TSUKAMOTO HIROKI 塚本宏樹

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TSUKAMOTO Hiroki 塚本宏樹

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Researcher Number	70423605
Other IDs
Affiliation (Current)	2025: 国際医療福祉大学, 福岡薬学部, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 国際医療福祉大学, 福岡薬学部, 准教授 2016 – 2019: 東北大学, 薬学研究科, 助教 2017: 東北大学, 大学院薬学研究科, 助教 2013 – 2015: 東北大学, 薬学研究科(研究院), 助教 2011 – 2012: 佐賀大学, 医学部, 助教 … More 2007 – 2009: Saga University, 医学部, 助教 2007: 佐賀大, 医学部, 助手 2006: 佐賀大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Drug development chemistry / Biological pharmacy Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Medical Physics and Radiological Technology / Tumor diagnostics / Immunology
Keywords	Principal Investigator Toll様受容体 / 自然免疫 / モノクローナル抗体 / 抗体 / 免疫学 / PD-L1 / 低分子創薬 / 免疫チェックポイント / がん免疫療法 / 抗体医薬 … More / リポ多糖 / MDSC / 貪食 / 肥満細胞 / IgE / マクロファージ / 樹状細胞 / 食物アレルギー / 免疫抑制経路阻害薬 / 複合がん免疫療法 / PD-1 / アデノシン / 低分子薬 / 腫瘍免疫 / アジュバント / アデノシン受容体 / CD73 / 制御性T細胞 / １型糖尿病 / Toll-like receptor / 骨髄由来免疫抑制細胞 / 機能性抗体 / 免疫寛容 / 1型糖尿病 / 自己免疫疾患 / 敗血症 / MD-2 / TLR4 / 生体分子 / 薬学 / 感染症 / シグナル伝達 / 薬理学 / 癌 … More Except Principal Investigator CD73 / メタボロミクス / アデノシン / 免疫制御 / ＣＤ３９ / ＣＤ７３ / 免疫抑制 / 化合物ライブラリー / エクソソーム / compound library / inhibitors / CD39 / がん細胞 / 脂肪酸合成酵素 / プロテオミクス / 放射線耐性 / 腫瘍マーカー / LC/MS / がん免疫 / 修飾核酸 / 感染防御 / 自然免疫 / 刺激型抗体 / LPS / TLR4/MD-2 / 免疫賦活 / 抗体 Less

低分子免疫チェックポイント阻害化合物による複合がん免疫療法の創薬基盤研究Principal Investigator
- Principal Investigator
  
  塚本宏樹
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  International University of Health and Welfare
TLR4刺激抗体の食物アレルギー抑制機序解明による新規アレルギー予防・治療戦略Principal Investigator
- Principal Investigator
  
  塚本宏樹
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  International University of Health and Welfare
Search for molecules that control the CD39-CD73-adenosine cascade and expand into drug discovery
- Principal Investigator
  
  Tomioka Yoshihisa
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tohoku University
Combination cancer immunotherapy with antigen-specific agonistic TLR4 antibody and immune checkpoint inhibitorsPrincipal Investigator
- Principal Investigator
  
  TSUKAMOTO HIROKI
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  International University of Health and Welfare
  Tohoku University
Investigation of the modified nucleic acid for novel cancer evaluation marker candidates and its diagnostic application.
- Principal Investigator
  
  Tomioka Yoshihisa
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor diagnostics
- Research Institution
  Tohoku University
Elucidation of the mechanism of radioresistance in cancer cells using trans-omics approach and development of clinical biomarkers for radiotherapy.
- Principal Investigator
  
  Kanemitsu Yoshitomi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical Physics and Radiological Technology
- Research Institution
  Tohoku University
A novel immunotherapy of autoimmune disease by agonistic toll-like receptor 4 antibodyPrincipal Investigator
- Principal Investigator
  
  TSUKAMOTO HIROKI
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku University
Novel regulatory mechanism of human Toll-like receptor 4 function by the inhibitory monoclonal antibodyPrincipal Investigator
- Principal Investigator
  
  TSUKAMOTO HIROKI
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tohoku University
  Saga University
Aanalysis of immune activation and protective mechanisms against infection using agonistic anti-TLR4 mAb
- Principal Investigator
  
  KIMOTO Masao
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Saga University
Recognition of lipopolysaccharide by adiponectinPrincipal Investigator
- Principal Investigator
  
  TSUKAMOTO Hiroki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Saga University
刺激型抗TLR抗体による新しい癌の治療法の理論構築と創薬開発への応用Principal Investigator
- Principal Investigator
  
  塚本宏樹
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Drug development chemistry
- Research Institution
  Saga University

[Book] Bioactive Lipid Mediators-Current Reviews and Protocols2015
- Author(s)
  Takahashi T, Saigusa D, Takeda C, Saito K, Suzuki N, Tsukamoto H, Tomioka Y
- Total Pages
  426
- Publisher
  Springer Japan
- Data Source
  KAKENHI-PROJECT-26460058
[Book] Handbook of Glycosyltransferases and Related Genes, 2nd ed2014
- Author(s)
  Ikeda Y, Ihara H, Tsukamoto H, Gu J, Taniguchi N
- Total Pages
  1717
- Publisher
  Springer Japan
- Data Source
  KAKENHI-PROJECT-24790112
[Book] Handbook of Glycosyltransferases and Related Genes, 2nd ed2014
- Author(s)
  Ihara H, Tsukamoto H, Gu J, Miyoshi E, Taniguchi N, Ikeda Y
- Total Pages
  1717
- Publisher
  Springer Japan
- Data Source
  KAKENHI-PROJECT-24790112
[Book] Handbook of Glycosyltransferases and Related Genes, Mannosyl (β-1,4-)-glycoproteinβ-1,4-N-acetylglucosaminyltransferase (MGAT3);β1,4-N-Acetylglucosaminyltransferase III (GnT-III, GlcNAc-T III)(Taniguchi N, Honke K, Fukuda M, Narimatsu H, Yamaguchi Y, Angata T, eds)2014
- Author(s)
  Ikeda Y, Ihara H, Tsukamoto H, Gu J, Taniguchi N
- Publisher
  Springer Japan (Tokyo, Japan)
- Data Source
  KAKENHI-PROJECT-24790112
[Book] Handbook of Glycosyltransferases and Related Genes(FUT8), Fucosyltransferase 8. GDP-fucose N-glycan coreα6-fucosyltransferase(Taniguchi N, Honke K, Fukuda M, Narimatsu H, Yamaguchi Y, Angata T, eds)2014
- Author(s)
  Ihara H, Tsukamoto H, Gu J, Miyoshi E, Taniguchi N, Ikeda Y
- Publisher
  Springer Japan (Tokyo, Japan)
- Data Source
  KAKENHI-PROJECT-24790112
[Journal Article] Endosomal Sequestration of TLR4 Antibody Induces Myeloid-Derived Suppressor Cells and Reverses Acute Type 1 Diabetes2022
- Author(s)
  Locker Kathryn C.S.、Kachapati Kritika、Wu Yuehong、Bednar Kyle J.、Adams David、Patel Caroline、Tsukamoto Hiroki、Heuer Luke S.、Aronow Bruce J.、Herr Andrew B.、Ridgway William M.
- Journal Title
  
  Diabetes
  
  Volume: 71 Issue: 3 Pages: 470-482
- DOI
  10.2337/db21-0426
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06532
[Journal Article] Toll様受容体4刺激抗体による食物アレルギー治療効果2022
- Author(s)
  塚本宏樹
- Journal Title
  
  アレルギーの臨床
  
  Volume: 7月号 Pages: 766-769
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06532
[Journal Article] The impact of cell maturation and tissue microenvironments on the expression of endosomal Toll-like receptors in monocytes and macrophages2020
- Author(s)
  Sato R, Reuter T, Hiranuma R, Shibata T, Fukui R, Motoi Y, Murakami Y, Tsukamoto H, Yamazaki S, Liu K, Saitoh SI, Latz E, Miyake K.
- Journal Title
  
  Int Immunol
  
  Volume: 32 Issue: 12 Pages: 785-798
- DOI
  10.1093/intimm/dxaa055
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21612, KAKENHI-PUBLICLY-18H04856, KAKENHI-PUBLICLY-20H04900, KAKENHI-PUBLICLY-20H05025, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-20H03466, KAKENHI-PROJECT-20H03707, KAKENHI-PROJECT-18K06651, KAKENHI-PROJECT-18K07169, KAKENHI-PROJECT-19K16685, KAKENHI-PROJECT-19H03451, KAKENHI-PROJECT-19K22635
[Journal Article] Impaired antigen‐specific lymphocyte priming in mice after Toll‐like receptor 4 activation via induction of monocytic myeloid‐derived suppressor cells2019
- Author(s)
  Tsukamoto Hiroki、Kozakai Sao、Kobayashi Yohei、Takanashi Risako、Aoyagi Takuya、Numasaki Muneo、Ohta Shoichiro、Tomioka Yoshihisa
- Journal Title
  
  European Journal of Immunology
  
  Volume: 49 Issue: 4 Pages: 546-563
- DOI
  10.1002/eji.201847805
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06651, KAKENHI-PROJECT-15K09553, KAKENHI-PROJECT-18K08262
[Journal Article] Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease2019
- Author(s)
  Kikuchi Koichi、Saigusa Daisuke、Kanemitsu Yoshitomi、Matsumoto Yotaro、Tsukamoto Hiroki、Abe Takaaki
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1 Pages: 1835-1835
- DOI
  10.1038/s41467-019-09735-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06651, KAKENHI-PROJECT-18K06742, KAKENHI-PROJECT-18K07076, KAKENHI-PROJECT-18K08198, KAKENHI-PROJECT-18K08199, KAKENHI-PLANNED-17H06394, KAKENHI-PUBLICLY-18H04805, KAKENHI-PROJECT-19H03557, KAKENHI-PROJECT-19H03675, KAKENHI-PROJECT-17K00856
[Journal Article] An agonistic anti‐Toll‐like receptor 4 monoclonal antibody as an effective adjuvant for cancer immunotherapy2019
- Author(s)
  Tsukamoto Hiroki、Kubota Kanae、Shichiku Ayumi、Maekawa Masamitsu、Mano Nariyasu、Yagita Hideo、Ohta Shoichiro、Tomioka Yoshihisa
- Journal Title
  
  Immunology
  
  Volume: 158 Issue: 2 Pages: 136-149
- DOI
  10.1111/imm.13095
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06651
[Journal Article] Lipopolysaccharide (LPS)-binding protein stimulates CD14-dependent Toll-like receptor 4 internalization and LPS-induced TBK1-IKKε-IRF3 axis activation2018
- Author(s)
  Tsukamoto Hiroki、Takeuchi Shino、Kubota Kanae、Kobayashi Yohei、Kozakai Sao、Ukai Ippo、Shichiku Ayumi、Okubo Misaki、Numasaki Muneo、Kanemitsu Yoshitomi、Matsumoto Yotaro、Nochi Tomonori、Watanabe Kouichi、Aso Hisashi、Tomioka Yoshihisa
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 293 Issue: 26 Pages: 10186-10201
- DOI
  10.1074/jbc.m117.796631
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06651, KAKENHI-PROJECT-17K19882, KAKENHI-PROJECT-18H03969
[Journal Article] Generation and Characterization of Anti-phenyl Sulfate Monoclonal Antibodies and a Potential Use for Phenyl Sulfate Analysis in Human Blood2018
- Author(s)
  Kanemitsu Yoshitomi、Tsukamoto Hiroki、Matsumoto Yotaro、Nozawa-Kumada Kanako、Kondo Yoshinori、Abe Takaaki、Tomioka Yoshihisa
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 41 Issue: 8 Pages: 1170-1177
- DOI
  10.1248/bpb.b17-00925
- NAID
  130007429804
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2018-08-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06651, KAKENHI-PROJECT-17K15418
[Journal Article] Evaluation of the impact of gut microbiota on uremic solute accumulation by a CE-TOFMS-based metabolomics approach2017
- Author(s)
  †Mishima, E., †Fukuda, S. (†equally contributed), Mukawa, C., Yuri, A., Kanemitsu, Y., Matsumoto, Y., Akiyama, Y., Fukuda, NN., Tsukamoto, H., Asaji, K., Shima, H., Kikuchi, K., Suzuki, T., Tomioka, Y., Soga, T., Ito, S., Abe, T.
- Journal Title
  
  Kidney International
  
  Volume: 92 Issue: 3 Pages: 634-645
- DOI
  10.1016/j.kint.2017.02.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H04901, KAKENHI-PROJECT-16K19474, KAKENHI-PROJECT-16K20909
[Journal Article] Rapid and selective simultaneous quantitative analysis of modified nucleosides using multi-column liquid chromatography-tandem mass spectrometry.2017
- Author(s)
  4.Jinno D, Kanemitsu Y, Saitoh K, Nankumo S, Tsukamoto H, Matsumoto Y, Abe T, Tomioka Y
- Journal Title
  
  J Anal Sci Technol.
  
  Volume: 8 Issue: 1 Pages: 1-9
- DOI
  10.1186/s40543-017-0110-4
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H04704, KAKENHI-PROJECT-26460058
[Journal Article] An inhibitory epitope of human Toll-like receptor 4 resides on leucine-rich repeat 13 and is recognized by a monoclonal antibody2017
- Author(s)
  Tsukamoto Hiroki、Yamagata Yuki、Ukai Ippo、Takeuchi Shino、Okubo Misaki、Kobayashi Yohei、Kozakai Sao、Kubota Kanae、Mumasaki Muneo、Kanemitsu Yoshitomi、Matsumoto Yotaro、Tomioka Yoshihisa
- Journal Title
  
  FEBS Letters
  
  Volume: 591 Issue: 16 Pages: 2406-2416
- DOI
  10.1002/1873-3468.12768
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K20909
[Journal Article] Toll様受容体4抑制抗体の作用機序とそのエピトープ2016
- Author(s)
  塚本宏樹
- Journal Title
  
  細胞
  
  Volume: 48(4) Pages: 50-52
- Data Source
  KAKENHI-PROJECT-26460058
[Journal Article] TEX101, a glycoprotein essential for sperm fertility, is required for stable expression of Ly6k on testicular germ cells2016
- Author(s)
  Endo S, Yoshitake H, Tsukamoto H, Matsuura H, Kato K, Sakuraba M, Takamori K, Fujiwara H, Takeda S, Araki Y
- Journal Title
  
  Sci Rep
  
  Volume: 6 Issue: 1 Pages: 23616-23616
- DOI
  10.1038/srep23616
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460058, KAKENHI-PROJECT-25460727, KAKENHI-PROJECT-25462575, KAKENHI-PROJECT-16K11111
[Journal Article] Anti-tumor immunity elicited by direct intratumoral administration of a recombinant adenovirus expressing either IL-28A/IFN-λ2 or IL-29/IFN-λ1.2016
- Author(s)
  Hasegawa K, Tagawa M, Takagi K, Tsukamoto H, Tomioka Y, Suzuki T, Nishioka Y, Ohrui T, Numasaki M.
- Journal Title
  
  Cancer Gene Ther
  
  Volume: 23(8) Issue: 8 Pages: 266-277
- DOI
  10.1038/cgt.2016.29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05309, KAKENHI-PROJECT-26460058, KAKENHI-PROJECT-26670418, KAKENHI-PROJECT-16K08645
[Journal Article] イナビル添加乳糖に夾雑する乳タンパク質によってアナフィラキシーを呈した1例2016
- Author(s)
  森川みき、金光祥臣、塚本宏樹、富岡佳久
- Journal Title
  
  アレルギー
  
  Volume: 65(3)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460058
[Journal Article] A Heterodimeric Cytokine, Consisting of IL-17A and IL-17F, Promotes Migration and Capillary-Like Tube Formation of Human Vascular Endothelial Cells2016
- Author(s)
  Numasaki M, Tsukamoto H, Tomioka Y, Nishioka Y, Ohrui T.
- Journal Title
  
  Tohoku J. Exp. Med.
  
  Volume: 240 Issue: 1 Pages: 47-56
- DOI
  10.1620/tjem.240.47
- NAID
  130005261734
- ISSN
  0040-8727, 1349-3329
- Language
  English
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05309, KAKENHI-PROJECT-26460058, KAKENHI-PROJECT-26670418, KAKENHI-PROJECT-26460900
[Journal Article] Leucine-rich repeat 2 of human Toll-like receptor 4 contains the binding site for inhibitory monoclonal antibodies2015
- Author(s)
  Tsukamoto H, Ukai I, Yamagata Y, Takeuchi S, Kubota K, Kozakai S, Suzuki N, Kimoto M, Tomioka Y
- Journal Title
  
  FEBS Lett
  
  Volume: 589(24 Pt B) Issue: 24PartB Pages: 3893-3898
- DOI
  10.1016/j.febslet.2015.11.018
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460058
[Journal Article] Reversal of New-Onset Type 1 Diabetes With an Agonistic TLR4/MD-2 Monoclonal Antibody2015
- Author(s)
  Bednar, K.J., Tsukamoto, H., Kachapati, K., Ohta, S., Wu, Y., Katz, J.D., Ascherman, D.P. & Ridgway, W.M.
- Journal Title
  
  Diabetes
  
  Volume: 64 Issue: 10 Pages: 3614-3626
- DOI
  10.2337/db14-1868
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09553, KAKENHI-PROJECT-26460058
[Journal Article] Multi-inhibitory effects of A2A adenosine receptor signaling on neutrophil adhesion under flow2015
- Author(s)
  Yago T, Tsukamoto H, Liu Z, Wang Y, Thompson LF, McEver RP
- Journal Title
  
  J Immunol
  
  Volume: 195(8) Issue: 8 Pages: 3880-3889
- DOI
  10.4049/jimmunol.1500775
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460058
[Journal Article] 【研究戦略・YAKU学～研究現場から～】機能性抗体によるToll様受容体の活性制御を基盤とした敗血症治療薬開発2015
- Author(s)
  塚本宏樹
- Journal Title
  
  薬事日報
  
  Volume: 11542 Pages: 8-8
- Data Source
  KAKENHI-PROJECT-26460058
[Journal Article] Immune regulation via the generation of extracellular adenosine by CD732014
- Author(s)
  Tsukamoto H
- Journal Title
  
  Seikagaku
  
  Volume: 86 Pages: 766-769
- NAID
  40020314143
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460058
[Journal Article] Extracellular Adenosine Is a Therapeutic Target for Limiting Graft-<i>versus</i>-Host Disease and Enhancing the Graft-<i>versus</i>-Tumor Effect against Hematopoietic Malignancy2014
- Author(s)
  Tsukamoto H
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 134 Issue: 10 Pages: 1021-1027
- DOI
  10.1248/yakushi.14-00184
- NAID
  130004693882
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2014-10-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460058
[Journal Article] A validated quantitative liquid chromatography-tandem quadrupole mass spectrometry method for monitoring isotopologues to evaluate global modified cytosine ratios in genomic DNA2014
- Author(s)
  Tsuji M, Matsunaga H, Jinno D, Tsukamoto H, Suzuki N, Tomioka Y
- Journal Title
  
  J Chromatogr B Analyt Technol Biomed Life Sci
  
  Volume: 953-954 Pages: 38-47
- DOI
  10.1016/j.jchromb.2014.01.050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790112, KAKENHI-PROJECT-25430135, KAKENHI-PROJECT-26460058
[Journal Article] Inhibition of antibody production in vivo by pre-stimulation of Toll-like receptor 4 before antigen priming is caused by defective B cell priming and not impairment in antigen presentation.2013
- Author(s)
  Nurlaely Mida Rachmawati, Kenji Fukudome, Naoko Tsuneyoshi, Uleng Bahrun, Hiroki Tsukamoto, Tsutomu Yanagibashi, Yoshinori Nagai, Kiyoshi Takatsu, Shoichiro Ohta, and Masao Kimoto
- Journal Title
  
  International Immunology
  
  Volume: 25 Issue: 2 Pages: 117-128
- DOI
  10.1093/intimm/dxs096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591466, KAKENHI-PROJECT-24790112, KAKENHI-PUBLICLY-24117708
[Journal Article] A Delicate Balance: CD73-generated adenosine limits the severity of graft vs. host disease, but also constrains the allogeneic graft vs. tumor effect2013
- Author(s)
  Thompson LF, Tsukamoto H, Chernogorova P, Zeiser R
- Journal Title
  
  OncoImmunology
  
  Volume: 2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790112
[Journal Article] Difucosylation of chitooligosaccharides by eukaryote and prokaryote alpha1,6-fucosyltransferases.2013
- Author(s)
  Ihara H, Hanashima S, Tsukamoto H, Yamaguchi Y, Taniguchi N, Ikeda Y
- Journal Title
  
  Biochim. Biophys. Acta
  
  Volume: 1830 Issue: 10 Pages: 4482-4490
- DOI
  10.1016/j.bbagen.2013.05.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550099, KAKENHI-PROJECT-24790112
[Journal Article] Reduced surface expression of TLR4 by a V254I point mutation accounts for the low lipopolysaccharide responder phenotype of BALB/c B cells.2013
- Author(s)
  Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Ohta S, Nagai Y, Ihara H, Miyake K, Ikeda Y, Kimoto M
- Journal Title
  
  J. Immunol.
  
  Volume: 190 Issue: 1 Pages: 195-204
- DOI
  10.4049/jimmunol.1201047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550099, KAKENHI-PROJECT-24590577, KAKENHI-PROJECT-24591466, KAKENHI-PROJECT-24790112
[Journal Article] MD-2-dependent human Toll-like receptor 4 monoclonal antibodies detect extracellular association of Toll-like receptor 4 with extrinsic soluble MD-2 on the cell surface.2013
- Author(s)
  Tsukamoto H, Ihara H, Ito R, Ukai I, Suzuki N, Kimoto M, Tomioka Y, Ikeda Y
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 440 Issue: 1 Pages: 31-36
- DOI
  10.1016/j.bbrc.2013.09.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550099, KAKENHI-PROJECT-24790112, KAKENHI-PROJECT-25430135
[Journal Article] An assay for alpha1,6-fucosyltransferase (FUT8) activity based on the HPLC separation of a reaction product with fluorescence detection.2013
- Author(s)
  Ihara H, Tsukamoto H, Taniguchi N, Ikeda Y
- Journal Title
  
  Methods Mol. Biol.
  
  Volume: 1022 Pages: 335-348
- DOI
  10.1007/978-1-62703-465-4_25
- ISBN
  9781627034647, 9781627034654
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550099, KAKENHI-PROJECT-24790112
[Journal Article] A Delicate Balance–CD73 generated adenosine limits the severity of graft vs. host disease, but also constrains the allogeneic graft vs. tumor effect2013
- Author(s)
  Thompson LF, Tsukamoto H, Chernogorova P, Zeiser R
- Journal Title
  
  OncoImmunology
  
  Volume: 2(1) Issue: 1 Pages: 22107-22107
- DOI
  10.4161/onci.22107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790112
[Journal Article] Multiple potential regulatory sites of TLR4 activation induced by LPS as revealed by novel inhibitory human TLR4 mAbs2012
- Author(s)
  Tsukamoto H, Fukudome K, Takao S, .
- Journal Title
  
  Int Immunol
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-21590538
[Journal Article] Measurement of Peroxiredoxin-4 in Rat Tissues and Implication of Its Serum Levels as a Potential Marker for Hepatic Disease.2012
- Author(s)
  Ritsu Ito
- Journal Title
  
  Mol Med Report
  
  Volume: 6 Issue: 2 Pages: 379-384
- DOI
  10.3892/mmr.2012.935
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590262, KAKENHI-PROJECT-23550099, KAKENHI-PROJECT-24790112
[Journal Article] Multiple potential regulatory sites of TLR4 activation induced by LPS as revealed by novel inhibitory human TLR4 mAbs.2012
- Author(s)
  Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Ihara H, Ikeda Y, Kimoto M
- Journal Title
  
  Int. Immunol.
  
  Volume: 24 Issue: 8 Pages: 495-506
- DOI
  10.1093/intimm/dxs053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550099, KAKENHI-PROJECT-24790112
[Journal Article] Deficiency of CD73/ecto-5'-nucleotidase in mice enhances acute graft-versus-host disease2012
- Author(s)
  Tsukamoto H, Chernogorova P, Ayata K, Gerlach UV, Rughani A, Ritchey JW, Ganesan J, Follo M, Zeiser R, Thompson LF, Idzko M
- Journal Title
  
  Blood
  
  Volume: 119(19) Issue: 19 Pages: 4554-4564
- DOI
  10.1182/blood-2011-09-375899
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790112
[Journal Article] Multiple potential regulatory sites of TLR4 activation induced by LPS as revealed by novel inhibitory human TLR4 mAbs2012
- Author(s)
  Tsukamoto H
- Journal Title
  
  Int Immunol
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590538
[Journal Article] Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells.2010
- Author(s)
  Tsukamoto H
- Journal Title
  
  Int Immunol.
  
  Volume: 22(4) Pages: 271-280
- NAID
  10027392279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590538
[Journal Article] Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells2010
- Author(s)
  Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Kimoto M.
- Journal Title
  
  Int Immunol
  
  Volume: 22(4) Pages: 271-80
- NAID
  10027392279
- Data Source
  KAKENHI-PROJECT-21590538
[Journal Article] TEX101, a Germ Cell-Marker Glycoprotein, is Associated with Lymphocyte Antigen 6 Complex Locusk within the Mouse Testis Biochem2008
- Author(s)
  Hiroshi Yoshitake, Hiroki Tsukamoto, Mayuko Maruyama-Fukushima, Kenji Takamori, Hideoki Ogawa, Yoshihiko Araki
- Journal Title
  
  Biophys. Res. Commun 372(2)
  
  Pages: 277-282
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790093
[Journal Article] Genomic organization and structure of the 5'-flanking region of the TEX101 gene: Alternative promoter usage and splicinggenerate transcript variants with distinct 5'-untranslated region.2007
- Author(s)
  Tsukamoto H
- Journal Title
  
  Mol Reprod Dev. 74(2)
  
  Pages: 154-162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790093
[Journal Article] Genomic organization and structure of the 5-flanking region of the TEX101 gene : Alternative promoter usage and splicing generate transcript variants with distinct 5'-untranslated region.2007
- Author(s)
  Tsukamoto H
- Journal Title
  
  Mol Rep rod Dev. 74(2)
  
  Pages: 154-162
- Data Source
  KAKENHI-PROJECT-18890140
[Journal Article] Preparation and Characterization of Agonistic Monoclonal Antibodies Against Toll-Like Receptor 4-MD-2 Complex2007
- Author(s)
  Bahrun U, Kimoto M, Tsukamoto H, Tsuneyoshi N, Kohara J, Fukudome K
- Journal Title
  
  Hybridoma 26
  
  Pages: 393-399
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790093
[Journal Article] Preparation of recombinant murine tumor necrosis factor-alpha in Escherichia coli : a rapid method to remove tags from fusion proteins by thrombin-cleavage and ion-exchange chromatography2007
- Author(s)
  Tsukamoto H, Fukudome K, Kohara J, Nakatake H, Kimoto M
- Journal Title
  
  Protein Expr Purif 56(1)
  
  Pages: 138-44
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790093
[Journal Article] Genomic organization and structure of the 5'-flanking region of the TEX101 gene : Alternative promoter usage and splicing generate transcript variants with distinct 5'-untranslated region2007
- Author(s)
  Tsukamoto H, Takizawa T, Takamori K, Ogawa H, Araki Y
- Journal Title
  
  Mol Reprod Dev 74(2)
  
  Pages: 154-162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790093
[Journal Article] Testicular proteins associated with the germ celトmarker, TEX101 : Involvement of cellubrevin in TEX101-trafficking to the cell surface during spermatogenesis.2006
- Author(s)
  Tsukamoto H
- Journal Title
  
  Biochem Biophys Res Commun 345
  
  Pages: 229-238
- Data Source
  KAKENHI-PROJECT-18890140
[Patent] 炎症治療用医薬組成物2012
- Inventor(s)
  木本雅夫、塚本宏樹、福留健司、常吉直子
- Industrial Property Rights Holder
  佐賀大学
- Industrial Property Rights Type
  特許
- Filing Date
  2012-06-15
- Data Source
  KAKENHI-PROJECT-24790112
[Patent] 炎症治療用医薬組成物2012
- Inventor(s)
  木本雅夫、塚本宏樹、福留健司、常吉直子
- Industrial Property Rights Holder
  佐賀大学
- Industrial Property Rights Type
  特許
- Filing Date
  2012-06-15
- Data Source
  KAKENHI-PROJECT-24790112
[Presentation] Toll様受容体4刺激抗体は食物アレルギーを予防、抑制する2023
- Author(s)
  塚本宏樹、小林洋平、渡邉悠理香、渡邊康一、富岡佳久
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06532
[Presentation] Toll様受容体4刺激抗体は肥満細胞の炎症反応を抑制する2023
- Author(s)
  塚本宏樹、小林洋平、渡邉悠理香、富岡佳久
- Organizer
  第40回日本薬学会九州山口支部大会
- Data Source
  KAKENHI-PROJECT-21K06532
[Presentation] 糖尿病性腎臓病評価法に用いる蛍光標識フェニルサルフェートの合成2023
- Author(s)
  熊谷知大、小田垣水晶、秋山泰利、松本洋太郎、塚本宏樹、金光祥臣、富岡佳久
- Organizer
  第62回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-21K06532
[Presentation] 食物アレルギーを抑制するToll様受容体4刺激抗体の肥満細胞抑制作用2023
- Author(s)
  塚本宏樹
- Organizer
  第13回国際医療福祉大学学会学術大会
- Data Source
  KAKENHI-PROJECT-21K06532
[Presentation] Toll様受容体4刺激抗体の食物アレルギー予防・治療効果2022
- Author(s)
  塚本宏樹、小林洋平、渡邉悠理香、富岡佳久
- Organizer
  第39回日本薬学会九州山口支部大会
- Data Source
  KAKENHI-PROJECT-21K06532
[Presentation] 根治を目指すToll様受容体4刺激抗体による食物アレルギー予防・治療戦略2022
- Author(s)
  塚本宏樹
- Organizer
  第12回国際医療福祉大学学会学術大会
- Data Source
  KAKENHI-PROJECT-21K06532
[Presentation] ヒトToll様受容体4を抑制する低分子組換え抗体の発現と機能評価2021
- Author(s)
  塚本宏樹、鵜飼一歩、山形由貴、武内偲乃、富岡佳久
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06532
[Presentation] 不活性型二量体構造の誘導によるヒトToll様受容体4抑制機序の解明と創薬への応用2021
- Author(s)
  塚本宏樹
- Organizer
  第11回国際医療福祉大学学会学術大会
- Data Source
  KAKENHI-PROJECT-21K06532
[Presentation] Toll 様受容体4 刺激抗体の肥満細胞抑制作用2020
- Author(s)
  渡邉悠理香、塚本宏樹、小林洋平、富岡佳久
- Organizer
  第59回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-18K06651
[Presentation] ヒトperoxiredoxin 4モノクローナル抗体の作製とエピトープ解析2020
- Author(s)
  塚本宏樹、紫竹歩、後藤裕徳、小坂井沙緒、富岡佳久、池田義孝
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K06651
[Presentation] 安定同位体内標準物質を用いた修飾核酸一斉定量系の構築2020
- Author(s)
  平本航大、渡辺匠、松本洋太郎、塚本宏樹、富岡佳久
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19H03509
[Presentation] 安定同位体内標準物質を用いた修飾核酸一斉定量系の構築2020
- Author(s)
  平本航大、渡辺匠、松本洋太郎、塚本宏樹、富岡佳久
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K06651
[Presentation] Toll様受容体4刺激抗体によるアレルギー性接触皮膚炎抑制効果2019
- Author(s)
  紫竹歩、塚本宏樹、渡邊康一、野地智法、麻生久、富岡佳久
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K06651
[Presentation] CKD評価法に用いる蛍光標識フェニルサルフェートの合成2019
- Author(s)
  中村隆太郎、松本洋太郎、塚本宏樹、金光祥臣、富岡佳久
- Organizer
  第58回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-19H03509
[Presentation] Peroxiredoxin 4は臨床的放射線耐性口腔扁平上皮癌細胞の耐性能に寄与する2019
- Author(s)
  後藤裕徳、金光祥臣、桑原義和、福本学、塚本宏樹、富岡佳久
- Organizer
  第58回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-18K06651
[Presentation] CKD評価法に用いる蛍光標識フェニルサルフェートの合成2019
- Author(s)
  中村隆太郎、松本洋太郎、塚本宏樹、金光祥臣、富岡佳久
- Organizer
  第58回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-18K06651
[Presentation] Peroxiredoxin 4は臨床的放射線耐性口腔扁平上皮癌細胞の耐性能に寄与する2019
- Author(s)
  後藤裕徳、金光祥臣、桑原義和、福本学、塚本宏樹、富岡佳久
- Organizer
  第58回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-19H03509
[Presentation] 修飾核酸の高精度一斉定量系の構築2018
- Author(s)
  平本航大、松本洋太郎、塚本宏樹、富岡佳久
- Organizer
  第57回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-18K06651
[Presentation] Toll 様受容体4(TLR4)刺激抗体によるがん免疫療法の開発2018
- Author(s)
  塚本宏樹、久保田佳苗、富岡佳久
- Organizer
  日本薬学会　医療薬学フォーラム2018
- Data Source
  KAKENHI-PROJECT-16H04704
[Presentation] Toll 様受容体4 による樹状細胞の抗原取込とT 細胞抗原特異的免疫応答の抑制2018
- Author(s)
  髙梨理紗子、小坂井沙緒、塚本宏樹、富岡佳久
- Organizer
  第57回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-18K06651
[Presentation] 多層オミクス手法による放射線耐性化関連分子の探索2018
- Author(s)
  富岡佳久、金光祥臣、松本洋太郎、桑原義和、福本　学、塚本宏樹
- Organizer
  第3回治療耐性がん細胞研究協議会セミナー
- Data Source
  KAKENHI-PROJECT-16K20909
[Presentation] Toll様受容体4刺激抗体による抗腫瘍T細胞誘導を介したがん免疫療法2018
- Author(s)
  塚本宏樹、久保田佳苗、富岡佳久
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16H04704
[Presentation] Toll様受容体4刺激抗体による抗腫瘍T細胞誘導を介したがん免疫療法2018
- Author(s)
  塚本宏樹、久保田佳苗、富岡佳久
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K06651
[Presentation] 修飾核酸の高精度一斉定量系の構築2018
- Author(s)
  平本航大、松本洋太郎、塚本宏樹、富岡佳久
- Organizer
  日本薬学会　第57回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-16H04704
[Presentation] 異なるシグナル誘導活性を持つToll様受容体4刺激抗体による抗原特異的抗体産生抑制効果2017
- Author(s)
  小林洋平、小坂井沙緖、久保田佳苗、武内偲乃、金光祥臣、松本洋太郎、塚本宏樹、富岡佳久
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台市（仙台国際センター・東北大学）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-26460058
[Presentation] ヒトToll様受容体4活性化に必要なleucine-rich repeat 13は抑制抗体によって認識される2017
- Author(s)
  山形由貴、大久保美咲、鵜飼一歩、金光祥臣、松本洋太郎、塚本宏樹、富岡佳久
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台市（仙台国際センター・東北大学）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-26460058
[Presentation] LC-MSを用いた細胞内サイクリックADPリボース高感度定量法の構築2017
- Author(s)
  齋藤一樹、金光祥臣、田中晃佑、鈴木千登世、阿部高明、塚本宏樹、松本洋太郎、富岡佳久
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台市（仙台国際センター・東北大学）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-26460058
[Presentation] ミックスドモード ODS カラムを用いた LC-MS/MS による尿毒症物質一斉定量系の構築2017
- Author(s)
  金光祥臣、淺地圭、松本洋太郎、塚本宏樹、三枝大輔、阿部高明、富岡佳久
- Organizer
  第56回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-16K20909
[Presentation] サイクリックADP リボース安定同位体の合成2017
- Author(s)
  齋藤一樹、田中晃佑、鈴木千登世、阿部高明、金光祥臣、塚本宏樹、松本洋太郎、富岡佳久
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台市（仙台国際センター・東北大学）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-26460058
[Presentation] 不活性型二量体構造の誘導を介した抑制型ヒトToll様受容体4抗体の新規作用機序2017
- Author(s)
  山形由貴、鵜飼一歩、金光祥臣、小林洋平、松本洋太郎、塚本宏樹、富岡佳久
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台市（仙台国際センター・東北大学）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-26460058
[Presentation] LPS-binding proteinはToll様受容体4の二量体化・内在化を介してTRIF依存的IKKε/TBK1/IRF3経路を活性化する2017
- Author(s)
  久保田佳苗、武内偲乃、鵜飼一歩、小坂井沙緒、金光祥臣、松本洋太郎、塚本宏樹、富岡佳久
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台市（仙台国際センター・東北大学）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-26460058
[Presentation] Toll様受容体4シグナルによるGr1+CD11b+細胞誘導を介した抗原特異的抗体産生抑制機序2017
- Author(s)
  小坂井沙緒、小林洋平、金光祥臣、松本洋太郎、塚本宏樹、富岡佳久
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台市（仙台国際センター・東北大学）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-26460058
[Presentation] LC-HDMS および IMS を用いたヒト肝癌組織メタボロミクスによる新規バイオマーカーの同定2017
- Author(s)
  永井滉士、三枝大輔、山崎貴広、金光祥臣、塚本宏樹、池田均、矢冨裕、松本洋太郎、富岡佳久
- Organizer
  第56回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-16K20909
[Presentation] LC-MSを用いた高感度サイクリックADPリボース定量法の構築2016
- Author(s)
  齋藤一樹、金光祥臣、松本洋太郎、塚本宏樹、鈴木千登世、阿部高明、富岡佳久
- Organizer
  第55回日本薬学会東北支部大会
- Place of Presentation
  郡山市（奥羽大学）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-26460058
[Presentation] イナビルによるアナフィラキシー症例報告と添加乳糖に夾雑するアレルゲン乳タンパク質の同定2016
- Author(s)
  金光祥臣、森川みき、塚本宏樹、松本洋太郎、森川昭正、富岡佳久
- Organizer
  第26回日本医療薬学会年会
- Place of Presentation
  京都市（国立京都国際会館・グランドプリンスホテル京都）
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-26460058
[Presentation] LPS-binding proteinはリポ多糖によるToll様受容体4の内在化を誘導する2016
- Author(s)
  武内偲乃、久保田佳苗、小坂井沙緒、塚本宏樹、富岡佳久
- Organizer
  第55回日本薬学会東北支部大会
- Place of Presentation
  郡山市（奥羽大学）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-26460058
[Presentation] Simultaneous quantitative analysis of modified nucleosides by liquid chromatography-tandem mass spectrometry2015
- Author(s)
  Jinno D, Saitoh K, Nankumo S, Kanemitsu Y, Tsukamoto H, Matsumoto Y, Mishima E, Suzuki C, Abe T, Tomioka Y
- Organizer
  Pharmaceutical Science Symposium 2015 in Sendai
- Place of Presentation
  仙台（東北大学片平キャンパス））
- Year and Date
  2015-11-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460058
[Presentation] LC/MS/MSによる修飾核酸一斉定量法の構築と応用2015
- Author(s)
  陣野大輔、齋藤一樹、南雲信之介、金光祥臣、塚本宏樹、松本洋太郎、三島英換、鈴木千登世、阿部高明、富岡佳久
- Organizer
  第54回日本薬学会東北支部大会
- Place of Presentation
  岩手（岩手医科大学矢巾キャンパス）
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-26460058
[Presentation] リコカルコンAのCOX-1活性抑制メカニズムの解明2014
- Author(s)
  菅原大貴、田代匠、三枝大輔、塚本宏樹、奥田亜沙、小原祐太郎、鈴木直人、富岡佳久
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24790112
[Presentation] 抗1-methyladenosine抗体反応性分子の同定を目的としたtRNA分子種の解析法に関する研究2014
- Author(s)
  津久井佑梨、陣野大輔、三島英換、鈴木直人、塚本宏樹、三枝大輔、伊藤邦彦、阿部高明、富岡佳久
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Year and Date
  2014-03-28
- Data Source
  KAKENHI-PROJECT-24790112
[Presentation] シースレスインターフェイスを用いたCE-MSによる低分子化合物分析法の検討2014
- Author(s)
  陣野大輔、齋藤一樹、由利謙典、武川力永、塚本宏樹、鈴木直人、阿部高明、富岡佳久
- Organizer
  第53回日本薬学会東北支部大会
- Place of Presentation
  いわき
- Year and Date
  2014-10-05
- Data Source
  KAKENHI-PROJECT-26460058
[Presentation] 新規腎障害マーカーとしての1-メチルアデノシンの検討2013
- Author(s)
  陣野大輔、鈴木直人、津久井佑梨、三枝大輔、三島英換、鈴木千登世、塚本宏樹、阿部高明、富岡佳久
- Organizer
  第52回日本薬学会東北支部大会
- Place of Presentation
  仙台
- Year and Date
  2013-10-20
- Data Source
  KAKENHI-PROJECT-24790112
[Presentation] MD-2-dependent and lipopolysaccharide-induced conformation change-sensitive monoclonal antibodies detect extracellular association of human toll-like receptor 4 with soluble MD-2 on cell surface2013
- Author(s)
  Tsukamoto H, Ukai I, Kimoto M
- Organizer
  第42回日本免疫学会総会・学術集会
- Place of Presentation
  幕張メッセ（千葉）
- Data Source
  KAKENHI-PROJECT-24790112
[Presentation] LC/ESI‐MSを用いた血清胸腺因子(FTS)定量法の開発2013
- Author(s)
  中曽根正皓、鈴木直人、金光祥臣、塚本宏樹、富岡佳久
- Organizer
  第52回日本薬学会東北支部大会
- Place of Presentation
  仙台
- Year and Date
  2013-10-20
- Data Source
  KAKENHI-PROJECT-24790112
[Presentation] MD-2-dependent and lipopolysaccharide-induced conformation change-sensitive monoclonal antibodies detect extracellular association of human toll-like receptor 4 with soluble MD-2 on cell surface2013
- Author(s)
  Tsukamoto H, Ukai I, Kimoto M
- Organizer
  第42回日本免疫学会総会・学術集会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-24790112
[Presentation] Enzymatic synthesis of di-fucosylated chitooligosaccharide by human and rhizobia α1,6-fucosyltransferases2012
- Author(s)
  Ihara H, Hanashima S, Tsukamoto H, Yamaguchi Y, Taniguchi N, Ikeda Y
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24790112
[Presentation] Enzymatic synthesis of di-fucosylated chitooligosaccharide by human and rhizobiaα1,6-fucosyltransferases2012
- Author(s)
  Ihara H, Hanashima S, Tsukamoto H, Yamaguchi Y, Taniguchi N, Ikeda Y
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24790112
[Presentation] Reduced surface expression of TLR4 by a V254I point mutation may account for the low LPS responder phenotype of BALB/c B cells2012
- Author(s)
  Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Ohta S, Nagai Y, Ihara H, Miyake K, Ikeda Y, Kimoto M
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24790112
[Presentation] Inhibition of antibody production in vivo by pre-injection of agonistic anti-TLR4/MD-2 monoclonal antibody before antigen priming is caused not by impairment in antigen presentation but by defective B cell priming2012
- Author(s)
  Rachmawati NM, Fukudome K, Tsuneyoshi N, Bahrun U, Tsukamoto H, Ohta S, Kimoto M
- Organizer
  第41回日本免疫学会総会・学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24790112
[Presentation] Lipopolysaccharide-bindingprotein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells2010
- Author(s)
  Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Kimoto M.
- Organizer
  第14回国際免疫学会議
- Year and Date
  2010-08-27
- Data Source
  KAKENHI-PROJECT-21590538
[Presentation] Lipopolysaccharide-bindingprotein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells.2010
- Author(s)
  Tsukamoto H
- Organizer
  第14回国際免疫学会議
- Place of Presentation
  神戸市
- Year and Date
  2010-08-27
- Data Source
  KAKENHI-PROJECT-21590538
[Presentation] Anti- human TLR4 monoclonal antibody which specifically prevents the LPS responses independently of Fc receptors2008
- Author(s)
  Tsukamoto H
- Organizer
  第38回日本免疫学会総会
- Place of Presentation
  京都市
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-19790093
[Presentation] 機能抑制型ヒトTLR4抗体Anti-human TLR4 monoclonal antibody which specifically prevents the LPS responses independently of Fc receptors2008
- Author(s)
  Tsukamoto H, Kimoto M, Tsuneyoshi N, Fukudome K
- Organizer
  第38回日本免疫学会総会
- Place of Presentation
  日本免疫学会会誌38:169
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-19790093
[Presentation] Oligomerization-independent TLR4-signaling in CD14-negative cells2007
- Author(s)
  Tsukamoto H, Kohara J, Tsuneyoshi N, Kimoto M, Fukudome K
- Organizer
  第37回日本免疫学会総会
- Place of Presentation
  日本免疫学会会誌37:163
- Year and Date
  2007-11-21
- Data Source
  KAKENHI-PROJECT-19790093
[Presentation] Oligomerization-independent TLR4-signaling in CD14-negative cells.2007
- Author(s)
  Tsukamoto H
- Organizer
  第37回日本免疫学会総会
- Place of Presentation
  東京
- Year and Date
  2007-11-21
- Data Source
  KAKENHI-PROJECT-19790093
[Presentation] Adjuvant effects of agonistic anti-TLR4 monoclonal antibody in antibody induction2007
- Author(s)
  Fukudome K, Kohara J, Tsukamoto H,Tsuneyoshi N, Kimoto M
- Organizer
  第37回日本免疫学会総会
- Place of Presentation
  日本免疫学会会誌37:227
- Year and Date
  2007-11-22
- Data Source
  KAKENHI-PROJECT-19790093
[Presentation] 機能性Toll様受容体4抗体による敗血症治療と病態解析への応用（シンポジスト）
- Author(s)
  塚本宏樹、富岡佳久
- Organizer
  第16回応用薬理シンポジウム
- Place of Presentation
  松島
- Year and Date
  2014-12-04 – 2014-12-05
- Data Source
  KAKENHI-PROJECT-26460058
[Presentation] Graft‐versus‐host diseaseにおけるCD73と細胞外アデノシンの役割
- Author(s)
  塚本宏樹
- Organizer
  第12回医療薬学若手研究者セミナーシンポジスト
- Place of Presentation
  東北大学（仙台）
- Invited
- Data Source
  KAKENHI-PROJECT-24790112
[Presentation] 新規腎障害マーカーとしての1-メチルアデノシンの検討
- Author(s)
  陣野大輔、鈴木直人、津久井佑梨、三枝大輔、三島英換、鈴木千登世、塚本宏樹、阿部高明、富岡佳久
- Organizer
  第52回日本薬学会東北支部大会
- Place of Presentation
  東北大学（仙台）
- Data Source
  KAKENHI-PROJECT-24790112
[Presentation] 新規ヒトTLR4モノクローナル抑制抗体のエピトープ解析
- Author(s)
  鵜飼一歩、塚本宏樹、山形由貴、鈴木直人、富岡佳久
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26460058
[Presentation] CD14のLPS結合能とTLR4内在化の機能連関
- Author(s)
  武内偲乃、塚本宏樹、鵜飼一歩、山形由貴、久保田佳苗、小坂井沙緒、富岡佳久
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26460058
[Presentation] LC/ESI‐MS を用いた血清胸腺因子(FTS)定量法の開発
- Author(s)
  中曽根正皓、鈴木直人、金光祥臣、塚本宏樹、富岡佳久
- Organizer
  第52回日本薬学会東北支部大会
- Place of Presentation
  東北大学（仙台）
- Data Source
  KAKENHI-PROJECT-24790112
[Presentation] 機能抑制型抗ヒトTLR4モノクローナル抗体は不活性型TLR4二量体構造を誘導する
- Author(s)
  山形由貴、塚本宏樹、鵜飼一歩、鈴木直人、富岡佳久
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26460058
[Presentation] 移植片対宿主病と移植片対腫瘍効果における細胞外アデノシン産生系の機能解析とその薬学的制御に関する研究
- Author(s)
  塚本宏樹
- Organizer
  東北薬学セミナー奨励賞受賞講演
- Place of Presentation
  東北薬科大学（仙台）
- Invited
- Data Source
  KAKENHI-PROJECT-24790112
[Presentation] A validated quantitative LC-MS/MS method using isotopic MRM transitions to evaluate global ratios of modified cytosines
- Author(s)
  Tsuji M, Matsunaga H, Jinno D, Tsukamoto H, Suzuki N, Tomioka Y
- Organizer
  20th International Mass Spectrometry Conference (IMSC 2014)
- Place of Presentation
  Geneva, Switzerland
- Year and Date
  2014-08-24 – 2014-08-29
- Data Source
  KAKENHI-PROJECT-26460058
[]
[]
[]

1. TOMIOKA Yoshihisa (00282062)

# of Collaborated Projects: 4 results

# of Collaborated Products: 32 results
2. MATSUMOTO Yotato (90420041)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
3. KIMOTO Masao (40153225)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. FUKUDOME Kenji (50284625)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. Kanemitsu Yoshitomi (30752943)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. FUKUMOTO Manabu (60156809)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. KUWAHARA Yoshikazu (00392225)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 秋山泰利 (70635557)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. NUMASAKI Muneo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. IHARA Hideyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
11. 太田昭一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 鄭文玉

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
13. 福田真嗣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 西岡安彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 山崎聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TSUKAMOTO HIROKI 塚本 宏樹

TSUKAMOTO Hiroki 塚本 宏樹

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Co-Researchers

低分子免疫チェックポイント阻害化合物による複合がん免疫療法の創薬基盤研究Principal Investigator

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TLR4刺激抗体の食物アレルギー抑制機序解明による新規アレルギー予防・治療戦略Principal Investigator

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Search for molecules that control the CD39-CD73-adenosine cascade and expand into drug discovery

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Combination cancer immunotherapy with antigen-specific agonistic TLR4 antibody and immune checkpoint inhibitorsPrincipal Investigator

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Investigation of the modified nucleic acid for novel cancer evaluation marker candidates and its diagnostic application.

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Elucidation of the mechanism of radioresistance in cancer cells using trans-omics approach and development of clinical biomarkers for radiotherapy.

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A novel immunotherapy of autoimmune disease by agonistic toll-like receptor 4 antibodyPrincipal Investigator

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Novel regulatory mechanism of human Toll-like receptor 4 function by the inhibitory monoclonal antibodyPrincipal Investigator

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Aanalysis of immune activation and protective mechanisms against infection using agonistic anti-TLR4 mAb

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Recognition of lipopolysaccharide by adiponectinPrincipal Investigator

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刺激型抗TLR抗体による新しい癌の治療法の理論構築と創薬開発への応用Principal Investigator

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[Book] Bioactive Lipid Mediators-Current Reviews and Protocols2015

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[Book] Handbook of Glycosyltransferases and Related Genes, 2nd ed2014

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TSUKAMOTO HIROKI 塚本宏樹

TSUKAMOTO Hiroki 塚本宏樹