫻井　隆
- Organizer
  日本筋学会第4回学術集会（岡山）
- Data Source
  KAKENHI-PROJECT-16H04667
[Presentation] 神経細胞におけるニューレグリン-3の切断と細胞内局在の解析2017
- Author(s)
  樫山拓、橋本祥江、櫻井隆
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2017-03-16
- Data Source
  KAKENHI-PROJECT-16H04667
[Presentation] cDNAディスプレイ法を用いた単ドメイン抗体のFALIへの応用2017
- Author(s)
  橋本祥江、望月佑樹、熊地重文、樫山拓、上窪裕二、藤本健造、根本直人、櫻井隆
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-16K15206
[Presentation] 中枢神経系に発現するGPCR間の異種複合体形成と機能的相互作用2017
- Author(s)
  坂入伯駿、上窪裕二、田端俊英、櫻井隆
- Organizer
  第137回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-16H04667
[Presentation] 海馬スライス培養を用いたβセクレターゼ活性とAPP切断産物の解析2017
- Author(s)
  金浩、上窪裕二、新里和恵、橋本祥江、櫻井隆
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2017-03-16
- Data Source
  KAKENHI-PROJECT-16H04667
[Presentation] 海馬スライス培養標本におけるセクレターゼの持続的阻害の効果2017
- Author(s)
  金浩、上窪裕二、神後宏一、橋本祥江、櫻井隆
- Organizer
  第36回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-16H04667
[Presentation] セクレターゼ阻害によるシナプス形成への影響2017
- Author(s)
  神後宏一、上窪裕二、新里和恵、橋本祥江、櫻井隆
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16H04667
[Presentation] 海馬スライス培養標本を用いたβセクレターゼの経時的解析2016
- Author(s)
  上窪裕二、金浩、新里和恵、櫻井隆
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-07-21
- Data Source
  KAKENHI-PROJECT-16H04667
[Presentation] Proteins in striated muscles that transcribed from the contiguous region of connectin gene.2015
- Author(s)
  Hanashima A, Sato N, Kimura S, Sakurai T, Murayama T.
- Organizer
  Biophysical Society 59th annual meeting. Baltimore
- Place of Presentation
  Maryland, USA
- Year and Date
  2015-02-10
- Data Source
  KAKENHI-PLANNED-22110007
[Presentation] 代謝型グルタミン酸受容体1型はアデノシンA1受容体のシグナルを制御する2015
- Author(s)
  坂入伯駿、上窪裕二、櫻井隆
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋
- Year and Date
  2015-03-18
- Data Source
  KAKENHI-PLANNED-22110007
[Presentation] Maturation processes of developing prefrontal cortex of normal and disease model mice2015
- Author(s)
  Sakurai T, Ueda S, Niwa M, Hioki H, Sohn J, Kaneko T, Sawa A.
- Organizer
  第120回日本解剖学会・第92回日本生理学会合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-03-23
- Data Source
  KAKENHI-PLANNED-22110007
[Presentation] シュードタイプバキュロウイルスを用いた疾患変異ダイニン重鎖の神経細胞への発現2015
- Author(s)
  秋元貴至、村山尚、樫山拓、上窪裕二、橋本祥江、市川宗厳、豊島陽子、櫻井隆
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋
- Year and Date
  2015-03-19
- Data Source
  KAKENHI-PLANNED-22110007
[Presentation] 横紋筋の新規コネクチン関連タンパク質の解析2015
- Author(s)
  花島章、櫻井隆、村山尚
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋
- Year and Date
  2015-03-19
- Data Source
  KAKENHI-PLANNED-22110007
[Presentation] APP-βCTFに特異的に結合するエンドソームタンパク質の解析2015
- Author(s)
  高杉展正、新家瑠奈、櫻井隆
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋
- Year and Date
  2015-03-19
- Data Source
  KAKENHI-PLANNED-22110007
[Presentation] 1型リアノジン受容体チャネルに対する中央領域疾患変異の効果2015
- Author(s)
  村山尚、呉林なごみ、山澤徳志子、小山田英人、鈴木純二、金丸和典、小口勝司、飯野正光、櫻井隆
- Organizer
  第120回日本解剖学会総会全国学術集会・第 92回日本生理学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-03-22
- Data Source
  KAKENHI-PLANNED-22110007
[Presentation] Effects of MH and CCD mutations in the central region on RyR1 channels.2015
- Author(s)
  Murayama T, Kurebayashi N, Yamazawa T, Oyamada H, Suzuki J, Kanemaru K, Oguchi K, Iino M, Sakurai T.
- Organizer
  Biophysical Society 59th annual meeting. Baltimore
- Place of Presentation
  Maryland, USA
- Year and Date
  2015-02-09
- Data Source
  KAKENHI-PLANNED-22110007
[Presentation] 1型リアノジン受容体チャネル活性に対する中央領域疾患変異の効果2015
- Author(s)
  村山尚、呉林なごみ、山澤徳志子、小山田英人、鈴木純二、金丸和典、小口勝司、飯野正光、櫻井隆
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋
- Year and Date
  2015-03-20
- Data Source
  KAKENHI-PLANNED-22110007
[Presentation] APP-βCTFに特異的に結合するエンドソームタンパク質の解析2015
- Author(s)
  高杉展正、新家瑠奈、櫻井隆
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場（愛知県・名古屋市）
- Year and Date
  2015-03-19
- Data Source
  KAKENHI-PROJECT-23300128
[Presentation] 海馬スライス培養系を用いたβセクレターゼ活性の解析2014
- Author(s)
  上窪裕二、櫻井隆
- Organizer
  第35回日本神経科学大会 (Neuroscience2012)
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2014-09-12
- Data Source
  KAKENHI-PROJECT-23300128
[Presentation] 海馬スライス培養系を用いたβセクレターゼ活性の解析2014
- Author(s)
  上窪裕二、櫻井隆
- Organizer
  第35回日本神経科学大会(Neuroscience2014)
- Place of Presentation
  横浜
- Year and Date
  2014-09-12
- Data Source
  KAKENHI-PLANNED-22110007
[Presentation] The analysis of novel proteins in striated muscle that are transcribed from connectin upstream genes.2014
- Author(s)
  Hanashima A, Kimura S, Sakurai T, Murayama T.
- Organizer
  17th World Congress of Basic and Clinical Pharmacology.
- Place of Presentation
  Capetown, South Africa
- Year and Date
  2014-07-15
- Data Source
  KAKENHI-PLANNED-22110007
[Presentation] 1型リアノジン受容体における中央領域疾患変異体の機能解析2014
- Author(s)
  村山尚、呉林なごみ、山澤徳志子、小山田英人、鈴木純二、金丸和典、小口勝司、飯野正光、櫻井隆
- Organizer
  第131回日本薬理学会関東部会
- Place of Presentation
  横浜
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PLANNED-22110007
[Presentation] アデノシンA1受容体と代謝型グルタミン酸受容体の複合体形成と機能的相互作用2014
- Author(s)
  上窪裕二、坂入伯駿、田端俊英、櫻井隆
- Organizer
  第131回日本薬理学会関東部会
- Place of Presentation
  横浜
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PLANNED-22110007
[Presentation] Gene expression profiles of developing prefrontal cortex of normal and disease model mice.2014
- Author(s)
  Ueda S, Niwa M, Hioki H, Sohn J, Kaneko T, Sawa A, Sakurai T.
- Organizer
  Axon Guidance, Synapse Formation and Regeneration 2014 (CSHL Meeting)
- Place of Presentation
  Cold Spring Harbor, NY, USA
- Year and Date
  2014-09-19
- Data Source
  KAKENHI-PLANNED-22110007
[Presentation] Gene expression profiles of developing prefrontal cortex of normal and disease model mice.2014
- Author(s)
  Ueda S, Niwa M, Hioki H, Sohn J, Kaneko T, Sawa A, Sakurai T.
- Organizer
  包括脳ネットワーク冬のワークショップ
- Place of Presentation
  東京
- Year and Date
  2014-12-12
- Data Source
  KAKENHI-PLANNED-22110007
[Presentation] iPS細胞由来神経細胞におけるシナプス機能可視化の試み2011
- Author(s)
  今村恵子, 上窪裕二, 櫻井隆, 井上治久
- Organizer
  2011年度包括脳ネットワーク夏のワークショップ
- Place of Presentation
  神戸
- Year and Date
  2011-08-22
- Data Source
  KAKENHI-PLANNED-22110007
[Presentation] 切断端抗体を用いたBACE1依存的neuregulin 1シグナル伝達機構の解析2011
- Author(s)
  樫山拓、櫻井隆
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  (年会中止のため誌上発表)
- Data Source
  KAKENHI-PROJECT-20300125
[Presentation] Detection of BACE1-mediated activation of neuregulin 1-erbB signaling using a cleavage site specific antibody2011
- Author(s)
  樫山拓, 櫻井隆
- Organizer
  Inaugural International Academy of Sportology
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20300125
[Presentation] 切断端を特異的に認識する抗体を用いたニューレグリン切断機構の解析2010
- Author(s)
  樫山拓、櫻井隆
- Organizer
  第123回日本薬理学会関東部会
- Place of Presentation
  栃木
- Data Source
  KAKENHI-PROJECT-20300125
[Presentation] Membrane microdomain switching-a regulatory mechanism of amyloid precursor protein processing2009
- Author(s)
  Sakurai T, Kashiyama T, Shimizu H, Nukina N
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸(シンポジウム)
- Data Source
  KAKENHI-PROJECT-20300125
[Presentation] マイクロドメインスイッチング:膜マイクロドメイン依存性のアミロイド前駆体蛋白質代謝制御機構2009
- Author(s)
  櫻井隆
- Organizer
  第82回日本生化学会大会シンポジウム
- Place of Presentation
  神戸
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PUBLICLY-21113525
[Presentation] マイクロドメインスイッチング:膜マイクロドメイン依存性のアミロイド前駆体蛋白質代謝制御機構2009
- Author(s)
  櫻井隆
- Organizer
  第82回日本生化学会大会シンポジウム
- Place of Presentation
  神戸
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20300125
[Presentation] Membrane microdomain switching-a regulatory mechanism of amyloid precursor protein processing-2009
- Author(s)
  櫻井隆
- Organizer
  第59回FCCAセミナー/環境医学研究所ワークショップ
- Place of Presentation
  東京
- Year and Date
  2009-10-20
- Data Source
  KAKENHI-PROJECT-20300125
[Presentation] Membrane microdomain switching-a regulatory mechanism of amyloidprecursor protein processing-2009
- Author(s)
  櫻井隆
- Organizer
  第59回FCCAセミナー/環境医学研究所ワークショップ
- Place of Presentation
  東京
- Year and Date
  2009-10-20
- Data Source
  KAKENHI-PUBLICLY-21113525
[Presentation] Membrane microdomain switching - a new regulatory mechanism of amyloid precursor protein processing2008
- Author(s)
  Sakurai, Takashi
- Organizer
  Neuroscience 2008
- Place of Presentation
  Washington, DC USA
- Year and Date
  2008-11-18
- Data Source
  KAKENHI-PROJECT-20300125
[Presentation] マイクロドメインスイッチング-膜マイクロドメイン依存性の新規アミロイド前駆体蛋白質代謝制御機構2008
- Author(s)
  櫻井隆
- Organizer
  第81回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-19
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500283
[Presentation] Membrane microdomain switching-a new regulatory mechanism of amyloid precursor protein processing2008
- Author(s)
  Sakurai T, Kaneko K, Okuno M, Wada K, Kashiyama T, Shimizu H, Nukina N
- Organizer
  Neuroscience 2008
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-20300125
[Presentation] マイクロドメインスイッチング : 膜マイクロドメイン依存性の新規アミロイド前駆体蛋白質代謝制御機構2008
- Author(s)
  櫻井隆、金子貢巳、奥野弥佐子、和田浩司、樫山拓、清水英明、貫名信行
- Organizer
  第27回日本認知症学会
- Place of Presentation
  前橋
- Data Source
  KAKENHI-PROJECT-20300125
[Presentation] A new membrane microdomain-dependent regulatory mechanism of amyloid precursor protein processing2008
- Author(s)
  Sakurai, T, et. al.
- Organizer
  The 81th Annual Meeting of The Japanese Pharmacological Society
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2008-03-19
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500283
[Presentation] 膜ミクロドメイン依存性の新規アミロイド前駆体蛋白質代謝制御機構2007
- Author(s)
  櫻井隆
- Organizer
  第30回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2007-09-11
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500283
[Presentation] Membrane microdomain switching - a new cholesterol-dependent regulatory mechanism of amyloid precursor protein processing2007
- Author(s)
  Sakurai, T, et. al.
- Organizer
  The 117th Kanto Area Regional Meeting of the Japanese Pharmacological Society
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2007-10-06
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500283
[Presentation] 膜ミクロドメイン依存性の新規アミロイド前駆体蛋白質代謝制御機構2007
- Author(s)
  櫻井隆
- Organizer
  第80回日本薬理学会年会
- Place of Presentation
  名古屋
- Year and Date
  2007-03-15
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500283
[Presentation] マイクロドメインスイッチング-コレステロール依存性のアミロイドβ産生調節機構2007
- Author(s)
  櫻井隆
- Organizer
  第117回日本薬理学会関東部会
- Place of Presentation
  東京
- Year and Date
  2007-10-06
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500283
[Presentation] Membrane microdomain switching - a new regulatory mechanism of amyloid precursor protein processing2007
- Author(s)
  Sakurai, T, et. al.
- Organizer
  The 80th Annual Meeting of The Japanese Pharmacological Society
- Place of Presentation
  Nagoya, Japan
- Year and Date
  2007-03-15
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500283
[Presentation] A new membrane microdomain-dependent regulatory mechanism of amyloid precursor protein processing2007
- Author(s)
  Sakurai, T, et. al.
- Organizer
  The 30th Annual Meeting of The Japanese Neuroscience Society
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2007-09-11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500283
[Presentation] 海馬切片培養標本を用いたβ-セクレターゼの解析
- Author(s)
  上窪裕二、櫻井隆
- Organizer
  第36回日本神経科学大会 Neuro2013
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23300128
[Presentation] 海馬スライス培養標本を用いたβ-セクレターゼ機能の評価
- Author(s)
  上窪裕二、櫻井隆
- Organizer
  第128回日本薬理学会関東部会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23300128
[Presentation] GPCR 複合体形成によるシグナル伝達制御
- Author(s)
  坂入伯駿、上窪裕二、櫻井隆
- Organizer
  第129回日本薬理学会関東部会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PLANNED-22110007
[Presentation] 海馬スライス培養標本を用いたβ-セクレターゼ機能の評価
- Author(s)
  上窪裕二、櫻井隆
- Organizer
  第128回日本薬理学会関東部会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PLANNED-22110007
[Presentation] APP-βCTFに特異的に結合するエンドソーム蛋白質の解析
- Author(s)
  高杉展正、新家瑠奈、上窪裕二、櫻井隆
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23300128
[Presentation] アデノシンA1受容体と代謝型グルタミン酸受容体の相互作用による小脳シナプス可塑性の制御
- Author(s)
  上窪裕二、櫻井隆
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PLANNED-22110007
[Presentation] APP-βCTFに特異的に結合するエンドソーム蛋白質の解析
- Author(s)
  高杉展正、新家瑠奈、上窪裕二、櫻井隆
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PLANNED-22110007
[Presentation] 海馬切片培養標本を用いたβ-セクレターゼの解析
- Author(s)
  上窪裕二、櫻井隆
- Organizer
  第36回日本神経科学大会 Neuro2013
- Place of Presentation
  京都
- Data Source
  KAKENHI-PLANNED-22110007

1. NUKINA Nobuyuki (10134595)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
2. KASHIYAMA Taku (90338343)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
3. NEMOTO Naoto (60509727)

# of Collaborated Projects: 3 results

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4. ARAYA Runa (10391848)

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5. KAMIKUBO Yuji (80509670)

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6. 清水輝夫 (00107666)

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7. 岩田淳 (40401038)

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8. INOUE Haruhisa (70332327)

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9. HIOKI Hiroyuki (00402850)

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10. EGAWA Naohiro (20534340)

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18. YANAGIHARA Nobuyuki (80140896)

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19. NAKAZATO Yoshikazu (60001525)

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32. MATSUMOTO Gen

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35. 富田泰輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 伊藤弦太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 岡本和樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 篠原寛明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 宮野加奈子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 上園保仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 橋本唯史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SAKURAI Takashi 櫻井 隆

櫻井 隆 サクライ タカシ

桜井 隆 サクライ タカシ

桜井 正樹 サクライ マサキ

Research Projects

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時空間制御・解析可能な変性神経突起再現モデルを用いたAβ-タウ病態関連機序の解明Principal Investigator

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in vitro変性神経突起モデルを用いたアルツハイマー病病態進展機序の解明Principal Investigator

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Early Alzheimer-like pathogenic events in endocytic membrane traffic in Down Syndrome iPSC-derived neuronsPrincipal Investigator

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Use of FALI with cDNA display single-domain antibodies for efficient functional screening of therapeutic targetsPrincipal Investigator

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Application of FALI with antibody-like scaffolds to the high-throughput functional proteomic screen for therapeutic targetsPrincipal Investigator

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Microdomain-dependent acceleration mechanisms for amyloidogenic processing of amyloid precursor protein induced by endocytic membrane traffic impairmentPrincipal Investigator

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Application of a cell-free protein display technology to the high-throughput functional proteomic screen for regulators of neuron-glia interactionPrincipal Investigator

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Understanding the neuronal dysfunction/neurocircuit pathology based on iPSC technology

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新規ミクロドメイン解析法を用いたアミロイド産生ー輸送連関機構の解明Principal Investigator

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A novel microdomain-dependent regulatory mechanism of amyloid precursor protein processingPrincipal Investigator

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光によるリアルタイム蛋白質不活化法を用いた神経-グリア相互作用新規解析法の開発Principal Investigator

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Study on cholesterol-dependent regulatory mechanisms of amyloid precursor protein processing in membrane microdomainsPrincipal Investigator

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Study on cholesterol-dependent regulatory mechanisms of amyloid precursor protein processing in lipid microdomainsPrincipal Investigator

SAKURAI Takashi 櫻井隆

櫻井隆サクライタカシ

桜井隆サクライタカシ

桜井正樹サクライマサキ

[Book] 分子から迫る神経薬理学　神経薬理学連載企画（平成25年4月号～平成26年3月号）2013