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iwasaki masayuki  岩崎 正幸

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Iwasaki Masayuki  岩崎 正幸

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Researcher Number 70790913
Other IDs
Affiliation (Current) 2025: 東京女子医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help 2018 – 2024: 東京女子医科大学, 医学部, 講師
2017: 熊本大学, 国際先端医学研究機構, 客員准教授
Review Section/Research Field
Principal Investigator
Basic Section 50010:Tumor biology-related / Basic Section 54010:Hematology and medical oncology-related / Tumor biology
Except Principal Investigator
Basic Section 50010:Tumor biology-related / Basic Section 49030:Experimental pathology-related / Medium-sized Section 50:Oncology and related fields / Medium-sized Section 49:Pathology, infection/immunology, and related fields
Keywords
Principal Investigator
白血病幹細胞 / Meis1 / Hox / 急性骨髄性白血病 / エピジェネティクス / 骨髄異形成症候群 / 造血器腫瘍 / IBD / UTX / 自己免疫疾患 … More / MLL / HOX / MEIS1 / 15-PGDH … More
Except Principal Investigator
細胞周期 / 細胞動態 / 白血病幹細胞 / RUNX / 分子標的治療 / 白血病 / 分指標的治療 / マウスモデ / マウスモデル / AYA世代がん / 単細胞遺伝子発現解析 / 細胞移動 / In situ光ラベリング / 急性骨髄性白血病 / 急性転化 / 慢性骨髄性白血病 / 抗加齢療法 / 老化 / 幹細胞 / ヒストン修飾 / ヒストンメチル化・脱メチル化 / UTY / UTX / ヒストン脱メチル化 / エピジェネティクス / Uty / 幹細胞老化 / ヒストン脱メチル化酵素 / Utx / 癌 / がん幹細胞 / 抗体医薬 / ITGA9 / トランスレーショナルリサーチ Less
  • Research Projects

    (8 results)
  • Research Products

    (13 results)
  • Co-Researchers

    (14 People)
  •  Hox関連白血病におけるDnajc10による白血病幹細胞制御機構の解明Principal Investigator

    • Principal Investigator
      岩崎 正幸
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Tokyo Women's Medical University
  •  Identification of novel therapeutic target molecules based on correlation between leukemia stem cell heterogeneity and in vivo dynamics

    • Principal Investigator
      戸村 道夫
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 49030:Experimental pathology-related
    • Research Institution
      Osaka Ohtani University
  •  Elucidation of the molecular basis for age-dependent leukemogenesis towards a novel therapeutic strategy

    • Principal Investigator
      大里 元美
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Kumamoto University
  •  ヒストン修飾因子に注目した骨髄異形成症候群と自己免疫疾患の共通分子基盤の解明Principal Investigator

    • Principal Investigator
      岩崎 正幸
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Tokyo Women's Medical University
  •  Elucidation of in vivo kinetics of leukemia cell differentiation and proliferation in blast crisis

    • Principal Investigator
      戸村 道夫
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 50:Oncology and related fields
    • Research Institution
      Osaka Ohtani University
  •  Development of novel antibodies against leukemia and elucidation of their blocking mechanisms

    • Principal Investigator
      Osato Motomi
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Kumamoto University
  •  Elucidation of mechanisms underlying stem cell aging induced by deregulation of histone modifications and development of anti-aging therapies by maintaining their functions

    • Principal Investigator
      HONDA HIROAKI
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 49:Pathology, infection/immunology, and related fields
    • Research Institution
      Tokyo Women's Medical University
  •  15-PGDH regulates leukemia stem cell potential in HOX-associated myeloid leukemiaPrincipal Investigator

    • Principal Investigator
      Iwasaki Masayuki
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Tumor biology
    • Research Institution
      Tokyo Women's Medical University
      Kumamoto University

All 2023 2022 2021 2019 2018 2017

All Journal Article Presentation Book

  • [Book] MLL遺伝子再構成陽性急性骨髄性白血病幹細胞におけるCD93の発現(血液内科)2017

    • Author(s)
      岩崎正幸
    • Total Pages
      6
    • Publisher
      科学評論社
    • Data Source
      KAKENHI-PROJECT-17H03579
  • [Journal Article] MBTD1 preserves adult hematopoietic stem cell pool size and function2023

    • Author(s)
      Takubo Keiyo、Htun Phyo Wai、Ueda Takeshi、Sera Yasuyuki、Iwasaki Masayuki、Koizumi Miho、Shiroshita Kohei、Kobayashi Hiroshi、Haraguchi Miho、Watanuki Shintaro、Honda Zen-ichiro、Yamasaki Norimasa、Nakamura-Ishizu Ayako、Arai Fumio、Motoyama Noboru、Hatta Tomohisa、Natsume Tohru、Suda Toshio、Honda Hiroaki
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 120 Issue: 32

    • DOI

      10.1073/pnas.2206860120

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K16333, KAKENHI-PROJECT-21K08378, KAKENHI-PROJECT-23K07134, KAKENHI-PROJECT-21K08431, KAKENHI-PROJECT-22K19550, KAKENHI-PROJECT-21H02957, KAKENHI-PROJECT-23K27442
  • [Journal Article] Enhancer remodeling drives MLL oncogene-dependent transcriptional dysregulation in leukemia stem cells2023

    • Author(s)
      Pan Feng、Iwasaki Masayuki、Wu Wenqi、Jiang Yanan、Yang Xin、Zhu Li、Zhao Zhigang、Cleary Michael L.
    • Journal Title

      Blood Advances

      Volume: 7 Issue: 11 Pages: 2504-2519

    • DOI

      10.1182/bloodadvances.2022008787

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08378
  • [Journal Article] UTX deficiency in neural stem/progenitor cells results in impaired neural development, fetal ventriculomegaly, and postnatal death2022

    • Author(s)
      Koizumi M, Eto H, Saeki M, Seki M, Fukushima T, Mukai S, Ide H, Sera Y, Iwasaki M, Suzuki Y, Tohei A, Kishi Y, Honda H.
    • Journal Title

      FASEB journal

      Volume: 36(12) Issue: 12 Pages: 22662-22662

    • DOI

      10.1096/fj.202201002rr

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K08378, KAKENHI-PROJECT-22K19823, KAKENHI-PROJECT-22K16333, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-20H03179, KAKENHI-PROJECT-19K17918, KAKENHI-PUBLICLY-21H00242, KAKENHI-PUBLICLY-22H04687
  • [Journal Article] UTX maintains functional integrity of murine hematopoietic system by globally regulating aging-associated genes.2021

    • Author(s)
      Sera Y; Nakata Y; Ueda T; Yamasaki N; Koide S; Kobayashi H; Ikeda KI; Kobatake K; Iwasaki M; Oda H; Wolff L; Kanai A; Nagamachi A; Inaba T; Sotomaru Y; Ichinohe T; Koizumi M; Miyakawa Y; Honda ZI; Iwama A; Suda T; Takubo K; Honda H
    • Journal Title

      Blood.

      Volume: 137 Issue: 7 Pages: 908-922

    • DOI

      10.1182/blood.2019001044

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07346, KAKENHI-PROJECT-19K22546, KAKENHI-PROJECT-19K17918, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-18H02845, KAKENHI-PROJECT-19H03693, KAKENHI-PROJECT-18K08357, KAKENHI-PROJECT-18K18196, KAKENHI-PROJECT-19K17847, KAKENHI-PROJECT-19H01056, KAKENHI-PROJECT-18H05284, KAKENHI-PROJECT-21K08378, KAKENHI-PROJECT-21K08395
  • [Journal Article] High-efficiency CRISPR induction of t(9;11) chromosomal translocations and acute leukemias in human blood stem cells2019

    • Author(s)
      Jeong Johan、Jager Astraea、Domizi Pablo、Pavel-Dinu Mara、Gojenola Linda、Iwasaki Masayuki、Wei Michael C.、Pan Feng、Zehnder James L.、Porteus Matthew H.、Davis Kara L.、Cleary Michael L.
    • Journal Title

      Blood Advances

      Volume: 3 Issue: 19 Pages: 2825-2835

    • DOI

      10.1182/bloodadvances.2019000450

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H03579
  • [Journal Article] MicroRNA-127-3p controls murine hematopoietic stem cell maintenance by limiting differentiation2019

    • Author(s)
      Crisafulli Laura、Muggeo Sharon、Uva Paolo、Wang Yulei、Iwasaki Masayuki、Locatelli Silvia、Anselmo Achille、Colombo Federico S.、Carlo-Stella Carmelo、Cleary Michael L.、Villa Anna、Gentner Bernhard、Ficara Francesca
    • Journal Title

      Haematologica

      Volume: 104 Issue: 9 Pages: 1744-1755

    • DOI

      10.3324/haematol.2018.198499

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H03579
  • [Journal Article] MLL leukemia induction by t(9;11) chromosomal translocation in human hematopoietic stem cells using genome editing2018

    • Author(s)
      Schneidawind Corina、Jeong Johan、Schneidawind Dominik、Kim In-Suk、Duque-Afonso Jesus、Wong Stephen Hon Kit、Iwasaki Masayuki、Breese Erin H.、Zehnder James L.、Porteus Matthew、Cleary Michael L.
    • Journal Title

      Blood Advances

      Volume: 2 Issue: 8 Pages: 832-845

    • DOI

      10.1182/bloodadvances.2017013748

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H03579
  • [Presentation] ヒストン修飾因子UTXは老化関連遺伝子を制御することにより造血系維持に関与する2021

    • Author(s)
      世良康如, 中田雄一郎, 上田健, 山崎憲政, 小出周平, 小林央, 池田健一郎, 小畠浩平, 岩崎正幸, 小田秀明, 金井昭教, 長町安希子, 稲葉俊哉, 外丸祐介, 一戸辰夫, 小泉美穂, 宮川佳彦, 本田善一郎, 岩間厚志, 須田年生, 田久保圭誉, 本田浩章
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-19K22546
  • [Presentation] MLL遺伝子再構成を伴う急性骨髄性白血病幹細胞における15-PGDHの役割2019

    • Author(s)
      岩崎正幸、本田浩章、大里元美、Michael Cleary
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K22546
  • [Presentation] Essential non-canonical role for 15-PGDH in HOX-associated leukemia stem cells2019

    • Author(s)
      Masayuki Iwasaki
    • Organizer
      第81回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-17H03579
  • [Presentation] Essential non-canonical role for 15-PGDH in MLL-rearranged AML stem cells2019

    • Author(s)
      Masayuki Iwasaki
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-17H03579
  • [Presentation] MLL遺伝子再構成をを伴う急性骨髄性白血病幹細胞における15-PGDHの役割2017

    • Author(s)
      岩崎正幸, Michael Cleary
    • Organizer
      第79回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-17H03579
  • 1.  Osato Motomi (90314286)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 2.  HONDA HIROAKI (40245064)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 3 results
  • 3.  指田 吾郎 (70349447)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  戸村 道夫 (30314321)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  楠本 豊 (40252689)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  山本 浩平 (50451927)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  世良 康如 (40836532)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 8.  本田 善一郎 (70238814)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 9.  守屋 大樹 (30759759)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  橋井 佳子 (60343258)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  橋本 茉由子 (60943628)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  横溝 智雅 (80590314)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  UEDA Takeshi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  金井 昭教
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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