Boone Charles ＢＯＯＮＥＣＨＡＲＬＥＳ

Researcher Number	70601342
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 環境資源科学研究センター, チームディレクター
Affiliation (based on the past Project Information) *help	2015 – 2025: 国立研究開発法人理化学研究所, 環境資源科学研究センター, チームリーダー
Review Section/Research Field	Principal Investigator Basic Section 37030:Chemical biology-related / Science and Engineering / Applied microbiology Except Principal Investigator Science and Engineering
Keywords	Principal Investigator target identification / yeast / chemical genomics / chemical genetics / Chemical genomics / CRISPR-Cas9 / Chemical genetics / Target identification / HAP1 / CRISPR / chemical communication / morphological profiling … More Except Principal Investigator … More 生物活性リガンド / ケミカルバイオロジー / 天然物化学 / 分子社会学 / 化学コミュニケーション Less

A fission yeast chemical-genomics platform for systematic functional annotation of novel bioactive compoundsPrincipal Investigator
- Principal Investigator
  
  BOONE CHARLES
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Institute of Physical and Chemical Research
Target identification with systematic CRISPR-based chemical-genetic profiling in human HAP1 cellsPrincipal Investigator
- Principal Investigator
  
  BOONE CHARLES
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Institute of Physical and Chemical Research
A chemical genomics approach for understanding chemical communicationPrincipal Investigator
- Principal Investigator
  
  Boone Charles
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Institute of Physical and Chemical Research
Frontiers in Chemical Communications
- Principal Investigator
  
  Kakeya Hideaki
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Kyoto University
Linking novel bioactive compounds to their targets and pathways using chemical genomics and morphological profilingPrincipal Investigator
- Principal Investigator
  
  Boone Charles
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied microbiology
- Research Institution
  Institute of Physical and Chemical Research

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Patent

[Journal Article] The proteomic landscape of genome-wide genetic perturbations.2023
- Author(s)
  Messner CB, Demichev V, Muenzner J, Aulakh SK, Barthel N, Rohl A, Herrera-Dominguez L, Egger AS, Kamrad S, Hou J, Tan G, Lemke O, Calvani E, Szyrwiel L, Mulleder M, Lilley KS, Boone C, Kustatscher G, Ralser M.
- Journal Title
  
  Cell Chem. Biol.
  
  Volume: 186 Issue: 9 Pages: 2018-2034.e21
- DOI
  10.1016/j.cell.2023.03.026
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23491
[Journal Article] Overexpression profiling reveals cellular requirements in the context of genetic backgrounds and environments2023
- Author(s)
  Saeki Nozomu、Yamamoto Chie、Eguchi Yuichi、Sekito Takayuki、Shigenobu Shuji、Yoshimura Mami、Yashiroda Yoko、Boone Charles、Moriya Hisao
- Journal Title
  
  PLOS Genetics
  
  Volume: 19 Issue: 4 Pages: e1010732-e1010732
- DOI
  10.1371/journal.pgen.1010732
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21J12451, KAKENHI-PROJECT-22K19294, KAKENHI-PROJECT-21K05507, KAKENHI-PLANNED-23H04882, KAKENHI-PROJECT-20H03242, KAKENHI-PROJECT-23K23491
[Journal Article] Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity2023
- Author(s)
  K. R. Iyer, S. C. Li, N. M. Revie, J. W. Lou, D. Duncan, S. Fallah, H. Sanchez, I. Skulska, M. M. U_aj, H. Safizadeh, B. Larsen, C. Wong, A. Aman, T. Kiyota, M. Yoshimura, H. Kimura, H. Hirano, M. Yoshida,... Y. Yashiroda, C. Boone, L. E. Cowen
- Journal Title
  
  Cell Chem. Biol.
  
  Volume: 30 Issue: 7 Pages: 795-810
- DOI
  10.1016/j.chembiol.2023.06.005
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23H04882, KAKENHI-PROJECT-23H05473, KAKENHI-PROJECT-21H04720, KAKENHI-PROJECT-23K23491
[Journal Article] N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity.2023
- Author(s)
  Varland S, Silva RD, Kjosas I, Faustino A, Bogaert A, Billmann M, Boukhatmi H, Kellen B, Costanzo M, Drazic A, Osberg C, Chan K, Zhang X, Tong AHY, Andreazza S, Lee JJ, Nedyalkova L, Usaj M, Whitworth AJ, Andrews BJ, Moffat J, Myers CL, Gevaert K, Boone C, Martinho RG, Arnesen T.
- Journal Title
  
  Nat. Commun.
  
  Volume: 14 Issue: 1 Pages: 6774-6774
- DOI
  10.1038/s41467-023-42342-y
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23491
[Journal Article] BIONIC: Biological Network Integration Using Convolutions2022
- Author(s)
  Duncan T. Forster, Sheena C. Li, Yoko Yashiroda, Mami Yoshimura, Zhijian Li, Luis Alberto Vega Isuhuaylas, Kaori Itto-Nakama, Daisuke Yamanaka, Yoshikazu Ohya, Hiroyuki Osada, Bo Wang, Gary D. Bader & Charles Boone
- Journal Title
  
  Nature Methods
  
  Volume: 19 Issue: 10 Pages: 1250-1261
- DOI
  10.1038/s41592-022-01616-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07487, KAKENHI-PROJECT-23K23491, KAKENHI-PROJECT-23K23483
[Journal Article] Jerveratrum-Type Steroidal Alkaloids Inhibit β-1,6-Glucan Biosynthesis in Fungal Cell Walls2022
- Author(s)
  Kubo Karen、Itto-Nakama Kaori、Ohnuki Shinsuke、Yashiroda Yoko、Li Sheena C.、Kimura Hiromi、Kawamura Yumi、Shimamoto Yasuhiro、Tominaga Ken-Ichi、Yamanaka Daisuke、Adachi Yoshiyuki、Takashima Shinichiro、Noda Yoichi、Boone Charles、Ohya Yoshikazu
- Journal Title
  
  Microbiology Spectrum
  
  Volume: 10 Issue: 1
- DOI
  10.1128/spectrum.00873-21
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05764, KAKENHI-PLANNED-17H06411, KAKENHI-PROJECT-20K06584, KAKENHI-PROJECT-20K07487, KAKENHI-PROJECT-23K23483
[Journal Article] High-throughput platform for yeast morphological profiling predicts the targets of bioactive compounds2022
- Author(s)
  Ohnuki, S., Ogawa, I., Itto-Nakama, K., Lu, F., Ranjan, A., Kabbage, M., Gebre, AA., Yamashita, M., Li, SC., Yashiroda, Y., Yoshida, S., Usui, T., Piotrowski, JS., Andrews, BJ., Boone, C., Brown, GW., Ralph, J., Ohya, Y.
- Journal Title
  
  npj Systems Biology and Applications
  
  Volume: 8 Issue: 1 Pages: 3-3
- DOI
  10.1038/s41540-022-00212-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06411, KAKENHI-PROJECT-20K06584, KAKENHI-PROJECT-23K23483
[Journal Article] Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets2021
- Author(s)
  Fu, C., Zhang, X., Veri, AO., Iyer, KR., Lash, E., Xue, A., Yan, H., Revie, NM., Wong, C., Lin, ZY., Polvi, EJ., Liston, SD., VanderSluis, B., Hou, J., Yashiroda, Y., Gingras, AC., Boone, C., O'Meara, TR., O'Meara, MJ., Noble, S., Robbins, N., Myers, CL., Cowen, LE.
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 6497-6497
- DOI
  10.1038/s41467-021-26850-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06411
[Journal Article] Clionamines stimulate autophagy, inhibit Mycobacterium tuberculosis survival in macrophages, and target Pik12021
- Author(s)
  Persaud, R., Li, SC., Chao, JD., Forestieri, R., Donohue, E., Balgi, AD., Zheng, X., Chao, JT., Yashiroda, Y., Yoshimura, M., Loewen, CJR., Gingras, AC., Boone, C., Av-Gay, Y., Roberge, M., Andersen, RJ.
- Journal Title
  
  Cell Chemical Biology
  
  Volume: - Issue: 5 Pages: 870-882
- DOI
  10.1016/j.chembiol.2021.07.017
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06411, KAKENHI-PROJECT-23K23491
[Journal Article] Genome-wide Screening of Genes Associated with Momilactone B Sensitivity in the Fission Yeast2021
- Author(s)
  Keisuke Tomita, Yoko Yashiroda, Yasuhiro Matsuo, Jeff S Piotrowski, Sheena C Li, Reika Okamoto, Mami Yoshimura, Hiromi Kimura, Yumi Kawamura, Makoto Kawamukai, Charles Boone, Minoru Yoshida, Hideaki Nojiri, Kazunori Okada
- Journal Title
  
  G3 (Bethesda)
  
  Volume: 11 Issue: 8
- DOI
  10.1093/g3journal/jkab156
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19J14746, KAKENHI-PLANNED-17H06411, KAKENHI-PROJECT-19H05640, KAKENHI-PROJECT-20H02922, KAKENHI-PROJECT-21H02117
[Journal Article] Improving measures of chemical structural similarity using machine learning on chemical-genetic interactions2021
- Author(s)
  Safizadeh, H., Simpkins, SW., Nelson, J., Li, SC., Piotrowski, JS., Yoshimura, M., Yashiroda, Y., Hirano, H., Osada, H., Yoshida, M., Boone, C., Myers, CL.
- Journal Title
  
  Journal of Chemical Information and Modeling
  
  Volume: 61 Issue: 9 Pages: 4156-4172
- DOI
  10.1021/acs.jcim.0c00993
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06411, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-19H05640, KAKENHI-PLANNED-17H06412
[Journal Article] Environmental robustness of the global yeast genetic interaction network2021
- Author(s)
  Costanzo, M., Hou. J., Messier, V., Nelson, J., Rahman, M., VanderSluis, B., Wang, W., Pons, C., Ross, C., Usaj, M., San Luis, BJ., Shuteriqi, E., Koch, EN., Aloy, P., Myers, CL., Boone, C., Andrews, B.
- Journal Title
  
  Science
  
  Volume: 372 Issue: 6542
- DOI
  10.1126/science.abf8424
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06411
[Journal Article] A genome-scale yeast library with inducible expression of individual genes2021
- Author(s)
  Arita, Y., Kim, G., Li, Z., Friesen, H., Turco, G., Wang, RY., Climie, D., Usaj, M., Hotz, M., Stoops, EH., Baryshnikova, A., Boone, C., Botstein, D., Andrews, BJ., McIsaac, RS.
- Journal Title
  
  Molecular Systems Biology
  
  Volume: 17 Issue: 6
- DOI
  10.15252/msb.202110207
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06411
[Journal Article] Systematic genetics and single-cell imaging reveal widespread morphological pleiotropy and cell-to-cell variability2020
- Author(s)
  Mattiazzi Usaj M, Sahin N, Friesen H, Pons C, Usaj M, Masinas MPD, Shuteriqi E, Shkurin A, Aloy P, Morris Q, Boone C, Andrews BJ.
- Journal Title
  
  Mol Syst Biol
  
  Volume: 16 Issue: 2
- DOI
  10.15252/msb.20199243
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06411
[Journal Article] Genetic profiling of protein burden and nuclear export overload.2020
- Author(s)
  Kintaka R, Makanae K, Namba S, Kato H, Kito K, Ohnuki S, Ohya Y, Andrews BJ, Boone C, Moriya H.
- Journal Title
  
  Elife
  
  Volume: 9
- DOI
  10.7554/elife.54080
- NAID
  120006941058
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06411, KAKENHI-PUBLICLY-20H04870, KAKENHI-PROJECT-18K06228, KAKENHI-PROJECT-18K19300, KAKENHI-PROJECT-19H03205
[Journal Article] Using BEAN-counter to quantify genetic interactions from multiplexed barcode sequencing experiments2019
- Author(s)
  Simpkins SW, Deshpande R, Nelson J, Li SC, Piotrowski JS, Ward HN, Yashiroda Y, Osada H, Yoshida M, Boone C, Myers CL
- Journal Title
  
  Nature Protocols
  
  Volume: 14 Issue: 2 Pages: 415-440
- DOI
  10.1038/s41596-018-0099-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06411, KAKENHI-PLANNED-17H06412, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-26221204
[Journal Article] Integrating yeast chemical genomics and mammalian cell pathway analysis2019
- Author(s)
  Zhou, FL., Li, SC., Zhu, Y., Guo, WJ., Shao, LJ., Nelson, J., Simpkins, S., Yang, DH., Liu, Q., Yashiroda, Y., Xu, JB., Fan, YY., Yue, JM., Yoshida, M., Xia, T., Myers, CL., Boone, C., Wang, MW.
- Journal Title
  
  Acta Pharmacol. Sin.
  
  Volume: 40 Issue: 9 Pages: 1245-1255
- DOI
  10.1038/s41401-019-0231-y
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06411, KAKENHI-PROJECT-26221204
[Journal Article] Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interactions2018
- Author(s)
  Simpkins SW, Nelson J, Deshpande R, Li SC, Piotrowski JS, Wilson EH, Gebre AA, Safizadeh H, Okamoto R, Yoshimura M, Costanzo M, Yashiroda Y, Ohya Y, Osada H, Yoshida M, Boone C, Myers CL
- Journal Title
  
  PLoS Computational Biology
  
  Volume: 14 Issue: 10 Pages: e1006532-e1006532
- DOI
  10.1371/journal.pcbi.1006532
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06411, KAKENHI-PLANNED-17H06412, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-26221204
[Journal Article] MOSAIC: a chemical-genetic interaction data repository and web resource for exploring chemical modes of action2018
- Author(s)
  Nelson J, Simpkins SW, Safizadeh H, Li SC, Piotrowski JS, Hirano H, Yashiroda Y, Osada H, Yoshida M, Boone C, Myers CL.
- Journal Title
  
  Bioinformatics
  
  Volume: 34 Issue: 7 Pages: 1251-1252
- DOI
  10.1093/bioinformatics/btx732
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06411, KAKENHI-PROJECT-15H04483, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-26221204
[Journal Article] Exploring genetic suppression interactions on a global scale2016
- Author(s)
  van Leeuwen J, Pons C, Mellor JC, Yamaguchi TN, Friesen H, ..., and Boone C.
- Journal Title
  
  Science
  
  Volume: 354 Issue: 6312
- DOI
  10.1126/science.aag0839
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04483
[Journal Article] A global genetic interaction network maps a wiring diagram of cellular function2016
- Author(s)
  Costanzo M, VanderSluis B, Koch EN, Baryshnikova A, Pons C, ..., and Boone C.
- Journal Title
  
  Science
  
  Volume: 353 Issue: 6306
- DOI
  10.1126/science.aaf1420
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04483
[Journal Article] Controlling microbial contamination during hydrolysis of AFEX-pretreated corn stover and switchgrass: effects on hydrolysate composition, microbial response and fermentation.2015
- Author(s)
  Serate J, Xie D, Pohlmann E, Donald C Jr, Shabani M, Hinchman L, Higbee A, Mcgee M, La Reau A, Klinger GE, Li S, Myers CL, Boone C, Bates DM, Cavalier D, Eilert D, Oates LG, Sanford G, Sato TK, Dale B, Landick R, Piotrowski J, Ong RG, Zhang Y.
- Journal Title
  
  Biotechnol Biofuels
  
  Volume: 8 Issue: 1 Pages: 180-180
- DOI
  10.1186/s13068-015-0356-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04483
[Journal Article] Plant-derived antifungal agent poacic acid targets β-1,3-glucan2015
- Author(s)
  Piotrowski JS, Okada H, Lu F, Li SC, Hinchman L, Ranjan A, Smith DL, Higbee AJ, Ulbrich A, Coon JJ, Deshpande R, Bukhman YV, McIlwain S, Ong IM, Myers CL, Boone C, Landick R, Ralph J, Kabbage M, Ohya Y
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 112 Issue: 12
- DOI
  10.1073/pnas.1410400112
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24370002, KAKENHI-PROJECT-15H04402, KAKENHI-PROJECT-15H04483
[Journal Article] Chemical genomic profiling via barcode sequencing to predict compound mode of action.2015
- Author(s)
  Piotrowski JS, Simpkins SW, Li SC, Deshpande R, McIlwain SJ, Ong IM, Myers CL, Boone C, Andersen RJ.
- Journal Title
  
  Methods Mol Biol
  
  Volume: 1263 Pages: 299-318
- DOI
  10.1007/978-1-4939-2269-7_23
- ISBN
  9781493922680, 9781493922697
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04483
[Patent] Compounds as antifungal agents, derivatives thereof and novel compounds2023
- Inventor(s)
  Oya, Yashiroda, Boone, et al.
- Industrial Property Rights Holder
  Oya, Yashiroda, Boone, et al.
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Overseas
- Data Source
  KAKENHI-PROJECT-23K23491
[Presentation] 分裂酵母Schizosaccharomyces pombeにおいてペンタデカン酸が誘導する脂肪毒性2024
- Author(s)
  星川陽次郎、代田夏帆、松山晃久、木村聡、Sheena LI 、八代田陽子、Charles BOONE、津川裕司、有田誠、吉田稔、西村慎一
- Organizer
  日本農芸化学会2024年度大会
- Data Source
  KAKENHI-PROJECT-23K23491
[Presentation] 抗真菌剤NPD2560の細胞内作用機序に関する研究2023
- Author(s)
  劉薇、関口宙暉、山中大輔、八代田陽子、Sheena Li 、Charles Boone 、一刀かおり、大矢禎一
- Organizer
  酵母遺伝学フォーラム第56回研究報告会
- Data Source
  KAKENHI-PROJECT-23K23491
[Presentation] Exogenous pentadecanoic acid perturbs the membrane lipid profile to generate the giant endoplasmic reticulum sheet2023
- Author(s)
  Hoshikawa Y, Matsuyama A, Li S, Yashiroda Y, Boone C, Tsugawa H, Arita M, Yoshida M, Nishimura S.
- Organizer
  The 11th International Fission Yeast Meeting (Pombe 2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23491
[Presentation] Identification of potential therapeutic lead compounds targeting serine-palmitoyltransferase2023
- Author(s)
  Pham L, Yoshimura M, Yashiroda Y, Li S, Usaj M, Burke RM, oshida M, Boone C.
- Organizer
  The 2023 Cold Spring Harbor Asia Conference, Yeast and Life Sciences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23491
[Presentation] 抗真菌剤ポアシジエンは細胞質鉄イオンの蓄積を引き起こす2023
- Author(s)
  趙天宇、小川樹、吉村麻美、八代田陽子、Charles Boone
- Organizer
  酵母遺伝学フォーラム第56回研究報告会
- Data Source
  KAKENHI-PROJECT-23K23491
[Presentation] Mapping genetic interaction networks in yeast and human cells2023
- Author(s)
  Boone CM.
- Organizer
  The 2023 Cold Spring Harbor Asia Conference, Yeast and Life Sciences
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23491
[Presentation] Mapping genetic and chemical-genetic networks in yeast2023
- Author(s)
  Boone CM.
- Organizer
  31st International Conference on Yeast Genetics and Molecular Biology (ICYGMB31)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23491
[Presentation] Mode-of-action analysis of inhibitors targeting ergosterol2023
- Author(s)
  Yashiroda Y, Yoshimura M, Usui M, Kimura H, Isuhuaylas LAV, Pham LTK, Niwa T, Takahashi I, Hosoya T, Ilies L, Yoshida M, Boone C.
- Organizer
  The 2023 Cold Spring Harbor Asia Conference, Yeast and Life Sciences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23491
[Presentation] S. pombeケミカルゲノミクス法を用いた海産環状グアニジンアルカロイド化合物の作用機序解明2022
- Author(s)
  八代田陽子、木村寛美、吉村麻美、野口峻太朗、Sheena Li、Luis A. Vega I.、河村優美、吉田稔、酒井隆一、Charles Boone
- Organizer
  酵母遺伝学フォーラム第55回研究報告会
- Data Source
  KAKENHI-PROJECT-23K23491
[Presentation] Mapping Genetic and Chemical Genetic Interaction Networks in Yeast and Human Cells2022
- Author(s)
  Boone C
- Organizer
  The 21st International Conference on Systems Biology (ICSB 2022)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23491
[Presentation] Mapping Genetic and Chemical Genetic Interaction Networks in Yeast and Human Cells2022
- Author(s)
  Boone C
- Organizer
  9th Congress of the Genetic Society of Slovenia
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23491
[Presentation] 酵母の増殖阻害活性を示す含ホウ素化合物の作用機序解析2022
- Author(s)
  八代田陽子、木村寛美、吉村麻美、臼井正哉、丹羽節、高橋一光、俣賀宣子、細谷孝充、Laurean Ilies、吉田稔、Charles Boone
- Organizer
  日本農芸化学会2022年度大会
- Data Source
  KAKENHI-PLANNED-17H06411
[Presentation] 奇数鎖脂肪酸による分裂酵母の脂質組成の攪乱および小胞体の形態異常2022
- Author(s)
  星川陽次郎、西村慎一、松山晃久、Sheena Li、八代田陽子、Charles Boone、津川裕司、有田誠、吉田稔
- Organizer
  日本農芸化学会2022年度大会
- Data Source
  KAKENHI-PLANNED-17H06411
[Presentation] Identifying the targets of novel compounds using high throughput chemical-genomics screening2022
- Author(s)
  Lien Pham, Sheena Li, Luis Alberto Vega Isuhuaylas, Hamid Safizadeh, Yoko Yashiroda, Mami Yoshimura, Hiromi Kimura, Yumi Kawamura, Minoru Yoshida, Chad Myers, and Charles Boone
- Organizer
  酵母遺伝学フォーラム第55回研究報告会
- Data Source
  KAKENHI-PROJECT-23K23491
[Presentation] Mapping Genetic Interaction Networks in Yeast and Human Cells2022
- Author(s)
  Boone C
- Organizer
  British Yeast Group 2022: From Genomes to Cells
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23491
[Presentation] 奇数鎖脂肪酸による分裂酵母の脂質代謝攪乱と細胞分裂阻害2021
- Author(s)
  星川陽次郎、西村慎一、松山晃久、Sheena Li、八代田陽子、Charles Boone、津川裕司、有田誠、吉田稔
- Organizer
  第63回日本脂質生化学会
- Data Source
  KAKENHI-PLANNED-17H06411
[Presentation] 奇数鎖脂肪酸は分裂酵母において細胞膜極性と細胞分裂に異常を引き起こす2021
- Author(s)
  星川陽次郎、西村慎一、松山晃久、Li Sheena、八代田陽子、Boone Charles、吉田稔
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PLANNED-17H06411
[Presentation] Genetic Network Analysis of the NGLY1 Pathway2020
- Author(s)
  Charles Boone
- Organizer
  International Symposium on Glyco-lipidologue
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06411
[Presentation] Target identification using a yeast chemical genomic approach2019
- Author(s)
  Yoko Yashiroda, Sheena Li, Hiroyuki Osada, Minoru Yoshida, Chad Myers, Charles Boone
- Organizer
  酵母遺伝学フォーラム第52回研究報告会
- Data Source
  KAKENHI-PLANNED-17H06411
[Presentation] Identification of an inhibitor of the yeast fatty acid synthase2019
- Author(s)
  Yoko Yashiroda, Sheena Claire Li, Mami Yoshimura, Hiromi Kimurs, Norio Kudo, Hamid Safizadhe, Scott Simpkins, Justin Nelson, Hiroyuki Hirano, Hiroyuki Osada, Minoru Yoshida, Chad Myers, Charles Boone
- Organizer
  The 1st International Symposium on Chemical Communication (ISCC2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06411
[Presentation] 酵母ケミカルゲノミクス法を用いた化合物の標的同定2019
- Author(s)
  八代田陽子、吉村麻美、野口峻太朗、Sheena Li、木村寛美、河村優美、吉田稔、酒井隆一、Charles Boone
- Organizer
  「化学コミュニケーションのフロンティア」第6回公開シンポジウム
- Data Source
  KAKENHI-PLANNED-17H06411
[Presentation] Target identification using an integrated chemical genomic approach2019
- Author(s)
  Sheena Li, Mami Yoshimura, Hamid Safizadhe, Scott Simpkins, Justin Nelson, Yuichi Shichino, Yoko Yashiroda, Shintaro Iwasaki, Hiroyuki Hirano, Hiroyuki Osada, Minoru Yoshida, Chad Myers, Charles Boone
- Organizer
  The 1st International Symposium on Chemical Communication (ISCC2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06411
[Presentation] An Integrated Chemical Genomic Approach for Target Identification2019
- Author(s)
  Yoko Yashiroda, Sheena Li, Urvi Bhojoo, Mami Yoshimura, Hiromi Kimura, Yumi Kawamura, Hamid Safizadeh, Scott Simpkins, Justin Nelson, Hiroyuki Hirano, Hiroyuki Osada, Minoru Yoshida, Chad Myers, Charles Boone
- Organizer
  「化学コミュニケーションのフロンティア」第5回公開シンポジウム
- Data Source
  KAKENHI-PLANNED-17H06411
[Presentation] Mapping Chemical-Genetic Interactions to Link Bioactive Compounds to Cellular Targets2018
- Author(s)
  Charles Boone
- Organizer
  新学術領域研究「化学コミュニケーションのフロンティア」第２回公開シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-15H04483
[Presentation] Mapping Chemical-Genetic Interactions to Link Bioactive Compounds to Cellular Targets2018
- Author(s)
  Charles Boone
- Organizer
  新学術領域研究「化学コミュニケーションのフロンティア」第２回公開シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-17H06411
[Presentation] Target integration using an integrated chemcial genetic approach2018
- Author(s)
  Li Sheena, Boone Charles
- Organizer
  新学術領域研究（研究領域提案型）「化学コミュニケーションのフロンティア」第3回公開シンポジウム
- Data Source
  KAKENHI-PLANNED-17H06411
[Presentation] Mapping Genetic Networks on a Global Scale2017
- Author(s)
  Charles Boone
- Organizer
  From Genetic Networks to a Cellular Wiring Diagram
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06411
[Presentation] A global genetic interaction network maps a wiring diagram of cellular function2017
- Author(s)
  Charles Boone
- Organizer
  Opportunities and Challenges of Exploiting Synthetic Lethality in Cancer
- Place of Presentation
  米国　サンディエゴ
- Year and Date
  2017-01-04
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04483
[Presentation] Mapping Genetic Networks on a Global Scale2017
- Author(s)
  Charles Boone
- Organizer
  From Genetic Networks to a Cellular Wiring Diagram
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04483
[Presentation] Target Identification Using an Integrated Chemical Genetic Approach2017
- Author(s)
  Sheena Li, Charles Boone
- Organizer
  the CIFAR meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06411
[Presentation] Target Identification Using an Integrated Chemical Genetic Approach2017
- Author(s)
  Sheena Li, Charles Boone
- Organizer
  CIFAR meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04483
[Presentation] A global genetic interaction network maps a wiring diagram of cellular function2017
- Author(s)
  Charles Boone
- Organizer
  9th HiHA International Workshop; Toward a comprehensive understanding of a global genetic network within a cell
- Place of Presentation
  広島大学（広島県東広島市）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04483
[Presentation] Global Analysis of Genetic Interaction Networks in Yeast2016
- Author(s)
  Charles Boone
- Organizer
  Human and Mammalian Genetics and Genomics: The 57th McKusick Short Course
- Place of Presentation
  米国　バーハーバー
- Year and Date
  2016-07-17
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04483
[Presentation] Exploring Functional Genetic Suppression Interactions on a Global Scale2016
- Author(s)
  Charles Boone
- Organizer
  CIFAR meeting
- Place of Presentation
  カナダ　トロント
- Year and Date
  2016-04-15
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04483
[Presentation] 化学遺伝学と形態学のプロファイリング解析による細胞壁合成経路を標的にする抗真菌剤の探索2015
- Author(s)
  久保佳蓮,岡田啓希,Abraham Abrera,Sheena Li,Jeff Piotrowski,Chad Myers,八代田陽子,Charlie Boone, 吉田稔,長田裕之,斎藤臣雄,大矢禎一
- Organizer
  第67回日本細胞生物学会大会
- Place of Presentation
  タワーホール船堀（東京都江戸川区）
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-15H04483
[Presentation] Functional annotation of biological processes targeted by chemical libraries2015
- Author(s)
  Sheena Li, Charlie Boone
- Organizer
  27° International conference on yeast genetics and molecular biology
- Place of Presentation
  Levico Terme, Italy
- Year and Date
  2015-09-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04483

1. 八代田陽子 (60360658)

# of Collaborated Projects: 2 results

# of Collaborated Products: 26 results
2. Kakeya Hideaki (00270596)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 大矢禎一 (20183767)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 松永茂樹 (60183951)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 西尾和人 (10208134)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 入江一浩 (00168535)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 村田道雄 (40183652)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 上田実 (60265931)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 上杉志成 (10402926)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 菊地和也 (70292951)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 榊原康文 (10287427)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 長田裕之 (80160836)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 河岸洋和 (70183283)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Pham LienThiKim (50865300)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
15. 山中大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 野田陽一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 吉田稔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Boone Charles ＢＯＯＮＥ ＣＨＡＲＬＥＳ

Research Projects

Research Products

Co-Researchers

A fission yeast chemical-genomics platform for systematic functional annotation of novel bioactive compoundsPrincipal Investigator

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Target identification with systematic CRISPR-based chemical-genetic profiling in human HAP1 cellsPrincipal Investigator

Principal Investigator

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A chemical genomics approach for understanding chemical communicationPrincipal Investigator

Principal Investigator

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Frontiers in Chemical Communications

Principal Investigator

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Review Section

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Linking novel bioactive compounds to their targets and pathways using chemical genomics and morphological profilingPrincipal Investigator

Principal Investigator

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Research Institution

[Journal Article] The proteomic landscape of genome-wide genetic perturbations.2023

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[Journal Article] Overexpression profiling reveals cellular requirements in the context of genetic backgrounds and environments2023

Author(s)

Journal Title

DOI

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[Journal Article] Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity2023

Author(s)

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[Journal Article] N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity.2023

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[Journal Article] BIONIC: Biological Network Integration Using Convolutions2022

Author(s)

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[Journal Article] Jerveratrum-Type Steroidal Alkaloids Inhibit β-1,6-Glucan Biosynthesis in Fungal Cell Walls2022

Author(s)

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[Journal Article] High-throughput platform for yeast morphological profiling predicts the targets of bioactive compounds2022

Author(s)

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[Journal Article] Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets2021

Author(s)

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[Journal Article] Clionamines stimulate autophagy, inhibit Mycobacterium tuberculosis survival in macrophages, and target Pik12021

Author(s)

Journal Title

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Data Source

[Journal Article] Genome-wide Screening of Genes Associated with Momilactone B Sensitivity in the Fission Yeast2021

Boone Charles ＢＯＯＮＥＣＨＡＲＬＥＳ