Haeno Hiroshi 波江野洋

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HAENO HIROSHI 波江野洋

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Researcher Number	70706754
Other IDs
Affiliation (Current)	2025: 東京理科大学, 研究推進機構生命医科学研究所, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2025: 東京理科大学, 研究推進機構生命医科学研究所, 准教授 2019 – 2021: 東京大学, 大学院新領域創成科学研究科, 特任准教授 2018: 国立研究開発法人国立がん研究センター, 先端医療開発センター, 特任研究員 2016 – 2017: 九州大学, 理学研究院, 助教 2013 – 2015: 九州大学, 理学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 62010:Life, health and medical informatics-related / Biological Sciences / Biophysics Except Principal Investigator Biological Sciences / Basic Section 50010:Tumor biology-related / Basic Section 54010:Hematology and medical oncology-related / Basic Section 58030:Hygiene and public health-related: excluding laboratory approach / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / Digestive surgery
Keywords	Principal Investigator 数理モデル / 確率過程 / 数理モデル研究 / 発がん過程 / ステムセルエイジング / 幹細胞老化 / がん進化 / シミュレーション解析 / 造血器腫瘍 Except Principal Investigator ゲノム … More / エイジング / 疾患 / 老化 / 幹細胞 / ステムセルエイジング / スーパーコンピュータ / 空間的オミックス解析 / エピゲノム / RNA解析 / ゲノム・メタゲノム / 次世代シーケンサー / バイオインフォマティクス / シングルセル解析 / オミックス解析 / メタゲノム / 転写バリアント / 大腸癌 / 全長転写産物解析 / ロングリードシーケンサー / 腫瘍免疫 / 大腸がん / 抗腫瘍免疫 / 子宮頸部上皮内腫瘍 / 免疫チェックポイント阻害剤 / 抗原提示 / マイクロサテライト不安定性 / 骨髄ニッチ / 骨髄造血 / 造血幹細胞 / 数理モデリング / 血液悪性腫瘍 / 同種造血幹細胞移植 / 分子疫学 / 病理学 / 遺伝学 / 癌 / 発がん / 治療標的 / 遺伝子 / がん / 肝臓外科 / 肝再生モデル / 肝臓再生モデル / 数理モデル / 幹細胞老化と疾患 / 総括班 / 加齢 Less

無病生存期間データと数理モデルを用いた組織特異的発がんプロセスの網羅解析Principal Investigator
- Principal Investigator
  
  波江野洋
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  Tokyo University of Science
Platform for Advanced Genome Science
- Principal Investigator
  
  黒川顕
- Project Period (FY)
  2022 – 2027
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (platforms for Advanced Technologies and Research Resources)
- Research Institution
  National Institute of Genetics
Mechanism underlying initiation of bone marrow hematopoiesis in neonate
- Principal Investigator
  
  Takizawa Hitoshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kumamoto University
Study on the mechanisms of immune evasion in microsatellite instability-high tumors
- Principal Investigator
  
  Kawazu Masahito
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Chiba Cancer Center (Research Institute)
血液疾患コホートを利用した治療標的分子探索および数理モデリングによる病態解析
- Principal Investigator
  
  康秀男
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
- Research Institution
  Osaka City University
Prediction of timing of driver mutation and distant metastasis in lung adenocarcinoma
- Principal Investigator
  
  Kohno Takashi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  National Cancer Center Japan
Prediction of postoperative liver regeneration from clinical information using a data-led mathematical model
- Principal Investigator
  
  Yamamoto Kimiyo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka Medical College
Establishing a new paradigm of pathogenesis of the diseases through the understanding of stem cell aging
- Principal Investigator
  
  Iwama Atsushi
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
  Chiba University
Establishing a new paradigm of pathogenesis of the diseases through the understanding of stem cell aging
- Principal Investigator
  
  Iwama Atsushi
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
  Chiba University
Mathematical analysis of the mechanism of cancer initiation with the aging of stem cellsPrincipal Investigator
- Principal Investigator
  
  HAENO HIROSHI
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Cancer Center Japan
  Kyushu University
造血組織における多様な発がん過程の網羅的シミュレーション解析Principal Investigator
- Principal Investigator
  
  波江野洋
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Biophysics
- Research Institution
  Kyushu University

All 2024 2023 2022 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation Book

[Book] 実験医学増刊2017
- Author(s)
  巌佐庸　波江野洋
- Total Pages
  4
- Publisher
  羊土社
- Data Source
  KAKENHI-PLANNED-26115006
[Journal Article] がんの免疫逃避進化のシミュレーションモデル研究2024
- Author(s)
  Haeno HIroshi、Saeki Koichi
- Volume
  42(1)
- Pages
  24
- DOI
  10.18958/7405-00001-0001114-00
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-22H04925
[Journal Article] Subclonal accumulation of immune escape mechanisms in microsatellite instability-high colorectal cancers2023
- Author(s)
  Kobayashi Y, Niida A, Nagayama S, Saeki K, （中略）, Mizuno S, Kawazu M, Kohsaka S, Ueno T, Mano H, Ishihara S, Uemura M, Mori M, Doki Y, Eguchi H, Oshima M, Suzuki Y, Shibata T, Mimori K.
- Journal Title
  
  Br J Cancer
  
  Volume: 129 Issue: 7 Pages: 1105-1118
- DOI
  10.1038/s41416-023-02395-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07153, KAKENHI-PROJECT-21K12117, KAKENHI-PROJECT-22K08894, KAKENHI-PROJECT-22K09006, KAKENHI-PROJECT-23K06662, KAKENHI-PROJECT-23K08128, KAKENHI-PROJECT-21K07179, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-21H02795, KAKENHI-PROJECT-23K24164
[Journal Article] Computational modeling of locoregional recurrence with spatial structure identifies tissue-specific carcinogenic profiles2023
- Author(s)
  Abubakar Sharafudeen Dahiru、Takaki Mitsuaki、Haeno Hiroshi
- Journal Title
  
  Frontiers in Oncology
  
  Volume: 13 Pages: 0-0
- DOI
  10.3389/fonc.2023.1116210
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20J22335, KAKENHI-PROJECT-22H04925
[Journal Article] Mathematical analysis identifies the optimal treatment strategy for epidermal growth factor receptor-mutated non-small cell lung cancer2023
- Author(s)
  Yu Q, Kobayashi SS, Haeno H
- Journal Title
  
  Front Oncol
  
  Volume: 13:1137966
- DOI
  10.3389/fonc.2023.1137966
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KJ0768, KAKENHI-PROJECT-22H04925
[Journal Article] Stochastic Evolution of Pancreatic Cancer Metastases During Logistic Clonal Expansion2019
- Author(s)
  Yamamoto Kimiyo N.、Liu Lin L.、Nakamura Akira、Haeno Hiroshi、Michor Franziska
- Journal Title
  
  JCO Clinical Cancer Informatics
  
  Volume: 3 Issue: 3 Pages: 1-11
- DOI
  10.1200/cci.18.00079
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26115006, KAKENHI-PROJECT-19K09230
[Journal Article] Computational modeling of pancreatic cancer patients receiving FOLFIRINOX and gemcitabine-based therapies identifies optimum intervention strategies2019
- Author(s)
  Yamamoto Kimiyo N.、Nakamura Akira、Liu Lin L.、Stein Shayna、Tramontano Angela C.、Kartoun Uri、Shimizu Tetsunosuke、Inoue Yoshihiro、Asakuma Mitsuhiro、Haeno Hiroshi、Kong Chung Yin、Uchiyama Kazuhisa、Gonen Mithat、Hur Chin、Michor Franziska
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Issue: 4 Pages: e0215409-e0215409
- DOI
  10.1371/journal.pone.0215409
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26115006, KAKENHI-PROJECT-19K09230
[Journal Article] Mathematical modeling identifies optimum lapatinib dosing schedules for the treatment of glioblastoma patients2018
- Author(s)
  Stein Shayna、Zhao Rui、Haeno Hiroshi、Vivanco Igor、Michor Franziska
- Journal Title
  
  PLOS Computational Biology
  
  Volume: 14 Issue: 1 Pages: e1005924-e1005924
- DOI
  10.1371/journal.pcbi.1005924
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26115006, KAKENHI-PROJECT-16K10584
[Journal Article] Personalized Management of Pancreatic Ductal Adenocarcinoma Patients through Computational Modeling.2017
- Author(s)
  Yamamoto KN, Yachida S, Nakamura A, Niida A, Oshima M, De S, Rosati LM, Herman JM, Iacobuzio-Donahue CA, Haeno H.
- Journal Title
  
  Cancer Res.
  
  Volume: 77 Issue: 12 Pages: 3325-3335
- DOI
  10.1158/0008-5472.can-16-1208
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10584, KAKENHI-PLANNED-26115006, KAKENHI-PUBLICLY-16H01580
[Journal Article] Personalized Management of Pancreatic Ductal Adenocarcinoma Patients Through Computational Modeling.2017
- Author(s)
  1.Yamamoto KN, Yachida S, Nakamura A, Niida A, Oshima M, De S, Rosati LM, Herman JM, Iacobuzio-Donahue CA, Haeno H
- Journal Title
  
  Cancer Research
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26115006
[Journal Article] Personalized Management of Pancreatic Ductal Adenocarcinoma Patients Through Computational Modeling2017
- Author(s)
  Kimiyo N Yamamoto, Shinichi Yachida, Akira Nakamura, Atsushi Niida, Minoru Oshima, Subhajyoti De, Lauren M Rosati, Joseph M. Herman, Christine A Iacobuzio-Donahue and Hiroshi Haeno
- Journal Title
  
  Cancer research
  
  Volume: ―
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10584
[Journal Article] Prediction of postoperative liver regeneration from clinical information using a data-led mathematical model.2016
- Author(s)
  Yamamoto KN Ishii M, Inoue Y, Hirokawa F, MacArthur BD, Nakamura A, Haeno H, Uchiyama K.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 34214-34214
- DOI
  10.1038/srep34214
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26115006, KAKENHI-PROJECT-16K10584
[Journal Article] Integrated Multiregional Analysis Proposing a New Model of Colorectal Cancer Evolution.2016
- Author(s)
  Uchi R, Takahashi Y, Niida A, Shimamura T, Hirata H, Sugimachi K, Sawada G, Iwaya T, Kurashige J, Shinden Y, Iguchi T, Eguchi H, Chiba K, Shiraishi Y, Nagae G, Yoshida K, Nagata Y, Haeno H et al.
- Journal Title
  
  PLoS Genetics
  
  Volume: 12
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26115006
[Journal Article] Bacterial c-di-GMP affects hematopoietic stem/progenitors and their niches through STING.2015
- Author(s)
  Kobayashi H, Kobayashi CI, Nakamura-Ishizu A, Karigane D, Haeno H, Yamamoto KN, Sato T, Ohteki T, Hayakawa Y, Barber GN, Kurokawa M, Suda T, and Takubo K.
- Journal Title
  
  Cell Reports
  
  Volume: 111 Issue: 1 Pages: 71-84
- DOI
  10.1016/j.celrep.2015.02.066
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15150, KAKENHI-PUBLICLY-15H01485, KAKENHI-PUBLICLY-15H01508, KAKENHI-ORGANIZER-26115001, KAKENHI-PLANNED-26115005, KAKENHI-PROJECT-26221309, KAKENHI-PROJECT-26253029, KAKENHI-PROJECT-15H04861, KAKENHI-PROJECT-24350087, KAKENHI-PLANNED-26115006
[Journal Article] The evolution of tumor metastasis during clonal expansion with alterations in metastasis driver genes2015
- Author(s)
  Yamamoto KN, Nakamura A, Haeno H.
- Journal Title
  
  Sci Rep
  
  Volume: 30:5 Issue: 1 Pages: 15886-15886
- DOI
  10.1038/srep15886
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-26115001, KAKENHI-PLANNED-26115006
[Journal Article] がん進展過程における薬剤耐性獲得の数理モデル2014
- Author(s)
  波江野洋, 山本君代
- Journal Title
  
  がん分子標的薬治療
  
  Volume: 12 Pages: 72-77
- Data Source
  KAKENHI-PROJECT-25891019
[Journal Article] がん進展過程における薬剤耐性獲得の数理モデル2014
- Author(s)
  波江野洋、山本君代
- Journal Title
  
  がん分子標的薬治療
  
  Volume: 12 Pages: 72-77
- Data Source
  KAKENHI-PLANNED-26115006
[Journal Article] Evolution of Pre-Existing versus Acquired Resistance to Platinum Drugs and PARP Inhibitors in BRCA-Associated Cancers2014
- Author(s)
  Kimiyo N Yamamoto, Kouji Hirota, Shunichi Takeda, Hiroshi Haeno
- Journal Title
  
  PLoS One
  
  Volume: 9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25891019
[Journal Article] Evolution of Pre-Existing versus Acquired Resistance to Platinum Drugs and PARP Inhibitors in BRCA Associated Cancers2014
- Author(s)
  Kimiyo N Yamamoto, Kouji Hirota, Shunichi Takeda, Hiroshi Haeno
- Journal Title
  
  PLoS One
  
  Volume: 9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26115006
[Journal Article] がんにおける突然変異蓄積過程の数理モデル解析2014
- Author(s)
  波江野洋、山本君代
- Journal Title
  
  実験医学増刊
  
  Volume: 32 Pages: 208-213
- Data Source
  KAKENHI-PLANNED-26115006
[Journal Article] がんにおける突然変異蓄積過程の数理モデル解析2014
- Author(s)
  波江野洋, 山本君代
- Journal Title
  
  実験医学増刊
  
  Volume: 32 Pages: 208-213
- Data Source
  KAKENHI-PROJECT-25891019
[Presentation] Computational modeling of colorectal cancer initiation and recurrence based on public recurrence data2023
- Author(s)
  Hiroshi Haeno
- Organizer
  The 8th China-India-Japan-Korea Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H04925
[Presentation] Mathematical Analysis of Tumor Immune Escape in Colorectal Cancer2022
- Author(s)
  Hiroshi Haeno
- Organizer
  第２回ASHBi 数理ヒト生物学研究会（Mathhub 2022)
- Invited
- Data Source
  KAKENHI-PROJECT-22H04925
[Presentation] Computational modeling identifies optimal use of EGFR tyrosine kinase inhibitors for lung cancer patients with EGFR mutations2019
- Author(s)
  Hiroshi Haeno
- Organizer
  11th AACR-JCA Joint Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26115006
[Presentation] 個別化治療に向けた膵癌進展の数理モデル研究2018
- Author(s)
  波江野洋
- Organizer
  第２９回日本消化器がん発生学会
- Data Source
  KAKENHI-PLANNED-26115006
[Presentation] データを用いたがんの数理モデル研究2018
- Author(s)
  波江野洋
- Organizer
  第１５回生物数学の理論とその応用
- Data Source
  KAKENHI-PLANNED-26115006
[Presentation] Personalized Management of Pancreatic Ductal Adenocarcinoma Patients Through Computational Modeling2017
- Author(s)
  波江野洋
- Organizer
  日本数理生物学会
- Data Source
  KAKENHI-PLANNED-26115006
[Presentation] Mathematical modeling of cancer and Cancer evolution2016
- Author(s)
  Hiroshi Haeno
- Organizer
  2016 Japanese Society for Mathematical Biology annual meeting
- Place of Presentation
  九州大学
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26115006
[Presentation] 膵がん進行の数理モデル解析2016
- Author(s)
  波江野洋
- Organizer
  生命医薬情報学連合大会
- Place of Presentation
  東京国際交流館プラザ平成
- Data Source
  KAKENHI-PLANNED-26115006
[Presentation] Mathematical modeling of telomere length attrition in hematopoietic tissue2015
- Author(s)
  Hiroshi Haeno, Honda Haruki
- Organizer
  2015 Joint Meeting of The 5th China-Japan-Korea Colloquium on Mathematical Biology and The Japanese Society for Mathematical Biology
- Place of Presentation
  日本・京都
- Year and Date
  2015-08-26
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26115006
[Presentation] Mathematical analysis on the genetic evolution from primary to metastatic tumor2015
- Author(s)
  Hiroshi Haeno, Kimiyo N. Yamamoto, Subhajyoti De
- Organizer
  The 74th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  日本・名古屋
- Year and Date
  2015-10-08
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26115006
[Presentation] Mathematical analysis on the genetic evolution from primary to metastatic tumor2014
- Author(s)
  波江野洋、Subhojyoti De
- Organizer
  日本消化器癌学会
- Place of Presentation
  日本・福岡
- Year and Date
  2014-11-13
- Data Source
  KAKENHI-PLANNED-26115006
[Presentation] Genetic Evolution from primary to metastatic tumor2014
- Author(s)
  Hiroshi Haeno, Subhojyoti De
- Organizer
  Annual Meeting of the Japanese Society for Mathematical Biology and the Society for Mathematical Biology
- Place of Presentation
  日本・大阪
- Year and Date
  2014-07-28
- Data Source
  KAKENHI-PLANNED-26115006
[Presentation] Stochastic tunneling of two mutations in a population of cancer cells
- Author(s)
  Hiroshi Haeno, Yosef. E. Maruvka, Yoh Iwasa, Franziska Michor
- Organizer
  9th European Conference on Mathematical and Theoretical Biology
- Place of Presentation
  スウェーデン・ヨーテボリ
- Year and Date
  2014-06-15 – 2014-06-20
- Data Source
  KAKENHI-PROJECT-25891019
[Presentation] Genetic evolution from primary to metastatic tumor
- Author(s)
  Hiroshi Haeno, Subhajyoti De
- Organizer
  Joint Annual Meeting of the Japanese Society for Mathematical Biology and the Society for Mathematical Biology
- Place of Presentation
  日本・大阪
- Year and Date
  2014-07-28 – 2014-08-01
- Data Source
  KAKENHI-PROJECT-25891019

1. Iwama Atsushi (70244126)

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10. Takizawa Hitoshi (10630866)

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29. 笠原雅弘 (60376605)

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30. 中谷明弘 (60301149)

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31. 伊藤武彦 (90501106)

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32. 山田拓司 (10437262)

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33. 高橋弘喜 (60548460)

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35. 瀬々潤 (40361539)

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36. 平川英樹 (80372746)

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37. 島村徹平 (00623943)

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38. 熊谷雄太郎 (00528408)

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39. 林哲也 (10173014)

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40. 岩崎渉 (50545019)

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41. Suda Toshio

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42. Hara Eiji

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43. INOUE Yoshihiro

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44. ISHII Masatsugu

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45. NAKAMURA Akira

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46. Ho Anthony

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47. Michor Franziska

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48. MacArthur Ben D.

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49. Hur Chin

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50. MIZUNO Shinichi

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51. 樗木俊聡

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52. Yu Qian

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Haeno Hiroshi 波江野 洋

HAENO HIROSHI 波江野 洋

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無病生存期間データと数理モデルを用いた組織特異的発がんプロセスの網羅解析Principal Investigator

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Mathematical analysis of the mechanism of cancer initiation with the aging of stem cellsPrincipal Investigator

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造血組織における多様な発がん過程の網羅的シミュレーション解析Principal Investigator

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[Book] 実験医学増刊2017

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[Journal Article] がんの免疫逃避進化のシミュレーションモデル研究2024

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[Journal Article] Subclonal accumulation of immune escape mechanisms in microsatellite instability-high colorectal cancers2023

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[Journal Article] Computational modeling of locoregional recurrence with spatial structure identifies tissue-specific carcinogenic profiles2023

Haeno Hiroshi 波江野洋

HAENO HIROSHI 波江野洋