iwasaki masayuki 岩崎正幸

… Alternative Names

Iwasaki Masayuki 岩崎正幸

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Researcher Number	70790913
Other IDs
Affiliation (Current)	2025: 東京女子医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2018 – 2024: 東京女子医科大学, 医学部, 講師 2017: 熊本大学, 国際先端医学研究機構, 客員准教授
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Basic Section 54010:Hematology and medical oncology-related / Tumor biology Except Principal Investigator Basic Section 50010:Tumor biology-related / Basic Section 49030:Experimental pathology-related / Medium-sized Section 50:Oncology and related fields / Medium-sized Section 49:Pathology, infection/immunology, and related fields
Keywords	Principal Investigator 白血病幹細胞 / Meis1 / Hox / 急性骨髄性白血病 / エピジェネティクス / 骨髄異形成症候群 / 造血器腫瘍 / IBD / UTX / 自己免疫疾患 … More / MLL / HOX / MEIS1 / 15-PGDH … More Except Principal Investigator 細胞周期 / 細胞動態 / 白血病幹細胞 / RUNX / 分子標的治療 / 白血病 / 分指標的治療 / マウスモデ / マウスモデル / AYA世代がん / 単細胞遺伝子発現解析 / 細胞移動 / In situ光ラベリング / 急性骨髄性白血病 / 急性転化 / 慢性骨髄性白血病 / 抗加齢療法 / 老化 / 幹細胞 / ヒストン修飾 / ヒストンメチル化・脱メチル化 / UTY / UTX / ヒストン脱メチル化 / エピジェネティクス / Uty / 幹細胞老化 / ヒストン脱メチル化酵素 / Utx / 癌 / がん幹細胞 / 抗体医薬 / ITGA9 / トランスレーショナルリサーチ Less

Hox関連白血病におけるDnajc10による白血病幹細胞制御機構の解明Principal Investigator
- Principal Investigator
  
  岩崎正幸
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tokyo Women's Medical University
Identification of novel therapeutic target molecules based on correlation between leukemia stem cell heterogeneity and in vivo dynamics
- Principal Investigator
  
  戸村道夫
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Osaka Ohtani University
Elucidation of the molecular basis for age-dependent leukemogenesis towards a novel therapeutic strategy
- Principal Investigator
  
  大里元美
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kumamoto University
ヒストン修飾因子に注目した骨髄異形成症候群と自己免疫疾患の共通分子基盤の解明Principal Investigator
- Principal Investigator
  
  岩崎正幸
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tokyo Women's Medical University
Elucidation of in vivo kinetics of leukemia cell differentiation and proliferation in blast crisis
- Principal Investigator
  
  戸村道夫
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Osaka Ohtani University
Development of novel antibodies against leukemia and elucidation of their blocking mechanisms
- Principal Investigator
  
  Osato Motomi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kumamoto University
Elucidation of mechanisms underlying stem cell aging induced by deregulation of histone modifications and development of anti-aging therapies by maintaining their functions
- Principal Investigator
  
  HONDA HIROAKI
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Tokyo Women's Medical University
15-PGDH regulates leukemia stem cell potential in HOX-associated myeloid leukemiaPrincipal Investigator
- Principal Investigator
  
  Iwasaki Masayuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Tokyo Women's Medical University
  Kumamoto University

All 2023 2022 2021 2019 2018 2017

All Journal Article Presentation Book

[Book] MLL遺伝子再構成陽性急性骨髄性白血病幹細胞におけるCD93の発現（血液内科）2017
- Author(s)
  岩崎正幸
- Total Pages
  6
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-17H03579
[Journal Article] MBTD1 preserves adult hematopoietic stem cell pool size and function2023
- Author(s)
  Takubo Keiyo、Htun Phyo Wai、Ueda Takeshi、Sera Yasuyuki、Iwasaki Masayuki、Koizumi Miho、Shiroshita Kohei、Kobayashi Hiroshi、Haraguchi Miho、Watanuki Shintaro、Honda Zen-ichiro、Yamasaki Norimasa、Nakamura-Ishizu Ayako、Arai Fumio、Motoyama Noboru、Hatta Tomohisa、Natsume Tohru、Suda Toshio、Honda Hiroaki
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 120 Issue: 32
- DOI
  10.1073/pnas.2206860120
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16333, KAKENHI-PROJECT-21K08378, KAKENHI-PROJECT-23K07134, KAKENHI-PROJECT-21K08431, KAKENHI-PROJECT-22K19550, KAKENHI-PROJECT-21H02957, KAKENHI-PROJECT-23K27442
[Journal Article] Enhancer remodeling drives MLL oncogene-dependent transcriptional dysregulation in leukemia stem cells2023
- Author(s)
  Pan Feng、Iwasaki Masayuki、Wu Wenqi、Jiang Yanan、Yang Xin、Zhu Li、Zhao Zhigang、Cleary Michael L.
- Journal Title
  
  Blood Advances
  
  Volume: 7 Issue: 11 Pages: 2504-2519
- DOI
  10.1182/bloodadvances.2022008787
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08378
[Journal Article] UTX deficiency in neural stem/progenitor cells results in impaired neural development, fetal ventriculomegaly, and postnatal death2022
- Author(s)
  Koizumi M, Eto H, Saeki M, Seki M, Fukushima T, Mukai S, Ide H, Sera Y, Iwasaki M, Suzuki Y, Tohei A, Kishi Y, Honda H.
- Journal Title
  
  FASEB journal
  
  Volume: 36(12) Issue: 12 Pages: 22662-22662
- DOI
  10.1096/fj.202201002rr
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08378, KAKENHI-PROJECT-22K19823, KAKENHI-PROJECT-22K16333, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-20H03179, KAKENHI-PROJECT-19K17918, KAKENHI-PUBLICLY-21H00242, KAKENHI-PUBLICLY-22H04687
[Journal Article] UTX maintains functional integrity of murine hematopoietic system by globally regulating aging-associated genes.2021
- Author(s)
  Sera Y; Nakata Y; Ueda T; Yamasaki N; Koide S; Kobayashi H; Ikeda KI; Kobatake K; Iwasaki M; Oda H; Wolff L; Kanai A; Nagamachi A; Inaba T; Sotomaru Y; Ichinohe T; Koizumi M; Miyakawa Y; Honda ZI; Iwama A; Suda T; Takubo K; Honda H
- Journal Title
  
  Blood.
  
  Volume: 137 Issue: 7 Pages: 908-922
- DOI
  10.1182/blood.2019001044
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07346, KAKENHI-PROJECT-19K22546, KAKENHI-PROJECT-19K17918, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-18H02845, KAKENHI-PROJECT-19H03693, KAKENHI-PROJECT-18K08357, KAKENHI-PROJECT-18K18196, KAKENHI-PROJECT-19K17847, KAKENHI-PROJECT-19H01056, KAKENHI-PROJECT-18H05284, KAKENHI-PROJECT-21K08378, KAKENHI-PROJECT-21K08395
[Journal Article] High-efficiency CRISPR induction of t(9;11) chromosomal translocations and acute leukemias in human blood stem cells2019
- Author(s)
  Jeong Johan、Jager Astraea、Domizi Pablo、Pavel-Dinu Mara、Gojenola Linda、Iwasaki Masayuki、Wei Michael C.、Pan Feng、Zehnder James L.、Porteus Matthew H.、Davis Kara L.、Cleary Michael L.
- Journal Title
  
  Blood Advances
  
  Volume: 3 Issue: 19 Pages: 2825-2835
- DOI
  10.1182/bloodadvances.2019000450
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03579
[Journal Article] MicroRNA-127-3p controls murine hematopoietic stem cell maintenance by limiting differentiation2019
- Author(s)
  Crisafulli Laura、Muggeo Sharon、Uva Paolo、Wang Yulei、Iwasaki Masayuki、Locatelli Silvia、Anselmo Achille、Colombo Federico S.、Carlo-Stella Carmelo、Cleary Michael L.、Villa Anna、Gentner Bernhard、Ficara Francesca
- Journal Title
  
  Haematologica
  
  Volume: 104 Issue: 9 Pages: 1744-1755
- DOI
  10.3324/haematol.2018.198499
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03579
[Journal Article] MLL leukemia induction by t(9;11) chromosomal translocation in human hematopoietic stem cells using genome editing2018
- Author(s)
  Schneidawind Corina、Jeong Johan、Schneidawind Dominik、Kim In-Suk、Duque-Afonso Jesus、Wong Stephen Hon Kit、Iwasaki Masayuki、Breese Erin H.、Zehnder James L.、Porteus Matthew、Cleary Michael L.
- Journal Title
  
  Blood Advances
  
  Volume: 2 Issue: 8 Pages: 832-845
- DOI
  10.1182/bloodadvances.2017013748
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03579
[Presentation] ヒストン修飾因子UTXは老化関連遺伝子を制御することにより造血系維持に関与する2021
- Author(s)
  世良康如, 中田雄一郎, 上田健, 山崎憲政, 小出周平, 小林央, 池田健一郎, 小畠浩平, 岩崎正幸, 小田秀明, 金井昭教, 長町安希子, 稲葉俊哉, 外丸祐介, 一戸辰夫, 小泉美穂, 宮川佳彦, 本田善一郎, 岩間厚志, 須田年生, 田久保圭誉, 本田浩章
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K22546
[Presentation] MLL遺伝子再構成を伴う急性骨髄性白血病幹細胞における15－PGDHの役割2019
- Author(s)
  岩崎正幸、本田浩章、大里元美、Michael Cleary
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K22546
[Presentation] Essential non-canonical role for 15-PGDH in HOX-associated leukemia stem cells2019
- Author(s)
  Masayuki Iwasaki
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H03579
[Presentation] Essential non-canonical role for 15-PGDH in MLL-rearranged AML stem cells2019
- Author(s)
  Masayuki Iwasaki
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H03579
[Presentation] MLL遺伝子再構成をを伴う急性骨髄性白血病幹細胞における15-PGDHの役割2017
- Author(s)
  岩崎正幸, Michael Cleary
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H03579

1. Osato Motomi (90314286)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. HONDA HIROAKI (40245064)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
3. 指田吾郎 (70349447)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 戸村道夫 (30314321)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 楠本豊 (40252689)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 山本浩平 (50451927)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 世良康如 (40836532)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 本田善一郎 (70238814)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 守屋大樹 (30759759)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 橋井佳子 (60343258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 橋本茉由子 (60943628)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 横溝智雅 (80590314)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. UEDA Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 金井昭教

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

iwasaki masayuki 岩崎 正幸

Iwasaki Masayuki 岩崎 正幸

Research Projects

Research Products

Co-Researchers

Hox関連白血病におけるDnajc10による白血病幹細胞制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of novel therapeutic target molecules based on correlation between leukemia stem cell heterogeneity and in vivo dynamics

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the molecular basis for age-dependent leukemogenesis towards a novel therapeutic strategy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ヒストン修飾因子に注目した骨髄異形成症候群と自己免疫疾患の共通分子基盤の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of in vivo kinetics of leukemia cell differentiation and proliferation in blast crisis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel antibodies against leukemia and elucidation of their blocking mechanisms

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of mechanisms underlying stem cell aging induced by deregulation of histone modifications and development of anti-aging therapies by maintaining their functions

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

15-PGDH regulates leukemia stem cell potential in HOX-associated myeloid leukemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] MLL遺伝子再構成陽性急性骨髄性白血病幹細胞におけるCD93の発現（血液内科）2017

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] MBTD1 preserves adult hematopoietic stem cell pool size and function2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enhancer remodeling drives MLL oncogene-dependent transcriptional dysregulation in leukemia stem cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] UTX deficiency in neural stem/progenitor cells results in impaired neural development, fetal ventriculomegaly, and postnatal death2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] UTX maintains functional integrity of murine hematopoietic system by globally regulating aging-associated genes.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High-efficiency CRISPR induction of t(9;11) chromosomal translocations and acute leukemias in human blood stem cells2019

Author(s)

iwasaki masayuki 岩崎正幸

Iwasaki Masayuki 岩崎正幸