Wakimoto Toshiyuki 脇本敏幸

… Alternative Names

WAKIMOTO Toshiyuki 脇本敏幸

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Researcher Number	70363900
Other IDs
Affiliation (Current)	2025: 北海道大学, 薬学研究院, 教授
Affiliation (based on the past Project Information) *help	2016 – 2025: 北海道大学, 薬学研究院, 教授 2015 – 2016: 北海道大学, 薬学研究科(研究院), 教授 2014: 東京大学, 大学院薬学系研究科, 准教授 2012 – 2014: 東京大学, 薬学研究科(研究院), 准教授 2012: 東京大学, 大学院・薬学系研究科, 准教授 … More 2011: 東京大学, 大学院・薬学系研究科, 講師 2011: 東京大学, 薬学研究科(研究院), 講師 2011: 東京大学, 薬学研究科, 講師 2009: University of Shizuoka, 薬学部, 講師 2007 – 2008: University of Shizuoka, 薬学部, 助教 Less
Review Section/Research Field	Principal Investigator Biomolecular chemistry / Basic Section 47050:Environmental and natural pharmaceutical resources-related / Science and Engineering / Medium-sized Section 37:Biomolecular chemistry and related fields / Basic Section 47050:Environmental and natural pharmaceutical resources-related / Natural medicines / Transformative Research Areas, Section (II) / Living organism molecular science / Fisheries chemistry Except Principal Investigator Science and Engineering … More / Living organism molecular science / Basic Section 40040:Aquatic life science-related / Transformative Research Areas, Section (II) / Biomolecular chemistry Less
Keywords	Principal Investigator 生合成 / 海綿 / 海綿動物 / 海綿共生微生物 / Calyculin A / 二次代謝産物 / 共生微生物 / 生合成遺伝子 / メタゲノム / 環状ペプチド … More / 細胞毒性物質 / ペプチド / calyculin A / 生物活性物質 / ポリケタイド / カリクリンA / フラン脂肪酸 / 休眠遺伝子 / 生合成酵素 / 環化酵素 / ゲノム / 天然医薬品資源 / ゲノムマイニング / trans-AT PKS / 生理活性物質 / spongistatin / 海洋無脊椎動物 / 遺伝子クラスター / 共生菌 / NRPS / PKS / 難培養微生物 / 異種発現 / Entotheonella / 脱リン酸化 / リン酸化 / Theonella / Discodermia / 蛍光プローブ / チョコガタイシカイメン / タンパク質脱リン酸化酵素 / カリクリン / 抗炎症活性 / ミドリイガイ … More Except Principal Investigator 天然物化学 / 生合成工学 / 生合成 / 生物活性物質 / 生物分子科学 / 合成生物学 / 生合成リデザイン / 酵素 / 二次代謝酵素 / 機能制御 / 化学 / 行動 / コミュニケーション / 生理活性物質 / ケミカルエコロジー / 海洋生物学 / 化学生態学 / 甲殻類 / フェロモン / ケミカルコミュニケーション / 水産動物 / 化学感覚 / 情報科学 / 計算科学 / 有機合成 / 生物合成 / 国際交流 / 天然有機化合物 / 反応機構 / 生物分子化学 / 海洋天然薬物 / 採集調査 / 共生菌 / 海綿動物 / 生合成遺伝子 / 海洋天然物 / 酵素工学 / 物質生産 / 生合成クラスター / 遺伝子 / 多様性創出 / 遺伝子クラスター / メロテルペノイド / 天然物有機化学 / 海洋生物資源 Less

環状ペプチドの化学酵素合成による新規農薬モダリティの開拓Principal Investigator
- Principal Investigator
  
  脇本敏幸
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  Hokkaido University
Molecules that regulates mating behavior of crustaceans: diversity of pheromones and their functions
- Principal Investigator
  
  神尾道也
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 40040:Aquatic life science-related
- Research Institution
  Tokyo University of Marine Science and Technology
Search for new natural products derived from rare microorganismsPrincipal Investigator
- Principal Investigator
  
  脇本敏幸
- Project Period (FY)
  2023
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Hokkaido University
予知生合成科学・研究総括班
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  The University of Tokyo
新規ペプチド修飾酵素の機能拡張による大環状複雑骨格の創出Principal Investigator
- Principal Investigator
  
  脇本敏幸
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Hokkaido University
Genome mining of rare microbial strains for natural drug resourcesPrincipal Investigator
- Principal Investigator
  
  Wakimoto Toshiyuki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Hokkaido University
Biosynthetic gene cluster of bioactive natural products from marine invertebratesPrincipal Investigator
- Principal Investigator
  
  WAKIMOTO Toshiyuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Hokkaido University
Biosynthetic study on bioactive compounds from marine spongesPrincipal Investigator
- Principal Investigator
  
  脇本敏幸
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Natural medicines
- Research Institution
  Hokkaido University
Redesigning Biosynthetic Machineries (Project Team)
- Principal Investigator
  
  Abe Ikuro
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
Production of rare bioactive natural products originating from uncultured bacteriaPrincipal Investigator
- Principal Investigator
  
  WAKIMOTO Toshiyuki
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Hokkaido University
Redesigning Biosynthetic Machineries (International Activity Support Team)
- Principal Investigator
  
  Abe Ikuro
- Project Period (FY)
  2016 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
The mechanism regulating the function of a natural cytotoxinPrincipal Investigator
- Principal Investigator
  
  WAKIMOTO Toshiyuki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Hokkaido University
Bioactive secondary metabolites produced by sponge symbiont EntotheonellaPrincipal Investigator
- Principal Investigator
  
  WAKIMOTO Toshiyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Hokkaido University
Collection and survey of biosynthetic genes of spore-derived biologically active substances and clarification of biosynthetic machinery
- Principal Investigator
  
  Abe Ikuro
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  The University of Tokyo
Calyculin A生合成機構の解析Principal Investigator
- Principal Investigator
  
  脇本敏幸
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
Identification and genome analysis of bacterial symbiont producing sponge-derived secondary metabolitesPrincipal Investigator
- Principal Investigator
  
  WAKIMOTO Toshiyuki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biomolecular chemistry
- Research Institution
  The University of Tokyo
Enzyme engineering for natural product biosynthesis
- Principal Investigator
  
  ABE IKURO
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Living organism molecular science
- Research Institution
  The University of Tokyo
Development of selective phosphatase inhibitor based on calyculin APrincipal Investigator
- Principal Investigator
  
  TOSHIYUKI Wakimoto
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  The University of Tokyo
Studies on biosynthetic assembly line of meroterpenoids
- Principal Investigator
  
  ABE IKURO
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
Research for useful marineorganisms in Asia and Pacific regions
- Principal Investigator
  
  NAKAO Yoichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Waseda University
Studies on the biological activity of furan fatty acidsPrincipal Investigator
- Principal Investigator
  
  WAKIMOTO Toshiyuki
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Fisheries chemistry
- Research Institution
  University of Shizuoka

[Book] パートナー生薬学（改訂第4版）2021
- Author(s)
  竹谷　孝一、木内　文之、小松　かつ子、脇本　敏幸、他
- Total Pages
  458
- Publisher
  南江堂
- ISBN
  9784524403424
- Data Source
  KAKENHI-PLANNED-16H06448
[Book] パートナー天然物化学（改訂第4版）2021
- Author(s)
  海老塚　豊、森田　博史、阿部　郁朗、脇本　敏幸、他
- Total Pages
  306
- Publisher
  南江堂
- ISBN
  9784524403325
- Data Source
  KAKENHI-PLANNED-16H06448
[Book] パートナー生薬学（改訂第4版）2021
- Author(s)
  竹谷　孝一、木内　文之、小松　かつ子、脇本　敏幸、他
- Total Pages
  458
- Publisher
  南江堂
- ISBN
  9784524403424
- Data Source
  KAKENHI-PROJECT-18H02581
[Book] パートナー天然物化学（改訂第4版）2021
- Author(s)
  海老塚　豊、森田　博史、阿部　郁朗、脇本　敏幸、他
- Total Pages
  306
- Publisher
  南江堂
- ISBN
  9784524403325
- Data Source
  KAKENHI-PROJECT-18H02581
[Book] 「天然物の化学ー魅力と展望ー」上村大輔編, 科学のとびら602016
- Author(s)
  脇本敏幸
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PROJECT-15K12740
[Book] 「天然物の化学ー魅力と展望ー」上村大輔編2016
- Author(s)
  脇本敏幸
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PLANNED-16H06448
[Book] 天然物の化学ー魅力と展望ー」上村大輔編2016
- Author(s)
  脇本敏幸
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PROJECT-15H03112
[Book] Handbook of Anticancer Drug from Marine Origin2014
- Author(s)
  T. Wakimoto, K. C. Tan, H. Tajima, I. Abe
- Total Pages
  800
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-25560399
[Book] Handbook of Cytotoxic cyclic peptides from the marine sponges2014
- Author(s)
  T. Wakimoto, K. C. Tan, H. Tajima, I. Abe
- Total Pages
  800
- Publisher
  Springer
- Data Source
  KAKENHI-PUBLICLY-25108705
[Journal Article] Five New Analogs of Streptogramin Antibiotic Viridogrisein Isolated from <i>Streptomyces niveoruber</i>2024
- Author(s)
  Yoshimura Aya、Honda Takumi、Wakimoto Toshiyuki
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 72 Issue: 1 Pages: 80-85
- DOI
  10.1248/cpb.c23-00776
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2024-01-18
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K14368, KAKENHI-PROJECT-23KF0001, KAKENHI-PLANNED-22H05128, KAKENHI-PROJECT-21H02635
[Journal Article] Phylogeny‐guided Characterization of Bacterial Hydrazine Biosynthesis Mediated by Cupin/methionyl tRNA Synthetase‐like Enzymes2024
- Author(s)
  Matsuda Kenichi、Nakahara Yuto、Choirunnisa Atina Rizkiya、Arima Kuga、Wakimoto Toshiyuki
- Journal Title
  
  ChemBioChem
  
  Volume: 25 Issue: 7
- DOI
  10.1002/cbic.202300838
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K17410, KAKENHI-PROJECT-23KF0001, KAKENHI-PLANNED-22H05128, KAKENHI-PROJECT-21H02635
[Journal Article] Actinobacterial chalkophores: the biosynthesis of hazimycins2024
- Author(s)
  Matsuda Kenichi、Maruyama Hiroto、Imachi Kumiko、Ikeda Haruo、Wakimoto Toshiyuki
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: - Issue: 4 Pages: 228-237
- DOI
  10.1038/s41429-024-00706-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K17410, KAKENHI-PROJECT-23KF0001, KAKENHI-PLANNED-22H05128, KAKENHI-PROJECT-21H02635
[Journal Article] 細胞外膜小胞を介した異種細菌間相互作用による二次代謝産物の生産誘導2024
- Author(s)
  吉村彩、脇本敏幸
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 82
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23KF0001
[Journal Article] 細胞外膜小胞を介した異種細菌間相互作用による二次代謝産物の生産誘導2024
- Author(s)
  吉村彩、脇本敏幸
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 82 Pages: 167-169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02635
[Journal Article] Chemoenzymatic tandem cyclization for the facile synthesis of bicyclic peptides2024
- Author(s)
  Kobayashi Masakazu、Onozawa Naho、Matsuda Kenichi、Wakimoto Toshiyuki
- Journal Title
  
  Communications Chemistry
  
  Volume: 7 Issue: 1 Pages: 67-67
- DOI
  10.1038/s42004-024-01147-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K17410, KAKENHI-PROJECT-22KJ0097, KAKENHI-PROJECT-23KF0001, KAKENHI-PLANNED-22H05128, KAKENHI-PROJECT-21H02635
[Journal Article] New variochelins from soil-isolated Variovorax sp. H0022024
- Author(s)
  Haedar Jabal Rahmat、Yoshimura Aya、Wakimoto Toshiyuki
- Journal Title
  
  Beilstein Journal of Organic Chemistry
  
  Volume: 20 Pages: 692-700
- DOI
  10.3762/bjoc.20.63
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14368, KAKENHI-PROJECT-23KF0001, KAKENHI-PROJECT-21H02635
[Journal Article] 細胞外膜小胞を介した異種菌間相互作用による二次代謝産物の生産誘導2024
- Author(s)
  吉村彩、脇本敏幸
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 82 Pages: 167-169
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22H05128
[Journal Article] Bacterial Hydrazine Biosynthetic Pathways Featuring Cupin/Methionyl tRNA Synthetase‐like Enzymes2024
- Author(s)
  Matsuda Kenichi、Wakimoto Toshiyuki
- Journal Title
  
  ChemBioChem
  
  Volume: - Issue: 9
- DOI
  10.1002/cbic.202300874
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K17410, KAKENHI-PROJECT-23KF0001, KAKENHI-PLANNED-22H05128, KAKENHI-PROJECT-21H02635
[Journal Article] Membrane‐Vesicle‐Mediated Interbacterial Communication Activates Silent Secondary Metabolite Production2023
- Author(s)
  Yoshimura Aya、Saeki Rio、Nakada Ryusuke、Tomimoto Shota、Jomori Takahiro、Suganuma Keisuke、Wakimoto Toshiyuki
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 62 Issue: 42 Pages: 1-9
- DOI
  10.1002/anie.202307304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K14368, KAKENHI-PROJECT-23KF0001, KAKENHI-PLANNED-22H05128, KAKENHI-PROJECT-21H02635
[Journal Article] ペニシリン結合タンパク質型チオエステラーゼを用いた環状ペプチドの効率的な化学-酵素合成2023
- Author(s)
  松田研一、脇本敏幸
- Journal Title
  
  Peptide Newsletter Japan
  
  Volume: 129 Pages: 4-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23KF0001
[Journal Article] ペニシリン結合タンパク質型チオエステラーゼを用いた環状ペプチドの効率的な化学-酵素合成2023
- Author(s)
  松田研一、脇本敏幸
- Journal Title
  
  Peptide Newsletter Japan
  
  Volume: 129 Pages: 4-7
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22H05128
[Journal Article] Streamlined chemoenzymatic synthesis of cyclic peptides by non-ribosomal peptide cyclases2023
- Author(s)
  Kobayashi, M., Fujita, K., Matsuda, K.*, Wakimoto, T.*
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 145 Issue: 6 Pages: 3270-3275
- DOI
  10.1021/jacs.2c11082
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15302, KAKENHI-PLANNED-22H05128, KAKENHI-PROJECT-21H02635, KAKENHI-PROJECT-22KJ0097
[Journal Article] Carrier Protein Mediated Formation of the Dihydropyridazinone Ring in Actinopyridazinone Biosynthesis2023
- Author(s)
  Arima Kuga、Akiyama Satoko、Shin‐ya Kazuo、Matsuda Kenichi、Wakimoto Toshiyuki
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 62 Issue: 29
- DOI
  10.1002/anie.202305155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K17410, KAKENHI-PROJECT-23KF0001, KAKENHI-PLANNED-22H05128, KAKENHI-PROJECT-21H02635
[Journal Article] ペニシリン結合タンパク質型チオエステラーゼを用いた環状ペプチドの効率的な化学-酵素合成2023
- Author(s)
  松田研一、脇本敏幸
- Journal Title
  
  Peptide Newsletter Japan
  
  Volume: 129 Pages: 4-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02635
[Journal Article] Biosynthesis of Bioactive Natural Products Derived from Theonellidae Family Marine Sponges2023
- Author(s)
  Wakimoto Toshiyuki
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 71 Issue: 1 Pages: 1-8
- DOI
  10.1248/cpb.c22-00715
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2023-01-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22H05128, KAKENHI-PROJECT-21H02635
[Journal Article] Animal-associated marine Acidobacteria with a rich natural-product repertoire2023
- Author(s)
  Leopold-Messer Stefan、Chepkirui Clara、Mabesoone Mathijs F.J.、Meyer Joshua、Paoli Lucas、Sunagawa Shinichi、Uria Agustinus R.、Wakimoto Toshiyuki、Piel Joern
- Journal Title
  
  Chem (Cell Press journal)
  
  Volume: 9 Issue: 12 Pages: 3696-3713
- DOI
  10.1016/j.chempr.2023.11.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06612, KAKENHI-PROJECT-23KF0001, KAKENHI-PLANNED-22H05128, KAKENHI-PROJECT-21H02635
[Journal Article] Characterization of the surugamide biosynthetic gene cluster of TUA-NKU25, a Streptomyces diastaticus strain isolated from Kusaya and its effects on salt-dependent growth2022
- Author(s)
  Takeuchi, A., Hirata, A., Teshima, A., Ueki, M., Satoh, T., Matsuda, K., Wakimoto, T., Arakawa, K., Ishikawa, M., Suzuki, T.
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 87 Issue: 3 Pages: 320-329
- DOI
  10.1093/bbb/zbac201
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15302, KAKENHI-PLANNED-22H05128, KAKENHI-PROJECT-21H02635, KAKENHI-PROJECT-19KK0149, KAKENHI-PROJECT-23K23541
[Journal Article] 海綿共生微生物による細胞毒性物質の活性化機構2022
- Author(s)
  城森啓宏、脇本敏幸
- Journal Title
  
  化学と生物
  
  Volume: 60 Pages: 621-623
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02635
[Journal Article] A Natural Dihydropyridazinone Scaffold Generated from a Unique Substrate for a Hydrazine-Forming Enzyme2022
- Author(s)
  Matsuda, K.*, Arima, K., Akiyama, S., Yamada, Y., Abe, Y., Suenaga, H., Hashimoto, J., Shin-ya, K., Nishiyama, M., Wakimoto, T.*
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 144 Issue: 28 Pages: 12954-12960
- DOI
  10.1021/jacs.2c05269
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15302, KAKENHI-PLANNED-22H05128, KAKENHI-PROJECT-21H02635
[Journal Article] ペプチド環化反応を触媒する新しい酵素ファミリー「PBP-type TE」の発見と機能解析2022
- Author(s)
  松田研一、脇本敏幸
- Journal Title
  
  アグリバイオ
  
  Volume: 6 Pages: 734-739
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22H05128
[Journal Article] New Theonellapeptolides from Indonesian Marine Sponge Theonella swinhoei as Anti-Austerity Agents2022
- Author(s)
  Haedar Jabal Rahmat、Uria Agustinus Robert、Lallo Subehan、Dibwe Dya Fita、Wakimoto Toshiyuki
- Journal Title
  
  Marine Drugs (MDPI)
  
  Volume: 20 Issue: 11 Pages: 661-661
- DOI
  10.3390/md20110661
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06612, KAKENHI-PLANNED-22H05128, KAKENHI-PROJECT-21H02635
[Journal Article] New azodyrecins identified by a genome mining-directed reactivity-based screening2022
- Author(s)
  Choirunnisa, A. R.#, Arima, K.#, Abe, Y., Kagaya, N., Kudo, K., Suenaga, H., Hashimoto, J., Fujie, M., Satoh, N., Shin-ya, N., Matsuda, K.*, Wakimoto, T.*
- Journal Title
  
  Beilstein Journal of Organic Chemistry
  
  Volume: 18 Pages: 1017-1025
- DOI
  10.3762/bjoc.18.102
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15302, KAKENHI-PLANNED-22H05128, KAKENHI-PROJECT-21H02635
[Journal Article] Argicyclamides A?C Unveil Enzymatic Basis for Guanidine Bis-prenylation2021
- Author(s)
  Phan Chin-Soon、Matsuda Kenichi、Balloo Nandani、Fujita Kei、Wakimoto Toshiyuki、Okino Tatsufumi
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 143 Issue: 27 Pages: 10083-10087
- DOI
  10.1021/jacs.1c05732
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16390, KAKENHI-PROJECT-21H02635
[Journal Article] PenA, a penicillin-binding protein-type thioesterase specialized for small peptide cyclization2021
- Author(s)
  Matsuda Kenichi、Fujita Kei、Wakimoto Toshiyuki
- Journal Title
  
  Journal of Industrial Microbiology and Biotechnology
  
  Volume: kuab023 Issue: 3-4
- DOI
  10.1093/jimb/kuab023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16390, KAKENHI-PLANNED-16H06448, KAKENHI-PROJECT-18H02581, KAKENHI-PROJECT-21H02635
[Journal Article] Insights into phosphatase-activated chemical defense in a marine sponge holobiont2021
- Author(s)
  Jomori Takahiro、Matsuda Kenichi、Egami Yoko、Abe Ikuro、Takai Akira、Wakimoto Toshiyuki
- Journal Title
  
  RSC Chemical Biology
  
  Volume: 2 Issue: 6 Pages: 1600-1607
- DOI
  10.1039/d1cb00163a
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16390, KAKENHI-PROJECT-21H02635, KAKENHI-PROJECT-20H00490
[Journal Article] 新規ペプチド環化酵素PBP-type TEの発見と機能解析2021
- Author(s)
  松田研一、脇本敏幸
- Journal Title
  
  月刊ファインケミカル
  
  Volume: 50 Pages: 5-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02635
[Journal Article] 新規ペプチド環化酵素PBP-type TEの発見と機能解析2021
- Author(s)
  松田研一、脇本敏幸
- Journal Title
  
  ファインケミカル
  
  Volume: -
- Data Source
  KAKENHI-PROJECT-18H02581
[Journal Article] Geographical parthenogenesis in the brown alga Scytosiphon lomentaria (Scytosiphonaceae): Sexuals in warm waters and parthenogens in cold waters2021
- Author(s)
  Hoshino Masakazu, Hiruta Shimpei F., Croce Maria Emilia, Kamiya Mitsunobu, Jomori Takahiro, Wakimoto Toshiyuki & Kogame Kazuhiro
- Journal Title
  
  Molecular Ecology
  
  Volume: 30 Issue: 22 Pages: 5814-5830
- DOI
  10.1111/mec.16152
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06806, KAKENHI-PROJECT-21H02635, KAKENHI-PROJECT-19K06817
[Journal Article] Ascidian-associated photosymbionts originated from Manado, Indonesia: Secondary metabolite identification, bioactivity simulation, and biosynthetic insight2021
- Author(s)
  Rumengan Inneke F.M.、 Roring Vera I.Y.、Haedar Jabal R.、 Siby Mayse S.、Luntungan Aldian H.、Kolondam Beivy J.、Uria Agustinus R.、Wakimoto Toshiyuki
- Journal Title
  
  Symbiosis
  
  Volume: - Issue: 1 Pages: 71-82
- DOI
  10.1007/s13199-021-00766-4
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06448, KAKENHI-PROJECT-18H02581, KAKENHI-PROJECT-21H02635, KAKENHI-PROJECT-21K06612
[Journal Article] 新規ペプチド環化酵素PBP-type TEの発見と機能解析2021
- Author(s)
  松田研一、脇本敏幸
- Journal Title
  
  ファインケミカル
  
  Volume: -
- Data Source
  KAKENHI-PLANNED-16H06448
[Journal Article] Heterochiral coupling in non-ribosomal peptide macrolactamization2020
- Author(s)
  Matsuda Kenichi、Zhai Rui、Mori Takahiro、Kobayashi Masakazu、Sano Ayae、Abe Ikuro、Wakimoto Toshiyuki
- Journal Title
  
  Nature Catalysis
  
  Volume: 3 Issue: 6 Pages: 507-515
- DOI
  10.1038/s41929-020-0456-7
- NAID
  120006941707
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16390, KAKENHI-PLANNED-16H06443, KAKENHI-PLANNED-16H06448, KAKENHI-PROJECT-18H02581, KAKENHI-PROJECT-20H00490
[Journal Article] Polyketides Biosynthesis in Marine Sponges of the Family Theonellidae2020
- Author(s)
  Uria Agustinus R.、Wakimoto Toshiyuki
- Journal Title
  
  Topics in Heterocyclic Chemistry
  
  Volume: - Pages: 1-25
- DOI
  10.1007/7081_2020_48
- ISBN
  9789811646362, 9789811646379
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06448, KAKENHI-PROJECT-18H02581
[Journal Article] Total Synthesis and Structural Revision of Kasumigamide, and Identification of a New Analogue2020
- Author(s)
  Kuranaga Takefumi、Matsuda Kenichi、Takaoka Masachika、Tachikawa Chisato、Sano Ayae、Itoh Kosei、Enomoto Ayumu、Fujita Kei、Abe Ikuro、Wakimoto Toshiyuki
- Journal Title
  
  ChemBioChem
  
  Volume: 21 Issue: 23 Pages: 3329-3332
- DOI
  10.1002/cbic.202000409
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16390, KAKENHI-PLANNED-16H06443, KAKENHI-PLANNED-16H06448, KAKENHI-PROJECT-18H02581, KAKENHI-PROJECT-20H00490
[Journal Article] Crystal Structures of Flavone <i>C</i>-Glycosides from Oolong Tea Leaves: Chafuroside A Dihydrate and Chafuroside B Monohydrate2019
- Author(s)
  Iwao Yasunori、 Ishida Hitoshi、Kimura Shin-ichiro、Wakimoto Toshiyuki、Kondo Hiromu、Itai Shigeru、Noguchi Shuji
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 67 Issue: 9 Pages: 935-939
- DOI
  10.1248/cpb.c19-00166
- NAID
  130007699653
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2019-09-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06448, KAKENHI-PROJECT-18H02581, KAKENHI-PROJECT-17K08467
[Journal Article] 非リボソーム依存性ペプチド生合成における新規環化酵素の発見2019
- Author(s)
  松田研一、倉永健史、脇本敏幸
- Journal Title
  
  Farumashia
  
  Volume: 55 Issue: 7 Pages: 650-654
- DOI
  10.14894/faruawpsj.55.7_650
- NAID
  130007671605
- ISSN
  0014-8601, 2189-7026
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16390, KAKENHI-PLANNED-16H06448, KAKENHI-PROJECT-18H02581, KAKENHI-PROJECT-18K14396
[Journal Article] The revised structure of surugamide A2019
- Author(s)
  Matsuda Kenichi、Kuranaga Takefumi、Ayae Sano, Akihiro Ninomiya、Takada Kentaros、Wakimoto Toshiyuki
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06448
[Journal Article] The Revised Structure of the Cyclic Octapeptide Surugamide A2019
- Author(s)
  Matsuda Kenichi、Kuranaga Takefumi、Sano Ayae、Ninomiya Akihiro、Takada Kentaro、Wakimoto Toshiyuki
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 67 Issue: 5 Pages: 476-480
- DOI
  10.1248/cpb.c19-00002
- NAID
  130007641158
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2019-05-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16390, KAKENHI-PLANNED-16H06448, KAKENHI-PROJECT-16H04980, KAKENHI-PROJECT-18H02581, KAKENHI-PROJECT-18K14396
[Journal Article] SurE is a trans-acting thioesterase cyclizing two distinct non-ribosomal peptides2019
- Author(s)
  Matsuda, K., Kobayashi, M., Kuranaga, T., Takagda, K., Ikeda, H., Matsunaga, S., Wakimoto, T.,
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 17 Issue: 5 Pages: 1058-1061
- DOI
  10.1039/c8ob02867b
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06447, KAKENHI-PLANNED-16H06448, KAKENHI-PROJECT-18H02581, KAKENHI-PROJECT-17F17114, KAKENHI-PROJECT-19K16390, KAKENHI-PROJECT-18K14396
[Journal Article] バクテリアが有する新たな非リボソームペプチド環化酵素2019
- Author(s)
  松田研一、脇本敏幸
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 77 Pages: 306-307
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06448
[Journal Article] The revised structure of surugamide A2019
- Author(s)
  Matsuda Kenichi、Kuranaga Takefumi、Ayae Sano, Akihiro Ninomiya、Takada Kentaros、Wakimoto Toshiyuki
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17F17114
[Journal Article] The revised structure of surugamide A2019
- Author(s)
  Matsuda Kenichi、Kuranaga Takefumi、Ayae Sano, Akihiro Ninomiya、Takada Kentaros、Wakimoto Toshiyuki
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: ー
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02581
[Journal Article] バクテリアが有する新たな非リボソームペプチド環化酵素2019
- Author(s)
  松田研一、脇本敏幸
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 77 Pages: 306-307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02581
[Journal Article] A New Cyclase Family Catalyzing Head-to-Tail Macrolactamization of Non-ribosomal Peptides2019
- Author(s)
  Matsuda Kenichi、Kuranaga Takefumi、Wakimoto Toshiyuki
- Journal Title
  
  Journal of Synthetic Organic Chemistry, Japan
  
  Volume: 77 Issue: 11 Pages: 1106-1115
- DOI
  10.5059/yukigoseikyokaishi.77.1106
- NAID
  130007742538
- ISSN
  0037-9980, 1883-6526
- Year and Date
  2019-11-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16390, KAKENHI-PLANNED-16H06448, KAKENHI-PROJECT-18H02581, KAKENHI-PROJECT-18K14396
[Journal Article] Scrobiculosides A and B from the deep-sea sponge Pachastrella scrobiculosa2019
- Author(s)
  Jomori Takahiro、Ise Yuji、Kohtsuka Hisanori、Matsuda Kenichi、Kuranaga Takefumi、Wakimoto Toshiyuki
- Journal Title
  
  Journal of Natural Medicine
  
  Volume: 73 Issue: 4 Pages: 1058-1061
- DOI
  10.1007/s11418-019-01315-6
- NAID
  40021995195
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06448, KAKENHI-PROJECT-18H02581, KAKENHI-PROJECT-18K14396
[Journal Article] Diastereoselective Total Synthesis and Structural Confirmation of Surugamide F2018
- Author(s)
  Kuranaga Takefumi、Fukuba Atsuki、Ninomiya Akihiro、Takada Kentaro、Matsunaga Shigeki、Wakimoto Toshiyuki
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 66 Issue: 6 Pages: 637-641
- DOI
  10.1248/cpb.c18-00072
- NAID
  130007382323
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2018-06-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06448, KAKENHI-PROJECT-18H02581, KAKENHI-PROJECT-17F17114
[Journal Article] Total Synthesis of the Nonribosomal Peptide Surugamide?B and Identification of a New Offloading Cyclase Family2018
- Author(s)
  Kuranaga Takefumi、Matsuda Kenichi、Sano Ayae、Kobayashi Masakazu、Ninomiya Akihiro、Takada Kentaro、Matsunaga Shigeki、Wakimoto Toshiyuki
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 57 Issue: 30 Pages: 9447-9451
- DOI
  10.1002/anie.201805541
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14396, KAKENHI-PLANNED-16H06448, KAKENHI-PROJECT-18H02581, KAKENHI-PROJECT-17F17114
[Journal Article] Diastereoselective total synthesis and structural confirmation of surugamide F2018
- Author(s)
  Kuranaga Takefumi、Fukuba Atsuki、Ninomiya Akihiro、Takada Kentaro、Matsunaga Shigeki、Wakimoto Toshiyuki
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 66
- NAID
  130007382323
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H03112
[Journal Article] Biosynthetic insights of calyculin- and misakinolide-type compounds in “Candidatus Entotheonella sp.”2018
- Author(s)
  Uria Agustinus、Piel Joern、Wakimoto Toshiyuki
- Journal Title
  
  Methods in Enzymology
  
  Volume: 604
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17F17114
[Journal Article] Biosynthetic Insights of Calyculin- and Misakinolide-Type Compounds in “ Candidatus Entotheonella sp.”2018
- Author(s)
  Uria Agustinus R.、Piel Joern、Wakimoto Toshiyuki
- Journal Title
  
  Methods in Enzymology
  
  Volume: 604 Pages: 287-330
- DOI
  10.1016/bs.mie.2018.02.017
- ISBN
  9780128139592
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06448, KAKENHI-PROJECT-18H02581, KAKENHI-PROJECT-17F17114
[Journal Article] Biosynthetic insights of calyculin- and misakinolide-type compounds in “Candidatus Entotheonella sp.”2018
- Author(s)
  Uria Agustinus、Piel Joern、Wakimoto Toshiyuki
- Journal Title
  
  Methods in Enzymology
  
  Volume: 604
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06448
[Journal Article] Diastereoselective total synthesis and structural confirmation of surugamide F2018
- Author(s)
  Kuranaga Takefumi、Fukuba Atsuki、Ninomiya Akihiro、Takada Kentaro、Matsunaga Shigeki、Wakimoto Toshiyuki
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 66
- NAID
  130007382323
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06448
[Journal Article] Biosynthetic insights of calyculin- and misakinolide-type compounds in “Candidatus Entotheonella sp.”2018
- Author(s)
  Uria Agustinus、Piel Joern、Wakimoto Toshiyuki
- Journal Title
  
  Methods in Enzymology
  
  Volume: 604
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03112
[Journal Article] Diastereoselective total synthesis and structural confirmation of surugamide F2018
- Author(s)
  Kuranaga Takefumi、Fukuba Atsuki、Ninomiya Akihiro、Takada Kentaro、Matsunaga Shigeki、Wakimoto Toshiyuki
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 66
- NAID
  130007382323
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17F17114
[Journal Article] Discovery of Unprecedented Hydrazine-Forming Machinery in Bacteria2018
- Author(s)
  Matsuda Kenichi、Tomita Takeo、Shin-ya Kazuo、Wakimoto Toshiyuki、Kuzuyama Tomohisa、Nishiyama Makoto
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 140 Issue: 29 Pages: 9083-9086
- DOI
  10.1021/jacs.8b05354
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06448, KAKENHI-PLANNED-16H06453, KAKENHI-PROJECT-17H06168, KAKENHI-PROJECT-18H02581, KAKENHI-PROJECT-17F17114
[Journal Article] Protein phosphatases 1 and 2A and their naturally occurring inhibitors: current topics in smooth muscle physiology and chemical biology2017
- Author(s)
  Takai Akira、Eto Masumi、Hirano Katsuya、Takeya Kosuke、Wakimoto Toshiyuki、Watanabe Masaru
- Journal Title
  
  J Physiol Sci
  
  Volume: 68 Issue: 1 Pages: 1-17
- DOI
  10.1007/s12576-017-0556-6
- NAID
  40021443577
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09518, KAKENHI-PLANNED-16H06448, KAKENHI-PROJECT-15H03112, KAKENHI-PROJECT-17F17114
[Journal Article] Identification of pyridinium with three indole moieties as an antimicrobial agent2017
- Author(s)
  Okada, M., Sugita, T., Wong, C. P., Wakimoto, T., Abe, I.
- Journal Title
  
  J. Nat. Prod.,
  
  Volume: 80 Issue: 4 Pages: 1205-1209
- DOI
  10.1021/acs.jnatprod.6b01152
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H03112, KAKENHI-PROJECT-15K12740, KAKENHI-PROJECT-26303005, KAKENHI-PLANNED-16H06443, KAKENHI-PLANNED-16H06448, KAKENHI-PUBLICLY-17H05429, KAKENHI-PROJECT-15H01836, KAKENHI-PROJECT-17F17114
[Journal Article] Characterization of giant modular PKSs provides insight into genetic mechanism for structural diversification of aminopolyol polyketides2017
- Author(s)
  Zhang, L., Hashimoto, T., Qin, B., Hashimoto, J., Kozone, I., Kawahara, T., Okada, M., Awakawa, T., Ito, T., Asakawa, Y., Ueki, M., Takahashi, S., Osada, H., Wakimoto, T., Ikeda, H., Shin-ya, K., Abe, I.
- Journal Title
  
  Angew. Chem. Int. Ed.
  
  Volume: 56 Issue: 7 Pages: 1740-1745
- DOI
  10.1002/anie.201611371
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-16H06443, KAKENHI-PLANNED-16H06447, KAKENHI-PLANNED-16H06448, KAKENHI-PROJECT-15H01836, KAKENHI-PROJECT-15H03112, KAKENHI-PROJECT-24688011, KAKENHI-PROJECT-15K12740, KAKENHI-PROJECT-25660085, KAKENHI-PROJECT-16K13084, KAKENHI-PROJECT-16H04905, KAKENHI-PROJECT-17F17114
[Journal Article] Toward dark matter of natural products”2017
- Author(s)
  Wakimoto, T.
- Journal Title
  
  Chem. Rec.
  
  Volume: 17 Issue: 11 Pages: 1124-1134
- DOI
  10.1002/tcr.201700009
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-16H06448, KAKENHI-PROJECT-15H03112, KAKENHI-PROJECT-15K12740, KAKENHI-PROJECT-17F17114
[Journal Article] Total synthesis of theonellapeptolide Id2017
- Author(s)
  Kuranaga, T., Enomoto, A., Tan, H., Fujita, K., Wakimoto, T.
- Journal Title
  
  Org. Lett.
  
  Volume: 19 Issue: 6 Pages: 1366-1369
- DOI
  10.1021/acs.orglett.7b00249
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-16H06448, KAKENHI-PROJECT-15H03112, KAKENHI-PROJECT-15K12740, KAKENHI-PROJECT-26303005, KAKENHI-PROJECT-17F17114
[Journal Article] 海綿共生微生物による生物活性物質の生産2016
- Author(s)
  江上蓉子, 脇本敏幸, 阿部郁朗
- Journal Title
  
  バイオインダストリー,
  
  Volume: 33 Pages: 11-17
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26303005
[Journal Article] Structural diversification of lyngbyatoxin A by host-dependent heterologous expression of the tleABC biosynthetic gene cluster2016
- Author(s)
  Zhang, L., Hoshino, S., Awakawa, T., Wakimoto, T., Abe, I.
- Journal Title
  
  ChemBioChem
  
  Volume: 17 Issue: 15 Pages: 1407-1411
- DOI
  10.1002/cbic.201600229
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-16H06448, KAKENHI-PROJECT-15H03112, KAKENHI-PROJECT-16J01117
[Journal Article] 海綿共生微生物による生物活性物質の生産2016
- Author(s)
  江上蓉子, 脇本敏幸, 阿部郁朗
- Journal Title
  
  バイオインダストリー
  
  Volume: 33 Pages: 11-17
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-16H06448
[Journal Article] An unusual chimeric diterpene synthase from Emericella varicolor and its functional conversion into a sesterterpene synthase by domain swapping2016
- Author(s)
  B. Qin, Y. Matsuda, T. Mori, M. Okada, Z. Quan, T. Mitsuhashi, T. Wakimoto, I. Abe
- Journal Title
  
  Angew. Chem. Int. Ed.
  
  Volume: 55 Issue: 5 Pages: 1658-1661
- DOI
  10.1002/anie.201509263
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K12740, KAKENHI-PROJECT-15H03112, KAKENHI-PLANNED-16H06443, KAKENHI-PLANNED-16H06448, KAKENHI-PROJECT-15H01836, KAKENHI-PROJECT-24688011
[Journal Article] Syntheses of methylated catechins and theaflavins using the Ns group to protect and deactivate the phenol2016
- Author(s)
  T. Asakawa, Y. Kawabe, A. Yoshida, Y. Aihara, T. Manabe, Y. Hirose, A. Sakurada, M. Inai, Y. Hamashima, T. Furuta, T. Wakimoto, T. Kan
- Journal Title
  
  J. Antibiot.
  
  Volume: 69 Issue: 4 Pages: 299-312
- DOI
  10.1038/ja.2016.14
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-16H01160, KAKENHI-PLANNED-16H06448, KAKENHI-PROJECT-15H03112, KAKENHI-PROJECT-15K12740
[Journal Article] Metagenomic analysis of the sponge Discodermia reveals the production of the cyanobacterial natural product kasumigamide by 'Entotheonella'2016
- Author(s)
  Nakashima, Y., Egami, Y., Kimura, M., Wakimoto, T., Abe, I.
- Journal Title
  
  PLoS ONE
  
  Volume: 11 Issue: 10 Pages: e0164468-e0164468
- DOI
  10.1371/journal.pone.0164468
- NAID
  120005893293
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-16H06448, KAKENHI-PROJECT-15H03112, KAKENHI-PROJECT-15H05996, KAKENHI-PROJECT-15J12340, KAKENHI-PROJECT-26303005, KAKENHI-PROJECT-15K12740
[Journal Article] Concise synthesis of anserine: efficient solvent tuning in asymmetric hydrogenation reaction2016
- Author(s)
  M. Yamashita, K. Shimizu, Y. Koizumi, T. Wakimotoa, Y. Hamashima, T. Asakawa, M. Inai, T. Kan
- Journal Title
  
  Synlet
  
  Volume: 27 Issue: 19 Pages: 2734-2736
- DOI
  10.1055/s-0035-1562796
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-16H01160, KAKENHI-PLANNED-16H06448, KAKENHI-PROJECT-15H03112, KAKENHI-PROJECT-15K12740
[Journal Article] Calyculin: Nature’s way of making the sponge-derived cytotoxin2016
- Author(s)
  T. Wakimoto, Y. Egami, I. Abe
- Journal Title
  
  Nat. Prod. Rep.
  
  Volume: 未定 Issue: 6 Pages: 751-760
- DOI
  10.1039/c5np00123d
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K12740, KAKENHI-PROJECT-15H03112, KAKENHI-PROJECT-15H05996, KAKENHI-PLANNED-16H06443, KAKENHI-PLANNED-16H06448, KAKENHI-PROJECT-15H01836, KAKENHI-PROJECT-26303005
[Journal Article] Sulfoureido lipopeptides from the marine sponge Discodermia kiiensis2016
- Author(s)
  Tan, K. C., Wakimoto, T., Abe, I.
- Journal Title
  
  J. Nat. Prod.
  
  Volume: 79 Issue: 9 Pages: 2418-2422
- DOI
  10.1021/acs.jnatprod.6b00586
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-16H06448, KAKENHI-PROJECT-15H03112, KAKENHI-PROJECT-26303005, KAKENHI-PROJECT-15K12740
[Journal Article] 海綿共生微生物による生物活性物質の生産2016
- Author(s)
  江上蓉子, 脇本敏幸, 阿部郁朗
- Journal Title
  
  バイオインダストリー
  
  Volume: 33 Pages: 11-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H03112
[Journal Article] 海綿共生微生物による生物活性物質の生産2016
- Author(s)
  江上蓉子, 脇本敏幸, 阿部郁朗
- Journal Title
  
  バイオインダストリー
  
  Volume: 33 Pages: 11-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K12740
[Journal Article] Biosynthetic gene cluster for surugamide A encompasses an unrelated decapeptide, surugamide F2016
- Author(s)
  Ninomiya, A., Katsuyama, Y., Kuranaga, T., Miyazaki, M., Nogi, Y., Okada, S., Wakimoto, T., Ohnishi, Y., Matsunaga, S., Takada, K.
- Journal Title
  
  ChemBioChem
  
  Volume: 17 Issue: 18 Pages: 1709-1712
- DOI
  10.1002/cbic.201600350
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-16H06448, KAKENHI-PROJECT-15H03112, KAKENHI-PROJECT-16H04980, KAKENHI-PROJECT-15K12740
[Journal Article] Structural basis for the β-carboline alkaloids production by the microbial homodimeric enzyme McbB2015
- Author(s)
  T. Mori, S. Hoshino, S. Sahashi, T. Wakimoto, T. Matsui, H. Morita, I. Abe
- Journal Title
  
  Chem. Biol.
  
  Volume: 17 Issue: 7 Pages: 1501-1504
- DOI
  10.1016/j.chembiol.2015.06.006
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12740, KAKENHI-PROJECT-25242067, KAKENHI-PROJECT-15H03112, KAKENHI-PROJECT-26282210, KAKENHI-PROJECT-15H01836
[Journal Article] カイメンー共生バクテリア系の化学防御機構2015
- Author(s)
  脇本敏幸, 阿部郁朗
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 73 Pages: 49-51
- Data Source
  KAKENHI-PROJECT-26303005
[Journal Article] カイメンー共生バクテリア系の化学防御機2015
- Author(s)
  脇本敏幸, 阿部郁朗
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 34 Pages: 49-51
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26303005
[Journal Article] 海綿動物の化学防御を担う共生細菌2015
- Author(s)
  江上蓉子、脇本敏幸、阿部郁朗
- Journal Title
  
  細胞工学
  
  Volume: 34 Pages: 412-416
- NAID
  40020416788
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H03112
[Journal Article] Production of indole antibiotics induced by exogenous gene derived from sponge metagenome2015
- Author(s)
  Y. Takeshige, Y. Egami, T. Wakimoto, I. Abe
- Journal Title
  
  Mol. BioSyst.
  
  Volume: 11 Issue: 5 Pages: 1290-1294
- DOI
  10.1039/c5mb00131e
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K12740, KAKENHI-PROJECT-15H03112, KAKENHI-PROJECT-13J10253, KAKENHI-PROJECT-26303005
[Journal Article] 海綿動物の化学防御を担う共生細菌2015
- Author(s)
  江上蓉子、脇本敏幸、阿部郁朗
- Journal Title
  
  細胞工学
  
  Volume: 34 Pages: 412-416
- NAID
  40020416788
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K12740
[Journal Article] Chojalactones A-C, Cytotoxic Butanolides Isolated from Streptomyces sp. Cultivated with Mycolic Acid Containing Bacterium.2015
- Author(s)
  Hoshino S, Wakimoto T, Onaka H, Abe I.
- Journal Title
  
  Org Lett.
  
  Volume: 印刷中 Issue: 6 Pages: 1501-1504
- DOI
  10.1021/acs.orglett.5b00385
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25292046, KAKENHI-PROJECT-15K12740, KAKENHI-PROJECT-15H03112
[Journal Article] Niizalactams A-C, multicyclic macrolactams isolated from combined culture of Streptomyces with mycolic acid-containing bacterium2015
- Author(s)
  S. Hoshino, M. Okada, T. Wakimoto, H. Zhang, F. Hayashi, H. Onaka, I. Abe
- Journal Title
  
  J. Nat. Prod.
  
  Volume: 78 Issue: 12 Pages: 3011-3017
- DOI
  10.1021/acs.jnatprod.5b00804
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K12740, KAKENHI-PROJECT-15H03112, KAKENHI-PROJECT-25292046, KAKENHI-PROJECT-24688011
[Journal Article] Uncovering the unusual D-ring construction in terretonin biosynthesis by collaboration of a multifunctional cytochrome P450 and a unique isomerase2015
- Author(s)
  Matsuda, Y., Iwabuchi, T., Wakimoto, T., Awakawa, T., Abe, I.
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 137 Issue: 9 Pages: 3393-3401
- DOI
  10.1021/jacs.5b00570
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-22108004, KAKENHI-PROJECT-23241068, KAKENHI-PROJECT-26560428, KAKENHI-PROJECT-15K12740, KAKENHI-PROJECT-15H03112, KAKENHI-PROJECT-15H01836
[Journal Article] 海綿動物の化学防御を担う共生細菌2015
- Author(s)
  江上蓉子, 脇本敏幸, 阿部郁朗
- Journal Title
  
  細胞工学
  
  Volume: 34 Pages: 412-416
- NAID
  40020416788
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26303005
[Journal Article] 生合成遺伝子に秘められたホストへの気遣い2015
- Author(s)
  脇本敏幸, 江上蓉子, 阿部郁朗
- Journal Title
  
  KAGAKU TO SEIBUTSU
  
  Volume: 53 Issue: 8 Pages: 497-499
- DOI
  10.1271/kagakutoseibutsu.53.497
- NAID
  130005165653
- ISSN
  0453-073X, 1883-6852
- Language
  Japanese
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26303005
[Journal Article] Dietziamides, novel tetramic acid dimers from Dietzia timorensis MZ-3 with antioxidative activity2015
- Author(s)
  S. Hoshino, T. Wakimoto, H. Zhang, F. Hayashi, M. Okada, I. Abe
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 25 Issue: 18 Pages: 3953-3955
- DOI
  10.1016/j.bmcl.2015.07.035
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K12740, KAKENHI-PROJECT-15H03112, KAKENHI-PROJECT-24688011
[Journal Article] Revised structure of cyclolithistide A, a cyclic depsipeptide from the marine sponge Discodermia japonica2014
- Author(s)
  H. Tajima, T. Wakimoto, K. Takada, Y. Ise, I. Abe
- Journal Title
  
  J. Nat. Prod.
  
  Volume: 77 Issue: 1 Pages: 154-158
- DOI
  10.1021/np400668k
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25108705, KAKENHI-PROJECT-25560399, KAKENHI-PROJECT-25660163, KAKENHI-PROJECT-25712024, KAKENHI-PROJECT-26303005
[Journal Article] Lipodiscamides A-C, new cytotoxic lipopeptides from the marine sponge Discodermia kiiensis2014
- Author(s)
  K. C. Tan, T. Wakimoto, I. Abe
- Journal Title
  
  Org. Lett.
  
  Volume: 16 Issue: 12 Pages: 3256-3259
- DOI
  10.1021/ol501271v
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-25108705, KAKENHI-PROJECT-25560399, KAKENHI-PROJECT-26303005
[Journal Article] A methyltransferase initiates terpene cyclization in teleocidin B biosynthesis2014
- Author(s)
  Awakawa, T., Zhang, L., Wakimoto, T., Hoshino, S., Mori, T., Ito, T., Ishikawa, J., Tanner, M. E., Abe, I.
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 136 Issue: 28 Pages: 9910-9913
- DOI
  10.1021/ja505224r
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22108004, KAKENHI-PLANNED-22108010, KAKENHI-PROJECT-23241068, KAKENHI-PUBLICLY-25108705, KAKENHI-PROJECT-25560399, KAKENHI-PROJECT-25750382, KAKENHI-PROJECT-26460140
[Journal Article] Complete biosynthetic pathway of anditomin: nature's sophisticated synthetic route to a complex fungal meroterpenoid2014
- Author(s)
  Matsuda, Y., Wakimoto, T., Mori, T., Awakawa, T., Abe, I.
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 136 Issue: 43 Pages: 15326-15336
- DOI
  10.1021/ja508127q
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-22108004, KAKENHI-PROJECT-23241068, KAKENHI-PUBLICLY-25108705, KAKENHI-PROJECT-25560399, KAKENHI-PROJECT-26560428
[Journal Article] Phosphocalyculin C as a pyrophosphate protoxin of calyculin C in the marine sponge Discodermia calyx2014
- Author(s)
  Y. Egami, T. Wakimoto, I. Abe
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 24 Issue: 22 Pages: 5150-5153
- DOI
  10.1016/j.bmcl.2014.10.002
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-25108705, KAKENHI-PROJECT-25560399, KAKENHI-PROJECT-26303005
[Journal Article] Arcyriaflavin E, a new cytotoxic indolocarbazole alkaloid isolated by combined-culture of mycolic acid-containing bacteria and Streptomyces cinnamoneus NBRC 13823.2014
- Author(s)
  S. Hoshino, L. Zhang, T. Awakawa, T. Wakimoto, H. Onaka, I. Abe
- Journal Title
  
  J. Antibiot.
  
  Volume: 67 Issue: 5 Pages: 1-3
- DOI
  10.1038/ja.2014.147
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-25108705, KAKENHI-PROJECT-25292046, KAKENHI-PROJECT-25560399
[Journal Article] An environmental bacterial taxon with a large and distinct metabolic repertoire2014
- Author(s)
  Wilson, M. C., Mori, T., Ruckert, C., Uria, A. R., Helf, M. J., Takada, K., Gernert, C., Steffens, U. A. E., Heycke, N., Schmitt, S., Rinke, C., Helfrich, E. J. N., Brachmann, A. O., Gurgui, C., Wakimoto. T., Kracht, M., Crusemann, M., Hentschel, U., Abe, I., Matsunaga, S., Kalinowski, J., Takeyama, H., Piel, J.
- Journal Title
  
  Nature
  
  Volume: 506 Issue: 7486 Pages: 58-62
- DOI
  10.1038/nature12959
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22108004, KAKENHI-PROJECT-23241068, KAKENHI-PROJECT-24651239, KAKENHI-PUBLICLY-25108705, KAKENHI-PROJECT-25560399, KAKENHI-PROJECT-25660163, KAKENHI-PROJECT-25712024, KAKENHI-PROJECT-26303005
[Journal Article] Three acyltetronic acid derivatives: noncanonical cryptic polyketides from Aspergillus niger identified by genome mining2014
- Author(s)
  Yang, X.-L., Awakawa, T., Wakimoto, T., Abe, I.
- Journal Title
  
  ChemBioChem
  
  Volume: 15 Issue: 11 Pages: 1578-1583
- DOI
  10.1002/cbic.201402172
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23241068, KAKENHI-PUBLICLY-25108705, KAKENHI-PROJECT-25560399
[Journal Article] Enantioselective Synthesis of SB-2032072014
- Author(s)
  Yasuo Hirooka, Kazutada Ikeuchi, Yuichiro Kawamoto, Yusuke Akao, Takumi Furuta, Tomohiro Asakawa, Makoto Inai, Toshiyuki Wakimoto, Tohru Fukuyama and Toshiyuki Kan
- Journal Title
  
  Org. Lett.
  
  Volume: 16 Issue: 6 Pages: 1646-1646
- DOI
  10.1021/ol5002973
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390007, KAKENHI-PUBLICLY-25108705, KAKENHI-PROJECT-25560399, KAKENHI-PUBLICLY-26102736, KAKENHI-PROJECT-26460007
[Journal Article] Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont2014
- Author(s)
  Wakimoto, T., Egami, Y., Nakashima, Y., Wakimoto,Y., Mori, T., Awakawa,T., Ito, T., Kenmoku, H., Asakawa, Y., Piel, J., Abe, I.
- Journal Title
  
  Nature Chem. Biol.
  
  Volume: 10 Issue: 8 Pages: 648-655
- DOI
  10.1038/nchembio.1573
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22108004, KAKENHI-PROJECT-23241068, KAKENHI-PUBLICLY-25108705, KAKENHI-PROJECT-25303010, KAKENHI-PROJECT-25560399, KAKENHI-PROJECT-26303005, KAKENHI-PROJECT-26460140, KAKENHI-PROJECT-26560428
[Journal Article] Allos-hemicalyculin A, a photochemically converted calyculin from the marine sponge Discodermia calyx2013
- Author(s)
  M. Kimura, T. Wakimoto, I. Abe
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 54 Issue: 1 Pages: 114-116
- DOI
  10.1016/j.tetlet.2012.10.130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710250
[Journal Article] Epigenetic modifier-induced biosynthesis of novel fusaric acid derivatives in endophytic fungi from Datura stramonium L.2013
- Author(s)
  H.-J. Chen, T. Awakawa, J.-Y. Sun, T. Wakimoto, I. Abe
- Journal Title
  
  Nat. Prod. Bioprospect.
  
  Volume: 3 Pages: 20-23
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25108705
[Journal Article] Indole-porphyrin hybrids produced by metagenomics2013
- Author(s)
  Yang, X. -L., Wakimoto, T., Takeshige, Y., He, R., Egami, Y., Abe, I.
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 23 Issue: 13 Pages: 2810-2813
- DOI
  10.1016/j.bmcl.2013.04.076
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J10253, KAKENHI-PUBLICLY-25108705, KAKENHI-PROJECT-25560399
[Journal Article] Induced biosyntheses of a novel butyrophenone and two aromatic polyketides in the plant pathogen Stagonospora nodorum2013
- Author(s)
  X.-L. Yang, T. Awakawa, T. Wakimoto, I. Abe
- Journal Title
  
  Nat. Prod. Bioprospect.
  
  Volume: 3 Pages: 141-144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25560399
[Journal Article] Epigenetic modifier-induced biosynthesis of novel fusaric acid derivatives in endophytic fungi from Datura stramonium L.2013
- Author(s)
  H.-J. Chen, T. Awakawa, J.-Y. Sun, T. Wakimoto, I. Abe
- Journal Title
  
  Nat. Prod. Bioprospect.
  
  Volume: 3 Pages: 20-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25560399
[Journal Article] Pyranonigrin E : a novel PKS-NRPS hybrid metabolite from Aspergillus niger ide ntified by genome mining2013
- Author(s)
  Takayoshi Awakawa., Xiao-Long Xia o-Long Yang, Toshiyuki Wakimoto., Ikuro Abe
- Journal Title
  
  Chembiochem
  
  Volume: 14 Issue: 16 Pages: 2095-2099
- DOI
  10.1002/cbic.201300430
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12F02032, KAKENHI-PROJECT-23241068, KAKENHI-PUBLICLY-25108705, KAKENHI-PROJECT-25560399
[Journal Article] Spiro-ring formation is catalyzed by a multifunctional dioxygenase in austinol biosynthesis2013
- Author(s)
  Y. Matsuda, T. Awakawa, T. Wakimoto, and I. Abe
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 135 Issue: 30 Pages: 10962-10965
- DOI
  10.1021/ja405518u
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22108001, KAKENHI-PLANNED-22108004, KAKENHI-PROJECT-23241068, KAKENHI-PUBLICLY-25108705, KAKENHI-PROJECT-25560399
[Journal Article] Induced production of novel prenyldepside and coumarins in endophytic fungi Pestalotiopsis acaciae2013
- Author(s)
  X.-L. Yang, T. Awakawa, T. Wakimoto, I. Abe
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 54 Pages: 5814-5817
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25560399
[Journal Article] Induced biosyntheses of a novel butyrophenone and two aromatic polyketides in the plant pathogen Stagonospora nodorum2013
- Author(s)
  X.-L. Yang, T. Awakawa, T. Wakimoto, I. Abe
- Journal Title
  
  Nat. Prod. Bioprospect.
  
  Volume: 3 Pages: 141-144
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25108705
[Journal Article] Induced production of the novel glycolipid ustilagic acid C in the plant pathogen Ustilago maydis2013
- Author(s)
  X.-L. Yang, T. Awakawa, T. Wakimoto, I. Abe
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 54 Pages: 3655-3657
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25108705
[Journal Article] Induced production of novel prenyldepside and coumarins in endophytic fungi Pestalotiopsis acaciae2013
- Author(s)
  X.-L. Yang, T. Awakawa, T. Wakimoto, I. Abe
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 54 Pages: 5814-5817
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25108705
[Journal Article] Cycloforskamide, a cytotoxic macrocyclic peptide from the sea slug Pleurobranchus forskalii2013
- Author(s)
  K. C. Tan, T. Wakimoto, K. Takada, T. Ohtsuki, N. Uchiyama, Y. Goda, I. Abe
- Journal Title
  
  J. Nat. Prod.
  
  Volume: 76 Issue: 7 Pages: 1388-1391
- DOI
  10.1021/np400404r
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25560399, KAKENHI-PROJECT-25660163, KAKENHI-PROJECT-25712024
[Journal Article] Induced production of the novel glycolipid ustilagic acid C in the plant pathogen Ustilago maydis2013
- Author(s)
  X.-L. Yang, T. Awakawa, T. Wakimoto, I. Abe
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 54 Pages: 3655-3657
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25560399
[Journal Article] Cycloforskamide, a cytotoxic macrocyclic peptide from the sea slug Pleurobranchus forskalii2013
- Author(s)
  K. C. Tan, T. Wakimoto, K. Takada, T. Ohtsuki, N. Uchiyama, Y. Goda, I. Abe
- Journal Title
  
  Toxicon
  
  Volume: 72 Pages: 1-4
- DOI
  10.1016/j.toxicon.2013.05.021
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25108705, KAKENHI-PROJECT-25560399
[Journal Article] Labile natural products.2012
- Author(s)
  T. Wakimoto, I. Abe
- Journal Title
  
  MedChemComm
  
  Volume: 3 Issue: 8 Pages: 866-870
- DOI
  10.1039/c2md20016c
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710250
[Journal Article] Heterologously expressed β-hydroxyl fatty acids from a metagenomic library of a marine sponge2012
- Author(s)
  R. He, T. Wakimoto, Y. Egami, H. Kenmoku, T. Ito, Y. Asakawa, I. Abe
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 22 Issue: 24 Pages: 7322-7325
- DOI
  10.1016/j.bmcl.2012.10.082
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710250, KAKENHI-PROJECT-24651247, KAKENHI-PROJECT-24710253
[Journal Article] Engineering of plant type III polyketide synthases.2012
- Author(s)
  T. Wakimoto, H. Morita, I. Abe
- Journal Title
  
  Methods in Enzymology
  
  Volume: 515 Pages: 337-358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710250
[Journal Article] Porphyrins from a metagenomic library of the marine sponge Discodermia calyx2012
- Author(s)
  He, R.
- Journal Title
  
  Mol. BioSyst.
  
  Volume: 6 Issue: 9 Pages: 2334-2338
- DOI
  10.1039/c2mb25169h
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23241068, KAKENHI-PROJECT-23710250, KAKENHI-PROJECT-24651247, KAKENHI-PROJECT-24710253
[Journal Article] Engineering of plant type III polyketide synthases2012
- Author(s)
  Wakimoto, I.
- Journal Title
  
  Methods in Enzymology
  
  Volume: 51 Pages: 337-358
- DOI
  10.1016/b978-0-12-394290-6.00016-1
- ISBN
  9780123942906
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23241068, KAKENHI-PLANNED-22108004
[Journal Article] Calyxamides A and B, cytotoxic cyclic peptides from the marine sponge Discodermia calyx2012
- Author(s)
  M. Kimura, T. Wakimoto, Y. Egami, K. C. Tan, Y. Ise, I. Abe
- Journal Title
  
  J. Nat. Prod.
  
  Volume: 75 Issue: 2 Pages: 290-294
- DOI
  10.1021/np2009187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710250
[Journal Article] Enantioselective Total Synthesis of Aperidine2011
- Author(s)
  Toshiyuki Wakimoto, Kakeru Miyata, Hitoshi Ouchi, Tomohiro Asakawa, Haruo Nukaya, Yoshihide Suwa and Toshiyuki Kan
- Journal Title
  
  Organic Letters
  
  Volume: 13 Issue: 10 Pages: 2789-2791
- DOI
  10.1021/ol200728w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710250
[Journal Article] Cytotoxic tetramic acid derivative produced by a plant type III polyketide synthase2011
- Author(s)
  Wakimoto, T., Mori, T., Morita, H., Abe, I.
- Journal Title
  
  J.Am.Chem.Soc.
  
  Volume: 133 Issue: 13 Pages: 4746-4749
- DOI
  10.1021/ja2006737
- NAID
  10029237041
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22108004, KAKENHI-PROJECT-23241068
[Journal Article] Furan fatty acid as an anti-inflammatory component from green-lipped mussel Perna canaliculus2011
- Author(s)
  Wakimoto, T., Kondo, H., Nii, H., Kimura, K., Egami, Y., Oka, Y., Yoshida, M., Kida, E., Ye, Y.-p., Akahoshi, S., Asakawa, T., Matsumura, K., Ishida, H., Nukaya, H., Tsuji, K., Kan, T., Abe, I.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA
  
  Volume: 108 Issue: 42 Pages: 17533-17537
- DOI
  10.1073/pnas.1110577108
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22108004, KAKENHI-PROJECT-23241068, KAKENHI-PROJECT-23710250
[Journal Article] Cytotoxic Tetramic Acid Derivative Produced by a Plant Type-III Polyketide Synthase2011
- Author(s)
  T.Wakimoto, T.Mori, H.Morita, I.Abe
- Journal Title
  
  J.Am.Chem.Soc.
  
  Volume: 133(In press(掲載確定))
- NAID
  10029237041
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22108004
[Journal Article] Synthesis of unnatural alkaloid scaffolds by exploiting plant polyketide synthase2011
- Author(s)
  Morita, H., Yamashita, M., Shi, S.-P., Wakimoto, T., Kondo, S., Kato, R., Sugio, S., Kohno, T., Abe, I.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA
  
  Volume: 108 Issue: 33 Pages: 13504-13509
- DOI
  10.1073/pnas.1107782108
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22108001, KAKENHI-PLANNED-22108004, KAKENHI-PROJECT-23241068, KAKENHI-PROJECT-23710250
[Journal Article] Binding affinity of tea catechins for human serum albumin: characterization by high-performance affinity chromatography with immobilized albmin column.2010
- Author(s)
  T. Ishii, K. Minoda, M. -J. Bae, T. Mori, Y. Uekusa, T. Ichikawa, Y. Aihara, T. Furuta, T. Wakimoto, T. Kan, T. Nakayama
- Journal Title
  
  Mol. Nutr. Food Res. 54
  
  Pages: 1-7
- Data Source
  KAKENHI-PROJECT-19780162
[Journal Article] Modified Julia-Kocienski reaction promoted by means of m-NPT (Nitrophenyltetrazole) sulfone.2010
- Author(s)
  Y. Sakai, K. Ikeuchi, Y. Yamada, T. Wakimoto, T. Kan
- Journal Title
  
  Synlett 20
  
  Pages: 827-829
- Data Source
  KAKENHI-PROJECT-19780162
[Journal Article] Solid support synthesis of artificial phospholipids.2009
- Author(s)
  T. Furuta, H. Onuki, M. Mochizuki, M. Ito, M. Inai, T. Wakimoto, T. Kan
- Journal Title
  
  Synlett
  
  Pages: 3373-3377
- Data Source
  KAKENHI-PROJECT-19780162
[Journal Article] Concise synthesis of chafuroside A and B.2009
- Author(s)
  T.Furuta, M.Nakayama, H.Suzuki, H.Tajimi, M.Inai, H.Nukaya, T.Wakimoto, T.Kan
- Journal Title
  
  Org.Lett. 11
  
  Pages: 2233-2236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19780162
[Journal Article] Regioselective synthesis of methylated epigallocatechin gallate via nitrobe nxenesulfony1 (Ns) progectiong group.2009
- Author(s)
  Y.Aihara, A.Yoshida, T.Furuta, T.Wakimoto, T.Akizawa, M.Konishi, T.Kan
- Journal Title
  
  Bioorg.Med.Chem.Lett. 19
  
  Pages: 4171-4174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19780162
[Journal Article] Quantitation of chafuroside A and B in tea leaves and isolation of prechafuroside A and B from oolong tea leaves.2009
- Author(s)
  H. Ishida, T. Wakimoto, Y. Kitao, S. Tanaka, T. Miyase, H. Nuakaya
- Journal Title
  
  J. Agric. Food. Chem. 57
  
  Pages: 6779-6786
- Data Source
  KAKENHI-PROJECT-19780162
[Journal Article] Structure-activity relationship study on α 1 adrenergic receptor antangonists from beer.2009
- Author(s)
  T.Wakimoto, M.Nitta, T.Chiba, Y.Yiping, K.Tsuji, T.Kan, H.Nukaya, M.Ishiguro, M.Koike, Y.Yokoo, Y.Suwa
- Journal Title
  
  Bioorg.Med.Chem.Lett. 19
  
  Pages: 5905-5908
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19780162
[Journal Article] Solid support synthesis of artificial phospholipids.2009
- Author(s)
  T.Furuta, H.Onuki, M.Mochizuki, M.Ito, M.Inai, T.Wakimoto, T.Kan
- Journal Title
  
  Synlett
  
  Pages: 3373-3377
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19780162
[Journal Article] Concise synthesis of chafuroside A and B.2009
- Author(s)
  T. Furuta, M. Nakayama, H. Suzuki, H. Tajimi, M. Inai, H. Nukaya, T. Wakimoto, T. Kan
- Journal Title
  
  Org. Lett. 11
  
  Pages: 2233-2236
- Data Source
  KAKENHI-PROJECT-19780162
[Journal Article] Quantitation of chafuroside A and B in tea leaves and isolation of prechafuroside A and B from oolong tea leaves.2009
- Author(s)
  H.Ishida, T.Wakimoto, Y.Kitao, S.Tanaka, T.Miyase, H.Nuakaya
- Journal Title
  
  J.Agric.Food.Chem. 57
  
  Pages: 6779-6786
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19780162
[Journal Article] Structure-activity relationship study onα1 adrenergic receptor antagonists from beer.2009
- Author(s)
  T. Wakimoto, M. Nitta, T. Chiba, Y. Yiping, K. Tsuji, T. Kan, H. Nukaya, M. Ishiguro, M. Koike, Y. Yokoo, Y. Suwa
- Journal Title
  
  Bioorg. Med. Chem. Lett. 19
  
  Pages: 5905-5908
- Data Source
  KAKENHI-PROJECT-19780162
[Journal Article] Regioselective synthesis of methylated epigallocatechin gallate via nitrobenxenesulfonyl (Ns) protectiong group.2009
- Author(s)
  Y. Aihara, A. Yoshida, T. Furuta, T. Wakimoto, T. Akizawa, M. Konishi, T. Kan
- Journal Title
  
  Bioorg. Med. Chem. Lett. 19
  
  Pages: 4171-4174
- Data Source
  KAKENHI-PROJECT-19780162
[Journal Article] Total synthesis of (-)-Serotobenine.2008
- Author(s)
  Y. Koizumi, H. Kobayashi, T. Wakimoto, T. Furuta, T. Fukuyama, T. Kan
- Journal Title
  
  J. Am. Chem. Soc. 130
  
  Pages: 16854-16855
- Data Source
  KAKENHI-PROJECT-19780162
[Journal Article] Total Synthesis of(-)-Serotobenine2008
- Author(s)
  Koizumi, Y. ; Kobayashi, H. ; Wakimoto, T. ; Furuta, T. ; Fukuyama, T. ; Kan, T.
- Journal Title
  
  J. Am. Chem. Soc 130
  
  Pages: 16854-16855
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19780162
[Journal Article] Stereocontrolled total synthesis of (-)-myriocin.2008
- Author(s)
  M. Inai, T. Goto, T. Furuta, T. Wakimoto, T. Kan
- Journal Title
  
  Tetrahedron: Asymmetry 19
  
  Pages: 2771-2773
- Data Source
  KAKENHI-PROJECT-19780162
[Journal Article] Structural Determination of Two Active Compounds Bind to the Muscarinic M3 receptor in Beer.2007
- Author(s)
  N. Yamaji, Y. Yokoo, T. Iwashita, A. Nemoto, M. Koike, Y. Suwa, H. Masuya, T. Wakimoto, K. Tsuji, H. Nukaya
- Journal Title
  
  Alcohol Clin. Exp. Res. 31
- Data Source
  KAKENHI-PROJECT-19780162
[Patent] 環状ペプチドの効率的な化学－酵素合成方法2022
- Inventor(s)
  脇本敏幸、松田研一、小林雅和
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Data Source
  KAKENHI-PLANNED-22H05128
[Patent] 新規プレニル化酵素2021
- Inventor(s)
  脇本敏幸、沖野龍文、松田研一、パンチンスン
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-21H02635
[Patent] 環状ペプチドの効率的な化学－酵素合成方法2021
- Inventor(s)
  脇本敏幸、松田研一、小林雅和
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-170218
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-21H02635
[Patent] 化合物、その製造方法、抗菌剤及び銅キレート剤医薬2021
- Inventor(s)
  高田雅親、砂原博文、脇本敏幸、松田研一
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-109058
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-21H02635
[Patent] 銅キレート剤、抗がん剤及びウィルソン病の予防又は治療剤2021
- Inventor(s)
  高田雅親、砂原博文、脇本敏幸、松田研一
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-050797
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-21H02635
[Patent] 酵素を用いたペプチドライゲーション2021
- Inventor(s)
  脇本敏幸、松田研一、小林雅和
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-157054
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-21H02635
[Patent] ペプチド類の大環状化酵素2019
- Inventor(s)
  脇本敏幸、倉永健史、松田研一
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-18H02581
[Patent] ペプチド類の大環状化酵素2019
- Inventor(s)
  脇本敏幸、倉永健史、松田研一
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PLANNED-16H06448
[Patent] ペプチド類の大環状化酵素2018
- Inventor(s)
  脇本敏幸、倉永健史、松田研一
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-050797
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-17F17114
[Patent] ペプチド類の大環状化酵素2018
- Inventor(s)
  脇本敏幸、倉永健史、松田研一
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-050797
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PLANNED-16H06448
[Patent] ペプチド類の大環状化酵素2018
- Inventor(s)
  脇本敏幸、倉永健史、松田研一
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-050797
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-18H02581
[Patent] 植物ポリケタイド合成酵素を用いた3環性非天然型アルカロイドの生産2010
- Inventor(s)
  阿部郁朗、脇本敏幸、森田洋行、山下誠
- Industrial Property Rights Holder
  東京大学
- Industrial Property Number
  2010-212208
- Filing Date
  2010-09-22
- Data Source
  KAKENHI-PLANNED-22108004
[Patent] 高脂血症処置剤2007
- Inventor(s)
  脇本敏幸
- Industrial Property Rights Holder
  辻邦郎
- Filing Date
  2007-08-20
- Data Source
  KAKENHI-PROJECT-19780162
[Patent] 自己免疫疾患処置剤2007
- Inventor(s)
  脇本敏幸
- Industrial Property Rights Holder
  辻邦郎
- Filing Date
  2007-08-20
- Data Source
  KAKENHI-PROJECT-19780162
[Patent] 自己免疫疾患処置剤2007
- Inventor(s)
  脇本敏幸
- Industrial Property Rights Holder
  辻邦郎
- Filing Date
  2007-08-20
- Data Source
  KAKENHI-PROJECT-19780162
[Patent] フラン脂肪酸乃至はその誘導体を含有する皮膚外用剤2007
- Inventor(s)
  脇本敏幸
- Industrial Property Rights Holder
  辻邦郎
- Filing Date
  2007-08-20
- Data Source
  KAKENHI-PROJECT-19780162
[Patent] フラン脂肪酸乃至はその誘導体を含有する皮膚外用剤2007
- Inventor(s)
  脇本敏幸
- Industrial Property Rights Holder
  辻邦郎
- Filing Date
  2007-08-20
- Data Source
  KAKENHI-PROJECT-19780162
[Patent] 高脂血症処置剤2007
- Inventor(s)
  脇本敏幸
- Industrial Property Rights Holder
  辻邦郎
- Filing Date
  2007-08-20
- Data Source
  KAKENHI-PROJECT-19780162
[Presentation] 新規ペプチド修飾酵素の機能拡張による大環状複雑骨格の創成2024
- Author(s)
  脇本敏幸
- Organizer
  「予知生合成科学」第３回公開シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-23KF0001
[Presentation] 新規ペプチド修飾酵素の機能拡張による大環状複雑骨格の創成2024
- Author(s)
  脇本敏幸
- Organizer
  「予知生合成科学」第３回公開シンポジウム
- Data Source
  KAKENHI-PLANNED-22H05128
[Presentation] 新規ペプチド修飾酵素の機能拡張による大環状複雑骨格の創成2024
- Author(s)
  脇本敏幸
- Organizer
  「予知生合成科学」第３回公開シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-21H02635
[Presentation] Biosynthesis of cytotoxic natural products from marine sponges2023
- Author(s)
  脇本敏幸
- Organizer
  日本薬学会第143年会
- Invited
- Data Source
  KAKENHI-PLANNED-22H05128
[Presentation] "求愛・交尾時期以外でもクリガニのメス尿中に性フェロモンが含まれる可能性について"2023
- Author(s)
  "神尾道也・七條琳太郎・家後勇樹・永井宏史（海洋大）・脇本敏幸・和田哲・山家秀信."
- Organizer
  日本甲殻類学会第 61 回大会（東京）
- Data Source
  KAKENHI-PROJECT-23K27002
[Presentation] クリガニTelmessus cheiragonus抱卵メス尿のフェロモン活性2023
- Author(s)
  神尾道也、七條琳太郎、家後勇樹、永井宏史、脇本敏幸、和田　哲、山家秀信
- Organizer
  第15回化学生態学研究会(函館市)
- Data Source
  KAKENHI-PROJECT-23K27002
[Presentation] 新規ペプチド修飾酵素の機能拡張による大環状複雑骨格の創成2023
- Author(s)
  脇本敏幸
- Organizer
  「予知生合成科学」第１回公開シンポジウム
- Data Source
  KAKENHI-PLANNED-22H05128
[Presentation] Chemoenzymatic synthesis of cyclic peptides by non-ribosomal peptide cyclase2023
- Author(s)
  脇本敏幸
- Organizer
  日本薬学会第143年会
- Invited
- Data Source
  KAKENHI-PLANNED-22H05128
[Presentation] Biosynthetic Enzymes Modify Ribosomal and Non-ribosomal Peptides2021
- Author(s)
  Toshiyuki Wakimoto
- Organizer
  International Summer Course on Marine Natural Products
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02635
[Presentation] A New Cyclase Family Catalyzing Head-to-tail Macrolactamization of Non-ribosomal Peptides2021
- Author(s)
  Toshiyuki Wakimoto
- Organizer
  Marine Ecosystem, Cradle of Biological Diversity, Natural Chemicals and Lead Pharmaceuticals
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02635
[Presentation] Insights into Phosphatase-activated Chemical Defense in a Marine Sponge Holobiont2021
- Author(s)
  Toshiyuki Wakimoto
- Organizer
  Pacifichem2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02635
[Presentation] Marine Natural Product Biosynthesis2021
- Author(s)
  Toshiyuki Wakimoto
- Organizer
  International Virtual Course Marine Natural Product
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02635
[Presentation] Discovery and functional analysis of a new peptide cyclase, PBP-type TE2021
- Author(s)
  Wakimoto Toshiyuki
- Organizer
  1st GSD/GI-CoRE国際シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06448
[Presentation] Discovery and functional analysis of a new peptide cyclase, PBP-type TE2021
- Author(s)
  Wakimoto Toshiyuki
- Organizer
  1st GSD/GI-CoRE国際シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02581
[Presentation] 新規ペプチド環化酵素PBP-type TEの機能解析2021
- Author(s)
  脇本敏幸
- Organizer
  日本農芸化学会2021大会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02581
[Presentation] 海洋生物活性天然物の生合成に関する研究2021
- Author(s)
  脇本敏幸
- Organizer
  日本薬学会第141年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02581
[Presentation] Insights into Phosphatase-activated Chemical Defense in a Marine Sponge Holobiont2021
- Author(s)
  Toshiyuki Wakimoto
- Organizer
  Chemical Biology Luncheon Seminar
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02635
[Presentation] 海洋生物活性天然物の生合成に関する研究2021
- Author(s)
  脇本敏幸
- Organizer
  日本薬学会第141年会
- Invited
- Data Source
  KAKENHI-PLANNED-16H06448
[Presentation] 新規ペプチド環化酵素PBP-type TEの機能解析2021
- Author(s)
  脇本敏幸
- Organizer
  日本農芸化学会2021大会
- Invited
- Data Source
  KAKENHI-PLANNED-16H06448
[Presentation] カリクリン生合成過程に内在する活性制御機構2020
- Author(s)
  脇本敏幸
- Organizer
  日本農芸化学会2020年度大会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02581
[Presentation] A new off-loading cyclase in non-ribosomal peptide biosynthesis2020
- Author(s)
  Wakimoto Toshiyuki
- Organizer
  3rd International Conference on Natural Product Discovery and Development in the Genomic Era
- Invited
- Data Source
  KAKENHI-PLANNED-16H06448
[Presentation] カリクリン生合成過程に内在する活性制御機構2020
- Author(s)
  脇本敏幸
- Organizer
  日本農芸化学会2020年度大会
- Invited
- Data Source
  KAKENHI-PLANNED-16H06448
[Presentation] A new off-loading cyclase in non-ribosomal peptide biosynthesis2020
- Author(s)
  Wakimoto Toshiyuki
- Organizer
  3rd International Conference on Natural Product Discovery and Development in the Genomic Era
- Invited
- Data Source
  KAKENHI-PROJECT-18H02581
[Presentation] Chemical defense mechanism in a Japanese marine sponge, Discodermia calyx2019
- Author(s)
  Wakimoto Toshiyuki
- Organizer
  Blue Pharmacy: from Sources to Clinical Reality
- Invited
- Data Source
  KAKENHI-PLANNED-16H06448
[Presentation] 難培養微生物を起源とする希少医薬品資源の量産2019
- Author(s)
  脇本敏幸
- Organizer
  生物合成系の再設計による複雑骨格機能分子の革新的創成科学、第６回公開シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-16H06448
[Presentation] 難培養微生物を起源とする希少医薬品資源の量産2019
- Author(s)
  脇本敏幸
- Organizer
  生物合成系の再設計による複雑骨格機能分子の革新的創成科学、第6回公開シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18H02581
[Presentation] Chemical defense mechanism in a Japanese marine sponge, Discodermia calyx2019
- Author(s)
  Wakimoto Toshiyuki
- Organizer
  Blue Pharmacy: from Sources to Clinical Reality
- Invited
- Data Source
  KAKENHI-PROJECT-18H02581
[Presentation] 非リボソームペプチド新規環化酵素の発見2019
- Author(s)
  脇本敏幸
- Organizer
  第51回若手ペプチド夏の勉強会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02581
[Presentation] 非リボソームペプチド新規環化酵素の発見2019
- Author(s)
  脇本敏幸
- Organizer
  第51回若手ペプチド夏の勉強会
- Invited
- Data Source
  KAKENHI-PLANNED-16H06448
[Presentation] メタゲノムマイニングによる海綿由来新規天然物の探索2018
- Author(s)
  脇本敏幸
- Organizer
  日本薬学会第138会
- Invited
- Data Source
  KAKENHI-PROJECT-15H03112
[Presentation] Unusual Processes of PKS and NRPS Assembly Lines in Marine Bacteria2018
- Author(s)
  Toshiyuki Wakimoto
- Organizer
  1st German-Japanese Joint Symposium on the Biosynthesis of Natural Products
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06448
[Presentation] 難培養微生物を起源とする希少医薬品資源の量産2018
- Author(s)
  脇本敏幸
- Organizer
  生物合成系の再設計による複雑骨格機能分子の革新的創成科学、第２回公開シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17F17114
[Presentation] 生合成遺伝子から見出した新規天然物と難培養微生物2018
- Author(s)
  脇本敏幸
- Organizer
  新化学技術推進協会ライフサイエンス技術部会講演会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02581
[Presentation] 難培養微生物を起源とする希少医薬品資源の量産2018
- Author(s)
  脇本敏幸
- Organizer
  生物合成系の再設計による複雑骨格機能分子の革新的創成科学、第2回公開シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18H02581
[Presentation] Unusual Processes of PKS and NRPS Assembly Lines in Marine Bacteria2018
- Author(s)
  Toshiyuki Wakimoto
- Organizer
  1st German-Japanese Joint Symposium on the Biosynthesis of Natural Products
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02581
[Presentation] 難培養微生物を起源とする希少医薬品資源の量産2018
- Author(s)
  脇本敏幸
- Organizer
  生物合成系の再設計による複雑骨格機能分子の革新的創成科学、第2回公開シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-16H06448
[Presentation] Investigating spongistatin biosynthesis in complex sponge-bacteria association2018
- Author(s)
  Agustinus R. Uria, Kenichi Matsuda, Toshiyuki Wakimoto
- Organizer
  3rd International Symposium on Sponge Microbiology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17F17114
[Presentation] Marine Sponge-derived Metagenomes/uncultured Bacteria - a Rich Source of Novel Natural Product Biosynthetic Genes2018
- Author(s)
  Toshiyuki Wakimoto
- Organizer
  International Seminar on Natural Products Medicines 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02581
[Presentation] A new off-loading enzyme in non-ribosomal peptide biosynthesis2018
- Author(s)
  Toshiyuki Wakimoto
- Organizer
  2nd China-Japan Joint Symposium on Natural Product Biosynthesis
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06448
[Presentation] 生合成遺伝子から見出した新規天然物と難培養微生物2018
- Author(s)
  脇本敏幸
- Organizer
  新化学技術推進協会ライフサイエンス技術部会講演会
- Invited
- Data Source
  KAKENHI-PROJECT-17F17114
[Presentation] メタゲノムマイニングによる海綿由来新規天然物の探索2018
- Author(s)
  脇本敏幸
- Organizer
  日本薬学会第138会
- Invited
- Data Source
  KAKENHI-PLANNED-16H06448
[Presentation] A new off-loading enzyme in non-ribosomal peptide biosynthesis2018
- Author(s)
  Toshiyuki Wakimoto
- Organizer
  2nd China-Japan Joint Symposium on Natural Product Biosynthesis
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17F17114
[Presentation] Marine Sponge-derived Metagenomes/uncultured Bacteria - a Rich Source of Novel Natural Product Biosynthetic Genes2018
- Author(s)
  Toshiyuki Wakimoto
- Organizer
  International Seminar on Natural Products Medicines 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06448
[Presentation] Unusual Processes of PKS and NRPS Assembly Lines in Marine Bacteria2018
- Author(s)
  Toshiyuki Wakimoto
- Organizer
  1st German-Japanese Joint Symposium on the Biosynthesis of Natural Products
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17F17114
[Presentation] 生合成遺伝子から見出した新規天然物と難培養微生物2018
- Author(s)
  脇本敏幸
- Organizer
  新化学技術推進協会ライフサイエンス技術部会講演会
- Invited
- Data Source
  KAKENHI-PLANNED-16H06448
[Presentation] メタゲノムマイニングによる海綿由来新規天然物の探索2018
- Author(s)
  脇本敏幸
- Organizer
  日本薬学会第138会
- Invited
- Data Source
  KAKENHI-PROJECT-17F17114
[Presentation] Marine Sponge-derived Metagenomes/uncultured Bacteria - a Rich Source of Novel Natural Product Biosynthetic Genes2018
- Author(s)
  Toshiyuki Wakimoto
- Organizer
  International Seminar on Natural Products Medicines 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17F17114
[Presentation] A new off-loading enzyme in non-ribosomal peptide biosynthesis2018
- Author(s)
  Toshiyuki Wakimoto
- Organizer
  2nd China-Japan Joint Symposium on Natural Product Biosynthesis
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02581
[Presentation] メタゲノムマイニングによる海綿由来新規天然物の探索2017
- Author(s)
  脇本敏幸
- Organizer
  理研シンポジウム、高磁場・高感度NMR利活用促進のための天然物分野における日中連携シンポジウム2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03112
[Presentation] Marine sponge-derived metagenomes/uncultured bacteria - a rich source of novel natural product biosynthetic genes2017
- Author(s)
  Wakimoto Toshiyuki
- Organizer
  1st China-Japan Joint Symposium on Natural Product Biosynthesis, Shanghai, China
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17F17114
[Presentation] Toward the dark matter of marine natural products2017
- Author(s)
  Toshiyuki Wakimoto
- Organizer
  International Symposium on Marine Natural Products
- Place of Presentation
  Seoul, Korea
- Year and Date
  2017-02-28
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06448
[Presentation] Marine sponge-derived metagenomes/uncultured bacteria - a rich source of novel natural product biosynthetic genes2017
- Author(s)
  Wakimoto Toshiyuki
- Organizer
  1st China-Japan Joint Symposium on Natural Product Biosynthesis, Shanghai, China
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03112
[Presentation] Marine sponge-derived metagenomes/uncultured bacteria - a rich source of novel natural product biosynthetic genes2017
- Author(s)
  Wakimoto Toshiyuki
- Organizer
  International Conference on Marine Biodiversity and Biotechnology, Jakarta, Indonesia
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17F17114
[Presentation] Marine sponge-derived metagenomes/uncultured bacteria - a rich source of novel natural product biosynthetic genes2017
- Author(s)
  Wakimoto Toshiyuki
- Organizer
  Jinan University, College of Pharmacy, China
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06448
[Presentation] Marine sponge-derived metagenomes/uncultured bacteria - a rich source of novel natural product biosynthetic genes2017
- Author(s)
  Wakimoto Toshiyuki
- Organizer
  Jinan University, College of Pharmacy, China
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03112
[Presentation] Marine sponge-derived metagenomes/uncultured bacteria - a rich source of novel natural product biosynthetic genes2017
- Author(s)
  Wakimoto Toshiyuki
- Organizer
  South China Sea Institute of Oceanology, Chinese Academy of Sciences, China
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03112
[Presentation] Marine sponge-derived metagenomes/uncultured bacteria - a rich source of novel natural product biosynthetic genes2017
- Author(s)
  Wakimoto Toshiyuki
- Organizer
  South China Sea Institute of Oceanology, Chinese Academy of Sciences, China
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06448
[Presentation] Activated Chemical Defense of Japanese Marine Sponge Discodermia calyx2017
- Author(s)
  Wakimoto Toshiyuki
- Organizer
  ISCE/APACE, Kyoto, Japan
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06448
[Presentation] Marine sponge-derived metagenomes/uncultured bacteria - a rich source of novel natural product biosynthetic genes2017
- Author(s)
  Wakimoto Toshiyuki
- Organizer
  South China Sea Institute of Oceanology, Chinese Academy of Sciences, China
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17F17114
[Presentation] Marine sponge-derived metagenomes/uncultured bacteria - a rich source of novel natural product biosynthetic genes2017
- Author(s)
  Wakimoto Toshiyuki
- Organizer
  9th US-Japan Seminar on Natural Product Biosynthesis, UCLA Lake Arrowhead Conference Center, California, USA
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06448
[Presentation] Marine sponge-derived metagenomes/uncultured bacteria - a rich source of novel natural product biosynthetic genes2017
- Author(s)
  Toshiyuki Wakimoto
- Organizer
  International Conference on Marine Biodiversity and Biotechnology (Jakarta, Indonesia)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26303005
[Presentation] Marine sponge-derived metagenomes/uncultured bacteria - a rich source of novel natural product biosynthetic genes2017
- Author(s)
  Wakimoto Toshiyuki
- Organizer
  9th US-Japan Seminar on Natural Product Biosynthesis, UCLA Lake Arrowhead Conference Center, California, USA
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17F17114
[Presentation] Marine sponge-derived metagenomes/uncultured bacteria - a rich source of novel natural product biosynthetic genes2017
- Author(s)
  Wakimoto Toshiyuki
- Organizer
  9th US-Japan Seminar on Natural Product Biosynthesis, UCLA Lake Arrowhead Conference Center, California, USA
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03112
[Presentation] Activated Chemical Defense of Japanese Marine Sponge Discodermia calyx2017
- Author(s)
  Wakimoto Toshiyuki
- Organizer
  ISCE/APACE, Kyoto, Japan
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17F17114
[Presentation] Toward the dark matter of marine natural products2017
- Author(s)
  Toshiyuki Wakimoto
- Organizer
  International Symposium on Marine Natural Products
- Place of Presentation
  Seoul, Korea
- Year and Date
  2017-02-28
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12740
[Presentation] Activated Chemical Defense of Japanese Marine Sponge Discodermia calyx2017
- Author(s)
  Toshiyuki Wakimoto
- Organizer
  2017 ISCE/APACE (Kyoto, Japan)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26303005
[Presentation] Activated Chemical Defense of a Sponge-microbe Association2017
- Author(s)
  Toshiyuki Wakimoto
- Organizer
  University of Yangon (Yangon, Myanmar)
- Invited
- Data Source
  KAKENHI-PROJECT-26303005
[Presentation] Marine sponge-derived metagenomes/uncultured bacteria - a rich source of novel natural product biosynthetic genes2017
- Author(s)
  Wakimoto Toshiyuki
- Organizer
  International Conference on Marine Biodiversity and Biotechnology, Jakarta, Indonesia
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06448
[Presentation] Toward the dark matter of marine natural products2017
- Author(s)
  Toshiyuki Wakimoto
- Organizer
  International Symposium on Marine Natural Products
- Place of Presentation
  Seoul, Korea
- Year and Date
  2017-02-28
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03112
[Presentation] Marine sponge-derived metagenomes/uncultured bacteria - a rich source of novel natural product biosynthetic genes2017
- Author(s)
  Wakimoto Toshiyuki
- Organizer
  Jinan University, College of Pharmacy, China
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17F17114
[Presentation] Marine sponge-derived metagenomes/uncultured bacteria - a rich source of novel natural product biosynthetic genes2017
- Author(s)
  Wakimoto Toshiyuki
- Organizer
  1st China-Japan Joint Symposium on Natural Product Biosynthesis, Shanghai, China
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06448
[Presentation] メタゲノムマイニングによる海綿由来新規天然物の探索2017
- Author(s)
  脇本敏幸
- Organizer
  理研シンポジウム、高磁場・高感度NMR利活用促進のための天然物分野における日中連携シンポジウム2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06448
[Presentation] Activated Chemical Defense of Japanese Marine Sponge Discodermia calyx2017
- Author(s)
  Wakimoto Toshiyuki
- Organizer
  ISCE/APACE, Kyoto, Japan
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03112
[Presentation] メタゲノムマイニングによる海綿由来新規天然物の探索2017
- Author(s)
  脇本敏幸
- Organizer
  理研シンポジウム、高磁場・高感度NMR利活用促進のための天然物分野における日中連携シンポジウム2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17F17114
[Presentation] メタゲノムマイニングによる海綿由来新規天然物の探索2017
- Author(s)
  脇本敏幸
- Organizer
  理研シンポジウム、高磁場・高感度NMR利活用促進のための天然物分野における日中連携シンポジウム2017
- Invited
- Data Source
  KAKENHI-PROJECT-26303005
[Presentation] Marine sponge-derived metagenomes/uncultured bacteria - a rich source of novel natural product biosynthetic genes2017
- Author(s)
  Wakimoto Toshiyuki
- Organizer
  International Conference on Marine Biodiversity and Biotechnology, Jakarta, Indonesia
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03112
[Presentation] A Bacterial Symbiont in Japanese Marine Sponges Produces Biologically Active Metabolites2016
- Author(s)
  T. Wakimoto
- Organizer
  The 4th Frontier Chemistry Center International Symposium
- Place of Presentation
  北海道大学（北海道札幌市）
- Year and Date
  2016-02-23
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12740
[Presentation] Activated Chemical Defense of a Sponge-Microbe Association2016
- Author(s)
  T. Wakimoto
- Organizer
  Gordon Research Conference Marine Natural Products
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2016-03-08
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12740
[Presentation] Recent topics in natural product-derived protein phosphatase inhibitors2016
- Author(s)
  T. Wakimoto
- Organizer
  第93回日本生理学会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-03-22
- Invited
- Data Source
  KAKENHI-PROJECT-15K12740
[Presentation] Marine sponge-derived metagenomes/uncultured bacteria - a rich source of novel natural product biosynthetic genes2016
- Author(s)
  Toshiyuki Wakimoto
- Organizer
  Czech-Japan Joint Workshop
- Place of Presentation
  Prague, Czech Republic
- Year and Date
  2016-11-09
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03112
[Presentation] Activated Chemical Defense of a Sponge-Microbe Association2016
- Author(s)
  T. Wakimoto
- Organizer
  Gordon Research Conference Marine Natural Products
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2016-03-08
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03112
[Presentation] 難培養微生物を起源とする海綿由来生物活性物質の生合成研究2016
- Author(s)
  脇本敏幸
- Organizer
  日本農芸化学会2016年度大会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-03-30
- Invited
- Data Source
  KAKENHI-PROJECT-15K12740
[Presentation] 海綿動物由来生物活性物質の探索と生合成研究2016
- Author(s)
  脇本敏幸
- Organizer
  若手研究者のための有機化学札幌セミナー
- Place of Presentation
  北海道大学理学部（北海道札幌市）
- Year and Date
  2016-11-29
- Invited
- Data Source
  KAKENHI-PLANNED-16H06448
[Presentation] Marine sponge-derived metagenomes/uncultured bacteria - a rich source of novel natural product biosynthetic genes2016
- Author(s)
  Toshiyuki Wakimoto
- Organizer
  Czech-Japan Joint Workshop
- Place of Presentation
  Prague, Czech Republic
- Year and Date
  2016-11-09
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06448
[Presentation] A Bacterial Symbiont in Japanese Marine Sponges Produces Biologically Active Metabolites2016
- Author(s)
  Toshiyuki Wakimoto
- Organizer
  The 3rd Myanmar-Japan International Symposium
- Place of Presentation
  Pathein, Myanmar
- Year and Date
  2016-12-03
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12740
[Presentation] Marine sponge-derived metagenomes/uncultured bacteria - a rich source of novel natural product biosynthetic genes2016
- Author(s)
  Toshiyuki Wakimoto
- Organizer
  Czech-Japan Joint Workshop
- Place of Presentation
  Prague, Czech Republic
- Year and Date
  2016-11-09
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12740
[Presentation] A Bacterial Symbiont in Japanese Marine Sponges Produces Biologically Active Metabolites2016
- Author(s)
  Toshiyuki Wakimoto
- Organizer
  The 3rd Myanmar-Japan International Symposium
- Place of Presentation
  Pathein, Myanmar
- Year and Date
  2016-12-03
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03112
[Presentation] A Bacterial Symbiont in Japanese Marine Sponges Produces Biologically Active Metabolites2016
- Author(s)
  Toshiyuki Wakimoto
- Organizer
  The 3rd Myanmar-Japan International Symposium
- Place of Presentation
  Pathein, Myanmar
- Year and Date
  2016-12-03
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06448
[Presentation] Activated Chemical Defense of a Sponge-Microbe Association2016
- Author(s)
  Toshiyuki Wakimoto
- Organizer
  Gordon Research Conference, Marine Natural Products
- Place of Presentation
  Ventura, USA
- Year and Date
  2016-03-06
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26303005
[Presentation] 海綿動物由来生物活性物質の探索と生合成研究2016
- Author(s)
  脇本敏幸
- Organizer
  若手研究者のための有機化学札幌セミナー
- Place of Presentation
  北海道大学理学部（北海道札幌市）
- Year and Date
  2016-11-29
- Invited
- Data Source
  KAKENHI-PROJECT-15H03112
[Presentation] 海綿動物由来生物活性物質の探索と生合成研究2016
- Author(s)
  脇本敏幸
- Organizer
  若手研究者のための有機化学札幌セミナー
- Place of Presentation
  北海道大学理学部（北海道札幌市）
- Year and Date
  2016-11-29
- Invited
- Data Source
  KAKENHI-PROJECT-15K12740
[Presentation] A Bacterial Symbiont in Japanese Marine Sponges Produces Biologically Active Metabolites2016
- Author(s)
  T. Wakimoto
- Organizer
  The 4th Frontier Chemistry Center International Symposium
- Place of Presentation
  北海道大学（北海道札幌市）
- Year and Date
  2016-02-23
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03112
[Presentation] Recent topics in natural product-derived protein phosphatase inhibitors2016
- Author(s)
  T. Wakimoto
- Organizer
  第93回日本生理学会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-03-22
- Invited
- Data Source
  KAKENHI-PROJECT-15H03112
[Presentation] 難培養微生物を起源とする海綿由来生物活性物質の生合成研究2016
- Author(s)
  脇本敏幸
- Organizer
  日本農芸化学会2016年度大会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-03-30
- Invited
- Data Source
  KAKENHI-PROJECT-15H03112
[Presentation] 海綿―共生微生物系の化学防御機構2015
- Author(s)
  脇本敏幸
- Organizer
  第67回日本生物工学会
- Place of Presentation
  城山観光ホテル（鹿児島県鹿児島）
- Year and Date
  2015-10-27
- Invited
- Data Source
  KAKENHI-PROJECT-15K12740
[Presentation] The significance of unstable marine natural products2015
- Author(s)
  Toshiyuki Wakimoto
- Organizer
  Marine Biotechnology Seminar
- Place of Presentation
  Adelaide, Australia
- Year and Date
  2015-02-09
- Invited
- Data Source
  KAKENHI-PUBLICLY-25108705
[Presentation] Activated Chemical Defense of a Sponge-Microbe Association2015
- Author(s)
  Toshiyuki Wakimoto
- Organizer
  PACIFICHEM2015
- Place of Presentation
  Hawaii, USA
- Year and Date
  2015-12-15
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26303005
[Presentation] 海綿―共生微生物系の化学防御機構2015
- Author(s)
  脇本敏幸
- Organizer
  第67回日本生物工学会
- Place of Presentation
  城山観光ホテル（鹿児島県鹿児島市）
- Year and Date
  2015-10-27
- Invited
- Data Source
  KAKENHI-PROJECT-15H03112
[Presentation] The significance of unstable marine natural products2015
- Author(s)
  Toshiyuki Wakimoto
- Organizer
  Marine Biotechnology Seminar
- Place of Presentation
  Adelaide, Australia
- Year and Date
  2015-02-09
- Invited
- Data Source
  KAKENHI-PROJECT-25560399
[Presentation] 海洋天然物化学が明示した難培養微生物の存在2015
- Author(s)
  脇本敏幸
- Organizer
  第50回天然物化学談話会
- Place of Presentation
  グリーンピア岩沼（宮城県岩沼市）
- Year and Date
  2015-07-03
- Invited
- Data Source
  KAKENHI-PROJECT-15H03112
[Presentation] 海綿―共生微生物系の化学防御機構2015
- Author(s)
  脇本敏幸
- Organizer
  第10回化学生態学研究会
- Place of Presentation
  湯の川プリンスホテル渚亭（北海道函館市）
- Year and Date
  2015-06-13
- Invited
- Data Source
  KAKENHI-PROJECT-15K12740
[Presentation] 海洋天然物化学が明示した難培養微生物の存在2015
- Author(s)
  脇本敏幸
- Organizer
  第50回天然物化学談話会
- Place of Presentation
  グリーンピア岩沼（宮城県岩沼市）
- Year and Date
  2015-07-03
- Invited
- Data Source
  KAKENHI-PROJECT-15K12740
[Presentation] 海綿―共生微生物系の化学防御機構2015
- Author(s)
  脇本敏幸
- Organizer
  第10回化学生態学研究会
- Place of Presentation
  湯の川プリンスホテル渚亭（北海道函館市）
- Year and Date
  2015-06-13
- Invited
- Data Source
  KAKENHI-PROJECT-15H03112
[Presentation] 多様な天然物を生産する海綿共生バクテリア2014
- Author(s)
  脇本敏幸
- Organizer
  静岡大学農学部公開講演会
- Place of Presentation
  静岡県静岡市
- Year and Date
  2014-07-14
- Invited
- Data Source
  KAKENHI-PUBLICLY-25108705
[Presentation] 多様な天然物を生産する海綿共生バクテリア2014
- Author(s)
  脇本敏幸
- Organizer
  静岡大学農学部公開講演会
- Place of Presentation
  静岡県静岡市
- Year and Date
  2014-07-14
- Invited
- Data Source
  KAKENHI-PROJECT-25560399
[Presentation] 海綿由来生物活性物質の生合成に関する研究2014
- Author(s)
  脇本敏幸
- Organizer
  日本生薬学会第61年会
- Place of Presentation
  福岡県福岡市
- Year and Date
  2014-09-14
- Invited
- Data Source
  KAKENHI-PUBLICLY-25108705
[Presentation] 海綿由来生物活性物質の生合成に関する研究2014
- Author(s)
  脇本敏幸
- Organizer
  日本生薬学会第61年会
- Place of Presentation
  福岡県福岡市
- Year and Date
  2014-09-14
- Invited
- Data Source
  KAKENHI-PROJECT-25560399
[Presentation] A bacterial symbiont of Japanese marine sponge Discodermia calyx, produces biologically active metabolites2013
- Author(s)
  T. Wakimoto, Y. Egami, Y. Nakashima, I. Abe
- Organizer
  9th World Sponge Conference
- Place of Presentation
  Perth, Australia
- Invited
- Data Source
  KAKENHI-PUBLICLY-25108705
[Presentation] A bacterial symbiont of Japanese marine sponge Discodermia calyx, produces biologically active metabolites2013
- Author(s)
  T. Wakimoto, Y. Egami, Y. Nakashima, I. Abe
- Organizer
  The 14th International Symposium of Marine Natural Products
- Place of Presentation
  La Toja, Spain
- Invited
- Data Source
  KAKENHI-PROJECT-25560399
[Presentation] A bacterial symbiont of Japanese marine sponge Discodermia calyx, produces biologically active metabolites2013
- Author(s)
  T. Wakimoto, Y. Egami, Y. Nakashima, I. Abe
- Organizer
  9th World Sponge Conference
- Place of Presentation
  Perth, Australia
- Invited
- Data Source
  KAKENHI-PROJECT-25560399
[Presentation] A bacterial symbiont of Japanese marine sponge Discodermia calyx, produces biologically active metabolites2013
- Author(s)
  T. Wakimoto, Y. Egami, Y. Nakashima, I. Abe
- Organizer
  The 14th International Symposium of Marine Natural Products
- Place of Presentation
  La Toja, Spain
- Invited
- Data Source
  KAKENHI-PUBLICLY-25108705
[Presentation] 海綿Discodermia calyx由来メタゲノムライブラリーからの抗菌活性化合物の単離2012
- Author(s)
  賀蕊、江上蓉子，脇本敏幸，阿部郁朗
- Organizer
  日本薬学会第１３２年会
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-23710250
[Presentation] Calyculin Aの構造を基にした化合物ライブラリー構築による選択的ホスファターゼ阻害剤の創製2012
- Author(s)
  村松孝洋、脇本敏幸、阿部郁朗
- Organizer
  日本生薬学会　第59年会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-23710250
[Presentation] 海綿天然物Calyculin A生合成遺伝子クラスターのクローニング2012
- Author(s)
  江上蓉子、脇本敏幸、伊藤卓也、浅川義範、阿部郁朗
- Organizer
  日本薬学会第１３２年会
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-23710250
[Presentation] Calyculin A 生合成遺伝子クラスターの探索2012
- Author(s)
  脇本敏幸
- Organizer
  日本薬学会第 132 年会
- Place of Presentation
  (札幌)シンポジウム
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-23710250
[Presentation] 海綿由来細胞毒性物質、カリクリンのAの生合成遺伝子クラスターの探索2012
- Author(s)
  脇本敏幸、江上蓉子、阿部郁朗
- Organizer
  日本薬学会第１３２年会(招待講演)
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-23710250
[Presentation] 不安定天然物の探索2012
- Author(s)
  脇本敏幸
- Organizer
  日本生薬学会　第59年会
- Place of Presentation
  千葉
- Invited
- Data Source
  KAKENHI-PROJECT-23710250
[Presentation] 海綿内共生微生物由来の生物活性物質の探索研究2012
- Author(s)
  竹重勇哉、Karen TAN、脇本敏幸、江上蓉子、阿部郁朗
- Organizer
  日本薬学会第１３２年会
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-23710250
[Presentation] Calyculin生合成遺伝子クラスターの探索2012
- Author(s)
  脇本敏幸
- Organizer
  第７回化学生態学研究会
- Place of Presentation
  函館
- Invited
- Data Source
  KAKENHI-PROJECT-23710250
[Presentation] 海綿Discordemia calyxに含まれる新規環状ペプチドcalyxamide Aの単離と構造決定2011
- Author(s)
  木村美樹，脇本敏幸，阿部郁朗
- Organizer
  日本生薬学会第５８回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23710250
[Presentation] Search for the biosynthetic gene cluster of the cytotoxic polyketide calyculin A from the marine sponge Discodermia calyx2011
- Author(s)
  Toshiyuki Wakimoto
- Organizer
  University of Bristol(招待講演)
- Place of Presentation
  Bristol, UK
- Data Source
  KAKENHI-PROJECT-23710250
[Presentation] Search for the biosynthetic gene cluster of the cytotoxic polyketide calyculin A from the marine sponge Discodermia calyx2011
- Author(s)
  脇本敏幸
- Place of Presentation
  University of Tubingen (Tubingen, Germany)
- Year and Date
  2011-10-27
- Data Source
  KAKENHI-PROJECT-23710250
[Presentation] Search for the biosynthetic gene cluster of the cytotoxic polyketide calyculin A from the marine sponge Discodermia calyx2011
- Author(s)
  Toshiyuki Wakimoto
- Organizer
  University of Bonn(招待講演)
- Place of Presentation
  Bonn, Germany
- Data Source
  KAKENHI-PROJECT-23710250
[Presentation] 植物ポリケタイド合成酵素の合理的な酵素触媒機能の拡張による非天然型新規生理活性物質の創出2011
- Author(s)
  森田洋行，森貴裕，山下誠，脇本敏幸，阿部郁朗
- Organizer
  第５３回天然有機化合物討論会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23710250
[Presentation] Chemistry and biology of calyculin A2011
- Author(s)
  脇本敏幸
- Organizer
  The 6th Korea-Japan Young Scientists Symposium
- Place of Presentation
  Seoul, Korea
- Year and Date
  2011-06-24
- Data Source
  KAKENHI-PROJECT-23710250
[Presentation] Search for the biosynthetic gene cluster of the cytotoxic polyketide calyculin A from the marine sponge Discodermia calyx2011
- Author(s)
  Toshiyuki Wakimoto
- Organizer
  University of Tubingen(招待講演)
- Place of Presentation
  Tubingen, Germany
- Data Source
  KAKENHI-PROJECT-23710250
[Presentation] Search for the biosynthetic gene cluster of the cytotoxic polyketide calyculin A from the marine sponge Discodermia calyx2011
- Author(s)
  脇本敏幸
- Place of Presentation
  University of Bonn (Bonn, Germany)
- Year and Date
  2011-11-22
- Data Source
  KAKENHI-PROJECT-23710250
[Presentation] Search for the biosynthetic gene cluster of the cytotoxic polyketide calyculin A from the marine sponge Discodermia calyx2011
- Author(s)
  脇本敏幸
- Organizer
  University of Bristol
- Place of Presentation
  University of Bristol (Bristol, UK)
- Year and Date
  2011-11-22
- Data Source
  KAKENHI-PROJECT-23710250
[Presentation] 海洋天然物Calyculin Aの蛍光標識2011
- Author(s)
  但馬大紀，脇本敏幸，阿部郁朗
- Organizer
  日本生薬学会第５８回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23710250
[Presentation] Anti-inflammatory activity of furan fatty acid2009
- Author(s)
  T. Wakimoto, H. Kondou, K. Tsuji, T. kan
- Organizer
  The 5th Takeda Science Foundation Symposium on PharmaSciences
- Place of Presentation
  Tokyo
- Year and Date
  2009-05-25
- Data Source
  KAKENHI-PROJECT-19780162
[Presentation] Anti-inflammatory activity of furan fatty acid2009
- Author(s)
  脇本敏幸
- Organizer
  The 5th takeda Science Foundation Symposium on PharmaSciences
- Place of Presentation
  東京
- Year and Date
  2009-05-25
- Data Source
  KAKENHI-PROJECT-19780162
[Presentation] 緑イ貝中の抗炎症活性物質の探索2008
- Author(s)
  脇本敏幸
- Organizer
  平成20年度日本水産学会春季大会
- Place of Presentation
  静岡
- Year and Date
  2008-03-30
- Data Source
  KAKENHI-PROJECT-19780162
[Presentation] 緑イ貝中の抗炎症活性物質の探索2008
- Author(s)
  脇本敏幸、近藤光、末永聖武、石田均司、辻邦郎、糠谷東雄
- Organizer
  平成20年度日本水産学会春季大会
- Place of Presentation
  静岡
- Year and Date
  2008-03-30
- Data Source
  KAKENHI-PROJECT-19780162
[Presentation] 緑イ貝中の抗炎症活性成分の探索2008
- Author(s)
  近藤光、脇本敏幸、末永聖武、石田均司、辻邦郎、糠谷東雄
- Organizer
  日本薬学会年会128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-19780162
[Presentation] 緑イ貝中の抗炎症活性物質の探索2007
- Author(s)
  脇本敏幸
- Organizer
  第21回海洋生物活性談話会
- Place of Presentation
  鹿児島
- Year and Date
  2007-05-19
- Data Source
  KAKENHI-PROJECT-19780162
[Presentation] 緑イ貝中の微量抗酸化活性脂質と抗炎症作用について2007
- Author(s)
  脇本敏幸
- Organizer
  日本農芸化学会中部支部第151回例会若手シンポジウム
- Place of Presentation
  静岡
- Year and Date
  2007-11-17
- Data Source
  KAKENHI-PROJECT-19780162
[Presentation] 緑イ貝中の微量抗酸化性脂質と抗炎症作用について2007
- Author(s)
  脇本敏幸
- Organizer
  日本農芸化学会、中部支部第151回例会若手シンポジウム
- Place of Presentation
  静岡
- Year and Date
  2007-11-17
- Data Source
  KAKENHI-PROJECT-19780162
[Presentation] 緑イ貝中の抗炎症活性物質の探索2007
- Author(s)
  脇本敏幸
- Organizer
  第2回化学生態学研究会
- Place of Presentation
  函館
- Year and Date
  2007-07-21
- Data Source
  KAKENHI-PROJECT-19780162
[Presentation] 緑イ貝中の抗炎症活性物質の探索2007
- Author(s)
  脇本敏幸、末永聖武、石田均司、辻邦郎、糠谷東雄
- Organizer
  第21回海洋生物活性談話会
- Place of Presentation
  鹿児島
- Year and Date
  2007-05-19
- Data Source
  KAKENHI-PROJECT-19780162
[Presentation] 緑イ貝中の抗炎症活性物質の探索2007
- Author(s)
  脇本敏幸
- Organizer
  第2回化学生態学研究会
- Place of Presentation
  函館
- Year and Date
  2007-07-21
- Data Source
  KAKENHI-PROJECT-19780162
[Presentation] 海洋生物に由来する医薬品資源の開拓と利用を目指して
- Author(s)
  脇本敏幸
- Organizer
  第34回和漢医薬学総合研究所特別セミナー
- Place of Presentation
  富山県富山市
- Invited
- Data Source
  KAKENHI-PROJECT-25560399
[Presentation] 海洋生物に由来する医薬品資源の開拓と利用を目指して
- Author(s)
  脇本敏幸
- Organizer
  福井県立大学　生物資源学特別セミナー
- Place of Presentation
  福井県福井市
- Invited
- Data Source
  KAKENHI-PUBLICLY-25108705
[Presentation] 海綿共生微生物を起源とする生理活性物質の生産機構解析
- Author(s)
  脇本敏幸
- Organizer
  第1回薬学の有機化学を考えるin北海道
- Place of Presentation
  北海道札幌市
- Invited
- Data Source
  KAKENHI-PROJECT-25560399
[Presentation] 海洋生物に由来する医薬品資源の開拓と利用を目指して
- Author(s)
  脇本敏幸
- Organizer
  第34回和漢医薬学総合研究所特別セミナー
- Place of Presentation
  富山県富山市
- Invited
- Data Source
  KAKENHI-PUBLICLY-25108705
[Presentation] 海洋生物に由来する医薬品資源の開拓と利用を目指して
- Author(s)
  脇本敏幸
- Organizer
  福井県立大学　生物資源学特別セミナー
- Place of Presentation
  福井県福井市
- Invited
- Data Source
  KAKENHI-PROJECT-25560399
[Presentation] 海綿共生微生物を起源とする生理活性物質の生産機構解析
- Author(s)
  脇本敏幸
- Organizer
  第1回薬学の有機化学を考えるin北海道
- Place of Presentation
  北海道札幌市
- Invited
- Data Source
  KAKENHI-PUBLICLY-25108705
[]

1. ABE IKURO (40305496)

# of Collaborated Projects: 5 results

# of Collaborated Products: 16 results
2. AWAKAWA Takayoshi (80609834)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
3. 葛山智久 (30280952)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
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# of Collaborated Projects: 3 results

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6. MATSUDA Yudai (10720766)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
7. MORITA Hiroyuki (20416663)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
8. EGAMI Yoko (50758612)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
9. 菅裕明 (00361668)

# of Collaborated Projects: 2 results

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10. 梅野太輔 (00400812)

# of Collaborated Projects: 2 results

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11. 南篤志 (40507191)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 濱野吉十 (50372834)

# of Collaborated Projects: 2 results

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13. 江口正 (60201365)

# of Collaborated Projects: 2 results

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14. 大利徹 (70264679)

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15. 池田治生 (90159632)

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16. NAKAO Yoichi (60282696)

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17. HORI Kanji (50116662)

# of Collaborated Projects: 1 results

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18. SAKAI Ryuichi (20265721)

# of Collaborated Projects: 1 results

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19. FUSETANI Nobuhiro (70012010)

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21. FUKUZAWA Seketsu (40321806)

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22. FUJITA Masaki (30505251)

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23. TAKADA Kentarou (90455353)

# of Collaborated Projects: 1 results

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24. SUGIO Shigetoshi (10537343)

# of Collaborated Projects: 1 results

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25. NOGUCHI Hiroshi (60126141)

# of Collaborated Projects: 1 results

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26. KUSHIRO Testuo (80373299)

# of Collaborated Projects: 1 results

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# of Collaborated Projects: 1 results

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35. 神尾道也 (30578852)

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36. 和田哲 (40325402)

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37. 千葉晋 (00385501)

# of Collaborated Projects: 1 results

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38. 山家秀信 (40423743)

# of Collaborated Projects: 1 results

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39. URIA AGUSTINUS

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
40. LIU MIAOMIAO

# of Collaborated Projects: 1 results

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41. Abe Kohtaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. Hirano Mayumi

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# of Collaborated Products: 1 results
43. ASAKAWA Tomohiro

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44. 平野勝也

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45. 吉村彩

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47. YANG Xiao-Long

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48. 尾仲宏康

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
49. Uria Agustinus・Robert

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
50. 神谷充伸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Wakimoto Toshiyuki 脇本 敏幸

WAKIMOTO Toshiyuki 脇本 敏幸

Research Projects

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Co-Researchers

環状ペプチドの化学酵素合成による新規農薬モダリティの開拓Principal Investigator

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Search for new natural products derived from rare microorganismsPrincipal Investigator

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新規ペプチド修飾酵素の機能拡張による大環状複雑骨格の創出Principal Investigator

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Genome mining of rare microbial strains for natural drug resourcesPrincipal Investigator

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Biosynthetic gene cluster of bioactive natural products from marine invertebratesPrincipal Investigator

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Biosynthetic study on bioactive compounds from marine spongesPrincipal Investigator

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Production of rare bioactive natural products originating from uncultured bacteriaPrincipal Investigator

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The mechanism regulating the function of a natural cytotoxinPrincipal Investigator

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Research Institution

Bioactive secondary metabolites produced by sponge symbiont EntotheonellaPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Principal Investigator

Wakimoto Toshiyuki 脇本敏幸

WAKIMOTO Toshiyuki 脇本敏幸