Watanabe Seiji 渡邊征爾

… Alternative Names

WATANABE Seiji 渡邊征爾

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Researcher Number	70633577
Other IDs
Affiliation (Current)	2025: 名古屋大学, 環境医学研究所, 講師
Affiliation (based on the past Project Information) *help	2023: 名古屋大学, 環境医学研究所, 講師 2014 – 2022: 名古屋大学, 環境医学研究所, 助教 2013: 名古屋大学, 環境医学研究所, 研究員
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Nerve anatomy/Neuropathology / Pathological medical chemistry Except Principal Investigator Medium-sized Section 52:General internal medicine and related fields / Biological Sciences / Bioorganic chemistry
Keywords	Principal Investigator 筋萎縮性側索硬化症 / TDP-43 / σ1受容体 / SOD1 / 小胞体・ミトコンドリア膜間領域 / タンパク質凝集 / アグリソーム / 前頭側頭葉変性症 / FUS / ミトコンドリア・小胞体膜間領域 / TBK1 / TANK結合キナーゼ1 … More Except Principal Investigator … More 神経変性疾患 / 構造生物学 / 筋萎縮性側索硬化症 / 細胞外環境 / 脊髄 / 脊髄環境 / 環境 / グリア / 分子酸化 / プロオキシダント性 / 抗酸化 / protein stability / G6PDH / superoxide dismutase / hydroxyl radical / copper-induced oxidation / prooxidant / antioxidant / 蛋白質変性 / スーパーオキシドディスムターゼ 1 / ヒドロキシルラジカル / 銅イオン還元能 / プロオキシダント能 / 抗酸化能 Less

TDP-43単量体の細胞質における凝集機序の解明Principal Investigator
- Principal Investigator
  
  渡邊征爾
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Nagoya University
タンパク質の構造生物学に基づいた筋萎縮性側索硬化症の分子病態解明と治療法開発
- Principal Investigator
  
  山中宏二
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Nagoya University
Disruption of the mitochondria-associated membranes as a general pathomechanism in amyotrophic lateral sclerosisPrincipal Investigator
- Principal Investigator
  
  Watanabe Seiji
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Nagoya University
Investigation on antioxidants with low pro-oxidant activity to stabilize proteins responsible for neurodegenerative disease.
- Principal Investigator
  
  KUROKAWA Yoichi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Fukui Prefectural University
Disruption of mitochondria-associated membrane in neurodegenerative diseasePrincipal Investigator
- Principal Investigator
  
  Watanabe Seiji
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nagoya University
Spinal cord environment: elucidating the mechanism of neurodegeneration through glia-neuron interaction
- Principal Investigator
  
  Yamanaka Koji
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
  The Institute of Physical and Chemical Research

All 2024 2023 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Genetic background variation impacts microglial heterogeneity and disease progression in amyotrophic lateral sclerosis model mice.2024
- Author(s)
  Komine O., Ohnuma S., Hinohara K., Hara Y., Shimada M., Akashi T., Watanabe S., Sobue A., Kawade N., Ogi T., Yamanaka K..
- Journal Title
  
  iScience
  
  Volume: 27 Issue: 2 Pages: 108872-108872
- DOI
  10.1016/j.isci.2024.108872
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K13902, KAKENHI-PROJECT-23K14687, KAKENHI-PROJECT-23K06826, KAKENHI-PROJECT-20K16488, KAKENHI-PROJECT-21K20569, KAKENHI-PROJECT-22H00467, KAKENHI-PROJECT-23H00516
[Journal Article] Dimethyl fumarate improves cognitive impairment and neuroinflammation in mice with Alzheimer’s disease2024
- Author(s)
  Wang Ting、Sobue Akira、Watanabe Seiji、Komine Okiru、Saido Takaomi C.、Saito Takashi、Yamanaka Koji
- Journal Title
  
  Journal of Neuroinflammation
  
  Volume: 21 Issue: 1 Pages: 55-55
- DOI
  10.1186/s12974-024-03046-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14687, KAKENHI-PROJECT-23K06826, KAKENHI-PROJECT-20K16488, KAKENHI-PROJECT-23K26790
[Journal Article] Sigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis2023
- Author(s)
  Watanabe Seiji、Horiuchi Mai、Murata Yuri、Komine Okiru、Kawade Noe、Sobue Akira、Yamanaka Koji
- Journal Title
  
  Neurobiology of Disease
  
  Volume: 179 Pages: 106031-106031
- DOI
  10.1016/j.nbd.2023.106031
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16488, KAKENHI-PROJECT-21K20569, KAKENHI-PROJECT-19KK0214, KAKENHI-PROJECT-18H02740, KAKENHI-PROJECT-23K06826, KAKENHI-PROJECT-22H00467
[Journal Article] Intrinsic structural vulnerability in the hydrophobic core induces species-specific aggregation of canine SOD1 with degenerative myelopathy-linked E40K mutation2023
- Author(s)
  Hashimoto Kei、Watanabe Seiji、Akutsu Masato、Muraki Norifumi、Kamishina Hiroaki、Furukawa Yoshiaki、Yamanaka Koji
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 299 Issue: 6 Pages: 104798-104798
- DOI
  10.1016/j.jbc.2023.104798
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0214, KAKENHI-PROJECT-23K05670, KAKENHI-PROJECT-23K06826, KAKENHI-PROJECT-22KJ1574, KAKENHI-PLANNED-19H05765, KAKENHI-PROJECT-23K24031, KAKENHI-PROJECT-22H00467
[Journal Article] Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis2023
- Author(s)
  Oiwa Kotaro、Watanabe Seiji、Onodera Kazunari、Iguchi Yohei、Kinoshita Yukako、Komine Okiru、Sobue Akira、Okada Yohei、Katsuno Masahisa、Yamanaka Koji
- Journal Title
  
  Science Advances
  
  Volume: 9 Issue: 31
- DOI
  10.1126/sciadv.adf6895
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15739, KAKENHI-PROJECT-23K14687, KAKENHI-PROJECT-19KK0214, KAKENHI-PROJECT-21K07471, KAKENHI-PROJECT-23K06826, KAKENHI-PROJECT-23K06955, KAKENHI-PROJECT-23K06975, KAKENHI-PROJECT-18K07539, KAKENHI-PROJECT-19K07969, KAKENHI-PROJECT-22K19506, KAKENHI-PROJECT-20K16488, KAKENHI-PROJECT-22H00467, KAKENHI-PROJECT-23K24249
[Journal Article] Mitochondria-associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS2023
- Author(s)
  Watanabe Seiji、Murata Yuri、Oka Yasuyoshi、Oiwa Kotaro、Horiuchi Mai、Iguchi Yohei、Komine Okiru、Sobue Akira、Katsuno Masahisa、Ogi Tomoo、Yamanaka Koji
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 120 Issue: 47
- DOI
  10.1073/pnas.2315347120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14687, KAKENHI-PROJECT-19KK0214, KAKENHI-PROJECT-23K06826, KAKENHI-PROJECT-22K19506, KAKENHI-PROJECT-20K16488, KAKENHI-PROJECT-20H00629, KAKENHI-PROJECT-22H00467
[Journal Article] Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer’s disease2021
- Author(s)
  Sobue Akira、Komine Okiru、Hara Yuichiro、Endo Fumito、Mizoguchi Hiroyuki、Watanabe Seiji、Murayama Shigeo、Saito Takashi、Saido Takaomi C.、Sahara Naruhiko、Higuchi Makoto、Ogi Tomoo、Yamanaka Koji
- Journal Title
  
  Acta Neuropathologica Communications
  
  Volume: 9 Issue: 1 Pages: 111111-111111
- DOI
  10.1186/s40478-020-01099-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06896, KAKENHI-PROJECT-19K21811, KAKENHI-PROJECT-20K16488, KAKENHI-PUBLICLY-19H05017, KAKENHI-PUBLICLY-19H05437, KAKENHI-PROJECT-19H03532, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-17H04986
[Journal Article] Novel reporters of mitochondria‐associated membranes (MAM), MAMtrackers, demonstrate MAM disruption as a common pathological feature in amyotrophic lateral sclerosis2021
- Author(s)
  Sakai Shohei、Watanabe Seiji、Komine Okiru、Sobue Akira、Yamanaka Koji
- Journal Title
  
  The FASEB Journal
  
  Volume: 35 Issue: 7
- DOI
  10.1096/fj.202100137r
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04986, KAKENHI-PROJECT-20K16488, KAKENHI-PROJECT-19KK0214, KAKENHI-ORGANIZER-17H06413
[Journal Article] Aggresome formation and liquid?liquid phase separation independently induce cytoplasmic aggregation of TAR DNA-binding protein 432020
- Author(s)
  Watanabe Seiji、Inami Hidekazu、Oiwa Kotaro、Murata Yuri、Sakai Shohei、Komine Okiru、Sobue Akira、Iguchi Yohei、Katsuno Masahisa、Yamanaka Koji
- Journal Title
  
  Cell Death & Disease
  
  Volume: 11 Issue: 10 Pages: 909-909
- DOI
  10.1038/s41419-020-03116-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16488, KAKENHI-PROJECT-19KK0214, KAKENHI-PROJECT-20H03589, KAKENHI-PROJECT-18H02740, KAKENHI-PROJECT-17H04986
[Journal Article] Novel Selenium-based compounds with therapeutic potential for SOD1-linked amyotrophic lateral sclerosis2020
- Author(s)
  Amporndanai Kangsa、Rogers Michael、Watanabe Seiji、Yamanaka Koji、O'Neill Paul M.、Hasnain S. Samar
- Journal Title
  
  EBioMedicine
  
  Volume: 59 Pages: 102980-102980
- DOI
  10.1016/j.ebiom.2020.102980
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0214, KAKENHI-PROJECT-18H02740, KAKENHI-PROJECT-17H04986
[Journal Article] ALS-linked TDP-43M337V knock-in mice exhibit splicing deregulation without neurodegeneration2020
- Author(s)
  Watanabe Seiji、Oiwa Kotaro、Murata Yuri、Komine Okiru、Sobue Akira、Endo Fumito、Takahashi Eiki、Yamanaka Koji
- Journal Title
  
  Molecular Brain
  
  Volume: 13 Issue: 1 Pages: 8-8
- DOI
  10.1186/s13041-020-0550-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0214, KAKENHI-PUBLICLY-18H04860, KAKENHI-PROJECT-18H02740, KAKENHI-PROJECT-17H04986, KAKENHI-PROJECT-19K21221
[Journal Article] Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1?Akt signaling pathway2019
- Author(s)
  Nishino Kohei、Watanabe Seiji、Shijie Jin、Murata Yuri、Oiwa Kotaro、Komine Okiru、Endo Fumito、Tsuiji Hitomi、Abe Manabu、Sakimura Kenji、Mishra Amit、Yamanaka Koji
- Journal Title
  
  Acta Neuropathologica Communications
  
  Volume: 7 Issue: 1 Pages: 118-118
- DOI
  10.1186/s40478-019-0776-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01972, KAKENHI-PUBLICLY-18H04860, KAKENHI-PROJECT-18H02540, KAKENHI-PROJECT-18H02740, KAKENHI-PROJECT-17H04986
[Journal Article] Intracerebroventricular administration of Cystatin C ameliorates disease in SOD1-linked amyotrophic lateral sclerosis mice2018
- Author(s)
  Watanabe Seiji、Komine Okiru、Endo Fumito、Wakasugi Keisuke、Yamanaka Koji
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 145 Issue: 1 Pages: 80-89
- DOI
  10.1111/jnc.14285
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K14963, KAKENHI-PROJECT-17H04986, KAKENHI-PROJECT-16K09671, KAKENHI-PROJECT-17K07329
[Journal Article] A copper-deficient form of mutant cu/Zn-superoxide dismutase as an early pathological species in amyotrophic lateral sclerosis2018
- Author(s)
  Tokuda Eiichi、Nomura Takao、Ohara Shinji、Watanabe Seiji、Yamanaka Koji、Morisaki Yuta、Misawa Hidemi、Furukawa Yoshiaki
- Journal Title
  
  Biochimica et Biophysica Acta - Molecular Basis of Disease
  
  Volume: 印刷中 Issue: 6 Pages: 2119-2130
- DOI
  10.1016/j.bbadis.2018.03.015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05705, KAKENHI-PROJECT-16H04768, KAKENHI-PROJECT-16K16634, KAKENHI-PROJECT-18K05329, KAKENHI-PUBLICLY-18H04860, KAKENHI-PROJECT-17H04986, KAKENHI-PROJECT-17K15077
[Journal Article] Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes2018
- Author(s)
  Komine Okiru、Yamashita Hirofumi、Fujimori-Tonou Noriko、Koike Masato、Jin Shijie、Moriwaki Yasuhiro、Endo Fumito、Watanabe Seiji、Uematsu Satoshi、Akira Shizuo、Uchiyama Yasuo、Takahashi Ryosuke、Misawa Hidemi、Yamanaka Koji
- Journal Title
  
  Cell Death & Differentiation
  
  Volume: 印刷中 Issue: 12 Pages: 2130-2146
- DOI
  10.1038/s41418-018-0098-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-26293208, KAKENHI-PUBLICLY-16H01336, KAKENHI-PUBLICLY-17H05698, KAKENHI-PROJECT-17H04257, KAKENHI-PROJECT-18H02571, KAKENHI-PROJECT-18H02740, KAKENHI-PROJECT-17H04986, KAKENHI-PROJECT-17K19543, KAKENHI-PROJECT-17K14963
[Journal Article] Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis2017
- Author(s)
  Eiichi Tokuda, Itsuki Anzai, Takao Nomura, Keisuke Toichi, Masahiko Watanabe, Shinji Ohara, Seiji Watanabe, Koji Yamanaka, Yuta Morisaki, Hidemi Misawa, and Yoshiaki Furukawa
- Journal Title
  
  Molecular Neurodegeneration
  
  Volume: 12 Issue: 1 Pages: 2-2
- DOI
  10.1186/s13024-016-0145-9
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01566, KAKENHI-PROJECT-16H04768, KAKENHI-PROJECT-26293208, KAKENHI-PROJECT-15K14480, KAKENHI-PROJECT-25860252
[Journal Article] TDP-43 accelerates age-dependent degeneration of interneurons2017
- Author(s)
  Tsuiji Hitomi、Inoue Ikuyo、Takeuchi Mari、Furuya Asako、Yamakage Yuko、Watanabe Seiji、Koike Masato、Hattori Mitsuharu、Yamanaka Koji
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 14972-14972
- DOI
  10.1038/s41598-017-14966-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08280, KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-26293208, KAKENHI-PROJECT-17H04986, KAKENHI-PROJECT-16H06280
[Journal Article] Chimeric ZHHH neuroglobin acts as a cell membrane-penetrating inducer of neurite outgrowth2017
- Author(s)
  Takahashi Nozomu、Onozuka Wataru、Watanabe Seiji、Wakasugi Keisuke
- Journal Title
  
  FEBS Open Bio
  
  Volume: 7 Issue: 9 Pages: 1338-1349
- DOI
  10.1002/2211-5463.12271
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07329, KAKENHI-PROJECT-17H04986
[Journal Article] Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons.2016
- Author(s)
  Lasiene J, Komine O, Fujimori-Tonou N, Powers B, Endo F, Watanabe S, Shijie J, Ravits J, Horner P, Misawa H, Yamanaka K
- Journal Title
  
  Acta Neuropathologica Communications
  
  Volume: 4 Issue: 1 Pages: 15-15
- DOI
  10.1186/s40478-016-0286-7
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860252, KAKENHI-PROJECT-26830046, KAKENHI-PLANNED-23111006, KAKENHI-PROJECT-25293020, KAKENHI-PROJECT-26293208
[Journal Article] Mitochondria-associated membrane collapse is a common pathomechanism in SIGMAR1- and SOD1-linked ALS.2016
- Author(s)
  Watanabe S, Ilieva H, Tamada H, Nomura H, Komine O, Endo F, Jin S, Mancias P, Kiyama H, *Yamanaka K.
- Journal Title
  
  EMBO Molecular Medicine
  
  Volume: 8 Issue: 12 Pages: 1421-1437
- DOI
  10.15252/emmm.201606403
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01336, KAKENHI-PROJECT-16H05117, KAKENHI-PROJECT-26293208, KAKENHI-PROJECT-15K19321, KAKENHI-PROJECT-25860252, KAKENHI-PROJECT-26830046, KAKENHI-PROJECT-16K09671
[Journal Article] Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells.2015
- Author(s)
  Endo F, Komine O, Fujimori-Tonou N, Katsuno M, Jin S, Watanabe S, Sobue G, Dezawa M, Wyss-Coray T, Yamanaka K
- Journal Title
  
  Cell Reports
  
  Volume: 11 Issue: 4 Pages: 592-604
- DOI
  10.1016/j.celrep.2015.03.053
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860252, KAKENHI-PROJECT-26830046, KAKENHI-ORGANIZER-23111001, KAKENHI-PROJECT-26670439, KAKENHI-PROJECT-26293206, KAKENHI-PROJECT-26293208, KAKENHI-PLANNED-26117002, KAKENHI-ORGANIZER-26117001
[Journal Article] Mahogunin ring finger 1 confers cytoprotection against mutant SOD1 aggresomes and is defective in an ALS mouse model.2015
- Author(s)
  Chhangani D, Endo F, Amanullah A, Upadhyay A, Watanabe S, Mishra R, Yamanaka K, Mishra A
- Journal Title
  
  Neurobiology of Disease
  
  Volume: 86 Pages: 16-16
- DOI
  10.1016/j.nbd.2015.11.017
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860252, KAKENHI-PLANNED-23111006, KAKENHI-PROJECT-26293208
[Journal Article] Cystatin C protects neuronal cells against mutant copper-zinc superoxide dismutase-mediated toxicity.2014
- Author(s)
  WATANABE Seiji, HAYAKAWA Tomoyo, Wakasugi Keisuke, YAMANAKA Koji
- Journal Title
  
  Cell Death & Disease
  
  Volume: 5 Issue: 10 Pages: e1497-e1497
- DOI
  10.1038/cddis.2014.459
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23111006, KAKENHI-PROJECT-25860252, KAKENHI-PROJECT-26293208, KAKENHI-PROJECT-26440047
[Journal Article] SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system.2014
- Author(s)
  Watanabe S, Ageta-Ishihara N, Nagatsu S, Takao K, Komine O, Endo F, Miyakawa T, Misawa H, Takahashi R, Kinoshita M, Yamanaka K.
- Journal Title
  
  Mol Brain
  
  Volume: 7 Issue: 1 Pages: 62-62
- DOI
  10.1186/s13041-014-0062-1
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-221S0003, KAKENHI-PLANNED-23111006, KAKENHI-PUBLICLY-25116514, KAKENHI-PUBLICLY-25116526, KAKENHI-PROJECT-25293020, KAKENHI-PROJECT-25350989, KAKENHI-PROJECT-25860252, KAKENHI-PUBLICLY-26115529, KAKENHI-PROJECT-26293208, KAKENHI-PROJECT-26440095, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-25242078
[Journal Article] Intranuclear aggregation of mutant FUS/TLS as a molecular pathomechanism of amyotrophic lateral sclerosis2014
- Author(s)
  Nomura, T., Watanabe, S., Kaneko, K., Yamanaka, K., Nukina, N. & Furukawa, Y.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 289 Issue: 2 Pages: 1192-1202
- DOI
  10.1074/jbc.m113.516492
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22110004, KAKENHI-PLANNED-23111006, KAKENHI-PUBLICLY-24111542, KAKENHI-PROJECT-24657093, KAKENHI-PROJECT-24659436, KAKENHI-PROJECT-25291028
[Journal Article] Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life.2014
- Author(s)
  AUSTIN James J., WRIGHT Gareth S., WATANABE Seiji, GROSSMANN Gunter, ANTONYUK Svetlana V., YAMANAKA Koji, HASNAIN S. Samar
- Journal Title
  
  Proceedings of the National Academy of Sciences of U.S.A.
  
  Volume: 111 Issue: 11 Pages: 4309-4314
- DOI
  10.1073/pnas.1317317111
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23111006, KAKENHI-PROJECT-25860252
[Journal Article] Intracellular seeded aggregation of mutant Cu,Zn-superoxide dismutase associated with amyotrophic lateral sclerosis2013
- Author(s)
  Furukawa, Y., Kaneko, K., Watanabe, S., Yamanaka, K. & Nukina, N.
- Journal Title
  
  FEBS Lett.
  
  Volume: 587 Issue: 16 Pages: 2500-2505
- DOI
  10.1016/j.febslet.2013.06.046
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22110004, KAKENHI-PLANNED-23111006, KAKENHI-PUBLICLY-24111542, KAKENHI-PROJECT-24657093, KAKENHI-PROJECT-24659436, KAKENHI-PROJECT-25291028
[Journal Article] Crucial roles of glu60 in human neuroglobin as a Guanine nucleotide dissociation inhibitor and neuroprotective agent.2013
- Author(s)
  Takahashi N, Watanabe S, Wakasugi K
- Journal Title
  
  PLOS ONE
  
  Volume: 8 Issue: 12 Pages: e83698-e83698
- DOI
  10.1371/journal.pone.0083698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860252
[Journal Article] Accelerated disease onset with stabilized familial amyotrophic lateral sclerosis (ALS)-linked mutant TDP-43 proteins.2013
- Author(s)
  Shoji Watanabe et al.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 288 Issue: 5 Pages: 3641-3654
- DOI
  10.1074/jbc.m112.433615
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23111006
[Presentation] ALS病態に関連した単量体TDP-43の細胞質における凝集メカニズムの解明2023
- Author(s)
  柳澤紗良、渡邊征爾、大岩康太郎、山中宏二
- Organizer
  第46回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-23K06826
[Presentation] マウスにおけるオリゴデンドロサイト特異的な変異型TDP-43過剰発現は運動機能障害を惹起する.2023
- Author(s)
  堀内麻衣、渡邊征爾、山中宏二
- Organizer
  第64回日本神経病理学会総会学術研究会第66回日本神経化学会大会合同大会
- Data Source
  KAKENHI-PROJECT-23K06826
[Presentation] A novel reporter, TDP-DiLuc, detects TDP-43 monomerization　preceding TDP-43 pathology2023
- Author(s)
  大岩康太郎, 渡邊征爾, 小野寺一成, 井口洋平, 岡田洋平, 勝野雅央, 山中宏二
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-23K06826
[Presentation] TBK1は単量体化によって誘導されるリン酸化TDP-43の蓄積を抑制する2023
- Author(s)
  酒井昭平、渡邊征爾、大岩康太郎、山中宏二
- Organizer
  第46回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-23K06826
[Presentation] フマル酸ジメチルはアルツハイマー病モデルマウスの認知機能障害および神経炎症を改善する2023
- Author(s)
  Wang Ting、祖父江顕、小峯起、渡邊征爾、齋藤貴志、西道隆臣、山中宏二
- Organizer
  第46回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-23K06826
[Presentation] TBK1は単量体化によって誘導されるリン酸化TDP-43のクリアランスに重要である2023
- Author(s)
  酒井昭平、渡邊征爾、大岩康太郎、山中宏二
- Organizer
  第64回日本神経病理学会総会学術研究会第66回日本神経化学会大会合同大会
- Data Source
  KAKENHI-PROJECT-23K06826
[Presentation] Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis2023
- Author(s)
  Oiwa K, Watanabe S, Onodera K, Iguchi Y, Kinoshita Y, Komine O, Sobue A, Okada Y, Katsuno M, Yamanaka K
- Organizer
  Japan-UK Neuroscience symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06826
[Presentation] タンパク質ストレス応答における小胞体・ミトコンドリア接触部の新たな役割2023
- Author(s)
  渡邊征爾、山中宏二
- Organizer
  第64回日本神経病理学会総会学術研究会第66回日本神経化学会大会合同大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K06826
[Presentation] 筋萎縮性側索硬化症においてσ1受容体はATAD3Aの単量体状態を維持することによってミトコンドリアの断片化を抑制する2023
- Author(s)
  渡邊征爾、堀内麻衣、山中宏二
- Organizer
  第46回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-23K06826
[Presentation] オリゴデンドロサイト特異的なALS関連変異型TDP-43の過剰発現はマウスの運動機能障害を惹起する2023
- Author(s)
  堀内麻衣、渡邊征爾、山中宏二
- Organizer
  第46回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-23K06826
[Presentation] Oligodendrocyte-specific overexpression of mutant TDP-43 induces motor dysfunction in mice.2023
- Author(s)
  Horiuchi M, Watanabe S, Komine O, Yamanaka K.
- Organizer
  THE 50th NAITO CONFERENCE Glia World
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06826
[Presentation] Sigma 1 receptor, an ALS16-causative gene product, prevents mitochondrial fragmentation via ATAD3A in ALS2023
- Author(s)
  Watanabe S, Horiuchi M, Yamanaka K
- Organizer
  34th International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06826
[Presentation] Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in ALS.2021
- Author(s)
  大岩康太郎、渡邊征爾、井口洋平、勝野雅央、山中宏二
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17H04986
[Presentation] スプライソソームの形成異常がTDP-43の単量体化に関与する2021
- Author(s)
  渡邊征爾、木下裕香子、大岩康太郎、山中宏二
- Organizer
  第44回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17H04986
[Presentation] 小胞体・ミトコンドリア接触領域（MAM）の新規レポーターは、MAMの破綻がALSにおける共通の病態的特徴であることを示す2021
- Author(s)
  酒井昭平、渡邊征爾、山中宏二.
- Organizer
  第44回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17H04986
[Presentation] Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in ALS.2021
- Author(s)
  大岩康太郎、渡邊征爾、井口洋平、勝野雅央、山中宏二.
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19KK0214
[Presentation] アグリソーム形成と液-液相分離は独立してTDP-43擬集体の形成を引き起こす2021
- Author(s)
  渡邊征爾、稲見英和、大岩康太郎、酒井昭平、山中宏二
- Organizer
  第62回日本神経学会学術大会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17H04986
[Presentation] Knocking-in the ALS-linked TDP-43M337V mutation in mice induces splicing deregulation without neurodegeneration2021
- Author(s)
  Watanabe S, Oiwa K, Komine O, Sobue A, Yamanaka K
- Organizer
  PACTALS 2021 NAGOYA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04986
[Presentation] ミトコンドリア・小胞体接触領域においてσ1受容体はATAD3Aの異常な多量体化を抑制する.2021
- Author(s)
  渡邊征爾、山中宏二
- Organizer
  第94回日本生化学大会
- Data Source
  KAKENHI-PROJECT-17H04986
[Presentation] Oligodendrocyte-specific overexpression of TDP-43 induces motor dysfunction in mice2021
- Author(s)
  Horiuchi M, Watanabe S, Yamanaka K
- Organizer
  PACTALS 2021 NAGOYA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04986
[Presentation] Novel reporters of mitochondria-associated membrane (MAM) demonstrate MAM disruption as a common pathological feature in inherited ALS.2021
- Author(s)
  Sakai S, Watanabe S, Yamanaka K
- Organizer
  PACTALS 2021 NAGOYA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04986
[Presentation] E40K変異イヌSOD1タンパク質の種特異的凝集に重要なアミノ酸残基の同定.2021
- Author(s)
  橋本　慶、渡邊征爾、小峯起、祖父江顕、神志那弘明、山中宏二.
- Organizer
  第94回日本生化学大会
- Data Source
  KAKENHI-PROJECT-19KK0214
[Presentation] Identification of a key amino acid residue involved in the species-specific aggregation of canine SOD1 with E40K mutation2021
- Author(s)
  Hashimoto K, Watanabe S, Yamanaka K
- Organizer
  PACTALS 2021 NAGOYA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04986
[Presentation] マウスにおけるオリゴデンドロサイト特異的TDP-43過剰発現は運動機能障害を惹起する2021
- Author(s)
  堀内麻衣、渡邊征爾、山中宏二
- Organizer
  第44回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17H04986
[Presentation] E40K変異による種特異的イヌSOD1タンパク凝集メカニズムの解析2021
- Author(s)
  橋本慶、渡邊征爾、小峯起、祖父江顕、神志那弘明、山中宏二.
- Organizer
  第164回日本獣医学会学術集会生理学・生化学分科会
- Data Source
  KAKENHI-PROJECT-17H04986
[Presentation] E40K変異イヌSOD1タンパク質の種特異的凝集に重要なアミノ酸残基の同定2021
- Author(s)
  橋本慶、渡邊征爾、小峯起、祖父江顕、神志那弘明、山中宏二.
- Organizer
  第94回日本生化学大会
- Data Source
  KAKENHI-PROJECT-17H04986
[Presentation] ALS関連変異TDP-43(M337V)ノックインマウスは運動神経変性を伴わないスプライシング異常を生じる2020
- Author(s)
  渡邊征爾、大岩康太郎、小峯起、祖父江顕、山中宏二
- Organizer
  第43回　日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17H04986
[Presentation] Multimerization of TDP-43 plays a key role in determination of its subcellular localization.2020
- Author(s)
  大岩康太郎、渡邊征爾、祖父江　顕、小峯　起、勝野雅央、山中宏二.
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19KK0214
[Presentation] Multimerization of TDP-43 plays a key role in determination of its subcellular localization.2020
- Author(s)
  大岩康太郎、渡邊征爾、祖父江顕、小峯起、勝野雅央、山中宏二
- Organizer
  第61回　日本神経学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04986
[Presentation] Disruption of mitochondria-associated membranes in amyotrophic lateral sclerosis.2019
- Author(s)
  Watanabe S
- Organizer
  Japan-UK Neuroscience Symposium 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04986
[Presentation] 家族性ALS/FTLD原因遺伝子によって引き起こされるTDP-43の凝集は2つの異なる経路によって生じる2019
- Author(s)
  渡邊征爾、大岩康太郎、山中宏二
- Organizer
  第42回日本神経科学大会第62回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-17H04986
[Presentation] TDP-43 mutant lacking its C-terminal domain induces age-dependent motor dysfunction in mice.2019
- Author(s)
  Watanabe S, Nishino K, Murata Y, Oiwa K, Yamanaka K.
- Organizer
  30th International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0214
[Presentation] TDP-43の多量体化が、その細胞内局在の決定に重要である2019
- Author(s)
  大岩康太郎、渡邊征爾、祖父江　顕、小峯起、勝野雅央、山中宏二
- Organizer
  第42回日本神経科学大会第62回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-17H04986
[Presentation] TDP-43 mutant lacking its C-terminal domain induces age-dependent motor dysfunction in mice2019
- Author(s)
  Watanabe S, Nishino K, Murata Y, Oiwa K, Yamanaka K
- Organizer
  30th International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04986
[Presentation] TDP-43C末端ドメイン欠損変異体はNotch1-Akt1シグナル経路を介して加齢依存的な運動障害を引き起こす.2018
- Author(s)
  渡邊征爾、西野晃平、松岡由理、金　世杰、小峯　起、遠藤史人、築地仁美、﨑村健司、山中宏二
- Organizer
  第41回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17H04986
[Presentation] Intracerebroventricular administration of cystatin C extended the survival time of SOD1G93A mouse model.2018
- Author(s)
  Watanabe S, Komine O, Endo F, Wakasugi K, Yamanaka K
- Organizer
  the29th International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04986
[Presentation] Screening of familial ALS/FTLD causative genes identifies mechanism of TDP43 aggregation in cultured neuronal cells.2018
- Author(s)
  Inami H, Watanabe S, Yamanaka K.
- Organizer
  第40回日本生物学的精神医学会第61回日本神経化学会大会合同年会
- Data Source
  KAKENHI-PROJECT-17H04986
[Presentation] Mice deficient of C-terminal domain of TDP-43 develop age-dependent motor dysfunction via Notch1-Akt signaling pathway.2018
- Author(s)
  Watanabe S, Nishino K, Matsuoka Y, Jin S, Komine O, Endo F, Tsuiji H, Sakimura K, Mishra A, Yamanaka K.
- Organizer
  5th RNA Metabolism in Neurological Disease Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04986
[Presentation] ALS共通病態としての小胞体・ミトコンドリア膜間領域（MAM）破綻の検証2018
- Author(s)
  渡邊征爾
- Organizer
  第40回日本生物学的精神医学会第61回日本神経化学会大会合同年会
- Data Source
  KAKENHI-PROJECT-17H04986
[Presentation] Innate immune adaptor TRIF confers neuroprotection in ALS mice by eliminating abnormal astrocytes.2018
- Author(s)
  Komine O, Yamashita H, Fujimori-Tonou N, Koike M, Jin S, Moriwaki Y, Endo F, Watanabe S, Uematsu S, Akira S, Uchiyama Y, Takahashi R, Misawa H, Yamanaka K
- Organizer
  Society for Neuroscience 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04986
[Presentation] ニューログロビンがもつ神経突起伸長能の作用機序の解析2017
- Author(s)
  高橋望，小野塚渉，渡邊征爾，若杉桂輔
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17H04986
[Presentation] Mice Heterozygously lacking C-terminal domain of TDP-43 show age-dependent motor dysfunction.2017
- Author(s)
  Nishino K, Watanabe S, Endo F, Yamanaka K
- Organizer
  第23回世界神経学会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04986
[Presentation] 小胞体・ミトコンドリア膜間領域は、筋萎縮性側索硬化症（ALS）の新規治療標的である2017
- Author(s)
  渡邊征爾，小峯起，遠藤史人，山中宏二
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17H04986
[Presentation] 筋萎縮性側索硬化症におけるシスタチンCの神経保護効果2017
- Author(s)
  渡邊征爾，小峯起，遠藤史人，山中宏二
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17H04986
[Presentation] Neuregulin 1 confers neuroprotection in SOD1-linked ALS mice via restoration of C-boutons of spinal motor neurons.2016
- Author(s)
  Komine O, Lasiene J, Fujimori-Tonou N, Powers B, Endo F, Watanabe S, Jin S, Ravits J, Horner P, Misawa H, Yamanaka K.
- Organizer
  The 27th International Symposium on ALS/MND
- Place of Presentation
  アイルランド, ダブリン
- Year and Date
  2016-12-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860252
[Presentation] Disruption of Mitochondria-associated membrance is a common pathomechanism both in SOD1-and SIGMAR1-linked ALS.2016
- Author(s)
  Watanabe S, Yamanaka K
- Organizer
  The 27th International Symposium on ALS/MND
- Place of Presentation
  アイルランド, ダブリン
- Year and Date
  2016-12-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860252
[Presentation] Disruption of mitochondria associated membrane in amyotrophic lateral sclerosis.2016
- Author(s)
  Watanabe S, Yamanaka K
- Organizer
  第６回生理学研究所・名古屋大学医学系研究科合同シンポジウム
- Place of Presentation
  名古屋大学鶴舞キャンパス
- Year and Date
  2016-09-24
- Data Source
  KAKENHI-PROJECT-25860252
[Presentation] In vivo and in vitro characterization of SOD1 in early stages of ALS as a precursor to insoluble aggregates.2016
- Author(s)
  Tokuda E, Anzai I, Nomura T, Ohara S, Watanabe S, Yamanaka K, Morisaki Y, Misawa H, Furukawa Y.
- Organizer
  The 27th International Symposium on ALS/MND
- Place of Presentation
  アイルランド, ダブリン
- Year and Date
  2016-12-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860252
[Presentation] Astrocyte-derived TGF-β1 accelerates disease progression in ALS mice by regulating the neuroprotective inflammatory response of microglia and T cells.2015
- Author(s)
  山中宏二、遠藤史人、小峯起、金世杰、渡邊征爾
- Organizer
  第58回日本神経化学会大会
- Place of Presentation
  大宮ソニックシティ
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-25860252
[Presentation] アストロサイト由来TGF-β1はALSの疾患進行を規定する.2015
- Author(s)
  遠藤史人、小峯起、金世杰、渡邊征爾、山中宏二
- Organizer
  第27回日本神経免疫学会学術集会
- Place of Presentation
  長良川国際会議場
- Year and Date
  2015-09-15
- Data Source
  KAKENHI-PROJECT-25860252
[Presentation] Sigma 1 receptor deficiency is involved in motor neuronal degeneration through calcium deregulation at mitochondria-associated membrane.2015
- Author(s)
  渡邊征爾、山中宏二
- Organizer
  第58回日本神経化学会大会
- Place of Presentation
  大宮ソニックシティ
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-25860252
[Presentation] The role of innate immune TRIF pathway in amyotrophic lateral sclerosis.2015
- Author(s)
  小峯起、山下博史、藤森典子、森脇康博、遠藤史人、渡邊征爾、金世杰、三澤日出巳、山中宏二
- Organizer
  第5回名古屋大学医学系研究科・生理学研究所合同シンポジウム
- Place of Presentation
  生理学研究所
- Year and Date
  2015-09-19
- Data Source
  KAKENHI-PROJECT-25860252
[Presentation] Mahogunin ring finger 1 confers cytoprotection against mutant SOD1 and is defective in ALS mice. 26th International Symposium on ALS/MLD2015
- Author(s)
  Chhangani D, Endo F, Amanullah A, Watanabe S, Mishra R, Mishra A, Yamanaka K
- Organizer
  26th International Symposium on ALS/MLD
- Place of Presentation
  Orlando, USA
- Year and Date
  2015-12-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860252
[Presentation] Calcium deregulation atmitochondria-associated membrane is important for motor neuronal degeneration in amyotrophic lateral sclerosis.2015
- Author(s)
  Watanabe S, Yamanaka K
- Organizer
  BMB2015(第38回日本分子生物学会年会、第88回日本生化学会大会合同大会)
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25860252
[Presentation] 変異スーパーオキシドジスムターゼ1（SOD1）はSOD1（G93A）マウスにおいてミトコンドリア・小胞体膜間領域に蓄積する2013
- Author(s)
  渡邊征爾, 山中宏二
- Organizer
  Neuro2013（第36回日本神経科学大会・第56回日本神経化学会大会・第23回日本神経回路学会大会合同大会）
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-25860252
[Presentation] Cystatin C protected neuronal cells against mutant copper-zinc superoxide dismutase-mediated toxicity in vitro.2013
- Author(s)
  Seiji Watanabe, Keisuke Wakasugi, Koji Yamanaka
- Organizer
  24th International Symposium on ALS/MND
- Place of Presentation
  Milan, Italy
- Data Source
  KAKENHI-PROJECT-25860252
[Presentation] 変異SOD1由来の毒性に対するシスタチンCの神経細胞保護機構の解明
- Author(s)
  渡邊征爾, 若杉桂輔, 山中宏二
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-25860252
[Presentation] Coordinated activation of autophagy and Cathepsin-mediated proteolysis inhibition is essential for neuroprotection by Cystatin C against mutant SOD1-mediated toxicity.
- Author(s)
  Watanabe S, Wakasugi K, Yamanaka K
- Organizer
  25th International Symposium on ALS/MND
- Place of Presentation
  Brussels, Belgium
- Year and Date
  2014-12-05 – 2014-12-07
- Data Source
  KAKENHI-PROJECT-25860252

1. YAMANAKA Koji (80446533)

# of Collaborated Projects: 4 results

# of Collaborated Products: 27 results
2. KUROKAWA Yoichi (40326088)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. OHIGASHI Hajime (80026583)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. KANO Kenji (10152828)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. IRIE Kazuhiro (00168535)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MISAWA Hidemi (80219617)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YAMASHITA Hirofumi (60402913)

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8. MORIWAKI Yasuhiro (00392150)

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9. KOMINE Okiru (00456211)

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10. ENDO Fumito (10713307)

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11. 祖父江顕 (80823343)

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12. TSUIJI Hitomi

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13. TAKAO Keizo

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14. 山中智行

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15. 貫名信行

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16. 古川良明

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17. 佐原成彦

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18. 阿部学

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19. 宮川剛

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20. 阿部修

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21. 高尾昌樹

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22. 渡辺雅彦

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23. 石原健

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24. 高尾英正

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25. 高橋良輔

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26. 伊佐正

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27. 饗場篤

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28. 高橋淑子

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29. 木下専

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30. 若杉桂輔

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31. 川出野絵

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32. 小池正人

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33. 小野寺一成

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Watanabe Seiji 渡邊 征爾

WATANABE Seiji 渡邊 征爾

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TDP-43単量体の細胞質における凝集機序の解明Principal Investigator

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タンパク質の構造生物学に基づいた筋萎縮性側索硬化症の分子病態解明と治療法開発

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Disruption of the mitochondria-associated membranes as a general pathomechanism in amyotrophic lateral sclerosisPrincipal Investigator

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Investigation on antioxidants with low pro-oxidant activity to stabilize proteins responsible for neurodegenerative disease.

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Disruption of mitochondria-associated membrane in neurodegenerative diseasePrincipal Investigator

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Spinal cord environment: elucidating the mechanism of neurodegeneration through glia-neuron interaction

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[Journal Article] Genetic background variation impacts microglial heterogeneity and disease progression in amyotrophic lateral sclerosis model mice.2024

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[Journal Article] Dimethyl fumarate improves cognitive impairment and neuroinflammation in mice with Alzheimer’s disease2024

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[Journal Article] Sigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis2023

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[Journal Article] Intrinsic structural vulnerability in the hydrophobic core induces species-specific aggregation of canine SOD1 with degenerative myelopathy-linked E40K mutation2023

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[Journal Article] Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis2023

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[Journal Article] Mitochondria-associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS2023

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[Journal Article] Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer’s disease2021

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[Journal Article] Novel reporters of mitochondria‐associated membranes (MAM), MAMtrackers, demonstrate MAM disruption as a common pathological feature in amyotrophic lateral sclerosis2021

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Watanabe Seiji 渡邊征爾

WATANABE Seiji 渡邊征爾