MATUNO Seiki 松野正紀

Researcher Number	80004737
External Links
Affiliation (based on the past Project Information) *help	2004: 国立大学法人東北大学, 大学院・医学研究院, 教授 1999 – 2004: Tohoku University, School of Medicine, First Department of Surgery, Professor, 大学院・医学系研究科, 教授 1988 – 2001: 東北大学, 医学部, 教授 1987: Tohoku Univensity School of Medicire, subprofessor, 医学部, 助教授
Review Section/Research Field	Principal Investigator Digestive surgery / Digestive surgery Except Principal Investigator Digestive surgery / General surgery / Biological Sciences / Digestive surgery
Keywords	Principal Investigator 膵癌 / 消化管運動 / LAK / NK活性 / 肝転移 / 抗癌剤感受性 / chenodeoxycholate / pancreatic cancer / 18q / 17p … More / 12q / 6q / 磁性流体 / IL-12 / Th1 / LFA-1 / ICAM-1 / 血管新生 / ラ島移植 / adoptive immunotherapy / NK / human pancreatic cancer cells / liver metastasis / 人膵癌培養細胞 / BRM / ヌードマウス肝転移モデル / EBvirus / 単クロ-ン抗体 / ヌ-ドマウス肝転移モデル / 人膵癌細胞 / 養子免疫 / LAK活性 / 膵癌細胞 / liposome / sousitinty to anti-tumor drugs / platelet aggregation inhibition / fibrorectin / NK activity / pahcreatic liver metastasis / プロスタグランジン / targeting chemotherapy / リポソーム / 血小板凝集阻害 / フィブロネクチン / cyclooxygenase-2 / methotrexate / gastrointestinal cancer / transcriptional factor / transporter / bile acid / LST-2 / LST-1 / 肝臓 / 消火器癌 / ケノデオキシコール酸 / COX-2 / メトトレキセート / 消化器癌 / 転写調節 / トランスポーター / 胆汁酸 / silica / Felstar magnetic filed / Magnetic fluid / 胃掛出 / フェルスター磁界 / シリカ / フエルスター磁界 / angiogenesis / gene therapy / tumor suppressor gene / FISH / CGH / LOH / 染色体異常 / 遺伝子異常 / 早期診断 / 診療システム / 遺伝子治療 / 癌抑制遺伝子 / gastric empting / magnetic fluid / 胃排出 / Th2 balance / islet transplantation / hybrid pancreas / xenograft transplantation / growth factor / costimulatory signal / セルロース / 膵移植 / ハイブリッド型人工膵 / Th2バランス / ラ氏島移植 / ハイブリッド型人工膵臓 / VEGF / アデノウイルス / p300 / HIF / E1A / 転写因子 / PDX-1 / グルカゴン / インスリン / 膵ラ島 / マイクロアレイ / インシュリン産生細胞 / ES細胞 / 膵管上皮細胞 / 筋細胞 / インピーダンススペクトロスコピー / 空腸肛門吻合 / 消化管筋電図 / バロスタット / J型空腸嚢 / J型回腸嚢 / 回腸肛門吻合術 / 大腸全摘術 … More Except Principal Investigator 膵癌 / 遺伝子治療 / laparoscopic surgery / cancer / SNP / gastric cancer / SART-3 / SART-2 / SART-1 / CTL / HLA / 血管新生 / 5FU / gene therapy / pancreatic cancer / P53遺伝子 / 癌 / マイクロサテライトマーカー / DNA多型マーカー / 罹患同胞対法 / 連鎖解析 / 胃がん / Laparoscopic Surgery / microarray analysis / PDX-1 gene / pancreatic islet regeneration / insulin secreting cell / pancreatic ductal epithelium / 膵再生 / PDX-1 / angiopoietin / VEGF / 膵ラ島 / マイクロアレイ / PDX1 / ラ島 / 膵管上皮細胞 / マイクロアレイ解析 / PDX-1遺伝子 / 膵ラ島再生 / インシュリン産生細胞 / 膵管上皮細 / CBI receptor antagonist / anandamide / cannabinoid / Acute pancreatitis / TNF-alpha / サイトカイン / ショック / CB1受容体拮抗薬 / アナンダマイド / カンナビノイド / 急性膵炎 / microsatellite / association / linkage / polymorphism / genome / LOD値 / 全ゲノムスクリーニング / 多因子疾患 / SNPs / 全ゲノムスキャン / 相関 / 連鎖 / 罹患同胞対 / マイクロサテライト / 相関解析 / 遺伝子多型 / ゲノム / cancer vaccine / tumor rejection antigen / 癌ワクチン / 癌拒絶抗原 / 胃癌 / flt 1 / soluble VEGF receptor / angiogenesis / uracil phosphoribosyl transferase / UPRT遺伝子 / 変異型アデノウィルスベクター / 増殖型アテツウイルス / UPRT,CD, / UPRT / アデイウイルス / ハイブリッド型リポソームベクター / fltJ / 可溶性VEGF受容体 / urasyl phospholiposyl transterare / tumor vaccine / transfection efficiency / immunogene therapy / suicede gene / カチオニックリボソーム / 腫瘍ワクチン / 遺伝子導入効率 / 遺伝子免疫療法 / 自殺遺伝子 / 多臓器癌 / IPMT / RB遺伝子 / アデノウイルス / 遺伝要因 / 発がん / 全ゲノムスキャニング / がん遺伝子 Less

IPMT(膵管内乳頭状粘液性腫瘍)DNA多型解析のための発癌と遺伝要因調査
- Principal Investigator
  
  田中雅夫
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
多機能ウイルス遺伝子EIAを用いた転写因子制御の膵癌転移抑制療法Principal Investigator
- Principal Investigator
  
  砂村眞琴, 松野正紀
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University
Tissue Engineering技術を応用したブタ新生児膵ラ島の分化誘導Principal Investigator
- Principal Investigator
  
  松野正紀
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University
Induction of insulin secreting cell and its application for transplantation
- Principal Investigator
  
  SUNAMURA Makoto
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Tohoku University
Develpoment of Diagnositic System for Cancer Metastases Utilizing Fluoroscopic Endoscope
- Principal Investigator
  
  FUKUYAMA Shoji
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University
New Frontiers of Bile Acid Research -Act as a Transcriptional factor for Liver and Gastrointestinal cancers-Principal Investigator
- Principal Investigator
  
  MATSUNO Seiki
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University
A new thrapy for severe acute pancreatitis by regulating the cannabinoid
- Principal Investigator
  
  TAKEDA Kazunori
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University
多彩な遺伝子異常に対応可能な風邪ウイルスを用いた癌の治療
- Principal Investigator
  
  SUNAMURA Makoto
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University
Genome-wide analyses to identify genes involved in gastric cancer
- Principal Investigator
  
  SASAZUKI Tekehiko
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  International Medical Center of Japan
  Kyushu University
罹患同胞対法を用いた胃がん関連遺伝子の解明
- Principal Investigator
  
  SASAZUKI Tekehiko
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyushu University
インピーダンススペクトロスコピー法を用いた全く新しい消化管運動機能測定法の開発Principal Investigator
- Principal Investigator
  
  松野正紀
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University
Development of system to measure GI motility and morphology utilizing improved magnetic fluid.Principal Investigator
- Principal Investigator
  
  MATSUNO Seiki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University
Establishment of novel efficient methods for pancreatic cancer patients based on genetic abnormality.Principal Investigator
- Principal Investigator
  
  MATSUNO Seiki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku Uniersity
Adjuvant gene therapy for pancreatic cancer using hybrid type liposome vector
- Principal Investigator
  
  SUNAMURA Makoto, 小針雅男
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University
Identification of a gene coding for a gastric caicinoman an tigen and develop of a pepticle vaecinefor the tieatment o patnents gostrica
- Principal Investigator
  
  SHIIBA Ken-ichi
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University
大腸全摘術後のQOLの向上をめざした空腸肛門吻合術の有用性の検証と臨床応用Principal Investigator
- Principal Investigator
  
  松野正紀
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University
Suicide gene therapy and tumor specific CTL activated by B7 gene transfected tumor cells against pancretic cancer.
- Principal Investigator
  
  KOBARI Masao
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University
Establishment of a novel method to measure gastrointestinal motility using magnetic fluid.Principal Investigator
- Principal Investigator
  
  MATSUNO Seiki
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University
The treatment for diabetes mellitus after surgery using artificial hybrid pancreasPrincipal Investigator
- Principal Investigator
  
  MATUNO Seiki
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University
Combined modality therapy for pancreatic cancer by targeting chemotherapy and LAK adoptive immunotherapyPrincipal Investigator
- Principal Investigator
  
  MATSUNO Seiki
- Project Period (FY)
  1988 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University
Research for mechanism clarification and prevention of micro-liub-mitastasis in pahcreatic cancerPrincipal Investigator
- Principal Investigator
  
  SEIKI Matsuho, 宮川菊雄
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  TOHOKU UNIVERSITY

All 2005 2004 2003 2002 2000 1999

All Journal Article

[Journal Article] 制限増殖型アデノウイルスによる癌治療2005
- Author(s)
  元井冬彦, 松野正紀
- Journal Title
  
  Surgery Frontier 12・1
  
  Pages: 26-33
- Data Source
  KAKENHI-PROJECT-16659349
[Journal Article] Oncolytic Virotherapy as a Novel Strategy for Pancreatic Cancer.2004
- Author(s)
  Sunamura M S, Matsuno S
- Journal Title
  
  Pancreas 28・3
  
  Pages: 326-329
- NAID
  10016168584
- Data Source
  KAKENHI-PROJECT-16659349
[Journal Article] 膵癌膵癌の早期診断の進め方2004
- Author(s)
  福山尚治, 武田和憲, 江川新一, 砂村眞琴, 松野正紀
- Journal Title
  
  肝・胆・膵 47(3)
  
  Pages: 327-334
- Data Source
  KAKENHI-PROJECT-14370372
[Journal Article] 疾患別にみた手術適応とタイミングの判断2004
- Author(s)
  福山尚治, 武田和憲, 江川新一, 砂村眞琴, 松野正紀
- Journal Title
  
  救急医学 28(1)
  
  Pages: 82-90
- Data Source
  KAKENHI-PROJECT-14370372
[Journal Article] Feasibility of Robotic-assisted Laparoscopic Pancreaticojejunostomy2003
- Author(s)
  Fukuyama S, Shibuya K, Egawa S, Sunamura M, Takeda, Matsuno S, Gagner M
- Journal Title
  
  J JCAS 5(3)
  
  Pages: 201-202
- NAID
  10025681641
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370372
[Journal Article] Control of immuno-rejection for islet transplantation and the application of regeneration medicine.2002
- Author(s)
  Sunamura M, Matsuno S, et al.
- Journal Title
  
  Journal of Japanese Society of Apheresis 21,2
  
  Pages: 132-140
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370346
[Journal Article] 膵ラ島移植における拒絶反応と再生医療の応用2002
- Author(s)
  砂村眞琴, 松野正紀, 他
- Journal Title
  
  日本アフェレシス学会誌 21・2
  
  Pages: 132-140
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370346
[Journal Article] Effect of intraportal adoptive immunotherapy on liver metastases after resection of pancreatic cancer.2000
- Author(s)
  Kobari, M., Egawa, S., Shibuya, K., Sunamura, M., Saitoh, K., Matsuno, S.
- Journal Title
  
  Br.J.Surg. 87
  
  Pages: 43-48
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10307032
[Journal Article] Effective gene therapy for pancreatic cancer by cytokines mediated by restricted replication-competent adenovirus.2000
- Author(s)
  Motoi, F., Sunamura, M., Ding, L., Yoshida, Y., Matsuno, S., Hamada, H.
- Journal Title
  
  Hum.Gene Ther. 11
  
  Pages: 223-235
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10307032
[Journal Article] Direct in vitro evidence and in vivo analysis of the anti-angiogenesis effects of interleukin 12.2000
- Author(s)
  Duda, D.G., Sunamura, M., Lozonschi, L., Kodama, T., Egawa, S., Matsumoto, G., Shimamura, H., Shibuya, K., Takeda, K., Matsuno, S.
- Journal Title
  
  Cancer Res. 60
  
  Pages: 1111-1116
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10307032
[Journal Article] Controlling tumor angiogenesis and metastasis of C26 murin colon adenocarcinoma by a new matrix metalloproteinase inhibitor, KB-R7785, in two tumor models.1999
- Author(s)
  Lozonschi L., Sunamura M., Kobari M., Egawa S., Ding L., Matsuno S.
- Journal Title
  
  Cancer Res. 59
  
  Pages: 1252-1258
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10307032
[Journal Article] Infrequent somatic mutations of the p73 gene in various human cancers.1999
- Author(s)
  Han, S., Semba, S., Abe, T., Makino, N., Furukawa, T., Fukushige, S., Takahashi, H., Sakurada, A., Sato, M., Shiiba, K., Matsuno, S., Nimura, Y., Nakagawara, A., Horii, A.
- Journal Title
  
  Eur.J.Surg.Oncol. 25
  
  Pages: 194-198
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10307032
[Journal Article] Intraductal papillary mucinous tumors of the pancreas comprise 2 clinical subtypes.1999
- Author(s)
  Kobari, M., Egawa, S., Shibuya K., Shimamura, H., Sunamura, M., Takeda, K., Matsuno, S.
- Journal Title
  
  Arch.Surg. 134
  
  Pages: 1131-1136
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10307032
[Journal Article] Genomic analysis of the thymine-DNA glycosylase (TDG) gene on 12q22-q24.1 in human pancreatic ductal adenocarcinoma.1999
- Author(s)
  Yatsuoka, T., Furukawa, T., Abe, T., Yokoyama, T., Sunamura, M., Kobari, M., Matsuno, S., Horii, A.
- Journal Title
  
  Int.J.Panc. 25
  
  Pages: 97-102
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10307032
[Journal Article] Identification of three commonly deleted regions on chromosome arm 6q in human pancreatic cancer.1999
- Author(s)
  Abe, T., Makino, N., Furukawa, T, Ouyang, H., Kimura, M., Yatsuoka, T., Yokoyama, T., Inoue, H., Fukushige, S., Hoshi, M., Hayashi, Y., Sunamura, M., Kobari, M., Matsuno, S., Horii.A.
- Journal Title
  
  Genes Chromosomes Cancer 25
  
  Pages: 60-64
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10307032

1. SUNAMURA Makoto (10201584)

# of Collaborated Projects: 14 results

# of Collaborated Products: 13 results
2. TAKEDA Kazunori (20171639)

# of Collaborated Projects: 10 results

# of Collaborated Products: 3 results
3. KOBARI Masao (30170369)

# of Collaborated Projects: 6 results

# of Collaborated Products: 5 results
4. SIBUYA Kazuhiko (70260429)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
5. EGAWA Shin-ichi (00270679)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
6. SASAKI Iwao (60125557)

# of Collaborated Projects: 4 results

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7. NAITO Hiroo (90180223)

# of Collaborated Projects: 4 results

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8. FUKUSHIMA Kouhei (20271900)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. FUNAYAMA Yuji (50192315)

# of Collaborated Projects: 3 results

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10. SASAZUKI Tekehiko (50014121)

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11. SHOJI Testuo (80091700)

# of Collaborated Projects: 3 results

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12. FUKUYAMA Shoji (10344673)

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13. SHIIBA Ken-ichi (90196345)

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14. YOKOTA Jun (10191503)

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15. SHIBATA Chikashi (30270804)

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22. 島村弘宗 (70312585)

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23. WATANABE Yutaka (10260415)

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24. HORII Akira (40249983)

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25. FUKUSHIGE Shinichi (90192723)

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26. SEKI Naoko (40226634)

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27. MIZOI Takayuki (90271949)

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28. SHICHIJO Shigeki (30080592)

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29. ARIMURA Yoshiaki (80305218)

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30. NAISHIRO Yasuyoshi (80347161)

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31. INOKO Hidetoshi (10101932)

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32. YAMAMOTO Ken (60274528)

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33. KATAYOSE Yu (20302151)

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34. ABE Takaaki (80292209)

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35. UNNO Michiaki (70282043)

# of Collaborated Projects: 1 results

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36. MARUYAMA Ikuro (20082282)

# of Collaborated Projects: 1 results

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37. MIYAZAKI Jyunichi (10200156)

# of Collaborated Projects: 1 results

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38. 時野隆至 (40202197)

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39. 田中雅夫 (30163570)

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40. 高後裕 (10133183)

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41. 税所宏光 (10092058)

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42. 乾和郎 (20247638)

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43. 元井冬彦 (30343057)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
44. 角川陽一郎 (60221173)

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45. 高橋道長 (60206852)

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46. 中島美樹子 (80005488)

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47. 佐々木泰史 (70322328)

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48. 源利成 (50239323)

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49. 鈴木正徳 (70206530)

# of Collaborated Projects: 1 results

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50. 宮川菊雄 (10124629)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
51. 久野弘武 (30181093)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
52. 宮下英士 (00133059)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
53. 赤石敏 (70202504)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
54. 中村隆司 (40201678)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
55. KAQUNORI Takeda

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
56. 福山尚冶

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

MATUNO Seiki 松野 正紀

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多機能ウイルス遺伝子EIAを用いた転写因子制御の膵癌転移抑制療法Principal Investigator

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Tissue Engineering技術を応用したブタ新生児膵ラ島の分化誘導Principal Investigator

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New Frontiers of Bile Acid Research -Act as a Transcriptional factor for Liver and Gastrointestinal cancers-Principal Investigator

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インピーダンススペクトロスコピー法を用いた全く新しい消化管運動機能測定法の開発Principal Investigator

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Development of system to measure GI motility and morphology utilizing improved magnetic fluid.Principal Investigator

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Establishment of novel efficient methods for pancreatic cancer patients based on genetic abnormality.Principal Investigator

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MATUNO Seiki 松野正紀

[Journal Article] 膵癌膵癌の早期診断の進め方2004